Due to the study of the function of heart and aoritic valve, we set up a physicalmodel of left ventricle, aortic valve and afterload and derive theoretical equation of each part from the model. Then we calculate the h...Due to the study of the function of heart and aoritic valve, we set up a physicalmodel of left ventricle, aortic valve and afterload and derive theoretical equation of each part from the model. Then we calculate the hasic equations within phystology and impair parameters. Bwsed on this, we will discus fully in the next paper the effectofleyt ventricular afterloadon valve opining, ejection and valve Jumction .etc展开更多
Background The surgical outcomes have been greatly improved over the past four decades for functional single ventricle(FSV). However,the repair for coexistence of FSV and total anomalous pulmonary venous connection(TA...Background The surgical outcomes have been greatly improved over the past four decades for functional single ventricle(FSV). However,the repair for coexistence of FSV and total anomalous pulmonary venous connection(TAPVC),especially obstructed TAPVC,has remained a clinical challenge. Little is known about the results of surgical treatment for patients with FSV-TAPVC in China. Methods Forty consecutive patients with FSV-TAPVC undergoing initial surgical palliation(median age:16.8 months;body weight:8.25 kg)were retrospectively enrolled from 2006 to 2016 in a specialized cardiovascular institute. TAPVC was repaired in 30 patients. The mean follow-up period was 49 months. Results All of the 7 patients with preoperative pulmonary vein obstruction(PVO)underwent repair of TAPVC at the first operation and survived. When a systemic to pulmonary(S-P)shunt or pulmonary artery banding(PAB)was necessary,patients with concomitant TAPVC repair had lower mortality(30.0%)and higher total cavopulmonary connection completion rate(20.0%)than those without TAPVC repair[75.0% and 0%,respectively],although with no statistical significance(Fisher test,P=0.505 and P=0.245). The overall survival rates for the cohort at 1,3 and 5 years after the initial surgical intervention were 80.0%,77.1% and 77.1%,respectively. Multivariate COX regression analysis detected that SP shunt(adjusted odds ratio:6.51;95%CI:1.26-33.71,P=0.030)is the only risk factor for survival. The reintervention rate for postoperative PVO was higher in patients with preoperative PVO than those without(57.1%vs. 4.3%,Log Rank:P=0.006). Conclusion The mid-term results of surgical repair of FSV-TAPVC are still challenging. When PVO exists,surgical repair for TAPVC is suggested as soon as possible. Repair for TAPVC should also be considered when S-P shunt or PAB is necessary. Further study with larger population are warranted to support our finding.展开更多
<strong>Background:</strong><span style="font-family:Verdana;"> Heart failure is the commonest cardiovascular complication in type 2 diabetes mellitus. However, subclinical left ventricular...<strong>Background:</strong><span style="font-family:Verdana;"> Heart failure is the commonest cardiovascular complication in type 2 diabetes mellitus. However, subclinical left ventricular dysfunction can’t be detected using 2D echocardiography which </span><span style="font-family:Verdana;">is </span><span style="font-family:;" "=""><span style="font-family:Verdana;">routinely used for cardiac evaluation of diabetic patients. We aimed to determine the prevalence and factors associated to left ventricular global longitudinal strain (LV GLS) impairment in type 2 diabetes Cameroonians patients. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We conducted a cross-sectional study from January 2019 to June 2019, including type 2 diabetes patients with preserved left ventricle ejection fraction. Clinical and echocardiographic data were collected, and LV GLS was assessed using speckle tracking technique, a value ≤</span></span><span style="font-family:Verdana;"> -</span><span style="font-family:;" "=""><span style="font-family:Verdana;">16% been considered as normal value. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We recruited 95 patients, with a mean age of 57.4 ± 11.8 years old and median diabetes duration of 5 [2 </span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 12] years. Echocardiographic evaluation found 56.3% of left ventricle remodelling, 51.6% of left ventricle diastolic dysfunction and mean left ventricle ejection of 63.3</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;"> ± 6.6%. LV GLS impairment was present in 43.2% (95% CI: 32.6 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 53.7) of the participants. After adjustment to all significantly associated factors, Obesity (aOR: 4;95% CI: 1.5 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 10.6) and diastolic dysfunction (aOR: 3.1;95% CI: 1.2 </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> 8.2) were independent factors associated with LV GLS. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Subclinical systolic dysfunction assessed by LV GLS impairment is frequent in diabetic patients. Further research should be carried out more extensively to integrate LV GLS in the type 2 diabetes patients’ routine follow up for a better prognostic outcome, especially in low-incomes countries.</span></span>展开更多
文摘Due to the study of the function of heart and aoritic valve, we set up a physicalmodel of left ventricle, aortic valve and afterload and derive theoretical equation of each part from the model. Then we calculate the hasic equations within phystology and impair parameters. Bwsed on this, we will discus fully in the next paper the effectofleyt ventricular afterloadon valve opining, ejection and valve Jumction .etc
基金the National Key R&D Program of China(No.2018YFC1002600)National Natural Science Foundation of China(No.81903287)+4 种基金Natural Science Foundation of Guangdong Province(No.2018A030313329)the Science and Technology Planning Project of Guangdong Province(No.2017A070701013)the Science and Technological Program of Guangzhou,China(No.201704020126)Guangdong Medical Research Foundation(No.A2017328)Guangdong Provincial Administration of Traditional Chinese Medicine(No.20181004).
