Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system.In the chronic inflammation microenvironment,the metabolic activity...Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system.In the chronic inflammation microenvironment,the metabolic activity of tissue cells undergoes extensive changes,which interfere with the normal function of immune cells.Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs,such as the stomach,liver,and colorectum.This metabolic-immune imbalance also corresponds to traditional Chinese medicine(TCM)theories of“yin-yang disharmony”and“disharmony between Ying-nutrients and Wei-defense.”The metabolic-immune imbalance has also been regarded as the key factor supporting“treatment of different diseases with the same method”,in which the same approach is adopted in the treatment of different conditions.In the TCM treatment process,it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function,thereby blocking the progression from inflammation to malignancy.Our study findings deepen the TCM understanding of metabolic-immune dysregulation and the relationship between metabolic-immune dysregulation,pattern identification,and treatment method.They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of“treating different diseases with the same method”.展开更多
Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic sid...Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.展开更多
Professor SHAO Jing-ming has obtained more significant effect during the clinical practice in treatment of wheezing diseases by adopting ＂three-acupoint and five-needling method＂ created by himself, and the effect h...Professor SHAO Jing-ming has obtained more significant effect during the clinical practice in treatment of wheezing diseases by adopting ＂three-acupoint and five-needling method＂ created by himself, and the effect has been widely recognized by doctors and patients. After decades of development, Shao＇s ＂three-acupoint and five-needling method＂ has become a therapy with complete theoretical system and a large number of clinical research achievements, and its application scope has been expanded. In this paper, the achievements of Shao＇s ＂three-acupoint and five-needling method＂ during clinical studies in the early, middle and current development stages and related problems were reviewed comprehensively.展开更多
Unsaturated loess in natural sites loses stability as the overburden load continuously increases.Traditional soil modifiers such as cement and fly ash affect the surrounding environment.A new type of material,i.e.,lig...Unsaturated loess in natural sites loses stability as the overburden load continuously increases.Traditional soil modifiers such as cement and fly ash affect the surrounding environment.A new type of material,i.e.,lignin,is environmentally friendly and able to increase the strength of loess.However,the engineering characteristics of the improved loess under unsaturated conditions are not yet clear.In this study,the soil-water characteristic curves(SWCCs)of lignin-improved loess samples were determined from 0 kPa to 700 kPa using a pressure plate instrument,and then,they were fitted using the van Genuchten(VG)model and the Fredlund and Xing(FX)model.In addition,the effects of the lignin content and sample preparation methods on the SWCCs were investigated to determine the optimal lignin content and a suitable sample preparation method for loess foundations.As the lignin content increases,the matric suction and residual water content of the improved loess increase.The suction stress increases with the increasing lignin contents of 1%–2%.At lignin contents of 3%–4%,the suction stress begins to decrease and the samples prepared using the slurry method has a lower suction stress than that prepared using the wet mixing method.The air entry value(AEV)increases with increasing lignin content.In addition,scanning electron microscopy(SEM)was used to investigate the microstructural variations.It was found that after the addition of lignin,the entrapment of the loess particles by the lignin fibers created some larger particles and smaller pore diameters,which in turn led to poor connectivity of the loess pores.These changes cause the matric suction of the modified loess to increase.展开更多
Ballast water has been a topic of concern for some time because of its potential to introduce invasive species to new habitats. To comply with the International Convention for the Control and Management of Ships' ...Ballast water has been a topic of concern for some time because of its potential to introduce invasive species to new habitats. To comply with the International Convention for the Control and Management of Ships' Ballast Water and Sediments, members of the International Maritime Organization(IMO) must equip their ships with on-board treatment systems to eliminate organism release with ballast water. There are many challenges associated with the implementation of this IMO guideline, one of which is the selection of species for testing the ecological impacts of the treated ballast water. In the United States, ballast water toxicity test methods have been defined by the United States Environmental Protection Agency. However, the test methods had not been finalized in China until the toxicity test methods for ballast water were established in 2008. The Chinese methods have been based on species from three trophic levels: Skeletonema costatum, Neomysis awatschensis, and Ctenogobius gymnauchen. All three species live in broad estuarine and open sea areas of China; they are sensitive to reference toxicants and acclimatize easily to different conditions. In this paper, the biological characteristics, test processes and statistical analysis methods are presented for the three species. Results indicate that the methods for evaluating these three organisms can be included in the ecological toxicity tests for treated ballast water in China.展开更多
基金supported by National Natural Science Foundation of China(92059102 and 81630080)the National Key Research and Development Plan of China(2018YFC1704106).
