The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve ...The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the NIF.Here,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2-3 PW at 3ω(or 2ω,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>30.It is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.展开更多
Asymmetric catalysis has been one of the most effective strategies for building up a chirality in the favored stereoisomer. Over the past decades, various sophisticated chiral ligands and catalysts have been well-desi...Asymmetric catalysis has been one of the most effective strategies for building up a chirality in the favored stereoisomer. Over the past decades, various sophisticated chiral ligands and catalysts have been well-designed, which enable great advances in enantioselective chemical transformations, for achieving excellent selectivity and activity.展开更多
Aqueous supercapacitors(SCs)have been regarded as a promising candidate for commercial energy storage device due to their superior safety,low cost,and environmental benignity.Unfortunately,an age-old challenge of achi...Aqueous supercapacitors(SCs)have been regarded as a promising candidate for commercial energy storage device due to their superior safety,low cost,and environmental benignity.Unfortunately,an age-old challenge of achieving both long electrode lifespan and qualified energy-storage property blocks their practical application.Herein,we develop an electrode-electrolyte integrated optimization strategy to fulfill the real-life device requirements.Electrode optimization simultaneously regulates the nanomorphology and surface chemistry of the tungsten oxide anode,resulting in superior electrochemical performance given by an ideal“bird-nest”structure with optimal oxygen vacancy status;the anodes interact with and are protected from dissolution and structural collapse by the rationally designed hybrid electrolyte with optimized pH and facilitated cation desorption behavior.Collaboratively,a record-breaking durability of no capacitive decay after 250000 cycles is achieved.On the basis of this integrated optimization,the first aqueous pouch SCs with real-life practicability were manufactured by a soft-package encapsulation technique,which can steadily power commercial 3 C products such as tablets and smartphones and maintain safely working against extreme conditions.This work demonstrates the possibility of using aqueous energy storage devices with enhanced safety and lower cost to replace the commercial organic counterparts for wide range of daily applications.展开更多
The ETSI Technical Committee on Cybersecurity (TC CYBER) has just released ETSI TS 103645, a standard for cybersecurity in the Internet of Things, to establish a security baseline for internet-connected consumer produ...The ETSI Technical Committee on Cybersecurity (TC CYBER) has just released ETSI TS 103645, a standard for cybersecurity in the Internet of Things, to establish a security baseline for internet-connected consumer products and provide a basis for future IoT certification schemes.展开更多
Directly Applicable Law is an important achievement theory of private international law in the late nineteen fifties, widely used by states. The people＇ s Republic of China foreign civil legal relationship applicable...Directly Applicable Law is an important achievement theory of private international law in the late nineteen fifties, widely used by states. The people＇ s Republic of China foreign civil legal relationship applicable law established the frame of our country＇ s Directly Applicable Law in the legislative level. In practice, there exists some shortcomings in the use of the rules and theory of Directly Applicable Law. In this paper, the author defines the rules from the micro level to order picture from macro level as the starting point, discussed the perfect approach of Directly Applicable Law from the dimension of the interpretation, system, evolution route ,and rethought our current legislative situation.展开更多
There are so many different opinions on whether the autonomy of will is applied in labor contract.In this paper,the author discusses the application and limitation of autonomy of will in labor contract,and puts forwar...There are so many different opinions on whether the autonomy of will is applied in labor contract.In this paper,the author discusses the application and limitation of autonomy of will in labor contract,and puts forward some suggestions on the application of Article 43 of Law of the Application of Law for Foreign-related Civil Relationships after the introduction of Chinese legislation of the applicable law of labor contract.Autonomy of will is a useful principle in resolving disputes arising from foreign-related labor contract in China.展开更多
