Purpose-This paper provides a comprehensive analysis of the Brazilian freight railway system,examining the efficacy of the current concession renewal model in light of persistent structural problems such as market con...Purpose-This paper provides a comprehensive analysis of the Brazilian freight railway system,examining the efficacy of the current concession renewal model in light of persistent structural problems such as market concentration,cargo dependence on export commodities and underutilization of the network.Situating Brazil within the broader international debate on railway reforms,the paper evaluates whether the ongoing early renewal of concessions can deliver a more diversified and competitive freight system.Design/methodology/approach-The study adopts a sequential mixed-methods research design that integrates longitudinal quantitative analysis with qualitative institutional and policy evaluation.The quantitative component examines time-series indicators published by ANTT,DNIT and INFRA S.A.from 1999 to 2023 to identify structural patterns in traffic growth,investment,safety and market concentration.The qualitative component employs a process-tracing logic to reconstruct the evolution of concession renewals and the implementation of Railway Law 14.273/2021,drawing on concepts from regulatory economics,institutional theory and industrial organization.These empirical streams are synthesized through an analytical framework that connects three dimensions-regulatory design,market structure and system performance-allowing for a systematic assessment of how Brazil’s institutional configuration shapes incentives,competitive dynamics and network utilization.Findings-The analysis confirms that the early renewal of concessions has successfully secured substantial private investment for capacity expansion on existing trunk lines.However,it has perpetuated the vertically integrated model,reinforcing the market power of incumbent operators and failing to significantly promote intramodal competition or cargo diversification.The system remains dominated by iron ore and agricultural commodities,with general cargo representing a minuscule share.The new authorization regime and short-line railway policies present a viable pathway for market opening but face significant operational and institutional barriers to implementation.Originality/value-This research offers a timely and critical assessment of a pivotal moment in Brazilian railway policy.It moves beyond a simplistic evaluation of volume growth to a structural analysis of market failures and the interplay between concession renewal and regulatory innovation.The findings provide actionable insights for policymakers in Brazil and other emerging economies seeking to balance private investment with public interest goals in railway infrastructure,highlighting the necessity of complementary,pro-competitive measures alongside financial investment.展开更多
These days,data is regarded as a valuable asset in the era of the data economy,which demands a trading platform for buying and selling data.However,online data trading poses challenges in terms of security and fairnes...These days,data is regarded as a valuable asset in the era of the data economy,which demands a trading platform for buying and selling data.However,online data trading poses challenges in terms of security and fairness because the seller and the buyer may not fully trust each other.Therefore,in this paper,a blockchain-based secure and fair data trading system is proposed by taking advantage of the smart contract and matchmaking encryption.The proposed system enables bilateral authorization,where data trading between a seller and a buyer is accomplished only if their policies,required by each other,are satisfied simultaneously.This can be achieved by exploiting the security features of the matchmaking encryption.To guarantee non-repudiation and fairness between trading parties,the proposed system leverages a smart contract to ensure that the parties honestly carry out the data trading protocol.However,the smart contract in the proposed system does not include complex cryptographic operations for the efficiency of onchain processes.Instead,these operations are carried out by off-chain parties and their results are used as input for the on-chain procedure.The system also uses an arbitration protocol to resolve disputes based on the trading proof recorded on the blockchain.The performance of the protocol is evaluated in terms of off-chain computation overhead and on-chain gas consumption.The results of the experiments demonstrate that the proposed protocols can enable the implementation of a cost-effective data trading system.展开更多
The specification of authorization policies in access control models proposed so far cannot satisfy the requirements in workflow management systems(WFMSs).Furthermore,existing approaches have not provided effective co...The specification of authorization policies in access control models proposed so far cannot satisfy the requirements in workflow management systems(WFMSs).Furthermore,existing approaches have not provided effective conflict detection and resolution methods to maintain the consistency of authorization polices in WFMSs.To address these concerns,we propose the definition of authorization policies in which context constraints are considered and the complicated requirements in WFMSs can be satisfied.Based on the definition,we put forward static and dynamic conflict detection methods for authorization policies.By defining two new concepts,the precedence establishment rule and the conflict resolution policy,we provide a flexible approach to resolving conflicts.展开更多
