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基于VIP/cAMP/Epac信号通路探讨星状神经节埋线对哮喘模型大鼠的作用机制
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作者 张莹 程燕 +1 位作者 董佳雯 王珏 《江苏中医药》 2026年第1期72-76,共5页
目的:探讨星状神经节埋线通过血管活性肠肽(VIP)/环腺苷酸(cAMP)/cAMP直接激活的交换蛋白(Epac)信号通路对哮喘模型大鼠的干预机制。方法:将40只雄性SD大鼠随机分为空白组、模型组、星状神经节埋线组、星状神经节阻滞组和布地奈德组,每... 目的:探讨星状神经节埋线通过血管活性肠肽(VIP)/环腺苷酸(cAMP)/cAMP直接激活的交换蛋白(Epac)信号通路对哮喘模型大鼠的干预机制。方法:将40只雄性SD大鼠随机分为空白组、模型组、星状神经节埋线组、星状神经节阻滞组和布地奈德组,每组8只。除空白组外,其余4组大鼠采用卵清蛋白(OVA)和氢氧化铝佐剂致敏结合OVA雾化激发的方法建立哮喘大鼠模型。自入组日起,造模大鼠于实验第0日、第7日,每只大鼠腹腔注射10% OVA混悬液1 mL以致敏,第15日起连续7 d每日雾化吸入5% OVA生理盐水溶液进行哮喘激发,所有大鼠均造模成功。实验第15日,星状神经节埋线组大鼠予C7椎体横突处穴位埋线;星状神经节阻滞组大鼠予星状神经节(C7椎体横突处)罗哌卡因注射,每日1次,连续7 d;布地奈德组大鼠予布地奈德雾化,每日1次,连续7 d。末次给药24 h后,麻醉大鼠取材进行指标检测。采用苏木精-伊红(HE)染色法观察各组大鼠肺组织病理变化,酶联免疫吸附(ELISA)法检测各组大鼠血清和肺泡灌洗液中白细胞介素5(IL-5)以及肺组织匀浆和血清中cAMP水平,蛋白质印迹法(Western blot法)检测各组大鼠肺组织VIP、Epac表达水平。结果:HE染色结果显示,模型组大鼠局部肺泡塌陷或间隔显著增厚,支气管周围可见大量炎性细胞浸润;各治疗组大鼠肺泡结构、支气管周围炎性细胞浸润均有明显改善,其中布地奈德组和星状神经节埋线组大鼠肺泡结构较完整,支气管周围炎性细胞浸润情况改善明显。模型组大鼠血清和肺泡灌洗液IL-5水平均明显高于空白组(P<0.01),血清和肺组织匀浆cAMP水平、肺组织VIP及Epac蛋白相对表达量均明显低于空白组(P<0.01);各治疗组大鼠上述指标均较模型组有明显改善(P<0.05,P<0.01);星状神经节埋线组大鼠上述指标与布地奈德组、星状神经节阻滞组比较,差异均无统计学意义(P>0.05)。结论:星状神经节埋线可显著改善哮喘模型大鼠气道炎症,减轻肺组织病理损伤,其机制可能与激活VIP/cAMP/Epac信号通路和降低炎性因子水平有关。 展开更多
关键词 哮喘 星状神经节 穴位埋线 vip/cAMP/Epac信号通路 白细胞介素5
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Rigorous verification of quantum contextuality from anomalous weak value
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作者 Wei-Qian Zhao Si-Nan Pang +3 位作者 Zi-Fu Su Tian-Ming Zhao Jin-Dong Wang Ya-Fei Yu 《Chinese Physics B》 2026年第2期306-313,共8页
Weak measurement offers a powerful framework for probing nonclassical features of quantum mechanics,with anomalous weak values serving as operational signatures of contextuality.While the anomalous weak value verifica... Weak measurement offers a powerful framework for probing nonclassical features of quantum mechanics,with anomalous weak values serving as operational signatures of contextuality.While the anomalous weak value verification of quantum contextuality has been predominantly investigated in the single-photon regime and analyzed under approximation condition of infinitesimally small perturbation strength.This study releases the approximation condition and takes into account the impact of perturbation strength on the rigor of the verification.And the investigation on the verification of contextuality is extended to the multi-photon scenarios for observing the influence of the correlation between photons on the verification.Without the limitation of infinitesimally small probability of disturbance,anomalous weak values are identified as necessary for contextuality to emerge,thereby refining the criterion proposed by Pusey[Phys.Rev.Lett.113200401(2014)].In the multi-photon scenarios,the emergence of contextuality also depends strongly on both the photon number and the photon-number distribution state.In particular,contextuality is found to be maximized when the single-photon component dominates and the second-order correlation is lower.These results highlight the critical role of photon statistics in experimental tests of contextuality via anomalous weak values. 展开更多
关键词 quantum measurement CONTEXTUALITY weak measurement weak values
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Diagnostic value of mismatch-negativity and P3a event-related potentials for sepsis-associated encephalopathy in non-sedated patients:a pilot study
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作者 Zengzheng Ge Xin Lu +7 位作者 Shiyuan Yu Mubing Qin Chao Gong Qun Xu Yanxia Gao Joseph Harold Walline Huadong Zhu Yi Li 《World Journal of Emergency Medicine》 2026年第2期172-178,共7页
