Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and poten...Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.展开更多
Objective: To evaluate the efficacy and tolerance of a local treatment combining two antibacterials and one antifungal in patients with a clinical presentation suggesting infectious vaginitis. Patients and methods: 16...Objective: To evaluate the efficacy and tolerance of a local treatment combining two antibacterials and one antifungal in patients with a clinical presentation suggesting infectious vaginitis. Patients and methods: 169 patients presenting with clinical criteria for vaginitis were included in an open, multicenter trial. Vaginal samples were taken for microbiological analyses and a triple-combination product of nystatin, neomycin and polymyxin B was then started as local treatment, without waiting for the test results. The treatment was continued with the usual dosage (1 vaginal capsule at bedtime for 12 days) for vaginal infections in the scope of the combination product with approved labeling. A second vaginal sample was performed at the end of the treatment. The main efficacy criterion was the clinical success rate (cure or improvement of the clinical signs and symptoms) according to the investigator.Results: 93 patients were included in the efficacy population. Non-exclusively fungal vaginitis (strictly bacterial or bacterial + fungal) represented 31.2% of the cases. The clinical success rate was 97.8% according to the investigator and 95.7% according to the patients. The microbiological success rate was 81.3%, with no differences between etiologies (Candida spp., bacteria or both). The combination product was well-tolerated, despite the local inflammation before treatment. Discussion and conclusion: Given the etiological diversity of vaginitis, this trial supports the efficacy of a triple-combination product (nystatin, neomycin, polymyxin B) as a first-line local treatment of Candida, bacterial or mixed vaginitis.展开更多
Objective To investigate IUD-related vaginitis in IUD users at the University College Hospital Ibadan, South-western Nigeria.Methods A prospective cohort study in IUD users present with abnormal vaginal discharge at t...Objective To investigate IUD-related vaginitis in IUD users at the University College Hospital Ibadan, South-western Nigeria.Methods A prospective cohort study in IUD users present with abnormal vaginal discharge at the family planning clinic of the University College Hospital, Ibadan was conducted between lOth of October, 2008 and 31st of May 2009. High Vaginal Swabs were taken from the clients for microbiology, culture and drug sensitivity test. Diagnosis of bacterial vaginosis was made based on gram stained vaginal smear using the standard Nugents criteria. Other aetiological agents were identified either on wet preparation or culture using standard techniques. Treatment given was by the family planning nurse, as was the protocol at the family planning clinic.Results Twenty-four IUD users present at the Jamtty ptannmg ctmtc with vaginal discharge were studied. Their ages ranged 28-51 years（38.14 ± 5.9 years）, Mean parity was 4.4 ± 1.4, All the women were married and all used CuT 380A. The mean duration of lUCD use was 2.5 years only. Majority （46%） had used it for more than 3 years and most （75%） of the visits were unscheduled. All the clients complained of abnormal vaginal discharge which was copious, watery and foul smelling, or clumpy. Nine users （37.5%） complained of pruritus vulvae, 3 users （12.5%） lower abdominal pain, 1 user （4,2%） dyspareunia and vaginosis was made in 16 （66. 7%） and 1 （4.2%） dysuria. The diagnosis of bacterial vaginal candidiasis in 8 （33.3%）. Age less than 40 years, Christianity and IUD use more than 3 years were associated with a higher risk of bacterial vaginosis （OR=1.29, 1.67 and 6.6, respectively）, while women above 40 years, Muslims and women with lower educational status had a higher risk of candida-related vaginitis （OR=1.67 and 4.2, respectively）. Eight clients （33.3%） were treated for candidiasis with antifungals （3 empirically, and 5 after obtaining results of vaginal swab）, 9 （37.5%） were given oral metronidazole, 3 patients were referred to the gynaecological emergency unit on account of abdominal pain and 4 did not return for follow up.Conclusion IUD associated vaginitis is a disturbing condition causing unscheduled visits among IUD users. Bacterial vaginosis and Candidia albicans are major aetiologies in south western Nigeria Ibadan. Persistent discharge is a documented reason for discontinuation of lUD use. Periodic empirical treatment for candidiasis and bacterial vaginosis with antifungals and oral metronidazole is advocated. This may reduce the discomfort caused by IUD-related vaginitis, the risk of PID and other risks exposed to the IUD users and ensure continued use of the IUD.展开更多
Objectives: The balance of the vaginal ecosystem depends on lactobacilli whose biofilm protectsagainst microorganisms that are not normally present or are subdominant in vaginal flora. Vaginal?infection treatments sho...Objectives: The balance of the vaginal ecosystem depends on lactobacilli whose biofilm protectsagainst microorganisms that are not normally present or are subdominant in vaginal flora. Vaginal?infection treatments should eliminate pathogens while preserving the?Lactobacillus?flora to prevent relapse or recurrence. The objective of this study was to determine the sensitivity of lactobacilli to antiseptics, antibiotics and antifungal agents used, alone or in combination, in the topical treatment of infectious vaginitis. Materials and Methods: The minimum inhibitory concentration (MIC) of 15 active ingredients and the minimum inhibitory dilution (MID) of 17 pharmaceuticals products were determined for three main?Lactobacillus?strains (L. crispatus,?L. gasseri?and?L. jensenii). Results: The MICs of the antibiotics and antifungal agents were above their critical concentrations in the three strains, contrary to the antiseptics. According to their MID, some pharmaceutical products, especially combinations, inhibit the growth of one or more strains at concentrations that can be found in the vaginal mucosa after application at the usual dosage. Conclusions: Certain topical anti-infective drugs may interfere with the growth of lactobacilli, worsening the vaginal flora imbalance. Maintaining vaginal flora balance should be a selection criterion when choosing an anti-infective therapy.展开更多
From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 pat...From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 patients treated with Canesten alone. The therapeutic results were satisfactory and reported as follows.展开更多
