The feasibility of applying optical coherence tomography （OCT） in determining the degree of myocardial ischemia-reperfusion injury is assessed. The left anterior descending coronary artery of 90 Sprague-Dawley rats ...The feasibility of applying optical coherence tomography （OCT） in determining the degree of myocardial ischemia-reperfusion injury is assessed. The left anterior descending coronary artery of 90 Sprague-Dawley rats are ligated and reperfused at different times. The total attenuation coefficient obtained from the OCT images in the experimental group keeps increasing with reperfusion time and highly correlates with the histopathological characteristics （P 〈 0.01）. We present evidence proving the feasibility of using OCT for evaluating myocardial ischemia reperfusion.展开更多
In order to find evidence of consistent sequence conservation or the base correlation degree in miRNA,some important sites in the sequences of reported miRNA and their precursors(pre-miRNA)were investigated via inform...In order to find evidence of consistent sequence conservation or the base correlation degree in miRNA,some important sites in the sequences of reported miRNA and their precursors(pre-miRNA)were investigated via information entropy analysis.Twelve different groups of sites were obtained from special locations(head,tail)in miRNAs of different sources according to taxonomy(animal,plant and virus)and then analyzed by measuring the single base information redundancy(D1(L))and the adjacent base related information redundancy(D2(L)).The results showed that D2(L)has more information than D1(L),though D1(L)changes roughly consistently with D2(L)in each group.Viral pre-miRNAs are more conservative than those belonging to animals or plants.In addition,U is dominant in most sites compared with other nucleotides.It was also found that in the middle of several groups,there were sites where miRNAs were cut down from pre-miRNAs by Enzyme Dicer which were significantly conservative.This phenomenon shows that the conservatism is an aspect of the of miRNA and may be involved in the recognition and cutting by the Dicer.Those results provided another perspective for understanding more about the primary structure of pre-miRNA.展开更多
基金supported by the Medical Innovation Topics of Health Department of Fujian Province under Grant No.2009-CX-1
文摘The feasibility of applying optical coherence tomography （OCT） in determining the degree of myocardial ischemia-reperfusion injury is assessed. The left anterior descending coronary artery of 90 Sprague-Dawley rats are ligated and reperfused at different times. The total attenuation coefficient obtained from the OCT images in the experimental group keeps increasing with reperfusion time and highly correlates with the histopathological characteristics （P 〈 0.01）. We present evidence proving the feasibility of using OCT for evaluating myocardial ischemia reperfusion.
基金Supported by the National Natural Science Foundation of China(Grant No.30600384)the Young Outstanding Scholar Foundation of Northwest Science and Technolgy University
文摘In order to find evidence of consistent sequence conservation or the base correlation degree in miRNA,some important sites in the sequences of reported miRNA and their precursors(pre-miRNA)were investigated via information entropy analysis.Twelve different groups of sites were obtained from special locations(head,tail)in miRNAs of different sources according to taxonomy(animal,plant and virus)and then analyzed by measuring the single base information redundancy(D1(L))and the adjacent base related information redundancy(D2(L)).The results showed that D2(L)has more information than D1(L),though D1(L)changes roughly consistently with D2(L)in each group.Viral pre-miRNAs are more conservative than those belonging to animals or plants.In addition,U is dominant in most sites compared with other nucleotides.It was also found that in the middle of several groups,there were sites where miRNAs were cut down from pre-miRNAs by Enzyme Dicer which were significantly conservative.This phenomenon shows that the conservatism is an aspect of the of miRNA and may be involved in the recognition and cutting by the Dicer.Those results provided another perspective for understanding more about the primary structure of pre-miRNA.