BACKGROUND:Although the Confusion Assessment Methods for the Intensive Care Unit(CAMICU) is a recommended tool for diagnosing sepsis-associated encephalopathy(SAE),it has several limitations.Mismatch-negativity(MMN) a... BACKGROUND:Although the Confusion Assessment Methods for the Intensive Care Unit(CAMICU) is a recommended tool for diagnosing sepsis-associated encephalopathy(SAE),it has several limitations.Mismatch-negativity(MMN) and P3a are components of event-related potentials(ERPs) used with electroencephalography(EEG) and are associated with cerebral function changes in critically ill patients.This study aimed to provide a quantitative,non-invasive method to guide SAE diagnosis in nonsedated patients.METHODS:From January 2022 to March 2023,sepsis patients without sedation were enrolled and assessed via the CAM-ICU,Glasgow Coma Scale(GCS),and ERP under standard procedures.Both MMN and P3a data were collected.The diagnostic value of MMN and P3a was assessed with processed ERP data.RESULTS:Thirty-six patients were included in this study,comprising 19 patients with SAE and 17 patients without SAE(NSAE).MMN and P3a amplitudes decreased,and only FzMMN amplitude significantly decreased in SAE patients(2.03 [1.08,2.93] mV vs.3.21 [1.92,4.34] mV,P=0.040).After median dichotomization,low F3P3a and FzP3a amplitudes were associated with higher CAM-ICU positivity rates and APACHE II scores.Both amplitude in F3P3a(AUC=0.710,95%CI:0.527–0.893,P=0.034) and FzP3a(AUC=0.700,95%CI:0.519–0.881,P=0.041) exhibited moderate diagnostic efficacy for SAE,while FzMMN amplitude lacks effective diagnostic value.CONCLUSION:In this pilot study,ERP components F3P3a and FzP3a amplitudes demonstrated moderate diagnostic value for SAE.These exploratory findings require confirmation in larger and powered cohorts. 展开更多
关键词 Sepsis-associated encephalopathy Event-related potentials Mismatch-negativity Electroencephalography Diagnostic value
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VIP真空绝热板企业积极应对成本挑战,助力冰箱行业节能升级
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作者 邓雅静 《电器》 2026年第3期42-42,共1页
GB 12021.2-2025《家用电冰箱耗电量限定值及能效等级》即将正式实施,具有极低导热系数的VIP真空绝热板或将迎来较大的市场机会,但现阶段依然面临成本较高的挑战。机会和挑战面前,VIP真空绝热板企业一方面通过技术创新降低产品成本,另... GB 12021.2-2025《家用电冰箱耗电量限定值及能效等级》即将正式实施,具有极低导热系数的VIP真空绝热板或将迎来较大的市场机会,但现阶段依然面临成本较高的挑战。机会和挑战面前,VIP真空绝热板企业一方面通过技术创新降低产品成本,另一方面拓展更多新业务领域,打造多元化赛道。 展开更多
关键词 节能升级 冰箱行业 vip真空绝热板 成本挑战
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Assessment of pan-immune-inflammation value as a novel marker of proliferative diabetic retinopathy stage
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作者 Ozlem Candan Gözde Orman +1 位作者 NurtenÜnlü Güner Uney 《International Journal of Ophthalmology(English edition)》 2026年第3期517-525,共9页
AIM:To evaluate the predictive value of pan-immuneinflammation value(PIV)in the diagnosis of proliferative diabetic retinopathy(PDR)and its association with the stage of PDR.METHODS:This observational case-control stu... AIM:To evaluate the predictive value of pan-immuneinflammation value(PIV)in the diagnosis of proliferative diabetic retinopathy(PDR)and its association with the stage of PDR.METHODS:This observational case-control study included participants who underwent routine complete blood count testing.Inflammation-related indices,including neutrophil-to-lymphocyte ratio,systemic immune-inflammation index(SII),and PIV,were derived and analyzed.Receiver operating characteristic curve(ROC)analysis was applied to assess the diagnostic performance of these indices in distinguishing patients with PDR,with sensitivity,specificity,area under ROC,and optimal threshold values calculated.In addition,binary logistic regression analysis was performed to evaluate the association between inflammatory indices and PDR stage.RESULTS:This study included 205 patients:60 with diabetes without retinopathy(mean age:61.81±10.76y),80 with PDR(mean age:61.63±10.03y)and 65 healthy controls(mean age:59.52±5.88y).The PDR group had significantly higher white blood cell(WBC,P<0.001),monocyte(MONO,P=0.009)and neutrophil(NEU)counts(P<0.001).SII and PIV had the highest sensitivity and area under ROC for predicting patients with PDR(0.822,0.846,respectively).The optimal cut-off values for discriminating patients with PDR were determined to be>527.12 and>299.08 for SII and PIV,respectively.The logistic regression analysis demonstrated that a decrease in lymphocyte(LYM)count and an increase in platelet count(PLT),glycated haemoglobin(HbA1c),SII,and PIV were all significantly associated with the development of high-risk PDR(all P<0.05).PIV was more stable than independent MONO,LYM,PLT and NEU levels in predicting both the diagnosis and stage of PDR.The optimal cut-off value for PIV to discriminate patients with high-risk PDR was found to be>345.87 area under ROC=0.871,with sensitivity of 0.827 and specificity of 0.812.CONCLUSION:PIV is a reliable,valuable,and inexpensive blood index that can be used for early detection and staging of PDR.PIV may therefore be essential to be used for the follow-up of diabetic patients. 展开更多
