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生成式AI大模型的风险问题与规制进路:以GPT-4为例 被引量:8
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作者 王晓丽 严驰 《北京航空航天大学学报(社会科学版)》 2025年第2期17-27,共11页
生成式人工智能的发展为人类社会带来了深层次和颠覆性的挑战。GPT-4在技术更新的同时也引发了底层算法、训练数据、知识产权方面的风险。在底层算法上,尽管GPT-4中潜藏着算法歧视的风险,但算法公开殊无必要,应借鉴类脑研究思路,推动GP... 生成式人工智能的发展为人类社会带来了深层次和颠覆性的挑战。GPT-4在技术更新的同时也引发了底层算法、训练数据、知识产权方面的风险。在底层算法上,尽管GPT-4中潜藏着算法歧视的风险,但算法公开殊无必要,应借鉴类脑研究思路,推动GPT-4走向通用人工智能;在训练数据上,GPT-4背后的海量数据存在较大的合规风险,应设立数据销毁制度,维护意识形态安全,探索中国特色发展方案;在知识产权上,GPT-4带来了一系列侵权风险,引发了生成物的作品属性认定争议,但尚无法构成对人类的作者主体资格的挑战。为更好地应对生成式人工智能大模型技术发展风险,应及时制定合适的规制方案,在元规制理论下,借鉴欧盟《数字服务法》中的制度设计,结合已有算法治理实践,寻求数字时代的自主创新,助力人工智能产业安全发展。 展开更多
关键词 人工智能 GPT-4 大模型 算法歧视 数据安全 知识产权
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基于BlendMask与改进Super4PCS的物体位姿估计方法
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作者 郑银环 张帅彬 +1 位作者 吴飞 陈恩杰 《合肥工业大学学报(自然科学版)》 北大核心 2025年第1期10-18,58,共10页
针对工业上常见的散乱堆叠工件的位姿估计和无序分拣问题,文章提出一种基于BlendMask实例分割算法与改进Super 4PCS(super 4-points congruent sets)点云配准算法的物体位姿估计方法。利用BlendMask实例分割算法分割目标工件并构建工件... 针对工业上常见的散乱堆叠工件的位姿估计和无序分拣问题,文章提出一种基于BlendMask实例分割算法与改进Super 4PCS(super 4-points congruent sets)点云配准算法的物体位姿估计方法。利用BlendMask实例分割算法分割目标工件并构建工件表面点云;定义抓取分数选择最上层工件作为抓取对象,实现机器人自上而下抓取;针对不同形状的目标工件,基于相似匹配度函数选择模板点云;融合Super 4PCS与正态分布转换(normal distributions transform,NDT)算法完成目标点云和模板点云在低重合率情况下的精确配准,获取目标工件的抓取位姿;并针对Super 4PCS算法粗配准时速度较慢的问题,通过对体素滤波后的目标点云和模板点云提取3D内部形状描述子(intrinsic shape signatures,ISS)作为点云配准算法的输入点集来提高算法的配准速度。点云配准实验和机器人无序分拣实验结果表明,文章提出的物体位姿估计方法可以快速、准确地完成目标工件的位姿估计和无序分拣任务,配准算法均方根误差(root mean square error,RMSE)小于3.8 mm,位姿估计所需时间小于5.8 s,性能满足实际应用要求。 展开更多
关键词 散乱堆叠工件 位姿估计 无序分拣 BlendMask实例分割算法 Super 4PCS算法 点云配准
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血清CA125和HE4及ROMA指数在宫颈癌及其癌前病变诊断中的意义
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作者 罗玲 蔡梦珊 +2 位作者 禤雪靖 林向华 王晓晨 《社区医学杂志》 2025年第12期416-421,432,共7页
目的 分析血清糖类抗原125(CA125)、人附睾蛋白4(HE4)和卵巢癌风险预测模型(ROMA)指数在宫颈癌及其癌前病变宫颈上皮内瘤变(CIN)诊断中的临床价值。方法 选取2022-06-01-2023-01-31中山大学孙逸仙纪念医院就诊的宫颈癌患者(绝经前45例... 目的 分析血清糖类抗原125(CA125)、人附睾蛋白4(HE4)和卵巢癌风险预测模型(ROMA)指数在宫颈癌及其癌前病变宫颈上皮内瘤变(CIN)诊断中的临床价值。方法 选取2022-06-01-2023-01-31中山大学孙逸仙纪念医院就诊的宫颈癌患者(绝经前45例和绝经后41例)和CIN患者(绝经前46例和绝经后22例),选取同期健康体检者(绝经前45名和绝经后40名)为健康对照。使用电化学发光法检测健康对照和患者进行治疗前的血清CA125和HE4水平,ROMA指数根据公式计算。分别分析绝经前后宫颈癌患者、CIN患者和健康对照的血清CA125、HE4和ROMA指数水平,使用受试者工作特征(ROC)曲线和曲线下面积(AUC)评价血清CA125、HE4和ROMA指数对绝经前和绝经后宫颈癌和CIN的诊断效能。结果 绝经前宫颈癌患者、CIN患者和健康对照血清CA125水平分别为24.000(13.800,44.100) U/mL、15.150(10.280,21.980) U/mL和13.700(9.900,16.900) U/mL,HE4水平分别为49.800(42.200,80.550) pmol/L、42.900(38.250,49.700) pmol/L和43.700(40.950,47.900) pmol/L,ROMA指数水平分别为7.800(5.250,21.200)%、5.300(3.975,7.500)%和5.600(4.750,6.700)%。绝经前宫颈癌患者血清CA125、HE4和ROMA指数均显著高于CIN患者和健康对照,宫颈癌患者与CIN患者相比,U值分别为659.000、599.000和583.500,P值分别为0.003、<0.001和<0.001;宫颈癌患者与健康对照相比,U值分别为514.500、648.000和610.000,P值分别为<0.001、0.003和0.001,但血清CA125、HE4和ROMA指数在绝经前CIN患者和健康对照间差异无统计学意义,U值分别为832.500、925.000和933.500,P值分别为0.109,0.385和0.423。绝经后宫颈癌患者、CIN患者和健康对照血清CA125水平分别为14.400(9.100,25.050) U/mL、13.050(9.425,15.630) U/mL和8.480(7.440,10.280) U/mL,HE4水平分别为62.400(46.400,101.900) pmol/L、52.600(44.800,60.680) pmol/L和54.700(48.200,61.980) pmol/L,ROMA指数水平分别为14.600(8.700,24.750)%、10.850(8.025,13.000)%和8.850(7.500,10.200)%。