Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promi...Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.展开更多
This paper explores the application effect of humanistic care in the nursing of hemodialysis patients.Firstly,it expounds the application value of humanistic care in the nursing of hemodialysis patients.Then,it evalua...This paper explores the application effect of humanistic care in the nursing of hemodialysis patients.Firstly,it expounds the application value of humanistic care in the nursing of hemodialysis patients.Then,it evaluates the effect by constructing an evaluation index system and combining with empirical analysis.Finally,it puts forward specific application measures and draws conclusions.The purpose is to provide reference for improving the nursing quality of hemodialysis patients,so as to enhance patients’quality of life and promote their physical and mental health.展开更多
Objective:To evaluate the practical application effect of nursing risk management in preventing falls among inpatients,and to provide a reference for optimizing clinical safety management strategies for inpatients.Met...Objective:To evaluate the practical application effect of nursing risk management in preventing falls among inpatients,and to provide a reference for optimizing clinical safety management strategies for inpatients.Methods:A total of 428 inpatients in our hospital from January 2021 to December 2023 were selected as the research objects.They were divided into a control group(218 cases)and a study group(210 cases)according to the nursing management method.The control group received routine fall prevention nursing,while the study group implemented systematic nursing risk management.The fall rate and post-fall injury rate during hospitalization were compared between the two groups.Results:The fall rate of the study group was significantly lower than that of the control group,and the difference was statistically significant(p<0.05).Conclusion:Nursing risk management can effectively reduce the fall rate and post-fall injury rate of inpatients through systematic risk identification,targeted intervention and continuous quality improvement.It also improves patients’awareness of fall prevention and nursing satisfaction,and promotes the improvement of nurses’risk management ability,which has important clinical promotion value.展开更多
Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admit...Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admitted to the hospital from April 2022 to April 2024 were randomly assigned to the intervention group(n=35)and the control group(n=34).The control group received routine community hypertension health management,while the intervention group underwent comprehensive geriatric assessment for comprehensive screening of elderly health issues based on routine management,and implemented targeted nursing interventions based on the characteristics of the chronic disease trajectory.After three months of intervention,the blood pressure,medication compliance,self-efficacy,and quality of life of the two groups were evaluated and analyzed.Results:After the intervention,the intervention group showed significant improvement in blood pressure control,medication compliance,self-management efficacy scores,and quality of life scores compared to the control group(P<0.05).Conclusion:Combining comprehensive geriatric assessment with the concept of chronic disease trajectory nursing in the management of community elderly hypertension can effectively optimize the effect of chronic disease management,which has important practical value.展开更多
Objective:To observe the application effect of risk management in the nursing work of fever clinics,especially its effect on improving nursing satisfaction and the work quality of nursing staff,as well as reducing the...Objective:To observe the application effect of risk management in the nursing work of fever clinics,especially its effect on improving nursing satisfaction and the work quality of nursing staff,as well as reducing the incidence of nursing risk events,and to provide a scientific reference for future clinical research and practice.Methods:This study adopted a retrospective approach,fixing the research period from December 2024 to August 2025.A total of 110 patients admitted to the fever clinic of our hospital were selected as the research objects and divided into two groups(the control group and the experimental group)using the random number table method.Each group had 55 patients.Then,differentiated nursing strategies were implemented for the two groups.Both the control group and the experimental group received routine nursing.The difference was that the experimental group was additionally given risk management measures on the basis of routine nursing.After 7 days of intervention,the nursing satisfaction rate,nursing quality,cognitive score of fever clinic risks,nursing error rate,complaint rate,and incidence of risk events were compared and analyzed between the two groups.Results:The nursing satisfaction score,nursing complaint rate,incidence of nursing risk events,nursing error rate,nursing quality score,and cognitive score of fever clinic risks in the experimental group were significantly better than those in the control group.The differences were statistically significant(P<0.05).Conclusion:Risk management has a significant application effect in the nursing work of fever clinics,playing a positive role for both patients and nursing staff.It is an effective measure to comprehensively improve nursing quality and an important means to greatly reduce the incidence of nursing risk events,thus having high clinical promotion value.展开更多
Objective:This study investigates the effect of orthopedic nursing in patients with ankle fractures.Methods:A total of 84 patients with ankle fractures treated in our hospital from September 2022 to September 2023 wer...Objective:This study investigates the effect of orthopedic nursing in patients with ankle fractures.Methods:A total of 84 patients with ankle fractures treated in our hospital from September 2022 to September 2023 were selected and randomly divided into a control group and an observation group using a random number table,with 42 cases in each group.The control group received routine nursing,while the observation group received orthopedic nursing clinical pathway on the basis of traditional nursing.We analyzed and scored the nursing satisfaction and nursing effect of the two groups.Results:Compared with the control group,the observation group had a higher total nursing satisfaction rate,shorter time to get out of bed,shorter hospital stay,and lower hospitalization cost.The Barid score and AOFAS score of the observation group were higher than those of the control group,while the NRS score was lower.Conclusion:The application of orthopedic nursing clinical pathway in patients with ankle fractures significantly improves their quality of life,promotes better recovery of ankle function,and shortens the rehabilitation time.展开更多
Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to car...Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to carry out this study.They were divided into two groups,the routine group and the observation group,with 191 cases in each group.Newborns in the routine group were given basic nursing intervention,while those in the observation group were given bird’s nest nursing intervention.The growth and development indexes,the occurrence of adverse reactions,the improvement of gastrointestinal function,and the nursing satisfaction rate of their families were analyzed and studied.Results:The growth and development indexes of newborns in the observation group were significantly better than those in the routine group(P<0.05).The incidence of adverse neonatal reactions in the observation group was significantly lower than that in the routine group(P<0.05).The improvement of gastrointestinal function of newborns in the observation group was significantly better than that in the routine group(P<0.05).The nursing satisfaction rate of newborns’families in the observation group was significantly higher than that in the routine group(P<0.05).Conclusion:As for the key points of clinical newborn care,the actual effect of adopting the bird’s nest nursing intervention is more prominent,and its main function is to promote the growth and development of newborns.It can not only avoid the risk of adverse reactions in many aspects but also improve the gastrointestinal function of newborns,so that the nursing satisfaction rate of family members is obviously improved.It is recommended to be applied and popularized in clinical practice.展开更多
The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals...The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals,dielectrics,biological materials,and semiconductors.Because of its unique size effect,nanoscale flexoelectricity has shown novel phenomena and promising applications in electronics,optronics,mechatronics,and photovoltaics.In this review,we provide a succinct report on the discovery and development of the flexoelectric effect,focusing on flexoelectric materials and related applications.Finally,we discuss recent flexoelectric research progress and still‐unsolved problems.展开更多
Effect web will be an important combat means to achieve accurate,efficient,agile and reliable destruction of enemy targets.The use of Unmanned Aerial Vehicles(UAV)cluster in warfare has become a key element in the bat...Effect web will be an important combat means to achieve accurate,efficient,agile and reliable destruction of enemy targets.The use of Unmanned Aerial Vehicles(UAV)cluster in warfare has become a key element in the battle for military superiority between nations.The construction of UAV cluster effect web is a kind of combinatorial optimization in essence.By selecting the optimal combination in the limited equipment concentration,the whole network can be optimized.Firstly,in order to improve the combinatorial optimization efficiency of UAV cluster effect web,NSGA-Ⅱbased on deep Q-network(DQN-based NSGA-Ⅱ)is proposed.This algorithm is used to solve the Multi-Objective Combinatorial Optimization(MOCO)problem in the construction of effect web.Secondly,a dynamic generation method is devised to solve the problem caused by the possible destruction of enemy and our node under the fierce confrontation between the two sides.Finally,the simulation results show that the DQN-based NSGA-Ⅱis better than the genetic algorithm with single operator.The comparison experiment shows that the weight of evaluation indexes will have a corresponding influence on the optimization results.展开更多
Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other...Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.展开更多
In order to gain a deeper understanding of the effect of pulsed current on the mechanical properties and size effect of nanocrystalline Ni foils,nanocrystalline Ni foils with different grain thickness-to-grain size ra...In order to gain a deeper understanding of the effect of pulsed current on the mechanical properties and size effect of nanocrystalline Ni foils,nanocrystalline Ni foils with different grain thickness-to-grain size ratios(λ)were prepared using pulsed electrodeposition in this paper and unidirectional tensile experiments were carried out at room temperature with different currents and their applied directions.The experimental results show that the nanocrystalline Ni foil produces an obvious electroplasticity effect after applying the current field,and when 300<λ<1100,the current weakens the size effect of nanocrystalline Ni foils to a certain extent,and the angle between the current direction and the deformation direction also affects the mechanical response of nanocrystalline Ni foils,and when the angle between the current direction and the deformation direction is 0°,electroplasticity effect is the best,and the current has the most significant effect of abating the size effect of the material.The mechanism of unidirectional tensile deformation of nanocrystalline Ni foils under the effect of pulsed current was analyzed using TEM and TKD.It was found that the applied pulse current increased the activity of the nanocrystalline boundaries,promoted the movement of dislocations,and reduced the tendency of dislocation entanglement.The higher the peak current density and the smaller the angle between the direction of the current and the direction of deformation,the smaller the grain boundary orientation difference,the more dispersed the grain orientation,and the lower the density of geometrically necessary dislocations(GND)in the deformed nanocrystalline foil,the more significant the effect on material plasticity improvement.展开更多