关键词 pan-immune-inflammation value proliferative diabetic retinopathy systemic immuneinflammation index monocyte-related inflammation systemic inflammation
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NONLINEAR RIEMANN AND HILBERT BOUNDARY VALUE PROBLEMS WITH SQUARE ROOTS IN VARIABLE EXPONENT SPACES
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作者 Yajun Hu Fuli He 《Acta Mathematica Scientia》 2026年第1期1-18,共18页
In this paper,we study the nonlinear Riemann boundary value problem with square roots that is represented by a Cauchy-type integral with kernel density in variable exponent Lebesgue spaces.We discuss the odd-order zer... In this paper,we study the nonlinear Riemann boundary value problem with square roots that is represented by a Cauchy-type integral with kernel density in variable exponent Lebesgue spaces.We discuss the odd-order zero-points distribution of the solutions and separate the single valued analytic branch of the solutions with square roots,then convert the problem to a Riemann boundary value problem in variable exponent Lebesgue spaces and discuss the singularity of solutions at individual zeros belonging to curve.We consider two types of cases those where the coefficient is Hölder and those where it is piecewise Hölder.Then we solve the Hilbert boundary value problem with square roots in variable exponent Lebesgue spaces.By discussing the distribution of the odd-order zero-points for solutions and the method of symmetric extension,we convert the Hilbert problem to a Riemann boundary value problem.The equivalence of the transformation is discussed.Finally,we get the solvable conditions and the direct expressions of the solutions in variable exponent Lebesgue spaces. 展开更多
关键词 boundary value problem Cauchy-type integral variable exponent spaces non-linearity piecewise Lyapunov curve
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Social Network and Value Chain Integration:Unraveling the Formation and Evolution of Meizhou Pomelo Industry Cluster in China
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作者 YANG Ren LIN Yuancheng ZHANG Xin 《Chinese Geographical Science》 2026年第2期239-255,共17页
The shift toward specialized and large-scale agricultural production has spurred the emergence of agricultural clusters as key forces of rural vitalization and sustainable development.This paper explored the formation... The shift toward specialized and large-scale agricultural production has spurred the emergence of agricultural clusters as key forces of rural vitalization and sustainable development.This paper explored the formation and evolution of Meizhou pomelo industry cluster in China,focusing on its role in restructuring rural socio-economic systems and integrating the whole value chains.Based on a case study employing qualitative methods such as in-depth interviews and participatory observation,the agricultural cluster evolution of Meizhou pomelo was categorized into three key phases of initial decentralization,self-organized scaling,and reorganized clustering.Geographical proximity and industrial agglomeration constitute the physical foundation,while vertical/horizontal linkages,technologic-al innovation,and policy support enhance competitiveness.Special mechanisms emerge through localized social networks,farmer co-operatives’activation,and cross-regional market expansion.The cluster’s impact is manifested in the shift from extensive to standard-ized and modernized production,diversified and