With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the c...With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the college English audio-visual oral course not only imparts language knowledge and skills,but also shoulders the important task of cultivating students’critical thinking.As one of the essential core qualities of modern talents,critical thinking ability plays an irreplaceable role in students’in-depth understanding of English knowledge,improving intercultural communication ability and cultivating innovative thinking.This paper expounds the significance of cultivating students’critical thinking ability in college English audio-visual and oral teaching,and puts forward a series of innovative teaching strategies to cultivate students’critical thinking ability combined with practical teaching experience and cutting-edge education theory,in order to provide new ideas and practical guidance for the improvement of college English teaching quality and the development of students’comprehensive quality.展开更多
Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disruptin...Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons.展开更多
Audio-visual learning,aimed at exploiting the relationship between audio and visual modalities,has drawn considerable attention since deep learning started to be used successfully.Researchers tend to leverage these tw...Audio-visual learning,aimed at exploiting the relationship between audio and visual modalities,has drawn considerable attention since deep learning started to be used successfully.Researchers tend to leverage these two modalities to improve the performance of previously considered single-modality tasks or address new challenging problems.In this paper,we provide a comprehensive survey of recent audio-visual learning development.We divide the current audio-visual learning tasks into four different subfields:audiovisual separation and localization,audio-visual correspondence learning,audio-visual generation,and audio-visual representation learning.State-of-the-art methods,as well as the remaining challenges of each subfield,are further discussed.Finally,we summarize the commonly used datasets and challenges.展开更多
Video data are composed of multimodal information streams including visual, auditory and textual streams, so an approach of story segmentation for news video using multimodal analysis is described in this paper. The p...Video data are composed of multimodal information streams including visual, auditory and textual streams, so an approach of story segmentation for news video using multimodal analysis is described in this paper. The proposed approach detects the topic-caption frames, and integrates them with silence clips detection results, as well as shot segmentation results to locate the news story boundaries. The integration of audio-visual features and text information overcomes the weakness of the approach using only image analysis techniques. On test data with 135 400 frames, when the boundaries between news stories are detected, the accuracy rate 85.8% and the recall rate 97.5% are obtained. The experimental results show the approach is valid and robust.展开更多
In response to the evolving challenges posed by small unmanned aerial vehicles(UAVs),which have the potential to transport harmful payloads or cause significant damage,we present AV-FDTI,an innovative Audio-Visual Fus...In response to the evolving challenges posed by small unmanned aerial vehicles(UAVs),which have the potential to transport harmful payloads or cause significant damage,we present AV-FDTI,an innovative Audio-Visual Fusion system designed for Drone Threat Identification.AV-FDTI leverages the fusion of audio and omnidirectional camera feature inputs,providing a comprehensive solution to enhance the precision and resilience of drone classification and 3D localization.Specifically,AV-FDTI employs a CRNN network to capture vital temporal dynamics within the audio domain and utilizes a pretrained ResNet50 model for image feature extraction.Furthermore,we adopt a visual information entropy and cross-attention-based mechanism to enhance the fusion of visual and audio data.Notably,our system is trained based on automated Leica tracking annotations,offering accurate ground truth data with millimeter-level accuracy.Comprehensive comparative evaluations demonstrate the superiority of our solution over the existing systems.In our commitment to advancing this field,we will release this work as open-source code and wearable AV-FDTI design,contributing valuable resources to the research community.展开更多
This paper is dedicated to a thorough review on the audio-visual related translations from both home and abroad.In reviewing the foreign achievements on this specific field of translation studies it can shed some ligh...This paper is dedicated to a thorough review on the audio-visual related translations from both home and abroad.In reviewing the foreign achievements on this specific field of translation studies it can shed some lights on our national audio-visual practice and research.The review on the Chinese scholars’ audio-visual translation studies is to offer the potential developing direction and guidelines to the studies and aspects neglected as well.Based on the summary of relevant studies,possible topics for further studies are proposed.展开更多
