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Numerical Simulation of Azimuthal Uniformity of Injection Currents in Single-Point-Feed Induction Voltage Adders 被引量:1
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作者 魏浩 孙凤举 +4 位作者 尹佳辉 呼义翔 梁天学 丛培天 邱爱慈 《Plasma Science and Technology》 SCIE EI CAS CSCD 2015年第3期235-240,共6页
In order to investigate the injection current uniformity around the induction cell bores, two fully electromagnetic (EM) models are respectively established for a single-stage induction cell and an induction voltage... In order to investigate the injection current uniformity around the induction cell bores, two fully electromagnetic (EM) models are respectively established for a single-stage induction cell and an induction voltage adder (IVA) with three cells stacked in series, without considering electron emission. By means of these two models, some factors affecting the injection current uni- formity are simulated and analyzed, such as the impedances of adders and loads, cell locations, and feed timing of parallel driving pulses. Simulation results indicate that higher impedances of adder and loads are slightly beneficial to improve injection current uniformity. As the impedances of adder and loads increase from 5 Ω to 30Ω, the asymmetric coefficient of feed currents decreases from 10.3% to 6.6%. The current non-uniformity within the first cell is a little worse than that in other downstream cells. Simulation results also show that the feed timing would greatly affect current waveforms, and consequently cause some distortion in pulse fronts of cell output voltages. For a given driving pulse with duration time of 70-80 ns, the feed timing with a time deviation of less than 20 ns is acceptable for the three-cell IVAs, just causing the rise time of output voltages to increase about 5 ns at most and making the peak voltage decrease by 3.5%. 展开更多
关键词 induction voltage adders (IVA) induction cell single-point feed current uni- formity electromagnetic model
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Study and Evaluation in CMOS Full Adders
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作者 陈国章 陈昊 何丕廉 《Transactions of Tianjin University》 EI CAS 2003年第1期54-57,共4页
Low power adder circuits, SERF, 10T Ⅰ,10T Ⅱ,10T Ⅲ and a complementary adder (28T) at physical layout level are evaluated. Simulations based on the extracted adder circuit layouts are run to assess how various circu... Low power adder circuits, SERF, 10T Ⅰ,10T Ⅱ,10T Ⅲ and a complementary adder (28T) at physical layout level are evaluated. Simulations based on the extracted adder circuit layouts are run to assess how various circuit setups can impact the speed and power consumption. In addition, impacts of output inverters on the circuit performance of modified SERF and 10T adders due to threshold loss problem are also examined. Differences among these adders are addressed and applications of these adders are suggested. 展开更多
关键词 CMOS full adder 28T adder
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Fast Signed-Digit Multi-operand Decimal Adders
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作者 Jeff Rebacz Erdal Oruklu Jafar Saniie 《Circuits and Systems》 2011年第3期225-236,共12页
Decimal arithmetic is desirable for high precision requirements of many financial, industrial and scientific applications. Furthermore, hardware support for decimal arithmetic has gained momentum with IEEE 754-2008, w... Decimal arithmetic is desirable for high precision requirements of many financial, industrial and scientific applications. Furthermore, hardware support for decimal arithmetic has gained momentum with IEEE 754-2008, which standardized decimal floating-point. This paper presents a new architecture for two operand and multi-operand signed-digit decimal addition. Signed-digit architectures are advantageous because there are no carry-propagate chains. The proposed signed-digit adder reduces the critical path delay by parallelizing the correction stage inherent to decimal addition. For performance evaluation, we synthesize and compare multiple unsigned and signed-digit multi-operand decimal adder architectures on 0.18μm CMOS VLSI technology. Synthesis results for 2, 4, 8, and 16 operands with 8 decimal digits provide critical data in determining each adder's performance and scalability. 展开更多