Based on the applicable principle of liquidated damages in ＂contract law＂, based on the improvement of the system, the article first analyzes the status quo of the development of the default system and secondly puts...Based on the applicable principle of liquidated damages in ＂contract law＂, based on the improvement of the system, the article first analyzes the status quo of the development of the default system and secondly puts forward some suggestions for improvement. The final purpose is to perfect the liquidated damages system with the Contract Law, in a bid to enhance the fairness of liquidated damages.展开更多
In order to quickly and accurately evaluate gas well deliverability,it is necessary to clarify the applicable conditions of the simplified laminarinertial-turbulent gas well deliverability evaluation method(i.e.,press...In order to quickly and accurately evaluate gas well deliverability,it is necessary to clarify the applicable conditions of the simplified laminarinertial-turbulent gas well deliverability evaluation method(i.e.,pressure-squared method and pressure method).In this regard,this paper analyzes the PVT data,simulation wells and field case wells of typical gas reservoirs in China by reviewing the formal evolution of the flow control equation for the real gases in porous media.Then,the applicable conditions of binomial pressure-squared method and pressure method are discussed.And the following research results were obtained.First,when the pressure is lower than 14 MPa,p/(μZ) is basically a constant;and when the pressure is higher than 42 MPa,μZ is basically a constant.Second,the applicable range of the pressure-squared method can be increased from 14 to 20 MPa.In this case,the relative error of absolute open flow potential calculated using the pressure-squared method is less than 5%compared with the pseudo-pressure method.If the pressure is between 20 and 30 MPa,the relative error of the absolute open flow potential calculated using the pressure-squared method is less than 10%.Third,when the pressure exceeds 80 MPa,the relative error of the absolute open flow potential calculated using the pressure method is less than 10%compared with the pseudo-pressure method.If the pressure-squared method is used in the case of high pressure,the calculated absolute open flow potential is lower and the relative error is close to 25%.Fourth,in the case of low pressure,if the pressure is constant,the higher the temperature is,the smaller the relative error between the pressure-squared method and the pseudo-pressure method is.In the case of high pressure,if the pressure is constant,the higher the temperature is,the greater the relative error between the pressure method and the pseudo-pressure method.In conclusion,it is recommended to adopt the pseudo-pressure method in laminareinertial-turbulent gas well deliverability analysis.In the case of low pressure(below 30 MPa),the pressure-squared method can be used.In the case of high pressure(above 80 MPa),the pressure method can be applied.展开更多
The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis(ARN).The potential application of artificial intelligence(AI)alg...The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis(ARN).The potential application of artificial intelligence(AI)algorithms in these areas of clinical research has not been reported previously.The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs.A total of 149 wide-angle fundus photographs from40 eyes of 32 ARN patients were collected,and the U-Net method was used to construct the AI algorithm.Thereby,a novel algorithm based on deep machine learning in detection and evaluation of retinal necrosis was constructed for the first time.This algorithm had an area under the receiver operating curve of 0.92,with 86%sensitivity and 88%specificity in the detection of retinal necrosis.For the purpose of retinal necrosis evaluation,necrotic areas calculated by the AI algorithm were significantly positively correlated with viral load in aqueous humor samples(R2=0.7444,P<0.0001)and therapeutic response of ARN(R2=0.999,P<0.0001).Therefore,our AI algorithm has a potential application in the clinical aided diagnosis of ARN,evaluation of ARN severity,and treatment response monitoring.展开更多
In this work, by choosing an orthonormal basis for the Hilbert space L^2[0, 1], an approximation method for finding approximate solutions of the equation （I ＋ K）x = y is proposed, called Haar wavelet approximation ...In this work, by choosing an orthonormal basis for the Hilbert space L^2[0, 1], an approximation method for finding approximate solutions of the equation （I ＋ K）x = y is proposed, called Haar wavelet approximation method （HWAM）. To prove the applicabifity of the HWAM, a more general applicability theorem on an approximation method （AM） for an operator equation Ax = y is proved first. As an application, applicability of the HWAM is obtained. Fhrthermore, four steps to use the HWAM are listed and three numerical examples are given in order to illustrate the effectiveness of the method.展开更多