User-centric data sharing is essential to encourage citizens'active participation in the digital economy.One key to smart cities,a form of the digital economy,is the promotion of public use of citizen data.Neverth...User-centric data sharing is essential to encourage citizens'active participation in the digital economy.One key to smart cities,a form of the digital economy,is the promotion of public use of citizen data.Nevertheless,it is not easy to utilize data without citizens’consent.In this study,we took a technological approach to these issues.Usermanaged access(UMA)is a well-known framework for delegating resource access rights to others on the Internet.In UMA,authorization mechanisms are designed to be centralized so that resource owners can centrally manage access rights for various resources stored in different domains.However,the lack of transparency in the authorization mechanism is a barrier to its implementation in large-scale systems such as smart cities.In this study,we developed a blockchain-based cross-domain authorization architecture that enables a resource-sharing ecosystem in which organizations that wish to utilize data can freely trade with each other.The proposed architecture solves the transparency problem that conventional authorization systems have had by designing the authorization mechanism on blockchain technology.We implemented the proposed architecture as smart contracts and evaluated its processing performance.The resultant time required for delegating access rights and accessing resources was less than 500 ms.Furthermore,we found that the fluctuation in the processing time overhead was small.Based on these results,we concluded that performance degradation with the proposed architecture is minor.展开更多
Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the m...Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.展开更多
Should the article be accepted and published by Meteorological and Environmental Research , the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital rep...Should the article be accepted and published by Meteorological and Environmental Research , the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction, distribution, compilation and information network transmission rights.展开更多
Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital repro...Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.展开更多
Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,dist...Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,distribution,compilation and information network transmission rights.展开更多
Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital repro...Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.展开更多
Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital repro...Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.展开更多
Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,dist...Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,distribution,compilation and information network transmission rights.展开更多
Objective To ensure the quality and safety of drugs in the whole cycle of pharmaceutical commissioned production under the drug marketing authorization holder(MAH)system,and to establish a perfect quality management s...Objective To ensure the quality and safety of drugs in the whole cycle of pharmaceutical commissioned production under the drug marketing authorization holder(MAH)system,and to establish a perfect quality management system for it.Methods Literature review was used to study the factors that influenced the quality management system of pharmaceutical commissioned production because the implementation of MAH system in China was late,and the experience accumulated by pharmaceutical industry was not enough.Results and Conclusion Based on the MAH system,it is of great significance to establish the quality management system for pharmaceutical commissioned production.展开更多
BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological...BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological information in the included papers can often be lacking or unclear,and reviewers usually need to contact the authors of included studies for clarifications.Contacting authors is recommended,but it is unclear how often SR teams do it,or what the level of response is.AIM To investigate how often reviewers undertake contact with the authors of included randomized controlled trials(RCTs)for clarification on data and risk of bias concerns,to explore the factors that influence whether SR authors contact or do not contact the authors,and the content and level of responses.METHODS We conducted a systematic electronic database search in MEDLINE using the search string“(systematic review)”AND“(RCT OR randomized OR trial)”for articles published between 1 January 2024 and 19 February 2024,without language restrictions.Screening and data extraction was done independently by two reviewers,and conflicts resolved by a senior author.Contact authors of included SRs were contacted for clarifications.RESULTS Of the 329 included SRs,38%(n=125)explicitly mentioned contact with the authors of included studies.The remaining 62%(n=204)did not.We attempted contact with all SR teams for clarifications and received 90 responses(19.4%).Of the 50 respondents who did not explicitly mention contact in their SRs,25(50%)replied that they did make contact.We received a total of 64 responses on the level and content of information sought.The mean±SD contacts SR teams made were 10(10),replies received 5(6.7),and response waiting time 10.1(28.3)weeks.Resources,time,poor previous experience,perceived likelihood of poor response and bias concerns were reported as barriers to attempting contact.CONCLUSION The majority of SRs published in 2024 did not confirm seeking clarifying or missing information from primary study authors.However,SR teams reported that 50%of contacted primary authors respond.Additional research can clarify this rate of response and establish methods to increase the integration of this core methodological element in SRs.展开更多
