Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patien...Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1,2022 to May 31,2023 were selected as the control group.According to the equal group experiment method,80 elderly patients who were managed using FMEA from June 1,2023 to May 31,2024 were selected as the FMEA group.The control group received traditional nursing management,while the FMEA group applied FMEA to analyze failure causes,calculate Risk Priority Numbers(RPNs),identify failure modes with higher RPNs,analyze the influencing factors,develop improvement measures,and optimize processes.The RPN values and the incidence of DVT,as well as nursing satisfaction scores,were compared in the two groups.Results:Compared with the control group,the total RPN values of the FEMA group decreased significantly,with a reduction rate of 87.0%.Besides,the incidence of DVT was 1.3%in the FMEA group,lower than 10.0%in the control group(8/80).What’s more,the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group.Conclusion:The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT,lower RPN values,and improve nursing satisfaction.展开更多
In order to solve the problem that the current matchmaking methods for semantic web service mainly focus on the matchmaking of IO （inputs, outputs） descriptions which may result in one-sidedness, a description-logic...In order to solve the problem that the current matchmaking methods for semantic web service mainly focus on the matchmaking of IO （inputs, outputs） descriptions which may result in one-sidedness, a description-logic-based IOPE （inputs, outputs, preconditions, effects） description and matchmaking method is proposed for semantic web service. The description logic concept is used to annotate service IO and the description logic assertion is employed to describe service PE（preconditions, effects）. TBox subsumption checking is used to measure the subsumption relationship between IO descriptions of service request and advertising; ABox consistency checking is used for checking the logical implication between PE descriptions of service request and advertising. Based upon the logical implication, four kinds of PE matching degrees are proposed to measure and compare the pros and cons of the results of matchmaking. They are the exact, perfect, side-effect and common match. Experiments show that the method has a higher precision rate under the same recall rate compared with the existing method.展开更多
Based on statistic data of agricultural production and meteorological disasters in Liaoning Province from 1971 to 2008,the effect weight,disaster rate and variance value of main agro-meteorological disasters including...Based on statistic data of agricultural production and meteorological disasters in Liaoning Province from 1971 to 2008,the effect weight,disaster rate and variance value of main agro-meteorological disasters including drought,flood,wind,hail and frozen injury were calculated,and the variation characteristic of time series of agro-meteorological disasters was further analyzed,while the grade division and comprehensive evaluation of agro-meteorological disasters were carried out in our paper.The results showed that there was a negative correlation between grain yield and the degree of agro-meteorological disasters,and agro-meteorological disasters were relatively serious in 1989,1997 and 2000,with the reduction of grain yield.Meanwhile,the occurrence frequency of light disasters was highest,accounting for 39% of total years,and the adverse effect of agro-meteorological disasters on agricultural production became more and more severe decade by decade;the effect weight of drought reached 63%,so drought was the main agro-meteorological disaster influencing agricultural production.展开更多
On December 21, 20：10, a stray dog consecutively attacked 10 people in Lengshui Village, Ningyuan County, Yongzhou City, Hunan Province, China. The dog was killed by the local CDC staff and vicinity villager, its bra...On December 21, 20：10, a stray dog consecutively attacked 10 people in Lengshui Village, Ningyuan County, Yongzhou City, Hunan Province, China. The dog was killed by the local CDC staff and vicinity villager, its brain tissue sample was taken within 24 h. The epidemic focus was disinfected and the injured people received post exposure prophylaxis （PEP）. Pathogens were detected in the tissue sample by the provincial CDC. The immunity and safety of rabies vaccine were assayed after PEP, the injured people were regularly followed up in the following 2 y and 6 mon.展开更多
By X-ray powder diffraction technique and oxygen content analysis, a solid solution Sm1+xBa2-xCu3Oy has been determined in the range 0≤x≤0.4. When x<0.25. the Sm1+xBa2-xCu3Oy presents orthorhombic symmetry, and ...By X-ray powder diffraction technique and oxygen content analysis, a solid solution Sm1+xBa2-xCu3Oy has been determined in the range 0≤x≤0.4. When x<0.25. the Sm1+xBa2-xCu3Oy presents orthorhombic symmetry, and the orthorhombic-tetragonaJ transition ocCurs at x = 0.25. With the increase of x, TC decreases and finally breaks. The correlation between ox ygen content and phase structure at different quench temperatures related to Sm Ba2Cu3Oy has been investigated as well展开更多
