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Walking for Mental Health:Effects of Mobile-Based Walking on Stress and Affectivity in College Students
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作者 Ye Hoon Lee Juhee Hwang 《International Journal of Mental Health Promotion》 2025年第2期179-191,共13页
Objectives:Recent research has shown that college students experience high levels of stress from various sources,which contribute to heightened rates of psychological distress and make them particularly vulnerable to ... Objectives:Recent research has shown that college students experience high levels of stress from various sources,which contribute to heightened rates of psychological distress and make them particularly vulnerable to mental health issues.Hence,we conducted a study,aimed to analyze the influence of a mobile-based walking routine on mental health outcomes,such as perceived stress and positive and negative affect.Methods:The participants were divided into two groups:the walking group(N=23)and the control group(N=24).The walking group engaged in an approximately 25-min walking session for at least 3 days per week,which was carefully monitored and facilitated with the help of the Nike Run Club application.The statistical analysis of the quantitative data was carried out with the help of SPSS 25.0.In addition to calculating descriptive statistics,we conducted an independent samples t-test,a repeated-measures ANOVA,and a paired sample t-test to analyze the effectiveness of the intervention.Results:A repeated-measures ANOVA revealed that the walking group exhibited significant reductions in perceived stress(t=2.03,p=0.049,Cohen’s D=0.60)and negative affect(t=2.19,p=0.033,Cohen’s D=0.65)after the intervention,whereas the control group showed no significant changes across time in any of the proposed variables.Conclusion:The results of the study continue to be indicative of the positive effects of regular walking on perceived stress and negative affect,preserving its role as a straightforward and accessible tool for reducing stress and negative affect. 展开更多
关键词 Mental health low-intensity exercise mental health outcomes mobile intervention positive and negative affect
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青少年突发性感音神经性聋的临床特征及预后因素分析
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作者 姚丽 张烽 张卫拾 《中国耳鼻咽喉头颈外科》 2025年第5期332-334,共3页
目的 分析青少年突发性感音神经性聋(sudden sensorineural hearing loss,SSNHL)的临床特征及预后因素。方法 选取2019年9月~2023年12月南通市第三人民医院及南通市第一人民医院接受治疗且临床资料完整的80例青少年SSNHL患者,分析患者... 目的 分析青少年突发性感音神经性聋(sudden sensorineural hearing loss,SSNHL)的临床特征及预后因素。方法 选取2019年9月~2023年12月南通市第三人民医院及南通市第一人民医院接受治疗且临床资料完整的80例青少年SSNHL患者,分析患者的一般资料、临床特征、实验室检查结果、治疗及预后情况。结果 80例患者均以突发性单侧听力下降和(或)突发单侧耳鸣为主诉,72例(90.00%)伴耳鸣,40.28%伴高频耳鸣,59.72%伴低频耳鸣,55.00%伴耳闷胀感或耳周感觉异常,26例(32.50%)伴眩晕/头晕。听力损失分型以低频下降型为主(40.00%),听力损失程度以中度居多(56.25%)。实验室检查结果显示,中性粒细胞与淋巴细胞比值(NLR)>3.0者占65.00%,血小板-淋巴细胞比值(PLR)>150者占32.50%,纤维蛋白原>4.0 g/L者占43.75%。治疗后3个月随访显示,总体预后良好率为65.00%(52例),预后良好组平均听阈改善优于预后不良组(P<0.001)。7例(8.75%)在随访期间复发,其中6例为全聋型患者;2例(2.50%)出现轻度耳鸣加重。多因素Logistic回归分析表明,极重度听力损失、日均耳机使用>3 h、高频熬夜及NLR>3.0是预后不良的独立危险因素(P均<0.05)。结论 青少年SSNHL的发病与长时间使用耳机、高频熬夜及炎症-凝血异常等因素有关,极重度听力损失、不良生活习惯及炎症指标异常是预后不良的独立危险因素,提示青少年需重视听力保护,减少熬夜及噪声暴露。 展开更多
关键词 青少年(Adolescent) 听觉丧失 感音神经性(Hearing Loss Sensorineural) 听觉丧失 突发性(Hearing Loss Sudden) 预后(Prognosis) 临床特征(clinical characteristics) 影响因素(affecting factors)
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A Review of the Hydrodynamic Damping Characteristics of Blade-like Structures:Focus on the Quantitative Identification Methods and Key Influencing Parameters 被引量:1
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作者 Yongshun Zeng Zhaohui Qian +1 位作者 Jiayun Zhang Zhifeng Yao 《哈尔滨工程大学学报(英文版)》 2025年第1期21-34,共14页
Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.Howev... Ocean energy has progressively gained considerable interest due to its sufficient potential to meet the world’s energy demand,and the blade is the core component in electricity generation from the ocean current.However,the widened hydraulic excitation frequency may satisfy the blade resonance due to the time variation in the velocity and angle of attack of the ocean current,even resulting in blade fatigue and destructively interfering with grid stability.A key parameter that determines the resonance amplitude of the blade is the hydrodynamic damping ratio(HDR).However,HDR is difficult to obtain due to the complex fluid-structure