Emotion recognition has become an important task of modern human-computer interac- tion. A multilayer boosted HMM （ MBHMM ） classifier for automatic audio-visual emotion recognition is presented in this paper. A mod...Emotion recognition has become an important task of modern human-computer interac- tion. A multilayer boosted HMM （ MBHMM ） classifier for automatic audio-visual emotion recognition is presented in this paper. A modified Baum-Welch algorithm is proposed for component HMM learn- ing and adaptive boosting （AdaBoost） is used to train ensemble classifiers for different layers （cues）. Except for the first layer, the initial weights of training samples in current layer are decided by recognition results of the ensemble classifier in the upper layer. Thus the training procedure using current cue can focus more on the difficult samples according to the previous cue. Our MBHMM clas- sifier is combined by these ensemble classifiers and takes advantage of the complementary informa- tion from multiple cues and modalities. Experimental results on audio-visual emotion data collected in Wizard of Oz scenarios and labeled under two types of emotion category sets demonstrate that our approach is effective and promising.展开更多
February 10 (US Central Time), 2019, China National Peking Opera Company (CNPOC) and the Hubei Chime Bells National Chinese Orchestra presented a fantastic audio-visual performance of Chinese Peking Opera and Chinese ...February 10 (US Central Time), 2019, China National Peking Opera Company (CNPOC) and the Hubei Chime Bells National Chinese Orchestra presented a fantastic audio-visual performance of Chinese Peking Opera and Chinese chime bells for the American audience at the world s top-level Buntrock Hall at Symphony Center.展开更多
Mongolian audio-visual works are an important carrier of exploring the true significance to this national culture.This paper believes that the Mongolian people in Inner Mongolia constantly enhance the individual sense...Mongolian audio-visual works are an important carrier of exploring the true significance to this national culture.This paper believes that the Mongolian people in Inner Mongolia constantly enhance the individual sense of identity to the overall ethnic group through the influence of film and television and music,and on this basis constantly evolve a new culture in line with modern and contemporary life to further enhance their sense of belonging to the ethnic nation.展开更多
Based on the current situation of college audio-visual English teaching in China, this article points out that the avoidance in class is a serious phenomenon in the process of college audio-visual English teaching. Af...Based on the current situation of college audio-visual English teaching in China, this article points out that the avoidance in class is a serious phenomenon in the process of college audio-visual English teaching. After further analysis and combination with the characteristics of college English audio-visual teaching in China, it puts forward the application of task-based teaching method to college audio-visual English teaching and its steps, attempting to alleviate the avoidance phenomenon in students through task-based teaching method.展开更多
Zhuang culture,a representative of the native ethnic culture of Guangxi,China,is of great significance to Chinese culture.In order to promote traditional culture,enrich the teaching content of College English Audio-Vi...Zhuang culture,a representative of the native ethnic culture of Guangxi,China,is of great significance to Chinese culture.In order to promote traditional culture,enrich the teaching content of College English Audio-Visual Speaking Course,and enhance the intercultural communication ability of college students,this paper,from a multicultural perspective,explores the classroom practices of integrating indigenous Zhuang cultural elements in College English Audio-Visual Speaking Course,providing new perspectives and reference for multicultural education in foreign languages.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in th...BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor microenvir-onment.Inflammation regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy efficacy.Interleukin-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different tumors.We hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in HCC.The upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow cytometry.Mechanistic studies were conducted with gene knockout models and pathway inhibitors.The function of IL-17A in immune evasion was explored through coculture of T cells and HCC cells.The effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in vivo.RESULTS IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by IL-17A.IL-17A enhanced the survival of HCC cells in the coculture system.IL-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic index.Cyclin D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression decreased.The combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse model.CONCLUSION IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against decapenta-plegic 2 signaling pathway in HCC cells.Blocking IL-17A enhances the therapeutic efficacy of PD-L1 antibodies in HCC in vivo.展开更多
