The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process th...The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process that leads to a significant deterioration of non-uniformity when scaling up to larger areas.Since the performance of gaseous detectors is highly dependent on the choice of working gas,optimizing the gas mixture offers a promising solution to improve the uniformity performance.This paper addresses these challenges through a combined approach of simulation based on Garfield++and experimental studies.The simulation investigates the properties of different mixing fractions of gas mixtures and their impact on detector performance,including gain uniformity and time resolution.To verify the simulation results,experimental tests were conducted using a multi-channel PICOSEC MM prototype with different gas mixtures.The experimental results are consistent with the findings of the simulation,indicating that a higher concentration of neon significantly improves the detector’s gain uniformity.Furthermore,the influence of gas mixtures on time resolution was explored as a critical performance indicator.The study presented in this paper offers valuable insights for improving uniformity in large-area PICOSEC MM detectors and optimizing overall performance.展开更多
In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the s...In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the same hospitalization for patients with acute cholangitis(AC)associated with gallstones.Specifically,same-admission CCY is associated with significantly lower 30-day readmission rates compared with interval CCY.Furthermore,it has been associated with reduced mortality rates and reduced recurrence of biliary symptoms.Despite these advantages,the procedure is chosen in only a minority of eligible patients.This gap between evidence and practice highlights the need for updated clinical guidelines and further research to optimize the timing of CCY in the management of AC.展开更多
Over more than a decade of development,medium to deep shale gas reservoirs have faced rapid production declines,making sustained output challenging.To harness remaining reserves effectively,advanced fracturing techniq...Over more than a decade of development,medium to deep shale gas reservoirs have faced rapid production declines,making sustained output challenging.To harness remaining reserves effectively,advanced fracturing techniques such as infill drilling are essential.This study develops a complex fracture network model for dual horizontal wells and a four-dimensional in-situ stress evolution model,grounded in elastic porous media theory.These models simulate and analyze the evolution of formation pore pressure and in-situ stress during production.The investigation focuses on the influence of infill well fracturing timing on fracture propagation patterns,individual well productivity,and the overall productivity of well clusters.The findings reveal that,at infill well locations,the maximum horizontal principal stress undergoes the most significant reduction,while changes in the minimum horizontal principal stress and vertical stress remain minimal.The horizontal stress surrounding the infill well may reorient,potentially transitioning the stress regime from strike-slip to normal faulting.Delays in infill well fracturing increase lateral fracture deflection and diminish fracture propagation between wells.Considering the stable production phase and cumulative gas output of the well group,the study identifies an optimal timing for infill fracturing.Notably,larger well spacing shifts the optimal timing to a later stage.展开更多
Assisted hatching(AH)is commonly performed before trophectoderm(TE)biopsy for preimplantation genetic testing for aneuploidy(PGT-A),yet whether AH timing influences the detection of chromosomal mosaicism remains uncer...Assisted hatching(AH)is commonly performed before trophectoderm(TE)biopsy for preimplantation genetic testing for aneuploidy(PGT-A),yet whether AH timing influences the detection of chromosomal mosaicism remains uncertain.Beyond timing,procedural choices in PGT-A must balance diagnostic yield against potential harm from additional handling(e.g.,repeat TE biopsy or cryopreservation steps),as underscored by a recent systematic review and meta-analysis[1].展开更多
Anti-aliasing spectrum analysis is essential for rotor blade condition monitoring based on Blade Tip Timing(BTT).The Multiple Signal Classification(MUSIC)algorithm,which exploits the orthogonality between signal and n...Anti-aliasing spectrum analysis is essential for rotor blade condition monitoring based on Blade Tip Timing(BTT).The Multiple Signal Classification(MUSIC)algorithm,which exploits the orthogonality between signal and noise subspaces,has been successfully applied for this purpose.However,conventional subspace selection methods relying on fixed thresholds are sensitive to variations in large eigenvalues.Furthermore,the complex disturbances during rotor operation and measurement complicate the identification of blade vibration characteristics.To overcome these challenges,this paper proposes Adaptive Subspace Separation(ASS)and Local Spectral Centroid(LSC)methods to improve the adaptability of subspace selection and the stability of frequency identification,respectively.The impacts of overestimating and underestimating the subspace dimensions on MUSIC's performance are derived mathematically.Simulation and experiments demonstrate the effectiveness of proposed approaches:ASS offers more accurate and stable subspace dimension selection and tracking,while LSC reduces the standard deviation of estimated frequencies by 30 percent.展开更多
The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of ...The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of variability in the timing of seasonal sea ice retreat on the flux and composition of sinking particulate matter remains to be elucidated.In this study,we deployed sediment traps in Prydz Bay during the austral summers of 2019/2020 and 2020/2021,noting that sea ice melting occurred approximately one and a half months earlier in the former summer compared to the latter.We analyzed sediment trap data,which included total mass flux(TMF),particulate organic carbon(POC),biogenic silica(BSi),particulate inorganic carbon,and lithogenic particle(Litho)fluxes,as well as the stable isotopesδ^(13)C andδ^(15)N of particulate organic matter(POM).Additionally,we incorporated remote sensing data on sea ice concentration and chlorophyll a.This dramatic delay in sea ice melting timing could result in a significant increase in TMF,BSi and POC fluxes in the summer of 2020/2021 compared to 2019/2020.Elevated BSi fluxes and more ^(13)C-depleted POC in the austral summer of 2020/2021 suggest that the delayed melting of sea ice may have stimulated the productivity of centric diatoms.Furthermore,the higher BSi/POC ratio and more negativeδ^(15)N values of POM,along with a reduced presence of krill in the traps,indicate a diminished grazing pressure from zooplankton,which collectively enhanced the sedimentation efficiency of POC during the austral summer of 2020/2021.These findings highlight the critical role of sea ice melting timing in regulating productivity,flux and composition of sinking particulate matter in the Prydz Bay ecosystem,with significant implications for carbon cycling in polar oceans.展开更多