According to the Charter of the United Nations,the United Nations Security Council adopts a“collective security system”authorized voting system,which has prominent drawbacks such as difficulty in fully reflecting th...According to the Charter of the United Nations,the United Nations Security Council adopts a“collective security system”authorized voting system,which has prominent drawbacks such as difficulty in fully reflecting the will of all Member States.Combining interdisciplinary,qualitative and quantitative research methods,in response to the dilemma of Security Council voting reform,this article suggests retaining the Security Council voting system and recommending a simplified model of“basic and weighted half”for voting allocation.This model not only inherits the authorized voting system of the collective security system,but also follows the allocation system of sovereignty equality in the Charter.It can also achieve the“draw on the advantages and avoid disadvantages”of Member States towards international development,promote the transformation of“absolute equality”of overall consistency into“real fairness”relative to individual contributions,and further promote the development of international law in the United Nations voting system.展开更多
Cyber-physical systems(CPSs)are increasingly vulnerable to cyber-attacks due to their integral connection between cyberspace and the physical world,which is augmented by Internet connectivity.This vulnerability necess...Cyber-physical systems(CPSs)are increasingly vulnerable to cyber-attacks due to their integral connection between cyberspace and the physical world,which is augmented by Internet connectivity.This vulnerability necessitates a heightened focus on developing resilient control mechanisms for CPSs.However,current observer-based active compensation resilient controllers exhibit poor performance against stealthy deception attacks(SDAs)due to the difficulty in accurately reconstructing system states because of the stealthy nature of these attacks.Moreover,some non-active compensation approaches are insufficient when there is a complete loss of actuator control authority.To address these issues,we introduce a novel learning-based passive resilient controller(LPRC).Our approach,unlike observer-based state reconstruction,shows enhanced effectiveness in countering SDAs.We developed a safety state set,represented by an ellipsoid,to ensure CPS stability under SDA conditions,maintaining system trajectories within this set.Additionally,by employing deep reinforcement learning(DRL),the LPRC acquires the capacity to adapt and diverse evolving attack strategies.To empirically substantiate our methodology,various attack methods were compared with current passive and active compensation resilient control methods to evaluate their performance.展开更多
Drug products are specific goods with safety and effectiveness in medical health case.All of researchers(authors),reviewers,and editors must abide by medical ethical obligation,and also must deter to the ethical oblig...Drug products are specific goods with safety and effectiveness in medical health case.All of researchers(authors),reviewers,and editors must abide by medical ethical obligation,and also must deter to the ethical obligation for publication.These guidelines are offered as ethical behavior standards.We now present a set of ethical guidelines for persons engaged in the publication of drug research,specifically,for editors,authors,and reviewers.We believe that the guidelines offered are understood and subscribed to by the pharmaceutical research scientists.They may be helpful to those who are related to the editors,authors,and reviewers of journal publication.展开更多
Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasu...Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.展开更多
International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and ...International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.展开更多
Contemporary Social Sciences is an English-language journal founded by Sichuan Academy of Social Sciences(SASS)in March 2016.It is China’s first and only English academic journal established by a local academy of soc...Contemporary Social Sciences is an English-language journal founded by Sichuan Academy of Social Sciences(SASS)in March 2016.It is China’s first and only English academic journal established by a local academy of social sciences,as well as Sichuan’s only English academic journal in humanities and social sciences with a CN serial number.As a publication run in line with the requirements of China’s press and publication authority,Contemporary Social Sciences publishes outstanding research in the field of social sciences in China and also includes high-quality research work by foreign scholars on the development of China’s western regions and its reform and opening up.The aim is to help promote China’s academic achievements to the world and give China a stronger voice in the global community of social sciences.展开更多
Community Question Answering （CQA） websites have greatly facilitated users＇ lives, with an increasing number of people seeking help and exchanging ideas on the Internet. This newlymerged community features two char...Community Question Answering （CQA） websites have greatly facilitated users＇ lives, with an increasing number of people seeking help and exchanging ideas on the Internet. This newlymerged community features two characteristics： social relations and an ask-reply mechanism. As users＇ behaviours and social statuses play a more important role in CQA services than traditional answer retrieving websites, researchers＇ concerns have shifted from the need to passively find existing answers to actively seeking potential reply providers that may give answers in the near future. We analyse datasets derived from an online CQA system named ＂Quora＂, and observed that compared with traditional question answering services, users tend to contribute replies rather than questions for help in the CQA system. Inspired by the findings, we seek ways to evaluate the users＇ ability to offer prompt and reliable help, taking into account activity, authority and social reputation char- acteristics. We propose a hybrid method that is based on a Question-User network and social network using optimised PageRank algorithm. Experimental results show the efficiency of the proposed method for ranking potential answer-providers.展开更多
