We are in the midst of exciting advancements in new technologies and innovative research in precision medicine.Among these,3D printing is one of the most frequently seen in clinical orthopaedic settings.This new techn...We are in the midst of exciting advancements in new technologies and innovative research in precision medicine.Among these,3D printing is one of the most frequently seen in clinical orthopaedic settings.This new technique has been adopted in a vast range of applications in spine surgery,such as producing anatomical models,surgical templates,preoperative plans,and spinal implants.Some studies on 3D printing technologies in spine surgery have reported the benefits of this emerging technology with more effective manufacturing,more visualisation for communication,and more precise navigation for screw insertion and osteotomy.In addition,in customised implant design and fabrication processes,3D printing products with anatomical adaptions and complex porous microstructure show some attractive advantages in terms of fit and osteoinductivity.However,there are still some concerns about the safety and feasibility of the application of 3D printing technology in spine surgery.We review the literature on and share our experiences with the application of 3D printing from the beginning of collaborations between doctors and computer-aided design(CAD)designers to the final follow-up of clinical patients.展开更多
We cloned cDNAs for Xenopus aldolases A, B and C. These three aldolase genes are localized on different chromosomes as a single copy gene. In the adult, the aldolase A gene is expressed extensively in muscle tissues, ...We cloned cDNAs for Xenopus aldolases A, B and C. These three aldolase genes are localized on different chromosomes as a single copy gene. In the adult, the aldolase A gene is expressed extensively in muscle tissues, whereas the aldolase B gene is expressed strongly in kidney, liver, stomach and intestine, while the aldolase C gene is expressed in brain, heart and ovary. In oocytes aldolase A and C mRNAs, but not aldolase B mRNA, are extensively transcribed. Thus, aldolase A and C mRNAs, but not B mRNA, occur abundantly in eggs as maternal mRNAs, and strong expression of aldolase B mRNA is seen only after the late neurula stage. We conclude that aldolase A and C mRNAs are major aldolase mRNAs in early stages of Xenopus embryogenesis which proceeds utilizing yolk as the only energy source, aldolase B mRNA, on the other hand, is expressed only later in development in tissues which are required for dietary fructose metabolism.We also isolated the Xenopus aldolase C genomic gene (ca. 12 kb) and found that its promoter (ca. 2 kb)contains regions necessary for tissue-specific expression and also a GC rich region which is essential for basal transcriptional activity.展开更多
The Josephinum Medical History Museum in Vienna houses an extensive collection of anatomical wax models,including a detailed model of the human liver(Figure 1).This unique collection was originally acquired for the Mi...The Josephinum Medical History Museum in Vienna houses an extensive collection of anatomical wax models,including a detailed model of the human liver(Figure 1).This unique collection was originally acquired for the Military Medical-Surgical Academy,established in Vienna in 1785 by Emperor Joseph II,who was also,at that time,the Archduke of Austria(1).展开更多
Objective： To explore the mechanical behavior of lumbar spine loaded by stress and provide the mechanical basis for clinical analysis and judgement of lumbar spine fracture classification, mechanical distribution and...Objective： To explore the mechanical behavior of lumbar spine loaded by stress and provide the mechanical basis for clinical analysis and judgement of lumbar spine fracture classification, mechanical distribution and static stress. Methods： By means of computer simulation method, the constructed lumbar spine three-dimensional model was introduced into three-dimensional finite element analysis by software Ansys 7.0. The lumbar spine mechanical behavior in different parts of the stress loading were calculated. Impact load is 0-8000 N. The peak value was 8000 N. The loading time is 0-40 minutes. The values of the main stress, stress distribution and the lumbar spine unit displacement in the direction of main stress were analyzed. Results： The lumbar spine model was divided into a total of 121 239 nodes, 112 491 units. It could objectively reflect the true anatomy of lumbar spine and its biomechanical behavior and obtain the end-plate images under different stress. The stress distribution on the lumbar intervertebral disc （L3-L4） under the axial, lateral flexion and extension stress, and the displacement trace of the corresponding processus articularis were analyzed. Conclusion： It is helpful to analyze the stress distribution of lumbar spine and units displacement in static stress loading in the clinical research of lumbar spine injury and the distribution of internal stress.展开更多
In the last few decades,the utilization of 3D printing has transcended its niche status to become an indispensable tool in medicine,and its ability to swiftly produce intricate geometries,coupled with its cost-effecti...In the last few decades,the utilization of 3D printing has transcended its niche status to become an indispensable tool in medicine,and its ability to swiftly produce intricate geometries,coupled with its cost-effectiveness,has propelled its adoption across multiple surgical specialties,including plastic,abdominal,and orthopedic surgery.Notably,in plastic surgery,3D printing has revolutionized several facets of patient care,spanning from the creation of anatomical models for surgical planning and medical education to the fabrication of custom implants and molds and the creation of surgical guides.This review delves into the expansive landscape of 3D printing applications within plastic surgery,examining the diverse modalities and materials employed.By leveraging advancements in printing processes and materials,surgeons are empowered to refine established techniques and develop novel solutions tailored to individual patient needs.As the technology continues to mature,its impact on plastic surgery is poised to deepen,promising further enhancements in surgical precision,patient care,and functional and aesthetic outcomes.This review underscores the transformative potential of 3D printing in shaping the future landscape of plastic surgery,driving continuous improvement and innovation in the field.展开更多
基金the National Key Research and Development Program of China(No.2017YFB1104104)the Special Foundation for Innovation of Science and Technology of Shanghai Jiao Tong University(Nos.GXQ201810 and GXQ202003)。
文摘We are in the midst of exciting advancements in new technologies and innovative research in precision medicine.Among these,3D printing is one of the most frequently seen in clinical orthopaedic settings.This new technique has been adopted in a vast range of applications in spine surgery,such as producing anatomical models,surgical templates,preoperative plans,and spinal implants.Some studies on 3D printing technologies in spine surgery have reported the benefits of this emerging technology with more effective manufacturing,more visualisation for communication,and more precise navigation for screw insertion and osteotomy.In addition,in customised implant design and fabrication processes,3D printing products with anatomical adaptions and complex porous microstructure show some attractive advantages in terms of fit and osteoinductivity.However,there are still some concerns about the safety and feasibility of the application of 3D printing technology in spine surgery.We review the literature on and share our experiences with the application of 3D printing from the beginning of collaborations between doctors and computer-aided design(CAD)designers to the final follow-up of clinical patients.
