In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation anal...In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation analysis on two typical co-pollution events in Beijing,occurring from July 22 to July 28,2019,and from April 25 to May 2,2020.These events were categorized into pre-trough southerly airflow type(Type 1)and post-trough northwest flow type(Type 2).Subsequently,sensitivity analyses using the GRAPES-CUACE adjoint model were performed to quantify the contributions of precursor emissions from Beijing and surrounding areas to PM_(2.5)and O_(3) concentrations in Beijing for two types of co-pollution.The results indicated that the spatiotemporal distribution of sensitive source region varied among different circulation types.Primary PM_(2.5)(PPM_(2.5))emissions from Hebei contributed the most to the 24-hour average PM_(2.5)(24-h PM_(2.5))peak concentration(41.6%-45.4%),followed by Beijing emissions(31%-35.7%).The maximum daily 8-hour average ozone peak concentration was primarily influenced by the emissions from Hebei and Beijing,with contribution ratios respectively of 32.8%-44.8% and 29%-42.1%.Additionally,NO_(x)emissions were the main contributors in Type 1,while both NO_(x)and VOCs emissions contributed similarly in Type 2.The iterative emission reduction experiments for two types of co-pollution indicated that Type 1 required emission reductions in NO_(x)(52.4%-71.8%)and VOCs(14.1%-33.8%)only.In contrast,Type 2 required combined emission reductions in NO_(x)(37.0%-65.1%),VOCs(30.7%-56.2%),and PPM_(2.5)(31%-46.9%).This study provided a reference for controlling co-pollution events and improving air quality in Beijing.展开更多
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha...In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain.展开更多
Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(...Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].展开更多
Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying ...Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying issues with services,products,or customer experience,resulting in considerable income loss.Prediction of customer churn is a crucial task aimed at retaining customers and maintaining revenue growth.Traditional machine learning(ML)models often struggle to capture complex temporal dependencies in client behavior data.To address this,an optimized deep learning(DL)approach using a Regularized Bidirectional Long Short-Term Memory(RBiLSTM)model is proposed to mitigate overfitting and improve generalization error.The model integrates dropout,L2-regularization,and early stopping to enhance predictive accuracy while preventing over-reliance on specific patterns.Moreover,this study investigates the effect of optimization techniques on boosting the training efficiency of the developed model.Experimental results on a recent public customer churn dataset demonstrate that the trained model outperforms the traditional ML models and some other DL models,such as Long Short-Term Memory(LSTM)and Deep Neural Network(DNN),in churn prediction performance and stability.The proposed approach achieves 96.1%accuracy,compared with LSTM and DNN,which attain 94.5%and 94.1%accuracy,respectively.These results confirm that the proposed approach can be used as a valuable tool for businesses to identify at-risk consumers proactively and implement targeted retention strategies.展开更多
This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to use...This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities.展开更多
The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is m...The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples.展开更多
To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework ba...To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.展开更多
Human motion modeling is a core technology in computer animation,game development,and humancomputer interaction.In particular,generating natural and coherent in-between motion using only the initial and terminal frame...Human motion modeling is a core technology in computer animation,game development,and humancomputer interaction.In particular,generating natural and coherent in-between motion using only the initial and terminal frames remains a fundamental yet unresolved challenge.Existing methods typically rely on dense keyframe inputs or complex prior structures,making it difficult to balance motion quality and plausibility under conditions such as sparse constraints,long-term dependencies,and diverse motion styles.To address this,we propose a motion generation framework based on a frequency-domain diffusion model,which aims to better model complex motion distributions and enhance generation stability under sparse conditions.Our method maps motion sequences to the frequency domain via the Discrete Cosine Transform(DCT),enabling more effective modeling of low-frequency motion structures while suppressing high-frequency noise.A denoising network based on self-attention is introduced to capture long-range temporal dependencies and improve global structural awareness.Additionally,a multi-objective loss function is employed to jointly optimize motion smoothness,pose diversity,and anatomical consistency,enhancing the realism and physical plausibility of the generated sequences.Comparative experiments on the Human3.6M and LaFAN1 datasets demonstrate that our method outperforms state-of-the-art approaches across multiple performance metrics,showing stronger capabilities in generating intermediate motion frames.This research offers a new perspective and methodology for human motion generation and holds promise for applications in character animation,game development,and virtual interaction.展开更多
Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of kn...Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of knowledge about the underlying modes of action and optimal treatment modalities,a thorough translational investigation of noninvasive brain stimulation in preclinical animal models is urgently needed.Thus,we reviewed the current literature on the mechanistic underpinnings of noninvasive brain stimulation in models of central nervous system impairment,with a particular emphasis on traumatic brain injury and stroke.Due to the lack of translational models in most noninvasive brain stimulation techniques proposed,we found this review to the most relevant techniques used in humans,i.e.,transcranial magnetic stimulation and transcranial direct current stimulation.We searched the literature in Pub Med,encompassing the MEDLINE and PMC databases,for studies published between January 1,2020 and September 30,2024.Thirty-five studies were eligible.Transcranial magnetic stimulation and transcranial direct current stimulation demonstrated distinct strengths in augmenting rehabilitation post-stroke and traumatic brain injury,with emerging mechanistic evidence.Overall,we identified neuronal,inflammatory,microvascular,and apoptotic pathways highlighted in the literature.This review also highlights a lack of translational surrogate parameters to bridge the gap between preclinical findings and their clinical translation.展开更多
Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in ...Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.展开更多
The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cereb...The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.展开更多
In order to obtain an accurate tide description in the China Seas, the 2-dimensional nonlinear numerical Princeton Ocean Model （POM） is employed to incorporate in situ tidal measurements both from tide gauges and TO...In order to obtain an accurate tide description in the China Seas, the 2-dimensional nonlinear numerical Princeton Ocean Model （POM） is employed to incorporate in situ tidal measurements both from tide gauges and TOPEX/POSEIDON （T/P） derived datasets by means of the variational adjoint approach in such a way that unknown internal model parameters, bottom topography, friction coefficients and open boundary conditions, for example, are adjusted during the process. The numerical model is used as a forward model. After the along-track T/P data are processed, two classical methods, i.e. harmonic and response analysis, are implemented to estimate the tide from such datasets with a domain covering the model area extending from 0° to 41°N in latitude and from 99°E to 142°E in longitude. And the results of these two methods are compared and interpreted. The numerical simulation is performed for 16 major constituents. In the data assimilation experiments, three types of unknown parameters （water depth, bottom friction and tidal open boundary conditions in the model equations） are chosen as control variables. Among the various types of data assimilation experiments, the calibration of water depth brings the most promising results. By comparing the results with selected tide gauge data, the average absolute errors are decreased from 7.9 cm to 6.8 cm for amplitude and from 13.0° to 9.0° for phase with respect to the semidiurnal tide M2 constituent, which is the largest tidal constituent in the model area. After the data assimilation experiment is performed, the comparison between model results and tide gauge observation for water levels shows that the RMS errors decrease by 9 cm for a total of 14 stations, mostly selected along the coast of China's Mainland, when a one-month period is considered, and the correlation coefficients improve for most tidal stations among these stations.展开更多
Melt ponds significantly affect Arctic sea ice thermodynamic processes.The melt pond parameterization scheme in the Los Alamos sea ice model(CICE6.0) can predict the volume,area fraction(the ratio between melt pond ar...Melt ponds significantly affect Arctic sea ice thermodynamic processes.The melt pond parameterization scheme in the Los Alamos sea ice model(CICE6.0) can predict the volume,area fraction(the ratio between melt pond area to sea ice area in a model grid),and depth of melt ponds.However,this scheme has some uncertain parameters that affect melt pond simulations.These parameters could be determined through a conventional parameter estimation method,which requires a large number of sensitivity simulations.The adjoint model can calculate the parameter sensitivity efficiently.In the present research,an adjoint model was developed for the CESM(Community Earth System Model) melt pond scheme.A melt pond parameter estimation algorithm was then developed based on the CICE6.0 sea ice model,melt pond adjoint model,and L-BFGS(Limited-memory Broyden-Fletcher-Goldfard-Shanno) minimization algorithm.The parameter estimation algorithm was verified under idealized conditions.By using MODIS(Moderate Resolution Imaging Spectroradiometer)melt pond fraction observation as a constraint and the developed parameter estimation algorithm,the melt pond aspect ratio parameter in CESM scheme,which is defined as the ratio between pond depth and pond area fraction,was estimated every eight days during summertime for two different regions in the Arctic.One region was covered by multi-year ice(MYI) and the other by first-year ice(FYI).The estimated parameter was then used in simulations and the results show that:(1) the estimated parameter varies over time and is quite different for MYI and FYI;(2) the estimated parameter improved the simulation of the melt pond fraction.展开更多
Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary ...Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary condition resulting from an adjoint model on a limited-area is no longer an issue, and yet preserve its well-poseness and optimal character in the boundary setting. The ill-poseness of over-specified spatial boundary condition is in a sense, inevitable from an adjoint model since data assimilation processes have to adapt prescribed observations that used to be over-specified at the spatial boundaries of the modeling domain. In the view of pragmatic implement, the theoretical framework of our proposed condition for spatial boundaries indeed can be reduced to the hybrid formulation of nudging filter, radiation condition taking account of ambient forcing, together with Dirichlet kind of compatible boundary condition to the observations prescribed in data assimilation procedure. All of these treatments, no doubt, are very familiar to mesoscale modelers. Key words Variational data assimilation - Adjoint model - Over-specified partial boundary condition This research work is sponsored by the National Key Programme for Developing Basic Sciences (G1998040907), the Project of Natural Science Foundation of Jiangsu Province (BK99020), the President Foundation of Nanjing University (985) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.展开更多
In the first paper in this series, a variational data assimilation of ideal tropical cyclone （TC） tracks was performed for the statistical-dynamical prediction model SD-90 by the adjoint method, and a prediction of ...In the first paper in this series, a variational data assimilation of ideal tropical cyclone （TC） tracks was performed for the statistical-dynamical prediction model SD-90 by the adjoint method, and a prediction of TC tracks was made with good accuracy for tracks containing no sharp turns. In the present paper, the cases of real TC tracks are studied. Due to the complexity of TC motion, attention is paid to the diagnostic research of TC motion. First, five TC tracks are studied. Using the data of each entire TC track, by the adjoint method, five TC tracks are fitted well, and the forces acting on the TCs are retrieved. For a given TC, the distribution of the resultant of the retrieved force and Coriolis force well matches the corresponding TC track, i.e., when a TC turns, the resultant of the retrieved force and Coriolis force acts as a centripetal force, which means that the TC indeed moves like a particle; in particular, for TC 9911, the clockwise looping motion is also fitted well. And the distribution of the resultant appears to be periodic in some cases. Then, the present method is carried out for a portion of the track data for TC 9804, which indicates that when the amount of data for a TC track is sufficient, the algorithm is stable. And finally, the same algorithm is implemented for TCs with a double-eyewall structure, namely Bilis （2000） and Winnie （1997）, and the results prove the applicability of the algorithm to TCs with complicated mesoscale structures if the TC track data are obtained every three hours.展开更多
This paper aims at a review of the work carried out to date on the adjoint assimilation of data in marine ecosys-tem models since 1995. The structure and feature of the adjoint assimilation in marine ecosystem models ...This paper aims at a review of the work carried out to date on the adjoint assimilation of data in marine ecosys-tem models since 1995. The structure and feature of the adjoint assimilation in marine ecosystem models are also introduced. To illustrate the application of the adjoint technique and its merits, a 4-variable ecosystem model coupled with a 3-D physical model is established for the Bohai Sea and the Yellow Sea. The chlorophyll concentration data derived from the SeaWiFS o-cean colour data are assimilated in the model with the technique. Some results are briefly presented.展开更多
This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate th...This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response considered in this work is a reaction-rate detector response, which provides the average interactions of particles with the respective detector or, alternatively, the time-average of the concentration of a mixture of substances in a medium. The definition of this model response includes both uncertain boundary points of the benchmark, thereby providing both direct and indirect contributions to the response sensitivities stemming from the boundaries. The exact expressions for the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the boundary and model parameters obtained in this work can serve as stringent benchmarks for inter-comparing the performances of all (deterministic and statistical) sensitivity analysis methods.展开更多
This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or tr...This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response is the value of the model’s state function (particle concentration or particle flux) at a point in phase-space, which would simulate a pointwise measurement of the respective state function. This paradigm model admits exact closed-form expressions for all of the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the model’s uncertain parameters and domain boundaries. These closed-form expressions can be used to verify the numerical results of production and/or commercial software, e.g., particle transport codes. Furthermore, this paradigm model comprises many uncertain parameters which have relative sensitivities of identical magnitudes. Therefore, this paradigm model could serve as a stringent benchmark for inter-comparing the performances of all deterministic and statistical sensitivity analysis methods, including the 2<sup>nd</sup>-CASAM.展开更多