flexible livelihood of farmers,and the integration of agriculture with industry and ser-vices.The development of the whole value chain based on agricultural cluster represents a critical pathway for achieving agricultural modernization,encompassing both internal and external value chain optimization.Through quality assurance systems,product diversi-fication strategies,operational efficiency improvements,and brand enhancement,these clusters amplify product value propositions and market competitiveness.This systemic approach facilitates supply-demand coordination,enables resource synergies,and optimizes eco-nomic returns across the horizontal and vertical value chain.This paper argues that agricultural clusters serve as strategic catalysts for sustainable rural development by reconstructing local production systems,fostering innovation ecosystems,and aligning agricultural modernization.It contributes to debates on rural vitalization by demonstrating how agricultural clustering can reconfigure rural areas as hubs of ecological modernization,rather than mere urban peripheries. 展开更多
关键词 agricultural cluster sustainable rural development agricultural systems social network whole value chain China
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The five major textile and apparel industry clusters in Xinjiang have achieved an output value exceeding 220 billion yuan
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作者 Qiu Shuchen 《China Textile》 2026年第1期34-35,共2页
In the Tianshan region,a complete textile industry chain has been established,covering the entire process from cotton cultivation and chemical fiber production,through spinning,weaving,dyeing,and finishing,and further... In the Tianshan region,a complete textile industry chain has been established,covering the entire process from cotton cultivation and chemical fiber production,through spinning,weaving,dyeing,and finishing,and further extending to apparel,home textiles,and industrial textiles.In November 2025,the first list of five characteristic textile and apparel industry clusters in Xinjiang was officially announced,marking a new stage in the clustering of Xinjiang's textile and apparel industry.Data shows that the total output value of Xinjiang's cotton and textile and apparel industry chain has exceeded 220 billion yuan.With the nation's largest cotton production,a complete industrial chain system,and strong synergistic effects,Xinjiang has become a leading and highly competitive textile industry hub in China. 展开更多
关键词 clustering XINJIANG cotton production apparel industry chemical fiber industrial chain textile industry output value
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Pursuing Emotional Value
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《ChinAfrica》 2026年第3期60-61,共2页
The Double Take column looks at a single topic from an African and Chinese perspective.This month,we discuss how to understand the growing emphasis on emotional returns among young people.Emotional value has emerged a... The Double Take column looks at a single topic from an African and Chinese perspective.This month,we discuss how to understand the growing emphasis on emotional returns among young people.Emotional value has emerged as a central force shaping youth decision-making across work,consumption,relationships and lifestyle choices.Unlike traditional economic rationality that prioritises income and material security,emotional value focuses on how choices make individuals feel and how they align with personal meaning.This shift is particularly evident in rapidly transforming societies such as China and Ghana,where economic restructuring,globalisation and social change have reshaped pathways to adulthood. 展开更多
关键词 youth decision making emotional returns emotional value material security INCOME WORK CONSUMPTION economic rationality
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A Study on the Form,Material,and Cultural Value of the Rosewood Four-Head Official’s Cap Chair With Golden Flecks:A Case Study of the Inscribed Piece by Wang Shixiang
