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Advances in prostate cancer treatment with moderate and ultrahypofractionated radiotherapy
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作者 Ling-Ling Meng Yu-Peng Di +1 位作者 Lin Ma Bao-Lin Qu 《World Journal of Clinical Oncology》 2025年第12期106-117,共12页
This article comprehensively reviews research progress in prostate cancer radiation therapy.It provides an overview of fundamental principles,encompassing the disease’s epidemiology,pathological mechanisms,and radiat... This article comprehensively reviews research progress in prostate cancer radiation therapy.It provides an overview of fundamental principles,encompassing the disease’s epidemiology,pathological mechanisms,and radiation sensitivity,alongside technological advancements.The clinical application,technological progress,and efficacy evaluation of moderate hypofractionated radiation therapy and ultra hypofractionated radiation therapy are discussed.Diagnostic and monitoring techniques specific to radiation therapy are analyzed,alongside prevailing controversies and challenges.Finally,the review outlines future prospects,including novel radiotherapy techniques,multidisciplinary collaboration trends,and the evolving role of radiation within comprehensive treatment.The findings demonstrate continuous technological and clinical evolution in prostate cancer radiotherapy,yet emphasize the need for further exploration to optimize treatments and improve patient survival and quality of life. 展开更多
关键词 Prostate cancer moderate Ultra-hypofractionated Radiation therapy TREATMENT Multidisciplinary collaboration
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Enhancing orthodontic osteodilated arch treatment through comprehensive nursing interventions and cognitive behavioral therapy
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作者 Haewon Byeon 《World Journal of Clinical Cases》 2025年第12期1-4,共4页
Orthodontic osteodilated arch treatment represents a pivotal approach in dental orthodontics to address dental crowding and misalignment.Integrating cognitive behavioral therapy(CBT)into comprehensive nursing interven... Orthodontic osteodilated arch treatment represents a pivotal approach in dental orthodontics to address dental crowding and misalignment.Integrating cognitive behavioral therapy(CBT)into comprehensive nursing interventions(CNI)aims to address these issues holistically.This editorial explores the effectiveness of CBTbased CNI in improving patient outcomes in orthodontic care.Innovations in remote CBT delivery,such as virtual reality,have also shown potential in reducing pain,anxiety,and depression,emphasizing CBT's adaptability in orthodontic settings.The findings underscore the importance of integrating psychological support into orthodontic care to enhance patient adherence,satisfaction,and overall treatment success.The editorial advocates for a holistic approach that combines psychological and physiological care,highlighting the transformative potential of CBT-based interventions in orthodontic treatment. 展开更多
关键词 Cognitive behavioral therapy comprehensive nursing interventions Orthodontic care Patient compliance Psychological well-being
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Comprehensive Rehabilitation Therapy of Traditional Chinese Medicine Combined with Modern Rehabilitation Training Improves the Spasticity and Motor Function of Hemiplegia after Stroke 被引量:1
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作者 Yijun Shen 《Journal of Clinical and Nursing Research》 2024年第3期82-88,共7页
Objective:To analyze the impact of comprehensive rehabilitation therapy of traditional Chinese medicine(TCM)(based on modern rehabilitation training)on the spasticity and motor function in stroke patients with hemiple... Objective:To analyze the impact of comprehensive rehabilitation therapy of traditional Chinese medicine(TCM)(based on modern rehabilitation training)on the spasticity and motor function in stroke patients with hemiplegia.Methods:Seventy-nine stroke and hemiplegia patients admitted to the hospital from June 2021 to June 2023 were selected and randomly divided into a control group(39 cases)using modern rehabilitation training,and an observation group combined with comprehensive TCM rehabilitation therapy(40 cases),over 1 month.The clinical index data