This study aimed to optimize the application rates and base-topdressing ratios of nitrogen and potassium for flue-cured tobacco in Chaling,Zhuzhou,Hunan.The tobacco variety‘Yunyan 87’was planted and subjected to eig...This study aimed to optimize the application rates and base-topdressing ratios of nitrogen and potassium for flue-cured tobacco in Chaling,Zhuzhou,Hunan.The tobacco variety‘Yunyan 87’was planted and subjected to eight different treatments with different application rates and base-topdressing ratios of nitrogen and potassium.The effect of different treatments on the agronomic traits,dry matter accumulation,yield,and quality of tobacco were compared.The results showed that the growth period of each treatment became shortened as the application rates of nitrogen and potassium decreased and as the base-topdressing ratios of nitrogen and potassium increased.The dry matter accumulation decreased with the reduction in the application rates of nitrogen and potassium.The yield and output value of T1 were the highest,reaching 2097.39 kg/hm^(2)and 65018.90 yuan/hm^(2),respectively,both significantly increasing by 57.5%compared with those of the control(CK).In addition,the proportions of leaves of high and mid-high grade in T1 were also the highest,reaching 73.31%and 88.79%,respectively,both higher than those of CK.The appearance evaluation results showed that the appearance quality scores of tobacco leaves of grades B2F and C3F in T1 were the highest,reaching 51 points,both of which were 3 points higher than that those of CK.All the treatments were consistent in terms of color,maturity,leaf structure,body,oil,and color intensity.Therefore,it was suggested that the tobacco production in Chaling should appropriately increase the proportions of nitrogen and potassium as base fertilizers on the basis of conventional fertilization,which was conducive to improving the yield and appearance quality of flue-cured tobacco.展开更多
Patients with cardiovascular disease rely on medication to achieve favorable longterm clinical results.Poor adherence has been linked to a relative increase in mortality of 50%-80%as well as higher health care costs.T...Patients with cardiovascular disease rely on medication to achieve favorable longterm clinical results.Poor adherence has been linked to a relative increase in mortality of 50%-80%as well as higher health care costs.This scoping review thus aimed to explore the evidence of the effects of mobile health care apps on medication adherence in patients with cardiovascular diseases.A comprehensive data search and extraction was done in line with the updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews checklist.A total of 10 studies were included for the review.The mean pooled improvement in adherence was found to be 18%and the most effective tool was the digital therapeutics app discussed in Li et al’s study.Smartphones and apps enhance coronary artery disease management by promoting medication compliance.Challenges include data security and smartphone usage among the elderly.Tailored apps or voice assistants offer potential solutions.展开更多
Objective:To evaluate the application value of lean management in the management of flexible endoscopes.Methods:From January to December 2023,routine management was implemented,and 200 flexible endoscopes used for exa...Objective:To evaluate the application value of lean management in the management of flexible endoscopes.Methods:From January to December 2023,routine management was implemented,and 200 flexible endoscopes used for examination and treatment were included in the control group;from January to December 2024,lean management was implemented,and 200 flexible endoscopes used for examination and treatment were included in the observation group.The average daily usage frequency,management effectiveness,and failure rate of flexible endoscopes were compared between the two groups.Results:The average daily usage frequency of flexible endoscopes in the observation group was higher than that in the control group(P<0.05);the 3S retrieval rate and spot-check qualification rate of endoscopes in the observation group were higher than those in the control group(P<0.05);the failure rate of flexible endoscopes in the observation group was lower than that in the control group(P<0.05).Conclusion:Implementing lean management during the management of flexible endoscopes can improve the efficiency of endoscope retrieval,increase the average daily usage frequency of flexible endoscopes,and reduce endoscope failures.展开更多
[Objectives]To address the weeding challenges within the corn and soybean strip intercropping field and identify appropriate herbicide types and application methods suitable for the corn and soybean strip intercroppin...[Objectives]To address the weeding challenges within the corn and soybean strip intercropping field and identify appropriate herbicide types and application methods suitable for the corn and soybean strip intercropping fields in Siyang County.[Methods]The trial comprised six herbicide treatments and one blank control,with investigations conducted to assess efficacy,safety,and yield.[Results]Each herbicide treatment effectively controlled weeds,demonstrated high safety,and enhanced the yields of both soybeans and corn.The combined application of soil sealing with stem and leaf spray exhibited superior overall weed control compared to soil sealing alone.At 28 d following stem and leaf spray,the plant control effect and fresh weight control effect against weeds in the combined treatment of soil sealing with stem and leaf spray all exceeded 89%.[Conclusions]This study offers technical support for advancing the practice of strip intercropping between corn and soybeans.展开更多
Materials engineering plays a key role in the field of electrochemical energy storage,and considerable efforts have been made in recent years to fulfill the future requirements of electrochemical energy storage using ...Materials engineering plays a key role in the field of electrochemical energy storage,and considerable efforts have been made in recent years to fulfill the future requirements of electrochemical energy storage using novel functional electrode materials.Materials with hollow structures are of particular interests due to their low density,large specific surface area and high porosity,making them promising candidates for energy conversion and storage.The Kirkendall effect has been widely applied for the synthesis of nanoscale hollow structures,which involves an unbalanced counter diffusion through a reaction interface.Herein,the recent progress on the use of the nanoscale Kirkendall effect to synthesize hollow nanostructures,including nanoparticles,one-dimensional(1-D),two-dimensional(2-D),and three-dimensional(3-D)nanostructures,and their potential applications in energy storage devices are summarized and discussed.And prospects is made for the future development of this research field.展开更多
