Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the d...Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.展开更多
This paper presents a comprehensive evaluation on the Devonian-Carboniferous Boundary (DCB) sectionin Nanbiancun. Guilin. Guangxi on the basis of Palaeontological, biostratigraphical and sedimentarypetrological studie...This paper presents a comprehensive evaluation on the Devonian-Carboniferous Boundary (DCB) sectionin Nanbiancun. Guilin. Guangxi on the basis of Palaeontological, biostratigraphical and sedimentarypetrological studies as well as microfacies analysis. REE and trace element analysis and isotopic dating. The DCB at this section conforms to the definition of this boundary and essentially measure up the criteriaand conditions for selection of the boundary stratotype. Up to 14 fossil groups are contained in the section. Thesection presents a general biostratigraphical framework with multispecies fossils zones, assemblage zones andmultiple groups of fossils and has latent preponderant conditions for magnetostratigraphic andchronostratigraphic studies. The boundary and point occur in a persistent and continuous monofacialcarbonate succession. and the section is located in a tourist city with convenient communication, where variousfacies of DCB sections are developed. allowing the correlation within a small area. So it is an ideal candidateboundary stratotype.展开更多
Spinal cord injury（SCI）-induced bone loss represents the most severe osteoporosis with no effective treatment.Past animal studies have focused primarily on long bones at the acute stage using adolescent rodents. To ...Spinal cord injury（SCI）-induced bone loss represents the most severe osteoporosis with no effective treatment.Past animal studies have focused primarily on long bones at the acute stage using adolescent rodents. To mimic chronic SCI in human patients, we performed a comprehensive analysis of long-term structural and mechanical changes in axial and appendicular bones in adult rats after SCI. In this experiment, 4-month-old Fischer 344 male rats received a clinically relevant T13 contusion injury. Sixteen weeks later, sublesional femurs, tibiae,and L4 vertebrae, supralesional humeri, and blood were collected from these rats and additional non-surgery rats for micro-computed tomography（m CT）, micro-finite element, histology, and serum biochemical analyses.At trabecular sites, extreme losses of bone structure and mechanical competence were detected in the metaphysis of sublesional long bones after SCI, while the subchondral part of the same bones showed much milder damage. Marked reductions in bone mass and strength were also observed in sublesional L4 vertebrae but not in supralesional humeri. At cortical sites, SCI induced structural and strength damage in both sub- and supralesional long bones. These changes were accompanied by diminished osteoblast number and activity and increased osteoclast number and activity. Taken together, our study revealed site-specific effects of SCI on bone and demonstrated sustained inhibition of bone formation and elevation of bone resorption at the chronic stage of SCI.展开更多
SYNCHROTRON TECHNOLOGY AND APPLICATIONSNo.1 1 Intermediate energy light sources and the SSRF project ZHAO Zhen—Tang9 Multiple scattering approach to X-ray absorption spectroscopyM.BENFATTO,Zi—Yu WU20 Electron gun fo...SYNCHROTRON TECHNOLOGY AND APPLICATIONSNo.1 1 Intermediate energy light sources and the SSRF project ZHAO Zhen—Tang9 Multiple scattering approach to X-ray absorption spectroscopyM.BENFATTO,Zi—Yu WU20 Electron gun for SSRFSHENG Shu—Gang,LIN Guo—Qiang,GU Qiang,LI De—Ming24 A new digital beam position monitor in SSRFCHENG Wei—Xing,LIU展开更多
Four cases of primary plasma cell leukemia (PPCL) admitted to Zhongshan Hospital from 1959 to 1987 are reported with a review on additional 40 cases reported in China. Comparing with the 57 cases of multiple myeloma (...Four cases of primary plasma cell leukemia (PPCL) admitted to Zhongshan Hospital from 1959 to 1987 are reported with a review on additional 40 cases reported in China. Comparing with the 57 cases of multiple myeloma (MM) treated in our hospital, the following features were observed in PPCL: (1) The age was younger, with a mean of 45.2 years, 34.1% of the patients were under 40 years. (2) Onset was abrupt. Duration from onset to diagnosis was 2 months or less in 77% patients but never beyond 6 months. (3) 81.8% patients had liver enlargement, 59.1% splenomegaly and 61.4% sternum tenderness. (4) All patients showed marked anemia with an average hemoglobin of 65 g/L. BPC count was less than 100 × 109/L in 76% patients and WBC was more than 10×109/L in 77%. (5) Plasma cell number in the marrow was markedly increased with an average of 69%, of which the blast cells and immature forms were predominant. (6) No destruction of bones was shown on X-ray film in 68.3% patients. (7) The response to chemotherapy was poor with a total response rate of 18% and a mean survival of 2 months. All the above-mentioned clinical features were significantly different from those of MM. In addition, these two diseases were also different in cytology, cytogenetics and ultrastructure. Therefore, PPCL should be considered as a special type of acute leukemia distinct from MM. High dose of alkylating agents in combination with autologous bone marrow transplantation might improve the prognoses.展开更多
Introduction-The cervical spine is subjected to injury frequently,especially among pilots who are usually on the condition of high acceleration.Injuries of the cervical spine will be potential risk of damage to the sp...Introduction-The cervical spine is subjected to injury frequently,especially among pilots who are usually on the condition of high acceleration.Injuries of the cervical spine will be potential risk of damage to the spinal cord,which could be result in life threatening展开更多