关键词 Computer ARITHMETIC Decimal ARITHMETIC Signed-Digit Multi-operand ADDER BCD
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Quantum Circuit Implementation and Resource Evaluation of Ballet‑p/k Under Grover’s Attack
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作者 HONG Rui-Peng ZHANG Lei +3 位作者 PANG Chen-Xu LI Guo-Yuan DING Ding WANG Jian-Xin 《密码学报(中英文)》 北大核心 2025年第5期1178-1194,共17页
The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for thre... The advent of Grover’s algorithm presents a significant threat to classical block cipher security,spurring research into post-quantum secure cipher design.This study engineers quantum circuit implementations for three versions of the Ballet family block ciphers.The Ballet‑p/k includes a modular-addition operation uncommon in lightweight block ciphers.Quantum ripple-carry adder is implemented for both“32+32”and“64+64”scale to support this operation.Subsequently,qubits,quantum gates count,and quantum circuit depth of three versions of Ballet algorithm are systematically evaluated under quantum computing model,and key recovery attack circuits are constructed based on Grover’s algorithm against each version.The comprehensive analysis shows:Ballet-128/128 fails to NIST Level 1 security,while when the resource accounting is restricted to the Clifford gates and T gates set for the Ballet-128/256 and Ballet-256/256 quantum circuits,the design attains Level 3. 展开更多
关键词 Grover’s algorithm quantum circuit Ballet family block ciphers quantum ripple-carry adder
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基于自适应CSA的多操作数加法器设计
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作者 王立华 崔可欣 +1 位作者 付文杰 刘晨光 《鲁东大学学报(自然科学版)》 2025年第3期222-232,共11页
多操作数加法器是数字集成电路设计的基本算术单元之一,其逻辑优化是逻辑综合流程中至关重要的一部分。为了在逻辑综合过程中尽可能地提升多操作数加法器的性能,降低延迟,本文设计了一种基于自适应进位保留加法器(carry-save adder, CSA... 多操作数加法器是数字集成电路设计的基本算术单元之一,其逻辑优化是逻辑综合流程中至关重要的一部分。为了在逻辑综合过程中尽可能地提升多操作数加法器的性能,降低延迟,本文设计了一种基于自适应进位保留加法器(carry-save adder, CSA)的多操作数加法器架构。该架构采用Wallace树结构实现多操作数加法器的设计,降低加法操作导致的延迟,并在此基础上,通过改进Wallace树结构中的CSA压缩部分,进一步降低延迟。本文以SMIC 28nm工艺库为目标库,运用上述算法对多个多操作数相加的RTL(register-transfer level)设计执行逻辑综合,得到多操作数加法器。实验结果表明,在16~128位宽输入下,本加法器可显著优化性能,延迟时间平均降低31.2%,面积平均减少36.5%,功耗平均降低70.98%。 展开更多
关键词 多操作数加法器 carry-save adder 自适应方法 Wallace树结构 逻辑综合
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Introducing scalable 1-bit full adders for designing quantum-dot cellular automata arithmetic circuits 被引量:1
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作者 Hamideh KHAJEHNASIR-JAHROMI Pooya TORKZADEH Massoud DOUSTI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2022年第8期1264-1276,共13页
Designing logic circuits using complementary metal-oxide-semiconductor(CMOS)technology at the nano scale has been faced with various challenges recently.Undesirable leakage currents,the short-effect channel,and high e... Designing logic circuits using complementary metal-oxide-semiconductor(CMOS)technology at the nano scale has been faced with various challenges recently.Undesirable leakage currents,the short-effect channel,and high energy dissipation are some of the concerns.Quantum-dot cellular automata(QCA)represent an appropriate alternative for possible CMOS replacement in the future because it consumes an insignificant amount of energy compared to the standard CMOS.The key point of designing arithmetic circuits is based on the structure of a 1-bit full adder.A low-complexity full adder block is beneficial for developing