As new-generation intelligent technologies rapidly evolve,enhancing artificial intelligence(AI)education has become a global consensus,and improving AI literacy is a key focus in higher education.To address the lack o...As new-generation intelligent technologies rapidly evolve,enhancing artificial intelligence(AI)education has become a global consensus,and improving AI literacy is a key focus in higher education.To address the lack of relevant knowledge among non-computer science students,the complexity of the material,which leads to low interest and high difficulty in learning,this paper proposes a three-pronged teaching design model:“BOPPPS model+large language models(LLMs)+mind maps with 3w2h”.This model aims to assist teachers in designing practical teaching cases and engaging,interactive activities,and provides examples of its application to help teachers better teach AI and improve the AI literacy of non-computer science students.展开更多
目的探讨细胞色素P450酶2W1(cytochrome P450 family 2 subfamily W member 1,CYP2W1)、微小RNA-491-5p(microRNA-491-5p,miR-491-5p)在肝细胞癌(hepatocellular cancer,HCC)组织中的表达与临床病理特征的关系和预后的相关性分析。方法...目的探讨细胞色素P450酶2W1(cytochrome P450 family 2 subfamily W member 1,CYP2W1)、微小RNA-491-5p(microRNA-491-5p,miR-491-5p)在肝细胞癌(hepatocellular cancer,HCC)组织中的表达与临床病理特征的关系和预后的相关性分析。方法选取2019年2月~2021年2月在我院进行手术治疗的120例HCC作为研究对象,手术过程中取HCC组织和癌旁组织标本。实时荧光定量PCR(qRT-PCR)法检测mRNA表达水平,免疫组化法检测蛋白表达水平。分析HCC组织和癌旁组织中miR-491-5p与CYP2W1 mRNA表达的差异及二者表达与患者临床病理特征的相关性,并做Kaplan-Meier生存分析曲线。结果HCC组织中CYP2W1 mRNA表达水平显著高于癌旁组织,miR-491-5p表达水平显著低于癌旁组织(P<0.05);HCC组织中CYP2W1蛋白阳性表达率显著高于癌旁组织(χ^(2)=23.721,P<0.001)。HCC组织中miR-491-5p与CYP2W1 mRNA表达水平呈负相关(r=-0.417,P<0.001)。CYP2W1、miR-491-5p表达与HCC患者TNM分期、肿瘤分化程度、淋巴结转移和病理分级存在显著相关性(P<0.05)。Kaplan-Meier生存分析曲线显示,CYP2W1阳性表达组3年累积生存率为31.4%,低于CYP2W1阴性表达组的63.8%(log-rankχ^(2)=12.243,P=0.000);miR-491-5p高表达组3年累积生存率为61.3%,显著高于miR-491-5p低表达组的37.9%(log-rankχ^(2)=4.490,P=0.034)。复发组HCC组织中CYP2W1 mRNA表达水平显著高于未复发组,miR-491-5p表达水平显著低于未复发组(P<0.05);转移组HCC组织中CYP2W1 mRNA表达水平显著高于未转移组,miR-491-5p表达水平显著低于未转移组(P<0.05)。结论HCC组织中CYP2W1高表达,miR-491-5p低表达,二者与HCC患者的部分临床病理特征和预后存在显著相关性。展开更多
The morphology and dimension of W phases play an important role in determining mechanical properties of Mg-RE-Zn(where RE denotes rare earth elements)alloys.In this study,theγ′platelet and W particle occurred in the...The morphology and dimension of W phases play an important role in determining mechanical properties of Mg-RE-Zn(where RE denotes rare earth elements)alloys.In this study,theγ′platelet and W particle occurred in the aged Mg-2Dy-0.5Zn(at.%)alloys were investigated by aberration-corrected scanning transmission electron microscopy.A novel formation mechanism of W phase was proposed,and its effects on the morphology and dimension of W particle,as well as mechanical properties of Mg-2Dy-0.5Zn alloys,were also discussed particularly.Different from other Mg-RE-Zn alloys,the nucleation and growth of W particle in Mg-Dy-Zn alloys mainly depend on the precipitatedγ′platelet.Primarily,a mass of Dy and Zn solute atoms concentrated nearγ′platelet or between two adjacentγ′platelets can meet the composition requirement of W particle nucleation.Next,the smaller interfacial mismatch between W andγ′facilitates the nucleation and growth of W particle.Thirdly,the growth of W particle can be achieved by consuming the surroundingγ′platelets.The nucleation and growth mechanisms make W particles exhibit rectangular or leaf-like and remain at the nanoscale.The coexistence ofγ′platelets and nanoscale W particles,and some better interfacial relationships between phases,lead to a high strength-ductility synergy of alloy.The findings may provide some fundamental guidelines for the microstructure design and optimization of new-type Mg-based alloys.展开更多
文摘As new-generation intelligent technologies rapidly evolve,enhancing artificial intelligence(AI)education has become a global consensus,and improving AI literacy is a key focus in higher education.To address the lack of relevant knowledge among non-computer science students,the complexity of the material,which leads to low interest and high difficulty in learning,this paper proposes a three-pronged teaching design model:“BOPPPS model+large language models(LLMs)+mind maps with 3w2h”.This model aims to assist teachers in designing practical teaching cases and engaging,interactive activities,and provides examples of its application to help teachers better teach AI and improve the AI literacy of non-computer science students.