1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait ...1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait to celebrate at the finish line with his teenage son,who had raced ahead.Pham took another step or two,and that was the last thing he could remember.展开更多
Laser frequency microcombs provide a series of equidistant,coherent frequency markers across a broad spectrum,enabling advancements in laser spectroscopy,dense optical communications,precision distance metrology,and a...Laser frequency microcombs provide a series of equidistant,coherent frequency markers across a broad spectrum,enabling advancements in laser spectroscopy,dense optical communications,precision distance metrology,and astronomy.Here,we design and fabricate silicon nitride,dispersion-managed microresonators that effectively suppress avoided-mode crossings and achieve close-to-zero averaged dispersion.Both the stochastic noise and mode-locking dynamics of the resonator are numerically and experimentally investigated.First,we experimentally demonstrate thermally stabilized microcomb formation in the microresonator across different mode-locked states,showing negligible center frequency shifts and a broad frequency bandwidth.Next,we characterize the femtosecond timing jitter of the microcombs,supported by precise metrology of the timing phase and relative intensity noise.For the single-soliton state,we report a relative intensity noise of−153.2 dB∕Hz,close to the shot-noise limit,and a quantum-noise–limited timing jitter power spectral density of 0.4 as 2∕Hz at a 100 kHz offset frequency,measured using a self-heterodyne linear interferometer.In addition,we achieve an integrated timing jitter of 1.7 fs±0.07 fs,measured from 10 kHz to 1 MHz.Measuring and understanding these fundamental noise parameters in high clock rate frequency microcombs is critical for advancing soliton physics and enabling new applications in precision metrology.展开更多
BACKGROUND Bile duct leaks(BDLs)are serious postsurgical adverse events.Typically,conservative management with ab-dominal drainage is the initial treatment option.However,prolonged abdominal drainage without improveme...BACKGROUND Bile duct leaks(BDLs)are serious postsurgical adverse events.Typically,conservative management with ab-dominal drainage is the initial treatment option.However,prolonged abdominal drainage without improvement can lead to biliary stricture and delay the optimal timing of endoscopic retrograde cholangiopancreatography(ERCP).AIM To identify the optimal timing for ERCP and the period during which clinical observation with conservative management is acceptable,balancing ERCP success and the risk of biliary strictures.METHODS We conducted a multicenter retrospective study involving 448 patients with BDLs between November 2002 and November 2022.The patients were divided into four groups based on the timing of ERCP:3 days,7 days,14 days,and 21 days.The primary outcome was clinical success,defined as the resolution of BDL and related symptoms within 6 months without additional percutaneous drainage,surgery,or death.The secondary outcome was incidence of biliary strictures.Univariate and multivariate logistic regression analyses were performed to identify factors associated with ERCP success and biliary stricture occurrence.RESULTS In a cohort of 448 consecutive patients diagnosed with BDLs,354 were excluded,leaving 94 patients who underwent ERCP.Clinical success was achieved in 84%of cases(79/94),with a median ERCP timing of 20 days(9.5-35.3 days).Biliary strictures were identified in 29(30.9%)patients.Performing ERCP within 3 weeks,compared to after 3 weeks,was associated with higher success rates[92.0%(46/50)vs 75.0%(33/44),P=0.032]and a lower incidence of biliary stricture incidence[18.0%(9/50)vs 45.5%(20/44),P=0.005].Subsequent multivariate analysis confirmed the association with higher success rates(odds ratio=4.168,P=0.045)and lower biliary stricture rates(odds ratio=0.256,P=0.007).CONCLUSION Performing ERCP for BDLs within 3 weeks may be associated with a higher success rate and a lower biliary stricture rate.If patients with BDLs do not respond to conservative treatment,ERCP is suggested to be performed within 3 weeks.展开更多
Background:Rehabilitation typically restores shoulder function after a common rotator cuff repair;however,it is unclear when to initiate physical therapy(PT)post-surgery.To understand effective start times,this study ...Background:Rehabilitation typically restores shoulder function after a common rotator cuff repair;however,it is unclear when to initiate physical therapy(PT)post-surgery.To understand effective start times,this study analyzed PT start times and their effect on shoulder function.The most effective shoulder outcomes were hypothesized to occur when PT started 0-4 weeks post-surgery.Methods:Data from 1002 patients who underwent rotator cuff repair were analyzed retrospectively from 52 outpatient clinics in the years of 2016-2021.The primary data of timings between surgery and the start of PT(0-2 weeks[0-14 days],2-4 weeks[15-28 days],4-6 weeks[29-42 days],and 6-14 weeks[43-100 days]),change in functional shoulder scores,number of PT visits utilized,and functional scores changed per visit were analyzed.Regression analyses of the impact of age,sex,payor source,and tear size were completed.Results:The change in functional scores and functional scores changed per visit are not affected by the initiation timing of PT postrotator cuff surgery,when controlling for baseline functional scores.This result is revealed despite initial functional scores being significantly different.Functional scores change per visit may have been affected by payor source(R^(2)=0.004,p≤0.010).PT start times may have been impacted by age(R^(2)=0.010,p=0.007),payor source(R^(2)=0.016,p=0.001),and tear size(R^(2)=0.007,p=0.026).Payor source may have influenced the number of PT visits(R^(2)=0.060,p<0.001).Conclusions:After rotator cuff surgery,patients should choose to complete rehabilitation to optimize shoulder function.However,the initiation timing of PT may not affect functional shoulder outcomes.展开更多
