Objective To investigate the possible mechanism by which curcumio protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with fle...Objective To investigate the possible mechanism by which curcumio protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with flee access to water. On the third day, the animals were fasted for a further 24 h with no access to water followed by surgery. Rats received different doses of curcumin （20, 40, and 80 mg/kg） or vehicle by oral gavage. Nineteen hours after ulcer induction, the rats were killed by decapitation. Stomach was opened along the greater curvature and ulcerative lesions were counted. Total juice acidity, neutrophils activity, mitochondrial activity, total antioxidants, paraoxonase （PON 1）/arylesterase and total peroxides were evaluated. DNA fragmentation （%） and pro-inflammatory cytokine IL-6 level were measured. The level of different gastro-cytoprotective effectors including total antioxidants and paraoxonase （PON 1）/arylesterase activities was measured. Results The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase （MPO） activity, IL-6 and apoptotic incidence. Conclusion Cureumin appears to have a propitious protective effect against gastric ulcer development.展开更多
Physical inactivity has been identified as one of the leading causes of many chronic diseases such as cardiovascular disease,type 2 diabetes,and obesity.Technology such as video games plays a complicated role in physi...Physical inactivity has been identified as one of the leading causes of many chronic diseases such as cardiovascular disease,type 2 diabetes,and obesity.Technology such as video games plays a complicated role in physical inactivity—much like a double-edged sword.Traditionally,video games have contributed to the epidemic of physical inactivity and have展开更多
A series of novel pyrazole oxime derivatives containing oxazole ring were designed and synthesized. The title compounds were structurally confirmed by 1H NMR, 13C NMR spectra and elemental analyses. Preliminary bioass...A series of novel pyrazole oxime derivatives containing oxazole ring were designed and synthesized. The title compounds were structurally confirmed by 1H NMR, 13C NMR spectra and elemental analyses. Preliminary bioassay results showed that some of the title compounds displayed promising fungicidal activity besides insecticidal and acaricidal activity. Particularly, compound 8c exhibited potent fungicidal activity against cucumber Pseudoperonospora cubensis beyond good insecticidal activity against Aphis craccivora and Nilaparvata lugens.展开更多
A series of novel N-（3-furan-2-yl-l-phenyl-lH-pyrazol-5-yl） amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their...A series of novel N-（3-furan-2-yl-l-phenyl-lH-pyrazol-5-yl） amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis （L） Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.展开更多
New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal car...New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma（HCT116）,prostate adenocarcinoma（PC-3） and liver carcinoma（HepG-2） using MTT cytotoxicity assay at 100 μg/mL.Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells.Whereas,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship（SAR） has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data（MS,IR,^1H NMR and ^13C NMR） and elemental analysis.展开更多
The presence of hydroxyl groups at the C4 and C7 positions in coumarin backbone has been proposed as a potential modification site for providing excellent bioactivity according to previous studies. A series of novel c...The presence of hydroxyl groups at the C4 and C7 positions in coumarin backbone has been proposed as a potential modification site for providing excellent bioactivity according to previous studies. A series of novel coumarin derivatives were rationally designed and synthesized by use of a complex catalytic system for a targeted modification at the above sites. These derivatives were assayed for nematicidal activity. As predicted, the derivatization enhanced the activity of the coumarins against five nematodes.Compounds 7b, 9a, 10 c and 11 c showed significant strong nematicidal broad spectrum activity against all tested nematodes. Compound 10 c was the most effective with the lowest LC50 values against Meloidogyne incognita（5.1 mmol/L）, Ditylenchus destructor（3.7 mmol/L）, Bursaphelenchus mucronatus（6.4 mmol/L）, Bursaphelenchus B. xylophilus（2.5 mmol/L） and Aphelenchoides besseyi（3.1 mmol/L）,respectively. A brief investigation on the structure–activity relationships（SAR） revealed that the targeted modification by a C7 hydroxyl was optimum compared with that of a C4 hydroxyl and that the coupling chain length was crucial for the nematicidal activity.展开更多
With the use of the Royal Greenwich Observatory data set of sunspot groups, an attempt is made to examine the north-south asymmetry of solar activity in the 'extended' solar cycles. It is inferred that the asy...With the use of the Royal Greenwich Observatory data set of sunspot groups, an attempt is made to examine the north-south asymmetry of solar activity in the 'extended' solar cycles. It is inferred that the asymmetry established for individual solar cycles does not extend to the 'extended' cycles.展开更多