It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics ar...It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics are summarized,and a defuzzification method is studied to obtain the fuzzy value table of the six fuzzy semantic scales.For the conflicts between experts in the traditional failure mode and effects analysis,a conflict-resolution algorithm is studied to obtain the failure risk order.Finally,a certain type of industrial valve is used as an example to prove the validity of the theory proposed in this paper.展开更多
Objective: To explore whether there is phenotypic modulation of mesangial cells in streptozotocin (STZ) induced diabetic rats and study the effect of Tujian Mixture (TJM) on it. Methods: SD rats were divided into the ...Objective: To explore whether there is phenotypic modulation of mesangial cells in streptozotocin (STZ) induced diabetic rats and study the effect of Tujian Mixture (TJM) on it. Methods: SD rats were divided into the normal control group , the unilateral nephrectomized control group , the STZ induced diabetes mellitus with unilateral nephrectomy model group , the Valsartan treated group (VT group, n=8) and the TJM treated group , rats in the latter two groups were modeled as in the DM group and treated with Valsartan (20 mg/kg·d) and TJM (20g/kg·d) respectively for 12 weeks. The expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β 1 (TGF-β 1) in rats’ glomeruli were observed by immunohistochemistry assay, and the ratio of α-SMA and TGF-β 1 positive area/total glomerule tuft area (SMA/GT and TGF/GT) were analyzed using computer-assisted image analysis software. Results: In the NC and the QC groups, only trace of α-SMA positive staining was found. But there was prominant α-SMA positive staining in glomeruli of the DM group, with SMA/GT and TGF/GT increased significantly , and marked increase of 24 hrs proteinuria excretion ( P<0 01). As compared with the DM group, the three indexes were all significantly lower in the VT and ZY groups , and the lowering of proteinuria was more significant in the ZY group than that in the VT group (P<0 01). Conclusion: The expression of α-SMA in glomeruli in STZ induced diabetic rats with unilateral nephrectomy is pronounced, indicating that phenotypic modulation of mesangial cells involvement in the pathogenesis of diabetic nephropathy. TJM and Valsartan can reduce 24 hrs proteinuria excretion, inhibit the phenotypic modulation of mesangial cells and the expression of TGF-β 1 in glomeruli of diabetic rats, and the effect of TJM is more potent than that of Valsartan in lowering urinary protein excretion..展开更多
[Objectives]To investigate the effect of healthcare failure mode and effect analysis(HFMEA)on reducing error risk of neonatal parenteral nutrition solution dispensing.[Methods]A research team was established to identi...[Objectives]To investigate the effect of healthcare failure mode and effect analysis(HFMEA)on reducing error risk of neonatal parenteral nutrition solution dispensing.[Methods]A research team was established to identify the failure mode(FM)in each link of the formulation process of neonatal parenteral nutrition solution by HFMEA,quantify the severity(S),occurrence(O)and detection(D)of FM,and evaluate FM by risk priority number(RPN).For FM with the values of RPN>16,failure cause analysis was conducted,and corresponding improvement measures were formulated.The weight coefficient and random consistency ratio(CR)of deployment process were calculated in Matlab R2018a by compiling the Analytic Hierarchy Process(AHP)program.Six months after the implementation of improvement measures,the implementation effect was evaluated by comparing the changes of the values of RPN which was evaluated comprehensively and the rate of dispensing errors before and after the implementation of HFMEA.[Results]In the preparation process of neonatal parenteral nutrition solution,a total of 13 FMs with medium and above risk were found,the weight coefficient of medical order review,dosing and mixing was 0.2703,the weight coefficient of drug dispensing check and review was 0.1432,the weight coefficient of print label was 0.1015,the weight coefficient of distribution was 0.0716,and CR=0.0491<0.1.After six months of intervention,the total RPN value decreased by 64.81%from 127.8 to 45.0.The deployment error rates were significantly lower after the implementation,and the difference was statistically significant(P<0.05).[Conclusions]HFMEA can effectively reduce the error risk in preparation of neonatal parenteral nutrition solution,improve the quality of dispensing and promote the safety of neonatal medication.展开更多
Nowadays,China has become the country that introduces the largest amount of foreign capital.Up to June 2008,the accumulative total number of foreign- invested enterprises in China is over 632 thousand:the total amount...Nowadays,China has become the country that introduces the largest amount of foreign capital.Up to June 2008,the accumulative total number of foreign- invested enterprises in China is over 632 thousand:the total amount of actual use of foreign capital is over US$582 billion.There are over 400 multination- als of top 500 investing in China,30 of which set up regional headquarters。展开更多
