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Effect of the firing position on aiming error and probability of hit 被引量:3
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作者 D.Corriveau C.A.Rabbath A.Goudreau 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2019年第5期713-720,共8页
Sources of dispersions that contribute to delivery error and reduce the soldier performance in terms of hit probability are numerous.In order to improve the warfighter performance,the source of the errors contributing... Sources of dispersions that contribute to delivery error and reduce the soldier performance in terms of hit probability are numerous.In order to improve the warfighter performance,the source of the errors contributing to the inaccuracy and dispersion of the weapon systems must be understood.They include ammunition dispersion error,gun dispersion,aerodynamic jump and the aiming error.The aiming error or gun pointing error is defined as the angle between the gun muzzle at the instant the trigger is pulled and the line of fire that corresponds to the intendent aim point.This is a round-to-round error.In weapons systems that include the rifle,the ammunition,a sight and a gunner,the aiming error was shown to be the single most important source of dispersion for the regular infantryman.In other words,for the general purpose rifle weapon system,the weak link is often the human.In order to verify and quantify this assertion,an experimental investigation was carried out to determine the aiming error associated with general purpose rifle fired by infantryman.The aiming error was evaluated for various firing positions and scenarios using infantryman for ranges varying between 100 m and 500 m.The results show that the aiming error is the main contributor to dispersion for the general purpose rifle fired by a non-specialized infantryman.The aiming error induced dispersion for unstressed and rested gunners is shown to be at best equivalent to that of the weapon fired from a bench rest by a marksman.Crown Copyright(?) 2019 Production and hosting by Elsevier B.V.on behalf of China Ordnance Society. 展开更多
关键词 aiming error RIFLE POSITION Range DISPERSION
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Structural and Electronic Properties of Cyclic Peptide-gold Nanoparticle as a Drug Delivery System 被引量:1
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作者 KHOSHBAYAN Bahareh MORSALI Ali BOZORGMEHR Mohammad Reza 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2019年第4期566-580,共15页
Using Au6 cluster and cyclooctaglycine model for gold nanoparticle(AuNP) and cyclic peptide(CP), twelve configurations for the functionalization of cyclic peptide-gold nanoparticle(CPAuNP) with gemcitabine(GEM) antica... Using Au6 cluster and cyclooctaglycine model for gold nanoparticle(AuNP) and cyclic peptide(CP), twelve configurations for the functionalization of cyclic peptide-gold nanoparticle(CPAuNP) with gemcitabine(GEM) anticancer drug were investigated(CPAuNP/GEM1-12). Structural and electronic properties have been studied in gas phase and aqueous solution at M06-2 X/6-31 g(d,p). The energetic stability of CPAuNP/GEM1-12 was