In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This...In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.展开更多
A comprehensive evaluation index system is constructed,and the entropy weight TOPSIS method isused to measure the optimization level of the digital economy and tourism industry structure of 30 provinces inChina from 2...A comprehensive evaluation index system is constructed,and the entropy weight TOPSIS method isused to measure the optimization level of the digital economy and tourism industry structure of 30 provinces inChina from 2012 to 2021.Moreover,models such as quantile regression and panel threshold are used to explorethe influence of the digital economy(DIG)on the optimization of the tourism industry structure(TIS)as well as itstransmission mechanism.The study reveals that DIG significantly promotes TIS,which remains valid after endogeneity and robustness tests;the impact of DIG on TIS exhibited a“U-shape”effect that first decreases and thenincreases,and its highest significance is at the 90%quartile level.Threshold model tests revealed a nonlinearthreshold effect with DIG and tourism total factor productivity(TTFP)as a single threshold and tourism technological progress index(TECH)as a double threshold,and the second threshold has the largest effect of 0.163.Mechanism analysis found that the mediating impact of the DIG on the TIS was mediated by increasing the TTFP,and the TECH accounted for the highest proportion of 12.15%.Regional analysis revealed that the role of DIG onthe TIS is Central>East>West>Northeast,and the empowering effect is more significant in the high digital economylevel area and the high tourism industry structure optimization area.展开更多
在文献中,分位点回归模型是线性的,但是在实际中,这个假设不能很好地满足需要.为此提出了分位点回归的门限模型,用该模型实证分析了单只股票(浦东发展银行)的条件 VaR.选择了一种流动性风险指标作为条件,因此该条件 VaR 也可以看作是流...在文献中,分位点回归模型是线性的,但是在实际中,这个假设不能很好地满足需要.为此提出了分位点回归的门限模型,用该模型实证分析了单只股票(浦东发展银行)的条件 VaR.选择了一种流动性风险指标作为条件,因此该条件 VaR 也可以看作是流动性调整的 VaR(La-VaR).经过实证分析发现,由门限分位点模型得到的结果能够更好地描述实际市场情况,也能更好地预测市场风险.展开更多
知情交易概率(probability of informed trading,PIN)是市场微观结构中度量知情交易的一种重要度量方法.给出了一种基于交易量的PIN估计方法VPIN(volume-synchronized probability of informed trading).并应用门限分位点回归模型分析了...知情交易概率(probability of informed trading,PIN)是市场微观结构中度量知情交易的一种重要度量方法.给出了一种基于交易量的PIN估计方法VPIN(volume-synchronized probability of informed trading).并应用门限分位点回归模型分析了VPIN与收益率之间的非线性结构关系,给出了VPIN条件下市场风险(conditional value at risk,CVaR)的度量方法.最后对上证综指数据进行了实证分析,实证结果表明VPIN和日收益率之间存在着较为显著的关系,VPIN越大,相应的市场风险CVaR越小.展开更多
The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carb...The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect model.It is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western region.Under different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.展开更多
基金Supported by the Natural Science Foundation of Fujian Province(2022J011177,2024J01903)the Key Project of Fujian Provincial Education Department(JZ230054)。
文摘In clinical research,subgroup analysis can help identify patient groups that respond better or worse to specific treatments,improve therapeutic effect and safety,and is of great significance in precision medicine.This article considers subgroup analysis methods for longitudinal data containing multiple covariates and biomarkers.We divide subgroups based on whether a linear combination of these biomarkers exceeds a predetermined threshold,and assess the heterogeneity of treatment effects across subgroups using the interaction between subgroups and exposure variables.Quantile regression is used to better characterize the global distribution of the response variable and sparsity penalties are imposed to achieve variable selection of covariates and biomarkers.The effectiveness of our proposed methodology for both variable selection and parameter estimation is verified through random simulations.Finally,we demonstrate the application of this method by analyzing data from the PA.3 trial,further illustrating the practicality of the method proposed in this paper.
基金The National Natural Science Foundation of China(42261042)The Hunan Provincial Natural Science Foundation(2024JJ7410)The Hunan Provincial Graduate Student Research and Innovation Program(CX20221095)。
文摘A comprehensive evaluation index system is constructed,and the entropy weight TOPSIS method isused to measure the optimization level of the digital economy and tourism industry structure of 30 provinces inChina from 2012 to 2021.Moreover,models such as quantile regression and panel threshold are used to explorethe influence of the digital economy(DIG)on the optimization of the tourism industry structure(TIS)as well as itstransmission mechanism.The study reveals that DIG significantly promotes TIS,which remains valid after endogeneity and robustness tests;the impact of DIG on TIS exhibited a“U-shape”effect that first decreases and thenincreases,and its highest significance is at the 90%quartile level.Threshold model tests revealed a nonlinearthreshold effect with DIG and tourism total factor productivity(TTFP)as a single threshold and tourism technological progress index(TECH)as a double threshold,and the second threshold has the largest effect of 0.163.Mechanism analysis found that the mediating impact of the DIG on the TIS was mediated by increasing the TTFP,and the TECH accounted for the highest proportion of 12.15%.Regional analysis revealed that the role of DIG onthe TIS is Central>East>West>Northeast,and the empowering effect is more significant in the high digital economylevel area and the high tourism industry structure optimization area.
文摘在文献中,分位点回归模型是线性的,但是在实际中,这个假设不能很好地满足需要.为此提出了分位点回归的门限模型,用该模型实证分析了单只股票(浦东发展银行)的条件 VaR.选择了一种流动性风险指标作为条件,因此该条件 VaR 也可以看作是流动性调整的 VaR(La-VaR).经过实证分析发现,由门限分位点模型得到的结果能够更好地描述实际市场情况,也能更好地预测市场风险.
文摘知情交易概率(probability of informed trading,PIN)是市场微观结构中度量知情交易的一种重要度量方法.给出了一种基于交易量的PIN估计方法VPIN(volume-synchronized probability of informed trading).并应用门限分位点回归模型分析了VPIN与收益率之间的非线性结构关系,给出了VPIN条件下市场风险(conditional value at risk,CVaR)的度量方法.最后对上证综指数据进行了实证分析,实证结果表明VPIN和日收益率之间存在着较为显著的关系,VPIN越大,相应的市场风险CVaR越小.
基金supported by the Fund of Fujian Provincial Xi Jinping Thought on Socialism with Chinese Characteristics for a New Era(Grant No.FJ2023XZB057)Major Project Fund of Fujian Provincial Social Science Research Base(Grant No.FJ2023JDZ021).
文摘The digital economy,as a new emerging economic form,has become an important power for realizing Chinese-style modernization and promoting green development in China.This paper measures the digital economy and low-carbon transition index based on the data of 30 provinces in China from 2013 to 2020 and analyzes the mechanism and path of the digital economy affecting low-carbon transition using the fixed effect panel data model and the threshold effect model.It is found that,(1)The digital economy and low-carbon transition in China are various in different regions,with characteristics of being unbalanced and insufficient.(2)The digital economy significantly promotes low-carbon transition,with the greatest influence in the Central region,followed by the Eastern region and the Western region.Under different dimensions,the development of informatization and digital transactions promote low-carbon transition,but the development of the internet plays an inhibiting role.(3)The higher the degree of urbanization and environmental regulation,the greater the influence of the digital economy on low-carbon transition.