By distinguishing the differences between audio-visual interpretation and visual interpretation, it is clear that the two belong to different categories in essence and working methods, in order to avoid misunderstandi...By distinguishing the differences between audio-visual interpretation and visual interpretation, it is clear that the two belong to different categories in essence and working methods, in order to avoid misunderstanding and confusion between the two in learning. At the same time, there are some misconceptions in their teaching methods. This paper explores the teaching methods of visual interpretation and audio-visual interpretation, which will make them more reasonable and scientific in the teaching process.展开更多
BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a ...BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a crucial biomarker for predicting the efficacy of immune checkpoint inhibitors in cancer treatment.While HP infection and PD-L1 expression in GC may be linked,the relationship between them remains unclear,in part because there have been conflicting results reported from various studies.AIM To perform a meta-analysis to assess the relationship between HP and PD-L1 expression in patients with GC.METHODS A systematic literature review was conducted using PubMed,Embase,Cochrane Library,and Web of Science databases.Observational studies that examined the association between HP infection and PD-L1 expression in patients with GC were included.Odds ratios and 95%confidence intervals were calculated to estimate the association.Heterogeneity was assessed using Cochrane’s Q test and I²statistic.A random-effects model was used due to significant heterogeneity across studies.RESULTS Fourteen studies involving a total of 3069 patients with GC were included.The pooled analysis showed a significant association between HP infection and increased PD-L1 expression in GC tissues(odd ratio=1.69,95%confidence interval:1.24-2.29,P<0.001,I^(2)=59%).Sensitivity analyses confirmed the robustness of these findings.Subgroup analyses did not show significant variation based on geographic region,sample size,or method of PD-L1 assessment.Publication bias was minimal,as shown by funnel plots and Egger’s regression test.CONCLUSION HP infection is associated with increased PD-L1 expression in GC,suggesting that HP status may influence the response to programmed cell death protein 1/PD-L1 blockade therapy.展开更多
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c...Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.展开更多
The object-based scalable coding in MPEG-4 is investigated, and a prioritized transmission scheme of MPEG-4 audio-visual objects （AVOs） over the DiffServ network with the QoS guarantee is proposed. MPEG-4 AVOs are e...The object-based scalable coding in MPEG-4 is investigated, and a prioritized transmission scheme of MPEG-4 audio-visual objects （AVOs） over the DiffServ network with the QoS guarantee is proposed. MPEG-4 AVOs are extracted and classified into different groups according to their priority values and scalable layers （visual importance）. These priority values are mapped to the 1P DiffServ per hop behaviors （PHB）. This scheme can selectively discard packets with low importance, in order to avoid the network congestion. Simulation results show that the quality of received video can gracefully adapt to network state, as compared with the ‘best-effort＇ manner. Also, by allowing the content provider to define prioritization of each audio-visual object, the adaptive transmission of object-based scalable video can be customized based on the content.展开更多
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functio...The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.展开更多
BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression i...BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression is programmed death ligand 1(PD-L1).Previously,we investigated PD-L1 expression in BC via a new antibody against programmed cell death protein 1 ligand 1(PDCD1 LG1)and reported that high PDCD1 LG1 expression in tumor cells is an independent factor for a high risk of regional metastasis in patients with BC.However,the prognostic significance of PDCD1 LG1 expression in BC stromal cells has not been adequately studied.AIM To study the features of PDCD1 LG1 expression in BC stromal cells and its relationship with BC clinicopathological characteristics.METHODS In a prospective single-center observational study,tumor samples from 148 patients with newly diagnosed BC were examined.The tumor sections were immunohistochemically stained with antibodies against PDCD1 LG1.In the tumor samples,the PDCD1 LG1-positive lymphocyte(PDCD1 LG1+LF)score,presence of nuclear PDCD1 LG1 expression in the LFs,PDCD1 LG1 expression in polymorphic cell infiltrates(PDCD1 LG1+polymorphic cell infiltrates[PCIs]),and cells of the fibroblastic stroma and endothelial cells of the tumor microvessels were assessed.Statistical analyses were performed using Statistica 10.0 software.RESULTS A PDCD1 LG1+LF score≥3 was detected more often at stages N0 and N3 than at N1 and N2(P=0.03).Moderate and pronounced PDCD1 LG1+PCIs and the presence of PDCD1 LG1+fibroblastic stroma were associated with negative estrogen receptor status(P=0.0008 and P=0.03,respectively),human epidermal growth factor receptor 2-positive(HER2+)BC(P<0.00001 and P=0.0005),and luminal B HER2+,non-luminal HER2+and triple-negative BC(P<0.00001 and P=0.004).The risk of metastasis to regional lymph nodes(RLNs)depend on lymphovascular invasion(LVI)and the PDCD1 LG1+LF score.In the absence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were absent in 66.6%and 93.9%of patients with BC,respectively.In the presence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were detected in 82.6%and 92.7%of patients with BC,respectively.CONCLUSION The results indicated that the combined assessment of the PDCD1 LG1+LF score and LVI can improve the accuracy of predicting the risk of metastasis to RLNs in patients with BC.展开更多