Background: Vaginitis is an important public health problem globally. It is associated with gynaecological and obstetric complications. Vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis are ma...Background: Vaginitis is an important public health problem globally. It is associated with gynaecological and obstetric complications. Vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis are mainly responsible for vaginitis. The aim of this study is to determine the occurrence, clinical characteristics and associated risk factors of vulvovaginal candidiasis and bacterial vaginosis among women of reproductive age attending Primary Health Care centres in Lagos Nigeria. Methods:This cross-sectional study recruited 258 women with genital complaints after obtaining their informed written consent between May 2017 and March 2018. Structured questionnaires were administered and high vaginal swabs were collected for laboratory examination. The results were analysed with descriptive statistics, chi-square and simple logistic regression. Results: Out of the 210 (81.4%) of the women with one or more vaginal infections, 105 (50.0%), 26 (12.4%) had bacterial vaginosis, and vulvovaginal candidiasis respectively while 78 (37.1%) had both vulvovaginal candidiasis and bacterial vaginosis. Only 1 (0.5%) participant had trichomoniasis and bacterial vaginosis. History of abortion and age below 25 years were associated with vulvovaginal candidiasis while pregnancy, history of miscarriage, age at first sexual activity and discharge were associated with bacterial vaginosis. Itching was associated with both vulvovaginal candidiasis and bacterial vaginosis. Conclusion: This study revealed vulvovaginal candidiasis and bacterial vaginosis as important cause of genital complaints among reproductive age women in Lagos. Health education, robust diagnosis and early treatment are needed in order to reduce the associated risk factors, disease burden and complications.展开更多
The most frequent cause of visits to the gynecologist in the western world is vaginal discomfort (vaginitis and vaginosis) whose origin lies in the uncontrolled proliferation of bacteria, such as haemophilus vaginalis...The most frequent cause of visits to the gynecologist in the western world is vaginal discomfort (vaginitis and vaginosis) whose origin lies in the uncontrolled proliferation of bacteria, such as haemophilus vaginalis or Candida-type fungi, normally considered as saprophytes. Such uncontrolled development of saprophytes is caused by some types of aggression against?Doderlein bacilli and/or by a significant decrease in the amount of lactic acid (use of broad-spectrum antibiotics, douches with aggressive products, etc.). Consequently, as the vagina creates a progressively alkalinized and increasingly inadequate environment for the lactobacilli activity, a more favorable environment for the growth of saprophytes is created. The more alkaline the medium becomes, the lower the production of lactic acid. Therefore a vicious circle is created, resulting in the bacillus acidophilus near the lack of metabolism and the disappearance of lactic acid, hydrogen peroxide and bacteriocins. All of the above make it possible for saprophytic bacteria to proliferate and become pathogenic. So far, all vaginitis and vaginosis treatments have solely been focused on attacking the disproportionately developed bacteria but have not addressed the restoration of a vaginal acidic environment, i.e. the environment allowing the proliferation of lactic acid-producing bacillus acidophilus. This explains the high rate of relapse occurring after the treatment of these vaginal profiles. In this paper we propose a new treatment focused on the use of lactic acid to prevent recurrence after a vaginitis or vaginosis treatment.展开更多
Background: The aerobic vaginitis (AV) is characterized by increased levels of aerobic bacteria, vaginal inflammation and depressed levels of lactobacilli. Objective: The purpose of this study was to investigate the t...Background: The aerobic vaginitis (AV) is characterized by increased levels of aerobic bacteria, vaginal inflammation and depressed levels of lactobacilli. Objective: The purpose of this study was to investigate the therapeutic efficacy of SilTech<sup>TM</sup> vaginal softgel capsules, containing new microcrystals of silver monovalent ions, for aerobic vaginitis (AV). Methods: This prospective study enrolled 32 women diagnosed with AV. All recruited women were treated with SilTech<sup>TM</sup> vaginal softgel capsules once daily for 7 days (one course). Therapeutic efficacy was evaluated based on clinical and microscopic criteria, and cure rates were calculated. Women who were improved (but not cured) received a second course of therapy. Patients classified with clinical and microscopic failure were treated using other strategies. Results: After one course of therapy, 59.2% (19/32) of women were cured, 19.0% (6/32) were improved (but not cured) and 21.8% (7/32) failed to respond to the therapy. After two courses of therapy, clinical improvement was achieved in additional two women. The therapy was very well tolerated, and during the entire study no drop out related to the SylTech<sup>TM</sup> vaginal capsules treatment was observed;only two patients (6.2%) experienced a mild transient burning after application. Conclusion: SylTech<sup>TM</sup> vaginal capsules is an effective therapeutic option for patients with AV, and most women with AV were cured with one course of therapy.展开更多
The article records details of the treatment process and efect of an elderly patient with senile vaginitis,where needling,a method of Chinese Traditional Medicine(TCM)method,was applied mainly,combined with oral admin...The article records details of the treatment process and efect of an elderly patient with senile vaginitis,where needling,a method of Chinese Traditional Medicine(TCM)method,was applied mainly,combined with oral administration of western medicine.It then analyses this disease from prospective of TCM.In the end,it concludes that no matter traditional needling method or traditional needling method combined with moxibustion,it has achieved a satisfied treatment effect while applying needling on chosen acupuncture points,so it is worthy being further popularized.展开更多
Aim To research therapeutical effect of marine lysozyme suppository on bacterial vaginitis caused by S. aureus and E. coll. Methods Lysozyme obtained from concha ostreae which were used to preparate marine lyso- zyme ...Aim To research therapeutical effect of marine lysozyme suppository on bacterial vaginitis caused by S. aureus and E. coll. Methods Lysozyme obtained from concha ostreae which were used to preparate marine lyso- zyme suppository. The identification and test of suppository was in line with the standards stated in Chinese pharma- coperia（2010 edition）. After determined its quality control, we studied its therapeutical effect on bacterial vaginitis which caused by S. aureus and E. coli, by vaginitis model in rats infection of S. aureus bacteria and E. coli. Results The preparation technology of marine lysozyme suppository was simple, convenient and clinically effective. The marine lysozyme suppository was delivered by dose 0.5, 0.25, 0. 125 g ~ kg-1, the cure rates of S. aureus infec- tion were 80% , 50% and 30% , respectively, the cure rates of E. coli infection were 90% , 60% and 30% re- spectively, the cure rates of mixed infection were 92.9% , 82. 1% and 92.9% respectively. Marine lysozyme sup- pository had an outstanding therapeutical effect on bacterial vaginitis which caused by S. aureus and E. coll. Con- clusion The preparative process of marine lysozyme suppository was practicable, and it had a good therapeutic effect on bacterial vaginitis caused by S. aureus and E. coll.展开更多