Actively pushing design knowledge to designers in the design process, what we call ‘knowledge push＇, can help improve the efficiency and quality of intelligent product design. A knowledge push technology usually inc...Actively pushing design knowledge to designers in the design process, what we call ‘knowledge push＇, can help improve the efficiency and quality of intelligent product design. A knowledge push technology usually includes matching of related knowledge and proper pushing of matching results. Existing approaches on knowledge matching commonly have a lack of intelligence. Also, the pushing of matching results is less personalized. In this paper, we propose a knowledge push technology based on applicable probability matching and multidimensional context driving. By building a training sample set, including knowledge description vectors, case feature vectors, and the mapping Boolean matrix, two probability values, application and non-application, were calculated via a Bayesian theorem to describe the matching degree between knowledge and content. The push results were defined by the comparison between two probability values. The hierarchical design content models were built to filter the knowledge in push results. The rules of personalized knowledge push were sorted by multidimensional contexts, which include design knowledge, design context, design content, and the designer. A knowledge push system based on intellectualized design of CNC machine tools was used to confirm the feasibility of the proposed technology in engineering applications.展开更多
China has entered a new era represented by the newly established China （Shanghai） Pilot Free Trade Zone, in which further reform and development of its financial system and capital market are highly prioritized. The...China has entered a new era represented by the newly established China （Shanghai） Pilot Free Trade Zone, in which further reform and development of its financial system and capital market are highly prioritized. The trust as an important vehicle in development of the financial market in China as well as in the world will play an important role, and there will be more foreign elements involved in Chinese trusts. The Law of the People＇s Republic of China on Application of Laws in Civil Relations with Foreign Elements provides rules, in its article 17, on the application of laws to trusts, which symbolizes the formal creation of rules of conflict of laws in China in this area. However, it seems to cause more problems than it may resolve. For example, it may not always be possible for the parties to determine the appli- cable law through consultation and agreement, and the parties＇ right to choice of law should not be without limitation either. By allowing judges to choose from ＂the law of the situs where the trust property is situated＂ and ＂the law of the situs where the trust relationship occurred＂ in the absence of an effective choice of law by the parties may lead to a situation contrary to existing laws and may create uncertainty for the parties as well. This paper analyzes this article 17 by comparing it with the conflict law rules adopted in the United States and by the Hague Convention, identifies problems, and seeks to find solutions in order to promote the healthy development of the trust system in China.展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays...As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays a pivotal role in MEC performance but remains challenging due to complex task topologies,conflicting objectives,and limited resources.This paper addresses high-dimensional multi-objective offloading for serial heterogeneous tasks in MEC.We jointly consider task heterogeneity,high-dimensional objectives,and flexible resource scheduling,modeling the problem as a Many-objective optimization.To solve it,we propose a flexible framework integrating an improved cooperative co-evolutionary algorithm based on decomposition(MOCC/D)and a flexible scheduling strategy.Experimental results on benchmark functions and simulation scenarios show that the proposed method outperforms existing approaches in both convergence and solution quality.展开更多