various intricate structures.This paper represents scalable 1-bit QCA full adder structures based on cell interaction.Our proposed full adders encompass preference aspects of QCA design,such as a low number of cells used,low latency,and small area occupation.Also,the proposed structures have been expanded to larger circuits,including a 4-bit ripple carry adder(RCA),a 4-bit ripple borrow subtractor(RBS),an add/sub circuit,and a 2-bit array multiplier.All designs were simulated and verified using QCA Designer-E version 2.2.This tool can estimate the energy dissipation as well as evaluate the performance of the circuits.Simulation results showed that the proposed designs are efficient in complexity,area,latency,cost,and energy dissipation. 展开更多
关键词 Quantum-dot cellular automata(QCA) Full adder Ripple carry adder(RCA) Add/sub circuit Multiplier
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Area-Optimized BCD-4221 VSLI Adder Architecture for High-Performance Computing 被引量:1
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作者 Dharamvir Kumar Manoranjan Pradhan 《Journal of Harbin Institute of Technology(New Series)》 CAS 2024年第3期31-38,共8页
Decimal arithmetic circuits are promising to provide a solution for accurate decimal arithmetic operations which are not possible with binary arithmetic circuits.They can be used in banking,commercial and financial tr... Decimal arithmetic circuits are promising to provide a solution for accurate decimal arithmetic operations which are not possible with binary arithmetic circuits.They can be used in banking,commercial and financial transactions,scientific measurements,etc.This article presents the Very Large Scale Integration(VLSI)design of Binary Coded Decimal(BCD)-4221 area-optimized adder architecture using unconventional BCD-4221 representation.Unconventional BCD number representations such as BCD4221 also possess the additional advantage of more effectively representing the 10's complement representation which can be used to accelerate the decimal arithmetic operations.The design uses a binary Carry Lookahead Adder(CLA)along with some other logic blocks which are required to perform internal calculations with BCD-4221 numbers.The design is verified by using Xilinx Vivado 2016.1.Synthesis results have been obtained by Cadence Genus16.1 synthesis tool using 90 nm technology.The performance parameters such as area,power,delay,and area-delay Product(ADP)are compared with earlier reported circuits.Our proposed circuit shows significant area and ADP improvement over existing designs. 展开更多
关键词 VLSI design unconventional BCD representation BCD adder circuit computer arithmetic digital circuit
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高速浮点乘法器设计 被引量:7
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作者 吴金 应征 《电路与系统学报》 CSCD 北大核心 2005年第6期6-11,共6页
设计了一种符合IEEE-754标准的32bits高速CMOS浮点乘法器。该乘法器采用MBA算法和基于4:2compressor的树型结构完成CarrySave形式的部分积压缩,再由高速CarrySelect加法器求得乘积。电路设计采用了新型的高速加法运算单元。乘法器采用0... 设计了一种符合IEEE-754标准的32bits高速CMOS浮点乘法器。该乘法器采用MBA算法和基于4:2compressor的树型结构完成CarrySave形式的部分积压缩,再由高速CarrySelect加法器求得乘积。电路设计采用了新型的高速加法运算单元。乘法器采用0.35μm制程,内含19,197个晶体管。3.3V工作电压下(室温),乘法器延迟时间为3.807ns,功耗为107mW@100MHz。 展开更多
关键词 乘法器 Modified BOOTH algorithm 4:2 COMPRESSOR ROUND full ADDER
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尿纤维连接蛋白检测在膀胱癌患者中的临床应用 被引量:1
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作者 赵莹 张杰 范剑 《现代预防医学》 CAS 北大核心 2006年第10期1993-1995,共3页
目的:探讨尿纤维连接蛋白(Fibronectin,Fn)在膀胱癌患者中的临床应用价值。方法:采用ELISA检测73例膀胱癌患者(组1)、45例其他泌尿生殖系统疾病患者(组2)和50例健康人的尿Fn含量(对照组,组3),并同时测定其尿肌酐(Creatin,Cr),计算尿Fn/... 目的:探讨尿纤维连接蛋白(Fibronectin,Fn)在膀胱癌患者中的临床应用价值。方法:采用ELISA检测73例膀胱癌患者(组1)、45例其他泌尿生殖系统疾病患者(组2)和50例健康人的尿Fn含量(对照组,组3),并同时测定其尿肌酐(Creatin,Cr),计算尿Fn/尿Cr比值。比较各组人群尿Fn、尿Fn/Cr之间的差异,并分析不同肿瘤分期分级膀胱癌患者的尿Fn、尿Fn/Cr比值之间的差异。结果:膀胱癌患者组尿Fn含量(618·51±368·54)μg/L、Fn/Cr比值(166·03±298·65)mg/mol明显高于对照组的尿Fn含量(175·17±91·89)μg/L、尿Fn/Cr比值(31·37±34·04)mg/mol(P=0·0063,P=0·026)及其他泌尿生殖系统疾病患者组的尿Fn含量(214·48±142·40)μg/L、尿Fn/Cr比值(40·19±73·71)mg/mol(P=0·0089,P=0·047)。受试者工作曲线(ReceiverOperatingCharacteristicCurve,ROC曲线)显示:尿Fn诊断膀胱癌的灵敏度和特异度分别为78·1%和76·2%,尿Fn/Cr诊断膀胱癌的灵敏度和特异度为83·1%和79·2%。另外,不同肿瘤分期分级的膀胱癌患者的尿Fn含量,尿Fn/Cr比值也有明显差异。结论:尿Fn和Fn/Cr在膀胱癌患者的临床诊断方面有着重要的应用价值,是诊断膀胱癌的一种较理想的实验室指标,并可用于膀胱癌患者的预后评估。 展开更多