Objectives: This study aimed to assess clinical, microbial changes in IUD users and other contraceptive methods in referent to urban health centers in Hamadan city, Iran. Methods: Detailed history and gynecological ex...Objectives: This study aimed to assess clinical, microbial changes in IUD users and other contraceptive methods in referent to urban health centers in Hamadan city, Iran. Methods: Detailed history and gynecological examination were conducted on women (IUD users, n = 100) or other contraceptive methods (controls, n = 160) in the health centers. Results: Frequencies of the different vaginal pathogens, high indices of infection by bacterial vaginosis (12.0%) candida albicance (7.0%) and low indices of trichomoniasis (5.0%) were found in present study, but none of them in both groups was significant. Menorrhagia was more frequent among women with IUD than that among women without IUD (P < 0.05). A trend of erosion cervix and dysmenorrhea being more frequent among women with IUD was also found (P < 0.05). Conclusions: IUD is the safety in general;however, an increase occurred in the frequency of vaginitis.展开更多
The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double bli...The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weight hyaluronic acid (HA) oral tablets or placebo for three months. Vaginal biopsies were taken at baseline and after three months of treatment, and vaginal epithelium was analysed using light microscopy. The evaluation of symptoms was self-assessed by the patients. Biopsies from HA group showed an epithelium thicker than in placebo group. The lamina propria from the HA group also showed a denser appearance compared to placebo group. Morphometric analysis showed significant differences between HA and baseline in the number of epithelial layers and in the thickness. The evaluation of symptoms also showed an effective improvement in the patients treated with HA, compared to baseline and to placebo group. In conclusion, oral administration of HA tablets improved the vaginal epithelium, decreasing atrophy. This can be an ideal option for patients with atrophic vaginitis who do not want to or can not take estrogen and show low compliance toward vaginal administration.展开更多
Objective: To realize the effect and clinical value of implementing oral metronidazole + miconazole nitrate in patients with recurrent vaginosis. Methods: This study was analyzed retrospectively, and the time period w...Objective: To realize the effect and clinical value of implementing oral metronidazole + miconazole nitrate in patients with recurrent vaginosis. Methods: This study was analyzed retrospectively, and the time period was controlled from April 2020 to August 2021.200 consecutive patients with recurrent candida vaginitis in our hospital were admitted and randomized, and 100 consecutive patients were included in each group. The control group was given metronidazole treatment, and the observation group used miconazole nitrate based on the control group. The disease recurrence rate, incidence of adverse reactions, time to clinical symptom improvement, clinical efficacy, Candida clearance rate, and vaginal health status were observed and compared. Results: The clinical efficacy of the observed group was 97.00%, the incidence of adverse reactions was only 3.00%, 88.00% and 11.00% of the control groups, respectively, and P 0.05. In the observation group treated with combination therapy, the patients had a short improvement time of clinical symptoms, a good vaginal health status, and a high vaginal cleanliness, with P 0.05. Patients in the post-treatment observation group had higher Candida clearance and lower disease recurrence rate, and the data were P 0.05 compared to the control group. Conclusion: Oral metronidazole plus miconazole nitrate in treating recurrent candida vaginitis can shorten the clinical symptoms, improve the vaginal health and improve the clinical effect.展开更多
Objective: to study the application effect of nitrocellulose vaginal soft capsule (blue) in the clinical treatment of vaginitis. Methods: select our hospital during May 2020 to April 202160 vaginitis patients, even pa...Objective: to study the application effect of nitrocellulose vaginal soft capsule (blue) in the clinical treatment of vaginitis. Methods: select our hospital during May 2020 to April 202160 vaginitis patients, even patients, observation and control group 30 cases, control group using conventional treatment plan, observation group auxiliary treatment, compare the two groups of patients treatment efficiency, recurrence rate and incidence of adverse reactions, analyze the treatment cycle and patient satisfaction score. Results: the total treatment efficiency of the observation group was 96.67% (29 / 30), The total treatment efficiency of the control group was 70.00% (21 / 30), Data vary between groups, Statistical significance;The recurrence rate of vaginitis in the observation group was 3.33% (1 in 30), The control group's recurrence rate was 26.67% (8 / 30), Statistical significance (P <0.05);Two cases had heartburn, itching and one case who had nausea in the observation group;The control group had 4 cases of external heartburn, itching and 4 cases of nausea, There were 3 cases of dizziness, The incidence of adverse reactions in the observed group was 10.00% lower than 36.67% in the control group, Comparison between groups were obvious, Statistically significant (P <0.05).Treatment cycle (20.41 ± 2.28) d, satisfaction score (94.35 ± 2.08), treatment cycle (22.23 ± 3.12) d, satisfaction score (93.42 ± 1.150), P <0.05 after data comparison. Conclusion: in the clinical treatment of vaginitis, the use of nitrofurthil ycin is very effective, which can improve the overall efficiency of treatment and control the incidence of disease recurrence and adverse reactions. Relevant treatment methods are also conducive to shortening the rehabilitation treatment cycle and improving the patient satisfaction score, which is of great significance to accelerate the treatment process of patients, and can be promoted.展开更多
Objective: to analyze the specific effect of the implementation of high-quality care of lactobacillus vaginal capsules on vaginitis combined with relevant specific methods. Methods: the experimental subjects of this s...Objective: to analyze the specific effect of the implementation of high-quality care of lactobacillus vaginal capsules on vaginitis combined with relevant specific methods. Methods: the experimental subjects of this study were 80 patients with vaginitis who were treated in our hospital from 2020 to January 2021. These patients were divided into two groups with 40 in each group according to different nursing methods, and were divided into the control group and the observation group. The two groups of patients were treated with lactobacillus vaginal capsules, but the control group was treated with conventional care, while the observation group was treated with high-quality care. The incidence rate of adverse physical reactions, patients' compliance and the related curative effect of the two groups of patients after different care were analyzed with different care. Results: according to the correlation to achieve statistical comparison of data, the compliance rate of patients in the observation group is more advantageous than that of the control group, and the incidence rate of adverse reactions of patients in the observation group is also lower, and the comparative difference between the two groups is also statistically significant (p<0.05). Conclusion: the combination of lactobacillus vaginal capsule and high-quality care in vaginitis has a positive effect in improving the efficiency and compliance of patients, with fewer adverse reactions, and is worthy of recommendation in clinical practice.展开更多