confirmed by the calculation of binding energies. Since the solubility of drug, CP and AuNP increases in CPAuNP/GEM1-12, cyclic peptide-gold nanoparticle could be used as an appropriate drug delivery system. Quantum molecular descriptors such as electrophilicity power and global hardness demonstrated that the reactivity of CP and GEM drug increases in CPAuNP/GEM1-12 configurations. The AIM analysis for CPAuNP/GEM1-12 indicated that the Au-L(L = H, O, F, C, N) interactions and intermolecular hydrogen bonds play important roles in this drug delivery system. All Au-Au and some of Au-L interactions are related to medium interactions. The most stable configurations are those in which GEM drug is parallel to the CPAuNP and interacts simultaneously with AuNP and CP. 展开更多
关键词 gold NANOPARTICLE GEMCITABINE CYCLIC PEPTIDE AIM analysis NANOCARRIER
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China Aiming at Capacity Cooperation Worldwide 被引量:1
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作者 Wang Lili 《China's Foreign Trade》 2016年第6期14-15,共2页
At present,global industrial structure adjustment accelerates,infrastructure construction is still booming,and developing countries are vigorously promoting the industrialization and urbanization,all providing great o... At present,global industrial structure adjustment accelerates,infrastructure construction is still booming,and developing countries are vigorously promoting the industrialization and urbanization,all providing great opportunities for international cooperation on capacity and equipment manufacturing.In May 2015,the'Guiding Opinions of the State Council of the Peoples Republic of China on Promoting 展开更多
关键词 THAN MORE China aiming at Capacity Cooperation Worldwide
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Head Motion Detection in Gaze Based Aiming
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作者 Minghe Cao Jianzhong Wang 《Journal of Beijing Institute of Technology》 EI CAS 2020年第1期9-15,共7页
Unmanned weapons have great potential to be widely used in future wars.The gaze-based aiming technology can be applied to control pan-tilt weapon systems remotely with high precision and efficiency.Gaze direction is r... Unmanned weapons have great potential to be widely used in future wars.The gaze-based aiming technology can be applied to control pan-tilt weapon systems remotely with high precision and efficiency.Gaze direction is related to head motion,which is a combination of head and eye movements.In this paper,a head motion detection method is proposed,which is based on the fusion of inertial and vision information.The inertial sensors can measure rotation in high-frequency with good performance,while vision sensors are able to eliminate drifts.By combining the characteristics of both sensors,the proposed approach achieves the effect of highfrequency,real-time,and drift-free head motion detection.The experiments show that our method can smooth the outputs,constrain drifts of inertial measurements,and achieve high detection accuracy. 展开更多
关键词 GAZE aiming HEAD MOTION DETECTION visual-inertial information FUSION