文摘Purpose-This paper provides a comprehensive analysis of the Brazilian freight railway system,examining the efficacy of the current concession renewal model in light of persistent structural problems such as market concentration,cargo dependence on export commodities and underutilization of the network.Situating Brazil within the broader international debate on railway reforms,the paper evaluates whether the ongoing early renewal of concessions can deliver a more diversified and competitive freight system.Design/methodology/approach-The study adopts a sequential mixed-methods research design that integrates longitudinal quantitative analysis with qualitative institutional and policy evaluation.The quantitative component examines time-series indicators published by ANTT,DNIT and INFRA S.A.from 1999 to 2023 to identify structural patterns in traffic growth,investment,safety and market concentration.The qualitative component employs a process-tracing logic to reconstruct the evolution of concession renewals and the implementation of Railway Law 14.273/2021,drawing on concepts from regulatory economics,institutional theory and industrial organization.These empirical streams are synthesized through an analytical framework that connects three dimensions-regulatory design,market structure and system performance-allowing for a systematic assessment of how Brazil’s institutional configuration shapes incentives,competitive dynamics and network utilization.Findings-The analysis confirms that the early renewal of concessions has successfully secured substantial private investment for capacity expansion on existing trunk lines.However,it has perpetuated the vertically integrated model,reinforcing the market power of incumbent operators and failing to significantly promote intramodal competition or cargo diversification.The system remains dominated by iron ore and agricultural commodities,with general cargo representing a minuscule share.The new authorization regime and short-line railway policies present a viable pathway for market opening but face significant operational and institutional barriers to implementation.Originality/value-This research offers a timely and critical assessment of a pivotal moment in Brazilian railway policy.It moves beyond a simplistic evaluation of volume growth to a structural analysis of market failures and the interplay between concession renewal and regulatory innovation.The findings provide actionable insights for policymakers in Brazil and other emerging economies seeking to balance private investment with public interest goals in railway infrastructure,highlighting the necessity of complementary,pro-competitive measures alongside financial investment.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2022R1I1A3063257)supported by Electronics and Telecommunications Research Institute(ETRI)grant funded by the Korean Government[22ZR1300,Research on Intelligent Cyber Security and Trust Infra].
文摘These days,data is regarded as a valuable asset in the era of the data economy,which demands a trading platform for buying and selling data.However,online data trading poses challenges in terms of security and fairness because the seller and the buyer may not fully trust each other.Therefore,in this paper,a blockchain-based secure and fair data trading system is proposed by taking advantage of the smart contract and matchmaking encryption.The proposed system enables bilateral authorization,where data trading between a seller and a buyer is accomplished only if their policies,required by each other,are satisfied simultaneously.This can be achieved by exploiting the security features of the matchmaking encryption.To guarantee non-repudiation and fairness between trading parties,the proposed system leverages a smart contract to ensure that the parties honestly carry out the data trading protocol.However,the smart contract in the proposed system does not include complex cryptographic operations for the efficiency of onchain processes.Instead,these operations are carried out by off-chain parties and their results are used as input for the on-chain procedure.The system also uses an arbitration protocol to resolve disputes based on the trading proof recorded on the blockchain.The performance of the protocol is evaluated in terms of off-chain computation overhead and on-chain gas consumption.The results of the experiments demonstrate that the proposed protocols can enable the implementation of a cost-effective data trading system.
基金supported by the National Natural Science Foundation of China (Nos.50705084 and 60473129)the Science and Technology Plan of Zhejiang Province,China (No.2007C13018)
文摘The specification of authorization policies in access control models proposed so far cannot satisfy the requirements in workflow management systems(WFMSs).Furthermore,existing approaches have not provided effective conflict detection and resolution methods to maintain the consistency of authorization polices in WFMSs.To address these concerns,we propose the definition of authorization policies in which context constraints are considered and the complicated requirements in WFMSs can be satisfied.Based on the definition,we put forward static and dynamic conflict detection methods for authorization policies.By defining two new concepts,the precedence establishment rule and the conflict resolution policy,we provide a flexible approach to resolving conflicts.
基金supported by JSPS KAKENHI(Grant Number JP19K11963,JP22K17881,JP18K04133,and JP22H00550).