interaction(FSI).Therefore,a literature review was conducted on the hydrodynamic damping characteristics of blade-like structures.The experimental and simulation methods used to identify and obtain the HDR quantitatively were described,placing emphasis on the experimental processes and simulation setups.Moreover,the accuracy and efficiency of different simulation methods were compared,and the modal work approach was recommended.The effects of key typical parameters,including flow velocity,angle of attack,gap,rotational speed,and cavitation,on the HDR were then summarized,and the suggestions on operating conditions were presented from the perspective of increasing the HDR.Subsequently,considering multiple flow parameters,several theoretical derivations and semi-empirical prediction formulas for HDR were introduced,and the accuracy and application were discussed.Based on the shortcomings of the existing research,the direction of future research was finally determined.The current work offers a clear understanding of the HDR of blade-like structures,which could improve the evaluation accuracy of flow-induced vibration in the design stage. 展开更多
关键词 Blade fatigue Hydrodynamic damping ratio Identification method Affecting factors Prediction formula
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海外英文期刊中国共产党研究成果题录(2017年)
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作者 王野(整理) 《国外理论动态》 北大核心 2025年第3期F0003-F0003,共1页
1.A.Mertha,“‘Stressing Out’:Cadre Calibration and Affective Proximity to the CCP in Reform-Era China”,The China Quarterly,Vol.229,2017,pp.64-85.2.B.L.McCormick,“Book Review of‘The Chinese Communist Party's C... 1.A.Mertha,“‘Stressing Out’:Cadre Calibration and Affective Proximity to the CCP in Reform-Era China”,The China Quarterly,Vol.229,2017,pp.64-85.2.B.L.McCormick,“Book Review of‘The Chinese Communist Party's Capacity to Rule:Ideology,Legitimacy and Party Cohesion’”,The China Journal,Vol.77,2017,pp.161-163. 展开更多
关键词 affective proximity chinese communist party party cohesion IDEOLOGY LEGITIMACY cadre calibration
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One-Dimensionality, Reliability, Distribution, and Correlates of the Brief Interactive Optimism Scale among University Teachers
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作者 José Moral de la Rubia Adrián Valle de la O Jesús Alfonso Beltran-Sanchez 《Open Journal of Medical Psychology》 2025年第1期41-70,共30页
The Brief Interactive Optimism Scale (BIOS-G), recently published, was developed to measure optimism based on the interactive personality styles theory in the general population of Mexican adults. It has been validate... The Brief Interactive Optimism Scale (BIOS-G), recently published, was developed to measure optimism based on the interactive personality styles theory in the general population of Mexican adults. It has been validated in both the general population in Mexico and other Latin American countries. This study aims to further consolidate the validity of the BIOS-G in a specific population. The objectives are to assess the psychometric properties of its items, validate its unidimensional structure, describe its distribution, verify its internal consistency, and examine its direct relationship with affective balance and positive affect, as well as its inverse relationship with emotional exhaustion and negative affect among Mexican university teachers. The BIOS-G, the CESQT emotional exhaustion subscale, and Scale of Positive and Negative Experience (SPANE) were administered to a non-probability sample of 213 Mexican university teachers. All items demonstrated discriminative power and internal consistency. The scale showed internal consistency (Green-Yang ordinal ω = 0.74 and McDonald ordinal ω = 0.88). The one-factor model presented good to acceptable fit to the data, with an average variance extracted of 0.65. Its distribution was negatively skewed and mesokurtic. The BIOS-G correlated directly with SPANE’s affective balance and positive emotional experiences and inversely with negative emotional experiences and emotional exhaustion, with moderate strengths of association. Its mean score was higher in men than in women and correlated positively with age. It is concluded that the BIOS-G demonstrates internal consistency and validity evidence among Mexican university teachers, and its use in this specific population is recommended. 展开更多
关键词 OPTIMISM Psychometric Properties Affective Balance Emotional Exhaustion University Teachers