Failure mode and effect analysis(FMEA)is a preven-tative risk evaluation method used to evaluate and eliminate fail-ure modes within a system.However,the traditional FMEA method exhibits many deficiencies that pose ch...Failure mode and effect analysis(FMEA)is a preven-tative risk evaluation method used to evaluate and eliminate fail-ure modes within a system.However,the traditional FMEA method exhibits many deficiencies that pose challenges in prac-tical applications.To improve the conventional FMEA,many modified FMEA models have been suggested.However,the majority of them inadequately address consensus issues and focus on achieving a complete ranking of failure modes.In this research,we propose a new FMEA approach that integrates a two-stage consensus reaching model and a density peak clus-tering algorithm for the assessment and clustering of failure modes.Firstly,we employ the interval 2-tuple linguistic vari-ables(I2TLVs)to express the uncertain risk evaluations provided by FMEA experts.Then,a two-stage consensus reaching model is adopted to enable FMEA experts to reach a consensus.Next,failure modes are categorized into several risk clusters using a density peak clustering algorithm.Finally,the proposed FMEA is illustrated by a case study of load-bearing guidance devices of subway systems.The results show that the proposed FMEA model can more easily to describe the uncertain risk information of failure modes by using the I2TLVs;the introduction of an endogenous feedback mechanism and an exogenous feedback mechanism can accelerate the process of consensus reaching;and the density peak clustering of failure modes successfully improves the practical applicability of FMEA.展开更多
Two aspects of a new method,which can be used for seismic zoning,are introduced in this paper.On the one hand,the approach to estimate b value and annual activity rate proposed by Kijko and Sellevoll needs to use the ...Two aspects of a new method,which can be used for seismic zoning,are introduced in this paper.On the one hand,the approach to estimate b value and annual activity rate proposed by Kijko and Sellevoll needs to use the earthquake catalogue.The existing earthquake catalogue contains both historical and recent instrumental data sets and it is inadequate to use only one part.Combining the large number of historical events with recent complete records and taking the magnitude uncertainty into account,Kijko’s method gives the maximum likelihood estimation of b value and annual activity rate,which might be more realistic.On the other hand,this method considers the source zone boundary uncertainty in seismic hazard analysis,which means the earthquake activity rate across a boundary of a source zone changes smoothly instead of abruptly and avoids too large a gradient in the calculated results.展开更多
Objective: to test the clinical nursing method and effect of using IOE tube in patients with dysphagia after stroke. Methods: 62 patients with dysphagia caused by cerebral apoplexy were selected as test subjects, and ...Objective: to test the clinical nursing method and effect of using IOE tube in patients with dysphagia after stroke. Methods: 62 patients with dysphagia caused by cerebral apoplexy were selected as test subjects, and the treatment time in our hospital was from January 2021 to January 2022. According to the method of touching the ball, 62 test subjects were divided into 2 groups, with 31 test subjects in each group. Routine nursing intervention and IOE management nursing intervention were implemented respectively. The scores of dysphagia, nursing satisfaction and quality of life of the two groups were observed. Results: after nursing intervention, the swallowing disorder scores of the two groups were compared. The nursing intervention group was lower than the routine group (P 0.05);The quality of life and nursing satisfaction in the nursing intervention group were higher than those in the routine group (P 0.05). Conclusion: the clinical nursing effect of using IOE tube for patients with dysphagia is more ideal and can be widely used in clinic.展开更多
Objective: the experiment will apply failure mode and effect analysis combined with PDCA cycle management to hepatobiliary surgery patients to jointly improve the nursing results of patients. Methods: the experiment s...Objective: the experiment will apply failure mode and effect analysis combined with PDCA cycle management to hepatobiliary surgery patients to jointly improve the nursing results of patients. Methods: the experiment selected the patients of hepatobiliary surgery as the object of this investigation. In terms of time period, we retrieved 120 patients who received corresponding treatment in our hospital from June 2019 to December 2020. They were divided into two groups by random number method. Patients in the control group were given routine nursing measures, while patients in the observation group were given failure mode and effect analysis combined with PDCA cycle management to compare the nursing results. Results: from the point of view of nursing quality, the incidence of nursing errors in the observation group was 1.7% and that in the control group was 6.7%, which was statistically significant (P < 0.05). At the same time, the satisfaction degree of the patients in the observation group was 98.3%, which was better than that of the control group (90.0%), and the difference was statistically significant (P < 0.05). Finally, the incidence of complications was 8.3% (5/60) in the observation group and 18.3% (11/60) in the control group, the difference was statistically significant (P < 0.05). Conclusion: the application of failure mode and effect analysis combined with PDCA circulation management mode has good effect on rehabilitation nursing of patients with hepatobiliary surgery diseases, can improve the overall quality of nursing work, and has promotional value.展开更多