of the two groups were compared.Results:There were differences in the clinical index data between the two groups.The total effective rate after 2 treatment in the observation group(92.50%)was higher than that of the control group(74.36%)(χ^(2)=4.727,P<0.05).All central sensitization inventory(CSI)and stroke quality of life(PRO)scores in both groups were lower after treatment,with the observation group having lower scores as compared to the control group(P<0.05).The scores of FMA(upper limbs,lower limbs),Barthel index scores,and Functional Ambulation Categories(FAC)scores of both groups increased after treatment,with the observation group having higher scores as compared to the control group(P<0.05).Conclusion:Comprehensive TCM rehabilitation therapy had a significant therapeutic effect on patients with hemiplegia after stroke.It improved the patient’s spasticity,limb movement,and walking function.Their daily living abilities and quality of life were also enhanced. 展开更多
关键词 Stroke Walking function HEMIPLEGIA comprehensive rehabilitation therapy of traditional chinese medicine SPASTICITY modern rehabilitation therapy
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Recent update on comprehensive therapy for advanced hepatocellular carcinoma 被引量:3
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作者 Hui Wang Wei Li 《World Journal of Gastrointestinal Oncology》 SCIE 2021年第8期845-855,共11页
Hepatocellular carcinoma(HCC)is one of the most common malignant tumors in the world.The treatment methods for HCC are diverse,mainly including surgical resection,ablation,and liver transplantation.The curative effect... Hepatocellular carcinoma(HCC)is one of the most common malignant tumors in the world.The treatment methods for HCC are diverse,mainly including surgical resection,ablation,and liver transplantation.The curative effect can be achieved only for early stage HCC,and it is easy to recur and metastasize after surgery,with a 5-year recurrence rate as high as 70%.Most patients with HCC are in the middle and advanced stage at the time of diagnosis and lose the chance of surgical resection.In recent years,with the in-depth study of the pathogenesis of HCC and the progress of medical science and technology,the systemic treatment of advanced HCC has made a breakthrough.At present,multidisciplinary comprehensive treatment including targeted therapy and immunotherapy has become an effective strategy and inevitable trend for the treatment of advanced HCC.Combined therapy has greatly improved the prognosis of HCC patients and opened up a new milestone in the treatment of this malignancy.In this article,we focus on the treatment progress of advanced HCC to further guide clinical practice. 展开更多
关键词 Hepatocellular carcinoma Local treatment Targeted therapy IMMUNOtherapy comprehensive therapy Multidisciplinary therapy
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Comprehensive Therapy of Pancreatic Cancer by Integrative Traditional and Western Medicine 被引量:10
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作者 刘鲁明 《Chinese Journal of Integrated Traditional and Western Medicine》 2004年第3期236-237,共2页
In recent 20 years, there has been an increasing trend in the incidence of pancreatic cancer both at home and abroad. An estimated 31 860 new cases and 31 270 deaths are expected to occur in the United States in 2004 ... In recent 20 years, there has been an increasing trend in the incidence of pancreatic cancer both at home and abroad. An estimated 31 860 new cases and 31 270 deaths are expected to occur in the United States in 2004 due to this disease, the 4th and 5th leading cause of cancer death for men and women respectively. In China, new cases of pancreatic cancer continue to increase and are 6 展开更多
关键词 In comprehensive therapy of Pancreatic Cancer by Integrative Traditional and Western Medicine
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Clinical Observation on Treatment of Moderate and Severe Periodical Mastalgia with TCM Hot-wet Compress Therapy 被引量:1
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作者 Qiao HUANG Yujian SUN +6 位作者 Na FU Fang XIE Hao DONG Wenjie ZHAO Chun WANG Huan LIANG Dongxiao ZHANG 《Medicinal Plant》 CAS 2018年第4期83-86,共4页