The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multi...The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multiple sclerosis,neuromyelitis optica spectrum disorder,myasthenia gravis,Guillain–Barre syndrome,acute disseminated encephalomyelitis,diabetes,inflammatory skin diseases,joint inflammation,and cancer.Although the function of the interleukin-17 family has attracted increasing research attention over many years,the expression,function,and regulation mechanisms of different interleukin-17 members are complicated and still only partially understood.Currently,the interleukin-17A pathway is considered a critical therapeutic target for numerous immune and chronic inflammatory diseases,with several monoclonal antibodies against interleukin-17A having been successfully used in clinical practice.Whether other interleukin-17 members have the potential to be targeted in other diseases is still debated.This review first summarizes the recent advancements in understanding the physicochemical properties,physiological functions,cellular origins,and downstream signaling pathways of different members and corresponding receptors of the interleukin-17 family.Subsequently,the function of interleukin-17 in various immune diseases is discussed,and the important role of interleukin-17 in the pathological process of immune diseases is demonstrated from multiple perspectives.Then,the current status of targeted interleukin-17 therapy is summarized,and the effectiveness and safety of targeted interleukin-17 therapy are analyzed.Finally,the clinical application prospects of targeting the interleukin-17 pathway are discussed.展开更多
In this paper, it is studied that the scattering effect is caused by microphones itself, on both wave magnitude and phase. The experimental method was found difficult to do this. We will apply the Boundary Element Met...In this paper, it is studied that the scattering effect is caused by microphones itself, on both wave magnitude and phase. The experimental method was found difficult to do this. We will apply the Boundary Element Method(BEM) to the problem and explain the results obtained. The numerical method seems to be a powerful tool in this situation.展开更多
Once considered conventional,the construction industry is gradually increasing its reliance on innovations such as the application of technologies in safety management.Given the growing literature on technology applic...Once considered conventional,the construction industry is gradually increasing its reliance on innovations such as the application of technologies in safety management.Given the growing literature on technology applications in safety management and the varying opinions on the utility of applied technologies,a systematic review that streamlines findings from past studies is indispensable to construction stakeholders.Although a number of review studies are available in the building construction sector,the level of fragmentation and uniqueness within the construction industry necessitates a review study specifically targeting the heavy civil sector.In response,the present study applies a three-step approach to identify and review articles pertinent to the safety of highway construction work zones.The factors considered include the number of publications per year,publication locations,and technology types.In addition,the present study proposes to broadly group work zone safety technologies(WZSTs)into three categories based on their primary purpose:speed reduction systems,intrusion prevention and warning systems,and human-machine-interaction detection systems.Key findings include WZST research trends,application of smart work zone systems,and the potential relationship between WZSTs and fatalities.The paper ends with the identification of six additional research areas aimed at deepening the understanding of technology’s role in highway safety management.The trend analysis and an in-depth discussion of each technology category alongside the identified research gaps will provide a substantial informative body of knowledge that both benefits current practitioners and directs researchers towards potential future studies.展开更多
α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organi...α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organic compounds with diverse structures.Herein,the advances in the research areas ofα-trifluoromethyl ketone synthesis and their defluorination reactions are reviewed.Discussion on the mechanisms of the typical reactions has also been provided,in hope of affording some guides to the chemistry ofα-trifluoromethyl ketones in the synthetic methods toward themselves and their derivatives.展开更多
Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vi...Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12035002).
文摘The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the NIF.Here,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2-3 PW at 3ω(or 2ω,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>30.It is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.
文摘Asymmetric catalysis has been one of the most effective strategies for building up a chirality in the favored stereoisomer. Over the past decades, various sophisticated chiral ligands and catalysts have been well-designed, which enable great advances in enantioselective chemical transformations, for achieving excellent selectivity and activity.
