To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who prelimi...To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who preliminarily developed high altitude cerebral edema (HACE) and then ARDS occurred at an altitude of 4 500 m. After an initial emergency treatment on high mountains,all the patients were rapidly transported to a hospital at a lower altitude of 2 808 m. The right cardiac catheterizations were carried out within 5 h after hospitalized. The monitoring hemodynamics and oxygen dynamics were studied via a thermodilution Swan-Gaze catheter. The results showed that before treatments at the beginning of monitoring,there presented a significant pulmonary artery hypertension with a decreased cardiac function,and a lower oxygen metabolism in all the 8 patients. However,after some effective treatments,including mechanical ventilation and using dexamethasone,furosemide,etc,four days later the result of a repeated monitoring showed that their pulmonary artery pressure had been decreased with an improved cardiac function with all the oxygen metabolic indexes increased significantly. Our studies suggested that performing monitoring hemodynamics in patients with ARDS secondary to HAPE will define the clinical therapeutic measures which will benefit the outcome.展开更多
Effect of multiple respiratory gas monitoring (MRGM ) on inspiredconcentration of oxygen in circult system during closed anesthesia was studied in 5l adult patients scheduled for abdominal surgery. Required flow rate ...Effect of multiple respiratory gas monitoring (MRGM ) on inspiredconcentration of oxygen in circult system during closed anesthesia was studied in 5l adult patients scheduled for abdominal surgery. Required flow rate of fresh oxygen (OFR), inspired oxygen concentration (FiO2 ) and oxygen saturation of pulse oximeter (SpO2) were measured continu0usly. Patients were equally divided into three groups at randorn, group C (no MRGN used ), group M, (using MRGM with its tail gas returned to circuit system), group M2 (using MRGM without tail gas returned ). The results revealed that during 180 min of closed anesthesia, OFR required in group C and M, were about 200-230 ml/min, and in group M, it was ab0ut 400 ml/min. In group C FiO2 decreased by about 10 % after 60 min of closed anesthesia (P<0. 01, 60 min vs 0 min ) and then stayed stable at this level. In group M,, FiO2 decreased by 16% at 60 min and 34 % at 180 min and the decrease was significantly greater than that in gr0up C (P<0. 01). In group Me, FiO2 remained c0nstant during closed anesthesia, which was much high(Jr than those in group C and M,. The tail gas of Capnomac Ultima MRGM contained less oxygen than its sample gas drawn fr0m circuit system simuItaneously.展开更多
Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain an...Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose detection.Microneedle technology is less invasive,yet microneedle adhesion with skin tissue is limited.In this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in vivo.The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle array.Due to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into skin.The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation state.Finally,the MASA was integrated into a monitoring system using custom circuitry.This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.展开更多
In the development of modern science and technology, the demand for multi-functional electronic equipment is increasing for people. Now, the multi-functional electronic bracelet is a hot term in all walks of life, whe...In the development of modern science and technology, the demand for multi-functional electronic equipment is increasing for people. Now, the multi-functional electronic bracelet is a hot term in all walks of life, whether it is business elites, energetic student groups, or health-conscious middle-aged and elderly people, will be the champion of the multi-functional electronic bracelet crowd. This paper adopts STM32F103ZET6 as the core design of multi-functional electronic bracelet. Electronic bracelet mainly through STM32 control and processing DS18B20 temperature sensor, MAX30102 sensor, RTC clock, to achieve heart rate and blood oxygen monitoring, real-time clock display, alarm clock reminder and other functions, which will be displayed on an OLED.展开更多