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作者 HUANG Yun LIN Hai-tao 《Journal of Literature and Art Studies》 2026年第1期43-46,共4页
Ming-style furniture represents the pinnacle of Chinese traditional furniture,with the four-head official’s cap chair standing out as a representative category due to its classic form and cultural connotations.This p... Ming-style furniture represents the pinnacle of Chinese traditional furniture,with the four-head official’s cap chair standing out as a representative category due to its classic form and cultural connotations.This paper takes a specific rosewood four-head official’s cap chair inscribed by Wang Shixiang as the research subject,employing a tripartite approach of form analysis,material examination,and inscription interpretation.The chair strictly adheres to the classic form of Ming-style four-head official’s cap chairs,embodying the Ming Dynasty design philosophy of“the unity of function and aesthetics”.The scarcity and unique grain pattern of the golden-flecked rosewood(Zitan)endow it with the status of“gold among woods”.Wang Shixiang’s inscription binds the furniture to the cultural essence of“the charm of the Ming Dynasty”,transforming it into“heritable cultural heritage”.This paper provides a new perspective for the case study of Ming-style furniture and offers theoretical reference for the contemporary inheritance of traditional craftsmanship. 展开更多
关键词 Ming-style furniture Four-head official’s cap chair rosewood with golden flecks Wang Shixiang inscription cultural value
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Research on the Symbolic Value of Nuo Masks in the Context of Contemporary Intangible Cultural Heritage Preservation
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作者 LIU Yuan-feng HUANG Li-na LIN Hai-tao 《Journal of Literature and Art Studies》 2026年第1期67-71,共5页
The Nuo mask is the core visual vehicle within China’s Nuo culture and constitutes a complex symbolic system through facial features(icons),patterns(indexes),and colors(symbols).Within the context of intangible cultu... The Nuo mask is the core visual vehicle within China’s Nuo culture and constitutes a complex symbolic system through facial features(icons),patterns(indexes),and colors(symbols).Within the context of intangible cultural heritage(ICH)preservation,its value lies in the continuation and revitalization of its dynamic symbolic functions.Grounded in semiotic theory,this paper elaborates on three core dimensions of symbolic value manifested by Nuo masks in ICH preservation:a ritual symbol for living transmission,a symbol of identity for collective memory,and an aesthetic symbol as a source of creativity. 展开更多
关键词 Nuo masks intangible cultural heritage preservation symbolic value sense of community for the Chinese nation cultural innovation
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助阳通便汤治疗功能性便秘临床观察及对便秘模型小鼠结肠组织VIP的影响 被引量:2
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作者 王璐 隋楠 《中华中医药学刊》 北大核心 2025年第4期66-71,I0016,共7页
目的观察助阳通便汤对功能性便秘(脾肾阳虚证)患者的临床疗效和患者血清P物质(substance P,SP)、血管活性肠肽(vasoactive intestinal peptide,VIP)含量的影响,以及其对便秘模型小鼠结肠组织病理及VIP表达的影响。方法(1)将66例符合功... 目的观察助阳通便汤对功能性便秘(脾肾阳虚证)患者的临床疗效和患者血清P物质(substance P,SP)、血管活性肠肽(vasoactive intestinal peptide,VIP)含量的影响,以及其对便秘模型小鼠结肠组织病理及VIP表达的影响。方法(1)将66例符合功能性便秘诊断,且中医证型为脾肾阳虚证的患者,用随机数字表法进行分组,其中治疗组(33例)、对照组(33例),治疗组助阳通便汤130 mL日2次口服,对照组乳果糖15 mL日2次口服,均治疗2周。比较两组患者用药前后便秘症状评分、粪便性状评分、中医证候评分及血清SP、VIP含量。(2)将18只雄性BALB/c小鼠依据随机数字表法分为KB组(空白对照组)、MX组(模型组)、ZY组(助阳通便汤组)3组,每组6只,以复方地芬诺酯片混悬液80 mg/kg灌胃的方法进行造模。ZY组给予助阳通便汤0.2 mL/10 g连续2周灌胃,结束后取材,观察各组小鼠结肠组织病理及VIP免疫组化表达。结果(1)治疗后两组患者便秘症状及粪便性状的评分均比治疗前显著提高(P<0.05);治疗组中医证候评分差异有统计学意义(P<0.05);治疗组患者血清SP含量高于对照组(P<0.05),血清VIP含量低于对照组(P<0.05)。治疗组有效率90.0%,对照组有效率73.3%(P<0.05)。(2)与模型组(MX组)小鼠比较,助阳通便汤组(ZY组)小鼠结肠组织中VIP阳性表达细胞分布相对较密集,阳性细胞数量较多(P<0.05)。结论助阳通便汤对功能性便秘(脾肾阳虚证)患者的临床症状及中医证候有较好地改善,并且对患者血清SP、VIP含量有干预作用;助阳通便汤调控便秘模型小鼠结肠组织VIP含量是其治疗功能性便秘的作用机制之一。 展开更多
关键词 助阳通便汤 功能性便秘 脾肾阳虚型 SP vip
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肥胖型PCOS不孕症患者血清铁代谢指标、miR-29a、VIP的变化及临床意义