绝经后的宫颈癌和CIN患者血清CA125水平均显著高于健康对照,U值分别为384.500和178.500,均P<0.001,但宫颈癌和CIN患者之间血清CA125水平差异无统计学意义,U=385.000,P=0.346;ROMA指数水平在绝经后健康对照、CIN患者和宫颈癌患者中依次显著升高,宫颈癌患者与健康对照相比,差异有统计学意义,U=379.000,P<0.001,CIN患者与健康对照相比,差异有统计学意义,U=267.000,P=0.010,宫颈癌患者与CIN患者相比,差异有统计学意义,U=302.500,P=0.032;血清HE4水平在绝经后健康对照、CIN患者和宫颈癌患者间差异无统计学意义,H=5.290,P=0.071。血清CA125、HE4和ROMA指数诊断绝经前宫颈癌的诊断效能AUC分别为0.713(95%CI为0.611~0.816)、0.696(95%CI为0.595~0.796)和0.709(95%CI为0.610~0.808);血清CA125诊断绝经后宫颈癌和CIN(不区分)的AUC为0.777(95%CI为0.688~0.865),ROMA指数区别绝经后CIN和健康对照的AUC为0.697(95%CI为0.553~0.841),ROMA指数区别绝经后宫颈癌和CIN的AUC为0.665(95%CI为0.529~0.801)。结论 血清CA125、HE4和ROMA指数对宫颈癌及其癌前病变的辅助诊断有一定的临床意义,但是在使用中需要对绝经前后的患者进行区分,分别进行结果的判断和解读。 展开更多
关键词 糖类抗原125 人附睾蛋白4 卵巢癌风险预测模型 宫颈癌 宫颈上皮内瘤变
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Research on Different Heuristics for Minimax Algorithm Insight from Connect-4 Game 被引量:2
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作者 Xiyu Kang Yiqi Wang Yanrui Hu 《Journal of Intelligent Learning Systems and Applications》 2019年第2期15-31,共17页
Minimax algorithm and machine learning technologies have been studied for decades to reach an ideal optimization in game areas such as chess and backgammon. In these fields, several generations try to optimize the cod... Minimax algorithm and machine learning technologies have been studied for decades to reach an ideal optimization in game areas such as chess and backgammon. In these fields, several generations try to optimize the code for pruning and effectiveness of evaluation function. Thus, there are well-armed algorithms to deal with various sophisticated situations in gaming occasion. However, as a traditional zero-sum game, Connect-4 receives less attention compared with the other members of its zero-sum family using traditional minimax algorithm. In recent years, new generation of heuristics is created to address this problem based on research conclusions, expertise and gaming experiences. However, this paper mainly introduced a self-developed heuristics supported by well-demonstrated result from researches and our own experiences which fighting against the available version of Connect-4 system online. While most previous works focused on winning algorithms and knowledge based approaches, we complement these works with analysis of heuristics. We have conducted three experiments on the relationship among functionality, depth of searching and number of features and doing contrastive test with sample online. Different from the sample based on summarized experience and generalized features, our heuristics have a basic concentration on detailed connection between pieces on board. By analysing the winning percentages when our version fights against the online sample with different searching depths, we find that our heuristics with minimax algorithm is perfect on the early stages of the zero-sum game playing. Because some nodes in the game tree have no influence on the final decision of minimax algorithm, we use alpha-beta pruning to decrease the number of meaningless node which greatly increases the minimax efficiency. During the contrastive experiment with the online sample, this paper also verifies basic characters of the minimax algorithm including depths and quantity of features. According to the experiment, these two characters can both effect the decision for each step and none of them can be absolutely in charge. Besides, we also explore some potential future issues in Connect-4 game optimization such as precise adjustment on heuristic values and inefficiency pruning on the search tree. 展开更多