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Leveraging CNN to Analyse Facial Expressions for Academic Engagement Monitoring with Insights from the Multi⁃Source Academic Affective Engagement Dataset
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作者 Noora C T Tamil Selvan P 《Journal of Harbin Institute of Technology(New Series)》 2025年第2期65-79,共15页
The dynamics of student engagement and emotional states significantly influence learning outcomes.Positive emotions resulting from successful task completion stand in contrast to negative affective states that arise f... The dynamics of student engagement and emotional states significantly influence learning outcomes.Positive emotions resulting from successful task completion stand in contrast to negative affective states that arise from learning struggles or failures.Effective transitions to engagement occur upon problem resolution,while unresolved issues lead to frustration and subsequent boredom.This study proposes a Convolutional Neural Networks(CNN)based approach utilizing the Multi⁃source Academic Affective Engagement Dataset(MAAED)to categorize facial expressions into boredom,confusion,frustration,and yawning.This method provides an efficient and objective way to assess student engagement by extracting features from facial images.Recognizing and addressing negative affective states,such as confusion and boredom,is fundamental in creating supportive learning environments.Through automated frame extraction and model comparison,this study demonstrates reduced loss values with improving accuracy,showcasing the effectiveness of this method in objectively evaluating student engagement.Monitoring facial engagement with CNN using the MAAED dataset is essential for gaining insights into human behaviour and improving educational experiences. 展开更多
关键词 emotion recognition student engagement facial expressions academic affective engagement MAAED
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Dying Virtually in War:The Affective Logic of Heroism in The Red Badge of Courage
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作者 Zicong Fan 《Cultural and Religious Studies》 2025年第1期42-50,共9页
For the following decades after the American Civil War,most American literature works presented the war in a romantic or sentimental manner.However,Stephen Crane’s The Red Badge of Courage gave it a naturalistic touc... For the following decades after the American Civil War,most American literature works presented the war in a romantic or sentimental manner.However,Stephen Crane’s The Red Badge of Courage gave it a naturalistic touch to tell the story of Henry Fleming,the main character,overcoming cowardice and becoming a hero.Through its revolutionary criticism of psychoanalysis and capitalism,Deleuze and Guattari contributed a legacy to postmodern philosophy with their affect philosophy,with virtuality at its pivot.Using the Deleuzo-Guattarian affective philosophy as a scope,it is clear that the maturing of Henry is in fact a sequence of two attempts of deterritorialization in the war,one failed and the other successful.The heroism Henry acquires is demonstrated in the form of virtual death and disconnection with meaning;nonetheless,his return to the society makes it an incomplete destratification,which,at the same time,indicates the opportunity to be a true hero is forever lost to Henry,lost on the battlefield. 展开更多
关键词 Stephen Crane affect theory Gilles Deleuze body without organs virtual death
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Traditional Chinese Medicine five-tone intelligent diagnosis and treatment system
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作者 ZHANG Jingzhi ZHANG Xingzhao +6 位作者 LIU Yao ZHOU Yuanzi WANG Site ZHOU Hanyu ZHU Hongguang LIN Facai XING Zhenlong 《Journal of Traditional Chinese Medicine》 2025年第3期702-710,共9页