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作者 王屹雯 任宝红 +1 位作者 周亚红 温丽娜 《中南医学科学杂志》 2025年第3期418-421,共4页
目的探讨肥胖型多囊卵巢综合征(PCOS)不孕症患者血清铁代谢指标、miR-29a、血管活性肠肽(VIP)的变化及其临床意义。方法选取PCOS不孕症患者130例,按照是否肥胖分为肥胖组和非肥胖组;按照随访结果,肥胖组分为促排妊娠成功组和失败组,或... 目的探讨肥胖型多囊卵巢综合征(PCOS)不孕症患者血清铁代谢指标、miR-29a、血管活性肠肽(VIP)的变化及其临床意义。方法选取PCOS不孕症患者130例,按照是否肥胖分为肥胖组和非肥胖组;按照随访结果,肥胖组分为促排妊娠成功组和失败组,或者妊娠结局不良组和良好组。比较各组血清铁蛋白、miR-29a、VIP水平,采用ROC曲线分析铁蛋白、miR-29a及VIP的预测价值。结果肥胖组铁蛋白、miR-29a高于非肥胖组,VIP低于非肥胖组(P<0.05)。失败组铁蛋白、miR-29a高于成功组,VIP低于成功组(P<0.05)。不良组铁蛋白、miR-29a高于良好组,VIP低于良好组(P<0.05)。铁蛋白、miR-29a及VIP对促排妊娠失败具有良好的预测价值,铁蛋白、miR-29a对不良妊娠结局具有良好的预测价值(P<0.05)。结论PCOS不孕症患者血清铁蛋白、miR-29a升高,VIP降低,且与促排妊娠、妊娠结局有明显关系。 展开更多
关键词 肥胖型PCOS 不孕症 铁蛋白 miR-29a vip 妊娠结局
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红景天苷通过VIP-cAMP通路对大鼠腮腺放射性损伤的改善作用及机制
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作者 张春英 阴广维 +4 位作者 陈红 尤鸣达 刘金凤 张亚昆 胡耀杰 《中国药房》 北大核心 2025年第22期2796-2801,共6页
目的探讨红景天苷对大鼠腮腺放射性损伤的改善作用及机制。方法将大鼠随机分为正常组、放射组、红景天苷低剂量(红景天苷-L,50 mg/kg)组、红景天苷高剂量(红景天苷-H,100 mg/kg)组、红景天苷-H+抑制剂(100 mg/kg红景天苷+0.1μmol/kg H-... 目的探讨红景天苷对大鼠腮腺放射性损伤的改善作用及机制。方法将大鼠随机分为正常组、放射组、红景天苷低剂量(红景天苷-L,50 mg/kg)组、红景天苷高剂量(红景天苷-H,100 mg/kg)组、红景天苷-H+抑制剂(100 mg/kg红景天苷+0.1μmol/kg H-89)组,每组10只。除正常组外,其余各组大鼠通过放射线照射构建腮腺放射性损伤模型。各组大鼠腹腔注射相应药物或生理盐水,每日1次,连续40 d。末次给药后,检测血清中活性氧(ROS)、环磷酸腺苷(cAMP)、超氧化物歧化酶(SOD)、淀粉酶水平,观察腮腺组织病理学变化,检测腮腺组织细胞凋亡率和其中B细胞淋巴瘤2(Bcl-2)及其相关X蛋白(Bax)表达情况,白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)mRNA表达水平,以及Ⅲ型胶原蛋白(ColⅢ)、血管活性肠肽(VIP)蛋白表达水平和cAMP依赖性蛋白激酶(PKA)磷酸化水平。结果与正常组比较,放射组大鼠ROS、淀粉酶水平,细胞凋亡率、Bax表达水平和IL-6、TNF-αmRNA表达水平以及ColⅢ蛋白表达水平均显著升高,cAMP、SOD水平,Bcl-2表达水平和VIP蛋白表达水平及PKA磷酸化水平均显著降低(P<0.05);与放射组比较,红景天苷-L组和红景天苷-H组大鼠上述指标均显著改善(P<0.05),且红景天苷-H组改善更明显(P<0.05);抑制剂H-89显著逆转了红景天苷-H组大鼠上述指标的变化(P<0.05)。结论红景天苷可有效改善大鼠的腮腺放射性损伤,其机制可能与激活VIP-cAMP通路有关。 展开更多
关键词 红景天苷 放射性损伤 腮腺 vip-cAMP通路
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How does urbanization evolve heterogeneously in urbanized,urbanizing,and rural areas of China?Insights from ecosystem service value 被引量:2
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作者 Yikun Zhang Yongsheng Wang 《Geography and Sustainability》 2025年第3期117-128,共12页
The rapid population and land urbanization not only promoted economic development but also affected the ecosystem service value(ESV).In the context of new-type urbanization and green development,it’s essential to inv... The rapid population and land urbanization not only promoted economic development but also affected the ecosystem service value(ESV).In the context of new-type urbanization and green development,it’s essential to investigate the impacts of urbanization on ESV in China.However,a comprehensive and dynamic framework to reveal the relationship between ESV and urbanization processes is lacking.This study adopted multi-source datasets to portray China’s urbanization process by integrating population,land,and economic urbanization,eval-uated the ESV changes of 10 categories by gross ecosystem product(GEP)methods,and explored ESV changes within different urbanization scales and speeds.The results showed rapid urbanization in the population,land,and economic dimensions in China,with a faster process of economic urbanization.The ESV also exhibited an increasing trend,with higher levels in the southeastern coastal regions and lower levels in the northwestern regions.Urbanization had positive impacts on ESV across various research units,but the ESV exhibited heteroge-neous changes across different urbanization scales,speeds,and their interactive effects.The response of ESV to dynamic urbanization processes was influenced by socio-economic,ecological,and policy factors;it is essential to combine targeted measures with general ecological product value realization methods in each unit to maximize social-economic-ecological benefits. 展开更多
关键词 URBANIZATION Urban-rural areas Ecosystem service value Social-economic-ecological benefits China
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Prognostic value of combined detection of alpha-fetoprotein,plasma prothrombin activity,and serum prealbumin in acute-on-chronic liver failure 被引量:2