关键词 纤维连接蛋白(Fn) 膀胱癌(B1adder Cancer) 受试者工作曲线(ROC曲线)
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基于修正ANT逻辑高速树形32 BitCarry Lookahead加法器 被引量:1
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作者 吴艳 罗岚 《电子器件》 EI CAS 2006年第2期553-556,560,共5页
一种用修正全NMOS管逻辑(ANT)实现的树形结构高速32bitcarryLookahead加法器,使用两相时钟动态CMOS逻辑、修正不反向ANT逻辑和二进制树形结构实现。该加法器运用0.25μm工艺,文中给出了修正ANT逻辑中所有晶体管的宽长尺寸和仿真结果,最... 一种用修正全NMOS管逻辑(ANT)实现的树形结构高速32bitcarryLookahead加法器,使用两相时钟动态CMOS逻辑、修正不反向ANT逻辑和二进制树形结构实现。该加法器运用0.25μm工艺,文中给出了修正ANT逻辑中所有晶体管的宽长尺寸和仿真结果,最高工作频率为2GHz,计算结果在3.5个时钟周期后有效。 展开更多
关键词 树形 32位carry look ahead adder(CLA) 全NMOS管逻辑(ANT)
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Efficient CNTFET-based Ternary Full Adder Cells for Nanoelectronics 被引量:1
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作者 Mohammad Hossein Moaiyeri Reza Faghih Mirzaee +1 位作者 Keivan Navi Omid Hashemipour 《Nano-Micro Letters》 SCIE EI CAS 2011年第1期43-50,共8页
This paper presents two new efficient ternary Full Adder cells for nanoelectronics. These CNTFETbased ternary Full Adders are designed based on the unique characteristics of the CNTFET device, such as the capability o... This paper presents two new efficient ternary Full Adder cells for nanoelectronics. These CNTFETbased ternary Full Adders are designed based on the unique characteristics of the CNTFET device, such as the capability of setting the desired threshold voltages by adopting proper diameters for the nanotubes as well as the same carrier mobilities for the N-type and P-type devices. These characteristics of CNTFETs make them very suitable for designing high-performance multiple-Vth structures. The proposed structures reduce the number of the transistors considerably and have very high driving capability. The presented ternary Full Adders are simulated using Synopsys HSPICE with 32 nm CNTFET technology to evaluate their performance and to confirm their correct operation. 展开更多
关键词 CNTFET Multiple-Valued logic Ternary logic Ternary Full Adder Multiple-Vth design
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New Design Methodologies for High Speed Low-Voltage 1-Bit CMOS Full Adder Circuits 被引量:1
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作者 Subodh Wairya Rajendra Kumar Nagaria Sudarshan Tiwari 《Computer Technology and Application》 2011年第3期190-198,共9页
New methodologies for l-Bit XOR-XNOR full- adder circuits are proposed to improve the speed and power as these circuits are basic building blocks for ALU circuit implementation. This paper presents comparative study o... New methodologies for l-Bit XOR-XNOR full- adder circuits are proposed to improve the speed and power as these circuits are basic building blocks for ALU circuit implementation. This paper presents comparative study of high-speed, low-power and low voltage full adder circuits. Simulation results illustrate the superiority of the proposed adder circuit against the conventional complementary metal-oxide-semiconductor (CMOS), complementary pass-transistor logic (CPL), TG, and Hybrid adder circuits in terms of delay, power and power delay product (PDP). Simulation results reveal that the proposed circuit exhibits lower PDP and is more power efficient and faster when compared with the best available 1-bit full adder circuits. The design is implemented on UMC 0.18 μm process models in Cadence Virtuoso Schematic Composer at 1.8 V single ended supply voltage and simulations are carried out on Spectre S. 展开更多
关键词 Full adder circuits complementary pass-transistor logic (CPL) complementary CMOS high-speed circuits hybrid fulladder XOR-XNOR gate.