Objective: in the process of testing Candida vaginitis patients to take different microbiological test methods, mainly to observe the effect of vaginal secretion test.Methods: a total of 84 patients diagnosed with can...Objective: in the process of testing Candida vaginitis patients to take different microbiological test methods, mainly to observe the effect of vaginal secretion test.Methods: a total of 84 patients diagnosed with candida vaginitis were enrolled in this study. The vaginal secretions of the patients were examined by microscopy, culture and agglutination, and the results were compared.Results: compared with culture method and agglutination method, the positive detection rate of microscopy method was higher, the difference was significant (P < 0.05).Conclusion: microscopic examination can achieve good results in the examination of vaginal secretions in patients with candida vaginitis, and it can improve the detection rate of candida. This method is worthy of popularization and application.展开更多
Objective: to analyze the value of nystatin combined with lactobacillus in the treatment of mycotic vaginitis. Methods: 40 cases of mycotic vaginitis admitted to our hospital from February 2019 to May 2021 were includ...Objective: to analyze the value of nystatin combined with lactobacillus in the treatment of mycotic vaginitis. Methods: 40 cases of mycotic vaginitis admitted to our hospital from February 2019 to May 2021 were included. They were divided into the study group and the control group (20 cases in each group) by random number table method, and all received conventional treatment. The study group was also treated with nystatin combined with lactobacillus, and the treatment between the groups was evaluated and compared. Results: after treatment, the therapeutic effect of the study group was better than the control group, and the level of inflammatory factors was lower than the control group, the differences were statistically significant (P < 0.05). Conclusion: nystatin combined with lactic acid bacteria in the treatment of mycotic vaginitis is helpful to improve the curative effect and inflammatory factors, and has outstanding application value.展开更多
Objective: to explore the effect of nursing intervention in the treatment of fungal vaginitis. Methods: 160 patients with fungal vaginitis who received treatment in our hospital from June 2018 to June 2020 were select...Objective: to explore the effect of nursing intervention in the treatment of fungal vaginitis. Methods: 160 patients with fungal vaginitis who received treatment in our hospital from June 2018 to June 2020 were selected as the research subjects. All patients were divided into average groups by random number table method. 80 patients in the control group only received conventional drug treatment, and 80 patients in the experimental group received nursing intervention on this basis. The treatment effect and recurrence of the two groups of patients were compared. Results: the total effective rate of the experimental group was significantly higher than that of the control group, and the recurrence rate of the experimental group was significantly lower than that of the control group, the difference between the two groups was statistically significant (P < 0.05). Conclusion: nursing intervention in the treatment of patients with fungal vaginitis has a definite application effect, can improve the total effective rate of treatment, reduce the rate of disease recurrence, and can be used reasonably in clinical treatment.展开更多
Objective: the experiment will be for patients with mycotic vaginitis to implement traditional Chinese medicine treatment, to add or reduce Longdan Xiegan decoction combined with traditional Chinese medicine fumigatio...Objective: the experiment will be for patients with mycotic vaginitis to implement traditional Chinese medicine treatment, to add or reduce Longdan Xiegan decoction combined with traditional Chinese medicine fumigation treatment as the main form, to analyze the clinical application effect. Methods: in this study, patients with mycotic vaginitis were selected as the main body of the investigation. In the time period, patients admitted from June 2019 to May 2020 were intersected. By using random number method, they were divided into two groups for comparative investigation, and the changes of the conditions of 70 patients were recorded. The control group was treated with traditional Chinese medicine fumigation and washing, while the observation group was treated with the addition and subtraction of Longdan Xiegan Decoction combined with traditional Chinese medicine fumigation and washing. Results: in terms of treatment quality, the total therapeutic effect rate of the observation group was 94.3%, and that of the control group was 77.1%, with significant difference between groups (P < 0.05). Meanwhile, in the investigation of recurrence, the recurrence rate of observation group was 5.7% (2/35), which was significantly lower than that of control group (20.0%, 7/35), and the difference was statistically significant (P < 0.05). Conclusion: the treatment program of adding or subtracting Longdan Xiegan Decoction combined with traditional Chinese medicine fumigation and washing is helpful to the recovery of patients with mycotic vaginitis and prevention of disease recurrence, which has the significance of popularization.展开更多
Objective: to study the clinical effect of tenidazole plug and estrogen ointment in the treatment of senile vaginitis. Methods: from February 2020 to February 2022, 98 patients with senile vaginitis admitted to our ho...Objective: to study the clinical effect of tenidazole plug and estrogen ointment in the treatment of senile vaginitis. Methods: from February 2020 to February 2022, 98 patients with senile vaginitis admitted to our hospital were selected as the research subjects, and 98 patients were divided into observation group (49 cases) and control group (49 cases). The control group was treated with tenidazole plug, and the observation group underwent combination therapy with tenidazole plugs and estrogen ointment. Comparatively analyze the two groups. Results: the treatment efficiency, hormone level, vaginitis symptom score and inflammatory factor index were all better than the control group (P 0.05), and no significant difference between the two groups (P> 0.05). Conclusion: geriatric vaginitis is a common disease in elderly women. Due to the lack of estrogen secretion, the vaginal environment is changed, and the vaginal pH value increases, which is conducive to the reproduction of bacteria. Therefore, the disease is often refractory, repeated attacks;affect the life. The use of tenidazole plug and estrogen ointment to treat senile vaginitis can adjust the hormone level of patients, improve the vaginal environment, and inhibit the reproduction of bacteria, so as to achieve good clinical effect.展开更多
文摘Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.