基金supported by the National Natural Science Foundation of China(Nos.52071171,52202248 and 22209064)Liaoning Revitalization Talents Program—Pan Deng Scholars(XLYC1802005)+9 种基金Liaoning Bai Qian Wan Talents Program(LNBQW2018B0048)Key Project of Scientific Research of the Education Department of Liaoning Province(LZD201902)Shenyang Science and Technology Project(21-108-9-04)Australian Research Council(ARC)through Future Fel owship(FT210100298,FT210100806)Discovery Project(DP220100603)Linkage Project(LP210100467,LP210200504,and LP210200345)Industrial Transformation Training Centre(IC180100005)schemes,CSIRO Energy Centre and Kick-Start ProjectStudy Melbourne Research Partnerships program has been made possible by funding from the Victorian Government through Study MelbourneShiyanjia Lab(www.shiyanjia.com)for the support of the XPS testsupport from the University of Calgary’s Canada First Research Excel ence Fund program,the Global Research Initiative for Sustainable Low-Carbon Unconventional Energy
文摘Aqueous supercapacitors(SCs)have been regarded as a promising candidate for commercial energy storage device due to their superior safety,low cost,and environmental benignity.Unfortunately,an age-old challenge of achieving both long electrode lifespan and qualified energy-storage property blocks their practical application.Herein,we develop an electrode-electrolyte integrated optimization strategy to fulfill the real-life device requirements.Electrode optimization simultaneously regulates the nanomorphology and surface chemistry of the tungsten oxide anode,resulting in superior electrochemical performance given by an ideal“bird-nest”structure with optimal oxygen vacancy status;the anodes interact with and are protected from dissolution and structural collapse by the rationally designed hybrid electrolyte with optimized pH and facilitated cation desorption behavior.Collaboratively,a record-breaking durability of no capacitive decay after 250000 cycles is achieved.On the basis of this integrated optimization,the first aqueous pouch SCs with real-life practicability were manufactured by a soft-package encapsulation technique,which can steadily power commercial 3 C products such as tablets and smartphones and maintain safely working against extreme conditions.This work demonstrates the possibility of using aqueous energy storage devices with enhanced safety and lower cost to replace the commercial organic counterparts for wide range of daily applications.
文摘The ETSI Technical Committee on Cybersecurity (TC CYBER) has just released ETSI TS 103645, a standard for cybersecurity in the Internet of Things, to establish a security baseline for internet-connected consumer products and provide a basis for future IoT certification schemes.
文摘Directly Applicable Law is an important achievement theory of private international law in the late nineteen fifties, widely used by states. The people＇ s Republic of China foreign civil legal relationship applicable law established the frame of our country＇ s Directly Applicable Law in the legislative level. In practice, there exists some shortcomings in the use of the rules and theory of Directly Applicable Law. In this paper, the author defines the rules from the micro level to order picture from macro level as the starting point, discussed the perfect approach of Directly Applicable Law from the dimension of the interpretation, system, evolution route ,and rethought our current legislative situation.
文摘There are so many different opinions on whether the autonomy of will is applied in labor contract.In this paper,the author discusses the application and limitation of autonomy of will in labor contract,and puts forward some suggestions on the application of Article 43 of Law of the Application of Law for Foreign-related Civil Relationships after the introduction of Chinese legislation of the applicable law of labor contract.Autonomy of will is a useful principle in resolving disputes arising from foreign-related labor contract in China.
文摘Based on the applicable principle of liquidated damages in ＂contract law＂, based on the improvement of the system, the article first analyzes the status quo of the development of the default system and secondly puts forward some suggestions for improvement. The final purpose is to perfect the liquidated damages system with the Contract Law, in a bid to enhance the fairness of liquidated damages.
基金Project supported by Major Science&Technology Project of PetroChina Company Limited“Research and application of key technologies for development of deepeultra-deep gas reservoirs in Kuqa Depression”(No.:2018E-1803).