AIM:To investigate the optimal timing and therapeutic effects of cataract surgery in patients with moderate to severe thyroid-associated ophthalmopathy(TAO).METHODS:Data from TAO patients who underwent cataract surger...AIM:To investigate the optimal timing and therapeutic effects of cataract surgery in patients with moderate to severe thyroid-associated ophthalmopathy(TAO).METHODS:Data from TAO patients who underwent cataract surgery between 2014 and 2024 were analyzed.patients were categorized into two groups based on the hospital where their cataract surgery was performed:an external hospital surgery group and an in-house hospital surgery group.Patients in external hospital presenting with complications within six months postoperatively were assessed for clinical features,imaging,thyroid function,and outcomes.Patients who underwent surgery at West China Hospital were evaluated for clinical status,imaging,laboratory findings,and manifestations.RESULTS:In the external hospital group(n=31),common symptoms included eyelid swelling(64.52%)and diplopia(51.61%),with restricted eye movement in all patients.Most patients were in the active stage(87.10%)and exhibited various complications,such as dysthyroid optic neuropathy(DON)in 4 patients,misdiagnosis of glaucoma in 1 patient,and enucleation due to fungal infection in 1 patient.In the West China Hospital group(n=30),2 patients were in the active stage,and 28 were in the inactive stage.Postoperative visual acuity improved in 36 eyes,except for in 2 eyes with DON.Active TAO patients with mature cataracts had effective inflammation control and no complications at the 6-month follow-up.CONCLUSION:In patients with moderate to severe active TAO complicated by cataracts,delaying cataract surgery until 6mo of TAO control should be considered if cataracts are stable.Simultaneous anti-inflammatory treatment and cataract surgery should be performed for mature/hypermature cataracts,and TAO management should be continued after surgery.展开更多
High-performance positioning,navigation and timing(PNT)service is critical to the safe flight of low-altitude aircraft and the effective management of low altitude traffic.In low-altitude economic sce-narios,the speci...High-performance positioning,navigation and timing(PNT)service is critical to the safe flight of low-altitude aircraft and the effective management of low altitude traffic.In low-altitude economic sce-narios,the specificity of massive unmanned aerial ve-hicle(UAV)flights and the complexity of low-altitude airspace traffic management impose stringent demand on the high-continuity,high-accuracy,real-time,and high-security PNT service.However,the current PNT service,which primarily relies on Global Navigation Satellite System(GNSS),Micro-Electro-Mechanical System Inertial Navigation System(MEMS INS),etc.,is completely inadequate to support the future needs of low-altitude economic development.In order to bridge the huge gap between existing capability and future demand,a three-layer PNT architecture based on the collaboration of space-based,air-based and ground-based PNT systems is proposed for low-altitude econ-omy.The space-based layer consists of high,medium even possible low orbit GNSS constellations,such as BeiDou Navigation Satellite System(BDS),for high-precision,high-security absolute positioning and tim-ing.The air-based layer leverages inter-aircraft links for high-reliability dynamic relative positioning.The ground-based layer includes pseudolite network,as well as 5G-advanced(5G-A)/6G network,for more comprehensive coverage and real-time positioning.To this end,it is imperative to make breakthroughs in key technologies,from systems to airborne terminal,in-cluding but not limited to high-precision anti-jamming GNSS signal processing,high-reliability relative po-sitioning,real-time pseudolite positioning,and high-efficient multi-source information fusion at airborne terminal,etc.Due to the moderate redundancy,hetero-geneous mechanism,and multiple coverage from mul-tiple PNT systems,the proposed layered PNT archi-tecture possesses high robustness and resilient.Addi-tionally,the integration of INS,LiDAR and vision etc.perception technologies can significantly enhance the PNT capability.As a result,the proposed three-layer PNT architecture enable greater autonomy for low-altitude aircraft and intelligent traffic management for massive UAV operations,and promoting the safe and efficient development of the low-altitude economy.展开更多
Polymer flooding has been proven to effectively improve oil recovery in the Bohai Oil Field. However, due to high oil viscosity and significant formation heterogeneity, it is necessary to further improve the displacem...Polymer flooding has been proven to effectively improve oil recovery in the Bohai Oil Field. However, due to high oil viscosity and significant formation heterogeneity, it is necessary to further improve the displacement effectiveness of polymer flooding in heavy oil reservoirs in the service life of offshore platforms. In this paper, the effects of the water/oil mobility ratio in heavy oil reservoirs and the dimensionless oil productivity index on polymer flooding effectiveness were studied utilizing rel- ative permeability curves. The results showed that when the water saturation was less than the value, where the water/oil mobility ratio was equal to 1, polymer flooding could effectively control the increase of fractional water flow, which meant that the upper limit of water/oil ratio suitable for polymer flooding should be the value when the water/oil mobility ratio was equal to 1. Mean while, by injecting a certain volume of water to create water channels in the reservoir, the polymer flooding would be the most effective in improving sweep efficiency, and lower the fractional flow of water to the value corresponding to △Jmax. Considering the service life of the platform and the polymer mobility control capacity, the best polymer injection timing for heavy oil reservoirs was optimized. It has been tested for reservoirs with crude oil viscosity of 123 and 70 mPa s, the optimum polymer flooding effec- tiveness could be obtained when the polymer floods were initiated at the time when the fractional flow of water were 10 % and 25 %, respectively. The injection timing range for polymer flooding was also theoretically analyzed for the Bohai Oil Field utilizing which provided methods for effectiveness. relative permeability curves, improving polymer flooding展开更多