Generating dynamically feasible trajectory for fixed-wing Unmanned Aerial Vehicles(UAVs)in dense obstacle environments remains computationally intractable.This paper proposes a Safe Flight Corridor constrained Sequent...Generating dynamically feasible trajectory for fixed-wing Unmanned Aerial Vehicles(UAVs)in dense obstacle environments remains computationally intractable.This paper proposes a Safe Flight Corridor constrained Sequential Convex Programming(SFC-SCP)to improve the computation efficiency and reliability of trajectory generation.SFC-SCP combines the front-end convex polyhedron SFC construction and back-end SCP-based trajectory optimization.A Sparse A^(*)Search(SAS)driven SFC construction method is designed to efficiently generate polyhedron SFC according to the geometric relation among obstacles and collision-free waypoints.Via transforming the nonconvex obstacle-avoidance constraints to linear inequality constraints,SFC can mitigate infeasibility of trajectory planning and reduce computation complexity.Then,SCP casts the nonlinear trajectory optimization subject to SFC into convex programming subproblems to decrease the problem complexity.In addition,a convex optimizer based on interior point method is customized,where the search direction is calculated via successive elimination to further improve efficiency.Simulation experiments on dense obstacle scenarios show that SFC-SCP can generate dynamically feasible safe trajectory rapidly.Comparative studies with state-of-the-art SCP-based methods demonstrate the efficiency and reliability merits of SFC-SCP.Besides,the customized convex optimizer outperforms off-the-shelf optimizers in terms of computation time.展开更多
Deep-time Earth research plays a pivotal role in deciphering the rates,patterns,and mechanisms of Earth's evolutionary processes throughout geological history,providing essential scientific foundations for climate...Deep-time Earth research plays a pivotal role in deciphering the rates,patterns,and mechanisms of Earth's evolutionary processes throughout geological history,providing essential scientific foundations for climate prediction,natural resource exploration,and sustainable planetary stewardship.To advance Deep-time Earth research in the era of big data and artificial intelligence,the International Union of Geological Sciences initiated the“Deeptime Digital Earth International Big Science Program”(DDE)in 2019.At the core of this ambitious program lies the development of geoscience knowledge graphs,serving as a transformative knowledge infrastructure that enables the integration,sharing,mining,and analysis of heterogeneous geoscience big data.The DDE knowledge graph initiative has made significant strides in three critical dimensions:(1)establishing a unified knowledge structure across geoscience disciplines that ensures consistent representation of geological entities and their interrelationships through standardized ontologies and semantic frameworks;(2)developing a robust and scalable software infrastructure capable of supporting both expert-driven and machine-assisted knowledge engineering for large-scale graph construction and management;(3)implementing a comprehensive three-tiered architecture encompassing basic,discipline-specific,and application-oriented knowledge graphs,spanning approximately 20 geoscience disciplines.Through its open knowledge framework and international collaborative network,this initiative has fostered multinational research collaborations,establishing a robust foundation for next-generation geoscience research while propelling the discipline toward FAIR(Findable,Accessible,Interoperable,Reusable)data practices in deep-time Earth systems research.展开更多
基金A Study on the Teaching Reform of College English Audio-Visual Oral Course Oriented towards the Cultivation of Critical Thinking Ability(2501032339)。
文摘With the increasingly prominent trend of globalization,English,as the common language of international communication,plays an increasingly important role in university education.As a key link in English teaching,the college English audio-visual oral course not only imparts language knowledge and skills,but also shoulders the important task of cultivating students’critical thinking.As one of the essential core qualities of modern talents,critical thinking ability plays an irreplaceable role in students’in-depth understanding of English knowledge,improving intercultural communication ability and cultivating innovative thinking.This paper expounds the significance of cultivating students’critical thinking ability in college English audio-visual and oral teaching,and puts forward a series of innovative teaching strategies to cultivate students’critical thinking ability combined with practical teaching experience and cutting-edge education theory,in order to provide new ideas and practical guidance for the improvement of college English teaching quality and the development of students’comprehensive quality.