Based on the simulation of a marine ecosystem dynamical model in the Bohai Sea, the Yellow Sea and the East China Sea, chlorophyll data are assimilated to study the spatially varying control parameters （CPs） by usin...Based on the simulation of a marine ecosystem dynamical model in the Bohai Sea, the Yellow Sea and the East China Sea, chlorophyll data are assimilated to study the spatially varying control parameters （CPs） by using the adjoint method. In this study, the CPs at some grid points are selected as the independent CPs, while the CPs at other grid points can be obtained through linear interpolation with the independent CPs. The independent CPs are uniformly selected from each 30′ × 30′area, and we confirm that the optimal influence radius is 1.2° by a twin experiment. In the following experiments, when only the maximum growth rate of phytoplankton （Vm） is estimated by two given types of spatially varying CPs, the mean relative errors of Vm are 1.22% and 0.94% while the decrease rates of the mean error of chlorophyll in the surface are 94.6% and 95.8%, respectively. When the other four CPs are estimated respectively, the results are also satisfactory, which indicates that the adjoint method has a strong ability of optimizing the prescribed CP with spatial variations. However, when all these five most important CPs are estimated simultaneously, the collocation of the changing trend of each parameter influences the estimation results remarkably. Only when the collocation of the changing trend of each parameter is consistent with the ecological mechanisms which influence the growth of the phytoplankton in marine ecosystem, could the five most important CPs be estimated more accurately.展开更多
基金supported by the National Key Research and Development Program of China(No.2022YFC3701205)the National Natural Science Foundation of China(No.41975173)the Science and Technology Development Fund of the Chinese Academy of Meteorological Sciences(No.2021KJ011)。
文摘In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation analysis on two typical co-pollution events in Beijing,occurring from July 22 to July 28,2019,and from April 25 to May 2,2020.These events were categorized into pre-trough southerly airflow type(Type 1)and post-trough northwest flow type(Type 2).Subsequently,sensitivity analyses using the GRAPES-CUACE adjoint model were performed to quantify the contributions of precursor emissions from Beijing and surrounding areas to PM_(2.5)and O_(3) concentrations in Beijing for two types of co-pollution.The results indicated that the spatiotemporal distribution of sensitive source region varied among different circulation types.Primary PM_(2.5)(PPM_(2.5))emissions from Hebei contributed the most to the 24-hour average PM_(2.5)(24-h PM_(2.5))peak concentration(41.6%-45.4%),followed by Beijing emissions(31%-35.7%).The maximum daily 8-hour average ozone peak concentration was primarily influenced by the emissions from Hebei and Beijing,with contribution ratios respectively of 32.8%-44.8% and 29%-42.1%.Additionally,NO_(x)emissions were the main contributors in Type 1,while both NO_(x)and VOCs emissions contributed similarly in Type 2.The iterative emission reduction experiments for two types of co-pollution indicated that Type 1 required emission reductions in NO_(x)(52.4%-71.8%)and VOCs(14.1%-33.8%)only.In contrast,Type 2 required combined emission reductions in NO_(x)(37.0%-65.1%),VOCs(30.7%-56.2%),and PPM_(2.5)(31%-46.9%).This study provided a reference for controlling co-pollution events and improving air quality in Beijing.
基金the World Climate Research Programme(WCRP),Climate Variability and Predictability(CLIVAR),and Global Energy and Water Exchanges(GEWEX)for facilitating the coordination of African monsoon researchsupport from the Center for Earth System Modeling,Analysis,and Data at the Pennsylvania State Universitythe support of the Office of Science of the U.S.Department of Energy Biological and Environmental Research as part of the Regional&Global Model Analysis(RGMA)program area。
文摘In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain.
文摘Climate model prediction has been improved by enhancing model resolution as well as the implementation of sophisticated physical parameterization and refinement of data assimilation systems[section 6.1 in Wang et al.(2025)].In relation to seasonal forecasting and climate projection in the East Asian summer monsoon season,proper simulation of the seasonal migration of rain bands by models is a challenging and limiting factor[section 7.1 in Wang et al.(2025)].
文摘Customer churn is the rate at which customers discontinue doing business with a company over a given time period.It is an essential measure for businesses to monitor high churn rates,as they often indicate underlying issues with services,products,or customer experience,resulting in considerable income loss.Prediction of customer churn is a crucial task aimed at retaining customers and maintaining revenue growth.Traditional machine learning(ML)models often struggle to capture complex temporal dependencies in client behavior data.To address this,an optimized deep learning(DL)approach using a Regularized Bidirectional Long Short-Term Memory(RBiLSTM)model is proposed to mitigate overfitting and improve generalization error.The model integrates dropout,L2-regularization,and early stopping to enhance predictive accuracy while preventing over-reliance on specific patterns.Moreover,this study investigates the effect of optimization techniques on boosting the training efficiency of the developed model.Experimental results on a recent public customer churn dataset demonstrate that the trained model outperforms the traditional ML models and some other DL models,such as Long Short-Term Memory(LSTM)and Deep Neural Network(DNN),in churn prediction performance and stability.The proposed approach achieves 96.1%accuracy,compared with LSTM and DNN,which attain 94.5%and 94.1%accuracy,respectively.These results confirm that the proposed approach can be used as a valuable tool for businesses to identify at-risk consumers proactively and implement targeted retention strategies.
基金funded by the Office of the Vice-President for Research and Development of Cebu Technological University.
