Extracellular vesicles(EVs)are essential for host–pathogen interactions,mediating processes such as immune modulation and pathogen survival.Pathogen-derived EVs hold significant diagnostic potential because of their ...Extracellular vesicles(EVs)are essential for host–pathogen interactions,mediating processes such as immune modulation and pathogen survival.Pathogen-derived EVs hold significant diagnostic potential because of their unique cargo,offering a wealth of potential biomarkers.In this review,we first discuss the roles of EVs derived from various pathogens in host–pathogen interactions and summarize the latest advancements in pathogen detection based on EVs.Then,we highlight innovative strategies,including novel aggregate materials and machine learning approaches,for enhancing EV detection and analysis.Finally,we discuss challenges in the field and future directions for advancing EV-based diagnostics,aiming to translate these insights into clinical applications.展开更多
Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may ...Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may exacerbate these limitations.To address these issues,this study introduced a novel cement-stabilized permeable recycled aggregate material.A total of 162 beam specimens prepared with nine different levels of cement-aggregate ratio were tested to evaluate their permeability,bending load,and bending fatigue life.The experimental results indicate that increasing the content of recycled aggregates led to a reduction in both permeability and bending load.Additionally,the inclusion of recycled aggregates diminished the energy dissipation capacity of the specimens.These findings were used to establish a robust relationship between the initial damage in cement-stabilized permeable recycled aggregate material specimens and their fatigue life,and to propose a predictive model for their fatigue performance.Further,a method for assessing fatigue damage based on the evolution of fatigue-induced strain and energy dissipation was developed.The findings of this study provide valuable insights into the mechanical behavior and fatigue performance of cement-stabilized permeable recycled aggregate materials,offering guidance for the design of low-carbon-emission,permeable,and durable roadways incorporating recycled aggregates.展开更多
The influence of air-cooled blast furnace slag aggregates as replacement of natural aggregates on the water absorption of concrete and mortar was studied, and the mechanism was analyzed. The interface between aggregat...The influence of air-cooled blast furnace slag aggregates as replacement of natural aggregates on the water absorption of concrete and mortar was studied, and the mechanism was analyzed. The interface between aggregate and matrix in concrete was analyzed by using a micro-hardness tester, a laser confocal microscope and a scanning electron microscope with backscattered electron image mode. The pore structure of mortar matrixes under different curing conditions was investigated by mercury intrusion porosimetry. The results showed that when natural aggregates were replaced with air-cooled blast furnace slag aggregates in mortar or concrete, the content of the capillary pore in the mortar matrix was reduced and the interfacial structure between aggregate and matrix was improved, resulting in the lower water absorption of mortar or concrete. Compared to the concrete made with crushed limestone and natural river sand, the initial absorption coefficient, the secondary absorption coefficient and the water absorption capacity through the surface for 7 d of the concrete made from crushed air-cooled blast furnace slag and air-cooled blast furnace slag sand were reduced by 48.9%, 52.8%, and 46.5%, respectively.展开更多
Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differ...Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differential scanning calorimetry experiments（DSC）, etc. It was found that these compounds exhibited aggregation-induced emission phenomenon. Moreover, these target compounds displayed reversible color change from yellow to orange upon pressing and annealing process. Interestingly, all of BNAs obviously presented red-shifted piezofluorochromic（PFC） properties and behaved mainly length dependence of alkoxy group, in which, BNA displayed the largest PFC spectral shift（DlPFC= 26 nm）. The PXRD profiles demonstrated the transformation from crystalline to amorphous state upon grinding, and the mechanism of PFC behaviors was proposed. Thus, changing the length of alkoxyl chain could be an alternative way to tune their PFC behaviors.展开更多
A number of geotechnical analyses were carried out on selected carbonate rock samples from eight sites located in Egypt. This analysis was to assess the suitability of these rocks for building construction aggregate. ...A number of geotechnical analyses were carried out on selected carbonate rock samples from eight sites located in Egypt. This analysis was to assess the suitability of these rocks for building construction aggregate. The analyses included properties of uniaxial compressive strength, tensile strength, porosity, water absorption, and dynamic fragmentation. The success of building construction depends to a large extent on the availability of raw materials at affordable prices. Raw materials commonly used in the building industry include sands, gravels, clays and clay-derived products. Despite the widespread occurrence of carbonate rocks throughout Egypt, the low premium placed on their direct application in the building sector may be explained in two ways: firstly, the lack of awareness of the potential uses of carbonate rocks in the building construction industry(beyond the production of asbestos, ceiling boards, roof sheets and Portland cement); and secondly, the aesthetic application of carbonate rocks in the building construction depends mainly on their physical attributes, a knowledge of which is generally restricted to within the confines of research laboratories and industries. Thus this paper addresses the physical and mechanical characteristics of some Egyptian carbonate rocks, evaluating them for their suitability as building construction aggregates.展开更多
基金supported by National Cancer Institute grant U01CA252965Eunice Kennedy Shriver National Institute of Child Health and Human Development grants R01HD090927 and R01HD103511+1 种基金National Institute of Allergy and Infectious Diseases grants R01AI144168,R01AI175618,R01AI173021,and R01AI177986National Institute of Neurological Disorders and Stroke R21NS130542.