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Matching Investigation between Instrument Precision and Aiming Method
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作者 WANG Jin jiang, JIN Guang yong, JIN Su kun, YANG Zhi wen (Graduates Dept., Changchun Institutes of Optics and Fine Mechanics, Changchun 130022, CHN) 《Semiconductor Photonics and Technology》 CAS 2002年第3期190-192,共3页
In the course of using precise visual instrument, aiming precision is an important parameter to analyze the measurement error. Usually, instrument calibrated error is set down as measurement error. In the paper, the p... In the course of using precise visual instrument, aiming precision is an important parameter to analyze the measurement error. Usually, instrument calibrated error is set down as measurement error. In the paper, the precision theory of TC2003 theodolite is analyzed and some aiming experiments is done for different width line. Then, the relations between the width of line and aiming precision are shown by different aiming methods of two superposition solid lines and one line clipped by double lines. Finally, an effective method to improve aiming precision is proposed which adopts the aiming method of one line clipped by double lines. 展开更多
关键词 aiming PRECISION MATCHING Theodoite
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AIMS(Advanced Integrity Management System)UNIX主机系统安全运行的保障
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《计算机系统应用》 北大核心 2004年第1期78-78,共1页
随着银行、电信、邮政等行业的运营日趋集中化,信息安全在各行各业中都成为重中之重。目前市场上常见的安全产品主要集中在三个领域:传输安全(SSL加密、CA认证、PKI公钥等)、物理安全(双机热备、远程灾备等)和网络安全(入侵检测、... 随着银行、电信、邮政等行业的运营日趋集中化,信息安全在各行各业中都成为重中之重。目前市场上常见的安全产品主要集中在三个领域:传输安全(SSL加密、CA认证、PKI公钥等)、物理安全(双机热备、远程灾备等)和网络安全(入侵检测、漏洞扫描、VPN、防火墙、防病毒等)。先进完整性管理系统通过集中创建生产主机环境的数据基准线,集中监控生产主机的系统环境和应用环境,保障生产环境的系统完整性,为变更管理、运营维护、降低攻击危害和安全审计方面提供了整体解决方案。一、.. 展开更多
关键词 AIMS 信息安全 UNIX 主机系统 安全运行
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布鲁氏菌与宿主天然免疫信号通路相互作用的研究进展 被引量:3
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作者 刘爱军 黄晓兵 +1 位作者 张传亮 张红丽 《畜牧兽医学报》 北大核心 2025年第4期1561-1574,共14页
布鲁氏菌病(brucellosis)是一种由布鲁氏菌(Brucella)感染引起的全球性人兽共患病。近年来,我国布鲁氏菌病防控形势严峻,对牛羊养殖业和公共卫生安全构成较大威胁。天然免疫是抵御病原微生物感染的第一道防线,对维持机体的稳态至关重要... 布鲁氏菌病(brucellosis)是一种由布鲁氏菌(Brucella)感染引起的全球性人兽共患病。近年来,我国布鲁氏菌病防控形势严峻,对牛羊养殖业和公共卫生安全构成较大威胁。天然免疫是抵御病原微生物感染的第一道防线,对维持机体的稳态至关重要。布鲁氏菌能够通过多种策略调节天然免疫信号通路,从而建立持续性感染,也能引起关节炎、肝炎、脑炎、流产等炎症性疾病。全面深入理解布鲁氏菌与天然免疫信号通路相互作用机制,可以为研发安全高效的疫苗或药物提供新的思路。因此,本文综述了Toll样受体(Toll-like receptors, TLRs)、环鸟苷酸腺苷酸合成酶(cyclic guanosine adenylate synthetase, cGAS)、干扰素基因刺激因子(stimulator of interferon genes, STING)、NOD样受体(NOD-like receptors, NLRs)、AIM2样受体(AIM2-like receptors, ALRs)、C型凝集素受体(C-type lectin receptors, CLRs)和RIG-I样受体(RIG-I-like receptors, RLRs)等天然免疫信号通路在抵御布鲁氏菌感染中的作用及机制,并总结了布鲁氏菌逃逸或劫持这些信号通路的策略。 展开更多
关键词 布鲁氏菌 免疫逃逸 Toll样受体 环鸟苷酸腺苷酸合成酶 干扰素基因刺激因子 NOD样受体 AIM2样受体 C型凝集素受体 RIG-I样受体
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A Review of the Study on the Rural Minimum Living Security System
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作者 LIU Yanjun 《International English Education Research》 2017年第4期85-88,共4页