In recent years there has been significant developments in photosensitizers(PSs), light sources and light delivery systems that have allowed decreasing the treatment time and skin phototoxicity resulting in more frequ...In recent years there has been significant developments in photosensitizers(PSs), light sources and light delivery systems that have allowed decreasing the treatment time and skin phototoxicity resulting in more frequent use of photodynamic therapy(PDT) in the clinical settings. Compared to standard treatment approaches such as chemo-radiation and surgery, PDT has much reduced morbidity for head and neck malignancies and is becoming an alternative treatment option. It can be used as an adjunct therapy to other treatment modalities without any additive cumulative side effects. Surface illumination can be an option for pre-malignant and early-stage malignancies while interstitial treatment is for debulking of thick tumors in the head and neck region. PDT can achieve equivalent or greater efficacy in treating head and neck malignancies, suggesting that it may be considered as a first line therapy in the future. Despite progressive development, clinical PDT needs improvement in several topics for wider acceptance including standardization of protocols that involve the same administrated light and PS doses and establishing quantitative tools for PDT dosimetry planning and response monitoring. Quantitative measures such as optical parameters, PS concentration, tissueoxygenation and blood flow are essential for accurate PDT dosimetry as well as PDT response monitoring and assessing therapy outcome. Unlike conventional imaging modalities like magnetic resonance imaging, novel optical imaging techniques can quantify PDT-related parameters without any contrast agent administration and enable real-time assessment during PDT for providing fast feedback to clinicians. Ongoing developments in optical imaging offer the promise of optimization of PDT protocols with improved outcomes.展开更多
A strain of yeast, which can endure high osmotic pressure, is employed for the sensitive material of the microbial BOD sensor. Two immobilization methods are used, I.e. Calcium alginate gel be ads and PV A gel beads. ...A strain of yeast, which can endure high osmotic pressure, is employed for the sensitive material of the microbial BOD sensor. Two immobilization methods are used, I.e. Calcium alginate gel be ads and PV A gel beads. The results show that the PVA gel beads is better. The influences of osmosis and heavy metal ions on the yeast entrapped in the PVA gel beads are also studied in the experiment.展开更多
The vital role of anthocyanins in <i>Hibiscus sabdariffa</i> L. is now known to most consumers. The richness of anthocyanins in antioxidants, vitamin C, minerals, etc., provides <i>Hibiscus</i>...The vital role of anthocyanins in <i>Hibiscus sabdariffa</i> L. is now known to most consumers. The richness of anthocyanins in antioxidants, vitamin C, minerals, etc., provides <i>Hibiscus</i> juice with proven nutritional qualities. The health requirements of recent years have made food products with added preservatives or processed at high temperatures less popular, thus explaining the new <span>orientations towards innovative and interdisciplinary technologies. Antho</span>cyanins from <i>Hibiscus sabdariffa</i> L. are, however, sensitive to degradation factors such as temperature, light, enzymes and also oxygen. The instability of <span>anthocyanins has long been a subject of research using classic techniques</span> such as heat treatment, the results of which are often limited by the rapid degradation and above all the destruction of the nutritional and organoleptic qualities of the product. Oxygen dissolved in juices is so far treated by bubbling with an inert gas or by adding other molecules such as preservatives which can cause a lot of health damage. The electrochemical approach is a <span>new stabilisation technique that reduces the dissolved oxygen in the juice</span>, cold and without the addition of other molecules. The electrolysis of <i>Hibiscus</i> juice was carried out by noble electrodes (Platinum and Stainless Steel) with a well-<span>characterised Time/Potential or Time/Intensity couple. The electroreduced</span> samples and the control were then stored at 4°C, 25°C and 37°C for more than 6 months. Monitoring of anthocyanins in the first month, of the samples and the control, showed a significant difference of 10% between the electroreduced extract and the untreated control at 37°C, which had previously been problematic for the heat treatment and even for the other membrane techniques. Oxygen reduction on the platinum electrode/ECS allowed the retention of more than 10% of anthocyanins after 4 weeks of storage at 25°C and 37°C. At 4°C, a significant difference of 5% between the electro-reduced <i>Hibiscus</i> juice and the control was maintained until the fifth month of storage <span>with the 1/5 ratio (calyx/water). Non-significant losses in anthocyanin (10</span> mg/l), for the juice with reduced dissolved oxygen, were noted for the 1/5 and 1/15 ratios during the first month of storage at 4°C against 24 mg/l of significant losses for the 1/20 ratio. However, the untreated control showed significant losses for the ratios 1/20, 1/15 and 1/5. Oxygen dissolved in the juice therefore considerably degrades the anthocyanins of <i>Hibiscus sabdariffa</i> L<span style="font-size:10.0pt;font-family:;" "="">.</span><span style="font-size:10.0pt;font-family:;" "=""> from the first month of storage at 4°C.</span>展开更多