The relationships between solar flare parameters （total importance, time duration, flare index, and flux） and sunspot activity （R z ） as well as those between geomagnetic activity （aa index） and the flare parame...The relationships between solar flare parameters （total importance, time duration, flare index, and flux） and sunspot activity （R z ） as well as those between geomagnetic activity （aa index） and the flare parameters can be well described by an integral response model with the response time scales of about 8 and 13 months, respectively. Compared with linear relationships, the correlation coefficients of the flare parameters with R z , of aa with the flare parameters, and of aa with R z based on this model have increased about 6%, 17%, and 47% on average, respectively. The time delays between the flare parameters with respect to R z , aa to the flare parameters, and aa to R z at their peaks in a solar cycle can be predicted in part by this model （82%, 47%, and 78%, respectively）. These results may be further improved when using a cosine filter with a wider window. It implies that solar flares are related to the accumulation of solar magnetic energy in the past through a time decay factor. The above results may help us to understand the mechanism of solar flares and to improve the prediction of the solar flares.展开更多
A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine su...A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine substituted amino acid methyl ester, then hydrolyzed and condensed with piperidine to produce the target compounds. In vitro cytotoxin activity test was performed against 7 target compounds with methylthiazolyldiphenyl-tetrazolium bromide（MTT）, and the results showed that compounds CZ-2, CZ-3 and CZ-5 have higher activity against human colon cancers（HT-29） and（HCT-8）, hepatocellular carcinoma（Bel-7402）, NSCLC（A549） and breast cancer（MCF-7） cells as compared with the positive control JDC-108.展开更多
Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in a...Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The ＂Monthly Report＂ is monthly compiled by the Ninth Section of Institute of Geophysics, China Earthquake Administration.展开更多
Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in ...Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The ＂Monthly Report＂ is monthly compiled by the Ninth Section of Institute of Geophysics, China Earthquake Administration.展开更多
文摘Objective To investigate the possible mechanism by which curcumio protects stomach during the acute chronic phase of gastric ulcer disease. Methods The rats were divided into four groups and fasted for 2 days with flee access to water. On the third day, the animals were fasted for a further 24 h with no access to water followed by surgery. Rats received different doses of curcumin （20, 40, and 80 mg/kg） or vehicle by oral gavage. Nineteen hours after ulcer induction, the rats were killed by decapitation. Stomach was opened along the greater curvature and ulcerative lesions were counted. Total juice acidity, neutrophils activity, mitochondrial activity, total antioxidants, paraoxonase （PON 1）/arylesterase and total peroxides were evaluated. DNA fragmentation （%） and pro-inflammatory cytokine IL-6 level were measured. The level of different gastro-cytoprotective effectors including total antioxidants and paraoxonase （PON 1）/arylesterase activities was measured. Results The anti-ulcer activity of curcumin was displayed by attenuating the different ulcerative effectors including gastric acid hyper-secretion, total peroxides, myeloperoxiase （MPO） activity, IL-6 and apoptotic incidence. Conclusion Cureumin appears to have a propitious protective effect against gastric ulcer development.
文摘Physical inactivity has been identified as one of the leading causes of many chronic diseases such as cardiovascular disease,type 2 diabetes,and obesity.Technology such as video games plays a complicated role in physical inactivity—much like a double-edged sword.Traditionally,video games have contributed to the epidemic of physical inactivity and have
基金funded by the National Natural Science Foundation of China (No.21202089)the Research Foundation of the Six People Peak of Jiangsu Province (Nos.2011-SWYY-009,2013-SWYY-013)the Technology Project Fund of Nantong City (Nos.AS2013004,CP12013002)
文摘A series of novel pyrazole oxime derivatives containing oxazole ring were designed and synthesized. The title compounds were structurally confirmed by 1H NMR, 13C NMR spectra and elemental analyses. Preliminary bioassay results showed that some of the title compounds displayed promising fungicidal activity besides insecticidal and acaricidal activity. Particularly, compound 8c exhibited potent fungicidal activity against cucumber Pseudoperonospora cubensis beyond good insecticidal activity against Aphis craccivora and Nilaparvata lugens.
基金financially supported by the National Natural Science Foundation of China (Nos.31171877,31571991,21372132)the International Science & Technology Cooperation Program of China (No.2014DFR41030)
文摘A series of novel N-（3-furan-2-yl-l-phenyl-lH-pyrazol-5-yl） amides derivatives were designed and synthesized. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. All title compounds were evaluated for their herbicidal and antifungal activities. Preliminary bioassay results indicated that the title compounds showed good to moderate herbicidal activity at 1000 mg/L. Compound 6q presented the best activity against Digitaria sanguinalis （L） Scop., Amaranthus retroflexus L. and Arabidopsis thaliana with an inhibition degree of five. Compound 6d also showed an inhibition degree of five against D. sanguinalis. In addition, at 50 mg/L, most compounds exhibited good in vitro antifungal activity against Sclerotinia sclerotiorum, with compound 6c showing over 90% antifungal activity against S. sclerotiorum and Pellicularia sasakii.