The rural minimum living security system has the function ofguaranteeing the basic right of life, maintaining social stability and promoting social fairness. In the course of practice, the minimum living guarantee sys... The rural minimum living security system has the function ofguaranteeing the basic right of life, maintaining social stability and promoting social fairness. In the course of practice, the minimum living guarantee system has also created the problem that hinders its normal function, This paper, based on the rural subsistence allowances policy itself, the implementation of the main body, the object, the system of social environment and other aspects of the operation of rural subsistence allowances in recent years, the problems and causes of the study carried out, and on this basis, Rural low subsistence allowances research and development direction of the future, with a view to the rural minimum living system of further theoretical research, the specific practice to provide reference. 展开更多
关键词 Rural minimum living security system aiming for errors Rural minimum living standard
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Aiming at World Cup Excelling in World Cup
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《中国经贸》 2002年第1期111-112,共2页
China's entry into the WTO means that Chinese enterprises stepped onto the "big competition arena of WTO". Accession to the WTO brought fierce challenge to all Chinese enterprises. For some enterprises, ... China's entry into the WTO means that Chinese enterprises stepped onto the "big competition arena of WTO". Accession to the WTO brought fierce challenge to all Chinese enterprises. For some enterprises, it is even a crisis; but on the other hand, it provides us broader markets and more developing opportunities. Whether challenge or opportunities. the key is how we shall cope with them. Just like a sword. advantages or disadvantages depend whether it's on the edge or handle that we are holding. Perhaps s... 展开更多
关键词 World aiming at World Cup Excelling in World Cup
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Mudanjiang: Aiming at a Modern International Trade and Tourist City
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《China Today》 2001年第5期77-77,共1页
关键词 aiming at a Modern International Trade and Tourist City Mudanjiang
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China's HN-5A Air Defense Missile System
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作者 Zeng Qingbin 《Aerospace China》 1993年第1期29-32,共4页
This paper describes the HN-5Aman-portable air defense missilesystem which contains the HN-5Aweapon,test equipment and train-ing simulator.Compared with simi-lar missiles,it has more powerfulwarhead,its seeker reticle... This paper describes the HN-5Aman-portable air defense missilesystem which contains the HN-5Aweapon,test equipment and train-ing simulator.Compared with simi-lar missiles,it has more powerfulwarhead,its seeker reticle is coatedwith optical filter film,and its de-tector is equipped with cooling de-vices.Moreover,the paper alsopoints out the trends of the im-provement and development of HN-5A system. 展开更多
关键词 PORTABLE MISSILE DEFENSE SIMULATOR TRAIN instrument ENGAGE fitted aiming instead