文摘User-centric data sharing is essential to encourage citizens'active participation in the digital economy.One key to smart cities,a form of the digital economy,is the promotion of public use of citizen data.Nevertheless,it is not easy to utilize data without citizens’consent.In this study,we took a technological approach to these issues.Usermanaged access(UMA)is a well-known framework for delegating resource access rights to others on the Internet.In UMA,authorization mechanisms are designed to be centralized so that resource owners can centrally manage access rights for various resources stored in different domains.However,the lack of transparency in the authorization mechanism is a barrier to its implementation in large-scale systems such as smart cities.In this study,we developed a blockchain-based cross-domain authorization architecture that enables a resource-sharing ecosystem in which organizations that wish to utilize data can freely trade with each other.The proposed architecture solves the transparency problem that conventional authorization systems have had by designing the authorization mechanism on blockchain technology.We implemented the proposed architecture as smart contracts and evaluated its processing performance.The resultant time required for delegating access rights and accessing resources was less than 500 ms.Furthermore,we found that the fluctuation in the processing time overhead was small.Based on these results,we concluded that performance degradation with the proposed architecture is minor.
基金Integration Application Status and Problems Investigation of ICH Q8,Q9,Q10 across the Product Life Cycle(No.20210605).
文摘Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.
文摘Should the article be accepted and published by Meteorological and Environmental Research , the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction, distribution, compilation and information network transmission rights.
文摘Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.
文摘Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,distribution,compilation and information network transmission rights.
文摘Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.
文摘Should the article be accepted and published by Meteorological and Environmental Research,the author hereby grants exclusively to the editorial department of Meteorological and Environmental Research the digital reproduction,distribution,compilation and information network transmission rights.
文摘Should the article be accepted and published by Agricultural Science&Technology,the author hereby grants exclusively to the editorial department of Agricultural Science&Technology the digital reproduction,distribution,compilation and information network transmission rights.
文摘Objective To ensure the quality and safety of drugs in the whole cycle of pharmaceutical commissioned production under the drug marketing authorization holder(MAH)system,and to establish a perfect quality management system for it.Methods Literature review was used to study the factors that influenced the quality management system of pharmaceutical commissioned production because the implementation of MAH system in China was late,and the experience accumulated by pharmaceutical industry was not enough.Results and Conclusion Based on the MAH system,it is of great significance to establish the quality management system for pharmaceutical commissioned production.
文摘BACKGROUND Systematic reviews(SRs)synthesize and evaluate data,mainly from randomized trials,which then guides the development of clinical recommendations in evidence-based medicine.However,the data and methodological information in the included papers can often be lacking or unclear,and reviewers usually need to contact the authors of included studies for clarifications.Contacting authors is recommended,but it is unclear how often SR teams do it,or what the level of response is.AIM To investigate how often reviewers undertake contact with the authors of included randomized controlled trials(RCTs)for clarification on data and risk of bias concerns,to explore the factors that influence whether SR authors contact or do not contact the authors,and the content and level of responses.METHODS We conducted a systematic electronic database search in MEDLINE using the search string“(systematic review)”AND“(RCT OR randomized OR trial)”for articles published between 1 January 2024 and 19 February 2024,without language restrictions.Screening and data extraction was done independently by two reviewers,and conflicts resolved by a senior author.Contact authors of included SRs were contacted for clarifications.RESULTS Of the 329 included SRs,38%(n=125)explicitly mentioned contact with the authors of included studies.The remaining 62%(n=204)did not.We attempted contact with all SR teams for clarifications and received 90 responses(19.4%).Of the 50 respondents who did not explicitly mention contact in their SRs,25(50%)replied that they did make contact.We received a total of 64 responses on the level and content of information sought.The mean±SD contacts SR teams made were 10(10),replies received 5(6.7),and response waiting time 10.1(28.3)weeks.Resources,time,poor previous experience,perceived likelihood of poor response and bias concerns were reported as barriers to attempting contact.CONCLUSION The majority of SRs published in 2024 did not confirm seeking clarifying or missing information from primary study authors.However,SR teams reported that 50%of contacted primary authors respond.Additional research can clarify this rate of response and establish methods to increase the integration of this core methodological element in SRs.
文摘According to the Charter of the United Nations,the United Nations Security Council adopts a“collective security system”authorized voting system,which has prominent drawbacks such as difficulty in fully reflecting the will of all Member States.Combining interdisciplinary,qualitative and quantitative research methods,in response to the dilemma of Security Council voting reform,this article suggests retaining the Security Council voting system and recommending a simplified model of“basic and weighted half”for voting allocation.This model not only inherits the authorized voting system of the collective security system,but also follows the allocation system of sovereignty equality in the Charter.It can also achieve the“draw on the advantages and avoid disadvantages”of Member States towards international development,promote the transformation of“absolute equality”of overall consistency into“real fairness”relative to individual contributions,and further promote the development of international law in the United Nations voting system.