To minimize the power consumption with resources operating at multiple voltages a time-constrained algorithm is presented.The input to the scheme is an unscheduled data flow graph (DFG),and timing or resource constrai...To minimize the power consumption with resources operating at multiple voltages a time-constrained algorithm is presented.The input to the scheme is an unscheduled data flow graph (DFG),and timing or resource constraints.Partitioning is considered with scheduling in the proposed algorithm as multiple voltage design can lead to an increase in interconnection complexity at layout level.That is,in the proposed algorithm power consumption is first reduced by the scheduling step,and then the partitioning step takes over to decrease the interconnection complexity.The time-constrained algorithm has time complexity of O(n 2),where n is the number of nodes in the DFG.Experiments with a number of DSP benchmarks show that the proposed algorithm achieves the power reduction under timing constraints by an average of 46 5%.展开更多
The pedestrian timing at signalized intersections is studied aiming at the problems of the inconsistency of the vehicular and pedestrian timing requirements and the insufficiency of pedestrian clearance. Based on the ...The pedestrian timing at signalized intersections is studied aiming at the problems of the inconsistency of the vehicular and pedestrian timing requirements and the insufficiency of pedestrian clearance. Based on the formulae of WALK and flashing DON＇T WALK （FDW） in the highway capacity manual （HCM）, the relationship between pedestrian signal indications and vehicular signal indications is discussed using the theory of traffic flow. Then, methods of pedestrian timing for different cases are established, particularly the methods of the pedestrian green adjustment. Ways of pedestrian crossing are analyzed for roadways with different forms and widths of the median island. The sampling values of calculation parameters are studied, and the recommended formulae of pedestrian timing for different conditions are presented.展开更多
In order to synchronize the elements of the EAST Neutral Beam Injector （NBI） spatially located in several places, a distributed Timing System （TS） is developed in this paper. The timing system provides a clock ref...In order to synchronize the elements of the EAST Neutral Beam Injector （NBI） spatially located in several places, a distributed Timing System （TS） is developed in this paper. The timing system provides a clock reference for synchronization and an interlock protection of the EAST NBI system. It sends timing signals to field devices, controls the pulse widths of the timing sequences, and provides a sampling clock for the Data Acquisition System （DAS）. The timing system also generates analog waveforms to control power supplies and gas supplies according to the operator＇s configuration. The timing system is developed on a PXI （PCI eXtensions for Instrumentation） platform consisting of a LabVIEW workstation and a timing control terminal. The timing control terminal consists of a timing node and several control interface crates. Two timing nodes are configured in one beam line. Each node is responsible for the timing sequence, analog generation and feedback control for one ion source. The architecture and implementation of the timing system are presented in this paper.展开更多
An algorithm of path based timing optimization by buffer insertion is presented.The algorithm adopts a high order model to estimate interconnect delay and a nonlinear delay model based on look up table for gate dela...An algorithm of path based timing optimization by buffer insertion is presented.The algorithm adopts a high order model to estimate interconnect delay and a nonlinear delay model based on look up table for gate delay estimation.And heuristic method of buffer insertion is presented to reduce delay.The algorithm is tested by industral circuit case.Experimental results show that the algorithm can optimize the timing of circuit efficiently and the timing constraint is satisfied.展开更多
A new approach of incremental placement approach is described.The obtained timing information drives an efficient net-based placement technique,which dynamically adapts the net weights during successive placement step...A new approach of incremental placement approach is described.The obtained timing information drives an efficient net-based placement technique,which dynamically adapts the net weights during successive placement steps.Several methods to combine timing optimization and congestion reducing together are proposed.Cells on critical paths are replaced according to timing and congestion constraints.Experimental results show that our approach can efficiently reduce cycle time and enhance route ability.The max path delay is reduced by 10% on an average afterincremental placement on wirelength-optimized circuits.And it achieves the same quality with a high speed up compared to timing driven detailed placement algorithm.展开更多
Timing speculative(TS)architecture is promising for improving the energy efficiency of microprocessors.Error recovery units,designed for tolerating occasional timing errors,have been used to support a wider range of v...Timing speculative(TS)architecture is promising for improving the energy efficiency of microprocessors.Error recovery units,designed for tolerating occasional timing errors,have been used to support a wider range of voltage scaling,therefore to achieve a better energy efficiency.More specifically,the timing error rate,influenced mainly by data forwarding,is the bottleneck for voltage down-scaling in TS processors.In this paper,a new Timing Error Aware Register Allocation method is proposed.First,we designed the Dependency aware Interference Graph(DIG)construction to get the information of Read after Write(RAW)in programs.To build the construction,we get the disassemble code as input and suppose that there are unlimited registers,the same way as so-called virtual registers in many compilers.Then we change the disassemble codes to the SSA form for each basic block to make sure the registers are defined only once.Based on the DIG construction,registers were real-located to eliminate the timing error,by loosening the RAW dependencies.We con-struct the DIG for each function of the program and sort the edge of DIG by an increasing weight order.Since a smaller weighted-edge value means that its owner nodes have more frequent access in instruction flows,we expect it in different registers with no read-write dependency.At the same time,we make sure that there are no additional new spill codes emerging in our algorithm to minimize the rate of spill code.A high rate of spill code will not only decrease the performance of the system but also increase the unexpected read-write dependency.Next,we reallocate the reg-isters by weight order in turn to loosen the RAW dependencies.Furthermore,we use the NOP operation to pad the instructions with a minimal distance value of 2.Experiment results showed that the average distance of RAW dependencies was increased by over 20%.展开更多
基金supported by the National Natural Science Foundation of China(12125505).