The purpose of this study is to investigate the effectiveness of the“expiration manager”mini program in managing the validity of ward items.The program was used to manage frequently and infrequently used consumables...The purpose of this study is to investigate the effectiveness of the“expiration manager”mini program in managing the validity of ward items.The program was used to manage frequently and infrequently used consumables by setting up an automatic reminder function.The item failure rate and the time required for nurses to conduct counts over 6 months before and after implementation were compared,as well as evaluated system availability using the System Usability scale(SUS).Results showed that after implementing the mini program,both the item failure rate and non-recognition rate significantly decreased(P<0.05),while the inspection pass rate significantly increased(P<0.05),and the monthly inventory time was reduced(P<0.05).The SUS evaluation yielded a total score of 74.38±11.73,with learnability at 80.21±20.27 and availability at 72.92±11.18,all indicating good user acceptance.In conclusion,the“expiration manager”mini program can effectively improve the efficiency of item expiration management,reduce the risk of expiration,and save inspection time,thereby demonstrating high user acceptance and promising potential for wider adoption.展开更多
Inhibiting cadmium(Cd)accumulation in wheat grains could reduce the risk of human exposure to Cd.This study conducted a field experiment and evaluated the effects of iron(Fe)-based biochar and selenium(Se)applications...Inhibiting cadmium(Cd)accumulation in wheat grains could reduce the risk of human exposure to Cd.This study conducted a field experiment and evaluated the effects of iron(Fe)-based biochar and selenium(Se)applications alone or in combination on Cd accumulation in wheat grains in a Cd-contaminated weakly alkaline soil of rice-wheat rotation farmland.Considering soil Cd heterogeneity in the field,we set up 22 replicates of control(CK)and three replicates of each Fe-based biochar and/or Se treatment.Results clearly showed that the CK locations could greatly affect the evaluation of whether the difference in the wheat grain Cd concentration between treatments and CK was significant.There was an insignificant difference in the wheat grain Cd concentration between the treatment and the adjacent CK replicates.Although soil Se application at 2 mg kg^(-1)and foliar Se application at 4 mg L^(-1)significantly increased the grain Se concentration as compared with the adjacent CK replicates,they still could not reduce the Cd concentration in wheat grains.However,when compared to the CK replicates that had the highest grain Cd concentration,foliar and soil applications of Se could significantly reduce the wheat grain Cd concentration by 47.7% and 41.3%-46.1%,respectively.No matter which CK replicates were selected,the application of Fe-based biochar had no significant impact on Cd accumulation in wheat grains,and there was no significant difference in diethylenetriaminepentaacetic acid-Cd concentration between the Fe-based biochar treatment and adjacent CK replicates.In conclusion,applying Fe-based biochar and Se in the field could not reduce the Cd accumulation in wheat grains in Cd-contaminated weakly alkaline soils.展开更多
OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patie...OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patients with osteoporotic vertebral compression fractures treated by vertebroplasty at our hospital were divided into four groups. The control group received non-steroidal anti-inflammatory drugs, the Treatment Group Ⅰ received acupuncture alone, Treatment Group Ⅱ was treated with medicated wine for warming meridians alongside polarized light physiotherapy, and Treatment Group Ⅲ received a combination of medicated wine for warming meridians, polarized light therapy, and acupuncture. The clinical efficacy, pain thresholds at various time points, temperature pain threshold, electric pain threshold, quality of life, sleep quality index, lumbar dysfunction index, visual analog scale(VAS) scores, and incidence of adverse reactions were compared and analyzed across the four groups. RESULTS:The total clinical effective rate in Treatment Group Ⅲ was significantly higher than that in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). At 24 and 72 h post-treatment, the VAS scores, temperature pain thresholds, and electric pain thresholds in Treatment Group Ⅲ were significantly lower than those in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). Additionally, quality-of-life scores in Treatment Group Ⅲ were markedly higher compared to the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ, while the Pittsburgh Sleep Quality Index scores, Oswestry Disability Index scores, and incidence of adverse reactions in Treatment Group Ⅲ were significantly lower than in the other groups(P < 0.05). CONCLUSION:The external application of warm meridian medicated wine and polarized light therapy combined with acupuncture significantly reduces postoperative pain following vertebroplasty, enhances lumbar function, and improves both sleep quality and overall quality of life for patients. This approach is recommended for clinical application.展开更多
Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfil...Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.展开更多
基金Supported by the National Natural Science Foundation of China,No.82072537the General Project of Hunan Natural Science Foundation,No.2022JJ30412 and No.2021JJ30464.
文摘Exosomes(Exos)are extracellular vesicles secreted by cells and serve as crucial mediators of intercellular communication.They play a pivotal role in the pathogenesis and progression of various diseases and offer promising avenues for therapeutic interventions.Exos derived from mesenchymal stem cells(MSCs)have significant immunomodulatory properties.They effectively regulate immune responses by modulating both innate and adaptive immunity.These Exos can inhibit excessive inflammatory responses and promote tissue repair.Moreover,they participate in antigen presentation,which is essential for activating immune responses.The cargo of these Exos,including ligands,proteins,and microRNAs,can suppress T cell activity or enhance the population of immunosuppressive cells to dampen the immune response.By inhibiting lymphocyte proliferation,acting on macrophages,and increasing the population of regulatory T cells,these Exos contribute to maintaining immune and metabolic homeostasis.Furthermore,they can activate immune-related signaling pathways or serve as vehicles to deliver microRNAs and other bioactive substances to target tumor cells,which holds potential for immunotherapy applications.Given the immense therapeutic potential of MSC-derived Exos,this review comprehensively explores their mechanisms of immune regulation and therapeutic applications in areas such as infection control,tumor suppression,and autoimmune disease management.This article aims to provide valuable insights into the mechanisms behind the actions of MSC-derived Exos,offering theoretical references for their future clinical utilization as cell-free drug preparations.