文摘This study demonstrates a novel integration of large language models,machine learning,and multicriteria decision-making to investigate self-moderation in small online communities,a topic under-explored compared to user behavior and platform-driven moderation on social media.The proposed methodological framework(1)utilizes large language models for social media post analysis and categorization,(2)employs k-means clustering for content characterization,and(3)incorporates the TODIM(Tomada de Decisão Interativa Multicritério)method to determine moderation strategies based on expert judgments.In general,the fully integrated framework leverages the strengths of these intelligent systems in a more systematic evaluation of large-scale decision problems.When applied in social media moderation,this approach promotes nuanced and context-sensitive self-moderation by taking into account factors such as cultural background and geographic location.The application of this framework is demonstrated within Facebook groups.Eight distinct content clusters encompassing safety,harassment,diversity,and misinformation are identified.Analysis revealed a preference for content removal across all clusters,suggesting a cautious approach towards potentially harmful content.However,the framework also highlights the use of other moderation actions,like account suspension,depending on the content category.These findings contribute to the growing body of research on self-moderation and offer valuable insights for creating safer and more inclusive online spaces within smaller communities.
基金supported by the Science and Technology Research Project of Henan Province(242102241055)the Industry-University-Research Collaborative Innovation Base on Automobile Lightweight of“Science and Technology Innovation in Central Plains”(2024KCZY315)the Opening Fund of State Key Laboratory of Structural Analysis,Optimization and CAE Software for Industrial Equipment(GZ2024A03-ZZU).
文摘The moving morphable component(MMC)topology optimization method,as a typical explicit topology optimization method,has been widely concerned.In the MMC topology optimization framework,the surrogate material model is mainly used for finite element analysis at present,and the effectiveness of the surrogate material model has been fully confirmed.However,there are some accuracy problems when dealing with boundary elements using the surrogate material model,which will affect the topology optimization results.In this study,a boundary element reconstruction(BER)model is proposed based on the surrogate material model under the MMC topology optimization framework to improve the accuracy of topology optimization.The proposed BER model can reconstruct the boundary elements by refining the local meshes and obtaining new nodes in boundary elements.Then the density of boundary elements is recalculated using the new node information,which is more accurate than the original model.Based on the new density of boundary elements,the material properties and volume information of the boundary elements are updated.Compared with other finite element analysis methods,the BER model is simple and feasible and can improve computational accuracy.Finally,the effectiveness and superiority of the proposed method are verified by comparing it with the optimization results of the original surrogate material model through several numerical examples.
基金supported by the confidential research grant No.a8317。
文摘To address the issues of frequent identity switches(IDs)and degraded identification accuracy in multi object tracking(MOT)under complex occlusion scenarios,this study proposes an occlusion-robust tracking framework based on face-pedestrian joint feature modeling.By constructing a joint tracking model centered on“intra-class independent tracking+cross-category dynamic binding”,designing a multi-modal matching metric with spatio-temporal and appearance constraints,and innovatively introducing a cross-category feature mutual verification mechanism and a dual matching strategy,this work effectively resolves performance degradation in traditional single-category tracking methods caused by short-term occlusion,cross-camera tracking,and crowded environments.Experiments on the Chokepoint_Face_Pedestrian_Track test set demonstrate that in complex scenes,the proposed method improves Face-Pedestrian Matching F1 area under the curve(F1 AUC)by approximately 4 to 43 percentage points compared to several traditional methods.The joint tracking model achieves overall performance metrics of IDF1:85.1825%and MOTA:86.5956%,representing improvements of 0.91 and 0.06 percentage points,respectively,over the baseline model.Ablation studies confirm the effectiveness of key modules such as the Intersection over Area(IoA)/Intersection over Union(IoU)joint metric and dynamic threshold adjustment,validating the significant role of the cross-category identity matching mechanism in enhancing tracking stability.Our_model shows a 16.7%frame per second(FPS)drop vs.fairness of detection and re-identification in multiple object tracking(FairMOT),with its cross-category binding module adding aboute 10%overhead,yet maintains near-real-time performance for essential face-pedestrian tracking at small resolutions.
基金supported by the National Natural Science Foundation of China(Grant No.72161034).
文摘Human motion modeling is a core technology in computer animation,game development,and humancomputer interaction.In particular,generating natural and coherent in-between motion using only the initial and terminal frames remains a fundamental yet unresolved challenge.Existing methods typically rely on dense keyframe inputs or complex prior structures,making it difficult to balance motion quality and plausibility under conditions such as sparse constraints,long-term dependencies,and diverse motion styles.To address this,we propose a motion generation framework based on a frequency-domain diffusion model,which aims to better model complex motion distributions and enhance generation stability under sparse conditions.Our method maps motion sequences to the frequency domain via the Discrete Cosine Transform(DCT),enabling more effective modeling of low-frequency motion structures while suppressing high-frequency noise.A denoising network based on self-attention is introduced to capture long-range temporal dependencies and improve global structural awareness.Additionally,a multi-objective loss function is employed to jointly optimize motion smoothness,pose diversity,and anatomical consistency,enhancing the realism and physical plausibility of the generated sequences.Comparative experiments on the Human3.6M and LaFAN1 datasets demonstrate that our method outperforms state-of-the-art approaches across multiple performance metrics,showing stronger capabilities in generating intermediate motion frames.This research offers a new perspective and methodology for human motion generation and holds promise for applications in character animation,game development,and virtual interaction.