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作者 Rui-Xian Duan Ling Liu +1 位作者 Yan Wang Wen-Ming Wu 《World Journal of Gastrointestinal Surgery》 2025年第2期97-104,共8页
BACKGROUND Acute-on-chronic liver failure(ACLF)is a liver disease based on chronic liver disease,which is significantly influenced by clinical treatment regimen and disease status,and despite the existence of multiple... BACKGROUND Acute-on-chronic liver failure(ACLF)is a liver disease based on chronic liver disease,which is significantly influenced by clinical treatment regimen and disease status,and despite the existence of multiple prognostic assessment indicators for ACLF,the overall sensitivity and accuracy are relatively low.AIM To investigate the prognostic value of the combined detection of alpha-fetoprotein(AFP),plasma prothrombin activity(PTA),and serum prealbumin(PA)in ACLF.METHODS This retrospective study included 87 patients with ACLF admitted from February 2021 to February 2023 and categorized them into the survival(n=47)and death(n=40)groups according to their clinical outcomes 3 months posttreatment.All the participants underwent AFP,PTA,and PA level measurements upon admission.Baseline data,as well as AFP,PTA,and PA levels,were comparatively analyzed.Pearson correlation coefficients were utilized to analyze the correlations of AFP,PTA,and PA with different survival outcomes in patients with ACLF.Receiver operating characteristic(ROC)curves and areas under the curves were used to evaluate the predictive value of AFP,PTA,and PA for ACLF prognosis.RESULTS AFP,PTA,and PA levels were markedly decreased in the death group than in the survival group(P<0.05).Pearson analysis indicated a positive association of the AFP,PTA,and PA levels with the survival of patients with ACLF(P<0.05).ROC curve analysis determined the sensitivity and specificity of the combined diagnosis at 91.24%and 100.00%,respectively,both of which were notably increased compared to the single-index diagnosis.The ROC of their combined diagnosis was 0.989,significantly surpassing 0.907,0.849,and 0.853 of AFP,PTA,and PA,respectively.No statistically significant variance was determined in the sensitivity and specificity of the combined diagnosis vs the single detection(P>0.05).CONCLUSION The combined detection of AFP,PTA,and PA levels demonstrates favorable diagnostic value for the short-term prognosis of patients with ACLF,featuring high sensitivity and specificity. 展开更多
关键词 ALPHA-FETOPROTEIN Prothrombin activity PREALBUMIN Acute-on-chronic liver failure Prognostic value
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VIPS参数优化制备高性能膜蒸馏膜及其高矿化度矿井水处理应用
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作者 李真 刘淑琴 +2 位作者 李井峰 蒋斌斌 卞伟 《煤炭科学技术》 北大核心 2025年第10期282-293,共12页
膜蒸馏技术凭借运行压力低、可高效利用低品位热源等独特优势,在高矿化度矿井水零排放处理工艺体系中占据重要地位,是构建经济高效处理流程的关键技术单元之一,但高能量抗污染的膜蒸馏膜的欠缺阻碍了其迈向工业化应用。使用蒸汽诱导相分... 膜蒸馏技术凭借运行压力低、可高效利用低品位热源等独特优势,在高矿化度矿井水零排放处理工艺体系中占据重要地位,是构建经济高效处理流程的关键技术单元之一,但高能量抗污染的膜蒸馏膜的欠缺阻碍了其迈向工业化应用。使用蒸汽诱导相分离(VIPS)技术取代传统液致相分离技术制备疏水微孔聚偏氟乙烯(PVDF)膜,并将其应用在膜蒸馏高矿化度矿井水处理技术中。通过对VIPS过程温度、湿度、暴露时间等参数的协同调控,实现对膜结构与性能的优化。利用扫描电镜、孔隙率测试、孔径分析仪等表征手段,监测了不同参数条件对膜结构的影响,通过响应面法综合分析多因素之间的协同作用,使用高盐模拟水与宁东矿区真实高矿化度矿井水测试了优化VIPS膜在膜蒸馏过程中的实际性能表现。结果表明:温度升高会加速VIPS过程的相分离速度,减少膜表面结节结构的形成并帮助膜形成更大的孔径与孔隙率,但过高的温度会对孔隙率的提升起到抑制作用;湿度的增加有利于提升VIPS过程中非溶剂的入侵速率,帮助增大孔径与孔隙率,提升膜通量,但过高的湿度反而会使得孔隙封闭;暴露时间主要决定相分离的进程,暴露时间过短相分离不充分,暴露时间过长会使孔隙坍缩,适宜的暴露时间帮助形成均匀且高性能的膜。参数之间还存在不同程度的相互作用,温度与暴露时间的协同作用最为显著,其次是温度与湿度,而湿度与时间之间的作用较弱。最终使用温度40℃、湿度70%、暴露时间15 min为优化参数制备了VIPS膜,并且使用直接接触膜蒸馏装置评估了其处理性能。测试发现膜的平均通量分别达到14.75 L/(m^(2)·h)和14.03 L/(m^(2)·h),截留率均在99.9%以上,并且在测试期间始终保持稳定。测试前后膜表面电镜图片显示其并未出现明显的污染物附着情况,接触角测量数据测试前后也稳定在110°左右,说明膜具有较好的抗润湿和污染能力,展现出了良好的性能。 展开更多
关键词 高矿化度矿井水 膜蒸馏 蒸汽诱导相分离 PVDF膜
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基于VIP-MIC-SBS变量筛选的火电厂烟气流量软测量研究
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作者 邹祥波 熊凯 +6 位作者 陈公达 刘泽明 陈创庭 卢志民 卢伟业 陈小玄 姚顺春 《广东电力》 北大核心 2025年第8期1-11,共11页