文摘The PICOSEC Micromegas(MM)is a precise timing gaseous detector based on a Cherenkov radiator coupled with a semi-transparent photocathode and an MM amplifying structure.It features a two-stage amplification process that leads to a significant deterioration of non-uniformity when scaling up to larger areas.Since the performance of gaseous detectors is highly dependent on the choice of working gas,optimizing the gas mixture offers a promising solution to improve the uniformity performance.This paper addresses these challenges through a combined approach of simulation based on Garfield++and experimental studies.The simulation investigates the properties of different mixing fractions of gas mixtures and their impact on detector performance,including gain uniformity and time resolution.To verify the simulation results,experimental tests were conducted using a multi-channel PICOSEC MM prototype with different gas mixtures.The experimental results are consistent with the findings of the simulation,indicating that a higher concentration of neon significantly improves the detector’s gain uniformity.Furthermore,the influence of gas mixtures on time resolution was explored as a critical performance indicator.The study presented in this paper offers valuable insights for improving uniformity in large-area PICOSEC MM detectors and optimizing overall performance.
文摘In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the same hospitalization for patients with acute cholangitis(AC)associated with gallstones.Specifically,same-admission CCY is associated with significantly lower 30-day readmission rates compared with interval CCY.Furthermore,it has been associated with reduced mortality rates and reduced recurrence of biliary symptoms.Despite these advantages,the procedure is chosen in only a minority of eligible patients.This gap between evidence and practice highlights the need for updated clinical guidelines and further research to optimize the timing of CCY in the management of AC.
基金supported by the National Natural Science Foundation of China(Grant No.52374043)the Southwest Oil&Gas Field Branch in PetroChina(Grant No.JS2023-115)。
文摘Over more than a decade of development,medium to deep shale gas reservoirs have faced rapid production declines,making sustained output challenging.To harness remaining reserves effectively,advanced fracturing techniques such as infill drilling are essential.This study develops a complex fracture network model for dual horizontal wells and a four-dimensional in-situ stress evolution model,grounded in elastic porous media theory.These models simulate and analyze the evolution of formation pore pressure and in-situ stress during production.The investigation focuses on the influence of infill well fracturing timing on fracture propagation patterns,individual well productivity,and the overall productivity of well clusters.The findings reveal that,at infill well locations,the maximum horizontal principal stress undergoes the most significant reduction,while changes in the minimum horizontal principal stress and vertical stress remain minimal.The horizontal stress surrounding the infill well may reorient,potentially transitioning the stress regime from strike-slip to normal faulting.Delays in infill well fracturing increase lateral fracture deflection and diminish fracture propagation between wells.Considering the stable production phase and cumulative gas output of the well group,the study identifies an optimal timing for infill fracturing.Notably,larger well spacing shifts the optimal timing to a later stage.
文摘Assisted hatching(AH)is commonly performed before trophectoderm(TE)biopsy for preimplantation genetic testing for aneuploidy(PGT-A),yet whether AH timing influences the detection of chromosomal mosaicism remains uncertain.Beyond timing,procedural choices in PGT-A must balance diagnostic yield against potential harm from additional handling(e.g.,repeat TE biopsy or cryopreservation steps),as underscored by a recent systematic review and meta-analysis[1].
基金supported by the National Natural Science Foundation of China(Nos.52405088 and 92360306)the Postdoctoral Fellowship Program of CPSF,China(No.GZC20241446)+2 种基金the Natural Science Basic Research Program of Shaanxi,China(No.2024JC-YBMS-402)the Fundamental Research Funds for the Central Universities,CHD(No.300102254102)the Foundation of Beilin District,China(No.GX2455)。
文摘Anti-aliasing spectrum analysis is essential for rotor blade condition monitoring based on Blade Tip Timing(BTT).The Multiple Signal Classification(MUSIC)algorithm,which exploits the orthogonality between signal and noise subspaces,has been successfully applied for this purpose.However,conventional subspace selection methods relying on fixed thresholds are sensitive to variations in large eigenvalues.Furthermore,the complex disturbances during rotor operation and measurement complicate the identification of blade vibration characteristics.To overcome these challenges,this paper proposes Adaptive Subspace Separation(ASS)and Local Spectral Centroid(LSC)methods to improve the adaptability of subspace selection and the stability of frequency identification,respectively.The impacts of overestimating and underestimating the subspace dimensions on MUSIC's performance are derived mathematically.Simulation and experiments demonstrate the effectiveness of proposed approaches:ASS offers more accurate and stable subspace dimension selection and tracking,while LSC reduces the standard deviation of estimated frequencies by 30 percent.
基金The National Key Research and Development Program of China under contract No.2022YFE0136500the Scientific Research Fund of the Second Institute of Oceanography,Ministry of Natural Resources,under contract Nos JG2212 and JG2211+2 种基金the National Natural Science Foundation of China under contract Nos 42276255,41976228,and 42176227the National Polar Special Program“Impact and Response of Antarctic Seas to Climate Change”under contract Nos IRASCC 01-01-02 and IRASCC 02-02the China Scholarship Council under contract No.201704180017.
