Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic sid...Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.展开更多
Objective:Mendelian randomization(MR)has been widely utilized for causal inference between diseases,and its implementation within the domain of traditional Chinese medicine(TCM)is considered feasible.Although previous...Objective:Mendelian randomization(MR)has been widely utilized for causal inference between diseases,and its implementation within the domain of traditional Chinese medicine(TCM)is considered feasible.Although previous clinical and epidemiological studies have demonstrated a close relationship between insomnia and depression,the inherent genetic factors underlying these associations are unclear.The aim of this study was to evaluate the causal relationship between depression and insomnia via bidirectional 2-sample MR and increase the understanding of the TCM theory of treating different diseases with the same method,particularly in the context of comorbid depression and insomnia.Methods:Genetic data related to depression and insomnia were extracted from published genome-wide association studies(GWAS)data sets.Single-nucleotide polymorphisms(SNPs)associated with depression and insomnia were used as instrumental variables to construct an“SNP-exposure-outcome”model.Bidirectional 2-sample MR analysis was conducted via inverse-variance weighted(IVW),weighted median,MR Egger regression,simple mode,and weighted mode methods.Furthermore,heterogeneity tests,pleiotropy analyses,and sensitivity analyses were performed.Results:The MR results revealed a causal relationship between depression and an increased risk of developing insomnia(IVW,OR=1.400,95%CI:1.246–1.573,P<0.001),and a causal relationship between insomnia and an increased risk of developing depression(IVW,OR=1.204,95%CI:1.144–1.266,P<0.001).Conclusions:There is a bidirectional causal relationship between depression and insomnia.These findings provide new theoretical support for the TCM approach of treating different diseases with the same method in the prevention and treatment of depression and insomnia and provide a scientific basis for the modernization of TCM.展开更多
Microbial-induced carbonate precipitation(MICP)has emerged as a promising eco-friendly and cost-effective alternative for improving the strength and stability of low-cohesion soils.This review provides an in-depth ana...Microbial-induced carbonate precipitation(MICP)has emerged as a promising eco-friendly and cost-effective alternative for improving the strength and stability of low-cohesion soils.This review provides an in-depth analysis of the microscopic mechanisms,implementation methods,and macroscopic properties of MICP in soil enhancement.The biogeochemical processes underlying MICP,including urea hydrolysis,denitrification,sulfate reduction,photosynthesis,and iron reduction,are discussed in detail.Various MICP implementation methods,such as two-phase treatment,one-phase treatment,and ex-situ mixing,are reviewed,highlighting their respective advantages and limitations in reinforcing low-cohesion soils.The review also addresses the performance of MICP-treated soils,including improvements in strength,stiffness,permeability,and durability.Furthermore,the key challenges and future prospects for microbial soil reinforcement technologies are summarized.Future research should focus on optimizing nutrient supply,enhancing bacterial retention and activity,controlling the crystallization process,conducting pilot projects,and reducing treatment costs.These efforts are crucial for advancing the practical application of MICP in sustainable infrastructure construction.This review aims to advance the understanding of MICP and its potential for sustainable soil improvement,offering valuable insights for geotechnical engineers.展开更多
Objective: To analyze the possible mechanism of the Huoluo Xiaoling Pill in the treatment of three diseases, hyperglycemia, hyperlipidemia, and metabolic syndrome, and to provide ideas for learning the mechanism of “...Objective: To analyze the possible mechanism of the Huoluo Xiaoling Pill in the treatment of three diseases, hyperglycemia, hyperlipidemia, and metabolic syndrome, and to provide ideas for learning the mechanism of “Treating different diseases with the same method” in Traditional Chinese Medicine(TCM) theory. Materials and Methods: The Traditional Chinese Medicine System Pharmacology Database and Uni Prot databases were used to screen the main ingredients and targets of the Huoluo Xiaoling Pill. The Gene Cards database was used to screen the targets of the diseases, and Cytoscape 3.7.2 was used to construct a “Drug-Components-Targets-Disease” network to determine the core components. The STRING database was used to construct the protein-protein-interaction network, and gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomics enrichment analyses were carried out on the Metascape database. Auto Dock 1.5.6 was used for molecular docking. Results: A total of 118 active components and 208 targets were screened in the Huoluo Xiaoling Pill. Quercetin, tanshinone IIA, luteolin, and ellagic acid were potential core components of Huoluo Xiaoling Pill treating the three diseases, and interleukin 6, Tumor necrosis factor, and vascular endothelial growth factor were potential key targets. Co-occurring GO biological processes involved responses to the molecules of bacterial origin, and the AGE-RAGE signaling, fluid shear stress, and atherosclerosis pathways were the co-occurring pathways. Molecular docking revealed good docking conditions between screened targets and components. Conclusion: This study predicted the mechanism of the Huoluo Xiaoling Pill in treating the three diseases. At the same time, the co-occurring targets and pathways between the three diseases provided a material basis for the TCM theory, “Treating different diseases with the same method.”展开更多
文摘Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.