ZTE Corporation, a leading global provider of telecommunications equipment and network solutions, unveiled its 3G strategy to make life "easier, freer and trendier" for consumers by combining Telecom and IT ...ZTE Corporation, a leading global provider of telecommunications equipment and network solutions, unveiled its 3G strategy to make life "easier, freer and trendier" for consumers by combining Telecom and IT with 3G展开更多
The Chinese government officially resumed its exercise of sovereignty over Hong Kong on July 1, 1997. On this historic occasion, the China National Machinery Import and Export Corporation officially renamed itself as ...The Chinese government officially resumed its exercise of sovereignty over Hong Kong on July 1, 1997. On this historic occasion, the China National Machinery Import and Export Corporation officially renamed itself as the China Machinery Import and Export Group Corporation, with the approval of the relevant department of the state, and moved into its new office building. The change of name marks the progress it has achieved in a the course of exploring the establishment of a modern enterprise system. It was designated by the State Council in 1994 as one of the first group of 100 enterprises in China to introduce the modern enterprise system on a trial basis.In particular since 1995, when its展开更多
The Denglou Cape, southwest of the Leizhou Peninsula, is the most typical tropical coast in the continent of China.The coastal geomorphic development basics of the geology and Quaternary environment change are discus...The Denglou Cape, southwest of the Leizhou Peninsula, is the most typical tropical coast in the continent of China.The coastal geomorphic development basics of the geology and Quaternary environment change are discussed. Aerial photograph interpretation with fieldwork is applied to draw the outlines of geomorphic types. Based on the investigative data, the exogenic forces and marine organism conditions concerning tropical coast development in the area are expounded, and coastal dynamo-deposition geomorphic bodies are analysed, mainly with sea cliff-abrasion platform,barrier-lagoon system, modern beach, coral reef and mangrove tidal flat, and the general process of coastal evolution at this area, as well as coastline changes since middle Holocene transgression.展开更多
’Adhering to the establishment of the system of socialist rule of law with Chinese characteristics’is an original and contemporary concept and theory proposed by General Secretary Xi Jinping,and is the core essence ...’Adhering to the establishment of the system of socialist rule of law with Chinese characteristics’is an original and contemporary concept and theory proposed by General Secretary Xi Jinping,and is the core essence of Xi Jinping Thought on the Rule of Law.Establishing a system of socialist rule of law with Chinese characteristics is not only the general goal of overall law-based governance,but also the general starting point for overall law-based governance,and it is also the only way to establish a country of socialist rule of law.General Secretary Xi Jinping incisively discussed the scientific connotation and key tasks of establishing a system of socialist rule of law with Chinese characteristics,that is,under the leadership of the Communist Party of China,we need to uphold the socialist system with Chinese characteristics,put into practice the theory of socialist rule of law with Chinese characteristics,form a complete system of laws and regulations,a highly effective enforcement system of the rule of law,a stringent supervision system of the rule of law,and a robust guarantee system of the rule of law,and form a sound system of intra-Party regulations.展开更多
On May 9,a signing ceremony of a comprehensive strategic cooperation framework agreement was held at Aluminum Corporation of China headquarters with Bayannur City,marking the formal establishment of a strategic partne...On May 9,a signing ceremony of a comprehensive strategic cooperation framework agreement was held at Aluminum Corporation of China headquarters with Bayannur City,marking the formal establishment of a strategic partnership between the two parties.展开更多
Foreword Since the 18th National Congress of the Communist Party of China(CPC)held in 2012,the CPC Central Committee with Comrade Xi Jinping at its core has practiced a people-centered approach to development.With a s...Foreword Since the 18th National Congress of the Communist Party of China(CPC)held in 2012,the CPC Central Committee with Comrade Xi Jinping at its core has practiced a people-centered approach to development.With a strategic vision to rejuvenate the Chinese nation,and to ensure that the Xizang Autonomous Region will realize moderate prosperity and modernization together with the rest of the country,the CPC Central Committee has attached great importance to the development of Xizang and focused its attention on the people in the region.The CPC Central Committee.held the sixth and seventh national meetings on Xizang in 2015 and 2020 respectively,at which it established the guiding principles,overall requirements and priority tasks,pointing the way to lasting stability and quality development,meeting the people's aspirations for a better life,and realizing socialist modernization in the region.展开更多
基金supported by NIH grants AR055915 and AR054465 to DC
文摘Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.