To clone human arresten gene and investigate biological activity of the recombinant protein.Methods Human arresten gene was obtained from the plasmid pGEMArr and subcloned into the BamHⅠ and Pst Ⅰ restriction sites ...To clone human arresten gene and investigate biological activity of the recombinant protein.Methods Human arresten gene was obtained from the plasmid pGEMArr and subcloned into the BamHⅠ and Pst Ⅰ restriction sites of prokaryotic expression vector pRSET containing T7 promoter.The recombinant plasmid pRSETAN was subsequently transformed into the strain E.coli BL21(DE3),and the target gene was expressed under induction of IPTG.The expressed protein was extracted,purified by Ni 2+ chelation affinity chromatography and refoled.The effect of the recombinant protein on proliferation of human umbilical vein endothelial cells (HUVECs) was also analyzed with the MTT assay.Results Endonuclease digesting and DNA sequencing confirmed that the arresten gene was correctly inserted into the expression vector.The recombinant protein was hightly expressed in the form of inclusion body in the host bacteria after induction.SDS-PAGE analysis revealed that the recombinant protein with a molecular weight of 26×103 amounted to 27% of the total bacterial proteins.The purity of the expected protein could reach over 96% through affinity chromatography.After renaturation,the recombinant protein could reach over 96% through affinity chromatography.After renaturation,the recombinant protein could significantly suppress proliferation of human umbilical vein endothelia cells(HUVECs) induced by vascular endothelial growth factor(VEGF).Conclusion Human arresten gene was successfully cloned into the expression vector pRSET and expressed at high level in Escherichia coli.Purified and refolded arresten protein could effectively inhibit proliferation of vascular endothelia cells.2 refs.展开更多
Labor education is an essential component of college and university education that can help students to develop a strong work ethic,acquire practical skills,and better understand the value of work.Strengthening labor ...Labor education is an essential component of college and university education that can help students to develop a strong work ethic,acquire practical skills,and better understand the value of work.Strengthening labor education for college and university students is an urgent need of the high-quality development of the society and the internal requirement of promoting the all-round development of individuals.This study analyzes the importance of strengthening labor education for college and university students in the new era and proposes four practical pathways which draw on labor courses and campus activities,social practices,scientific research projects,and internships.After implementing these pathways,a survey of 967 students showed that students’understanding and awareness of labor was deepened,their hands-on skills and interests in science and labor practices were improved,and they became more cordially respectful to the working class.Taken together,the exploration and practice of these pathways helps college and university students to recognize their abilities,strengths,and interests,and guides them to form good labor habits that permeate all aspects of their studies and lives.展开更多
Aesthetic education and ideological and political education undertake the educational responsibilities of educating people with beauty and cultivating people with morals,respectively.The innovation of aesthetic educat...Aesthetic education and ideological and political education undertake the educational responsibilities of educating people with beauty and cultivating people with morals,respectively.The innovation of aesthetic education and the reform of ideological and political education have common educational goals and target students.Integrating aesthetic education with ideological and political education can promote the overall healthy development of students,which has both historical and practical significance.In this paper,the importance and characteristics of integrating aesthetic education with ideological and political education in colleges and universities are analyzed from multiple dimensions,and four feasible ways of integrating aesthetic education with ideological and political education are proposed.The latter draws on extracurricular activities,emotional touch,a pleasant aesthetic atmosphere,and educational synergy to improve students’aesthetic literacy and cultivate correct ideological and political concepts among students.A survey of 1,047 students showed that the understanding and acceptance of ideological and political education were strengthened and improved after implementing these innovative integration ways.Taken together,the exploration and practice of these integration ways contribute to expanding the effect of ideological and political education in the new era and constitute important parts of the reform of college and university education in the new journey.展开更多