[Objectives] To observe the clinical therapeutic efficacy of local hot-wet compress therapy of digestion ointment prescription on the patients with moderate and severe mastalgia. [Methods] Firstly,60 patients with mas... [Objectives] To observe the clinical therapeutic efficacy of local hot-wet compress therapy of digestion ointment prescription on the patients with moderate and severe mastalgia. [Methods] Firstly,60 patients with mastalgia were selected,and divided into the experimental group and control group( 30 cases for each group). The control group was treated with acupuncture at distal point,and the experimental group was treated with TCM local hot-wet compress therapy combined with acupuncture at distal point. Then,the clinical therapeutic efficacy of two groups was compared. [Results]The experimental group was superior to the control group in relieving the breast pain,improving emotional integral,reducing breast lumps,improving lump texture,and improving TCM syndrome integral( P < 0. 05). [Conclusions]The digestion ointment prescription local hot-wet compress therapy has a significant therapeutic effect on treatment of mastalgia and can significantly improve the breast pain symptom of patients. 展开更多
关键词 Periodical mastalgia moderate SEVERE Hot-wet compress therapy Digestion ointment External therapy of TCM
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Use of Chinese Herbal Medicine Therapies in Comprehensive Hospitals in Central China: A Parallel Survey in Cancer Patients and Clinicians 被引量:3
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作者 陈刚 乔婷婷 +5 位作者 丁浩 李晨曦 郑慧玲 陈晓玲 胡少明 于世英 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第6期808-814,共7页
Summary: Chinese herbal medicine (CHM), as the largest application category of traditional Chinese medicine (TCM), is widely accepted among cancer patients in China. Herbal slice (HS) and Chinese patent drug (... Summary: Chinese herbal medicine (CHM), as the largest application category of traditional Chinese medicine (TCM), is widely accepted among cancer patients in China. Herbal slice (HS) and Chinese patent drug (CPD) are commonly used CHM in China. This study aimed to investigate the utilization of CHM among clinicians and cancer patients in central China. Five hundred and twenty-five patients and 165 clinicians in 35 comprehensive hospitals in central China were asked to complete an anonymous questionnaire that was designed to evaluate the use of CHM. The results showed that 90.74% clinicians and 72.24% cancer patients used CHM during cancer treatment. The educational backgrounds of the clinicians and the age, education level, annual income, and cancer stage of the cancer patients were re- lated to use of CHM. More than 90% clinicians and cancer patients had used CPD. Comparatively, the percentage of HS use was 10% lower than that of CPD use among clinicians and cancer patients. More clinicians preferred to use CHM after surgery than cancer patients did (20.41% vs. 5.37%). Enhancing physical fitness and improving performance status were regarded as the most potential effect of CHM on cancer treatment (85.71% among clinicians and 94.07% among cancer patients), in comparison with directly killing tumor cells (24.49% among clinicians and 31.36% among patients). As for refusal rea- sons, imprecise efficacy was the unanimous (100%) reason for clinicians' rejection of CHM, and 95.58% patients objected to using CHM also for this reason. Furthermore, the side effects of CHM were more concerned by clinicians than by patients (33.33% vs. 15.81%). In conclusion, our survey revealed that CHM was popularly accepted by clinicians and cancer patients in central China. The reasons of use and rejection of CHM were different between clinicians and cancer patients. 展开更多
关键词 A Parallel Survey in Cancer Patients and Clinicians Use of Chinese Herbal Medicine Therapies in comprehensive Hospitals in Central China
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Effects of comprehensive nursing with cognitive behavioral therapy in orthodontic osteodilated arch treatment 被引量:1
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作者 Xin Yang Zeng-Xiang Wang +3 位作者 Yu-Xing Tian Chao Peng Hui-Ning Yang Ying Wu 《World Journal of Clinical Cases》 SCIE 2024年第22期5051-5058,共8页
BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore... BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.METHODS Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of this.Before and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different groups.In addition,satisfaction and complications were comparatively analyzed.RESULTS Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance. 展开更多
关键词 Orthodontic osteodilated arch Cognitive behavior therapy comprehensive nursing intervention mode Nursing effect Pain management Oral care
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Clinical Observation on the Prevention and Treatment of Juvenile Mild Myopia with Traditional Chinese Medicine Comprehensive Therapy 被引量:1
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作者 Shujuan Han Jianchao Li +1 位作者 Yanmei Lv Ruiwen Wang 《Journal of Clinical and Nursing Research》 2022年第3期181-189,共9页
Objective:To observe the clinical effect of traditional Chinese medicine on the prevention and treatment ofjuvenile mild myopia.Methods:One hundred and twenty cases of juvenile mild myopia were randomly divided into s... Objective:To observe the clinical effect of traditional Chinese medicine on the prevention and treatment ofjuvenile mild myopia.Methods:One hundred and twenty cases of juvenile mild myopia were randomly divided into six groups,with 20 cases in each group:western medicine group,ultrasonic group,acupuncture group,auricular point group,traditional Chinese oral decoction group,and traditional Chinese medicine comprehensive therapy group.The therapeutic effects of the treatment administered to the six groups were compared.Result:In the post-treatment and follow-up stages,the visual acuity of the traditional Chinese medicine comprehensive therapy group significantly improved along with reduced diopter compared to the other groups(p<0.05).However,the axial length of the six groups had no significant change compared with that before treatment(p>0.05).There were no adverse reactions in any of the patients.Conclusion:In the treatment of juvenile mild myopia,traditional Chinese medicine comprehensive therapy has good therapeutic effect without any adverse reactions;thus,it is worthy of clinical promotion. 展开更多
关键词 Traditional Chinese medicine comprehensive therapy Prevention and treatment TEENAGERS Mild myopia
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Clinical efficacy observation of comprehensive ying needling therapy for mumps
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作者 Haiyan TIAN Mengbo XU 《World Journal of Acupuncture-Moxibustion》 CSCD 2018年第1期29-32,I0005,共5页
Objective: To compare the clinical efficacy difference between comprehensive ying needling therapy and intramuscular injection with ribavirin for mumps.Methods: One hundred patients with mumps were randomly divided ... Objective: To compare the clinical efficacy difference between comprehensive ying needling therapy and intramuscular injection with ribavirin for mumps.Methods: One hundred patients with mumps were randomly divided into comprehensive ying needling therapy group(group A, 52 cases) and western medicine group(group B, 48 cases), then 8 cases were eliminated and drop out from group A and 4 cases were eliminated and drop out from group B respectively. actual inclusion 44 cases in group A 44 cases in group B. Point bloodletting was performed at parotid gland(腮腺Sāixiàn) and Threeshang acupoints of the patients in group A for once every other day, treatment for 7 days was considered as 1 course of treatment, and 2 courses were needed. Intramuscular injection with ribavirin was given to the patients in group B for twice a day, treatment for 7 days was considered as 1 course, and 2 courses were needed. The parotid gland swelling score, fever score, orifice parotid duct swelling score, score of difficulty in opening mouth and the clinical efficacy of the patients in the two groups were compared before and after treatment.Results: The cured and markedly effective rate in group A was 90.9%(40/44), which was superior to 68.2%in group B(30/44)(P〈0.05). The symptom scores were all improved significantly in the two groups after treatment(all P〈0.05), and the improvement in group A was superior to that in group B(all P〈0.05).Conclusion: The curative effect of comprehensive ying needling therapy for treatment of mumps was superior to that of conventional western medicine therapy. 展开更多
关键词 MUMPS comprehensive ying needling therapy Ribavirin injection Randomized controlled trial