Under the background of Artificial Intelligence(AI)and medical data informationization,intelligent Traditional Chinese Medicine(TCM)emerges as a new medical model.In this study,we introduce Affective Computing into th... Under the background of Artificial Intelligence(AI)and medical data informationization,intelligent Traditional Chinese Medicine(TCM)emerges as a new medical model.In this study,we introduce Affective Computing into the diagnosis and treatment process of TCM FiveTone Therapy.And proposes an intelligent diagnosis and treatment system including Five-tone diagnosis,monitoring and treatment,to achieve intelligent music matching.This system based on sound-image database for standardized collection and diagnosis of the Five-tone.The assessment and monitoring process are then visually presented,and an emotion analysis model is established by using affective computing.On the other hand,the system employs virtual reality(VR)visual media music and somatosensory music to play and intelligently match the Five-tone,solving issues in the clinical treatment of Five-tone therapy,such as the difficulties of quantifying emotional data,limited ability for generalization feature extraction,and relatively insufficient research on the intelligence of Five-tone therapy.This study can promote the integration of technology in the fields of healthcare,information,and music,thereby enhancing the accuracy of diagnosis and treatment.It holds significant importance in advancing the intelligent development of Traditional Chinese Medicine diagnosis and treatment. 展开更多
关键词 computer technology intelligent diagnosis and treatment affective computing music therapy Five-tone therapy Five notes
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Podzolised soils developed from slope deposits reveal relict frost features concealed by organic matter accumulation in the Stolowe Mountains(SW Poland)
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作者 Joanna Beata KOWALSKA 《Journal of Mountain Science》 2025年第8期2731-2746,共16页
Considering the comprehensive morphology and genesis of Podzols of the Stolowe Mountains,and the still-possible impact of frost actions and other processes related to cold climate on these soils,the main aims of this ... Considering the comprehensive morphology and genesis of Podzols of the Stolowe Mountains,and the still-possible impact of frost actions and other processes related to cold climate on these soils,the main aims of this study were to determine whether(i)the heterogeneous Podzols in the Stolowe Mountains underwent a phase of development in a cold climate,resulting in frost action features visible on the micromorphological level,and whether(ii)contemporary cryopedogenic traces are masked by the translocation of organic matter due to the podzolisation process.Four soil profiles were investigated,revealing distinct layers corresponding to different periods of soil formation.Under field observation,no explicit frost-related characteristics were observed.Nevertheless,micromorphological analysis revealed cappings of fine materials on grains or peds,as well as development of granostriated(or any striated)b-fabric that resulted from the alternating effects of thawing and freezing processes.Moreover,micromorphological analysis revealed the presence of microstructures that could be the result of cryogenic processes,such as platy,angular blocky and lenticular features,as well as plane,vugh and star-shaped void types.The translocation of organic matter during podzolisation modified or concealed the frost-related features that developed during the late Pleistocene and early Holocene.This is evident,for instance,in the accumulation of organic matter on cappings and within soil voids,which further hinders the identification of frost-related characteristics and the interpretation of the soil's evolution.Macromorphological observations enhanced with micromorphological analyses revealed three distinct layers:(i)a young upper layer composed of loose,sandy material;(ii)a deeper layer containing a spodic horizon with frost actions,involving pedofeatures associated with the Pleistocene cold climate and(iii)a deeper subsoil basal layer.The abovementioned microstructures,combined with lithological discontinuity,support the hypothesised polygenetic origin of Podzols in the studied region. 展开更多
关键词 Cryogenesis Frost action Frost affected microfeatures Organic matter translocation
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Construction of a Theoretical Framework for the Identification and Treatment of Affective Disorders in Traditional Chinese Medicine Based on the“Five-organ View of Unity”
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作者 Xu Yang Jiaming Shi +1 位作者 Chuanxiang Wang Jiazhuo Li 《Expert Review of Chinese Medical》 2025年第2期7-9,共3页