关键词 HEURISTICS MINIMAX algorithm ZERO-SUM GAME Connect-4 GAME
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A multi-objective multi-memetic algorithm for network-wide conflict-free 4D flight trajectories planning 被引量:9
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作者 Su YAN Kaiquan CAI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2017年第3期1161-1173,共13页
Under the demand of strategic air traffic flow management and the concept of trajectory based operations(TBO),the network-wide 4D flight trajectories planning(N4DFTP) problem has been investigated with the purpose... Under the demand of strategic air traffic flow management and the concept of trajectory based operations(TBO),the network-wide 4D flight trajectories planning(N4DFTP) problem has been investigated with the purpose of safely and efficiently allocating 4D trajectories(4DTs)(3D position and time) for all the flights in the whole airway network.Considering that the introduction of large-scale 4DTs inevitably increases the problem complexity,an efficient model for strategiclevel conflict management is developed in this paper.Specifically,a bi-objective N4 DFTP problem that aims to minimize both potential conflicts and the trajectory cost is formulated.In consideration of the large-scale,high-complexity,and multi-objective characteristics of the N4DFTP problem,a multi-objective multi-memetic algorithm(MOMMA) that incorporates an evolutionary global search framework together with three problem-specific local search operators is implemented.It is capable of rapidly and effectively allocating 4DTs via rerouting,target time controlling,and flight level changing.Additionally,to balance the ability of exploitation and exploration of the algorithm,a special hybridization scheme is adopted for the integration of local and global search.Empirical studies using real air traffic data in China with different network complexities show that the proposed MOMMA is effective to solve the N4 DFTP problem.The solutions achieved are competitive for elaborate decision support under a TBO environment. 展开更多
关键词 Air traffic flow management 4D trajectory planning Multi-memetic algorithm Multi-objective optimization Network-wide strategic conflict management
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Geometrically Nonlinear Deformation Reconstruction Based on iQS4 Elements Using a Linearized Iterative iFEM Algorithm 被引量:1
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作者 Mengying Li Dawei Jia +2 位作者 He Huang Ziyan Wu Adnan Kefal 《Acta Mechanica Solida Sinica》 SCIE EI CSCD 2023年第1期166-180,共15页