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Comprehensive Online Management Based on Cloud Platform for Breast Cancer Patients Using Dual-Targeted Therapy with Macromolecular Monoclonal Antibodies
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作者 Liping Zhang Qiaoling Zhong +5 位作者 Lili Han Lijuan Zhang Qinghua Luo Xinhua Xie Zeyu Shuang Na Li 《Journal of Cancer Therapy》 CAS 2022年第9期605-614,共10页
Objective: The purpose of the study was to explore the application effects of the cloud platform-based comprehensive online management for breast cancer patients using dual-targeted therapy with macromolecular monoclo... Objective: The purpose of the study was to explore the application effects of the cloud platform-based comprehensive online management for breast cancer patients using dual-targeted therapy with macromolecular monoclonal antibodies. Methods: 120 breast cancer patients treated by dual-targeted therapy with macromolecular monoclonal antibodies were managed by a cloud platform from March to November 2019. Comprehensive online management included consultation about drugs and side effects and frequently asked questions in the dual-targeted therapy with macromolecular monoclonal antibodies. Results: In the consultation about drugs and side effects, there were five patients with fever, neutrophil, cough, and fatigue;24 with diarrhea;25 with nausea;11 with oral mucosal inflammation;10 with rashes and dry skin;8 with insomnia;and 1 with palpitation. Moreover, 110 patients with anxiety about the missed or delayed treatment were properly handled. Conclusion: The comprehensive online management of dual-targeted therapy with macromolecular monoclonal antibodies based on the cloud platform is helpful to satisfy the at-home breast cancer patients’ needs, ensure the continuity of dual-targeted therapy with macromolecular monoclonal antibodies for breast cancer patients, prevent misinformation, alleviate patients’ negative psychological emotions, and reduce patients’ economic losses. The online cloud platform integrated management model is crucial for managing patients with breast cancer treated by dual-targeted therapy. 展开更多
关键词 Breast Cancer Dual-Targeted therapy with Macromolecular Monoclonal An-tibodies Cloud Platform comprehensive Online Management
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Study on the Clinical Effect of Comprehensive Nursing for Psychotic Patients Receiving Modified Electroconvulsive Therapy
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作者 XIONG Xin 《外文科技期刊数据库(文摘版)医药卫生》 2021年第2期445-448,共4页
Objective: to study the effect of comprehensive nursing care for psychotic patients treated with modified electroconvulsive therapy. Methods: 84 psychotic patients admitted to hospital from November 2019 to November 2... Objective: to study the effect of comprehensive nursing care for psychotic patients treated with modified electroconvulsive therapy. Methods: 84 psychotic patients admitted to hospital from November 2019 to November 2020 were randomly divided into reference group and experimental group with 42 cases in each group. All patients need to receive the treatment of modified electroconvulsive therapy. The patients in the reference group use routine care, while the patients in the experimental group use comprehensive care. The quality of life and ability of the two groups were compared. Results: there was significant difference in ability improvement between the two groups (P < 0.05). There was no significant difference in the scores before nursing between the two groups (P > 0.05). After nursing, the difference between the two groups was significant (P < 0.05). Conclusion: the effect of comprehensive nursing is more ideal, the ability to improve their lives, so that patients can gradually recover in treatment and nursing, which is worthy of promotion and application. 展开更多
关键词 modified electroconvulsive therapy PSYCHOSIS comprehensive nursing
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Effect of Comprehensive Nursing on Hormone Therapy of Patients with Rheumatic Immune Disease
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作者 HAN Shuangshuang WANG Min 《外文科技期刊数据库(文摘版)医药卫生》 2021年第4期235-239,共5页