文摘Background The surgical outcomes have been greatly improved over the past four decades for functional single ventricle(FSV). However,the repair for coexistence of FSV and total anomalous pulmonary venous connection(TAPVC),especially obstructed TAPVC,has remained a clinical challenge. Little is known about the results of surgical treatment for patients with FSV-TAPVC in China. Methods Forty consecutive patients with FSV-TAPVC undergoing initial surgical palliation(median age:16.8 months;body weight:8.25 kg)were retrospectively enrolled from 2006 to 2016 in a specialized cardiovascular institute. TAPVC was repaired in 30 patients. The mean follow-up period was 49 months. Results All of the 7 patients with preoperative pulmonary vein obstruction(PVO)underwent repair of TAPVC at the first operation and survived. When a systemic to pulmonary(S-P)shunt or pulmonary artery banding(PAB)was necessary,patients with concomitant TAPVC repair had lower mortality(30.0%)and higher total cavopulmonary connection completion rate(20.0%)than those without TAPVC repair[75.0% and 0%,respectively],although with no statistical significance(Fisher test,P=0.505 and P=0.245). The overall survival rates for the cohort at 1,3 and 5 years after the initial surgical intervention were 80.0%,77.1% and 77.1%,respectively. Multivariate COX regression analysis detected that SP shunt(adjusted odds ratio:6.51;95%CI:1.26-33.71,P=0.030)is the only risk factor for survival. The reintervention rate for postoperative PVO was higher in patients with preoperative PVO than those without(57.1%vs. 4.3%,Log Rank:P=0.006). Conclusion The mid-term results of surgical repair of FSV-TAPVC are still challenging. When PVO exists,surgical repair for TAPVC is suggested as soon as possible. Repair for TAPVC should also be considered when S-P shunt or PAB is necessary. Further study with larger population are warranted to support our finding.
文摘<strong>Background:</strong><span style="font-family:Verdana;"> Heart failure is the commonest cardiovascular complication in type 2 diabetes mellitus. However, subclinical left ventricular dysfunction can’t be detected using 2D echocardiography which </span><span style="font-family:Verdana;">is </span><span style="font-family:;" "=""><span style="font-family:Verdana;">routinely used for cardiac evaluation of diabetic patients. We aimed to determine the prevalence and factors associated to left ventricular global longitudinal strain (LV GLS) impairment in type 2 diabetes Cameroonians patients. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We conducted a cross-sectional study from January 2019 to June 2019, including type 2 diabetes patients with preserved left ventricle ejection fraction. Clinical and echocardiographic data were collected, and LV GLS was assessed using speckle tracking technique, a value ≤</span></span><span style="font-family:Verdana;"> -</span><span style="font-family:;" "=""><span style="font-family:Verdana;">16% been considered as normal value. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> We recruited 95 patients, with a mean age of 57.4 ± 11.8 years old and median diabetes duration of 5 [2 </span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 12] years. Echocardiographic evaluation found 56.3% of left ventricle remodelling, 51.6% of left ventricle diastolic dysfunction and mean left ventricle ejection of 63.3</span><span style="font-family:Verdana;">%</span><span style="font-family:Verdana;"> ± 6.6%. LV GLS impairment was present in 43.2% (95% CI: 32.6 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 53.7) of the participants. After adjustment to all significantly associated factors, Obesity (aOR: 4;95% CI: 1.5 </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 10.6) and diastolic dysfunction (aOR: 3.1;95% CI: 1.2 </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> 8.2) were independent factors associated with LV GLS. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> Subclinical systolic dysfunction assessed by LV GLS impairment is frequent in diabetic patients. Further research should be carried out more extensively to integrate LV GLS in the type 2 diabetes patients’ routine follow up for a better prognostic outcome, especially in low-incomes countries.</span></span>