文摘Objective: To evaluate the efficacy and tolerance of a local treatment combining two antibacterials and one antifungal in patients with a clinical presentation suggesting infectious vaginitis. Patients and methods: 169 patients presenting with clinical criteria for vaginitis were included in an open, multicenter trial. Vaginal samples were taken for microbiological analyses and a triple-combination product of nystatin, neomycin and polymyxin B was then started as local treatment, without waiting for the test results. The treatment was continued with the usual dosage (1 vaginal capsule at bedtime for 12 days) for vaginal infections in the scope of the combination product with approved labeling. A second vaginal sample was performed at the end of the treatment. The main efficacy criterion was the clinical success rate (cure or improvement of the clinical signs and symptoms) according to the investigator.Results: 93 patients were included in the efficacy population. Non-exclusively fungal vaginitis (strictly bacterial or bacterial + fungal) represented 31.2% of the cases. The clinical success rate was 97.8% according to the investigator and 95.7% according to the patients. The microbiological success rate was 81.3%, with no differences between etiologies (Candida spp., bacteria or both). The combination product was well-tolerated, despite the local inflammation before treatment. Discussion and conclusion: Given the etiological diversity of vaginitis, this trial supports the efficacy of a triple-combination product (nystatin, neomycin, polymyxin B) as a first-line local treatment of Candida, bacterial or mixed vaginitis.
文摘Objective To investigate IUD-related vaginitis in IUD users at the University College Hospital Ibadan, South-western Nigeria.Methods A prospective cohort study in IUD users present with abnormal vaginal discharge at the family planning clinic of the University College Hospital, Ibadan was conducted between lOth of October, 2008 and 31st of May 2009. High Vaginal Swabs were taken from the clients for microbiology, culture and drug sensitivity test. Diagnosis of bacterial vaginosis was made based on gram stained vaginal smear using the standard Nugents criteria. Other aetiological agents were identified either on wet preparation or culture using standard techniques. Treatment given was by the family planning nurse, as was the protocol at the family planning clinic.Results Twenty-four IUD users present at the Jamtty ptannmg ctmtc with vaginal discharge were studied. Their ages ranged 28-51 years（38.14 ± 5.9 years）, Mean parity was 4.4 ± 1.4, All the women were married and all used CuT 380A. The mean duration of lUCD use was 2.5 years only. Majority （46%） had used it for more than 3 years and most （75%） of the visits were unscheduled. All the clients complained of abnormal vaginal discharge which was copious, watery and foul smelling, or clumpy. Nine users （37.5%） complained of pruritus vulvae, 3 users （12.5%） lower abdominal pain, 1 user （4,2%） dyspareunia and vaginosis was made in 16 （66. 7%） and 1 （4.2%） dysuria. The diagnosis of bacterial vaginal candidiasis in 8 （33.3%）. Age less than 40 years, Christianity and IUD use more than 3 years were associated with a higher risk of bacterial vaginosis （OR=1.29, 1.67 and 6.6, respectively）, while women above 40 years, Muslims and women with lower educational status had a higher risk of candida-related vaginitis （OR=1.67 and 4.2, respectively）. Eight clients （33.3%） were treated for candidiasis with antifungals （3 empirically, and 5 after obtaining results of vaginal swab）, 9 （37.5%） were given oral metronidazole, 3 patients were referred to the gynaecological emergency unit on account of abdominal pain and 4 did not return for follow up.Conclusion IUD associated vaginitis is a disturbing condition causing unscheduled visits among IUD users. Bacterial vaginosis and Candidia albicans are major aetiologies in south western Nigeria Ibadan. Persistent discharge is a documented reason for discontinuation of lUD use. Periodic empirical treatment for candidiasis and bacterial vaginosis with antifungals and oral metronidazole is advocated. This may reduce the discomfort caused by IUD-related vaginitis, the risk of PID and other risks exposed to the IUD users and ensure continued use of the IUD.