Objective: to explore the effect of comprehensive nursing on hormone therapy in patients with rheumatic diseases. Methods: by random sampling, 68 patients who underwent rheumatic immunotherapy in our hospital from Nov... Objective: to explore the effect of comprehensive nursing on hormone therapy in patients with rheumatic diseases. Methods: by random sampling, 68 patients who underwent rheumatic immunotherapy in our hospital from November 2019 to November 2020 were selected as the subjects of this study. Then 68 cases were randomly divided into 2 groups by random number table method. According to the research needs, the two groups of patients were treated differently. The control group provided routine nursing and the observation group provided comprehensive nursing. After the treatment, the treatment compliance and nursing quality evaluation of the two groups of patients were statistically analyzed. Results: after the two groups of patients were given different nursing, the scores of health education, nursing skills, medication guidance and service attitude of the patients in the control group were 18.45±2.61, 19.87±2.39, 20.74±2.35 and 19.87±2.27. The scores of patients in the observation group were 23.65±2.44, 24.07±2.22, 23.71±2.41 and 23.79±2.48, which were significantly higher than those in the control group. In the control group, the scores of health education, nursing skills, medication guidance and service attitude were 18.45±2.61, 19.87±2.39, 20.74±2.35 and 19.87±2.27. The scores of health education, nursing skills, medication guidance and service attitude of the patients in the observation group were 23.65±2.44, 24.07±2.22, 23.71±2.41 and 23.79±2.48, which were significantly higher than those in the control group in terms of nursing quality. There was a general significant difference between the two groups (p < 0.05). Conclusion: comprehensive nursing has a significant impact on hormone therapy for patients with rheumatic immune diseases, which is mainly manifested in improving the treatment compliance of patients and enhancing the clinical nursing effect, and is worthy of wide clinical application. 展开更多
关键词 rheumatism immunity comprehensive care hormone therapy
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Effect of Stereoscopic Comprehensive Therapy of Zhuang Medicine on Inflammatory Factor IL-6 in Patients with Rheumatoid Arthritis
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作者 Xiusong Tang Yanqiang Chen +2 位作者 Yuzhi Shang Yulei Fu Yuzhou Pang 《Journal of Clinical and Nursing Research》 2021年第3期19-23,共5页
Objective:To study the effect of Stereoscopic Comprehensive of Therapy Zhuang Medicine on IL-6 in serum of patients with rheumatoid arthritis.Methods:Sixty rheumatoid arthritis patients who met the inclusion criteria ... Objective:To study the effect of Stereoscopic Comprehensive of Therapy Zhuang Medicine on IL-6 in serum of patients with rheumatoid arthritis.Methods:Sixty rheumatoid arthritis patients who met the inclusion criteria were selected and randomly divided into a control group and a treatment group using a random number table.Among them,30 cases in the control group were treated with Western medicine,and 30 cases in the treatment group were treated with Western medical and Stereoscopic Comprehensive Therapy of Zhuang Medicine.The observation period was 8 weeks.Results:After 8 weeks of treatment,the level of IL-6 in the treatment group and the control group decreased,and the treatment group was better than the control group(P<0.05).Conclusion:The Stereoscopic Comprehensive of Zhuang Medicine can reduce the level of IL-6 in the serum of patients with rheumatoid arthritis,and has a good regulating effect on the inflammation of rheumatoid arthritis. 展开更多
关键词 Rheumatoid arthritis Stereoscopic comprehensive therapy of Zhuang medicine Inflammatory factors Interleukin 6
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Effects of Exercise Therapy Combined with Family Comprehensive Intervention on Quality of Life and Pulmonary Function in Patients with Stable COPD
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作者 WANG Mei YU Hao +2 位作者 YAO Shunmin YANG Guangping XIA Hongshuang 《外文科技期刊数据库(文摘版)医药卫生》 2021年第7期410-412,共5页
