In this letter,we are going to use a geometrical approach to describe the free energy of DNA structures.The exact solutions of the equilibrium shape equations in a general WLC model for DNA forms by using the Feoli...In this letter,we are going to use a geometrical approach to describe the free energy of DNA structures.The exact solutions of the equilibrium shape equations in a general WLC model for DNA forms by using the Feoli's formalism [A.Feoli,et al.,Nucl.Phys.B 705(2005) 577] are studied.Then,the free energy of transition between Band Z-DNA is calculated in this formalism.展开更多
将嗅觉神经系统刺激、响应的Winner Less Competition(WLC)模型应用到视觉通道的视网膜神经元网络的计算之中,研究视网膜神经元的电位发放特性。通过数值实验,发现视网膜神经元的电位发放与生理实验的结果相近,得出WLC模型能够用于视觉...将嗅觉神经系统刺激、响应的Winner Less Competition(WLC)模型应用到视觉通道的视网膜神经元网络的计算之中,研究视网膜神经元的电位发放特性。通过数值实验,发现视网膜神经元的电位发放与生理实验的结果相近,得出WLC模型能够用于视觉通道计算研究的结论,并分析了视网膜神经元网络中神经节神经元电位发放的ISI,讨论了该网络模型的动力学性质。展开更多
By the so-called wormlike chain （WLC） model in polymer physics envision- ing an isotropic rod that is continuously flexible, the force-extension relations of semi- flexible polymer chains strongly constrained by var...By the so-called wormlike chain （WLC） model in polymer physics envision- ing an isotropic rod that is continuously flexible, the force-extension relations of semi- flexible polymer chains strongly constrained by various confinements are theoretically investigated, including a slab-like confinement where the polymer chains are sandwiched between two parallel impenetrable walls, and a capped nanochannel confinement with a circular or rectangular cross-section where the chains are bounded in three directions. The Brownian dynamics （BD） simulations based on the generalized bead-rod （GBR） model are performed to verify the theoretical predictions.展开更多
Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical v...Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical value.In order to fix this problem,we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo algorithm.The simulation results not only address Hari Shroff’s experiment difficulty reasonably,but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko[Phys.Rev.Lett.93(2004)].展开更多
基金supported in part by the Islamic Azad University-Kashan Branch
文摘In this letter,we are going to use a geometrical approach to describe the free energy of DNA structures.The exact solutions of the equilibrium shape equations in a general WLC model for DNA forms by using the Feoli's formalism [A.Feoli,et al.,Nucl.Phys.B 705(2005) 577] are studied.Then,the free energy of transition between Band Z-DNA is calculated in this formalism.
文摘将嗅觉神经系统刺激、响应的Winner Less Competition(WLC)模型应用到视觉通道的视网膜神经元网络的计算之中,研究视网膜神经元的电位发放特性。通过数值实验,发现视网膜神经元的电位发放与生理实验的结果相近,得出WLC模型能够用于视觉通道计算研究的结论,并分析了视网膜神经元网络中神经节神经元电位发放的ISI,讨论了该网络模型的动力学性质。
基金supported the National Natural Science Foundation of China(Nos.11032006,11072094,and11121202)the Ph.D.Program Foundation of Ministry of Education of China(No.20100211110022)+1 种基金the National Key Project of Magneto-Constrained Fusion Energy Development Program of China(No.2013GB110002)the Fundamental Research Funds for the Central Universities(No.lzujbky2013-1)
文摘By the so-called wormlike chain （WLC） model in polymer physics envision- ing an isotropic rod that is continuously flexible, the force-extension relations of semi- flexible polymer chains strongly constrained by various confinements are theoretically investigated, including a slab-like confinement where the polymer chains are sandwiched between two parallel impenetrable walls, and a capped nanochannel confinement with a circular or rectangular cross-section where the chains are bounded in three directions. The Brownian dynamics （BD） simulations based on the generalized bead-rod （GBR） model are performed to verify the theoretical predictions.
基金This research was supported by the Young Investigator Award received by Yan in 2006 and the Foundation for the Visiting PhD Candidate of the Chinese Academy of Science received by Liu in 2006Liu is also supported by the Innovation Foundation for Graduate Students of Guizhou University(2007022).
文摘Recently Hari Shroff and his collaborators[Nano Letters 5(2005)]developed a nanoscopic force sensor,but the force which they measured in their single molecular experiment was much lower than the theoretical critical value.In order to fix this problem,we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo algorithm.The simulation results not only address Hari Shroff’s experiment difficulty reasonably,but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko[Phys.Rev.Lett.93(2004)].