基金financially supported by Ministerio de Ciencia e Innovación projects SAF2017-82736-C2-1-R to MTMFin Universidad Autónoma de Madrid and by Fundación Universidad Francisco de Vitoria to JS+2 种基金a predoctoral scholarship from Fundación Universidad Francisco de Vitoriafinancial support from a 6-month contract from Universidad Autónoma de Madrida 3-month contract from the School of Medicine of Universidad Francisco de Vitoria。
文摘Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury(SCI). SCI is a devastating medical condition that arises from trauma or disease-induced damage to the spinal cord, disrupting the neural connections that allow communication between the brain and the rest of the body, which results in varying degrees of motor and sensory impairment. Disconnection in the spinal tracts is an irreversible condition owing to the poor capacity for spontaneous axonal regeneration in the affected neurons.
基金supported by National Key Research and Development Program of China(No.2016YFB1001001)Beijing Natural Science Foundation(No.JQ18017)National Natural Science Foundation of China(No.61976002)。
文摘Audio-visual learning,aimed at exploiting the relationship between audio and visual modalities,has drawn considerable attention since deep learning started to be used successfully.Researchers tend to leverage these two modalities to improve the performance of previously considered single-modality tasks or address new challenging problems.In this paper,we provide a comprehensive survey of recent audio-visual learning development.We divide the current audio-visual learning tasks into four different subfields:audiovisual separation and localization,audio-visual correspondence learning,audio-visual generation,and audio-visual representation learning.State-of-the-art methods,as well as the remaining challenges of each subfield,are further discussed.Finally,we summarize the commonly used datasets and challenges.
文摘Video data are composed of multimodal information streams including visual, auditory and textual streams, so an approach of story segmentation for news video using multimodal analysis is described in this paper. The proposed approach detects the topic-caption frames, and integrates them with silence clips detection results, as well as shot segmentation results to locate the news story boundaries. The integration of audio-visual features and text information overcomes the weakness of the approach using only image analysis techniques. On test data with 135 400 frames, when the boundaries between news stories are detected, the accuracy rate 85.8% and the recall rate 97.5% are obtained. The experimental results show the approach is valid and robust.
基金National Research Foundation,Singapore,under its Medium-Sized Center for Advanced Robotics Technology Innovation(CARTIN)under project WP5 within the Delta-NTU Corporate Lab with funding support from A*STAR under its IAF-ICP program(Grant no:I2201E0013)and Delta Electronics Inc.
文摘In response to the evolving challenges posed by small unmanned aerial vehicles(UAVs),which have the potential to transport harmful payloads or cause significant damage,we present AV-FDTI,an innovative Audio-Visual Fusion system designed for Drone Threat Identification.AV-FDTI leverages the fusion of audio and omnidirectional camera feature inputs,providing a comprehensive solution to enhance the precision and resilience of drone classification and 3D localization.Specifically,AV-FDTI employs a CRNN network to capture vital temporal dynamics within the audio domain and utilizes a pretrained ResNet50 model for image feature extraction.Furthermore,we adopt a visual information entropy and cross-attention-based mechanism to enhance the fusion of visual and audio data.Notably,our system is trained based on automated Leica tracking annotations,offering accurate ground truth data with millimeter-level accuracy.Comprehensive comparative evaluations demonstrate the superiority of our solution over the existing systems.In our commitment to advancing this field,we will release this work as open-source code and wearable AV-FDTI design,contributing valuable resources to the research community.