文摘This paper presents a comprehensive evaluation on the Devonian-Carboniferous Boundary (DCB) sectionin Nanbiancun. Guilin. Guangxi on the basis of Palaeontological, biostratigraphical and sedimentarypetrological studies as well as microfacies analysis. REE and trace element analysis and isotopic dating. The DCB at this section conforms to the definition of this boundary and essentially measure up the criteriaand conditions for selection of the boundary stratotype. Up to 14 fossil groups are contained in the section. Thesection presents a general biostratigraphical framework with multispecies fossils zones, assemblage zones andmultiple groups of fossils and has latent preponderant conditions for magnetostratigraphic andchronostratigraphic studies. The boundary and point occur in a persistent and continuous monofacialcarbonate succession. and the section is located in a tourist city with convenient communication, where variousfacies of DCB sections are developed. allowing the correlation within a small area. So it is an ideal candidateboundary stratotype.
基金supported by the National Institutes of Health(R01DK095803 to LQ, 1K08HD049598 to YZ)Penn Center for Musculoskeletal Disorders P30AR050950(NIAMS/NIH)+1 种基金ASBMR Junior Faculty Osteoporosis Basic Research Award(to LQ)NIH/NIAMS R03-AR065145(to XSL)
文摘Spinal cord injury（SCI）-induced bone loss represents the most severe osteoporosis with no effective treatment.Past animal studies have focused primarily on long bones at the acute stage using adolescent rodents. To mimic chronic SCI in human patients, we performed a comprehensive analysis of long-term structural and mechanical changes in axial and appendicular bones in adult rats after SCI. In this experiment, 4-month-old Fischer 344 male rats received a clinically relevant T13 contusion injury. Sixteen weeks later, sublesional femurs, tibiae,and L4 vertebrae, supralesional humeri, and blood were collected from these rats and additional non-surgery rats for micro-computed tomography（m CT）, micro-finite element, histology, and serum biochemical analyses.At trabecular sites, extreme losses of bone structure and mechanical competence were detected in the metaphysis of sublesional long bones after SCI, while the subchondral part of the same bones showed much milder damage. Marked reductions in bone mass and strength were also observed in sublesional L4 vertebrae but not in supralesional humeri. At cortical sites, SCI induced structural and strength damage in both sub- and supralesional long bones. These changes were accompanied by diminished osteoblast number and activity and increased osteoclast number and activity. Taken together, our study revealed site-specific effects of SCI on bone and demonstrated sustained inhibition of bone formation and elevation of bone resorption at the chronic stage of SCI.