Structural shape monitoring plays a vital role in the structural health monitoring systems.The inverse finite element method(iFEM)has been demonstrated to be a practical method of deformation reconstruction owing to i... Structural shape monitoring plays a vital role in the structural health monitoring systems.The inverse finite element method(iFEM)has been demonstrated to be a practical method of deformation reconstruction owing to its unique advantages.Current iFEM formulations have been applied to small deformation of structures based on the small-displacement assumption of linear theory.However,this assumption may be inapplicable to some structures with large displacements in practical applications.Therefore,geometric nonlinearity needs to be considered.In this study,to expand the practical utility of iFEM for large displacement monitoring,we propose a nonlinear iFEM algorithm based on a four-node inverse quadrilateral shell element iQS4.Taking the advantage of an iterative iFEM algorithm,a nonlinear response is linearized to compute the geometrically nonlinear deformation reconstruction,like the basic concept of nonlinear FE analysis.Several examples are solved to verify the proposed approach.It is demonstrated that large displacements can be accurately estimated even if the in-situ sensor data includes different levels of randomly generated noise.It is proven that the nonlinear iFEM algorithm provides a more accurate displacement response as compared to the linear iFEM methodology for structures undergoing large displacement.Hence,the proposed approach can be utilized as a viable tool to effectively characterize geometrically nonlinear deformations of structures in real-time applications. 展开更多
关键词 Deformation reconstruction iQS4 element Iterative algorithm Nonlinear iFEM Geometric nonlinearity
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N4SID and MOESP Algorithms to Highlight the Ill-conditioning into Subspace Identification 被引量:4
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作者 Slim Hachicha Maher Kharrat Abdessattar Chaari 《International Journal of Automation and computing》 EI CSCD 2014年第1期30-38,共9页
In this paper,an analysis for ill conditioning problem in subspace identifcation method is provided.The subspace identifcation technique presents a satisfactory robustness in the parameter estimation of process model ... In this paper,an analysis for ill conditioning problem in subspace identifcation method is provided.The subspace identifcation technique presents a satisfactory robustness in the parameter estimation of process model which performs control.As a frst step,the main geometric and mathematical tools used in subspace identifcation are briefly presented.In the second step,the problem of analyzing ill-conditioning matrices in the subspace identifcation method is considered.To illustrate this situation,a simulation study of an example is introduced to show the ill-conditioning in subspace identifcation.Algorithms numerical subspace state space system identifcation(N4SID)and multivariable output error state space model identifcation(MOESP)are considered to study,the parameters estimation while using the induction motor model,in simulation(Matlab environment).Finally,we show the inadequacy of the oblique projection and validate the efectiveness of the orthogonal projection approach which is needed in ill-conditioning;a real application dealing with induction motor parameters estimation has been experimented.The obtained results proved that the algorithm based on orthogonal projection MOESP,overcomes the situation of ill-conditioning in the Hankel s block,and thereby improving the estimation of parameters. 展开更多
