Objective To determine the correlation between traditional Chinese medicine(TCM)inspec-tion of spirit classification and the severity grade of depression based on facial features,offer-ing insights for intelligent int...Objective To determine the correlation between traditional Chinese medicine(TCM)inspec-tion of spirit classification and the severity grade of depression based on facial features,offer-ing insights for intelligent intergrated TCM and western medicine diagnosis of depression.Methods Using the Audio-Visual Emotion Challenge and Workshop(AVEC 2014)public dataset on depression,which conclude 150 interview videos,the samples were classified ac-cording to the TCM inspection of spirit classification:Deshen(得神,presence of spirit),Shaoshen(少神,insufficiency of spirit),and Shenluan(神乱,confusion of spirit).Meanwhile,based on Beck Depression Inventory-II(BDI-II)score for the severity grade of depression,the samples were divided into minimal(0-13,Q1),mild(14-19,Q2),moderate(20-28,Q3),and severe(29-63,Q4).Sixty-eight landmarks were extracted with a ResNet-50 network,and the feature extracion mode was stadardized.Random forest and support vectior machine(SVM)classifiers were used to predict TCM inspection of spirit classification and the severity grade of depression,respectively.A Chi-square test and Apriori association rule mining were then applied to quantify and explore the relationships.Results The analysis revealed a statistically significant and moderately strong association be-tween TCM spirit classification and the severity grade of depression,as confirmed by a Chi-square test(χ^(2)=14.04,P=0.029)with a Cramer’s V effect size of 0.243.Further exploration us-ing association rule mining identified the most compelling rule:“moderate depression(Q3)→Shenluan”.This rule demonstrated a support level of 5%,indicating this specific co-occur-rence was present in 5%of the cohort.Crucially,it achieved a high Confidence of 86%,mean-ing that among patients diagnosed with Q3,86%exhibited the Shenluan pattern according to TCM assessment.The substantial Lift of 2.37 signifies that the observed likelihood of Shenlu-an manifesting in Q3 patients is 2.37 times higher than would be expected by chance if these states were independent-compelling evidence of a highly non-random association.Conse-quently,Shenluan emerges as a distinct and core TCM diagnostic manifestation strongly linked to Q3,forming a clinically significant phenotype within this patient subgroup.展开更多
Objective:To explore the diagnostic value of traditional Chinese medical(TCM)dialectical classification in Hashimoto's thyroiditis complicated with suspicious nodules.Methods:The clinical data of patients with Has...Objective:To explore the diagnostic value of traditional Chinese medical(TCM)dialectical classification in Hashimoto's thyroiditis complicated with suspicious nodules.Methods:The clinical data of patients with Hashimoto's thyroiditis complicated with thyroid nodules in the Department of Breast and thyroid surgery of Weifang Hospital of traditional Chinese Medicine from January 2018 to December 2019 were collected.The patients were examined by 2 or more experienced TCM doctors,and the four diagnostic data were obtained,and then the relevant syndrome types of the patients were judged according to the data.According to the color Doppler ultrasonographic features of thyroid nodules,the patients who met the indication of fine needle aspiration biopsy of thyroid nodules were selected and underwent fine needle aspiration biopsy of thyroid nodules before operation.To analyze the clinical diagnostic value of that the ultrasonic mode used in this study and thyroid cytopathology Bethesda report system combine dialectical classification of traditional Chinese medicine in Hashimoto's thyroiditis complicated with suspected thyroid nodules.Result:A total of 89 patients with Hashimoto's thyroiditis complicated with thyroid nodules were collected.according to the ultrasonic mode,the difference between different modes was statistically significant(P<0.05).The mode of color ultrasound is also related to the dialectical classification of traditional Chinese medicine.The patients with high malignant risk score are mainly qi depression and phlegm stagnation,phlegm and blood stasis,while those with low score are exuberant liver fire and heart liver yin deficiency.According to the study of different The Bethesda System for Reporting Thyroid Cytopathology(TBSRTC)classification,the dialectical classification of patients with higher TBSRTC classification was more inclined to qi depression and phlegm stagnation,phlegm and blood stasis,and there was significant difference between different classification(P<0.05).Conclusion:Qi depression and phlegm obstruction,phlegm and blood stasis have high ultrasound malignant risk score and high TBSRTC classification grade in patients with Hashimoto's thyroiditis complicated with suspected thyroid nodules,which has important clinical diagnostic value.展开更多