基金supported by the National Natural Science Foundation of China(52332011).
文摘Cyber-physical systems(CPSs)are increasingly vulnerable to cyber-attacks due to their integral connection between cyberspace and the physical world,which is augmented by Internet connectivity.This vulnerability necessitates a heightened focus on developing resilient control mechanisms for CPSs.However,current observer-based active compensation resilient controllers exhibit poor performance against stealthy deception attacks(SDAs)due to the difficulty in accurately reconstructing system states because of the stealthy nature of these attacks.Moreover,some non-active compensation approaches are insufficient when there is a complete loss of actuator control authority.To address these issues,we introduce a novel learning-based passive resilient controller(LPRC).Our approach,unlike observer-based state reconstruction,shows enhanced effectiveness in countering SDAs.We developed a safety state set,represented by an ellipsoid,to ensure CPS stability under SDA conditions,maintaining system trajectories within this set.Additionally,by employing deep reinforcement learning(DRL),the LPRC acquires the capacity to adapt and diverse evolving attack strategies.To empirically substantiate our methodology,various attack methods were compared with current passive and active compensation resilient control methods to evaluate their performance.
文摘Drug products are specific goods with safety and effectiveness in medical health case.All of researchers(authors),reviewers,and editors must abide by medical ethical obligation,and also must deter to the ethical obligation for publication.These guidelines are offered as ethical behavior standards.We now present a set of ethical guidelines for persons engaged in the publication of drug research,specifically,for editors,authors,and reviewers.We believe that the guidelines offered are understood and subscribed to by the pharmaceutical research scientists.They may be helpful to those who are related to the editors,authors,and reviewers of journal publication.
基金Scientific Research Fund Project of Yunnan Provincial Department of Education(Project No.:2024J2130)。
文摘Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.
文摘International Journal of Minerals,Metallurgy and Materials is dedicated to the publication and the dissemination of original research articles (and occasional invited reviews) in the fields of Minerals,Metallurgy and Materials.It is covered by EI Compendex,SCI Expanded,Chemical Abstract,etc.Manuscript preparation The following components are required for a complete manuscript:Title,Author(s),Author affiliation(s),Abstract,Keywords,Main text,Acknowledgements and References.
文摘Contemporary Social Sciences is an English-language journal founded by Sichuan Academy of Social Sciences(SASS)in March 2016.It is China’s first and only English academic journal established by a local academy of social sciences,as well as Sichuan’s only English academic journal in humanities and social sciences with a CN serial number.As a publication run in line with the requirements of China’s press and publication authority,Contemporary Social Sciences publishes outstanding research in the field of social sciences in China and also includes high-quality research work by foreign scholars on the development of China’s western regions and its reform and opening up.The aim is to help promote China’s academic achievements to the world and give China a stronger voice in the global community of social sciences.
基金supported by the Fundamental Research Funds for the Central Universitiesthe National Natural Science Foundation of China under Grant No.61271041+2 种基金the National Basic Research Program of China (973 Program) under Grant No.2009CB320504the iCore Integrated Project under Grant No.287708the National Scienceand Technology Major Project under Grants No.2012ZX03005008-001,No.2012ZX03002008
文摘Community Question Answering （CQA） websites have greatly facilitated users＇ lives, with an increasing number of people seeking help and exchanging ideas on the Internet. This newlymerged community features two characteristics： social relations and an ask-reply mechanism. As users＇ behaviours and social statuses play a more important role in CQA services than traditional answer retrieving websites, researchers＇ concerns have shifted from the need to passively find existing answers to actively seeking potential reply providers that may give answers in the near future. We analyse datasets derived from an online CQA system named ＂Quora＂, and observed that compared with traditional question answering services, users tend to contribute replies rather than questions for help in the CQA system. Inspired by the findings, we seek ways to evaluate the users＇ ability to offer prompt and reliable help, taking into account activity, authority and social reputation char- acteristics. We propose a hybrid method that is based on a Question-User network and social network using optimised PageRank algorithm. Experimental results show the efficiency of the proposed method for ranking potential answer-providers.