文摘Inflammation-mediated carcinogenesis develops in the context of chronic inflammation and is a significant cause of cancer within the digestive system.In the chronic inflammation microenvironment,the metabolic activity of tissue cells undergoes extensive changes,which interfere with the normal function of immune cells.Dysregulation of cell metabolism and immune function has been identified as a key factor contributing to inflammation-mediated carcinogenesis within the major digestive organs,such as the stomach,liver,and colorectum.This metabolic-immune imbalance also corresponds to traditional Chinese medicine(TCM)theories of“yin-yang disharmony”and“disharmony between Ying-nutrients and Wei-defense.”The metabolic-immune imbalance has also been regarded as the key factor supporting“treatment of different diseases with the same method”,in which the same approach is adopted in the treatment of different conditions.In the TCM treatment process,it is necessary to first identify TCM patterns and then apply the corresponding TCM to correct the dysregulated metabolic and immune function,thereby blocking the progression from inflammation to malignancy.Our study findings deepen the TCM understanding of metabolic-immune dysregulation and the relationship between metabolic-immune dysregulation,pattern identification,and treatment method.They also provide new insights for the treatment of inflammation-mediated carcinogenesis in major digestive organs and help us further explore the scientific connotation of the TCM strategy of“treating different diseases with the same method”.
文摘Triple-negative breast cancer(TNBC)is marked by its high degree of malignancy and challenging treatment outcomes.While Western medicine predominantly relies on chemotherapy,issues such as drug resistance and toxic side effects remain prevalent.Drawing on the traditional Chinese medicine(TCM)principle of“treating the same disease with different methods,”Bian devises individualized therapeutic strategies tailored to the unique syndrome patterns of TNBC patients,adhering to the core tenets of“treatment based on syndrome differentiation”and“simultaneous regulation of the liver and spleen.”Through an analysis of clinical cases involving TNBC patients,this paper summarizes Bian’s clinical experience,which emphasizes foundational approaches such as strengthening the body’s resistance and soothing the liver to regulate qi,combined with personalized therapies including clearing heat and draining dampness,pacifying the liver and subduing yang,and resolving phlegm to unblock collaterals.The study highlights a diagnostic model of“multiple prescriptions for one disease,tailored to individual conditions,”providing valuable insights for the personalized TCM treatment of TNBC.
基金Supported by The Workstation of Affiliated Hospital of Gansu University of Chinese Medicine,Henan Shao’s Acupuncture-Moxibustion School Studio:LP0116036-Z8
文摘Professor SHAO Jing-ming has obtained more significant effect during the clinical practice in treatment of wheezing diseases by adopting ＂three-acupoint and five-needling method＂ created by himself, and the effect has been widely recognized by doctors and patients. After decades of development, Shao＇s ＂three-acupoint and five-needling method＂ has become a therapy with complete theoretical system and a large number of clinical research achievements, and its application scope has been expanded. In this paper, the achievements of Shao＇s ＂three-acupoint and five-needling method＂ during clinical studies in the early, middle and current development stages and related problems were reviewed comprehensively.
基金funded by the Natural Science Foundation of the Inner Mongolia Autonomous Region(Grant No.2020BS04003)the Project of High-Level Talent Research in Inner Mongolia University(Grant No.12000-15031942)the National Natural Science Foundation of China(Grant No.51778590,51879131).
文摘Unsaturated loess in natural sites loses stability as the overburden load continuously increases.Traditional soil modifiers such as cement and fly ash affect the surrounding environment.A new type of material,i.e.,lignin,is environmentally friendly and able to increase the strength of loess.However,the engineering characteristics of the improved loess under unsaturated conditions are not yet clear.In this study,the soil-water characteristic curves(SWCCs)of lignin-improved loess samples were determined from 0 kPa to 700 kPa using a pressure plate instrument,and then,they were fitted using the van Genuchten(VG)model and the Fredlund and Xing(FX)model.In addition,the effects of the lignin content and sample preparation methods on the SWCCs were investigated to determine the optimal lignin content and a suitable sample preparation method for loess foundations.As the lignin content increases,the matric suction and residual water content of the improved loess increase.The suction stress increases with the increasing lignin contents of 1%–2%.At lignin contents of 3%–4%,the suction stress begins to decrease and the samples prepared using the slurry method has a lower suction stress than that prepared using the wet mixing method.The air entry value(AEV)increases with increasing lignin content.In addition,scanning electron microscopy(SEM)was used to investigate the microstructural variations.It was found that after the addition of lignin,the entrapment of the loess particles by the lignin fibers created some larger particles and smaller pore diameters,which in turn led to poor connectivity of the loess pores.These changes cause the matric suction of the modified loess to increase.
基金Supported by the National Key Technology R&D Program of China(No.2006BAC11B05)
文摘Ballast water has been a topic of concern for some time because of its potential to introduce invasive species to new habitats. To comply with the International Convention for the Control and Management of Ships' Ballast Water and Sediments, members of the International Maritime Organization(IMO) must equip their ships with on-board treatment systems to eliminate organism release with ballast water. There are many challenges associated with the implementation of this IMO guideline, one of which is the selection of species for testing the ecological impacts of the treated ballast water. In the United States, ballast water toxicity test methods have been defined by the United States Environmental Protection Agency. However, the test methods had not been finalized in China until the toxicity test methods for ballast water were established in 2008. The Chinese methods have been based on species from three trophic levels: Skeletonema costatum, Neomysis awatschensis, and Ctenogobius gymnauchen. All three species live in broad estuarine and open sea areas of China; they are sensitive to reference toxicants and acclimatize easily to different conditions. In this paper, the biological characteristics, test processes and statistical analysis methods are presented for the three species. Results indicate that the methods for evaluating these three organisms can be included in the ecological toxicity tests for treated ballast water in China.