文摘In order to quickly and accurately evaluate gas well deliverability,it is necessary to clarify the applicable conditions of the simplified laminarinertial-turbulent gas well deliverability evaluation method(i.e.,pressure-squared method and pressure method).In this regard,this paper analyzes the PVT data,simulation wells and field case wells of typical gas reservoirs in China by reviewing the formal evolution of the flow control equation for the real gases in porous media.Then,the applicable conditions of binomial pressure-squared method and pressure method are discussed.And the following research results were obtained.First,when the pressure is lower than 14 MPa,p/(μZ) is basically a constant;and when the pressure is higher than 42 MPa,μZ is basically a constant.Second,the applicable range of the pressure-squared method can be increased from 14 to 20 MPa.In this case,the relative error of absolute open flow potential calculated using the pressure-squared method is less than 5%compared with the pseudo-pressure method.If the pressure is between 20 and 30 MPa,the relative error of the absolute open flow potential calculated using the pressure-squared method is less than 10%.Third,when the pressure exceeds 80 MPa,the relative error of the absolute open flow potential calculated using the pressure method is less than 10%compared with the pseudo-pressure method.If the pressure-squared method is used in the case of high pressure,the calculated absolute open flow potential is lower and the relative error is close to 25%.Fourth,in the case of low pressure,if the pressure is constant,the higher the temperature is,the smaller the relative error between the pressure-squared method and the pseudo-pressure method is.In the case of high pressure,if the pressure is constant,the higher the temperature is,the greater the relative error between the pressure method and the pseudo-pressure method.In conclusion,it is recommended to adopt the pseudo-pressure method in laminareinertial-turbulent gas well deliverability analysis.In the case of low pressure(below 30 MPa),the pressure-squared method can be used.In the case of high pressure(above 80 MPa),the pressure method can be applied.
基金the National Natural Science Foundation of China(Nos.81870648 and 82070949)。
文摘The prompt detection and proper evaluation of necrotic retinal region are especially important for the diagnosis and treatment of acute retinal necrosis(ARN).The potential application of artificial intelligence(AI)algorithms in these areas of clinical research has not been reported previously.The present study aims to create a computational algorithm for the automated detection and evaluation of retinal necrosis from retinal fundus photographs.A total of 149 wide-angle fundus photographs from40 eyes of 32 ARN patients were collected,and the U-Net method was used to construct the AI algorithm.Thereby,a novel algorithm based on deep machine learning in detection and evaluation of retinal necrosis was constructed for the first time.This algorithm had an area under the receiver operating curve of 0.92,with 86%sensitivity and 88%specificity in the detection of retinal necrosis.For the purpose of retinal necrosis evaluation,necrotic areas calculated by the AI algorithm were significantly positively correlated with viral load in aqueous humor samples(R2=0.7444,P<0.0001)and therapeutic response of ARN(R2=0.999,P<0.0001).Therefore,our AI algorithm has a potential application in the clinical aided diagnosis of ARN,evaluation of ARN severity,and treatment response monitoring.
基金support by the NSFC(11371012,11401359,11471200)the FRF for the Central Universities(GK201301007)the NSRP of Shaanxi Province(2014JQ1010)
文摘In this work, by choosing an orthonormal basis for the Hilbert space L^2[0, 1], an approximation method for finding approximate solutions of the equation （I ＋ K）x = y is proposed, called Haar wavelet approximation method （HWAM）. To prove the applicabifity of the HWAM, a more general applicability theorem on an approximation method （AM） for an operator equation Ax = y is proved first. As an application, applicability of the HWAM is obtained. Fhrthermore, four steps to use the HWAM are listed and three numerical examples are given in order to illustrate the effectiveness of the method.
基金Project supported by the National Natural Science Foundation of China(No.51675478)the Natural Science Foundation of Zhejiang Province,China(No.LY15E050004)Youth Funds of the State Key Laboratory of Fluid Power&Mechatronic Systems,Zhejiang University
文摘Actively pushing design knowledge to designers in the design process, what we call ‘knowledge push＇, can help improve the efficiency and quality of intelligent product design. A knowledge push technology usually includes matching of related knowledge and proper pushing of matching results. Existing approaches on knowledge matching commonly have a lack of intelligence. Also, the pushing of matching results is less personalized. In this paper, we propose a knowledge push technology based on applicable probability matching and multidimensional context driving. By building a training sample set, including knowledge description vectors, case feature vectors, and the mapping Boolean matrix, two probability values, application and non-application, were calculated via a Bayesian theorem to describe the matching degree between knowledge and content. The push results were defined by the comparison between two probability values. The hierarchical design content models were built to filter the knowledge in push results. The rules of personalized knowledge push were sorted by multidimensional contexts, which include design knowledge, design context, design content, and the designer. A knowledge push system based on intellectualized design of CNC machine tools was used to confirm the feasibility of the proposed technology in engineering applications.