Peripheral oxygenation level (SpO<sub>2</sub>) can provide vital information on body functions. Continuous monitoring facilitates effective diagnosis and treatment and can even be lifesaving. Clinical devi...Peripheral oxygenation level (SpO<sub>2</sub>) can provide vital information on body functions. Continuous monitoring facilitates effective diagnosis and treatment and can even be lifesaving. Clinical device monitor SpO<sub>2</sub> using a clip, and measure light transmission through the tissue. This method limits the body locations of the clip’s placement and is sensitive to body movement, which hampers continuous SpO<sub>2</sub> monitoring during wakefulness or sleep, thus decreasing its usability in clinics and its accessibility in homecare usage. We developed a portable, wireless, flat and low cost prototype for continuous monitoring of SpO<sub>2</sub> that overcomes those limitations. The prototype enables convenient measurement in larger variety of body locations by spectrophotometric measurements of changes in the optical reflectance unlike other device that measure absorption through the tissue. The original design and signal processing enable reliable signal acquisition, synchronization and control. An Android’s application was developed to provide a user friendly interface for results display on smartphones. The prototype’s measurements were compared to commercial device that simultaneously measured heart rate frequency, transcutaneous oxygen tension (tcPO<sub>2</sub>) and SpO<sub>2</sub>. The prototype’s measurements accurately reflected changes caused by blood pulses, were correlated to the heart rate, and were sensitive to changes in oxygen saturation. Excellent real time behavior and synchronization were demonstrated between the hardware and smartphone software. Our prototype thus enables convenient SpO<sub>2</sub> measurement over the entire body, while maintaining accuracy comparable to commercial device. Its smartphone application enables accessible and understandable results display to patients, care-givers and healthcare professionals. The application’s display and alert calibration flexibility facilitates the prototype’s usage in changing medical requirements and for various disease and conditions. A device based on this prototype can monitor continuously and accurately patients’ SpO<sub>2</sub> without limiting their everyday activities or disturbing their sleep and can thus significantly im-prove their medical care in both clinics and home.展开更多
基金"973"National Key Basic Research and Development Program(No.2012CB518202)Project of Qinghai Development of Science and Technology(No.2011-N-150)
文摘To study monitoring hemodynamics and oxygen dynamics of adult respiratory distress syndrome (ARDS) secondary to high altitude pulmonary edema (HAPE),we performed clinic and laboratory studies in 8 patients who preliminarily developed high altitude cerebral edema (HACE) and then ARDS occurred at an altitude of 4 500 m. After an initial emergency treatment on high mountains,all the patients were rapidly transported to a hospital at a lower altitude of 2 808 m. The right cardiac catheterizations were carried out within 5 h after hospitalized. The monitoring hemodynamics and oxygen dynamics were studied via a thermodilution Swan-Gaze catheter. The results showed that before treatments at the beginning of monitoring,there presented a significant pulmonary artery hypertension with a decreased cardiac function,and a lower oxygen metabolism in all the 8 patients. However,after some effective treatments,including mechanical ventilation and using dexamethasone,furosemide,etc,four days later the result of a repeated monitoring showed that their pulmonary artery pressure had been decreased with an improved cardiac function with all the oxygen metabolic indexes increased significantly. Our studies suggested that performing monitoring hemodynamics in patients with ARDS secondary to HAPE will define the clinical therapeutic measures which will benefit the outcome.
文摘Effect of multiple respiratory gas monitoring (MRGM ) on inspiredconcentration of oxygen in circult system during closed anesthesia was studied in 5l adult patients scheduled for abdominal surgery. Required flow rate of fresh oxygen (OFR), inspired oxygen concentration (FiO2 ) and oxygen saturation of pulse oximeter (SpO2) were measured continu0usly. Patients were equally divided into three groups at randorn, group C (no MRGN used ), group M, (using MRGM with its tail gas returned to circuit system), group M2 (using MRGM without tail gas returned ). The results revealed that during 180 min of closed anesthesia, OFR required in group C and M, were about 200-230 ml/min, and in group M, it was ab0ut 400 ml/min. In group C FiO2 decreased by about 10 % after 60 min of closed anesthesia (P<0. 01, 60 min vs 0 min ) and then stayed stable at this level. In group M,, FiO2 decreased by 16% at 60 min and 34 % at 180 min and the decrease was significantly greater than that in gr0up C (P<0. 01). In group Me, FiO2 remained c0nstant during closed anesthesia, which was much high(Jr than those in group C and M,. The tail gas of Capnomac Ultima MRGM contained less oxygen than its sample gas drawn fr0m circuit system simuItaneously.