文摘This paper explores the application effect of humanistic care in the nursing of hemodialysis patients.Firstly,it expounds the application value of humanistic care in the nursing of hemodialysis patients.Then,it evaluates the effect by constructing an evaluation index system and combining with empirical analysis.Finally,it puts forward specific application measures and draws conclusions.The purpose is to provide reference for improving the nursing quality of hemodialysis patients,so as to enhance patients’quality of life and promote their physical and mental health.
文摘Objective:To evaluate the practical application effect of nursing risk management in preventing falls among inpatients,and to provide a reference for optimizing clinical safety management strategies for inpatients.Methods:A total of 428 inpatients in our hospital from January 2021 to December 2023 were selected as the research objects.They were divided into a control group(218 cases)and a study group(210 cases)according to the nursing management method.The control group received routine fall prevention nursing,while the study group implemented systematic nursing risk management.The fall rate and post-fall injury rate during hospitalization were compared between the two groups.Results:The fall rate of the study group was significantly lower than that of the control group,and the difference was statistically significant(p<0.05).Conclusion:Nursing risk management can effectively reduce the fall rate and post-fall injury rate of inpatients through systematic risk identification,targeted intervention and continuous quality improvement.It also improves patients’awareness of fall prevention and nursing satisfaction,and promotes the improvement of nurses’risk management ability,which has important clinical promotion value.
基金Nanjing Medical University 2023 Education Research Project(Project No.:2023LX103):Design and Practice of a Primary Care Chronic Disease Management Course Based on the BOPPPS Model-A Case Study of Taizhou RegionTaizhou People’s Hospital Nursing Research Special Project(Project No.:HLYB202411):The Impact of 5A Model-Based Exercise Rehabilitation Guidance on Exercise Adherence in Young and Middle-Aged Hypertensive Patients.
文摘Objective:To study the application effect of comprehensive geriatric assessment tool-oriented chronic disease trajectory nursing in community elderly hypertension.Methods:Sixty nine elderly hypertensive patients admitted to the hospital from April 2022 to April 2024 were randomly assigned to the intervention group(n=35)and the control group(n=34).The control group received routine community hypertension health management,while the intervention group underwent comprehensive geriatric assessment for comprehensive screening of elderly health issues based on routine management,and implemented targeted nursing interventions based on the characteristics of the chronic disease trajectory.After three months of intervention,the blood pressure,medication compliance,self-efficacy,and quality of life of the two groups were evaluated and analyzed.Results:After the intervention,the intervention group showed significant improvement in blood pressure control,medication compliance,self-management efficacy scores,and quality of life scores compared to the control group(P<0.05).Conclusion:Combining comprehensive geriatric assessment with the concept of chronic disease trajectory nursing in the management of community elderly hypertension can effectively optimize the effect of chronic disease management,which has important practical value.
文摘Objective:To observe the application effect of risk management in the nursing work of fever clinics,especially its effect on improving nursing satisfaction and the work quality of nursing staff,as well as reducing the incidence of nursing risk events,and to provide a scientific reference for future clinical research and practice.Methods:This study adopted a retrospective approach,fixing the research period from December 2024 to August 2025.A total of 110 patients admitted to the fever clinic of our hospital were selected as the research objects and divided into two groups(the control group and the experimental group)using the random number table method.Each group had 55 patients.Then,differentiated nursing strategies were implemented for the two groups.Both the control group and the experimental group received routine nursing.The difference was that the experimental group was additionally given risk management measures on the basis of routine nursing.After 7 days of intervention,the nursing satisfaction rate,nursing quality,cognitive score of fever clinic risks,nursing error rate,complaint rate,and incidence of risk events were compared and analyzed between the two groups.Results:The nursing satisfaction score,nursing complaint rate,incidence of nursing risk events,nursing error rate,nursing quality score,and cognitive score of fever clinic risks in the experimental group were significantly better than those in the control group.The differences were statistically significant(P<0.05).Conclusion:Risk management has a significant application effect in the nursing work of fever clinics,playing a positive role for both patients and nursing staff.It is an effective measure to comprehensively improve nursing quality and an important means to greatly reduce the incidence of nursing risk events,thus having high clinical promotion value.
文摘Objective:This study investigates the effect of orthopedic nursing in patients with ankle fractures.Methods:A total of 84 patients with ankle fractures treated in our hospital from September 2022 to September 2023 were selected and randomly divided into a control group and an observation group using a random number table,with 42 cases in each group.The control group received routine nursing,while the observation group received orthopedic nursing clinical pathway on the basis of traditional nursing.We analyzed and scored the nursing satisfaction and nursing effect of the two groups.Results:Compared with the control group,the observation group had a higher total nursing satisfaction rate,shorter time to get out of bed,shorter hospital stay,and lower hospitalization cost.The Barid score and AOFAS score of the observation group were higher than those of the control group,while the NRS score was lower.Conclusion:The application of orthopedic nursing clinical pathway in patients with ankle fractures significantly improves their quality of life,promotes better recovery of ankle function,and shortens the rehabilitation time.