文摘Objectives: The balance of the vaginal ecosystem depends on lactobacilli whose biofilm protectsagainst microorganisms that are not normally present or are subdominant in vaginal flora. Vaginal?infection treatments should eliminate pathogens while preserving the?Lactobacillus?flora to prevent relapse or recurrence. The objective of this study was to determine the sensitivity of lactobacilli to antiseptics, antibiotics and antifungal agents used, alone or in combination, in the topical treatment of infectious vaginitis. Materials and Methods: The minimum inhibitory concentration (MIC) of 15 active ingredients and the minimum inhibitory dilution (MID) of 17 pharmaceuticals products were determined for three main?Lactobacillus?strains (L. crispatus,?L. gasseri?and?L. jensenii). Results: The MICs of the antibiotics and antifungal agents were above their critical concentrations in the three strains, contrary to the antiseptics. According to their MID, some pharmaceutical products, especially combinations, inhibit the growth of one or more strains at concentrations that can be found in the vaginal mucosa after application at the usual dosage. Conclusions: Certain topical anti-infective drugs may interfere with the growth of lactobacilli, worsening the vaginal flora imbalance. Maintaining vaginal flora balance should be a selection criterion when choosing an anti-infective therapy.
文摘From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 patients treated with Canesten alone. The therapeutic results were satisfactory and reported as follows.
文摘Background: Vaginitis is an important public health problem globally. It is associated with gynaecological and obstetric complications. Vulvovaginal candidiasis, bacterial vaginosis and trichomoniasis are mainly responsible for vaginitis. The aim of this study is to determine the occurrence, clinical characteristics and associated risk factors of vulvovaginal candidiasis and bacterial vaginosis among women of reproductive age attending Primary Health Care centres in Lagos Nigeria. Methods:This cross-sectional study recruited 258 women with genital complaints after obtaining their informed written consent between May 2017 and March 2018. Structured questionnaires were administered and high vaginal swabs were collected for laboratory examination. The results were analysed with descriptive statistics, chi-square and simple logistic regression. Results: Out of the 210 (81.4%) of the women with one or more vaginal infections, 105 (50.0%), 26 (12.4%) had bacterial vaginosis, and vulvovaginal candidiasis respectively while 78 (37.1%) had both vulvovaginal candidiasis and bacterial vaginosis. Only 1 (0.5%) participant had trichomoniasis and bacterial vaginosis. History of abortion and age below 25 years were associated with vulvovaginal candidiasis while pregnancy, history of miscarriage, age at first sexual activity and discharge were associated with bacterial vaginosis. Itching was associated with both vulvovaginal candidiasis and bacterial vaginosis. Conclusion: This study revealed vulvovaginal candidiasis and bacterial vaginosis as important cause of genital complaints among reproductive age women in Lagos. Health education, robust diagnosis and early treatment are needed in order to reduce the associated risk factors, disease burden and complications.
文摘The most frequent cause of visits to the gynecologist in the western world is vaginal discomfort (vaginitis and vaginosis) whose origin lies in the uncontrolled proliferation of bacteria, such as haemophilus vaginalis or Candida-type fungi, normally considered as saprophytes. Such uncontrolled development of saprophytes is caused by some types of aggression against?Doderlein bacilli and/or by a significant decrease in the amount of lactic acid (use of broad-spectrum antibiotics, douches with aggressive products, etc.). Consequently, as the vagina creates a progressively alkalinized and increasingly inadequate environment for the lactobacilli activity, a more favorable environment for the growth of saprophytes is created. The more alkaline the medium becomes, the lower the production of lactic acid. Therefore a vicious circle is created, resulting in the bacillus acidophilus near the lack of metabolism and the disappearance of lactic acid, hydrogen peroxide and bacteriocins. All of the above make it possible for saprophytic bacteria to proliferate and become pathogenic. So far, all vaginitis and vaginosis treatments have solely been focused on attacking the disproportionately developed bacteria but have not addressed the restoration of a vaginal acidic environment, i.e. the environment allowing the proliferation of lactic acid-producing bacillus acidophilus. This explains the high rate of relapse occurring after the treatment of these vaginal profiles. In this paper we propose a new treatment focused on the use of lactic acid to prevent recurrence after a vaginitis or vaginosis treatment.
文摘Background: The aerobic vaginitis (AV) is characterized by increased levels of aerobic bacteria, vaginal inflammation and depressed levels of lactobacilli. Objective: The purpose of this study was to investigate the therapeutic efficacy of SilTech<sup>TM</sup> vaginal softgel capsules, containing new microcrystals of silver monovalent ions, for aerobic vaginitis (AV). Methods: This prospective study enrolled 32 women diagnosed with AV. All recruited women were treated with SilTech<sup>TM</sup> vaginal softgel capsules once daily for 7 days (one course). Therapeutic efficacy was evaluated based on clinical and microscopic criteria, and cure rates were calculated. Women who were improved (but not cured) received a second course of therapy. Patients classified with clinical and microscopic failure were treated using other strategies. Results: After one course of therapy, 59.2% (19/32) of women were cured, 19.0% (6/32) were improved (but not cured) and 21.8% (7/32) failed to respond to the therapy. After two courses of therapy, clinical improvement was achieved in additional two women. The therapy was very well tolerated, and during the entire study no drop out related to the SylTech<sup>TM</sup> vaginal capsules treatment was observed;only two patients (6.2%) experienced a mild transient burning after application. Conclusion: SylTech<sup>TM</sup> vaginal capsules is an effective therapeutic option for patients with AV, and most women with AV were cured with one course of therapy.
文摘The article records details of the treatment process and efect of an elderly patient with senile vaginitis,where needling,a method of Chinese Traditional Medicine(TCM)method,was applied mainly,combined with oral administration of western medicine.It then analyses this disease from prospective of TCM.In the end,it concludes that no matter traditional needling method or traditional needling method combined with moxibustion,it has achieved a satisfied treatment effect while applying needling on chosen acupuncture points,so it is worthy being further popularized.