Differences between healthy subjects and associated disease risks are of substantial interest in clinical medicine. Based on clinical presentations, Traditional Chinese Medicine （TCM） classifies healthy people into ...Differences between healthy subjects and associated disease risks are of substantial interest in clinical medicine. Based on clinical presentations, Traditional Chinese Medicine （TCM） classifies healthy people into nine constitutions： Balanced, Qi, Yang or Yin deficiency, Phlegm-dampness, Damp-heat, Blood stasis, Qi stagnation, and Inherited special constitutions. In particular, Yang and Yin deficiency constitutions exhibit cold and heat aversion, respectively. However, the intrinsic molecular characteristics of unbal- anced phenotypes remain unclear. To determine whether gene expression-based clustering can reca- pitulate TCM-based classification, peripheral blood mononudear cells （PBMCs） were collected from Chinese Han individuals with Yang/Yin deficiency （n = 12 each） and Balanced （n = 8） constitutions, and global gene expression profiles were determined using the Affymetrix HC-UI33A Plus 2.0 array. Notably, we found that gene expression-based classifications reflected distinct TCM-based subtypes. Consistent with the clinical observation that subjects with Yang deficiency tend toward obesity, series-clustering analysis detected several key lipid metabolic genes （diacylglycerol acyltransferase （DGAT2）, acyl-CoA synthetase （ACSL1）, and ATP-hinding cassette subfamily A member 1 （ABCAI）） to be down- and up- regulated in Yin and Yang deficiency constitutions, respectively. Our findings suggest that Yin]Yang deficiency and Balanced constitutions are unique entities in their mRNA expression profiles. Moreover, the distinct physical and clinical characteristics of each unbalanced constitution can be explained, in part, by specific gene expression signatures.展开更多
基金Research and Development Plan of Key Areas of Hunan Science and Technology Department (2022SK2044)Clinical Research Center for Depressive Disorder in Hunan Province (2021SK4022)。
文摘Objective To determine the correlation between traditional Chinese medicine(TCM)inspec-tion of spirit classification and the severity grade of depression based on facial features,offer-ing insights for intelligent intergrated TCM and western medicine diagnosis of depression.Methods Using the Audio-Visual Emotion Challenge and Workshop(AVEC 2014)public dataset on depression,which conclude 150 interview videos,the samples were classified ac-cording to the TCM inspection of spirit classification:Deshen(得神,presence of spirit),Shaoshen(少神,insufficiency of spirit),and Shenluan(神乱,confusion of spirit).Meanwhile,based on Beck Depression Inventory-II(BDI-II)score for the severity grade of depression,the samples were divided into minimal(0-13,Q1),mild(14-19,Q2),moderate(20-28,Q3),and severe(29-63,Q4).Sixty-eight landmarks were extracted with a ResNet-50 network,and the feature extracion mode was stadardized.Random forest and support vectior machine(SVM)classifiers were used to predict TCM inspection of spirit classification and the severity grade of depression,respectively.A Chi-square test and Apriori association rule mining were then applied to quantify and explore the relationships.Results The analysis revealed a statistically significant and moderately strong association be-tween TCM spirit classification and the severity grade of depression,as confirmed by a Chi-square test(χ^(2)=14.04,P=0.029)with a Cramer’s V effect size of 0.243.Further exploration us-ing association rule mining identified the most compelling rule:“moderate depression(Q3)→Shenluan”.This rule demonstrated a support level of 5%,indicating this specific co-occur-rence was present in 5%of the cohort.Crucially,it achieved a high Confidence of 86%,mean-ing that among patients diagnosed with Q3,86%exhibited the Shenluan pattern according to TCM assessment.The substantial Lift of 2.37 signifies that the observed likelihood of Shenlu-an manifesting in Q3 patients is 2.37 times higher than would be expected by chance if these states were independent-compelling evidence of a highly non-random association.Conse-quently,Shenluan emerges as a distinct and core TCM diagnostic manifestation strongly linked to Q3,forming a clinically significant phenotype within this patient subgroup.