碳排放连续在线监测法作为一种高效、可溯源的方法,在我国碳计量领域中逐渐应用。然而,由于烟囱管道的大直径、复杂烟气流场,以及流量计检修维护、粉尘堵塞导致的监测数据中断与异常,烟气流量的准确监测成为一大挑战。为此,提出一种融... 碳排放连续在线监测法作为一种高效、可溯源的方法,在我国碳计量领域中逐渐应用。然而,由于烟囱管道的大直径、复杂烟气流场,以及流量计检修维护、粉尘堵塞导致的监测数据中断与异常,烟气流量的准确监测成为一大挑战。为此,提出一种融合变量投影重要性分析(variable importance in projection,VIP)、最大信息系数(maximal information coefficient,MIC)及后向搜索(sequential backward selection,SBS)算法的联合筛选方法,结合支持向量机(support vector machine,SVM)构建烟气流量软测量模型。基于某F级燃气-蒸汽联合循环发电机组,通过VIP值评估辅助变量显著性,并结合MIC和SBS算法,进行变量冗余消除与优化选择,从而提升模型的预测精度和泛化能力。实验结果显示:SVM的表现优于长短时间记忆网络模型,与反向传播神经网络相比具有较好的泛化能力;当辅助变量数量为12时,模型性能最佳,测试集的均方根误差和平均绝对百分比误差均较低,验证了变量筛选方法的有效性;在稳态和非稳态工况下,模型预测值的平均绝对百分比误差小于0.7%,并有一定的滤波作用。 展开更多
关键词 烟气流量 软测量技术 变量投影重要性分析 最大信息系数 后向搜索 支持向量机
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HMFM: A Method for Identifying High-Value Patents by Fusing Multiple Features 被引量:2
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作者 Na Deng Jiuan Zhang 《Computers, Materials & Continua》 2025年第2期2235-2254,共20页
Rapid and accurate identification of high-quality patents can accelerate the transformation process of scientific and technological achievements, optimize the management of intellectual property rights and enhance the... Rapid and accurate identification of high-quality patents can accelerate the transformation process of scientific and technological achievements, optimize the management of intellectual property rights and enhance the vitality of innovation. Aiming at the shortcomings of the traditional high-value patent assessment method, which is relatively simple and seldom considers the influence of patentees, this paper proposes a high-quality patent method HMFM (High-Value Patent Multi-Feature Fusion Method) that fuses multi-dimensional features. A weighted node importance assessment method in complex network called GLE (Glob-Local-struEntropy) based on improved structural entropy is designed to calculate the influence of the patentee to form the patentee’s features, and the patent text features are extracted by BERT-DPCNN deep learning model, which is supplemented to the basic patent indicator system. Finally a machine learning algorithm is used to assess the value of patents. Experiment results show that our method can identify high-value patents more effectively and accurately. 展开更多
关键词 Patents high value assessment deep learning structural entropy complex networks BERT DPCNN
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Diagnostic value of endoscopic ultrasound in staging of pancreatic cancer 被引量:1
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作者 Xin Yang Nan Ge 《World Journal of Gastrointestinal Oncology》 2025年第7期148-155,共8页
Pancreatic cancer is recognized as one of the leading causes of cancer mortality,representing the second most common source of cancer-related deaths within the gastrointestinal domain.Surgical resection is currently t... Pancreatic cancer is recognized as one of the leading causes of cancer mortality,representing the second most common source of cancer-related deaths within the gastrointestinal domain.Surgical resection is currently the only definitive treatment;however,the subtle emergence of symptoms often leads to a diagnosis at an advanced stage,with merely 10%-15%of patients being eligible for surgical intervention.The primary obstacle to achieving a potential radical resection is the presence of distant metastatic disease or invasion of adjacent major vascular structures.This review aims to highlight the critical role of endoscopic ultrasound in the diagnosis and staging of pancreatic tumors.We systematically searched PubMed,MEDLINE and Web of Science by using‘pancreatic cancer’and‘endoscopic ultrasonography’as keywords.Relevant studies were reviewed and analyzed.Endoscopic ultrasonography(EUS)is efficient in the diagnosis and staging of pancreatic cancer,past studies reported the accuracy of EUS is 63%to 94%for T-staging and 44%to 82%for N-staging but there are still limitations that need to be comprehensively applied with other diagnostic methods to evaluation of distant metastasis for surgical resectability.Our review aims to reveal the value for the staging of pancreatic cancer. 展开更多
关键词 Endoscopic ultrasound Pancreatic cancer STAGING Diagnostic value
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