The Healthcare Failure Mode and Effect Analysis(HFMEA)model,as a proactive risk assessment tool,systematically identifies potential infection risk points during surgical procedures and evaluates the failure modes and ...The Healthcare Failure Mode and Effect Analysis(HFMEA)model,as a proactive risk assessment tool,systematically identifies potential infection risk points during surgical procedures and evaluates the failure modes and their effects that may result from these risks.Evidence-based medicine,on the other hand,emphasizes making medical decisions based on the best available evidence.Combining these two approaches can provide more scientific and effective strategies for preventing infection in operating rooms.This paper delves into the application of the HFMEA model and evidence-based medicine in the field of infection prevention in operating rooms,aiming to offer new perspectives and methods for this critical aspect of healthcare.展开更多
文摘Purpose:To evaluate the effects of healthcare failure mode and effect analysis(FMEA)on the prevention of deep venous thrombosis(DVT)in elderly patients undergoing femoral fracture surgery.Methods:Eighty elderly patients undergoing femoral fracture surgery who did not apply FMEA in Suzhou BenQ Medical Center from June 1,2022 to May 31,2023 were selected as the control group.According to the equal group experiment method,80 elderly patients who were managed using FMEA from June 1,2023 to May 31,2024 were selected as the FMEA group.The control group received traditional nursing management,while the FMEA group applied FMEA to analyze failure causes,calculate Risk Priority Numbers(RPNs),identify failure modes with higher RPNs,analyze the influencing factors,develop improvement measures,and optimize processes.The RPN values and the incidence of DVT,as well as nursing satisfaction scores,were compared in the two groups.Results:Compared with the control group,the total RPN values of the FEMA group decreased significantly,with a reduction rate of 87.0%.Besides,the incidence of DVT was 1.3%in the FMEA group,lower than 10.0%in the control group(8/80).What’s more,the patients in the FMEA group were more satisfied with the nursing service compared with the patients in the control group.Conclusion:The application of the FMEA in elderly patients undergoing femoral fracture surgery has demonstrated its potential to prevent the incidence of DVT,lower RPN values,and improve nursing satisfaction.
文摘In order to solve the problem that the current matchmaking methods for semantic web service mainly focus on the matchmaking of IO （inputs, outputs） descriptions which may result in one-sidedness, a description-logic-based IOPE （inputs, outputs, preconditions, effects） description and matchmaking method is proposed for semantic web service. The description logic concept is used to annotate service IO and the description logic assertion is employed to describe service PE（preconditions, effects）. TBox subsumption checking is used to measure the subsumption relationship between IO descriptions of service request and advertising; ABox consistency checking is used for checking the logical implication between PE descriptions of service request and advertising. Based upon the logical implication, four kinds of PE matching degrees are proposed to measure and compare the pros and cons of the results of matchmaking. They are the exact, perfect, side-effect and common match. Experiments show that the method has a higher precision rate under the same recall rate compared with the existing method.
基金Supported by Scientific and Technological Development Project of Shenyang Regional Climate Center(201015)~~
文摘Based on statistic data of agricultural production and meteorological disasters in Liaoning Province from 1971 to 2008,the effect weight,disaster rate and variance value of main agro-meteorological disasters including drought,flood,wind,hail and frozen injury were calculated,and the variation characteristic of time series of agro-meteorological disasters was further analyzed,while the grade division and comprehensive evaluation of agro-meteorological disasters were carried out in our paper.The results showed that there was a negative correlation between grain yield and the degree of agro-meteorological disasters,and agro-meteorological disasters were relatively serious in 1989,1997 and 2000,with the reduction of grain yield.Meanwhile,the occurrence frequency of light disasters was highest,accounting for 39% of total years,and the adverse effect of agro-meteorological disasters on agricultural production became more and more severe decade by decade;the effect weight of drought reached 63%,so drought was the main agro-meteorological disaster influencing agricultural production.
基金supported by the National Department Public Benefit Research Foundation(201103032)
文摘On December 21, 20：10, a stray dog consecutively attacked 10 people in Lengshui Village, Ningyuan County, Yongzhou City, Hunan Province, China. The dog was killed by the local CDC staff and vicinity villager, its brain tissue sample was taken within 24 h. The epidemic focus was disinfected and the injured people received post exposure prophylaxis （PEP）. Pathogens were detected in the tissue sample by the provincial CDC. The immunity and safety of rabies vaccine were assayed after PEP, the injured people were regularly followed up in the following 2 y and 6 mon.