文摘The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of variability in the timing of seasonal sea ice retreat on the flux and composition of sinking particulate matter remains to be elucidated.In this study,we deployed sediment traps in Prydz Bay during the austral summers of 2019/2020 and 2020/2021,noting that sea ice melting occurred approximately one and a half months earlier in the former summer compared to the latter.We analyzed sediment trap data,which included total mass flux(TMF),particulate organic carbon(POC),biogenic silica(BSi),particulate inorganic carbon,and lithogenic particle(Litho)fluxes,as well as the stable isotopesδ^(13)C andδ^(15)N of particulate organic matter(POM).Additionally,we incorporated remote sensing data on sea ice concentration and chlorophyll a.This dramatic delay in sea ice melting timing could result in a significant increase in TMF,BSi and POC fluxes in the summer of 2020/2021 compared to 2019/2020.Elevated BSi fluxes and more ^(13)C-depleted POC in the austral summer of 2020/2021 suggest that the delayed melting of sea ice may have stimulated the productivity of centric diatoms.Furthermore,the higher BSi/POC ratio and more negativeδ^(15)N values of POM,along with a reduced presence of krill in the traps,indicate a diminished grazing pressure from zooplankton,which collectively enhanced the sedimentation efficiency of POC during the austral summer of 2020/2021.These findings highlight the critical role of sea ice melting timing in regulating productivity,flux and composition of sinking particulate matter in the Prydz Bay ecosystem,with significant implications for carbon cycling in polar oceans.
文摘1 Tuan Pham was feeling pretty good about himself as he approached the 12-mile mark of the Long Beach Half Marathon in Southern California.The run was the 47-year-old's seventh such event,and he couldn't wait to celebrate at the finish line with his teenage son,who had raced ahead.Pham took another step or two,and that was the last thing he could remember.
基金support from the Lawrence Livermore National Laboratory(Grant No.B622827)the National Science Foundation(Grant Nos.1824568,1810506,1741707,and 1829071)the Office of Naval Research(Grant No.N00014-16-1-2094).
文摘Laser frequency microcombs provide a series of equidistant,coherent frequency markers across a broad spectrum,enabling advancements in laser spectroscopy,dense optical communications,precision distance metrology,and astronomy.Here,we design and fabricate silicon nitride,dispersion-managed microresonators that effectively suppress avoided-mode crossings and achieve close-to-zero averaged dispersion.Both the stochastic noise and mode-locking dynamics of the resonator are numerically and experimentally investigated.First,we experimentally demonstrate thermally stabilized microcomb formation in the microresonator across different mode-locked states,showing negligible center frequency shifts and a broad frequency bandwidth.Next,we characterize the femtosecond timing jitter of the microcombs,supported by precise metrology of the timing phase and relative intensity noise.For the single-soliton state,we report a relative intensity noise of−153.2 dB∕Hz,close to the shot-noise limit,and a quantum-noise–limited timing jitter power spectral density of 0.4 as 2∕Hz at a 100 kHz offset frequency,measured using a self-heterodyne linear interferometer.In addition,we achieve an integrated timing jitter of 1.7 fs±0.07 fs,measured from 10 kHz to 1 MHz.Measuring and understanding these fundamental noise parameters in high clock rate frequency microcombs is critical for advancing soliton physics and enabling new applications in precision metrology.
基金Supported by the National Key Research and Development Program,China,No.2022YFC2503603.
文摘BACKGROUND Bile duct leaks(BDLs)are serious postsurgical adverse events.Typically,conservative management with ab-dominal drainage is the initial treatment option.However,prolonged abdominal drainage without improvement can lead to biliary stricture and delay the optimal timing of endoscopic retrograde cholangiopancreatography(ERCP).AIM To identify the optimal timing for ERCP and the period during which clinical observation with conservative management is acceptable,balancing ERCP success and the risk of biliary strictures.METHODS We conducted a multicenter retrospective study involving 448 patients with BDLs between November 2002 and November 2022.The patients were divided into four groups based on the timing of ERCP:3 days,7 days,14 days,and 21 days.The primary outcome was clinical success,defined as the resolution of BDL and related symptoms within 6 months without additional percutaneous drainage,surgery,or death.The secondary outcome was incidence of biliary strictures.Univariate and multivariate logistic regression analyses were performed to identify factors associated with ERCP success and biliary stricture occurrence.RESULTS In a cohort of 448 consecutive patients diagnosed with BDLs,354 were excluded,leaving 94 patients who underwent ERCP.Clinical success was achieved in 84%of cases(79/94),with a median ERCP timing of 20 days(9.5-35.3 days).Biliary strictures were identified in 29(30.9%)patients.Performing ERCP within 3 weeks,compared to after 3 weeks,was associated with higher success rates[92.0%(46/50)vs 75.0%(33/44),P=0.032]and a lower incidence of biliary stricture incidence[18.0%(9/50)vs 45.5%(20/44),P=0.005].Subsequent multivariate analysis confirmed the association with higher success rates(odds ratio=4.168,P=0.045)and lower biliary stricture rates(odds ratio=0.256,P=0.007).CONCLUSION Performing ERCP for BDLs within 3 weeks may be associated with a higher success rate and a lower biliary stricture rate.If patients with BDLs do not respond to conservative treatment,ERCP is suggested to be performed within 3 weeks.
