Polycystic ovary syndrome(PCOS)is a prevalent endocrine disorder that poses a significant threat to women’s health.As a classical traditional Chinese medicine(TCM)formulation,Guizhi-Fuling Wan(GFW)has a good applicat...Polycystic ovary syndrome(PCOS)is a prevalent endocrine disorder that poses a significant threat to women’s health.As a classical traditional Chinese medicine(TCM)formulation,Guizhi-Fuling Wan(GFW)has a good application prospect in the complementary treatment of PCOS.This study aimed to systematically summarize the traditional efficacy and pharmacological composition of the Chinese medicines contained in GFW and evaluate the clinical efficacy and safety of their active ingredients in the complementary treatment of PCOS.A growing number of studies have demonstrated that GFW is effective at complementally treating PCOS through various mechanisms,including inhibiting inflammatory responses,modulating the intraovarian extracellular matrix,regulating apoptosis and autophagy in granulosa cells,and correcting oxidative stress imbalances.In addition,the GFW has been shown to be effective in treating the complications of PCOS.However,there are several problems,and future work should focus on elucidating the efficacy,safe dosage,and safety of different dosage forms of GFW,increasing the toxicological value of traditional Chinese medicine,and confirming the safety of the combination of GFW with Western medicine for the treatment of PCOS.展开更多
Objective:To investigate the efficacy of Dabuyin Wan(Concentrated Pills)in the treatment of prepubertal gynecomastia in boys and to analyze its impact on sex hormone levels.Methods:A total of 100 boys with gynecomasti...Objective:To investigate the efficacy of Dabuyin Wan(Concentrated Pills)in the treatment of prepubertal gynecomastia in boys and to analyze its impact on sex hormone levels.Methods:A total of 100 boys with gynecomastia diagnosed and treated in our hospital from July 2022 to February 2025 were selected and randomly divided into two groups using a random number table,with 50 cases in each group.The control group received non-pharmacological treatment,while the observation group was treated with Dabuyin Wan(Concentrated Pills).Both groups continued treatment for 6 months.Clinical efficacy,TCM syndrome scores,sex hormone levels[estradiol(E2),luteinizing hormone(LH),testosterone(T),prolactin(PRL)],and adverse reactions were compared between the two groups.Results:The total clinical effective rate in the observation group was higher than that in the control group(χ²=5.316,P<0.05).After treatment,the TCM syndrome score in the observation group was lower than that in the control group(t=15.513,P<0.05).After treatment,E2,LH,and PRL levels in the observation group were lower than those in the control group,while the T level in the observation group was higher than that in the control group(t=5.819,11.000,7.275,9.524,respectively;P<0.05 for all).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:The use of Dabuyin Wan(Concentrated Pills)for prepubertal gynecomastia in boys can improve clinical outcomes,alleviate clinical symptoms,modulate sex hormone levels,and demonstrate a favorable safety profile.展开更多
近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用...近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用为背景,探讨了NFV在其中的作用和优化策略。首先,建立了一个SD-WAN环境,采用网络功能虚拟化技术,实现了如防火墙,负载均衡等核心网络功能的动态配置和部署。实验结果表明,相对于传统的物理设备,NFV技术在不影响网络性能的同时,降低了设备成本和维护成本。然后,针对SD-WAN的特点,提出了一种资源调度优化算法,其能根据实时网络状况,动态调整虚拟网络功能的资源分配,从而进一步提高其性能。通过实验证明,该优化策略可有效提升整体网络的灵活性、稳定性和效能,这为SD-WAN的实际应用场景提供了有效的优化策略参考,有助于推动NFV在SD-WAN等宽域网络中的进一步应用。展开更多
随着高清视频和实时流媒体业务的快速增长,智能数据中心面临传输稳定性与服务质量(Quality of Service,QoS)保障的双重挑战。基于此,研究软件定义广域网络(Software Defined Wide Area Network,SD-WAN)在视频流传输中的路径调度优化、Qo...随着高清视频和实时流媒体业务的快速增长,智能数据中心面临传输稳定性与服务质量(Quality of Service,QoS)保障的双重挑战。基于此,研究软件定义广域网络(Software Defined Wide Area Network,SD-WAN)在视频流传输中的路径调度优化、QoS保障机制与安全策略设计,分析其在高清视频分发、视频会议保障、边缘协同处理与远程监控管理中的应用效果,探讨SD-WAN在构建高效、安全、智能的视频网络传输体系中的技术路径。展开更多
软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于...软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于混合链路多Overlay隧道实现网络规模解耦下快速路由切换的新型设计,在广域网链路中断后提供路由收敛时间确定性上界保证,给出关键的数据结构及工作流程,对相关工程实施具备较好的指导作用。展开更多
SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影...SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。展开更多
基金supported by funds from the Natural Science Foundation of Shandong Province(No.ZR2020MH346No.ZR2021MH003)the National Natural Science Foundation of China(No.81273667).