文摘By X-ray powder diffraction technique and oxygen content analysis, a solid solution Sm1+xBa2-xCu3Oy has been determined in the range 0≤x≤0.4. When x<0.25. the Sm1+xBa2-xCu3Oy presents orthorhombic symmetry, and the orthorhombic-tetragonaJ transition ocCurs at x = 0.25. With the increase of x, TC decreases and finally breaks. The correlation between ox ygen content and phase structure at different quench temperatures related to Sm Ba2Cu3Oy has been investigated as well
基金National Natural Science Foundation of China(No.51565019)the Scientific Research Start-Up Program of Tongji University,China(No.20141110)
文摘It is not objective to rate the decision-making factors in the traditional failure mode and effect analysis,so fuzzy semantic theory is used in this paper.Six fuzzy semantic scales and their corresponding semantics are summarized,and a defuzzification method is studied to obtain the fuzzy value table of the six fuzzy semantic scales.For the conflicts between experts in the traditional failure mode and effects analysis,a conflict-resolution algorithm is studied to obtain the failure risk order.Finally,a certain type of industrial valve is used as an example to prove the validity of the theory proposed in this paper.
文摘Objective: To explore whether there is phenotypic modulation of mesangial cells in streptozotocin (STZ) induced diabetic rats and study the effect of Tujian Mixture (TJM) on it. Methods: SD rats were divided into the normal control group , the unilateral nephrectomized control group , the STZ induced diabetes mellitus with unilateral nephrectomy model group , the Valsartan treated group (VT group, n=8) and the TJM treated group , rats in the latter two groups were modeled as in the DM group and treated with Valsartan (20 mg/kg·d) and TJM (20g/kg·d) respectively for 12 weeks. The expression of α-smooth muscle actin (α-SMA) and transforming growth factor-β 1 (TGF-β 1) in rats’ glomeruli were observed by immunohistochemistry assay, and the ratio of α-SMA and TGF-β 1 positive area/total glomerule tuft area (SMA/GT and TGF/GT) were analyzed using computer-assisted image analysis software. Results: In the NC and the QC groups, only trace of α-SMA positive staining was found. But there was prominant α-SMA positive staining in glomeruli of the DM group, with SMA/GT and TGF/GT increased significantly , and marked increase of 24 hrs proteinuria excretion ( P<0 01). As compared with the DM group, the three indexes were all significantly lower in the VT and ZY groups , and the lowering of proteinuria was more significant in the ZY group than that in the VT group (P<0 01). Conclusion: The expression of α-SMA in glomeruli in STZ induced diabetic rats with unilateral nephrectomy is pronounced, indicating that phenotypic modulation of mesangial cells involvement in the pathogenesis of diabetic nephropathy. TJM and Valsartan can reduce 24 hrs proteinuria excretion, inhibit the phenotypic modulation of mesangial cells and the expression of TGF-β 1 in glomeruli of diabetic rats, and the effect of TJM is more potent than that of Valsartan in lowering urinary protein excretion..
基金Young Scholar Program of Hebei Pharmaceutical Association Hospital Pharmaceutical Research Project(2020—Hbsyxhqn0029)Science and Technology Research and Development Project of Chengde City,Hebei Province(201706A043).
文摘[Objectives]To investigate the effect of healthcare failure mode and effect analysis(HFMEA)on reducing error risk of neonatal parenteral nutrition solution dispensing.[Methods]A research team was established to identify the failure mode(FM)in each link of the formulation process of neonatal parenteral nutrition solution by HFMEA,quantify the severity(S),occurrence(O)and detection(D)of FM,and evaluate FM by risk priority number(RPN).For FM with the values of RPN>16,failure cause analysis was conducted,and corresponding improvement measures were formulated.The weight coefficient and random consistency ratio(CR)of deployment process were calculated in Matlab R2018a by compiling the Analytic Hierarchy Process(AHP)program.Six months after the implementation of improvement measures,the implementation effect was evaluated by comparing the changes of the values of RPN which was evaluated comprehensively and the rate of dispensing errors before and after the implementation of HFMEA.[Results]In the preparation process of neonatal parenteral nutrition solution,a total of 13 FMs with medium and above risk were found,the weight coefficient of medical order review,dosing and mixing was 0.2703,the weight coefficient of drug dispensing check and review was 0.1432,the weight coefficient of print label was 0.1015,the weight coefficient of distribution was 0.0716,and CR=0.0491<0.1.After six months of intervention,the total RPN value decreased by 64.81%from 127.8 to 45.0.The deployment error rates were significantly lower after the implementation,and the difference was statistically significant(P<0.05).[Conclusions]HFMEA can effectively reduce the error risk in preparation of neonatal parenteral nutrition solution,improve the quality of dispensing and promote the safety of neonatal medication.