关键词 Subspace identification ILL-CONDITIONING oblique projection orthogonal projection algorithms numerical subspace state space system identification (N4SID) multivariable output error state space model identification (MOESP) induction motor
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Performance Evaluation of Scheduling Algorithms for 4G (LTE) 被引量:2
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作者 Bamidele Moses Kuboye 《Communications and Network》 2018年第4期152-163,共12页
Long Term Evolution (LTE) is designed to revolutionize mobile broadband technology with key considerations of higher data rate, improved power efficiency, low latency and better quality of service. This work analyzes ... Long Term Evolution (LTE) is designed to revolutionize mobile broadband technology with key considerations of higher data rate, improved power efficiency, low latency and better quality of service. This work analyzes the impact of resource scheduling algorithms on the performance of LTE (4G) and WCDMA (3G) networks. In this paper, a full illustration of LTE system is given together with different scheduling algorithms. Thereafter, 3G WCDMA and 4G LTE networks were simulated using Simulink simulator embedded in MATLAB and performance evaluations were carried out. The performance metrics used for the evaluations are average system throughput, packet delay, latency and allocation of fairness using Round Robin, Best CQI and Proportional fair Packet Scheduling Algorithms. The results of the evaluations on both networks were analysed. The results showed that 4G LTE network performs better than 3G WCDMA network in all the three scheduling algorithms used. 展开更多
关键词 LONG TERM Evolution THIRD GENERATION (3G) FOURTH GENERATION (4G) Network algorithms Scheduling
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Evaluation of the Use of Minimax Search in Connect-4—How Does the Minimax Search Algorithm Perform in Connect-4 with Increasing Grid Sizes?
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作者 Abdoul Wahab Touré 《Applied Mathematics》 2023年第6期419-427,共9页
As computers have become faster at performing computations over the decades, algorithms to play games have also become more efficient. This research paper seeks to see how the performance of the Minimax search evolves... As computers have become faster at performing computations over the decades, algorithms to play games have also become more efficient. This research paper seeks to see how the performance of the Minimax search evolves on increasing Connect-4 grid sizes. The objective of this study is to evaluate the effectiveness of the Minimax search algorithm in making optimal moves under different circumstances and to understand how well the algorithm scales. To answer this question we tested and analyzed the algorithm several times on different grid sizes with a time limit to see its performance as the complexity increases, we also looked for the average search depth for each grid size. The obtained results show that despite larger grid sizes, the Minimax search algorithm stays relatively consistent in terms of performance. 展开更多
