The contribution of functional virtual prototyping to vehicle chassis development is presented. The different topics that we took into consideration were reform analysis and improvement design during the vehicle chass...The contribution of functional virtual prototyping to vehicle chassis development is presented. The different topics that we took into consideration were reform analysis and improvement design during the vehicle chassis development. A frame of coordinates based on the digital-model was established, the main CAE analy- sis methods, multi-body system dynamics and finite element analysis were applied to the digital-model build by CAD/CAM software. The method was applied in the vehicle chassis reform analysis and improvement design, all the analysis and design projects were implemented in the uniform digital-model, and the development was carried through effectively.展开更多
Molecular dynamics simulation has been performed to simulate the interaction between PESA and the （001） face of anhydrite crystal CaSO4 at different temperatures with the presence of various number of H2O molecules....Molecular dynamics simulation has been performed to simulate the interaction between PESA and the （001） face of anhydrite crystal CaSO4 at different temperatures with the presence of various number of H2O molecules. The results show that PESA can effectively prevent the growth of CaSO4 scale at 323-343 K. At the same temperature, the binding energy between PESA and the （001） face of CaSO4 for systems with various number of H2O has the order of E-bind（OH2O）〉Ebind（200-400H2O）〉E, bind（lOOH2O）. For the same system at different temperatures the binding energies are close and are mainly contributed from the Coulomb interaction, including ionic bonds. The bonds are formed between the calcium atoms of anhydrite scale crystal and the Hydrogen bonds are formed between the O oxygen atoms of the carboxyl group of PESA. atoms of the carboxyl group of PESA and the H atoms of H2O. van der Waals interaction is conducive to the stability of the system of PESA, H2O, and CaSO4. The radial distribution functions of O（carbonyl of PESA）-H（H2O）, O（CaSO4）-H（H2O）, and O（CaSO4）-H（PESA） imply that solvents have effects on the anti-scale performance of PESA to CaSO4.展开更多
The positioning combined with multi-functioning and interactive mechanics in dynamic testing of slender bridges are treated in present paper. The approach takes into account multiple functions in dynamic testing of sl...The positioning combined with multi-functioning and interactive mechanics in dynamic testing of slender bridges are treated in present paper. The approach takes into account multiple functions in dynamic testing of slender bridges constructed of thin-walled structural members with their hierarchical configuration. Theoretical, numerical and experimental in situ assessments of the problem are presented. Some results of the application in situ are submitted.展开更多
The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)gained tremendous attention due to its high infectivity and pathogenicity.The 3-chymotrypsin-like hydrolase protease(Mpro)of SARS-CoV-2 has been proven to...The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)gained tremendous attention due to its high infectivity and pathogenicity.The 3-chymotrypsin-like hydrolase protease(Mpro)of SARS-CoV-2 has been proven to be an important target for anti-SARS-CoV-2 activity.To better identify the drugs with potential in treating coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 and according to the crystal structure of Mpro,we conducted a virtual screening of FDA-approved drugs and chemical agents that have entered clinical trials.As a result,9 drug candidates with therapeutic potential for the treatment of COVID-19 and with good docking scores were identified to target SARS-CoV-2.Consequently,molecular dynamics(MD)simulation was performed to explore the dynamic interactions between the predicted drugs and Mpro.The binding mode during MD simulation showed that hydrogen bonding and hydrophobic interactions played an important role in the binding processes.Based on the binding free energy calculated by using MM/PBSA,Lopiravir,an inhibitor of human immunodeficiency virus(HIV)protease,is under investigation for the treatment of COVID-19 in combination with ritionavir,and it might inhibit Mpro effectively.Moreover,Ombitasvir,an inhibitor for non-structural protein 5 A of hepatitis C virus(HCV),has good inhibitory potency for Mpro.It is notable that the GS-6620 has a binding free energy,with respect to binding Mpro,comparable to that of ombitasvir.Our study suggests that ombitasvir and lopinavir are good drug candidates for the treatment of COVID-19,and that GS-6620 has good anti-SARS-CoV-2 activity.展开更多
近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用...近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用为背景,探讨了NFV在其中的作用和优化策略。首先,建立了一个SD-WAN环境,采用网络功能虚拟化技术,实现了如防火墙,负载均衡等核心网络功能的动态配置和部署。实验结果表明,相对于传统的物理设备,NFV技术在不影响网络性能的同时,降低了设备成本和维护成本。然后,针对SD-WAN的特点,提出了一种资源调度优化算法,其能根据实时网络状况,动态调整虚拟网络功能的资源分配,从而进一步提高其性能。通过实验证明,该优化策略可有效提升整体网络的灵活性、稳定性和效能,这为SD-WAN的实际应用场景提供了有效的优化策略参考,有助于推动NFV在SD-WAN等宽域网络中的进一步应用。展开更多
文摘The contribution of functional virtual prototyping to vehicle chassis development is presented. The different topics that we took into consideration were reform analysis and improvement design during the vehicle chassis development. A frame of coordinates based on the digital-model was established, the main CAE analy- sis methods, multi-body system dynamics and finite element analysis were applied to the digital-model build by CAD/CAM software. The method was applied in the vehicle chassis reform analysis and improvement design, all the analysis and design projects were implemented in the uniform digital-model, and the development was carried through effectively.