文摘This paper is dedicated to a thorough review on the audio-visual related translations from both home and abroad.In reviewing the foreign achievements on this specific field of translation studies it can shed some lights on our national audio-visual practice and research.The review on the Chinese scholars’ audio-visual translation studies is to offer the potential developing direction and guidelines to the studies and aspects neglected as well.Based on the summary of relevant studies,possible topics for further studies are proposed.
基金Supported by the National Natural Science Foundation of China(60905006)the NSFC-Guangdong Joint Fund(U1035004)
文摘Emotion recognition has become an important task of modern human-computer interac- tion. A multilayer boosted HMM （ MBHMM ） classifier for automatic audio-visual emotion recognition is presented in this paper. A modified Baum-Welch algorithm is proposed for component HMM learn- ing and adaptive boosting （AdaBoost） is used to train ensemble classifiers for different layers （cues）. Except for the first layer, the initial weights of training samples in current layer are decided by recognition results of the ensemble classifier in the upper layer. Thus the training procedure using current cue can focus more on the difficult samples according to the previous cue. Our MBHMM clas- sifier is combined by these ensemble classifiers and takes advantage of the complementary informa- tion from multiple cues and modalities. Experimental results on audio-visual emotion data collected in Wizard of Oz scenarios and labeled under two types of emotion category sets demonstrate that our approach is effective and promising.
文摘February 10 (US Central Time), 2019, China National Peking Opera Company (CNPOC) and the Hubei Chime Bells National Chinese Orchestra presented a fantastic audio-visual performance of Chinese Peking Opera and Chinese chime bells for the American audience at the world s top-level Buntrock Hall at Symphony Center.
基金This paper is the periodic research result of the research project:Basic Research Project of Beijing Institute of Graphic Communication:Research on the Artistic,Modern Communication and Publishing of Dian-shi Zhai Pictorial(1884-1898)(Serial Number Eb202008).
文摘Mongolian audio-visual works are an important carrier of exploring the true significance to this national culture.This paper believes that the Mongolian people in Inner Mongolia constantly enhance the individual sense of identity to the overall ethnic group through the influence of film and television and music,and on this basis constantly evolve a new culture in line with modern and contemporary life to further enhance their sense of belonging to the ethnic nation.
文摘Based on the current situation of college audio-visual English teaching in China, this article points out that the avoidance in class is a serious phenomenon in the process of college audio-visual English teaching. After further analysis and combination with the characteristics of college English audio-visual teaching in China, it puts forward the application of task-based teaching method to college audio-visual English teaching and its steps, attempting to alleviate the avoidance phenomenon in students through task-based teaching method.
基金supported by Guangxi University of Chinese Medicine School-Level Education and Teaching Reform and Research Project:Integration and Innovative Practice of Ideological and Political Education and Zhuang Ethnic Culture in College English Audio-Visual Speaking Course(Project No.2022B073).
文摘Zhuang culture,a representative of the native ethnic culture of Guangxi,China,is of great significance to Chinese culture.In order to promote traditional culture,enrich the teaching content of College English Audio-Visual Speaking Course,and enhance the intercultural communication ability of college students,this paper,from a multicultural perspective,explores the classroom practices of integrating indigenous Zhuang cultural elements in College English Audio-Visual Speaking Course,providing new perspectives and reference for multicultural education in foreign languages.
基金Supported by the Natural Science Foundation of Gansu Province,No.21JR7RA373 and No.24JRRA295.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal prognosis.Immunotherapy has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor microenvir-onment.Inflammation regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy efficacy.Interleukin-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different tumors.We hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in HCC.The upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow cytometry.Mechanistic studies were conducted with gene knockout models and pathway inhibitors.The function of IL-17A in immune evasion was explored through coculture of T cells and HCC cells.The effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in vivo.RESULTS IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by IL-17A.IL-17A enhanced the survival of HCC cells in the coculture system.IL-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic index.Cyclin D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression decreased.The combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse model.CONCLUSION IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against decapenta-plegic 2 signaling pathway in HCC cells.Blocking IL-17A enhances the therapeutic efficacy of PD-L1 antibodies in HCC in vivo.