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Quaternion Realization of Mobile Weapon Aiming Stabilization
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作者 Karol Dobrovodský Pavel Andris 《Journal of Mechanics Engineering and Automation》 2022年第1期15-22,共8页
Quaternion realization of aiming stabilization of the mobile weapon is considered.Gyro compassing combined with an inclinometer is used for the measurement of the initial chassis orientation in respect of the geograph... Quaternion realization of aiming stabilization of the mobile weapon is considered.Gyro compassing combined with an inclinometer is used for the measurement of the initial chassis orientation in respect of the geographical north and the horizontal plane.The same 3D gyroscope is used for the measurement of the subsequent incremental change of the chassis orientation.The goal of the proposed stabilization is to maintain the aiming geo coordinates generated by the fire control system while moving in an uneven terrain. 展开更多
关键词 QUATERNIONS aiming stabilization gyro compassing INCLINOMETER Earth rotation compensation
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Institute of Policy and Management: Aiming at the Ranks of World-class Think Tanks
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《Bulletin of the Chinese Academy of Sciences》 2002年第2期114-117,共4页
  Established on June 26, 1986 by the consolidation of four former CAS subordinates (namely,the Office of Policy Research, Division of Management Science, Editorial Department of the Journal of Dialectics of Nature,...   Established on June 26, 1986 by the consolidation of four former CAS subordinates (namely,the Office of Policy Research, Division of Management Science, Editorial Department of the Journal of Dialectics of Nature, and Section of Optimization and Overall Planning under the CAS Institute of Applied Mathematics), the Institute of Policy and Management (IPM), CAS, is characterized by interdisciplinary studies of social and natural sciences. It applies itself to theoretical, methodological and applied research into national strategies, policies and management for S&T development. It also provides consultancy services for government departments, local authorities and CAS on issues concerning S&T development, social and economic growth, S&T management and administration of enterprises.…… 展开更多
关键词 Institute of Policy and Management IPM aiming at the Ranks of World-class Think Tanks CAS World
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基于单滤波器AIME的GNSS/INS紧组合完好性监测
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作者 孙淑光 王添光 刘瑞华 《航空科学技术》 2025年第7期49-56,共8页
完好性是衡量导航性能的重要指标,其关键在于完好性监测算法。针对自主完好性监测外推(AIME)算法需要构建并行分级滤波器实现故障检测与排除(FDE),导致结构复杂、计算量过大的缺点。为了解决这一缺陷,本文提出一种基于不同可见星检验统... 完好性是衡量导航性能的重要指标,其关键在于完好性监测算法。针对自主完好性监测外推(AIME)算法需要构建并行分级滤波器实现故障检测与排除(FDE),导致结构复杂、计算量过大的缺点。为了解决这一缺陷,本文提出一种基于不同可见星检验统计量的单滤波器AIME(SFAIME)算法,对全球卫星导航系统(GNSS)/惯性导航系统(INS)紧组合导航系统进行完好性监测。仿真结果表明,当可见星发生斜坡故障后,SFAIME算法能够有效执行FDE,且相较于AIME算法,处理单星故障的运行时间缩短40%以上,处理双星故障的运行时间缩短90.7%以上。可见星数目越多,SFAIME算法处理速度的优势越显著。 展开更多
关键词 GNSS/INS紧组合 故障检测与排除 AIME SFAIME 斜坡故障
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应用型高校数智行政管理人才培养模式创新研究