文摘SYNCHROTRON TECHNOLOGY AND APPLICATIONSNo.1 1 Intermediate energy light sources and the SSRF project ZHAO Zhen—Tang9 Multiple scattering approach to X-ray absorption spectroscopyM.BENFATTO,Zi—Yu WU20 Electron gun for SSRFSHENG Shu—Gang,LIN Guo—Qiang,GU Qiang,LI De—Ming24 A new digital beam position monitor in SSRFCHENG Wei—Xing,LIU
文摘Four cases of primary plasma cell leukemia (PPCL) admitted to Zhongshan Hospital from 1959 to 1987 are reported with a review on additional 40 cases reported in China. Comparing with the 57 cases of multiple myeloma (MM) treated in our hospital, the following features were observed in PPCL: (1) The age was younger, with a mean of 45.2 years, 34.1% of the patients were under 40 years. (2) Onset was abrupt. Duration from onset to diagnosis was 2 months or less in 77% patients but never beyond 6 months. (3) 81.8% patients had liver enlargement, 59.1% splenomegaly and 61.4% sternum tenderness. (4) All patients showed marked anemia with an average hemoglobin of 65 g/L. BPC count was less than 100 × 109/L in 76% patients and WBC was more than 10×109/L in 77%. (5) Plasma cell number in the marrow was markedly increased with an average of 69%, of which the blast cells and immature forms were predominant. (6) No destruction of bones was shown on X-ray film in 68.3% patients. (7) The response to chemotherapy was poor with a total response rate of 18% and a mean survival of 2 months. All the above-mentioned clinical features were significantly different from those of MM. In addition, these two diseases were also different in cytology, cytogenetics and ultrastructure. Therefore, PPCL should be considered as a special type of acute leukemia distinct from MM. High dose of alkylating agents in combination with autologous bone marrow transplantation might improve the prognoses.
文摘Introduction-The cervical spine is subjected to injury frequently,especially among pilots who are usually on the condition of high acceleration.Injuries of the cervical spine will be potential risk of damage to the spinal cord,which could be result in life threatening
文摘ZTE Corporation, a leading global provider of telecommunications equipment and network solutions, unveiled its 3G strategy to make life "easier, freer and trendier" for consumers by combining Telecom and IT with 3G
文摘The Chinese government officially resumed its exercise of sovereignty over Hong Kong on July 1, 1997. On this historic occasion, the China National Machinery Import and Export Corporation officially renamed itself as the China Machinery Import and Export Group Corporation, with the approval of the relevant department of the state, and moved into its new office building. The change of name marks the progress it has achieved in a the course of exploring the establishment of a modern enterprise system. It was designated by the State Council in 1994 as one of the first group of 100 enterprises in China to introduce the modern enterprise system on a trial basis.In particular since 1995, when its
文摘The Denglou Cape, southwest of the Leizhou Peninsula, is the most typical tropical coast in the continent of China.The coastal geomorphic development basics of the geology and Quaternary environment change are discussed. Aerial photograph interpretation with fieldwork is applied to draw the outlines of geomorphic types. Based on the investigative data, the exogenic forces and marine organism conditions concerning tropical coast development in the area are expounded, and coastal dynamo-deposition geomorphic bodies are analysed, mainly with sea cliff-abrasion platform,barrier-lagoon system, modern beach, coral reef and mangrove tidal flat, and the general process of coastal evolution at this area, as well as coastline changes since middle Holocene transgression.
文摘’Adhering to the establishment of the system of socialist rule of law with Chinese characteristics’is an original and contemporary concept and theory proposed by General Secretary Xi Jinping,and is the core essence of Xi Jinping Thought on the Rule of Law.Establishing a system of socialist rule of law with Chinese characteristics is not only the general goal of overall law-based governance,but also the general starting point for overall law-based governance,and it is also the only way to establish a country of socialist rule of law.General Secretary Xi Jinping incisively discussed the scientific connotation and key tasks of establishing a system of socialist rule of law with Chinese characteristics,that is,under the leadership of the Communist Party of China,we need to uphold the socialist system with Chinese characteristics,put into practice the theory of socialist rule of law with Chinese characteristics,form a complete system of laws and regulations,a highly effective enforcement system of the rule of law,a stringent supervision system of the rule of law,and a robust guarantee system of the rule of law,and form a sound system of intra-Party regulations.
文摘On May 9,a signing ceremony of a comprehensive strategic cooperation framework agreement was held at Aluminum Corporation of China headquarters with Bayannur City,marking the formal establishment of a strategic partnership between the two parties.
文摘Foreword Since the 18th National Congress of the Communist Party of China(CPC)held in 2012,the CPC Central Committee with Comrade Xi Jinping at its core has practiced a people-centered approach to development.With a strategic vision to rejuvenate the Chinese nation,and to ensure that the Xizang Autonomous Region will realize moderate prosperity and modernization together with the rest of the country,the CPC Central Committee has attached great importance to the development of Xizang and focused its attention on the people in the region.The CPC Central Committee.held the sixth and seventh national meetings on Xizang in 2015 and 2020 respectively,at which it established the guiding principles,overall requirements and priority tasks,pointing the way to lasting stability and quality development,meeting the people's aspirations for a better life,and realizing socialist modernization in the region.
