We present an accelerated method for stochastically simulating the dynamics of heterogeneous cell populations.The algorithm combines a Monte Carlo approach for simulating the biochemical kinetics in single cells with ...We present an accelerated method for stochastically simulating the dynamics of heterogeneous cell populations.The algorithm combines a Monte Carlo approach for simulating the biochemical kinetics in single cells with a constant-number Monte Carlo method for simulating the reproductive fitness and the statistical characteristics of growing cell populations.To benchmark accuracy and performance,we compare simulation results with those generated from a previously validated population dynamics algorithm.The comparison demonstrates that the accelerated method accurately simulates population dynamics with significant reductions in runtime under commonly invoked steady-state and symmetric cell division assumptions.Considering the increasing complexity of cell population models,the method is an important addition to the arsenal of existing algorithms for simulating cellular and population dynamics that enables efficient,coarse-grained exploration of parameter space.展开更多
基金supported financially by the National Science and Engineering Research Council of Canada(NSERC).
文摘We present an accelerated method for stochastically simulating the dynamics of heterogeneous cell populations.The algorithm combines a Monte Carlo approach for simulating the biochemical kinetics in single cells with a constant-number Monte Carlo method for simulating the reproductive fitness and the statistical characteristics of growing cell populations.To benchmark accuracy and performance,we compare simulation results with those generated from a previously validated population dynamics algorithm.The comparison demonstrates that the accelerated method accurately simulates population dynamics with significant reductions in runtime under commonly invoked steady-state and symmetric cell division assumptions.Considering the increasing complexity of cell population models,the method is an important addition to the arsenal of existing algorithms for simulating cellular and population dynamics that enables efficient,coarse-grained exploration of parameter space.