文摘Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to carry out this study.They were divided into two groups,the routine group and the observation group,with 191 cases in each group.Newborns in the routine group were given basic nursing intervention,while those in the observation group were given bird’s nest nursing intervention.The growth and development indexes,the occurrence of adverse reactions,the improvement of gastrointestinal function,and the nursing satisfaction rate of their families were analyzed and studied.Results:The growth and development indexes of newborns in the observation group were significantly better than those in the routine group(P<0.05).The incidence of adverse neonatal reactions in the observation group was significantly lower than that in the routine group(P<0.05).The improvement of gastrointestinal function of newborns in the observation group was significantly better than that in the routine group(P<0.05).The nursing satisfaction rate of newborns’families in the observation group was significantly higher than that in the routine group(P<0.05).Conclusion:As for the key points of clinical newborn care,the actual effect of adopting the bird’s nest nursing intervention is more prominent,and its main function is to promote the growth and development of newborns.It can not only avoid the risk of adverse reactions in many aspects but also improve the gastrointestinal function of newborns,so that the nursing satisfaction rate of family members is obviously improved.It is recommended to be applied and popularized in clinical practice.
基金support of the National Natural Science Foundation of China(Grant Nos.52192611,51872031,61904013,and 62405157)China Postdoctoral Science Foundation(Nos.2023M741890 and GZC20231215)the Fundamental Research Funds for the Central Universities.
文摘The flexoelectric effect refers to the electromechanical coupling between electric polarization and mechanical strain gradient.It universally exists in a variety of materials in any space group,such as liquid crystals,dielectrics,biological materials,and semiconductors.Because of its unique size effect,nanoscale flexoelectricity has shown novel phenomena and promising applications in electronics,optronics,mechatronics,and photovoltaics.In this review,we provide a succinct report on the discovery and development of the flexoelectric effect,focusing on flexoelectric materials and related applications.Finally,we discuss recent flexoelectric research progress and still‐unsolved problems.
基金co-supported by the Fundamental Research Funds for the Central Universities,China。
文摘Effect web will be an important combat means to achieve accurate,efficient,agile and reliable destruction of enemy targets.The use of Unmanned Aerial Vehicles(UAV)cluster in warfare has become a key element in the battle for military superiority between nations.The construction of UAV cluster effect web is a kind of combinatorial optimization in essence.By selecting the optimal combination in the limited equipment concentration,the whole network can be optimized.Firstly,in order to improve the combinatorial optimization efficiency of UAV cluster effect web,NSGA-Ⅱbased on deep Q-network(DQN-based NSGA-Ⅱ)is proposed.This algorithm is used to solve the Multi-Objective Combinatorial Optimization(MOCO)problem in the construction of effect web.Secondly,a dynamic generation method is devised to solve the problem caused by the possible destruction of enemy and our node under the fierce confrontation between the two sides.Finally,the simulation results show that the DQN-based NSGA-Ⅱis better than the genetic algorithm with single operator.The comparison experiment shows that the weight of evaluation indexes will have a corresponding influence on the optimization results.
基金supported by the Key R&D Program of Shandong Province,China(No.2024TZXD067,2022SFGC0105)Natural Science Foundation of Shandong Province(No.ZR2023QB021)+2 种基金Young Taishan Scholarship to Xuekui Xia(No.tsqn202103100)Jinan Talent Project for Universities(No.2021GXRC062,202228088)Key innovation Project and Science,Education and Industry Integration Innovation Pilot Project of Qilu University of Technology(Shandong Academy of Sciences)(No.2022JBZ01-06,2024ZDZX03,2023RCKY214).
文摘Jing Fang granules(JFG)are a modern Chinese medicinal formulation derived from Jing Fang Defeating Toxin San(JFDS).JFG primarily contains bioactive compounds such as flavonoids/flavonoid glycosides,coumarins and other components,which have various activities:anti-inflammatory,immune system regulation,antiviral,anti-aging,detoxification,and protection of the liver,lungs,and kidneys.JFG has broad potential therapeutic applications.The mechanisms of JFG’s actions are primarily associated with signaling pathways such as TLR4/NF-κB,PI3K/AKT,and MAPK.This article reviews the research progress on JFG,including chemical composition,pharmacologic effects,mechanism of action,safety,clinical application,etc.,serving as a foundation for future research and clinical applications.
基金Project(51975167)supported by the National Natural Science Foundation of China。
文摘In order to gain a deeper understanding of the effect of pulsed current on the mechanical properties and size effect of nanocrystalline Ni foils,nanocrystalline Ni foils with different grain thickness-to-grain size ratios(λ)were prepared using pulsed electrodeposition in this paper and unidirectional tensile experiments were carried out at room temperature with different currents and their applied directions.The experimental results show that the nanocrystalline Ni foil produces an obvious electroplasticity effect after applying the current field,and when 300<λ<1100,the current weakens the size effect of nanocrystalline Ni foils to a certain extent,and the angle between the current direction and the deformation direction also affects the mechanical response of nanocrystalline Ni foils,and when the angle between the current direction and the deformation direction is 0°,electroplasticity effect is the best,and the current has the most significant effect of abating the size effect of the material.The mechanism of unidirectional tensile deformation of nanocrystalline Ni foils under the effect of pulsed current was analyzed using TEM and TKD.It was found that the applied pulse current increased the activity of the nanocrystalline boundaries,promoted the movement of dislocations,and reduced the tendency of dislocation entanglement.The higher the peak current density and the smaller the angle between the direction of the current and the direction of deformation,the smaller the grain boundary orientation difference,the more dispersed the grain orientation,and the lower the density of geometrically necessary dislocations(GND)in the deformed nanocrystalline foil,the more significant the effect on material plasticity improvement.