文摘New series of pyrazolo[1,5-α]pyrimidine derivatives 7a-i,11a-c and Schiff bases 13a-c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines,namely colorectal carcinoma（HCT116）,prostate adenocarcinoma（PC-3） and liver carcinoma（HepG-2） using MTT cytotoxicity assay at 100 μg/mL.Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells.Whereas,compounds 7d and 11 a showed better antitumor activity than the rest of the compounds against both cell lines.A structure-activity relationship（SAR） has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data（MS,IR,^1H NMR and ^13C NMR） and elemental analysis.
基金the National Natural Science Foundation of China(Nos.31070386,21302195 and 31300290)135 Key Cultivation Program of the Chinese Academy of Sciencesthe Province-Academy Cooperation Program of Henan Province of China(No.102106000021)for financial support
文摘The presence of hydroxyl groups at the C4 and C7 positions in coumarin backbone has been proposed as a potential modification site for providing excellent bioactivity according to previous studies. A series of novel coumarin derivatives were rationally designed and synthesized by use of a complex catalytic system for a targeted modification at the above sites. These derivatives were assayed for nematicidal activity. As predicted, the derivatization enhanced the activity of the coumarins against five nematodes.Compounds 7b, 9a, 10 c and 11 c showed significant strong nematicidal broad spectrum activity against all tested nematodes. Compound 10 c was the most effective with the lowest LC50 values against Meloidogyne incognita（5.1 mmol/L）, Ditylenchus destructor（3.7 mmol/L）, Bursaphelenchus mucronatus（6.4 mmol/L）, Bursaphelenchus B. xylophilus（2.5 mmol/L） and Aphelenchoides besseyi（3.1 mmol/L）,respectively. A brief investigation on the structure–activity relationships（SAR） revealed that the targeted modification by a C7 hydroxyl was optimum compared with that of a C4 hydroxyl and that the coupling chain length was crucial for the nematicidal activity.
基金the 973 project (G2000078408), theNational Science FOundations of China (10073019 and l9976301), the Science FOundation ofYu
文摘With the use of the Royal Greenwich Observatory data set of sunspot groups, an attempt is made to examine the north-south asymmetry of solar activity in the 'extended' solar cycles. It is inferred that the asymmetry established for individual solar cycles does not extend to the 'extended' cycles.
基金supported by the National Natural Science Foundation of China (Grant Nos.10973020, 40890161 and 10921303)the National Basic Research Program of China (973 Program, Grant No.2011CB811406)
文摘The relationships between solar flare parameters （total importance, time duration, flare index, and flux） and sunspot activity （R z ） as well as those between geomagnetic activity （aa index） and the flare parameters can be well described by an integral response model with the response time scales of about 8 and 13 months, respectively. Compared with linear relationships, the correlation coefficients of the flare parameters with R z , of aa with the flare parameters, and of aa with R z based on this model have increased about 6%, 17%, and 47% on average, respectively. The time delays between the flare parameters with respect to R z , aa to the flare parameters, and aa to R z at their peaks in a solar cycle can be predicted in part by this model （82%, 47%, and 78%, respectively）. These results may be further improved when using a cosine filter with a wider window. It implies that solar flares are related to the accumulation of solar magnetic energy in the past through a time decay factor. The above results may help us to understand the mechanism of solar flares and to improve the prediction of the solar flares.
基金Supported by the opening project of Jiangsu Key Laboratory of Biochemistry and Biotechnology of Marine Wetland(No.K2016-11)
文摘A series of antitumor compounds with indolecarbazole structure modified by amino acid and piperidine were designed and synthesized. The indolecarbazole parent nucleus was firstly synthesized, condensed with bromine substituted amino acid methyl ester, then hydrolyzed and condensed with piperidine to produce the target compounds. In vitro cytotoxin activity test was performed against 7 target compounds with methylthiazolyldiphenyl-tetrazolium bromide（MTT）, and the results showed that compounds CZ-2, CZ-3 and CZ-5 have higher activity against human colon cancers（HT-29） and（HCT-8）, hepatocellular carcinoma（Bel-7402）, NSCLC（A549） and breast cancer（MCF-7） cells as compared with the positive control JDC-108.
文摘Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The ＂Monthly Report＂ is monthly compiled by the Ninth Section of Institute of Geophysics, China Earthquake Administration.
文摘Illustration All the data in this catalog are chosen from the ＂Preliminary Seismological Report of Chinese Seismic Stations＂ （Its abbreviation is ＂Monthly Report＂）. The catalog includes the events of M≥4.7 in and near China and M≥6 all over the world. The ＂Monthly Report＂ is monthly compiled by the Ninth Section of Institute of Geophysics, China Earthquake Administration.