文摘Molecular dynamics simulation has been performed to simulate the interaction between PESA and the （001） face of anhydrite crystal CaSO4 at different temperatures with the presence of various number of H2O molecules. The results show that PESA can effectively prevent the growth of CaSO4 scale at 323-343 K. At the same temperature, the binding energy between PESA and the （001） face of CaSO4 for systems with various number of H2O has the order of E-bind（OH2O）〉Ebind（200-400H2O）〉E, bind（lOOH2O）. For the same system at different temperatures the binding energies are close and are mainly contributed from the Coulomb interaction, including ionic bonds. The bonds are formed between the calcium atoms of anhydrite scale crystal and the Hydrogen bonds are formed between the O oxygen atoms of the carboxyl group of PESA. atoms of the carboxyl group of PESA and the H atoms of H2O. van der Waals interaction is conducive to the stability of the system of PESA, H2O, and CaSO4. The radial distribution functions of O（carbonyl of PESA）-H（H2O）, O（CaSO4）-H（H2O）, and O（CaSO4）-H（PESA） imply that solvents have effects on the anti-scale performance of PESA to CaSO4.
文摘The positioning combined with multi-functioning and interactive mechanics in dynamic testing of slender bridges are treated in present paper. The approach takes into account multiple functions in dynamic testing of slender bridges constructed of thin-walled structural members with their hierarchical configuration. Theoretical, numerical and experimental in situ assessments of the problem are presented. Some results of the application in situ are submitted.
基金supported by the National Natural Science Foundation of China(31400667)Chongqing Municipal Education Commission Science and Technology Research Project(KJZD-K201801102)+2 种基金Chongqing Research Program of Basic Research and Frontier Technology(cstc2018jcyj AX0683)Opening Foundation of State Key Laboratory of Silkworm Genome Biology(sklsgb1819-2)Computational support from the Information Center of Chongqing University of Technology。
文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)gained tremendous attention due to its high infectivity and pathogenicity.The 3-chymotrypsin-like hydrolase protease(Mpro)of SARS-CoV-2 has been proven to be an important target for anti-SARS-CoV-2 activity.To better identify the drugs with potential in treating coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 and according to the crystal structure of Mpro,we conducted a virtual screening of FDA-approved drugs and chemical agents that have entered clinical trials.As a result,9 drug candidates with therapeutic potential for the treatment of COVID-19 and with good docking scores were identified to target SARS-CoV-2.Consequently,molecular dynamics(MD)simulation was performed to explore the dynamic interactions between the predicted drugs and Mpro.The binding mode during MD simulation showed that hydrogen bonding and hydrophobic interactions played an important role in the binding processes.Based on the binding free energy calculated by using MM/PBSA,Lopiravir,an inhibitor of human immunodeficiency virus(HIV)protease,is under investigation for the treatment of COVID-19 in combination with ritionavir,and it might inhibit Mpro effectively.Moreover,Ombitasvir,an inhibitor for non-structural protein 5 A of hepatitis C virus(HCV),has good inhibitory potency for Mpro.It is notable that the GS-6620 has a binding free energy,with respect to binding Mpro,comparable to that of ombitasvir.Our study suggests that ombitasvir and lopinavir are good drug candidates for the treatment of COVID-19,and that GS-6620 has good anti-SARS-CoV-2 activity.
文摘近年来,网络功能虚拟化(NFV)以其网络设备功能解耦和无缝交互等优势,逐步成为现代网络设计的核心技术。其中,SD-WAN(Software Defined Wide Area Network)以其可编程性和灵活性,为NFV应用的场景提供了广阔的空间。文中以SD-WAN实际应用为背景,探讨了NFV在其中的作用和优化策略。首先,建立了一个SD-WAN环境,采用网络功能虚拟化技术,实现了如防火墙,负载均衡等核心网络功能的动态配置和部署。实验结果表明,相对于传统的物理设备,NFV技术在不影响网络性能的同时,降低了设备成本和维护成本。然后,针对SD-WAN的特点,提出了一种资源调度优化算法,其能根据实时网络状况,动态调整虚拟网络功能的资源分配,从而进一步提高其性能。通过实验证明,该优化策略可有效提升整体网络的灵活性、稳定性和效能,这为SD-WAN的实际应用场景提供了有效的优化策略参考,有助于推动NFV在SD-WAN等宽域网络中的进一步应用。