This paper is dedicated to constructing a theoretical framework for the identification and treatment of affective disorders in traditional Chinese medicine based on the“five-organ view”.Through in-depth analysis of ... This paper is dedicated to constructing a theoretical framework for the identification and treatment of affective disorders in traditional Chinese medicine based on the“five-organ view”.Through in-depth analysis of the theoretical connotation of the“five-organ concept”,we discussed the characteristics of the five-organ mechanism of affective-philosophical disorders in detail,systematically constructed a system of identification based on the association of the five organs,and proposed a comprehensive and holistic treatment strategy.The results of the study clearly show that the theoretical framework can provide systematic theoretical guidance for the clinical diagnosis and treatment of affective-philosophical disorders in Chinese medicine,help to improve the diagnostic and therapeutic effects of affective-philosophical disorders,and provide new ideas and methods for the theoretical development and clinical practice of affective-philosophical disorders in Chinese medicine,which is of important theoretical and practical significance,and can further promote the modernization of the development of affective-philosophical disorders in Chinese medicine. 展开更多
关键词 five-organ view affective disorder traditional Chinese medicine diagnosis and treatment
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Preliminary study on the efficacy of intermittent theta burst stimulation (iTBS) in adolescents with affective disorders, with and without antidepressants
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作者 Peiying Li Yuwei Xia +9 位作者 Xinyao Liu Shiqi Yuan Chengfeng Chen Kun Xie Wuyou Bao Shiying Wang Ru Hao Cuixia An Ling Sun Bin Zhang 《General Psychiatry》 2025年第3期220-225,共6页
To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective dis... To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%. 展开更多
关键词 major depressive disorder mdd adolescents bipolar disorder nationwide survey affective disorders intermittent theta burst stimulation antidepressants
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环境服务过度对消费者情感反应影响的探索性研究
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作者 宫翔宇 《消费与品牌传播》 2025年第6期0030-0032,共3页
消费者在服务接触过程中直接感知服务质量,其情感反应(AffectiveResponse)亦在此过程中形成,因此,服务接触对于服务行业的高质量发展具有重要意义。服务接触涵盖人员接触(PersonnelContact)与环境接触(EnvironmentalContact)两个维度。... 消费者在服务接触过程中直接感知服务质量,其情感反应(AffectiveResponse)亦在此过程中形成,因此,服务接触对于服务行业的高质量发展具有重要意义。服务接触涵盖人员接触(PersonnelContact)与环境接触(EnvironmentalContact)两个维度。现有研究主要集中在人员接触中的过度服务(Over-Service)对消费者情感的影响,而对环境接触中的过度服务如何影响消费者情感反应的研究相对较少。本文使用焦点小组(FocusGroup)和实验设计法(ExperimentalDesign),研究环境服务过度对消费者情感反应的影响,并探究消费者的最优刺激水平如何调节环境服务水平对情感反应的影响。研究表明,不同的接触环境会导致消费者不同的消费情感反应,高环境服务水平降低了消费者正面情感反应并提高了负面情感反应,消费者个人的低最优刺激水平或高最优刺激水平没有对环境服务和情感反应的关系产生影响。 展开更多
关键词 服务接触 环境接触 刺激-反应理论(S-R Theory) 情感效价(Affective Valence)
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A novel ejaculation-sparing surgical technique in the patient with primary bladder neck obstruction:Results of a single-arm cohort
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作者 Marco Dellabella Luca Gasparri +5 位作者 Antonio Vinci Massimo Maurici Redi Claudini Alessandro Branchi Michele Pucci Edoardo Agostini 《Asian Journal of Urology》 2025年第2期278-280,共3页
Dear Editor,Primary bladder neck obstruction(PBNO)affects approximately 28%–54%of men[1].Its etiology remains unclear.Symptoms of PBNO present as voiding(e.g.,decreased force of stream,hesitancy,intermittent stream,a... Dear Editor,Primary bladder neck obstruction(PBNO)affects approximately 28%–54%of men[1].Its etiology remains unclear.Symptoms of PBNO present as voiding(e.g.,decreased force of stream,hesitancy,intermittent stream,and incomplete emptying),storage(e.g.,frequency,urgency,urge incontinence,and nocturia),or a combination of both[2].Untreated PBNO can lead to bladder dysfunction,bladder diverticula,hydronephrosis,and impaired renal function[3]. 展开更多
关键词 impaired renal function ejaculation sparing surgical technique storage symptoms bladder dysfunctionbladder diverticulahydronephrosisand voiding symptoms bladder neck obstruction pbno affects primary bladder neck obstruction
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The Effect of Leader Positive Affectivity on Team Member Turnover Intention and Team Organizational Citizenship Behavior
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作者 Lynda Jiwen Song Kelly Z. Peng +1 位作者 Chi-Sum Wong Weiku Wu 《Frontiers of Business Research in China》 2013年第3期311-332,共22页