文摘China has entered a new era represented by the newly established China （Shanghai） Pilot Free Trade Zone, in which further reform and development of its financial system and capital market are highly prioritized. The trust as an important vehicle in development of the financial market in China as well as in the world will play an important role, and there will be more foreign elements involved in Chinese trusts. The Law of the People＇s Republic of China on Application of Laws in Civil Relations with Foreign Elements provides rules, in its article 17, on the application of laws to trusts, which symbolizes the formal creation of rules of conflict of laws in China in this area. However, it seems to cause more problems than it may resolve. For example, it may not always be possible for the parties to determine the appli- cable law through consultation and agreement, and the parties＇ right to choice of law should not be without limitation either. By allowing judges to choose from ＂the law of the situs where the trust property is situated＂ and ＂the law of the situs where the trust relationship occurred＂ in the absence of an effective choice of law by the parties may lead to a situation contrary to existing laws and may create uncertainty for the parties as well. This paper analyzes this article 17 by comparing it with the conflict law rules adopted in the United States and by the Hague Convention, identifies problems, and seeks to find solutions in order to promote the healthy development of the trust system in China.
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金supported by Youth Talent Project of Scientific Research Program of Hubei Provincial Department of Education under Grant Q20241809Doctoral Scientific Research Foundation of Hubei University of Automotive Technology under Grant 202404.
文摘As Internet of Things(IoT)applications expand,Mobile Edge Computing(MEC)has emerged as a promising architecture to overcome the real-time processing limitations of mobile devices.Edge-side computation offloading plays a pivotal role in MEC performance but remains challenging due to complex task topologies,conflicting objectives,and limited resources.This paper addresses high-dimensional multi-objective offloading for serial heterogeneous tasks in MEC.We jointly consider task heterogeneity,high-dimensional objectives,and flexible resource scheduling,modeling the problem as a Many-objective optimization.To solve it,we propose a flexible framework integrating an improved cooperative co-evolutionary algorithm based on decomposition(MOCC/D)and a flexible scheduling strategy.Experimental results on benchmark functions and simulation scenarios show that the proposed method outperforms existing approaches in both convergence and solution quality.
基金supported by the National Natural Science Foundational of China(Key Program),No.U24A20692(to CJZ)the National Natural Science Foundational of China,Nos.82101414(to MLJ),82371355(to CJZ)+4 种基金the National Natural Science Foundational of China for Excellent Young Scholars,No.82022019(to CJZ)Sichuan Special Fund for Distinguished Young Scholars,No.24NSFJQ0052(to CJZ)The Innovation and Entrepreneurial Team of Sichuan Tianfu Emei Program,No.CZ2024018(to CJZ)Funding for Distinguished Young Scholars of Sichuan Provincial People’s Hospital,No.30420230005(to CJZ)Funding for Distinguished Young Scholars of University of Electronic Science and Technology of China,No.A1098531023601381(to CJZ)。
文摘The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions,including regulating the inflammatory cascade in various autoimmune and inflammatory diseases,such as multiple sclerosis,neuromyelitis optica spectrum disorder,myasthenia gravis,Guillain–Barre syndrome,acute disseminated encephalomyelitis,diabetes,inflammatory skin diseases,joint inflammation,and cancer.Although the function of the interleukin-17 family has attracted increasing research attention over many years,the expression,function,and regulation mechanisms of different interleukin-17 members are complicated and still only partially understood.Currently,the interleukin-17A pathway is considered a critical therapeutic target for numerous immune and chronic inflammatory diseases,with several monoclonal antibodies against interleukin-17A having been successfully used in clinical practice.Whether other interleukin-17 members have the potential to be targeted in other diseases is still debated.This review first summarizes the recent advancements in understanding the physicochemical properties,physiological functions,cellular origins,and downstream signaling pathways of different members and corresponding receptors of the interleukin-17 family.Subsequently,the function of interleukin-17 in various immune diseases is discussed,and the important role of interleukin-17 in the pathological process of immune diseases is demonstrated from multiple perspectives.Then,the current status of targeted interleukin-17 therapy is summarized,and the effectiveness and safety of targeted interleukin-17 therapy are analyzed.Finally,the clinical application prospects of targeting the interleukin-17 pathway are discussed.