关键词 MINIMAX Alpha-Beta Pruning Connect-4 algorithms
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A Message Digest Disposing Algorithm Based on RC4
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作者 LIUYabin CHEN Jing DU Ruiying ZHANG Huanguo 《Wuhan University Journal of Natural Sciences》 CAS 2010年第3期251-254,共4页
The characteristics of the wireless network determine the requirement of lightweight cryptography. Towards the huge cost of an existing algorithm such as MD5, this paper proposes a message digest scheme based on the R... The characteristics of the wireless network determine the requirement of lightweight cryptography. Towards the huge cost of an existing algorithm such as MD5, this paper proposes a message digest scheme based on the RC4 algorithm which broadens the application area of the RC4 and decreases the requirement of resource or cost. To test the randomicity of the algorithm's di- gest, fifteen kinds of randomicity test to NIST randomicity test standard had been done, and the comparative analysis which compares the digest's randomicity of the algorithm with MD5 had been performed as well. The performance of the algorithm had been analyzed in aspects of mono-directivity, randomicity, practicality and complexness. Statistic tests and analysis results illustrated that our scheme was of low cost of computing, good statistic performance, high running speed and lightweight. 展开更多
关键词 RC4 message digest algorithm CRYPTOGRAPHY information security
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基于改进Radix-4 Booth算法的逻辑综合中有符号乘法器设计
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作者 王立华 张家胜 徐丽 《山东科技大学学报(自然科学版)》 北大核心 2025年第5期101-110,共10页
逻辑综合是集成电路设计的重要环节,在逻辑综合时乘法器单元需要自行设计。为优化有符号乘法器的电路延时并减小电路面积,提高乘法器的整体性能,本研究基于改进Radix-4 Booth算法设计了一种有符号乘法器。采用资源复用Booth编码器,将3... 逻辑综合是集成电路设计的重要环节,在逻辑综合时乘法器单元需要自行设计。为优化有符号乘法器的电路延时并减小电路面积,提高乘法器的整体性能,本研究基于改进Radix-4 Booth算法设计了一种有符号乘法器。采用资源复用Booth编码器,将3位编码转换为2个控制信号,共同控制Booth选择器生成部分积,部分积的符号位则使用简单的电路统一扩展;采用进位保留加法器阵列对重组后的部分积进行压缩求和,缩短关键路径,减少电路面积。基于SMIC 28 nm工艺库,对采用改进算法设计的16×16 bit有符号乘法器进行逻辑等价性检查与逻辑综合,逻辑综合后网表的电路延时、电路面积与资源信息表明,该方法能较好地提升乘法器的电路性能。 展开更多
关键词 有符号乘法器 Radix-4 Booth算法 部分积重组 逻辑综合
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上皮性卵巢癌患者血清IGF-1、B7-H4、miR-362水平与ROMA指数和预后的关系
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作者 马云芳 史昭 +1 位作者 张慧 刘永芳 《检验医学与临床》 2025年第18期2504-2509,共6页
目的探讨上皮性卵巢癌(EOC)患者血清胰岛素样生长因子1(IGF-1)、B7同源蛋白4(B7-H4)、微小核糖核酸-362(miR-362)水平与卵巢恶性肿瘤风险算法(ROMA)指数和预后的关系。方法选取2022年1月至2023年6月该院收治的140例EOC患者作为研究组,... 目的探讨上皮性卵巢癌(EOC)患者血清胰岛素样生长因子1(IGF-1)、B7同源蛋白4(B7-H4)、微小核糖核酸-362(miR-362)水平与卵巢恶性肿瘤风险算法(ROMA)指数和预后的关系。方法选取2022年1月至2023年6月该院收治的140例EOC患者作为研究组,另选取同期该院收治的卵巢良性肿瘤患者70例作为疾病对照组,以及同期该院体检健康女性70例作为健康对照组。比较3组血清IGF-1、B7-H4、miR-362水平及ROMA指数,分析EOC患者血清IGF-1、B7-H4、miR-362水平与ROMA指数的相关性,采用受试者工作特征(ROC)曲线分析血清IGF-1、B7-H4、miR-362诊断EOC的价值。分析EOC患者血清IGF-1、B7-H4、miR-362与临床病理特征的关系,并对比不同血清IGF-1、B7-H4、miR-362水平EOC患者的1年生存率。结果健康对照组血清IGF-1、B7-H4水平低于疾病对照组和研究组(P<0.05),且疾病对照组低于研究组(P<0.05),健康对照组miR-362水平高于疾病对照组和研究组(P<0.05),且疾病对照组高于研究组(P<0.05);研究组ROMA指数高于疾病对照组(P<0.05)。EOC患者血清IGF-1、B7-H4水平与ROMA指数呈正相关(P<0.05),miR-362水平与ROMA指数呈负相关(P<0.05)。