This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team le... This paper develops two models to investigate the effect of team leader positive affectivity (PA) on team member turnover intention and team organizational citizenship behavior (OCB), at the individual and team levels, respectively. A two-wave longitudinal study was conducted involving a survey of 58 team leaders and 174 team members in a large Chinese telecom company across a three-month period. We found that team members' organization-based self-esteem (OBSE) at Time 1 mediates the relationship between team leader PA at Time 1 and team member turnover intention at Time 2, whereas team aggregated OBSE at Time 1 mediates the relationship between leader PA at Time1 and team OCB at Time 2. 展开更多
关键词 positive affectivity organization-based self-esteem (OBSE) teamorganizational citizenship behavior (OCB)
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Clinical, scientific and stakeholders’ caring about identity perturbations
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作者 Henriette Löffler-Stastka 《World Journal of Psychiatry》 SCIE 2024年第10期1422-1428,共7页
In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways... In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Psychiatry.We focus on identity diffusion,identity perturbations,their origin and developmental pathways.This is an upcoming problem in the society as not only school children are affected.Adolescents and young people suffer from uncertainty in gender identity,in self-image,migration effects due to chronic crises caused by war,pandemic disruptions or climate change.We show how such chronic uncertainty can be cared for,treated,and contained.The key is affective holding,reflection and to provide adequate affective mentalizing in a close concomitant way.These key features also depend on ambient conditions,such as psychotherapeutic care.In a qualitative interview study carried out in a cyclical research design with a comparative analysis on the basis of thematic coding using Grounded Theory Methodology we found institu-tionalized defenses in health policies.Professionals request better training and adequat academic knowledge as well as research into unresolved areas for improvement of the ambient conditions for adequat development of the self.Practice points for further clinical and scientific development are given and discussed. 展开更多
关键词 Identity diffusion Trauma DISSOCIATION Ambient conditions Environment containment Mentalized affectivity
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Superior strength-ductility combination resulted from hetero-zone boundary affected region in Cu-Fe layered material 被引量:2
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作者 Hao Ran Peihao Ye +8 位作者 Fengjiao Guo Mingsai Wang Wuli Su Xue Chen Si Gao Nobuhiro Tsuji Yuntian Zhu Xiaochong Lu Chongxiang Huang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第14期209-219,共11页
The hetero-zone boundary affected region(HBAR)significantly influences the mechanical behaviors of layered materials,where the deformation mechanisms differ from those in the bulk layers.In this study,three kinds of h... The hetero-zone boundary affected region(HBAR)significantly influences the mechanical behaviors of layered materials,where the deformation mechanisms differ from those in the bulk layers.In this study,three kinds of heterogeneous Cu-Fe layered materials with different interface spacing but identical total thicknesses were prepared.The effects of HBAR and strain partitioning on the tensile behavior of the lay-ered materials were investigated.The results showed that layered materials had enhanced yield strength and uniform elongation with decreasing interface spacing.During tensile deformation,geometrically nec-essary dislocations(GNDs)were generated at hetero-zone boundaries and piled up near them,resulting in hetero-deformation induced(HDI)strengthening and HDI work hardening.Surface profilometry mea-surements showed that the Cu and Fe layers exhibited obvious strain partitioning and mutual constraint.With decreasing interface spacing,strain partitioning is enhanced by interlayer constraint,which pre-vented strain localization at interfaces and thus improved the synergetic deformation of layers.A higher fraction of HBAR can improve the mechanical performance of heterogeneous layered materials.This study deepens our understanding of the relationship between HBAR and strength-ductility synergy and provides some insight into the design of layered materials. 展开更多