文摘We cloned cDNAs for Xenopus aldolases A, B and C. These three aldolase genes are localized on different chromosomes as a single copy gene. In the adult, the aldolase A gene is expressed extensively in muscle tissues, whereas the aldolase B gene is expressed strongly in kidney, liver, stomach and intestine, while the aldolase C gene is expressed in brain, heart and ovary. In oocytes aldolase A and C mRNAs, but not aldolase B mRNA, are extensively transcribed. Thus, aldolase A and C mRNAs, but not B mRNA, occur abundantly in eggs as maternal mRNAs, and strong expression of aldolase B mRNA is seen only after the late neurula stage. We conclude that aldolase A and C mRNAs are major aldolase mRNAs in early stages of Xenopus embryogenesis which proceeds utilizing yolk as the only energy source, aldolase B mRNA, on the other hand, is expressed only later in development in tissues which are required for dietary fructose metabolism.We also isolated the Xenopus aldolase C genomic gene (ca. 12 kb) and found that its promoter (ca. 2 kb)contains regions necessary for tissue-specific expression and also a GC rich region which is essential for basal transcriptional activity.
文摘The Josephinum Medical History Museum in Vienna houses an extensive collection of anatomical wax models,including a detailed model of the human liver(Figure 1).This unique collection was originally acquired for the Military Medical-Surgical Academy,established in Vienna in 1785 by Emperor Joseph II,who was also,at that time,the Archduke of Austria(1).
文摘Objective： To explore the mechanical behavior of lumbar spine loaded by stress and provide the mechanical basis for clinical analysis and judgement of lumbar spine fracture classification, mechanical distribution and static stress. Methods： By means of computer simulation method, the constructed lumbar spine three-dimensional model was introduced into three-dimensional finite element analysis by software Ansys 7.0. The lumbar spine mechanical behavior in different parts of the stress loading were calculated. Impact load is 0-8000 N. The peak value was 8000 N. The loading time is 0-40 minutes. The values of the main stress, stress distribution and the lumbar spine unit displacement in the direction of main stress were analyzed. Results： The lumbar spine model was divided into a total of 121 239 nodes, 112 491 units. It could objectively reflect the true anatomy of lumbar spine and its biomechanical behavior and obtain the end-plate images under different stress. The stress distribution on the lumbar intervertebral disc （L3-L4） under the axial, lateral flexion and extension stress, and the displacement trace of the corresponding processus articularis were analyzed. Conclusion： It is helpful to analyze the stress distribution of lumbar spine and units displacement in static stress loading in the clinical research of lumbar spine injury and the distribution of internal stress.
文摘In the last few decades,the utilization of 3D printing has transcended its niche status to become an indispensable tool in medicine,and its ability to swiftly produce intricate geometries,coupled with its cost-effectiveness,has propelled its adoption across multiple surgical specialties,including plastic,abdominal,and orthopedic surgery.Notably,in plastic surgery,3D printing has revolutionized several facets of patient care,spanning from the creation of anatomical models for surgical planning and medical education to the fabrication of custom implants and molds and the creation of surgical guides.This review delves into the expansive landscape of 3D printing applications within plastic surgery,examining the diverse modalities and materials employed.By leveraging advancements in printing processes and materials,surgeons are empowered to refine established techniques and develop novel solutions tailored to individual patient needs.As the technology continues to mature,its impact on plastic surgery is poised to deepen,promising further enhancements in surgical precision,patient care,and functional and aesthetic outcomes.This review underscores the transformative potential of 3D printing in shaping the future landscape of plastic surgery,driving continuous improvement and innovation in the field.