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作者 胡联升 《海峡科学》 2025年第8期161-167,共7页
随着组织运营管理日益依赖数据驱动与智能系统,应用型高校亟须创新行政管理人才培养模式,打造与数智时代相适配的育人新生态。传统行政管理专业人才培养存在培养目标与社会需求不适、人才培养理念滞后、人才培养机制僵化、人才培养策略... 随着组织运营管理日益依赖数据驱动与智能系统,应用型高校亟须创新行政管理人才培养模式,打造与数智时代相适配的育人新生态。传统行政管理专业人才培养存在培养目标与社会需求不适、人才培养理念滞后、人才培养机制僵化、人才培养策略脱节等困境,难以满足数智治理时代的革命性要求。对此,基于AIMS理论框架,该文从目标(Aim)、理念(Idea)、机制(Mechanism)和策略(Strategy)等四个维度重构应用型高校数智行政管理人才培养模式,旨在为应用型高校新文科建设与数字化转型提供参考。 展开更多
关键词 AIMS理论 数智行政管理 人才培养模式 应用型高校
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人参皂苷Rg1通过抑制AIM2/NLRP3炎症小体改善小鼠心肌慢性炎症损伤及纤维化
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作者 樊嫘 朱幸 +3 位作者 梁浩宇 黄蕾 李卫平 李维祖 《中国药理学通报》 北大核心 2025年第12期2246-2252,共7页
目的研究人参皂苷Rg1对慢性脂多糖(lipopolysaccharide,LPS)暴露引起的小鼠心肌炎症损伤及纤维化的保护作用及其机制。方法建立慢性LPS暴露小鼠模型,随机分为对照组、LPS(200μg·kg^(-1))组、Rg1(5、10、20 mg·kg^(-1))组和Te... 目的研究人参皂苷Rg1对慢性脂多糖(lipopolysaccharide,LPS)暴露引起的小鼠心肌炎症损伤及纤维化的保护作用及其机制。方法建立慢性LPS暴露小鼠模型,随机分为对照组、LPS(200μg·kg^(-1))组、Rg1(5、10、20 mg·kg^(-1))组和Tempol(50 mg·kg^(-1))组。采用超声心动图评估心功能;HE染色、Masson染色和PAS染色观察心肌组织病理学改变;Western blot检测TRPC6、AIM2、NLRP3、cleaved caspase-1、IL-1β、IL-6和ASC蛋白表达。结果与对照组相比,LPS组小鼠心功能明显下降,心肌损伤和纤维化程度加重,TRPC6、AIM2、NLRP3、IL-1β及IL-6表达增加。与模型组比较,Rg1给药明显改善了小鼠心功能,减轻了心肌损伤和纤维化,抑制了TRPC6表达,以及AIM2/NLRP3炎症小体激活、炎症因子表达。结论Rg1可通过下调TRPC6表达,抑制AIM2/NLRP3炎症小体激活,从而减轻慢性LPS暴露引起的心肌慢性炎症损伤和纤维化。 展开更多
关键词 人参皂苷RG1 AIM2炎症小体 NLRP3炎症小体 心肌纤维化 脂多糖 TRPC6 慢性炎症
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藁本内酯通过AIM2/caspase-1信号通路抑制炎症反应改善远端大脑中动脉闭塞小鼠髓鞘脱失
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作者 梁亚杰 刘健 +7 位作者 陈莹 张紫薇 蒲萌 汤亿彬 张海飞 宋国斌 马存根 王青 《中国药理学通报》 北大核心 2025年第5期851-860,共10页
目的探讨藁本内酯(ligustilide,LIG)通过AIM2/caspase-1信号通路抑制小鼠远端大脑中动脉闭塞(distal middle cerebral artery occlusion,dMCAO)模型的炎症反应而改善髓鞘脱失的机制研究。方法将30只C57BL/6N雄性小鼠随机分为3组:假手术... 目的探讨藁本内酯(ligustilide,LIG)通过AIM2/caspase-1信号通路抑制小鼠远端大脑中动脉闭塞(distal middle cerebral artery occlusion,dMCAO)模型的炎症反应而改善髓鞘脱失的机制研究。方法将30只C57BL/6N雄性小鼠随机分为3组:假手术组(Sham组,n=10)、模型组(dMCAO组,n=10)和治疗组(LIG组,n=10)。dMCAO组和LIG组通过电凝法复制dMCAO小鼠模型,小鼠在清醒后进行Longa评分,评分2~3分为造模成功,激光散斑血流成像系统监测小鼠dMCAO术后大脑血流改变状况;造模1 h后LIG组腹腔注射LIG(30 mg·kg^(-1)·d^(-1)),Sham组和dMCAO组注射等量生理盐水,累计1周至实验结束。TTC染色观察小鼠大脑的损伤情况;采用疲劳转棒实验、旷场实验评价小鼠的运动功能以及焦虑程度;后取小鼠脑组织进行黑金染色比较各组髓鞘变化情况;采用免疫荧光染色检测各组小鼠脑内CC区、CPU区和CX区的MBP、IBA1、GFAP的平均荧光强度;采用ELISA法检测小鼠脑组织蛋白中TNF-α、IL-6、IL-1β、IL-17A和BDNF的含量;采用Western blot法检测各组AIM2、caspase-1、ASC的蛋白表达水平。结果与dMCAO组比较,LIG组小鼠梗死面积减少,行为学明显改善,且髓鞘脱失减少。脑组织中CC区、CPU区和CX区中MBP蛋白表达水平升高(P<0.05);CX区的IBA1的蛋白表达水平降低(P<0.01),CC区、CPU区和CX区中GFAP的表达水平升高(P<0.01)。ELISA结果显示,用药后TNF-α(P<0.01)、IL-6(P<0.01)、IL-1β(P<0.05)、IL-17A(P<0.01)水平明显降低,BDNF的表达水平增高(P<0.05),且用药后小鼠脑内AIM2、caspase-1、ASC的蛋白表达水平降低(P<0.01)。结论LIG对dMCAO小鼠模型的髓鞘脱失具有保护作用,其机制可能与抑制AIM2/caspase-1信号通路而抑制了炎症反应、促进星性胶质细胞表达BDNF有关。 展开更多
关键词 藁本内酯 脱髓鞘 炎性反应 dMCAO 小胶质细胞 AIM2/caspase-1信号通路
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芪黄健脾滋肾颗粒通过AIM2/Blimp-1/Bcl-6轴抑制B细胞分化改善MRL/lpr小鼠肾损害
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作者 程丽丽 汤忠富 +4 位作者 李明 陈君洁 尚双双 刘思娣 黄传兵 《南方医科大学学报》 北大核心 2025年第11期2297-2308,共12页