文摘Aim To research therapeutical effect of marine lysozyme suppository on bacterial vaginitis caused by S. aureus and E. coll. Methods Lysozyme obtained from concha ostreae which were used to preparate marine lyso- zyme suppository. The identification and test of suppository was in line with the standards stated in Chinese pharma- coperia（2010 edition）. After determined its quality control, we studied its therapeutical effect on bacterial vaginitis which caused by S. aureus and E. coli, by vaginitis model in rats infection of S. aureus bacteria and E. coli. Results The preparation technology of marine lysozyme suppository was simple, convenient and clinically effective. The marine lysozyme suppository was delivered by dose 0.5, 0.25, 0. 125 g ~ kg-1, the cure rates of S. aureus infec- tion were 80% , 50% and 30% , respectively, the cure rates of E. coli infection were 90% , 60% and 30% re- spectively, the cure rates of mixed infection were 92.9% , 82. 1% and 92.9% respectively. Marine lysozyme sup- pository had an outstanding therapeutical effect on bacterial vaginitis which caused by S. aureus and E. coll. Con- clusion The preparative process of marine lysozyme suppository was practicable, and it had a good therapeutic effect on bacterial vaginitis caused by S. aureus and E. coll.
文摘Objectives: This study aimed to assess clinical, microbial changes in IUD users and other contraceptive methods in referent to urban health centers in Hamadan city, Iran. Methods: Detailed history and gynecological examination were conducted on women (IUD users, n = 100) or other contraceptive methods (controls, n = 160) in the health centers. Results: Frequencies of the different vaginal pathogens, high indices of infection by bacterial vaginosis (12.0%) candida albicance (7.0%) and low indices of trichomoniasis (5.0%) were found in present study, but none of them in both groups was significant. Menorrhagia was more frequent among women with IUD than that among women without IUD (P < 0.05). A trend of erosion cervix and dysmenorrhea being more frequent among women with IUD was also found (P < 0.05). Conclusions: IUD is the safety in general;however, an increase occurred in the frequency of vaginitis.
文摘The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weight hyaluronic acid (HA) oral tablets or placebo for three months. Vaginal biopsies were taken at baseline and after three months of treatment, and vaginal epithelium was analysed using light microscopy. The evaluation of symptoms was self-assessed by the patients. Biopsies from HA group showed an epithelium thicker than in placebo group. The lamina propria from the HA group also showed a denser appearance compared to placebo group. Morphometric analysis showed significant differences between HA and baseline in the number of epithelial layers and in the thickness. The evaluation of symptoms also showed an effective improvement in the patients treated with HA, compared to baseline and to placebo group. In conclusion, oral administration of HA tablets improved the vaginal epithelium, decreasing atrophy. This can be an ideal option for patients with atrophic vaginitis who do not want to or can not take estrogen and show low compliance toward vaginal administration.
文摘Objective: To realize the effect and clinical value of implementing oral metronidazole + miconazole nitrate in patients with recurrent vaginosis. Methods: This study was analyzed retrospectively, and the time period was controlled from April 2020 to August 2021.200 consecutive patients with recurrent candida vaginitis in our hospital were admitted and randomized, and 100 consecutive patients were included in each group. The control group was given metronidazole treatment, and the observation group used miconazole nitrate based on the control group. The disease recurrence rate, incidence of adverse reactions, time to clinical symptom improvement, clinical efficacy, Candida clearance rate, and vaginal health status were observed and compared. Results: The clinical efficacy of the observed group was 97.00%, the incidence of adverse reactions was only 3.00%, 88.00% and 11.00% of the control groups, respectively, and P 0.05. In the observation group treated with combination therapy, the patients had a short improvement time of clinical symptoms, a good vaginal health status, and a high vaginal cleanliness, with P 0.05. Patients in the post-treatment observation group had higher Candida clearance and lower disease recurrence rate, and the data were P 0.05 compared to the control group. Conclusion: Oral metronidazole plus miconazole nitrate in treating recurrent candida vaginitis can shorten the clinical symptoms, improve the vaginal health and improve the clinical effect.
文摘Objective: to study the application effect of nitrocellulose vaginal soft capsule (blue) in the clinical treatment of vaginitis. Methods: select our hospital during May 2020 to April 202160 vaginitis patients, even patients, observation and control group 30 cases, control group using conventional treatment plan, observation group auxiliary treatment, compare the two groups of patients treatment efficiency, recurrence rate and incidence of adverse reactions, analyze the treatment cycle and patient satisfaction score. Results: the total treatment efficiency of the observation group was 96.67% (29 / 30), The total treatment efficiency of the control group was 70.00% (21 / 30), Data vary between groups, Statistical significance;The recurrence rate of vaginitis in the observation group was 3.33% (1 in 30), The control group's recurrence rate was 26.67% (8 / 30), Statistical significance (P <0.05);Two cases had heartburn, itching and one case who had nausea in the observation group;The control group had 4 cases of external heartburn, itching and 4 cases of nausea, There were 3 cases of dizziness, The incidence of adverse reactions in the observed group was 10.00% lower than 36.67% in the control group, Comparison between groups were obvious, Statistically significant (P <0.05).Treatment cycle (20.41 ± 2.28) d, satisfaction score (94.35 ± 2.08), treatment cycle (22.23 ± 3.12) d, satisfaction score (93.42 ± 1.150), P <0.05 after data comparison. Conclusion: in the clinical treatment of vaginitis, the use of nitrofurthil ycin is very effective, which can improve the overall efficiency of treatment and control the incidence of disease recurrence and adverse reactions. Relevant treatment methods are also conducive to shortening the rehabilitation treatment cycle and improving the patient satisfaction score, which is of great significance to accelerate the treatment process of patients, and can be promoted.