文摘Nowadays,China has become the country that introduces the largest amount of foreign capital.Up to June 2008,the accumulative total number of foreign- invested enterprises in China is over 632 thousand:the total amount of actual use of foreign capital is over US$582 billion.There are over 400 multination- als of top 500 investing in China,30 of which set up regional headquarters。
基金supported by the Fundamental Research Funds for the Central Universities(22120240094)Humanities and Social Science Fund of Ministry of Education China(22YJA630082).
文摘Failure mode and effect analysis(FMEA)is a preven-tative risk evaluation method used to evaluate and eliminate fail-ure modes within a system.However,the traditional FMEA method exhibits many deficiencies that pose challenges in prac-tical applications.To improve the conventional FMEA,many modified FMEA models have been suggested.However,the majority of them inadequately address consensus issues and focus on achieving a complete ranking of failure modes.In this research,we propose a new FMEA approach that integrates a two-stage consensus reaching model and a density peak clus-tering algorithm for the assessment and clustering of failure modes.Firstly,we employ the interval 2-tuple linguistic vari-ables(I2TLVs)to express the uncertain risk evaluations provided by FMEA experts.Then,a two-stage consensus reaching model is adopted to enable FMEA experts to reach a consensus.Next,failure modes are categorized into several risk clusters using a density peak clustering algorithm.Finally,the proposed FMEA is illustrated by a case study of load-bearing guidance devices of subway systems.The results show that the proposed FMEA model can more easily to describe the uncertain risk information of failure modes by using the I2TLVs;the introduction of an endogenous feedback mechanism and an exogenous feedback mechanism can accelerate the process of consensus reaching;and the density peak clustering of failure modes successfully improves the practical applicability of FMEA.
基金This project was sponsored by the State Seismological Bureau (85070102), China
文摘Two aspects of a new method,which can be used for seismic zoning,are introduced in this paper.On the one hand,the approach to estimate b value and annual activity rate proposed by Kijko and Sellevoll needs to use the earthquake catalogue.The existing earthquake catalogue contains both historical and recent instrumental data sets and it is inadequate to use only one part.Combining the large number of historical events with recent complete records and taking the magnitude uncertainty into account,Kijko’s method gives the maximum likelihood estimation of b value and annual activity rate,which might be more realistic.On the other hand,this method considers the source zone boundary uncertainty in seismic hazard analysis,which means the earthquake activity rate across a boundary of a source zone changes smoothly instead of abruptly and avoids too large a gradient in the calculated results.
文摘Objective: to test the clinical nursing method and effect of using IOE tube in patients with dysphagia after stroke. Methods: 62 patients with dysphagia caused by cerebral apoplexy were selected as test subjects, and the treatment time in our hospital was from January 2021 to January 2022. According to the method of touching the ball, 62 test subjects were divided into 2 groups, with 31 test subjects in each group. Routine nursing intervention and IOE management nursing intervention were implemented respectively. The scores of dysphagia, nursing satisfaction and quality of life of the two groups were observed. Results: after nursing intervention, the swallowing disorder scores of the two groups were compared. The nursing intervention group was lower than the routine group (P 0.05);The quality of life and nursing satisfaction in the nursing intervention group were higher than those in the routine group (P 0.05). Conclusion: the clinical nursing effect of using IOE tube for patients with dysphagia is more ideal and can be widely used in clinic.
文摘Objective: the experiment will apply failure mode and effect analysis combined with PDCA cycle management to hepatobiliary surgery patients to jointly improve the nursing results of patients. Methods: the experiment selected the patients of hepatobiliary surgery as the object of this investigation. In terms of time period, we retrieved 120 patients who received corresponding treatment in our hospital from June 2019 to December 2020. They were divided into two groups by random number method. Patients in the control group were given routine nursing measures, while patients in the observation group were given failure mode and effect analysis combined with PDCA cycle management to compare the nursing results. Results: from the point of view of nursing quality, the incidence of nursing errors in the observation group was 1.7% and that in the control group was 6.7%, which was statistically significant (P < 0.05). At the same time, the satisfaction degree of the patients in the observation group was 98.3%, which was better than that of the control group (90.0%), and the difference was statistically significant (P < 0.05). Finally, the incidence of complications was 8.3% (5/60) in the observation group and 18.3% (11/60) in the control group, the difference was statistically significant (P < 0.05). Conclusion: the application of failure mode and effect analysis combined with PDCA circulation management mode has good effect on rehabilitation nursing of patients with hepatobiliary surgery diseases, can improve the overall quality of nursing work, and has promotional value.