基金supported by the China Academy of ChineseMedical Science(CACMS)Innovation Fund(No.CI2021A00603)the National Natural Science Foundation of China(No.82074299).
文摘Objective:Mendelian randomization(MR)has been widely utilized for causal inference between diseases,and its implementation within the domain of traditional Chinese medicine(TCM)is considered feasible.Although previous clinical and epidemiological studies have demonstrated a close relationship between insomnia and depression,the inherent genetic factors underlying these associations are unclear.The aim of this study was to evaluate the causal relationship between depression and insomnia via bidirectional 2-sample MR and increase the understanding of the TCM theory of treating different diseases with the same method,particularly in the context of comorbid depression and insomnia.Methods:Genetic data related to depression and insomnia were extracted from published genome-wide association studies(GWAS)data sets.Single-nucleotide polymorphisms(SNPs)associated with depression and insomnia were used as instrumental variables to construct an“SNP-exposure-outcome”model.Bidirectional 2-sample MR analysis was conducted via inverse-variance weighted(IVW),weighted median,MR Egger regression,simple mode,and weighted mode methods.Furthermore,heterogeneity tests,pleiotropy analyses,and sensitivity analyses were performed.Results:The MR results revealed a causal relationship between depression and an increased risk of developing insomnia(IVW,OR=1.400,95%CI:1.246–1.573,P<0.001),and a causal relationship between insomnia and an increased risk of developing depression(IVW,OR=1.204,95%CI:1.144–1.266,P<0.001).Conclusions:There is a bidirectional causal relationship between depression and insomnia.These findings provide new theoretical support for the TCM approach of treating different diseases with the same method in the prevention and treatment of depression and insomnia and provide a scientific basis for the modernization of TCM.
基金supported by the National Key Science and Technol-ogy Projects in Transportation Industry(Grant number 2021-MS5-127)the Research Program of the Hubei Department of Transportation(Grant number 2020-186-1-3).
文摘Microbial-induced carbonate precipitation(MICP)has emerged as a promising eco-friendly and cost-effective alternative for improving the strength and stability of low-cohesion soils.This review provides an in-depth analysis of the microscopic mechanisms,implementation methods,and macroscopic properties of MICP in soil enhancement.The biogeochemical processes underlying MICP,including urea hydrolysis,denitrification,sulfate reduction,photosynthesis,and iron reduction,are discussed in detail.Various MICP implementation methods,such as two-phase treatment,one-phase treatment,and ex-situ mixing,are reviewed,highlighting their respective advantages and limitations in reinforcing low-cohesion soils.The review also addresses the performance of MICP-treated soils,including improvements in strength,stiffness,permeability,and durability.Furthermore,the key challenges and future prospects for microbial soil reinforcement technologies are summarized.Future research should focus on optimizing nutrient supply,enhancing bacterial retention and activity,controlling the crystallization process,conducting pilot projects,and reducing treatment costs.These efforts are crucial for advancing the practical application of MICP in sustainable infrastructure construction.This review aims to advance the understanding of MICP and its potential for sustainable soil improvement,offering valuable insights for geotechnical engineers.
文摘Objective: To analyze the possible mechanism of the Huoluo Xiaoling Pill in the treatment of three diseases, hyperglycemia, hyperlipidemia, and metabolic syndrome, and to provide ideas for learning the mechanism of “Treating different diseases with the same method” in Traditional Chinese Medicine(TCM) theory. Materials and Methods: The Traditional Chinese Medicine System Pharmacology Database and Uni Prot databases were used to screen the main ingredients and targets of the Huoluo Xiaoling Pill. The Gene Cards database was used to screen the targets of the diseases, and Cytoscape 3.7.2 was used to construct a “Drug-Components-Targets-Disease” network to determine the core components. The STRING database was used to construct the protein-protein-interaction network, and gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomics enrichment analyses were carried out on the Metascape database. Auto Dock 1.5.6 was used for molecular docking. Results: A total of 118 active components and 208 targets were screened in the Huoluo Xiaoling Pill. Quercetin, tanshinone IIA, luteolin, and ellagic acid were potential core components of Huoluo Xiaoling Pill treating the three diseases, and interleukin 6, Tumor necrosis factor, and vascular endothelial growth factor were potential key targets. Co-occurring GO biological processes involved responses to the molecules of bacterial origin, and the AGE-RAGE signaling, fluid shear stress, and atherosclerosis pathways were the co-occurring pathways. Molecular docking revealed good docking conditions between screened targets and components. Conclusion: This study predicted the mechanism of the Huoluo Xiaoling Pill in treating the three diseases. At the same time, the co-occurring targets and pathways between the three diseases provided a material basis for the TCM theory, “Treating different diseases with the same method.”