文摘Objective:To explore the diagnostic value of traditional Chinese medical(TCM)dialectical classification in Hashimoto's thyroiditis complicated with suspicious nodules.Methods:The clinical data of patients with Hashimoto's thyroiditis complicated with thyroid nodules in the Department of Breast and thyroid surgery of Weifang Hospital of traditional Chinese Medicine from January 2018 to December 2019 were collected.The patients were examined by 2 or more experienced TCM doctors,and the four diagnostic data were obtained,and then the relevant syndrome types of the patients were judged according to the data.According to the color Doppler ultrasonographic features of thyroid nodules,the patients who met the indication of fine needle aspiration biopsy of thyroid nodules were selected and underwent fine needle aspiration biopsy of thyroid nodules before operation.To analyze the clinical diagnostic value of that the ultrasonic mode used in this study and thyroid cytopathology Bethesda report system combine dialectical classification of traditional Chinese medicine in Hashimoto's thyroiditis complicated with suspected thyroid nodules.Result:A total of 89 patients with Hashimoto's thyroiditis complicated with thyroid nodules were collected.according to the ultrasonic mode,the difference between different modes was statistically significant(P<0.05).The mode of color ultrasound is also related to the dialectical classification of traditional Chinese medicine.The patients with high malignant risk score are mainly qi depression and phlegm stagnation,phlegm and blood stasis,while those with low score are exuberant liver fire and heart liver yin deficiency.According to the study of different The Bethesda System for Reporting Thyroid Cytopathology(TBSRTC)classification,the dialectical classification of patients with higher TBSRTC classification was more inclined to qi depression and phlegm stagnation,phlegm and blood stasis,and there was significant difference between different classification(P<0.05).Conclusion:Qi depression and phlegm obstruction,phlegm and blood stasis have high ultrasound malignant risk score and high TBSRTC classification grade in patients with Hashimoto's thyroiditis complicated with suspected thyroid nodules,which has important clinical diagnostic value.
基金supported by the National Key Basic Research Program of China (973 Program No. 2011CB505400)
文摘Differences between healthy subjects and associated disease risks are of substantial interest in clinical medicine. Based on clinical presentations, Traditional Chinese Medicine （TCM） classifies healthy people into nine constitutions： Balanced, Qi, Yang or Yin deficiency, Phlegm-dampness, Damp-heat, Blood stasis, Qi stagnation, and Inherited special constitutions. In particular, Yang and Yin deficiency constitutions exhibit cold and heat aversion, respectively. However, the intrinsic molecular characteristics of unbal- anced phenotypes remain unclear. To determine whether gene expression-based clustering can reca- pitulate TCM-based classification, peripheral blood mononudear cells （PBMCs） were collected from Chinese Han individuals with Yang/Yin deficiency （n = 12 each） and Balanced （n = 8） constitutions, and global gene expression profiles were determined using the Affymetrix HC-UI33A Plus 2.0 array. Notably, we found that gene expression-based classifications reflected distinct TCM-based subtypes. Consistent with the clinical observation that subjects with Yang deficiency tend toward obesity, series-clustering analysis detected several key lipid metabolic genes （diacylglycerol acyltransferase （DGAT2）, acyl-CoA synthetase （ACSL1）, and ATP-hinding cassette subfamily A member 1 （ABCAI）） to be down- and up- regulated in Yin and Yang deficiency constitutions, respectively. Our findings suggest that Yin]Yang deficiency and Balanced constitutions are unique entities in their mRNA expression profiles. Moreover, the distinct physical and clinical characteristics of each unbalanced constitution can be explained, in part, by specific gene expression signatures.