文摘To clone human arresten gene and investigate biological activity of the recombinant protein.Methods Human arresten gene was obtained from the plasmid pGEMArr and subcloned into the BamHⅠ and Pst Ⅰ restriction sites of prokaryotic expression vector pRSET containing T7 promoter.The recombinant plasmid pRSETAN was subsequently transformed into the strain E.coli BL21(DE3),and the target gene was expressed under induction of IPTG.The expressed protein was extracted,purified by Ni 2+ chelation affinity chromatography and refoled.The effect of the recombinant protein on proliferation of human umbilical vein endothelial cells (HUVECs) was also analyzed with the MTT assay.Results Endonuclease digesting and DNA sequencing confirmed that the arresten gene was correctly inserted into the expression vector.The recombinant protein was hightly expressed in the form of inclusion body in the host bacteria after induction.SDS-PAGE analysis revealed that the recombinant protein with a molecular weight of 26×103 amounted to 27% of the total bacterial proteins.The purity of the expected protein could reach over 96% through affinity chromatography.After renaturation,the recombinant protein could reach over 96% through affinity chromatography.After renaturation,the recombinant protein could significantly suppress proliferation of human umbilical vein endothelia cells(HUVECs) induced by vascular endothelial growth factor(VEGF).Conclusion Human arresten gene was successfully cloned into the expression vector pRSET and expressed at high level in Escherichia coli.Purified and refolded arresten protein could effectively inhibit proliferation of vascular endothelia cells.2 refs.
基金supported by Research Project of Henan Provincial Social Science Circles Federation(SKL-2023-1059)Higher Education Research Project of Henan Association of Higher Education(2021SXHLX175)Research Projects from Xinxiang Municipal Social Science Circles Federation(SKL-2023-126 and SKL-2023-136).
文摘Labor education is an essential component of college and university education that can help students to develop a strong work ethic,acquire practical skills,and better understand the value of work.Strengthening labor education for college and university students is an urgent need of the high-quality development of the society and the internal requirement of promoting the all-round development of individuals.This study analyzes the importance of strengthening labor education for college and university students in the new era and proposes four practical pathways which draw on labor courses and campus activities,social practices,scientific research projects,and internships.After implementing these pathways,a survey of 967 students showed that students’understanding and awareness of labor was deepened,their hands-on skills and interests in science and labor practices were improved,and they became more cordially respectful to the working class.Taken together,the exploration and practice of these pathways helps college and university students to recognize their abilities,strengths,and interests,and guides them to form good labor habits that permeate all aspects of their studies and lives.
基金Research Projects from Xinxiang Municipal Social Science Circles Federation(SKL-2023-126 and SKL-2023-136).
文摘Aesthetic education and ideological and political education undertake the educational responsibilities of educating people with beauty and cultivating people with morals,respectively.The innovation of aesthetic education and the reform of ideological and political education have common educational goals and target students.Integrating aesthetic education with ideological and political education can promote the overall healthy development of students,which has both historical and practical significance.In this paper,the importance and characteristics of integrating aesthetic education with ideological and political education in colleges and universities are analyzed from multiple dimensions,and four feasible ways of integrating aesthetic education with ideological and political education are proposed.The latter draws on extracurricular activities,emotional touch,a pleasant aesthetic atmosphere,and educational synergy to improve students’aesthetic literacy and cultivate correct ideological and political concepts among students.A survey of 1,047 students showed that the understanding and acceptance of ideological and political education were strengthened and improved after implementing these innovative integration ways.Taken together,the exploration and practice of these integration ways contribute to expanding the effect of ideological and political education in the new era and constitute important parts of the reform of college and university education in the new journey.
文摘The Healthcare Failure Mode and Effect Analysis(HFMEA)model,as a proactive risk assessment tool,systematically identifies potential infection risk points during surgical procedures and evaluates the failure modes and their effects that may result from these risks.Evidence-based medicine,on the other hand,emphasizes making medical decisions based on the best available evidence.Combining these two approaches can provide more scientific and effective strategies for preventing infection in operating rooms.This paper delves into the application of the HFMEA model and evidence-based medicine in the field of infection prevention in operating rooms,aiming to offer new perspectives and methods for this critical aspect of healthcare.