关键词 Hetero-zone boundary affected region Layered material Strain partitioning Geometrically necessary dislocation Hetero-deformation
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Functional dissection of parabrachial substrates in processing nociceptive information 被引量:1
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作者 Jin Ke Wei-Cheng Lu +11 位作者 Hai-Yang Jing Shen Qian Sun-Wook Moon Guang-Fu Cui Wei-Xin Qian Xiao-Jing Che Qian Zhang Shi-Shi Lai Ling Zhang Ying-Jie Zhu Jing-Dun Xie Tian-Wen Huang 《Zoological Research》 SCIE CSCD 2024年第3期633-647,共15页
Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of sufferin... Painful stimuli elicit first-line reflexive defensive reactions and,in many cases,also evoke second-line recuperative behaviors,the latter of which reflects the sensing of tissue damage and the alleviation of suffering.The lateral parabrachial nucleus(lPBN),composed of external-(elPBN),dorsal-(dlPBN),and central/superior-subnuclei(jointly referred to as slPBN),receives sensory inputs from spinal projection neurons and plays important roles in processing affective information from external threats and body integrity disruption.However,the organizational rules of lPBN neurons that provoke diverse behaviors in response to different painful stimuli from cutaneous and deep tissues remain unclear.In this study,we used region-specific neuronal depletion or silencing approaches combined with a battery of behavioral assays to show that slPBN neurons expressing substance P receptor(NK1R)(lPBNNK1R)are crucial for driving pain-associated self-care behaviors evoked by sustained noxious thermal and mechanical stimuli applied to skin or bone/muscle,while elPBN neurons are dispensable for driving such reactions.Notably,lPBNNK1R neurons are specifically required for forming sustained somatic pain-induced negative teaching signals and aversive memory but are not necessary for fear-learning or escape behaviors elicited by external threats.Lastly,both lPBNNK1R and elPBN neurons contribute to chemical irritant-induced nocifensive reactions.Our results reveal the functional organization of parabrachial substrates that drive distinct behavioral outcomes in response to sustained pain versus external danger under physiological conditions. 展开更多
关键词 Lateral parabrachial nucleus Substance P receptor Pain affect Defensive reaction SOMATOSENSORY
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Development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements 被引量:1
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作者 Tingting Li Jian Yang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第6期1263-1284,共22页
The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles du... The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during welding.The chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact toughness.This work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input welding.Ti complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF contents.However,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually multiphase.Increasing alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF formation.Si,Cr,or Al addition leads to the formation of undesirable microstructures.Nb reduces the high-temperature stability of the precipitates.Mo,V,and B can enhance HAZ toughness.Mo-containing precipitates present good thermal stability.VN or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with ferrite.The formation of the B-depleted zone around the inclusion promotes IAF formation.The interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be evaluated.In the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of oxide metallurgy. 展开更多
关键词 oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element
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Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer 被引量:1
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作者 Zhen-Yu Ding Ying Piao +4 位作者 Tong Jiang Juan Chen Yi-Nuo Wang Hui-Ying Yu Zhen-Dong Zheng 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第10期3202-3210,共9页
BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and optimization.AIM To clarify the impact of chemotherapy plus cellular immunotherapy[de... BACKGROUND The outcome of surgical treatment for colorectal cancer(CRC)remains unsatis-factory and warrants further exploration and optimization.AIM To clarify the impact of chemotherapy plus cellular immunotherapy[dendritic cell-cytokine-induced killer(DC-CIK)cell immunotherapy]on patients after CRC surgery and to explore the mediating variables.METHODS A total cohort of 121 patients who underwent CRC surgery between January 2019 and April 2022 were selected.The sample comprised a control group of 55 pa-tients who received the XELOX chemotherapy regimen and a research group of 66 patients who received XELOX+DC-CIK immunotherapy.We performed compa-rative analyses of the clinical and pathological data of the two groups,including efficacy(2-year disease-free survival[DFS]rate),the incidence of adverse events(diarrhea,myelosuppression,gastrointestinal reactions,and peripheral neuritis),serum levels of tumor markers[carcinoembryonic antigens and carbohydrate an-tigens(CA)19-9 and CA242],and T-cell subsets[cluster of differentiation(CD)3+,CD3+CD4+,CD3+CD8+,natural killer(NK),and NK T cells].We also conducted preliminary univariate and mul-tivariate analyses of the variables that affected the efficacy of the treatments.RESULTS We found a significantly higher 2-year DFS rate of treatment efficacy in the research group than in the control group,with a statistically lower incidence of adverse events.Both groups showed a reduction in serum tumor markers after treatment but there was no marked intergroup difference.After treatment,the various T-cell subgroup indicators in the control group were significantly lower than those in the research group.The indices of T-cell subsets in the research group showed no significant change from preoperative levels.Univariate analysis revealed a significant correlation between TNM staging,tumor differentiation,and the rates of nonresponse to treatment in CRC patients after surgery.Multivariate results indicated that the treatment approach significantly affected the efficacy of postoperative CRC treatment.CONCLUSION We concluded that XELOX+DC-CIK immunotherapy for postsurgical CRC patients offers reduced rates of treatment-induced adverse events,extended 2-year DFS,enhanced immunity,and increased physiological antitumor responses. 展开更多
关键词 Analysis of variables affecting outcomes Cellular immunotherapy CHEMOTHERAPY Colorectal cancer Clinical effects
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Insights into Reservoir-Triggered Landslides Development and Its Influence Factors in the Three Gorges Reservoir Area,China
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作者 Shilin Luo Da Huang +3 位作者 Jianbing Peng Zhouzhou Xie Zhiyu Yang Roberto Tomás 《Journal of Earth Science》 SCIE CAS CSCD 2024年第6期1979-1997,共19页
More than 5000 landslides or potential landslides have been triggered in the Three Gorges Reservoir(TGR)area since the impoundment in 2003.This study aims at investigating the reservoirinduced landslides spatiotempora... More than 5000 landslides or potential landslides have been triggered in the Three Gorges Reservoir(TGR)area since the impoundment in 2003.This study aims at investigating the reservoirinduced landslides spatiotemporal and size distribution and its influence factors in the TGR by taking 790 landslides as statistical samples.The landslides exhibit significant regional and sub-regional spatial differences,and numerous landslides occurred at the initial three impoundment stages and the corresponding 2-3 cycles of reservoir operations followed,but the landslide frequency decreased dramatically after 2010 from temporal perspective.The relationship between landslide development and topographical,geological as well as hydrological factors were analyzed qualitatively.The reservoir-induced landslides in TGR area exhibit self-organized criticality and the rollover is nearly 2.5×10^(4) m^(2),which could not be attributed to the missing data but the coupled influences imposed by affecting factors.Both the double Pareto and inverse gamma functions are more suitable than the power-law function to present the landslide size characteristics.In term of the fitting precious,the adaptability of the inverse gamma function is better if the landslide inventories are limited.The research results provide foundation for the landslide susceptibility maps and hazard risk assessment. 展开更多
关键词 LANDSLIDES slope stability affecting factors Three Gorges Reservoir self-organized criticality
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