文摘Extracellular vesicles(EVs)are essential for host–pathogen interactions,mediating processes such as immune modulation and pathogen survival.Pathogen-derived EVs hold significant diagnostic potential because of their unique cargo,offering a wealth of potential biomarkers.In this review,we first discuss the roles of EVs derived from various pathogens in host–pathogen interactions and summarize the latest advancements in pathogen detection based on EVs.Then,we highlight innovative strategies,including novel aggregate materials and machine learning approaches,for enhancing EV detection and analysis.Finally,we discuss challenges in the field and future directions for advancing EV-based diagnostics,aiming to translate these insights into clinical applications.
基金Project(2024JJ2073)supported by the Science Fund for Distinguished Young Scholars of Hunan Province,ChinaProjects(2023YFC3807205,2019YFC1904704)+4 种基金supported by the National Key R&D Program of ChinaProject(52178443)supported by the National Natural Science Foundation of ChinaProject(2024ZZTS0109)supported by Fundamental Research Funds for the Central Universities of Central South University,China。
文摘Permeable roads generally exhibit inferior mechanical properties and shorter service life than traditional dense-graded/impermeable roads.Furthermore,the incorporation of recycled aggregates in their construction may exacerbate these limitations.To address these issues,this study introduced a novel cement-stabilized permeable recycled aggregate material.A total of 162 beam specimens prepared with nine different levels of cement-aggregate ratio were tested to evaluate their permeability,bending load,and bending fatigue life.The experimental results indicate that increasing the content of recycled aggregates led to a reduction in both permeability and bending load.Additionally,the inclusion of recycled aggregates diminished the energy dissipation capacity of the specimens.These findings were used to establish a robust relationship between the initial damage in cement-stabilized permeable recycled aggregate material specimens and their fatigue life,and to propose a predictive model for their fatigue performance.Further,a method for assessing fatigue damage based on the evolution of fatigue-induced strain and energy dissipation was developed.The findings of this study provide valuable insights into the mechanical behavior and fatigue performance of cement-stabilized permeable recycled aggregate materials,offering guidance for the design of low-carbon-emission,permeable,and durable roadways incorporating recycled aggregates.
基金Funded by the National Natural Science Foundation of China(Nos.51778003 and 51308004)the Project of Anhui Provincial Education Department for Sending Visiting Scholars to Research Abroad(No.gxfx ZD2016134)+1 种基金the Anhui Province Higher Education Revitalization Program Talent Project([2014]No.11)the National Key Research and Development Plan(No.2017YFB0310001)
文摘The influence of air-cooled blast furnace slag aggregates as replacement of natural aggregates on the water absorption of concrete and mortar was studied, and the mechanism was analyzed. The interface between aggregate and matrix in concrete was analyzed by using a micro-hardness tester, a laser confocal microscope and a scanning electron microscope with backscattered electron image mode. The pore structure of mortar matrixes under different curing conditions was investigated by mercury intrusion porosimetry. The results showed that when natural aggregates were replaced with air-cooled blast furnace slag aggregates in mortar or concrete, the content of the capillary pore in the mortar matrix was reduced and the interfacial structure between aggregate and matrix was improved, resulting in the lower water absorption of mortar or concrete. Compared to the concrete made with crushed limestone and natural river sand, the initial absorption coefficient, the secondary absorption coefficient and the water absorption capacity through the surface for 7 d of the concrete made from crushed air-cooled blast furnace slag and air-cooled blast furnace slag sand were reduced by 48.9%, 52.8%, and 46.5%, respectively.
基金financial support from the National Natural Science Foundation of China(No.21576194)
文摘Four derivatives of 9,10-bis[2-（2-alkoxynaphthalen-1-yl）vinyl]anthracene（BNAs） were designed,successfully synthesized and characterized by spectrofluorometer, powder wide-angle X-ray diffraction（PXRD） and differential scanning calorimetry experiments（DSC）, etc. It was found that these compounds exhibited aggregation-induced emission phenomenon. Moreover, these target compounds displayed reversible color change from yellow to orange upon pressing and annealing process. Interestingly, all of BNAs obviously presented red-shifted piezofluorochromic（PFC） properties and behaved mainly length dependence of alkoxy group, in which, BNA displayed the largest PFC spectral shift（DlPFC= 26 nm）. The PXRD profiles demonstrated the transformation from crystalline to amorphous state upon grinding, and the mechanism of PFC behaviors was proposed. Thus, changing the length of alkoxyl chain could be an alternative way to tune their PFC behaviors.
文摘A number of geotechnical analyses were carried out on selected carbonate rock samples from eight sites located in Egypt. This analysis was to assess the suitability of these rocks for building construction aggregate. The analyses included properties of uniaxial compressive strength, tensile strength, porosity, water absorption, and dynamic fragmentation. The success of building construction depends to a large extent on the availability of raw materials at affordable prices. Raw materials commonly used in the building industry include sands, gravels, clays and clay-derived products. Despite the widespread occurrence of carbonate rocks throughout Egypt, the low premium placed on their direct application in the building sector may be explained in two ways: firstly, the lack of awareness of the potential uses of carbonate rocks in the building construction industry(beyond the production of asbestos, ceiling boards, roof sheets and Portland cement); and secondly, the aesthetic application of carbonate rocks in the building construction depends mainly on their physical attributes, a knowledge of which is generally restricted to within the confines of research laboratories and industries. Thus this paper addresses the physical and mechanical characteristics of some Egyptian carbonate rocks, evaluating them for their suitability as building construction aggregates.