文摘Polycystic ovary syndrome(PCOS)is a prevalent endocrine disorder that poses a significant threat to women’s health.As a classical traditional Chinese medicine(TCM)formulation,Guizhi-Fuling Wan(GFW)has a good application prospect in the complementary treatment of PCOS.This study aimed to systematically summarize the traditional efficacy and pharmacological composition of the Chinese medicines contained in GFW and evaluate the clinical efficacy and safety of their active ingredients in the complementary treatment of PCOS.A growing number of studies have demonstrated that GFW is effective at complementally treating PCOS through various mechanisms,including inhibiting inflammatory responses,modulating the intraovarian extracellular matrix,regulating apoptosis and autophagy in granulosa cells,and correcting oxidative stress imbalances.In addition,the GFW has been shown to be effective in treating the complications of PCOS.However,there are several problems,and future work should focus on elucidating the efficacy,safe dosage,and safety of different dosage forms of GFW,increasing the toxicological value of traditional Chinese medicine,and confirming the safety of the combination of GFW with Western medicine for the treatment of PCOS.
基金The Seventh Phase of Hangzhou Science and Technology Special Project for the Development and Support of the Biomedicine and Health Industry(Project No.:2022WJC134)。
文摘Objective:To investigate the efficacy of Dabuyin Wan(Concentrated Pills)in the treatment of prepubertal gynecomastia in boys and to analyze its impact on sex hormone levels.Methods:A total of 100 boys with gynecomastia diagnosed and treated in our hospital from July 2022 to February 2025 were selected and randomly divided into two groups using a random number table,with 50 cases in each group.The control group received non-pharmacological treatment,while the observation group was treated with Dabuyin Wan(Concentrated Pills).Both groups continued treatment for 6 months.Clinical efficacy,TCM syndrome scores,sex hormone levels[estradiol(E2),luteinizing hormone(LH),testosterone(T),prolactin(PRL)],and adverse reactions were compared between the two groups.Results:The total clinical effective rate in the observation group was higher than that in the control group(χ²=5.316,P<0.05).After treatment,the TCM syndrome score in the observation group was lower than that in the control group(t=15.513,P<0.05).After treatment,E2,LH,and PRL levels in the observation group were lower than those in the control group,while the T level in the observation group was higher than that in the control group(t=5.819,11.000,7.275,9.524,respectively;P<0.05 for all).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:The use of Dabuyin Wan(Concentrated Pills)for prepubertal gynecomastia in boys can improve clinical outcomes,alleviate clinical symptoms,modulate sex hormone levels,and demonstrate a favorable safety profile.
文摘近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用为背景,探讨了NFV在其中的作用和优化策略。首先,建立了一个SD-WAN环境,采用网络功能虚拟化技术,实现了如防火墙,负载均衡等核心网络功能的动态配置和部署。实验结果表明,相对于传统的物理设备,NFV技术在不影响网络性能的同时,降低了设备成本和维护成本。然后,针对SD-WAN的特点,提出了一种资源调度优化算法,其能根据实时网络状况,动态调整虚拟网络功能的资源分配,从而进一步提高其性能。通过实验证明,该优化策略可有效提升整体网络的灵活性、稳定性和效能,这为SD-WAN的实际应用场景提供了有效的优化策略参考,有助于推动NFV在SD-WAN等宽域网络中的进一步应用。
文摘随着高清视频和实时流媒体业务的快速增长,智能数据中心面临传输稳定性与服务质量(Quality of Service,QoS)保障的双重挑战。基于此,研究软件定义广域网络(Software Defined Wide Area Network,SD-WAN)在视频流传输中的路径调度优化、QoS保障机制与安全策略设计,分析其在高清视频分发、视频会议保障、边缘协同处理与远程监控管理中的应用效果,探讨SD-WAN在构建高效、安全、智能的视频网络传输体系中的技术路径。
文摘软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于混合链路多Overlay隧道实现网络规模解耦下快速路由切换的新型设计,在广域网链路中断后提供路由收敛时间确定性上界保证,给出关键的数据结构及工作流程,对相关工程实施具备较好的指导作用。
文摘SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。