基金This work was financially supported by the National Key R&D Program of China(Nos.2021YFF1200700 and 2021YFA0911100)the National Natural Science Foundation of China(Nos.32171399,32171456,and T2225010)+6 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2021A1515012261)the Science and Technology Program of Guangzhou,China(No.202103000076)the Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(No.22dfx02),and Pazhou Lab,Guangzhou(No.PZL2021KF0003)FML would like to thank the National Natural Science Foundation of China(Nos.32171335 and 31900954)JL would like to thank the National Natural Science Foundation of China(No.62105380)the China Postdoctoral Science Foundation(No.2021M693686)QQOY would like to thank the China Postdoctoral Science Foundation(No.2022M713645).
文摘Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose detection.Microneedle technology is less invasive,yet microneedle adhesion with skin tissue is limited.In this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in vivo.The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle array.Due to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into skin.The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation state.Finally,the MASA was integrated into a monitoring system using custom circuitry.This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.
文摘In the development of modern science and technology, the demand for multi-functional electronic equipment is increasing for people. Now, the multi-functional electronic bracelet is a hot term in all walks of life, whether it is business elites, energetic student groups, or health-conscious middle-aged and elderly people, will be the champion of the multi-functional electronic bracelet crowd. This paper adopts STM32F103ZET6 as the core design of multi-functional electronic bracelet. Electronic bracelet mainly through STM32 control and processing DS18B20 temperature sensor, MAX30102 sensor, RTC clock, to achieve heart rate and blood oxygen monitoring, real-time clock display, alarm clock reminder and other functions, which will be displayed on an OLED.
基金Supported by RPCI Startup Grant(P30CA16056)NCI CA55791
文摘In recent years there has been significant developments in photosensitizers(PSs), light sources and light delivery systems that have allowed decreasing the treatment time and skin phototoxicity resulting in more frequent use of photodynamic therapy(PDT) in the clinical settings. Compared to standard treatment approaches such as chemo-radiation and surgery, PDT has much reduced morbidity for head and neck malignancies and is becoming an alternative treatment option. It can be used as an adjunct therapy to other treatment modalities without any additive cumulative side effects. Surface illumination can be an option for pre-malignant and early-stage malignancies while interstitial treatment is for debulking of thick tumors in the head and neck region. PDT can achieve equivalent or greater efficacy in treating head and neck malignancies, suggesting that it may be considered as a first line therapy in the future. Despite progressive development, clinical PDT needs improvement in several topics for wider acceptance including standardization of protocols that involve the same administrated light and PS doses and establishing quantitative tools for PDT dosimetry planning and response monitoring. Quantitative measures such as optical parameters, PS concentration, tissueoxygenation and blood flow are essential for accurate PDT dosimetry as well as PDT response monitoring and assessing therapy outcome. Unlike conventional imaging modalities like magnetic resonance imaging, novel optical imaging techniques can quantify PDT-related parameters without any contrast agent administration and enable real-time assessment during PDT for providing fast feedback to clinicians. Ongoing developments in optical imaging offer the promise of optimization of PDT protocols with improved outcomes.
文摘A strain of yeast, which can endure high osmotic pressure, is employed for the sensitive material of the microbial BOD sensor. Two immobilization methods are used, I.e. Calcium alginate gel be ads and PV A gel beads. The results show that the PVA gel beads is better. The influences of osmosis and heavy metal ions on the yeast entrapped in the PVA gel beads are also studied in the experiment.
