Today＇s production systems are demanded to exhibit an increased flexibility and mutability in order to deal with dynamically changing conditions, objectives and an increasing number of product variants within industr...Today＇s production systems are demanded to exhibit an increased flexibility and mutability in order to deal with dynamically changing conditions, objectives and an increasing number of product variants within industrial turbulent environments. Flexible automated systems are requested in order to improve dynamic production efficiency, e.g. robot-based hardware and PC-based controllers, but these usually induce a significantly higher production complexity, whereby the efforts for planning and programming, but also setups and reconfiguration, expand. In this paper a definition and some concepts of self-optimizing assembly systems are presented to describe possible ways to reduce the planning efforts in complex production systems. The concept of self-optimization in assembly systems will be derived from a theoretical approach and will be transferred to a specific application scenario---the automated assembly of a miniaturized solid state laser--where the challenges of unpredictable influences from e.g. component tolerances can be overcome by the help of self-optimization.展开更多
In recent years, cancer has become the number two cause of death around the world, and scientists have exploited various treatment maps. Calixarenes, with diversified features, have been widely applied into drug deliv...In recent years, cancer has become the number two cause of death around the world, and scientists have exploited various treatment maps. Calixarenes, with diversified features, have been widely applied into drug delivery systems, which can respond to multi-stimuli and exhibit excellent performance. In this mini-review, we summarize the recent advances on controlled drug delivery systems based on calixarenes, in the form of inclusion complexes, amphiphilic self-assembly nanocarriers including micelles, hydrogels, vesicles and liposomes, and supramolecular nanovalves on mesoporous silica nanomaterials.展开更多
The rapid advancement of synthetic biology and nanoscience has given rise to a new research field,known as nanoscale synthetic biology(NSB).This field emphasizes the interactions and coordination within entire biologi...The rapid advancement of synthetic biology and nanoscience has given rise to a new research field,known as nanoscale synthetic biology(NSB).This field emphasizes the interactions and coordination within entire biological systems,with the goal of achieving more efficient and controllable biological engineering through nanoscale manipulation.Nanocarriers facilitate the delivery of gene-regulating systems(such as CRISPR,mRNA,siRNA,and plasmids),nanozymes,drugs,and specific nanoprobes,enabling precise control over gene expression,modulation of biological metabolism,and monitoring of synthesized products in various organisms(including cells,bacteria,and viruses).This enables advancements in disease treatment,biological imaging,biocatalysis,and biosensing.Moreover,genetically engineered biological products can be employed in the construction of biomimetic nanocarriers with tailored functionalities,thereby fostering a virtuous cycle between nanoscience and synthetic biology.This review delves into the applications of NSB within the biomedical field,providing insight into common nanocarriers,nano-bio assembling systems,and specific NSB applications.We hope this review aids researchers in deepening their understanding of the interactions between organisms and nanomaterials,ultimately leading to the development of more innovative biological applications,the advancement of scientific technology,and contributions to addressing significant societal challenges.展开更多
Component commonality has been cited as a powerful approach for manufacturers to cope with increased component proliferation and to control inventory costs. To fully realize its potential benefits, one needs a clear u...Component commonality has been cited as a powerful approach for manufacturers to cope with increased component proliferation and to control inventory costs. To fully realize its potential benefits, one needs a clear understanding of its impacts on the system. In this paper, the feasibility of using a simulation model to provide a systematic perspective for manufacturing firms to implement a commonality strategy is demonstrated. Alternative commonality strategies including the stage of employing commonality and the allocation policies are simulated. Several interesting results on effects of commonality, allocation policies, and optimal solutions are obtained. We then summarize qualitative insights and managerial implications into the component commonality design and implementation, and inventory management in a general multi-stage assembly system.展开更多
文摘Today＇s production systems are demanded to exhibit an increased flexibility and mutability in order to deal with dynamically changing conditions, objectives and an increasing number of product variants within industrial turbulent environments. Flexible automated systems are requested in order to improve dynamic production efficiency, e.g. robot-based hardware and PC-based controllers, but these usually induce a significantly higher production complexity, whereby the efforts for planning and programming, but also setups and reconfiguration, expand. In this paper a definition and some concepts of self-optimizing assembly systems are presented to describe possible ways to reduce the planning efforts in complex production systems. The concept of self-optimization in assembly systems will be derived from a theoretical approach and will be transferred to a specific application scenario---the automated assembly of a miniaturized solid state laser--where the challenges of unpredictable influences from e.g. component tolerances can be overcome by the help of self-optimization.
基金the National Natural Science Foundation of China (Nos. 21272093 and 51473061)the Fundamental Research Funds for the Central Universities (No. JCKY-QKJC05) for financial support
文摘In recent years, cancer has become the number two cause of death around the world, and scientists have exploited various treatment maps. Calixarenes, with diversified features, have been widely applied into drug delivery systems, which can respond to multi-stimuli and exhibit excellent performance. In this mini-review, we summarize the recent advances on controlled drug delivery systems based on calixarenes, in the form of inclusion complexes, amphiphilic self-assembly nanocarriers including micelles, hydrogels, vesicles and liposomes, and supramolecular nanovalves on mesoporous silica nanomaterials.
基金supported by grants from the National Key Re-search&Development Program of China(2021YFA1201000 and 2023YFC2605000)NSFC key project(32030060 and 82430067)+2 种基金NSFC international collaboration key project(51861135103)National Nat-ural Science Foundation of China(32301183,82372104)support by“the Chinese Academy of Sciences(CAS-NSTDA)International Partnership Program”(121D11KYSB20210003).
文摘The rapid advancement of synthetic biology and nanoscience has given rise to a new research field,known as nanoscale synthetic biology(NSB).This field emphasizes the interactions and coordination within entire biological systems,with the goal of achieving more efficient and controllable biological engineering through nanoscale manipulation.Nanocarriers facilitate the delivery of gene-regulating systems(such as CRISPR,mRNA,siRNA,and plasmids),nanozymes,drugs,and specific nanoprobes,enabling precise control over gene expression,modulation of biological metabolism,and monitoring of synthesized products in various organisms(including cells,bacteria,and viruses).This enables advancements in disease treatment,biological imaging,biocatalysis,and biosensing.Moreover,genetically engineered biological products can be employed in the construction of biomimetic nanocarriers with tailored functionalities,thereby fostering a virtuous cycle between nanoscience and synthetic biology.This review delves into the applications of NSB within the biomedical field,providing insight into common nanocarriers,nano-bio assembling systems,and specific NSB applications.We hope this review aids researchers in deepening their understanding of the interactions between organisms and nanomaterials,ultimately leading to the development of more innovative biological applications,the advancement of scientific technology,and contributions to addressing significant societal challenges.
文摘Component commonality has been cited as a powerful approach for manufacturers to cope with increased component proliferation and to control inventory costs. To fully realize its potential benefits, one needs a clear understanding of its impacts on the system. In this paper, the feasibility of using a simulation model to provide a systematic perspective for manufacturing firms to implement a commonality strategy is demonstrated. Alternative commonality strategies including the stage of employing commonality and the allocation policies are simulated. Several interesting results on effects of commonality, allocation policies, and optimal solutions are obtained. We then summarize qualitative insights and managerial implications into the component commonality design and implementation, and inventory management in a general multi-stage assembly system.