文摘Objective: to analyze the specific effect of the implementation of high-quality care of lactobacillus vaginal capsules on vaginitis combined with relevant specific methods. Methods: the experimental subjects of this study were 80 patients with vaginitis who were treated in our hospital from 2020 to January 2021. These patients were divided into two groups with 40 in each group according to different nursing methods, and were divided into the control group and the observation group. The two groups of patients were treated with lactobacillus vaginal capsules, but the control group was treated with conventional care, while the observation group was treated with high-quality care. The incidence rate of adverse physical reactions, patients' compliance and the related curative effect of the two groups of patients after different care were analyzed with different care. Results: according to the correlation to achieve statistical comparison of data, the compliance rate of patients in the observation group is more advantageous than that of the control group, and the incidence rate of adverse reactions of patients in the observation group is also lower, and the comparative difference between the two groups is also statistically significant (p<0.05). Conclusion: the combination of lactobacillus vaginal capsule and high-quality care in vaginitis has a positive effect in improving the efficiency and compliance of patients, with fewer adverse reactions, and is worthy of recommendation in clinical practice.
文摘Objective: in the process of testing Candida vaginitis patients to take different microbiological test methods, mainly to observe the effect of vaginal secretion test.Methods: a total of 84 patients diagnosed with candida vaginitis were enrolled in this study. The vaginal secretions of the patients were examined by microscopy, culture and agglutination, and the results were compared.Results: compared with culture method and agglutination method, the positive detection rate of microscopy method was higher, the difference was significant (P < 0.05).Conclusion: microscopic examination can achieve good results in the examination of vaginal secretions in patients with candida vaginitis, and it can improve the detection rate of candida. This method is worthy of popularization and application.
文摘Objective: to analyze the value of nystatin combined with lactobacillus in the treatment of mycotic vaginitis. Methods: 40 cases of mycotic vaginitis admitted to our hospital from February 2019 to May 2021 were included. They were divided into the study group and the control group (20 cases in each group) by random number table method, and all received conventional treatment. The study group was also treated with nystatin combined with lactobacillus, and the treatment between the groups was evaluated and compared. Results: after treatment, the therapeutic effect of the study group was better than the control group, and the level of inflammatory factors was lower than the control group, the differences were statistically significant (P < 0.05). Conclusion: nystatin combined with lactic acid bacteria in the treatment of mycotic vaginitis is helpful to improve the curative effect and inflammatory factors, and has outstanding application value.
文摘Objective: to explore the effect of nursing intervention in the treatment of fungal vaginitis. Methods: 160 patients with fungal vaginitis who received treatment in our hospital from June 2018 to June 2020 were selected as the research subjects. All patients were divided into average groups by random number table method. 80 patients in the control group only received conventional drug treatment, and 80 patients in the experimental group received nursing intervention on this basis. The treatment effect and recurrence of the two groups of patients were compared. Results: the total effective rate of the experimental group was significantly higher than that of the control group, and the recurrence rate of the experimental group was significantly lower than that of the control group, the difference between the two groups was statistically significant (P < 0.05). Conclusion: nursing intervention in the treatment of patients with fungal vaginitis has a definite application effect, can improve the total effective rate of treatment, reduce the rate of disease recurrence, and can be used reasonably in clinical treatment.
文摘Objective: the experiment will be for patients with mycotic vaginitis to implement traditional Chinese medicine treatment, to add or reduce Longdan Xiegan decoction combined with traditional Chinese medicine fumigation treatment as the main form, to analyze the clinical application effect. Methods: in this study, patients with mycotic vaginitis were selected as the main body of the investigation. In the time period, patients admitted from June 2019 to May 2020 were intersected. By using random number method, they were divided into two groups for comparative investigation, and the changes of the conditions of 70 patients were recorded. The control group was treated with traditional Chinese medicine fumigation and washing, while the observation group was treated with the addition and subtraction of Longdan Xiegan Decoction combined with traditional Chinese medicine fumigation and washing. Results: in terms of treatment quality, the total therapeutic effect rate of the observation group was 94.3%, and that of the control group was 77.1%, with significant difference between groups (P < 0.05). Meanwhile, in the investigation of recurrence, the recurrence rate of observation group was 5.7% (2/35), which was significantly lower than that of control group (20.0%, 7/35), and the difference was statistically significant (P < 0.05). Conclusion: the treatment program of adding or subtracting Longdan Xiegan Decoction combined with traditional Chinese medicine fumigation and washing is helpful to the recovery of patients with mycotic vaginitis and prevention of disease recurrence, which has the significance of popularization.
文摘Objective: to study the clinical effect of tenidazole plug and estrogen ointment in the treatment of senile vaginitis. Methods: from February 2020 to February 2022, 98 patients with senile vaginitis admitted to our hospital were selected as the research subjects, and 98 patients were divided into observation group (49 cases) and control group (49 cases). The control group was treated with tenidazole plug, and the observation group underwent combination therapy with tenidazole plugs and estrogen ointment. Comparatively analyze the two groups. Results: the treatment efficiency, hormone level, vaginitis symptom score and inflammatory factor index were all better than the control group (P 0.05), and no significant difference between the two groups (P> 0.05). Conclusion: geriatric vaginitis is a common disease in elderly women. Due to the lack of estrogen secretion, the vaginal environment is changed, and the vaginal pH value increases, which is conducive to the reproduction of bacteria. Therefore, the disease is often refractory, repeated attacks;affect the life. The use of tenidazole plug and estrogen ointment to treat senile vaginitis can adjust the hormone level of patients, improve the vaginal environment, and inhibit the reproduction of bacteria, so as to achieve good clinical effect.