目的 分析芪黄健脾滋肾颗粒(QJZ)抑制MRL/lpr小鼠肾B细胞分化的疗效并探讨其潜在机制。方法 30只8周龄雌性MRL/lpr小鼠随机分为5组:模型组、QJZ组、泼尼松(Pred)组、QJZ+Pred组、黑素瘤缺乏因子2(AIM2)抑制剂组,6只/组,8周龄雌性C57BL/... 目的 分析芪黄健脾滋肾颗粒(QJZ)抑制MRL/lpr小鼠肾B细胞分化的疗效并探讨其潜在机制。方法 30只8周龄雌性MRL/lpr小鼠随机分为5组:模型组、QJZ组、泼尼松(Pred)组、QJZ+Pred组、黑素瘤缺乏因子2(AIM2)抑制剂组,6只/组,8周龄雌性C57BL/6小鼠为正常组,各组按相应方法连续处理8周。采用生化仪检测尿液尿总蛋白/尿肌酐(TPCR)、尿白蛋白/尿肌酐(ACR)及血清中肌酐(Scr)、尿素氮(BUN)水平;组织病理学染色(HE、Masson、过碘酸-雪夫)观察小鼠肾脏病理结构的变化;电镜观察肾脏超微结构变化;酶联免疫吸附测定抗dsDNA、细胞因子、趋化因子的变化;免疫组化观察肾脏中补体C3、C4沉积情况;免疫荧光观察肾脏中AIM2、CD19、CD27、CD138表达情况;流式细胞术分析脾脏B淋巴细胞亚群的变化,Western blotting检测B淋巴细胞诱导成熟蛋白1(Blimp-1)/B细胞淋巴瘤6蛋白(Bcl-6)信号轴的影响。结果 QJZ改善了MRL/lpr小鼠的Cr、BUN、TPCR、ACR水平(P<0.05),并改善肾脏的病理变化,降低抗双链DNA抗体(ds-DNA)、B细胞活化因子(BAFF)、白细胞介素(IL)-21、CXC趋化因子受体(CXCR)-12、CXCR-19、C3、C4表达,提高IL-10水平(P<0.05);Western blotting结果显示QJZ降低B细胞关键转录蛋白Blimp-1、X-box结合蛋白1(XBP-1)的表达,升高Bcl-6、配对盒5(PAX5)的表达(P<0.05);流式细胞术结果显示QJZ影响B细胞的分化,免疫荧光结果显示QJZ可降低AIM2、CD27、CD138、CD69的表达。AIM2抑制可降低B细胞关键转录蛋白Blimp-1、XBP-1的表达,升高Bcl-6、PAX5的表达(P<0.05),抑制B细胞的分化,减少IgG生成,减少C3、C4的沉积,改善肾脏的病理变化。结论 QJZ可能通过抑制AIM2/Blimp-1/Bcl-6信号通路影响B细胞分化抑制系统性红斑狼疮肾损害。 展开更多
关键词 芪黄健脾滋肾颗粒 系统性红斑狼疮 肾损害 B细胞 AIM2/Blimp-1/Bcl-6
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基于2007—2014年AIM卫星观测数据的夜光云反照率、冰水含量和中层顶温度的相关性分析
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作者 刘晓歌 王翔 刘祎 《电波科学学报》 北大核心 2025年第5期880-891,共12页
本文通过中层大气高空冰探测器(Aeronomy of Ice in the Mesosphere,AIM)卫星的仪器载荷——用于云成像和粒子实验的探测器(Cloud Imaging and Particle Size,CIPS)和用于冰晶实验的太阳掩星探测器(Solar Occultation for Ice Experimen... 本文通过中层大气高空冰探测器(Aeronomy of Ice in the Mesosphere,AIM)卫星的仪器载荷——用于云成像和粒子实验的探测器(Cloud Imaging and Particle Size,CIPS)和用于冰晶实验的太阳掩星探测器(Solar Occultation for Ice Experiment,SOFIE)在2007—2014年间南、北半球的观测数据,分析了2007—2014年间夜光云的反照率、冰水含量(ice water content,IWC)、每日发生率及中层顶温度在南、北半球的变化趋势,讨论了夜光云发生位置和年变化,并且对夜光云反照率、中层顶温度和IWC的相关性进行了分析。结果表明:南、北半球夜光云主要发生在80°~85°纬度范围内,与南半球相比,北半球夜光云反照率持续时间更长、年波动更小、IWC更高且每日发生率更高,而南半球90°W~150°W位置的反照率总是较低;南、北半球夜光云反照率和IWC均与中层顶温度之间存在负相关关系,但反照率和冰水含量相关性表现不明显。本文的研究结果为夜光云作为中间层大气变化的敏感指标提供了量化依据;同时,南、北半球夜光云的差异特性有助于改进气候模型,对理解长期气候变化中的半球不对称响应具有参考意义。 展开更多
关键词 夜光云(NLCs) 中层大气高空冰探测器(AIM) 反照率 冰水含量(IWC) 相关性
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4′-O-甲基补骨脂查尔酮经EPO/Nrf2/HO-1通路调节神经炎症改善血管性认知障碍的作用机制研究
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作者 张欣渊 汪晨 +5 位作者 陈洪庆 曾祥兵 王俊杰 张庆光 许锦文 凌霜 《中国中药杂志》 北大核心 2025年第14期3990-4002,共13页
该研究旨在探讨补骨脂有效成分4′-O-甲基补骨脂查尔酮(MeBavaC)调节脑白质神经炎症改善血管性认知障碍的作用及机制。雄性SD大鼠随机分为假手术组,模型组,MeBavaC高、低剂量组(14、7 mg·kg^(-1))。双侧颈总动脉闭塞法建立大鼠慢... 该研究旨在探讨补骨脂有效成分4′-O-甲基补骨脂查尔酮(MeBavaC)调节脑白质神经炎症改善血管性认知障碍的作用及机制。雄性SD大鼠随机分为假手术组,模型组,MeBavaC高、低剂量组(14、7 mg·kg^(-1))。双侧颈总动脉闭塞法建立大鼠慢性脑低灌注(CCH)模型。Morris水迷宫实验检测各组大鼠的学习和记忆能力;固蓝染色、尼氏染色、免疫荧光、免疫组化、透射电镜等方法观察各组大鼠白质髓鞘形态和超微结构、轴突完整性、海马神经元形态和数量、脑白质神经胶质细胞丢失和活化情况;运用转录组分析慢性脑低灌注引起白质损伤的可能机制;Western blot和qRT-PCR实验检测大鼠白质中核苷酸结合寡聚化结构域(NOD)样受体热蛋白结构域相关蛋白3(NLRP3)、黑色素瘤缺乏因子2(AIM2)、gasdermin D(GSDMD)、含半胱氨酸的天冬氨酸蛋白水解酶-1(caspase-1)、白细胞介素-18(IL-18)、白细胞介素-1β(IL-1β)、促红细胞生成素(EPO)、核因子-红细胞2相关因子2(Nrf2)、血红素氧合酶1(HO-1)的表达。结果显示,与模型组相比,MeBavaC能显著提高CCH大鼠的学习和记忆能力;改善其脑白质髓鞘损伤,维持轴突完整性;减少海马神经元和白质少突胶质细胞丢失;抑制白质小胶质细胞的活化及星形胶质细胞的增生;同时,抑制NLRP3/AIM2/caspase-1/GSDMD通路;显著降低炎症因子IL-1β和IL-18的表达;升高EPO表达和抗氧化通路Nrf2/HO-1表达。综上所述,MeBavaC能够减轻CCH大鼠的认知损伤,抑制脑白质神经炎症,其作用机制可能是通过激活EPO活性,促进内源性抗氧化通路,进而抑制脑白质神经炎症。该研究提示MeBavaC具有抗氧化和抑制神经炎症的作用,在改善认知功能障碍方面具有潜在的应用价值。 展开更多
关键词 血管性认知障碍 4′-O-甲基补骨脂查尔酮 神经炎症 白质病变 NLRP3/AIM2/caspase-1/GSDMD Nrf2/HO-1
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