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高性能全加器电路版图优化设计研究 被引量:2
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作者 郭佳兴 王金梅 韩国英 《宁夏电力》 2023年第2期51-58,共8页
在现有全加器研究基础上,提出一种高性能全加器改进电路(improved full adder circuit,IFAC),通过改进全加器电路结构,优化电路元件工作数量,旨在提升加法器逻辑功能与运行状态。采用Candence软件搭载130 nm芯片锻造工艺,引入欧拉路径... 在现有全加器研究基础上,提出一种高性能全加器改进电路(improved full adder circuit,IFAC),通过改进全加器电路结构,优化电路元件工作数量,旨在提升加法器逻辑功能与运行状态。采用Candence软件搭载130 nm芯片锻造工艺,引入欧拉路径快速判寻法设计其电路版图,验证版图规则的合理性,并利用版图验证工具Dracula对电路进行仿真测试,结果表明本文所设计的全加器较常规全加器在处理复杂网络精确度、传输延迟时间、低功耗稳定运行及芯片面积方面有所提升。 展开更多
关键词 欧拉路径快速判寻法 全加器改进电路(improved full adder circuit IFAC) 纳米工艺 Candence 芯片面积
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Single-bit full adder and logic gate based on synthetic antiferromagnetic bilayer skyrmions
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作者 Kai Yu Mak Jing Xia +5 位作者 Xi-Chao Zhang Li Li Mouad Fattouhi Motohiko Ezawa Xiao-Xi Liu Yan Zhou 《Rare Metals》 SCIE EI CAS CSCD 2022年第7期2249-2258,共10页
Skyrmion-based devices are promising candi-dates for non-volatile memory and low-delay time com-putation.Many skyrmion-based devices execute operation by controlling skyrmion trajectory,which can be impeded by the sky... Skyrmion-based devices are promising candi-dates for non-volatile memory and low-delay time com-putation.Many skyrmion-based devices execute operation by controlling skyrmion trajectory,which can be impeded by the skyrmion Hall effect.Here,the design of skyrmion-based arithmetic devices built on synthetic antiferromag-netic(SyAF)structures is presented,where the structure can greatly suppress skyrmion Hall effect.In this study,the operations of skyrmion-based half adder,full adder,and XOR logic gate are executed by introducing geometric notches and tilted edges,which can annihilate or diverge skyrmion.Performance of these skyrmion-based devices is evaluated,where the delay time and energy-delay product of the single-bit full adder are 1.95 ns and 2.50×10^(-22)Js,which are only 12%and 79%those of the previously proposed skyrmion-based single-bit full adder.This improvement is significant in the construction of ripple-carry adder and ripple-carry adder-subtractor.Therefore,our skyrmion-based SyAF arithmetic device is a promising candidate to develop high-speed spintronic devices. 展开更多
关键词 SKYRMION Full adder Synthetic antiferromagnet Lowdelaytime electronics Micromagnets
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Design of Multi-Valued Logic Circuit Using Carbon Nano Tube Field Transistors
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作者 S.V.Ratankumar L.Koteswara Rao M.Kiran Kumar 《Computers, Materials & Continua》 SCIE EI 2022年第12期5283-5298,共16页
The design of a three-input logic circuit using carbon nanotube field effect transistors(CNTFETs)is presented.Ternary logic must be an exact replacement for dual logic since it performs straightforwardly in digital de... The design of a three-input logic circuit using carbon nanotube field effect transistors(CNTFETs)is presented.Ternary logic must be an exact replacement for dual logic since it performs straightforwardly in digital devices,which is why this design is so popular,and it also reduces chip area,both of which are examples of circuit overheads.The proposed module we have investigated is a triple-logic-based one,based on advanced technology CNTFETs and an emphasis on minimizing delay times at various values,as well as comparisons of the design working with various load capacitances.Comparing the proposed design with the existing design,the delay times was reduced from 66.32 to 16.41 ps,i.e.,a 75.26%reduction.However,the power dissipation was not optimized,and increased by 1.44%compared to the existing adder.The number of transistors was also reduced,and the product of power and delay(P∗D)achieved a value of 0.0498053 fJ.An improvement at 1 V was also achieved.A load capacitance(fF)was measured at different values,and the average delay measured for different values of capacitance had a maximum of 83.60 ps and a minimum of 22.54 ps,with a range of 61.06 ps.The power dissipations ranged from a minimum of 3.38μW to a maximum of 6.49μW.Based on these results,the use of this CNTFET half-adder design in multiple Boolean circuits will be a useful addition to circuit design. 展开更多