文摘In this paper, it is studied that the scattering effect is caused by microphones itself, on both wave magnitude and phase. The experimental method was found difficult to do this. We will apply the Boundary Element Method(BEM) to the problem and explain the results obtained. The numerical method seems to be a powerful tool in this situation.
基金supported in part by the Oregon Department of Transportation research study grant SPR-790the Center for Construction Research and Training(CPWR)through NIOSH cooperative agreement OH009762.
文摘Once considered conventional,the construction industry is gradually increasing its reliance on innovations such as the application of technologies in safety management.Given the growing literature on technology applications in safety management and the varying opinions on the utility of applied technologies,a systematic review that streamlines findings from past studies is indispensable to construction stakeholders.Although a number of review studies are available in the building construction sector,the level of fragmentation and uniqueness within the construction industry necessitates a review study specifically targeting the heavy civil sector.In response,the present study applies a three-step approach to identify and review articles pertinent to the safety of highway construction work zones.The factors considered include the number of publications per year,publication locations,and technology types.In addition,the present study proposes to broadly group work zone safety technologies(WZSTs)into three categories based on their primary purpose:speed reduction systems,intrusion prevention and warning systems,and human-machine-interaction detection systems.Key findings include WZST research trends,application of smart work zone systems,and the potential relationship between WZSTs and fatalities.The paper ends with the identification of six additional research areas aimed at deepening the understanding of technology’s role in highway safety management.The trend analysis and an in-depth discussion of each technology category alongside the identified research gaps will provide a substantial informative body of knowledge that both benefits current practitioners and directs researchers towards potential future studies.
文摘α-Trifluoromethyl ketones are a class of useful compounds with versatile applications.Their synthetic application via the transformation of the C—F bonds is of particular interest by allowing the synthesis of organic compounds with diverse structures.Herein,the advances in the research areas ofα-trifluoromethyl ketone synthesis and their defluorination reactions are reviewed.Discussion on the mechanisms of the typical reactions has also been provided,in hope of affording some guides to the chemistry ofα-trifluoromethyl ketones in the synthetic methods toward themselves and their derivatives.
基金funded by the National Natural Science Foundation of China(No.41962016)the Natural Science Foundation of NingXia(Nos.2023AAC02023,2023A1218,and 2021AAC02006).
文摘Soil improvement is one of the most important issues in geotechnical engineering practice.The wide application of traditional improvement techniques(cement/chemical materials)are limited due to damage ecological en-vironment and intensify carbon emissions.However,the use of microbially induced calcium carbonate pre-cipitation(MICP)to obtain bio-cement is a novel technique with the potential to induce soil stability,providing a low-carbon,environment-friendly,and sustainable integrated solution for some geotechnical engineering pro-blems in the environment.This paper presents a comprehensive review of the latest progress in soil improvement based on the MICP strategy.It systematically summarizes and overviews the mineralization mechanism,influ-encing factors,improved methods,engineering characteristics,and current field application status of the MICP.Additionally,it also explores the limitations and correspondingly proposes prospective applications via the MICP approach for soil improvement.This review indicates that the utilization of different environmental calcium-based wastes in MICP and combination of materials and MICP are conducive to meeting engineering and market demand.Furthermore,we recommend and encourage global collaborative study and practice with a view to commercializing MICP technique in the future.The current review purports to provide insights for engineers and interdisciplinary researchers,and guidance for future engineering applications.