血清IGF-1、B7-H4、miR-362诊断EOC的曲线下面积(AUC)分别为0.787、0.762、0.815,三者联合诊断EOC的AUC为0.927,大于各指标单独诊断的AUC(P<0.05)。血清IGF-1、B7-H4水平与EOC肿瘤最大径、国际妇产科联合会(FIGO)分期、淋巴结转移呈正相关(P<0.05),与分化程度呈负相关(P<0.05);miR-362水平与EOC肿瘤最大径、FIGO分期、淋巴结转移呈负相关(P<0.05),与分化程度呈正相关(P<0.05)。研究组随访1年,失访3例,1年生存率为80.29%(110/137)。血清IGF-1、B7-H4高表达患者1年生存率分别为74.44%(67/90)、75.26%(73/97),低于低表达患者的91.49%(43/47)、92.50%(37/40),miR-362低表达患者1年生存率为75.49%(77/102),低于高表达患者的94.29%(33/35),差异均有统计学意义(P<0.05)。结论EOC患者血清IGF-1、B7-H4、miR-362与ROMA指数具有相关性,3项指标对EOC均具有良好的诊断价值,且与临床病理特征密切相关,还对预后有一定影响。 展开更多
关键词 上皮性卵巢癌 胰岛素样生长因子1 B7同源蛋白4 微小核糖核酸-362 卵巢恶性肿瘤风险算法指数 预后
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边界网关协议BGP-4中路由信息的存储合并算法研究 被引量:3
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作者 徐恪 徐明伟 +1 位作者 王彬 吴建平 《计算机工程》 CAS CSCD 北大核心 2003年第2期55-56,77,共3页
针对BGP-4的AS路径和NEXT_HOP两个基本路由属性的特点逐步提出了一系列哈希算法,并采用真实的网络数据对其效果进行了检验。然后优选出一种算法分析了空间和时间性能。最后提出了路由的合并规则。
关键词 边界网关协议 BGP-4 路由信息 存储合并算法 INTERNET 路由器 哈希算法 AS路径 网络层可达信息
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优选优生进化算法及4-CBA软测量模型参数估计 被引量:5
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作者 颜学峰 余娟 钱锋 《高校化学工程学报》 EI CAS CSCD 北大核心 2005年第2期238-243,共6页
提出一种优选优生进化算法(select-best and prepotency evolution algorithm,SPEA),该算法中优选优生操作首先使群体中的所有个体都以相同的概率在自身所处环境的某个领域内选择最优个体进行交叉操作,不但保持后代个体的多样性,避免早... 提出一种优选优生进化算法(select-best and prepotency evolution algorithm,SPEA),该算法中优选优生操作首先使群体中的所有个体都以相同的概率在自身所处环境的某个领域内选择最优个体进行交叉操作,不但保持后代个体的多样性,避免早熟,而且使群体中较优个体多次参加交叉操作,保留优良信息,同时也避免了遗传算法(genetic algorithm,GA)中占用大量计算时间的种群挑选操作;然后挑选交叉操作产生的较优个体参与变异形成下一代个体,从而增强算法的局部搜索能力,使求得的全局最优解有较高的精度。与GA相比较,SPEA计算复杂性低,离线性能和在线性能都有较大的改进,局部搜索能力和全局寻优能力都有较大的提高。举例将SPEA应用于对苯二甲酸(terephthalic acid,TA)中对羧基苯甲醛(4-carboxybenzaldehyde,4-CBA)含量软测量模型的参数估计,获得了满意的结果。 展开更多
关键词 进化算法 遗传算法 对苯二甲酸 对羧基苯甲醛 参数估计
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HE4和CA125联合检测在上皮性卵巢癌风险评估中的应用 被引量:12
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作者 雷旦生 喻晶 +1 位作者 王堃 张顺 《华中科技大学学报(医学版)》 CAS CSCD 北大核心 2010年第6期853-855,共3页
目的探讨人附睾上皮分泌蛋白4(HE4)与CA125联合检测在卵巢癌风险评估中的应用价值。方法用ELISA法检测上皮性卵巢癌、妇科良性病变、其他妇科恶性肿瘤及其他系统恶性肿瘤共84例女性患者血清HE4和CA125水平,计算出卵巢恶性肿瘤风险值(ROM... 目的探讨人附睾上皮分泌蛋白4(HE4)与CA125联合检测在卵巢癌风险评估中的应用价值。方法用ELISA法检测上皮性卵巢癌、妇科良性病变、其他妇科恶性肿瘤及其他系统恶性肿瘤共84例女性患者血清HE4和CA125水平,计算出卵巢恶性肿瘤风险值(ROMA值),联合绝经状态评估患卵巢癌的风险性。结果由ROMA值结合绝经状态在84例患者中诊断出卵巢癌的敏感度和特异度分别为66.7%和91.7%,均高于单一CA125检测诊断出卵巢癌的敏感度(50.0%)和特异度(75.0%),差异有统计学意义(P<0.05)。结论根据HE4和CA125结果结合绝经状态计算卵巢恶性肿瘤风险值(ROMA值),在诊断卵巢癌的敏感度和特异度均高于单一CA125检测,有助于卵巢癌的诊断和疗效监测。 展开更多
关键词 人附睾上皮分泌蛋白4 卵巢恶性肿瘤风险值 卵巢癌
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基于BPANN的4-CBA软测量模型研究 被引量:5
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作者 胡永有 古勇 +2 位作者 苏宏业 王朝辉 褚健 《仪器仪表学报》 EI CAS CSCD 北大核心 2003年第3期226-230,240,共6页
本文提出了一个基于 3层 BP人工神经网络 (BPANN)新的 4 - CBA软测量模型。在 MATL AB软件平台上 ,利用两种改进 BP算法以及由正交试验和机理模型仿真所产生的大量数据样本对不同网络结构模型进行了学习训练和验证 ,并对算法的训练效果... 本文提出了一个基于 3层 BP人工神经网络 (BPANN)新的 4 - CBA软测量模型。在 MATL AB软件平台上 ,利用两种改进 BP算法以及由正交试验和机理模型仿真所产生的大量数据样本对不同网络结构模型进行了学习训练和验证 ,并对算法的训练效果进行了比较研究。仿真结果表明基于 L evenberg- Marquardt学习规则的合适结构 BPANN软测量模型 ,不仅学习快速 ,预测精度也远高于经验回归模型 ,为实现精对苯二甲酸 (PTA)产品中 4 - CBA含量的实时。 展开更多
关键词 精对苯二甲酸 PTA 4-CBA 软测量 BP神经网络 改进BP算法 回归模型
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血清HE4与CA125联合检测在盆腔包块患者恶性卵巢癌风险评估中的应用价值 被引量:8
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作者 潘莹莹 夏琳 +1 位作者 何小霞 程黎明 《国际检验医学杂志》 CAS 2013年第5期543-544,547,共3页