基金funded by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation):project ID 431549029-SFB 1451the Marga-und-Walter-Boll-Stiftung(#210-10-15)(to MAR)a stipend from the'Gerok Program'(Faculty of Medicine,University of Cologne,Germany)。
文摘Noninvasive brain stimulation techniques offer promising therapeutic and regenerative prospects in neurological diseases by modulating brain activity and improving cognitive and motor functions.Given the paucity of knowledge about the underlying modes of action and optimal treatment modalities,a thorough translational investigation of noninvasive brain stimulation in preclinical animal models is urgently needed.Thus,we reviewed the current literature on the mechanistic underpinnings of noninvasive brain stimulation in models of central nervous system impairment,with a particular emphasis on traumatic brain injury and stroke.Due to the lack of translational models in most noninvasive brain stimulation techniques proposed,we found this review to the most relevant techniques used in humans,i.e.,transcranial magnetic stimulation and transcranial direct current stimulation.We searched the literature in Pub Med,encompassing the MEDLINE and PMC databases,for studies published between January 1,2020 and September 30,2024.Thirty-five studies were eligible.Transcranial magnetic stimulation and transcranial direct current stimulation demonstrated distinct strengths in augmenting rehabilitation post-stroke and traumatic brain injury,with emerging mechanistic evidence.Overall,we identified neuronal,inflammatory,microvascular,and apoptotic pathways highlighted in the literature.This review also highlights a lack of translational surrogate parameters to bridge the gap between preclinical findings and their clinical translation.
文摘Myasthenia gravis is a chronic autoimmune disorder that affects the neuromuscular junction leading to fluctuating skeletal muscle fatigability. The majority of myasthenia gravis patients have detectable antibodies in their serum, targeting acetylcholine receptor, muscle-specific kinase, or related proteins. Current treatment for myasthenia gravis involves symptomatic therapy, immunosuppressive drugs such as corticosteroids, azathioprine, and mycophenolate mofetil, and thymectomy, which is primarily indicated in patients with thymoma or thymic hyperplasia. However, this condition continues to pose significant challenges including an unpredictable and variable disease progression, differing response to individual therapies, and substantial longterm side effects associated with standard treatments(including an increased risk of infections, osteoporosis, and diabetes), underscoring the necessity for a more personalized approach to treatment. Furthermore, about fifteen percent of patients, called “refractory myasthenia gravis patients”, do not respond adequately to standard therapies. In this context, the introduction of molecular therapies has marked a significant advance in myasthenia gravis management. Advances in understanding myasthenia gravis pathogenesis, especially the role of pathogenic antibodies, have driven the development of these biological drugs, which offer more selective, rapid, and safer alternatives to traditional immunosuppressants. This review aims to provide a comprehensive overview of emerging therapeutic strategies targeting specific immune pathways in myasthenia gravis, with a particular focus on preclinical evidence, therapeutic rationale, and clinical translation of B-cell depletion therapies, neonatal Fc receptor inhibitors, and complement inhibitors.
基金supported by the Grant PID2021-126715OB-IOO financed by MCIN/AEI/10.13039/501100011033 and"ERDFA way of making Europe"by the Grant PI22CⅢ/00055 funded by Instituto de Salud CarlosⅢ(ISCⅢ)+6 种基金the UFIECPY 398/19(PEJ2018-004965) grant to RGS funded by AEI(Spain)the UFIECPY-396/19(PEJ2018-004961)grant financed by MCIN (Spain)FI23CⅢ/00003 grant funded by ISCⅢ-PFIS Spain) to PMMthe UFIECPY 328/22 (PEJ-2021-TL/BMD-21001) grant to LM financed by CAM (Spain)the grant by CAPES (Coordination for the Improvement of Higher Education Personnel)through the PDSE program (Programa de Doutorado Sanduiche no Exterior)to VSCG financed by MEC (Brazil)
文摘The brain is the most complex human organ,and commonly used models,such as two-dimensional-cell cultures and animal brains,often lack the sophistication needed to accurately use in research.In this context,human cerebral organoids have emerged as valuable tools offering a more complex,versatile,and human-relevant system than traditional animal models,which are often unable to replicate the intricate architecture and functionality of the human brain.Since human cerebral organoids are a state-of-the-art model for the study of neurodevelopment and different pathologies affecting the brain,this field is currently under constant development,and work in this area is abundant.In this review,we give a complete overview of human cerebral organoids technology,starting from the different types of protocols that exist to generate different human cerebral organoids.We continue with the use of brain organoids for the study of brain pathologies,highlighting neurodevelopmental,psychiatric,neurodegenerative,brain tumor,and infectious diseases.Because of the potential value of human cerebral organoids,we describe their use in transplantation,drug screening,and toxicology assays.We also discuss the technologies available to study cell diversity and physiological characteristics of organoids.Finally,we summarize the limitations that currently exist in the field,such as the development of vasculature and microglia,and highlight some of the novel approaches being pursued through bioengineering.