文摘By distinguishing the differences between audio-visual interpretation and visual interpretation, it is clear that the two belong to different categories in essence and working methods, in order to avoid misunderstanding and confusion between the two in learning. At the same time, there are some misconceptions in their teaching methods. This paper explores the teaching methods of visual interpretation and audio-visual interpretation, which will make them more reasonable and scientific in the teaching process.
文摘BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a crucial biomarker for predicting the efficacy of immune checkpoint inhibitors in cancer treatment.While HP infection and PD-L1 expression in GC may be linked,the relationship between them remains unclear,in part because there have been conflicting results reported from various studies.AIM To perform a meta-analysis to assess the relationship between HP and PD-L1 expression in patients with GC.METHODS A systematic literature review was conducted using PubMed,Embase,Cochrane Library,and Web of Science databases.Observational studies that examined the association between HP infection and PD-L1 expression in patients with GC were included.Odds ratios and 95%confidence intervals were calculated to estimate the association.Heterogeneity was assessed using Cochrane’s Q test and I²statistic.A random-effects model was used due to significant heterogeneity across studies.RESULTS Fourteen studies involving a total of 3069 patients with GC were included.The pooled analysis showed a significant association between HP infection and increased PD-L1 expression in GC tissues(odd ratio=1.69,95%confidence interval:1.24-2.29,P<0.001,I^(2)=59%).Sensitivity analyses confirmed the robustness of these findings.Subgroup analyses did not show significant variation based on geographic region,sample size,or method of PD-L1 assessment.Publication bias was minimal,as shown by funnel plots and Egger’s regression test.CONCLUSION HP infection is associated with increased PD-L1 expression in GC,suggesting that HP status may influence the response to programmed cell death protein 1/PD-L1 blockade therapy.
基金supported by Canada First Research Excellence Fund,Medicine by Design(to CMM)。
文摘Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.
文摘The object-based scalable coding in MPEG-4 is investigated, and a prioritized transmission scheme of MPEG-4 audio-visual objects （AVOs） over the DiffServ network with the QoS guarantee is proposed. MPEG-4 AVOs are extracted and classified into different groups according to their priority values and scalable layers （visual importance）. These priority values are mapped to the 1P DiffServ per hop behaviors （PHB）. This scheme can selectively discard packets with low importance, in order to avoid the network congestion. Simulation results show that the quality of received video can gracefully adapt to network state, as compared with the ‘best-effort＇ manner. Also, by allowing the content provider to define prioritization of each audio-visual object, the adaptive transmission of object-based scalable video can be customized based on the content.
基金supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA)National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA)Department of Defense(DoD)grant AZ210089(to KMA)。
文摘The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Moraws ki et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.
基金Supported by Russian Science Foundation,No.23-25-00183.
文摘BACKGROUND Breast cancer(BC)continues to occupy a leading position in terms of morbidity and mortality from malignant neoplasms among the female population.One of the promising markers associated with BC progression is programmed death ligand 1(PD-L1).Previously,we investigated PD-L1 expression in BC via a new antibody against programmed cell death protein 1 ligand 1(PDCD1 LG1)and reported that high PDCD1 LG1 expression in tumor cells is an independent factor for a high risk of regional metastasis in patients with BC.However,the prognostic significance of PDCD1 LG1 expression in BC stromal cells has not been adequately studied.AIM To study the features of PDCD1 LG1 expression in BC stromal cells and its relationship with BC clinicopathological characteristics.METHODS In a prospective single-center observational study,tumor samples from 148 patients with newly diagnosed BC were examined.The tumor sections were immunohistochemically stained with antibodies against PDCD1 LG1.In the tumor samples,the PDCD1 LG1-positive lymphocyte(PDCD1 LG1+LF)score,presence of nuclear PDCD1 LG1 expression in the LFs,PDCD1 LG1 expression in polymorphic cell infiltrates(PDCD1 LG1+polymorphic cell infiltrates[PCIs]),and cells of the fibroblastic stroma and endothelial cells of the tumor microvessels were assessed.Statistical analyses were performed using Statistica 10.0 software.RESULTS A PDCD1 LG1+LF score≥3 was detected more often at stages N0 and N3 than at N1 and N2(P=0.03).Moderate and pronounced PDCD1 LG1+PCIs and the presence of PDCD1 LG1+fibroblastic stroma were associated with negative estrogen receptor status(P=0.0008 and P=0.03,respectively),human epidermal growth factor receptor 2-positive(HER2+)BC(P<0.00001 and P=0.0005),and luminal B HER2+,non-luminal HER2+and triple-negative BC(P<0.00001 and P=0.004).The risk of metastasis to regional lymph nodes(RLNs)depend on lymphovascular invasion(LVI)and the PDCD1 LG1+LF score.In the absence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were absent in 66.6%and 93.9%of patients with BC,respectively.In the presence of LVI and a PDCD1 LG1+LF score<3 or≥3,metastases in RLNs were detected in 82.6%and 92.7%of patients with BC,respectively.CONCLUSION The results indicated that the combined assessment of the PDCD1 LG1+LF score and LVI can improve the accuracy of predicting the risk of metastasis to RLNs in patients with BC.