文摘This study aimed to optimize the application rates and base-topdressing ratios of nitrogen and potassium for flue-cured tobacco in Chaling,Zhuzhou,Hunan.The tobacco variety‘Yunyan 87’was planted and subjected to eight different treatments with different application rates and base-topdressing ratios of nitrogen and potassium.The effect of different treatments on the agronomic traits,dry matter accumulation,yield,and quality of tobacco were compared.The results showed that the growth period of each treatment became shortened as the application rates of nitrogen and potassium decreased and as the base-topdressing ratios of nitrogen and potassium increased.The dry matter accumulation decreased with the reduction in the application rates of nitrogen and potassium.The yield and output value of T1 were the highest,reaching 2097.39 kg/hm^(2)and 65018.90 yuan/hm^(2),respectively,both significantly increasing by 57.5%compared with those of the control(CK).In addition,the proportions of leaves of high and mid-high grade in T1 were also the highest,reaching 73.31%and 88.79%,respectively,both higher than those of CK.The appearance evaluation results showed that the appearance quality scores of tobacco leaves of grades B2F and C3F in T1 were the highest,reaching 51 points,both of which were 3 points higher than that those of CK.All the treatments were consistent in terms of color,maturity,leaf structure,body,oil,and color intensity.Therefore,it was suggested that the tobacco production in Chaling should appropriately increase the proportions of nitrogen and potassium as base fertilizers on the basis of conventional fertilization,which was conducive to improving the yield and appearance quality of flue-cured tobacco.
文摘Patients with cardiovascular disease rely on medication to achieve favorable longterm clinical results.Poor adherence has been linked to a relative increase in mortality of 50%-80%as well as higher health care costs.This scoping review thus aimed to explore the evidence of the effects of mobile health care apps on medication adherence in patients with cardiovascular diseases.A comprehensive data search and extraction was done in line with the updated Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews checklist.A total of 10 studies were included for the review.The mean pooled improvement in adherence was found to be 18%and the most effective tool was the digital therapeutics app discussed in Li et al’s study.Smartphones and apps enhance coronary artery disease management by promoting medication compliance.Challenges include data security and smartphone usage among the elderly.Tailored apps or voice assistants offer potential solutions.
文摘Objective:To evaluate the application value of lean management in the management of flexible endoscopes.Methods:From January to December 2023,routine management was implemented,and 200 flexible endoscopes used for examination and treatment were included in the control group;from January to December 2024,lean management was implemented,and 200 flexible endoscopes used for examination and treatment were included in the observation group.The average daily usage frequency,management effectiveness,and failure rate of flexible endoscopes were compared between the two groups.Results:The average daily usage frequency of flexible endoscopes in the observation group was higher than that in the control group(P<0.05);the 3S retrieval rate and spot-check qualification rate of endoscopes in the observation group were higher than those in the control group(P<0.05);the failure rate of flexible endoscopes in the observation group was lower than that in the control group(P<0.05).Conclusion:Implementing lean management during the management of flexible endoscopes can improve the efficiency of endoscope retrieval,increase the average daily usage frequency of flexible endoscopes,and reduce endoscope failures.
文摘[Objectives]To address the weeding challenges within the corn and soybean strip intercropping field and identify appropriate herbicide types and application methods suitable for the corn and soybean strip intercropping fields in Siyang County.[Methods]The trial comprised six herbicide treatments and one blank control,with investigations conducted to assess efficacy,safety,and yield.[Results]Each herbicide treatment effectively controlled weeds,demonstrated high safety,and enhanced the yields of both soybeans and corn.The combined application of soil sealing with stem and leaf spray exhibited superior overall weed control compared to soil sealing alone.At 28 d following stem and leaf spray,the plant control effect and fresh weight control effect against weeds in the combined treatment of soil sealing with stem and leaf spray all exceeded 89%.[Conclusions]This study offers technical support for advancing the practice of strip intercropping between corn and soybeans.
文摘Materials engineering plays a key role in the field of electrochemical energy storage,and considerable efforts have been made in recent years to fulfill the future requirements of electrochemical energy storage using novel functional electrode materials.Materials with hollow structures are of particular interests due to their low density,large specific surface area and high porosity,making them promising candidates for energy conversion and storage.The Kirkendall effect has been widely applied for the synthesis of nanoscale hollow structures,which involves an unbalanced counter diffusion through a reaction interface.Herein,the recent progress on the use of the nanoscale Kirkendall effect to synthesize hollow nanostructures,including nanoparticles,one-dimensional(1-D),two-dimensional(2-D),and three-dimensional(3-D)nanostructures,and their potential applications in energy storage devices are summarized and discussed.And prospects is made for the future development of this research field.
基金The First Affiliated Hospital of Shaoyang University,China(Project No.:23FY1015)。
文摘The purpose of this study is to investigate the effectiveness of the“expiration manager”mini program in managing the validity of ward items.The program was used to manage frequently and infrequently used consumables by setting up an automatic reminder function.The item failure rate and the time required for nurses to conduct counts over 6 months before and after implementation were compared,as well as evaluated system availability using the System Usability scale(SUS).Results showed that after implementing the mini program,both the item failure rate and non-recognition rate significantly decreased(P<0.05),while the inspection pass rate significantly increased(P<0.05),and the monthly inventory time was reduced(P<0.05).The SUS evaluation yielded a total score of 74.38±11.73,with learnability at 80.21±20.27 and availability at 72.92±11.18,all indicating good user acceptance.In conclusion,the“expiration manager”mini program can effectively improve the efficiency of item expiration management,reduce the risk of expiration,and save inspection time,thereby demonstrating high user acceptance and promising potential for wider adoption.