文摘In order to obtain an accurate tide description in the China Seas, the 2-dimensional nonlinear numerical Princeton Ocean Model （POM） is employed to incorporate in situ tidal measurements both from tide gauges and TOPEX/POSEIDON （T/P） derived datasets by means of the variational adjoint approach in such a way that unknown internal model parameters, bottom topography, friction coefficients and open boundary conditions, for example, are adjusted during the process. The numerical model is used as a forward model. After the along-track T/P data are processed, two classical methods, i.e. harmonic and response analysis, are implemented to estimate the tide from such datasets with a domain covering the model area extending from 0° to 41°N in latitude and from 99°E to 142°E in longitude. And the results of these two methods are compared and interpreted. The numerical simulation is performed for 16 major constituents. In the data assimilation experiments, three types of unknown parameters （water depth, bottom friction and tidal open boundary conditions in the model equations） are chosen as control variables. Among the various types of data assimilation experiments, the calibration of water depth brings the most promising results. By comparing the results with selected tide gauge data, the average absolute errors are decreased from 7.9 cm to 6.8 cm for amplitude and from 13.0° to 9.0° for phase with respect to the semidiurnal tide M2 constituent, which is the largest tidal constituent in the model area. After the data assimilation experiment is performed, the comparison between model results and tide gauge observation for water levels shows that the RMS errors decrease by 9 cm for a total of 14 stations, mostly selected along the coast of China's Mainland, when a one-month period is considered, and the correlation coefficients improve for most tidal stations among these stations.
基金funded by the National Key R&D Program of China (Grant No.2018YFA0605904)。
文摘Melt ponds significantly affect Arctic sea ice thermodynamic processes.The melt pond parameterization scheme in the Los Alamos sea ice model(CICE6.0) can predict the volume,area fraction(the ratio between melt pond area to sea ice area in a model grid),and depth of melt ponds.However,this scheme has some uncertain parameters that affect melt pond simulations.These parameters could be determined through a conventional parameter estimation method,which requires a large number of sensitivity simulations.The adjoint model can calculate the parameter sensitivity efficiently.In the present research,an adjoint model was developed for the CESM(Community Earth System Model) melt pond scheme.A melt pond parameter estimation algorithm was then developed based on the CICE6.0 sea ice model,melt pond adjoint model,and L-BFGS(Limited-memory Broyden-Fletcher-Goldfard-Shanno) minimization algorithm.The parameter estimation algorithm was verified under idealized conditions.By using MODIS(Moderate Resolution Imaging Spectroradiometer)melt pond fraction observation as a constraint and the developed parameter estimation algorithm,the melt pond aspect ratio parameter in CESM scheme,which is defined as the ratio between pond depth and pond area fraction,was estimated every eight days during summertime for two different regions in the Arctic.One region was covered by multi-year ice(MYI) and the other by first-year ice(FYI).The estimated parameter was then used in simulations and the results show that:(1) the estimated parameter varies over time and is quite different for MYI and FYI;(2) the estimated parameter improved the simulation of the melt pond fraction.
基金the National Key Programme for Developing Basic Sciences(G1998040907)the Project of Natural Science Foundation of Jiangsu Pr
文摘Theoretical argumentation for so-called suitable spatial condition is conducted by the aid of homotopy framework to demonstrate that the proposed boundary condition does guarantee that the over-specification boundary condition resulting from an adjoint model on a limited-area is no longer an issue, and yet preserve its well-poseness and optimal character in the boundary setting. The ill-poseness of over-specified spatial boundary condition is in a sense, inevitable from an adjoint model since data assimilation processes have to adapt prescribed observations that used to be over-specified at the spatial boundaries of the modeling domain. In the view of pragmatic implement, the theoretical framework of our proposed condition for spatial boundaries indeed can be reduced to the hybrid formulation of nudging filter, radiation condition taking account of ambient forcing, together with Dirichlet kind of compatible boundary condition to the observations prescribed in data assimilation procedure. All of these treatments, no doubt, are very familiar to mesoscale modelers. Key words Variational data assimilation - Adjoint model - Over-specified partial boundary condition This research work is sponsored by the National Key Programme for Developing Basic Sciences (G1998040907), the Project of Natural Science Foundation of Jiangsu Province (BK99020), the President Foundation of Nanjing University (985) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.