文摘Background:Rehabilitation typically restores shoulder function after a common rotator cuff repair;however,it is unclear when to initiate physical therapy(PT)post-surgery.To understand effective start times,this study analyzed PT start times and their effect on shoulder function.The most effective shoulder outcomes were hypothesized to occur when PT started 0-4 weeks post-surgery.Methods:Data from 1002 patients who underwent rotator cuff repair were analyzed retrospectively from 52 outpatient clinics in the years of 2016-2021.The primary data of timings between surgery and the start of PT(0-2 weeks[0-14 days],2-4 weeks[15-28 days],4-6 weeks[29-42 days],and 6-14 weeks[43-100 days]),change in functional shoulder scores,number of PT visits utilized,and functional scores changed per visit were analyzed.Regression analyses of the impact of age,sex,payor source,and tear size were completed.Results:The change in functional scores and functional scores changed per visit are not affected by the initiation timing of PT postrotator cuff surgery,when controlling for baseline functional scores.This result is revealed despite initial functional scores being significantly different.Functional scores change per visit may have been affected by payor source(R^(2)=0.004,p≤0.010).PT start times may have been impacted by age(R^(2)=0.010,p=0.007),payor source(R^(2)=0.016,p=0.001),and tear size(R^(2)=0.007,p=0.026).Payor source may have influenced the number of PT visits(R^(2)=0.060,p<0.001).Conclusions:After rotator cuff surgery,patients should choose to complete rehabilitation to optimize shoulder function.However,the initiation timing of PT may not affect functional shoulder outcomes.
基金Supported by Sichuan Science and Technology Program(No.2022JDKP0010).
文摘AIM:To investigate the optimal timing and therapeutic effects of cataract surgery in patients with moderate to severe thyroid-associated ophthalmopathy(TAO).METHODS:Data from TAO patients who underwent cataract surgery between 2014 and 2024 were analyzed.patients were categorized into two groups based on the hospital where their cataract surgery was performed:an external hospital surgery group and an in-house hospital surgery group.Patients in external hospital presenting with complications within six months postoperatively were assessed for clinical features,imaging,thyroid function,and outcomes.Patients who underwent surgery at West China Hospital were evaluated for clinical status,imaging,laboratory findings,and manifestations.RESULTS:In the external hospital group(n=31),common symptoms included eyelid swelling(64.52%)and diplopia(51.61%),with restricted eye movement in all patients.Most patients were in the active stage(87.10%)and exhibited various complications,such as dysthyroid optic neuropathy(DON)in 4 patients,misdiagnosis of glaucoma in 1 patient,and enucleation due to fungal infection in 1 patient.In the West China Hospital group(n=30),2 patients were in the active stage,and 28 were in the inactive stage.Postoperative visual acuity improved in 36 eyes,except for in 2 eyes with DON.Active TAO patients with mature cataracts had effective inflammation control and no complications at the 6-month follow-up.CONCLUSION:In patients with moderate to severe active TAO complicated by cataracts,delaying cataract surgery until 6mo of TAO control should be considered if cataracts are stable.Simultaneous anti-inflammatory treatment and cataract surgery should be performed for mature/hypermature cataracts,and TAO management should be continued after surgery.
基金supported in part by the National Key R&D Program of China under Grant 2021YFA0716600 and 2024ZD1300100in part by the National Natural Science Foundation of China under Grant 42274018,42425401,62371029,62271285 and U2233217.
文摘High-performance positioning,navigation and timing(PNT)service is critical to the safe flight of low-altitude aircraft and the effective management of low altitude traffic.In low-altitude economic sce-narios,the specificity of massive unmanned aerial ve-hicle(UAV)flights and the complexity of low-altitude airspace traffic management impose stringent demand on the high-continuity,high-accuracy,real-time,and high-security PNT service.However,the current PNT service,which primarily relies on Global Navigation Satellite System(GNSS),Micro-Electro-Mechanical System Inertial Navigation System(MEMS INS),etc.,is completely inadequate to support the future needs of low-altitude economic development.In order to bridge the huge gap between existing capability and future demand,a three-layer PNT architecture based on the collaboration of space-based,air-based and ground-based PNT systems is proposed for low-altitude econ-omy.The space-based layer consists of high,medium even possible low orbit GNSS constellations,such as BeiDou Navigation Satellite System(BDS),for high-precision,high-security absolute positioning and tim-ing.The air-based layer leverages inter-aircraft links for high-reliability dynamic relative positioning.The ground-based layer includes pseudolite network,as well as 5G-advanced(5G-A)/6G network,for more comprehensive coverage and real-time positioning.To this end,it is imperative to make breakthroughs in key technologies,from systems to airborne terminal,in-cluding but not limited to high-precision anti-jamming GNSS signal processing,high-reliability relative po-sitioning,real-time pseudolite positioning,and high-efficient multi-source information fusion at airborne terminal,etc.Due to the moderate redundancy,hetero-geneous mechanism,and multiple coverage from mul-tiple PNT systems,the proposed layered PNT archi-tecture possesses high robustness and resilient.Addi-tionally,the integration of INS,LiDAR and vision etc.perception technologies can significantly enhance the PNT capability.As a result,the proposed three-layer PNT architecture enable greater autonomy for low-altitude aircraft and intelligent traffic management for massive UAV operations,and promoting the safe and efficient development of the low-altitude economy.