文摘目的探讨细胞色素P450酶2W1(cytochrome P450 family 2 subfamily W member 1,CYP2W1)、微小RNA-491-5p(microRNA-491-5p,miR-491-5p)在肝细胞癌(hepatocellular cancer,HCC)组织中的表达与临床病理特征的关系和预后的相关性分析。方法选取2019年2月~2021年2月在我院进行手术治疗的120例HCC作为研究对象,手术过程中取HCC组织和癌旁组织标本。实时荧光定量PCR(qRT-PCR)法检测mRNA表达水平,免疫组化法检测蛋白表达水平。分析HCC组织和癌旁组织中miR-491-5p与CYP2W1 mRNA表达的差异及二者表达与患者临床病理特征的相关性,并做Kaplan-Meier生存分析曲线。结果HCC组织中CYP2W1 mRNA表达水平显著高于癌旁组织,miR-491-5p表达水平显著低于癌旁组织(P<0.05);HCC组织中CYP2W1蛋白阳性表达率显著高于癌旁组织(χ^(2)=23.721,P<0.001)。HCC组织中miR-491-5p与CYP2W1 mRNA表达水平呈负相关(r=-0.417,P<0.001)。CYP2W1、miR-491-5p表达与HCC患者TNM分期、肿瘤分化程度、淋巴结转移和病理分级存在显著相关性(P<0.05)。Kaplan-Meier生存分析曲线显示,CYP2W1阳性表达组3年累积生存率为31.4%,低于CYP2W1阴性表达组的63.8%(log-rankχ^(2)=12.243,P=0.000);miR-491-5p高表达组3年累积生存率为61.3%,显著高于miR-491-5p低表达组的37.9%(log-rankχ^(2)=4.490,P=0.034)。复发组HCC组织中CYP2W1 mRNA表达水平显著高于未复发组,miR-491-5p表达水平显著低于未复发组(P<0.05);转移组HCC组织中CYP2W1 mRNA表达水平显著高于未转移组,miR-491-5p表达水平显著低于未转移组(P<0.05)。结论HCC组织中CYP2W1高表达,miR-491-5p低表达,二者与HCC患者的部分临床病理特征和预后存在显著相关性。
基金supported by Natural Science Foundation of Liaoning Province of China under Grant No.2020-MS-085。
文摘The morphology and dimension of W phases play an important role in determining mechanical properties of Mg-RE-Zn(where RE denotes rare earth elements)alloys.In this study,theγ′platelet and W particle occurred in the aged Mg-2Dy-0.5Zn(at.%)alloys were investigated by aberration-corrected scanning transmission electron microscopy.A novel formation mechanism of W phase was proposed,and its effects on the morphology and dimension of W particle,as well as mechanical properties of Mg-2Dy-0.5Zn alloys,were also discussed particularly.Different from other Mg-RE-Zn alloys,the nucleation and growth of W particle in Mg-Dy-Zn alloys mainly depend on the precipitatedγ′platelet.Primarily,a mass of Dy and Zn solute atoms concentrated nearγ′platelet or between two adjacentγ′platelets can meet the composition requirement of W particle nucleation.Next,the smaller interfacial mismatch between W andγ′facilitates the nucleation and growth of W particle.Thirdly,the growth of W particle can be achieved by consuming the surroundingγ′platelets.The nucleation and growth mechanisms make W particles exhibit rectangular or leaf-like and remain at the nanoscale.The coexistence ofγ′platelets and nanoscale W particles,and some better interfacial relationships between phases,lead to a high strength-ductility synergy of alloy.The findings may provide some fundamental guidelines for the microstructure design and optimization of new-type Mg-based alloys.