基金supported by the National Natural Science Foundation of China(No.62203256)。
文摘Generating dynamically feasible trajectory for fixed-wing Unmanned Aerial Vehicles(UAVs)in dense obstacle environments remains computationally intractable.This paper proposes a Safe Flight Corridor constrained Sequential Convex Programming(SFC-SCP)to improve the computation efficiency and reliability of trajectory generation.SFC-SCP combines the front-end convex polyhedron SFC construction and back-end SCP-based trajectory optimization.A Sparse A^(*)Search(SAS)driven SFC construction method is designed to efficiently generate polyhedron SFC according to the geometric relation among obstacles and collision-free waypoints.Via transforming the nonconvex obstacle-avoidance constraints to linear inequality constraints,SFC can mitigate infeasibility of trajectory planning and reduce computation complexity.Then,SCP casts the nonlinear trajectory optimization subject to SFC into convex programming subproblems to decrease the problem complexity.In addition,a convex optimizer based on interior point method is customized,where the search direction is calculated via successive elimination to further improve efficiency.Simulation experiments on dense obstacle scenarios show that SFC-SCP can generate dynamically feasible safe trajectory rapidly.Comparative studies with state-of-the-art SCP-based methods demonstrate the efficiency and reliability merits of SFC-SCP.Besides,the customized convex optimizer outperforms off-the-shelf optimizers in terms of computation time.
基金Strategic Priority Research Program of the Chinese Academy of Sciences,No.XDB0740000National Key Research and Development Program of China,No.2022YFB3904200,No.2022YFF0711601+1 种基金Key Project of Innovation LREIS,No.PI009National Natural Science Foundation of China,No.42471503。
文摘Deep-time Earth research plays a pivotal role in deciphering the rates,patterns,and mechanisms of Earth's evolutionary processes throughout geological history,providing essential scientific foundations for climate prediction,natural resource exploration,and sustainable planetary stewardship.To advance Deep-time Earth research in the era of big data and artificial intelligence,the International Union of Geological Sciences initiated the“Deeptime Digital Earth International Big Science Program”(DDE)in 2019.At the core of this ambitious program lies the development of geoscience knowledge graphs,serving as a transformative knowledge infrastructure that enables the integration,sharing,mining,and analysis of heterogeneous geoscience big data.The DDE knowledge graph initiative has made significant strides in three critical dimensions:(1)establishing a unified knowledge structure across geoscience disciplines that ensures consistent representation of geological entities and their interrelationships through standardized ontologies and semantic frameworks;(2)developing a robust and scalable software infrastructure capable of supporting both expert-driven and machine-assisted knowledge engineering for large-scale graph construction and management;(3)implementing a comprehensive three-tiered architecture encompassing basic,discipline-specific,and application-oriented knowledge graphs,spanning approximately 20 geoscience disciplines.Through its open knowledge framework and international collaborative network,this initiative has fostered multinational research collaborations,establishing a robust foundation for next-generation geoscience research while propelling the discipline toward FAIR(Findable,Accessible,Interoperable,Reusable)data practices in deep-time Earth systems research.