基金supported by Open Fund (CRI2012RCPS0152CN) of State Key Laboratory of Offshore Oil Exploitationthe National Science and Technology Major Project (2011ZX05024-004-01)
文摘Polymer flooding has been proven to effectively improve oil recovery in the Bohai Oil Field. However, due to high oil viscosity and significant formation heterogeneity, it is necessary to further improve the displacement effectiveness of polymer flooding in heavy oil reservoirs in the service life of offshore platforms. In this paper, the effects of the water/oil mobility ratio in heavy oil reservoirs and the dimensionless oil productivity index on polymer flooding effectiveness were studied utilizing rel- ative permeability curves. The results showed that when the water saturation was less than the value, where the water/oil mobility ratio was equal to 1, polymer flooding could effectively control the increase of fractional water flow, which meant that the upper limit of water/oil ratio suitable for polymer flooding should be the value when the water/oil mobility ratio was equal to 1. Mean while, by injecting a certain volume of water to create water channels in the reservoir, the polymer flooding would be the most effective in improving sweep efficiency, and lower the fractional flow of water to the value corresponding to △Jmax. Considering the service life of the platform and the polymer mobility control capacity, the best polymer injection timing for heavy oil reservoirs was optimized. It has been tested for reservoirs with crude oil viscosity of 123 and 70 mPa s, the optimum polymer flooding effec- tiveness could be obtained when the polymer floods were initiated at the time when the fractional flow of water were 10 % and 25 %, respectively. The injection timing range for polymer flooding was also theoretically analyzed for the Bohai Oil Field utilizing which provided methods for effectiveness. relative permeability curves, improving polymer flooding
文摘To minimize the power consumption with resources operating at multiple voltages a time-constrained algorithm is presented.The input to the scheme is an unscheduled data flow graph (DFG),and timing or resource constraints.Partitioning is considered with scheduling in the proposed algorithm as multiple voltage design can lead to an increase in interconnection complexity at layout level.That is,in the proposed algorithm power consumption is first reduced by the scheduling step,and then the partitioning step takes over to decrease the interconnection complexity.The time-constrained algorithm has time complexity of O(n 2),where n is the number of nodes in the DFG.Experiments with a number of DSP benchmarks show that the proposed algorithm achieves the power reduction under timing constraints by an average of 46 5%.
基金The National Natural Science Foundation of China(No50378016)
文摘The pedestrian timing at signalized intersections is studied aiming at the problems of the inconsistency of the vehicular and pedestrian timing requirements and the insufficiency of pedestrian clearance. Based on the formulae of WALK and flashing DON＇T WALK （FDW） in the highway capacity manual （HCM）, the relationship between pedestrian signal indications and vehicular signal indications is discussed using the theory of traffic flow. Then, methods of pedestrian timing for different cases are established, particularly the methods of the pedestrian green adjustment. Ways of pedestrian crossing are analyzed for roadways with different forms and widths of the median island. The sampling values of calculation parameters are studied, and the recommended formulae of pedestrian timing for different conditions are presented.
文摘In order to synchronize the elements of the EAST Neutral Beam Injector （NBI） spatially located in several places, a distributed Timing System （TS） is developed in this paper. The timing system provides a clock reference for synchronization and an interlock protection of the EAST NBI system. It sends timing signals to field devices, controls the pulse widths of the timing sequences, and provides a sampling clock for the Data Acquisition System （DAS）. The timing system also generates analog waveforms to control power supplies and gas supplies according to the operator＇s configuration. The timing system is developed on a PXI （PCI eXtensions for Instrumentation） platform consisting of a LabVIEW workstation and a timing control terminal. The timing control terminal consists of a timing node and several control interface crates. Two timing nodes are configured in one beam line. Each node is responsible for the timing sequence, analog generation and feedback control for one ion source. The architecture and implementation of the timing system are presented in this paper.
文摘An algorithm of path based timing optimization by buffer insertion is presented.The algorithm adopts a high order model to estimate interconnect delay and a nonlinear delay model based on look up table for gate delay estimation.And heuristic method of buffer insertion is presented to reduce delay.The algorithm is tested by industral circuit case.Experimental results show that the algorithm can optimize the timing of circuit efficiently and the timing constraint is satisfied.
文摘A new approach of incremental placement approach is described.The obtained timing information drives an efficient net-based placement technique,which dynamically adapts the net weights during successive placement steps.Several methods to combine timing optimization and congestion reducing together are proposed.Cells on critical paths are replaced according to timing and congestion constraints.Experimental results show that our approach can efficiently reduce cycle time and enhance route ability.The max path delay is reduced by 10% on an average afterincremental placement on wirelength-optimized circuits.And it achieves the same quality with a high speed up compared to timing driven detailed placement algorithm.
基金This work was supported by the General Project of Humanities and Social Sciences Research of the Ministry of Education(16YJA740039,Sheng Xiao,2016)the Foundation Project of Philosophy and Social Science of Hunan(17YBA115,Sheng Xiao,2018).
文摘Timing speculative(TS)architecture is promising for improving the energy efficiency of microprocessors.Error recovery units,designed for tolerating occasional timing errors,have been used to support a wider range of voltage scaling,therefore to achieve a better energy efficiency.More specifically,the timing error rate,influenced mainly by data forwarding,is the bottleneck for voltage down-scaling in TS processors.In this paper,a new Timing Error Aware Register Allocation method is proposed.First,we designed the Dependency aware Interference Graph(DIG)construction to get the information of Read after Write(RAW)in programs.To build the construction,we get the disassemble code as input and suppose that there are unlimited registers,the same way as so-called virtual registers in many compilers.Then we change the disassemble codes to the SSA form for each basic block to make sure the registers are defined only once.Based on the DIG construction,registers were real-located to eliminate the timing error,by loosening the RAW dependencies.We con-struct the DIG for each function of the program and sort the edge of DIG by an increasing weight order.Since a smaller weighted-edge value means that its owner nodes have more frequent access in instruction flows,we expect it in different registers with no read-write dependency.At the same time,we make sure that there are no additional new spill codes emerging in our algorithm to minimize the rate of spill code.A high rate of spill code will not only decrease the performance of the system but also increase the unexpected read-write dependency.Next,we reallocate the reg-isters by weight order in turn to loosen the RAW dependencies.Furthermore,we use the NOP operation to pad the instructions with a minimal distance value of 2.Experiment results showed that the average distance of RAW dependencies was increased by over 20%.