基金financially supported by the National Natural Science Foundation of China(No.42107005)the Research and Development Fund of Zhejiang A&F University,China(No.2024LFR027)+1 种基金the Jiangsu Provincial Key Research and Development Program,China(No.BE2021717)the Agricultural Independent Innovation Fund of Jiangsu Province,China(No.CX(24)1001)。
文摘Inhibiting cadmium(Cd)accumulation in wheat grains could reduce the risk of human exposure to Cd.This study conducted a field experiment and evaluated the effects of iron(Fe)-based biochar and selenium(Se)applications alone or in combination on Cd accumulation in wheat grains in a Cd-contaminated weakly alkaline soil of rice-wheat rotation farmland.Considering soil Cd heterogeneity in the field,we set up 22 replicates of control(CK)and three replicates of each Fe-based biochar and/or Se treatment.Results clearly showed that the CK locations could greatly affect the evaluation of whether the difference in the wheat grain Cd concentration between treatments and CK was significant.There was an insignificant difference in the wheat grain Cd concentration between the treatment and the adjacent CK replicates.Although soil Se application at 2 mg kg^(-1)and foliar Se application at 4 mg L^(-1)significantly increased the grain Se concentration as compared with the adjacent CK replicates,they still could not reduce the Cd concentration in wheat grains.However,when compared to the CK replicates that had the highest grain Cd concentration,foliar and soil applications of Se could significantly reduce the wheat grain Cd concentration by 47.7% and 41.3%-46.1%,respectively.No matter which CK replicates were selected,the application of Fe-based biochar had no significant impact on Cd accumulation in wheat grains,and there was no significant difference in diethylenetriaminepentaacetic acid-Cd concentration between the Fe-based biochar treatment and adjacent CK replicates.In conclusion,applying Fe-based biochar and Se in the field could not reduce the Cd accumulation in wheat grains in Cd-contaminated weakly alkaline soils.
文摘OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patients with osteoporotic vertebral compression fractures treated by vertebroplasty at our hospital were divided into four groups. The control group received non-steroidal anti-inflammatory drugs, the Treatment Group Ⅰ received acupuncture alone, Treatment Group Ⅱ was treated with medicated wine for warming meridians alongside polarized light physiotherapy, and Treatment Group Ⅲ received a combination of medicated wine for warming meridians, polarized light therapy, and acupuncture. The clinical efficacy, pain thresholds at various time points, temperature pain threshold, electric pain threshold, quality of life, sleep quality index, lumbar dysfunction index, visual analog scale(VAS) scores, and incidence of adverse reactions were compared and analyzed across the four groups. RESULTS:The total clinical effective rate in Treatment Group Ⅲ was significantly higher than that in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). At 24 and 72 h post-treatment, the VAS scores, temperature pain thresholds, and electric pain thresholds in Treatment Group Ⅲ were significantly lower than those in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). Additionally, quality-of-life scores in Treatment Group Ⅲ were markedly higher compared to the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ, while the Pittsburgh Sleep Quality Index scores, Oswestry Disability Index scores, and incidence of adverse reactions in Treatment Group Ⅲ were significantly lower than in the other groups(P < 0.05). CONCLUSION:The external application of warm meridian medicated wine and polarized light therapy combined with acupuncture significantly reduces postoperative pain following vertebroplasty, enhances lumbar function, and improves both sleep quality and overall quality of life for patients. This approach is recommended for clinical application.
基金Supported by National Key Research and Development Program of China(No.2023YFC3707901)。
文摘Evaluation of backfilling effectiveness plays a crucial role in the geological environment management and restoration of abandoned open-pit quarries,providing a scientific basis for subsequent greening efforts.Backfill soil,predominantly composed of silty clay,demonstrates high water retention capacity and elevated moisture content,leading to a pronounced resistivity contrast with the bedrock exposed by quarrying activities.To investigate the distribution of backfill soil subsurface and assess backfilling effectiveness in the study area,this study conducted a comprehensive geophysical investigation utilizing the high-density electrical resistivity tomography(ERT).A total of 19 ERT survey lines were deployed across three distinct areas in Liuyao Village,Huaibei City,Anhui Province,China.The inversion results,derived from both two-dimensional(2D)and three-dimensional(3D),reveal distinct electrical properties of the subsurface materials:the backfill soil layer shows low resistivity features,the fill stone layer exhibits medium to high resistivity,and the bedrock shows the highest resistivity.The 2D inversion results,from the data measured using the Wenner array effectively capture the spatial distribution and structural features of the backfill soil layer.The findings indicate a gradual east-west thinning of the clay layer within the quarry.Furthermore,the northern pit area exhibits a uniform distribution of backfill soil layer,indicative of effective backfilling operations.In contrast,the southern pit area lacks a well-defined clay layer,suggesting suboptimal backfilling effectiveness.