基金This work was supported jointly by the Typhoon Foundation of Shanghaiby LASC of the Institute of Atmospheric Physics of the Chinese Academy of Sciencesby the National Natural Science Foundation of China under Grant No. 40633030.
文摘In the first paper in this series, a variational data assimilation of ideal tropical cyclone （TC） tracks was performed for the statistical-dynamical prediction model SD-90 by the adjoint method, and a prediction of TC tracks was made with good accuracy for tracks containing no sharp turns. In the present paper, the cases of real TC tracks are studied. Due to the complexity of TC motion, attention is paid to the diagnostic research of TC motion. First, five TC tracks are studied. Using the data of each entire TC track, by the adjoint method, five TC tracks are fitted well, and the forces acting on the TCs are retrieved. For a given TC, the distribution of the resultant of the retrieved force and Coriolis force well matches the corresponding TC track, i.e., when a TC turns, the resultant of the retrieved force and Coriolis force acts as a centripetal force, which means that the TC indeed moves like a particle; in particular, for TC 9911, the clockwise looping motion is also fitted well. And the distribution of the resultant appears to be periodic in some cases. Then, the present method is carried out for a portion of the track data for TC 9804, which indicates that when the amount of data for a TC track is sufficient, the algorithm is stable. And finally, the same algorithm is implemented for TCs with a double-eyewall structure, namely Bilis （2000） and Winnie （1997）, and the results prove the applicability of the algorithm to TCs with complicated mesoscale structures if the TC track data are obtained every three hours.
文摘This paper aims at a review of the work carried out to date on the adjoint assimilation of data in marine ecosys-tem models since 1995. The structure and feature of the adjoint assimilation in marine ecosystem models are also introduced. To illustrate the application of the adjoint technique and its merits, a 4-variable ecosystem model coupled with a 3-D physical model is established for the Bohai Sea and the Yellow Sea. The chlorophyll concentration data derived from the SeaWiFS o-cean colour data are assimilated in the model with the technique. Some results are briefly presented.
文摘This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response considered in this work is a reaction-rate detector response, which provides the average interactions of particles with the respective detector or, alternatively, the time-average of the concentration of a mixture of substances in a medium. The definition of this model response includes both uncertain boundary points of the benchmark, thereby providing both direct and indirect contributions to the response sensitivities stemming from the boundaries. The exact expressions for the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the boundary and model parameters obtained in this work can serve as stringent benchmarks for inter-comparing the performances of all (deterministic and statistical) sensitivity analysis methods.
文摘This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response is the value of the model’s state function (particle concentration or particle flux) at a point in phase-space, which would simulate a pointwise measurement of the respective state function. This paradigm model admits exact closed-form expressions for all of the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the model’s uncertain parameters and domain boundaries. These closed-form expressions can be used to verify the numerical results of production and/or commercial software, e.g., particle transport codes. Furthermore, this paradigm model comprises many uncertain parameters which have relative sensitivities of identical magnitudes. Therefore, this paradigm model could serve as a stringent benchmark for inter-comparing the performances of all deterministic and statistical sensitivity analysis methods, including the 2<sup>nd</sup>-CASAM.
基金The State Ministry of Science and Technology of China under contract No. 2007AA09Z118the National Natural Science Foundation of China under contract No. 41076006the Ministry of Education’s 111 Project under contract No. B07036
文摘Based on the simulation of a marine ecosystem dynamical model in the Bohai Sea, the Yellow Sea and the East China Sea, chlorophyll data are assimilated to study the spatially varying control parameters （CPs） by using the adjoint method. In this study, the CPs at some grid points are selected as the independent CPs, while the CPs at other grid points can be obtained through linear interpolation with the independent CPs. The independent CPs are uniformly selected from each 30′ × 30′area, and we confirm that the optimal influence radius is 1.2° by a twin experiment. In the following experiments, when only the maximum growth rate of phytoplankton （Vm） is estimated by two given types of spatially varying CPs, the mean relative errors of Vm are 1.22% and 0.94% while the decrease rates of the mean error of chlorophyll in the surface are 94.6% and 95.8%, respectively. When the other four CPs are estimated respectively, the results are also satisfactory, which indicates that the adjoint method has a strong ability of optimizing the prescribed CP with spatial variations. However, when all these five most important CPs are estimated simultaneously, the collocation of the changing trend of each parameter influences the estimation results remarkably. Only when the collocation of the changing trend of each parameter is consistent with the ecological mechanisms which influence the growth of the phytoplankton in marine ecosystem, could the five most important CPs be estimated more accurately.