文摘The vital role of anthocyanins in <i>Hibiscus sabdariffa</i> L. is now known to most consumers. The richness of anthocyanins in antioxidants, vitamin C, minerals, etc., provides <i>Hibiscus</i> juice with proven nutritional qualities. The health requirements of recent years have made food products with added preservatives or processed at high temperatures less popular, thus explaining the new <span>orientations towards innovative and interdisciplinary technologies. Antho</span>cyanins from <i>Hibiscus sabdariffa</i> L. are, however, sensitive to degradation factors such as temperature, light, enzymes and also oxygen. The instability of <span>anthocyanins has long been a subject of research using classic techniques</span> such as heat treatment, the results of which are often limited by the rapid degradation and above all the destruction of the nutritional and organoleptic qualities of the product. Oxygen dissolved in juices is so far treated by bubbling with an inert gas or by adding other molecules such as preservatives which can cause a lot of health damage. The electrochemical approach is a <span>new stabilisation technique that reduces the dissolved oxygen in the juice</span>, cold and without the addition of other molecules. The electrolysis of <i>Hibiscus</i> juice was carried out by noble electrodes (Platinum and Stainless Steel) with a well-<span>characterised Time/Potential or Time/Intensity couple. The electroreduced</span> samples and the control were then stored at 4°C, 25°C and 37°C for more than 6 months. Monitoring of anthocyanins in the first month, of the samples and the control, showed a significant difference of 10% between the electroreduced extract and the untreated control at 37°C, which had previously been problematic for the heat treatment and even for the other membrane techniques. Oxygen reduction on the platinum electrode/ECS allowed the retention of more than 10% of anthocyanins after 4 weeks of storage at 25°C and 37°C. At 4°C, a significant difference of 5% between the electro-reduced <i>Hibiscus</i> juice and the control was maintained until the fifth month of storage <span>with the 1/5 ratio (calyx/water). Non-significant losses in anthocyanin (10</span> mg/l), for the juice with reduced dissolved oxygen, were noted for the 1/5 and 1/15 ratios during the first month of storage at 4°C against 24 mg/l of significant losses for the 1/20 ratio. However, the untreated control showed significant losses for the ratios 1/20, 1/15 and 1/5. Oxygen dissolved in the juice therefore considerably degrades the anthocyanins of <i>Hibiscus sabdariffa</i> L<span style="font-size:10.0pt;font-family:;" "="">.</span><span style="font-size:10.0pt;font-family:;" "=""> from the first month of storage at 4°C.</span>
文摘Peripheral oxygenation level (SpO<sub>2</sub>) can provide vital information on body functions. Continuous monitoring facilitates effective diagnosis and treatment and can even be lifesaving. Clinical device monitor SpO<sub>2</sub> using a clip, and measure light transmission through the tissue. This method limits the body locations of the clip’s placement and is sensitive to body movement, which hampers continuous SpO<sub>2</sub> monitoring during wakefulness or sleep, thus decreasing its usability in clinics and its accessibility in homecare usage. We developed a portable, wireless, flat and low cost prototype for continuous monitoring of SpO<sub>2</sub> that overcomes those limitations. The prototype enables convenient measurement in larger variety of body locations by spectrophotometric measurements of changes in the optical reflectance unlike other device that measure absorption through the tissue. The original design and signal processing enable reliable signal acquisition, synchronization and control. An Android’s application was developed to provide a user friendly interface for results display on smartphones. The prototype’s measurements were compared to commercial device that simultaneously measured heart rate frequency, transcutaneous oxygen tension (tcPO<sub>2</sub>) and SpO<sub>2</sub>. The prototype’s measurements accurately reflected changes caused by blood pulses, were correlated to the heart rate, and were sensitive to changes in oxygen saturation. Excellent real time behavior and synchronization were demonstrated between the hardware and smartphone software. Our prototype thus enables convenient SpO<sub>2</sub> measurement over the entire body, while maintaining accuracy comparable to commercial device. Its smartphone application enables accessible and understandable results display to patients, care-givers and healthcare professionals. The application’s display and alert calibration flexibility facilitates the prototype’s usage in changing medical requirements and for various disease and conditions. A device based on this prototype can monitor continuously and accurately patients’ SpO<sub>2</sub> without limiting their everyday activities or disturbing their sleep and can thus significantly im-prove their medical care in both clinics and home.