关键词 Carbon nanotube field effect transistor(CNTFET) multivalued logic(MVL) ternary adder Hewlett simulation program with integrated circuit emphasis(HSPICE) chirality(nm) ADDER
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Research of magnetic self-balance used in a repetitive high voltage rectangular waveform pulse adder
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作者 周乾宇 童立青 刘克富 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第1期47-53,共7页
Compared with a sinusoidal operation, pulsed operation has more homogeneity and more efficiency in dielectric barrier discharge. In this paper, an improved pulse adder is designed and assembled to create repetitive hi... Compared with a sinusoidal operation, pulsed operation has more homogeneity and more efficiency in dielectric barrier discharge. In this paper, an improved pulse adder is designed and assembled to create repetitive high voltage rectangular pulses when resistive loads or capacitive loads exist. Beyond the normal pulse adder based on solid-state switches, additional metal- oxide-semiconductor field effect transistors are used in each stage for a faster falling edge. Further, the voltage difference between stages is eliminated by balancing windings. In this paper, we represent our theoretical derivation, software simulations and hardware experiments on magnetic self-balance. The experiments show that the voltage difference between stages is eliminated by balancing windings, which matches the result of simulations with almost identical circuits and parameters. 展开更多
关键词 pulse adder fast falling edge balancing windings magnetic self-balance dielectricbarrier discharge
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Performance Measurement of Energy Efficient and Highly Scalable Hybrid Adder
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作者 B.Annapoorani P.Marikkannu 《Computer Systems Science & Engineering》 SCIE EI 2023年第6期2659-2672,共14页
The adders are the vital arithmetic operation for any arithmetic operations like multiplication,subtraction,and division.Binary number additions are performed by the digital circuit known as the adder.In VLSI(Very Lar... The adders are the vital arithmetic operation for any arithmetic operations like multiplication,subtraction,and division.Binary number additions are performed by the digital circuit known as the adder.In VLSI(Very Large Scale Integration),the full adder is a basic component as it plays a major role in designing the integrated circuits applications.To minimize the power,various adder designs are implemented and each implemented designs undergo defined drawbacks.The designed adder requires high power when the driving capability is perfect and requires low power when the delay occurred is more.To overcome such issues and to obtain better performance,a novel parallel adder is proposed.The design of adder is initiated with 1 bit and has been extended up to 32 bits so as verify its scalability.This proposed novel parallel adder is attained from the carry look-ahead adder.The merits of this suggested adder are better speed,power consumption and delay,and the capability in driving.Thus designed adders are verified for different supply,delay,power,leakage and its performance is found to be superior to competitive Manchester Carry Chain Adder(MCCA),Carry Look Ahead Adder(CLAA),Carry Select Adder(CSLA),Carry Select Adder(CSA)and other adders. 展开更多
关键词 VLSI full adder carry look ahead adder novel parallel adder
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Measurement Uncertainty and Error Analysis
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《计量学报》 CSCD 1991年第S1期98-99,共2页
12001 Transformational Logic of Numbers of PurseEquivalence and its Error. Xiao Mingyao: 1(3). 1980pp 190--197Multiplier or counter --type adder can be usually used torealize the multiplication of two multidigit figur... 12001 Transformational Logic of Numbers of PurseEquivalence and its Error. Xiao Mingyao: 1(3). 1980pp 190--197Multiplier or counter --type adder can be usually used torealize the multiplication of two multidigit figures. Thispaper Introduces a Simple method, namely. the 展开更多