目的本研究应用血清人附睾蛋白4(HE4)与糖类蛋白125(CA125)联合检测并结合卵巢癌恶性风险模型(ROMA法则)对拟行手术的盆腔包块患者进行卵巢癌恶性风险评估,并探讨其应用价值。方法收集盆腔包块拟行手术患者196例血清(包括术前、术后),... 目的本研究应用血清人附睾蛋白4(HE4)与糖类蛋白125(CA125)联合检测并结合卵巢癌恶性风险模型(ROMA法则)对拟行手术的盆腔包块患者进行卵巢癌恶性风险评估,并探讨其应用价值。方法收集盆腔包块拟行手术患者196例血清(包括术前、术后),按术后病理诊断结果分为卵巢癌组和卵巢良性疾病组,并收集120例女性健康对照组血清,采用全自动化学发光微粒子免疫分析方法测定HE4和CA125水平并计算ROMA风险值。结果卵巢癌组血清HE4、CA125水平[分别为(227.46±375.68)pmol/L和(477.22±929.90)U/mL]与卵巢良性疾病组[(37.37±9.23)pmol/L和(51.04±61.06)U/mL]和健康对照组[分别为(35.75±9.71)pmol/L和(11.61±5.77)U/mL]比较,均呈显著升高(P<0.05);将75%的卵巢良性疾病分类为低风险所对应的ROMA值确定为判断标准,其中未绝经患者ROMA≥5.6%归为患上皮性卵巢癌的高风险性。而绝经患者RO-MA≥17.5%归为患上皮性卵巢癌的高风险性。按上述标准风险评估特异度75%,总的灵敏度为58.5%,阳性预测值为67.9%,阴性预测值为66.1%。结论联合检测盆腔包块患者血清HE4和CA125浓度并采用ROMA法则在评估患者恶性卵巢癌风险中具有一定的应用价值,为临床上卵巢癌的早发现、早诊治以及提高卵巢癌患者的预后水平提供了新的思路。 展开更多
关键词 卵巢肿瘤 CA125抗原 人附睾蛋白4 卵巢恶性肿瘤风险模型
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高性能基4快速傅里叶变换处理器的设计 被引量:11
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作者 段小东 顾立志 《计算机工程》 CAS CSCD 北大核心 2008年第24期238-240,243,共4页
研究并设计高性能基4快速傅里叶变换(FFT)处理器。采用基4算法、流水线结构的蝶形运算单元,提高了处理速度,使芯片能在更高的时钟频率上工作。运用溢出检测状态机对每个蝶形运算单元输出的数据进行块浮点检查,确保对溢出情况进行正确判... 研究并设计高性能基4快速傅里叶变换(FFT)处理器。采用基4算法、流水线结构的蝶形运算单元,提高了处理速度,使芯片能在更高的时钟频率上工作。运用溢出检测状态机对每个蝶形运算单元输出的数据进行块浮点检查,确保对溢出情况进行正确判断。验证与性能评估结果表明,该FFT处理器具有较高性能。 展开更多
关键词 快速傅里叶变换算法 4算法 块浮点算法 蝶形运算单元
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血清HE4与CA125联合检测在上皮性卵巢癌风险评估中的应用 被引量:13
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作者 谢则金 王厚照 +1 位作者 刘青 董佳 《临床军医杂志》 CAS 2012年第2期392-394,共3页
目的探讨血清人附睾上皮分泌蛋白4(HE4)与CA125联合检测在卵巢癌风险评估中的应用价值。方法采用CMIA法检测78例上皮性卵巢癌、41例妇科良性病变及50例健康对照者血清HE4和CA125水平。结果 (1)在未绝经组中,卵巢癌患者HE4与CA125水平明... 目的探讨血清人附睾上皮分泌蛋白4(HE4)与CA125联合检测在卵巢癌风险评估中的应用价值。方法采用CMIA法检测78例上皮性卵巢癌、41例妇科良性病变及50例健康对照者血清HE4和CA125水平。结果 (1)在未绝经组中,卵巢癌患者HE4与CA125水平明显高于卵巢良性疾病组和健康对照组(P<0.01)。(2)在绝经组中,卵巢癌患者HE4与CA125水平也明显高于卵巢良性疾病组和健康对照组(P<0.01)。(3)在未绝经组中,HE4单项检测对卵巢癌预测的特异度、阳性预测值(分别为95.7%和90.9%)高于CA125单项检测的特异度、阳性预测值(分别为69.9%和60.0%)。(4)在绝经组中,HE4单项检测对卵巢癌预测的特异度、阳性预测值(分别为92.7%和92.1%)也高于CA125单项检测的特异度、阳性预测值(分别为66.0%和69.2%)。(5)对于卵巢疾病患者,未绝经者与绝经者卵巢发病风险计算>7.4%和25.3%时,可能存在卵巢癌发病的高风险。结论 HE4是一种较理想的卵巢癌肿瘤标志物,HE4与CA125敏感性相当,但HE4单项检测诊断卵巢恶性肿瘤的特异性优于CA125单项检测,联合CA125检测对评估患卵巢癌的风险性有重要价值。 展开更多
关键词 人附睾上皮分泌蛋白4 卵巢恶性肿瘤风险值 卵巢癌
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血清人附睾分泌蛋白4和卵巢恶性肿瘤风险值在上皮性卵巢癌的诊断和风险评估中的应用价值 被引量:13
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作者 董作亮 杜雪 李江 《中国慢性病预防与控制》 CAS 2013年第4期440-442,共3页
目的探讨人附睾分泌蛋白4(HE4)及卵巢恶性肿瘤风险(ROMA)值在中国人群上皮性卵巢癌的诊断和卵巢癌风险评估中的应用价值。方法应用酶联免疫吸附试验(ELISA)法检测206例上皮性卵巢癌、子宫良性疾病,子宫内膜癌,卵巢良性疾病患者血清中HE... 目的探讨人附睾分泌蛋白4(HE4)及卵巢恶性肿瘤风险(ROMA)值在中国人群上皮性卵巢癌的诊断和卵巢癌风险评估中的应用价值。方法应用酶联免疫吸附试验(ELISA)法检测206例上皮性卵巢癌、子宫良性疾病,子宫内膜癌,卵巢良性疾病患者血清中HE4水平,选64例卵巢癌患者为恶性肿瘤组,57例良性卵巢肿瘤患者及60例健康者为对照组。经测定血清糖类抗原125(CA125)水平后,带入公式计算其ROMA值,结合绝经状态评价诊断和患卵巢癌的风险性。结果上皮性卵巢癌组患者HE4水平明显高于对照组、子宫良性疾病组、子宫内膜癌组及卵巢良性疾病组的患者,差异均有统计学意义(P<0.05)。经受试者工作特性曲线(ROC)分析,HE4的ROC曲线下面积为0.827,以150pmol/L为界值时,检测卵巢癌的灵敏度和特异度达73.4%和89.5%。由ROMA值结合绝经状态在121例患者中诊断出卵巢癌的敏感度和特异度分别为87.5%和77.2%,未绝经患者高危组罹患卵巢癌的风险是低危组的9.6倍;绝经患者高危组罹患卵巢癌的风险是低危组的3.8倍,绝经前后高风险间差异有统计学意义(P<0.01)。阳性预测值和阴性预测值分别为81.2%和88.0%。结论 HE4可作为临床诊断上皮性卵巢癌新的肿瘤标志物,ROMA值的计算有望成为评估患者上皮性卵巢癌风险的一种新的辅助手段。 展开更多
关键词 人附睾上皮分泌蛋白4 糖类抗原125 诊断试验 评价 卵巢恶性肿瘤风险值
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