Under the assumption of weak scattering , the acoustical diffraction tomographic imaging of an object can be reconstructed by using the Born (or Rytov) approximation method . When the weak scattering assumption within...Under the assumption of weak scattering , the acoustical diffraction tomographic imaging of an object can be reconstructed by using the Born (or Rytov) approximation method . When the weak scattering assumption within the medium is not satisfied the multiple ultrasound scattering must be taken into account . In this case , the reconstruction results under the first-order Born approximation will be seriously distorted . In this paper we introduce an ' intermediate object function' into the wave equation and take iterative modification in space domain and spatial frequancy domain based on Born approximation . In this way , the distorted image will be improved step by step . In order to examine the method as mentioned above , we have just tried to make computerized simulations . The initial result shows that the quality of the image reconstructed from the object under non-weak scattering may be improved significantly .展开更多
Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues.Herein,we introduce a new concept of local...Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues.Herein,we introduce a new concept of localization optoacoustic tomography(LOT)that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles.We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions.Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters,LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.展开更多
文摘Under the assumption of weak scattering , the acoustical diffraction tomographic imaging of an object can be reconstructed by using the Born (or Rytov) approximation method . When the weak scattering assumption within the medium is not satisfied the multiple ultrasound scattering must be taken into account . In this case , the reconstruction results under the first-order Born approximation will be seriously distorted . In this paper we introduce an ' intermediate object function' into the wave equation and take iterative modification in space domain and spatial frequancy domain based on Born approximation . In this way , the distorted image will be improved step by step . In order to examine the method as mentioned above , we have just tried to make computerized simulations . The initial result shows that the quality of the image reconstructed from the object under non-weak scattering may be improved significantly .
基金supported in part by the European Research Council Grant ERC-2015-CoG-682379.
文摘Localization-based imaging has revolutionized fluorescence optical microscopy and has also enabled unprecedented ultrasound images of microvascular structures in deep tissues.Herein,we introduce a new concept of localization optoacoustic tomography(LOT)that employs rapid sequential acquisition of three-dimensional optoacoustic images from flowing absorbing particles.We show that the new method enables breaking through the spatial resolution barrier of acoustic diffraction while further enhancing the visibility of structures under limited-view tomographic conditions.Given the intrinsic sensitivity of optoacoustics to multiple hemodynamic and oxygenation parameters,LOT may enable a new level of performance in studying functional and anatomical alterations of microcirculation.