关键词 FIGURES MULTIPLICATION NUMBERS COUNTER instrument ADDER FREEDOM quant ordinary grees
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Balanced biosynthesis and trigger threshold resulting in a double adder mechanism of cell size control
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作者 Leilei Li 《Communications in Theoretical Physics》 SCIE CAS CSCD 2021年第8期146-159,共14页
How cells accomplish cell size homeostasis is a fascinating topic, and several cell size regulation mechanisms were proposed: timer, sizer, and adder. Recently the adder model has received a great deal of attention. A... How cells accomplish cell size homeostasis is a fascinating topic, and several cell size regulation mechanisms were proposed: timer, sizer, and adder. Recently the adder model has received a great deal of attention. Adder property was also found in the DNA replication cycle. This paper aims to explain the adder phenomenon both in the division-centric picture and replication-centric picture at the molecular level. We established a self-replication model, and the system reached a steady state quickly based on evolution rules. We collected tens of thousands of cells in the same trajectory and calculated the Pearson correlation coefficient between biological variables to decide which regulatory mechanism was adopted by cells. Our simulation results confirmed the double-adder mechanism. Chromosome replication initiation and cell division control are independent and regulated by respective proteins.Cell size homeostasis originates from division control and has nothing to do with replication initiation control. At a slow growth rate, the deviation from adder toward sizer comes from a significant division protein degradation rate when division protein is auto-inhibited. Our results indicated the two necessary conditions in the double-adder mechanism: one is balanced biosynthesis, and the other is that there is a protein trigger threshold to inspire DNA replication initiation and cell division. Our results give insight to the regulatory mechanism of cell size and instructive to synthetic biology. 展开更多
关键词 cell size control cell size homeostasis cell cycle growth law double adder critical initiation size single cell
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A Novel Design of Octal-Valued Logic Full Adder Using Light Color State Model
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作者 Ahmed Talal Osama Abu-Elnasr Samir Elmougy 《Computers, Materials & Continua》 SCIE EI 2021年第6期3487-3503,共17页
Due to the demand of high computational speed for processing big data that requires complex data manipulations in a timely manner,the need for extending classical logic to construct new multi-valued optical models bec... Due to the demand of high computational speed for processing big data that requires complex data manipulations in a timely manner,the need for extending classical logic to construct new multi-valued optical models becomes a challenging and promising research area.This paper establishes a novel octal-valued logic design model with new optical gates construction based on the hypothesis of Light Color State Model to provide an efficient solution to the limitations of computational processing inherent in the electronics computing.We provide new mathematical definitions for both of the binary OR function and the PLUS operation in multi valued logic that is used as the basis of novel construction for the optical full adder model.Four case studies were used to assure the validity of the proposed adder.These cases proved that the proposed optical 8-valued logic models provide significantly more information to be packed within a single bit and therefore the abilities of data representation and processing is increased. 展开更多
关键词 Mathematical modeling numerical simulations optical logic optics in computing multi-valued logic full adder
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