Objective: to explore the improvement of life quality and lung function before and after exercise therapy combined with family comprehensive intervention in the rehabilitation treatment of COPD patients in stable peri... Objective: to explore the improvement of life quality and lung function before and after exercise therapy combined with family comprehensive intervention in the rehabilitation treatment of COPD patients in stable period. Methods: this study was carried out on 200 patients with stable COPD admitted by the respiratory department of Wudang district people's hospital of Guiyang (January 2019 to January 2021). They were randomly divided into control group (exercise therapy) and treatment group (exercise therapy + family comprehensive intervention). The quality of life, lung function and other indicators of patients before and after intervention were evaluated to determine the practical value of the combined rehabilitation treatment scheme. Results: the scores of all items of quality of life scale in the treatment group were higher than those in the control group (P < 0.05);The data of pulmonary function indexes in the treatment group were significantly improved and changed significantly, which was better than that in the control group (P < 0.05). Conclusion: in the rehabilitation treatment of patients with COPD in stable period, the effect of combined therapy is relatively significant, that is, exercise therapy + family comprehensive intervention. Patients can achieve a strong sustained treatment intervention, their quality of life and lung function are improved, to achieve the improvement of the prognosis of patients. 展开更多
关键词 COPD patients in stable stage exercise therapy family comprehensive intervention quality of life
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Comprehensive single-cell profiling uncovers TsMHC-Ⅱ expression predicting response to neoadjuvant immunotherapy in gastric cancer
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作者 Zhiyuan Xu Zhichun Tang +18 位作者 Simeng Hu Litao Yang Jingli Xu Pengfei Yu Yian Du Yanqiang Zhang Jiahui Chen Xiaoxiao Wu Siwei Pan ShengJie Zhang Ling Huang Qing Wei Ruolan Zhang Wujie Chen Haibin Wei Wei Sun Can Hu Fan Bai Xiangdong Cheng 《Science Bulletin》 2026年第4期727-731,共5页
Gastric cancer(GC)is the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide,with China bearing nearly half of the global burden[1,2].Most patients are diagnosed at stage Ⅲ–Ⅳ... Gastric cancer(GC)is the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide,with China bearing nearly half of the global burden[1,2].Most patients are diagnosed at stage Ⅲ–Ⅳ,and despite perioperative therapy plus D2 gastrectomy being the standard of care,long-term survival remains poor[3,4]. 展开更多
关键词 gastric cancer gc perioperative therapy neoadjuvant immunotherapy comprehensive single cell profiling gastric cancer long term survival TSMHC II expression d gastrectomy
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血清GRP78、RANTES水平与冠心病患者冠状动脉病变严重程度、主要不良心血管事件的相关性
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作者 杨淑玲 乔亚京 +1 位作者 刘翔宇 杨定宪 《临床心身疾病杂志》 2026年第2期39-43,53,共6页
目的探究血清葡萄糖调节蛋白(GRP78)、活化T细胞趋化因子(RANTES)水平与冠心病(CHD)患者冠状动脉病变严重程度、主要不良心血管事件(MACE)的相关性。方法选取120例CHD患者为研究对象,收集患者基线资料,检测患者实验室指标及血清GRP78、R... 目的探究血清葡萄糖调节蛋白(GRP78)、活化T细胞趋化因子(RANTES)水平与冠心病(CHD)患者冠状动脉病变严重程度、主要不良心血管事件(MACE)的相关性。方法选取120例CHD患者为研究对象,收集患者基线资料,检测患者实验室指标及血清GRP78、RANTES水平。采用Spearman相关分析探讨患者血清GRP78、RANTES水平与Gensini总分的相关性;采用Logistic回归分析探讨CHD患者发生MACE的影响因素,绘制受试者工作特征(ROC)曲线分析血清GRP78、RANTES水平对CHD患者发生MACE的预测价值。结果根据Gensini总分,轻度病变组53例,中度病变组37例,重度病变组30例。三组患者血清GRP78及RANTES水平比较,差异均有统计学意义(P<0.01)。血清GRP78与RANTES水平随冠状动脉病变严重程度的加重而升高(P<0.01)。Spearman相关分析显示,患者血清GRP78、RANTES水平与Gensini总分均呈显著正相关(P<0.01)。120例患者中,发生MACE者34例(28.33%),未发生MACE者86例(71.67%)。发生与未发生MACE的患者在年龄、左主干病变及低密度脂蛋白胆固醇、GRP78、RANTES水平方面比较,差异均有统计学意义(P<0.05或0.01)。Logistic回归分析结果显示:年龄、左主干病变及GRP78、RANTES水平是CHD患者发生MACE的影响因素(P<0.05或0.01)。ROC曲线显示,血清GRP78、RANTES水平单独及联合预测患者术后MACE的曲线下面积为0.841、0.849、0.898,两者联合预测优于单独预测(P<0.05)。结论CHD患者血清GRP78、RANTES水平显著升高,且与冠状动脉病变严重程度和患者术后MACE相关,联合检测可提高对CHD患者术后MACE的预测价值。 展开更多
关键词 冠心病 葡萄糖调节蛋白78 活化T细胞趋化因子 冠状动脉病变严重程度 主要不良心血管事件
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音乐疗法联合感觉统合训练对全面发育迟缓患儿生长发育及照顾者心理状况的影响
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作者 吴会丽 周晶晶 +3 位作者 王艳艳 高智玉 粱疆芳 谷艳霞 《中国健康心理学杂志》 2026年第2期183-187,共5页
目的:探讨音乐疗法联合感觉统合训练对全面发育迟缓患儿生长发育及照顾者心理状况的影响。方法:选择2019年1月至2024年12月某院收治的全面发育迟缓患儿120例作为研究对象,采用随机数表法分为观察组及对照组各60例。对照组给予感觉统合训... 目的:探讨音乐疗法联合感觉统合训练对全面发育迟缓患儿生长发育及照顾者心理状况的影响。方法:选择2019年1月至2024年12月某院收治的全面发育迟缓患儿120例作为研究对象,采用随机数表法分为观察组及对照组各60例。对照组给予感觉统合训练,观察组给予音乐疗法联合感觉统合训练。两组均干预6个月,比较两组护理效果、护理6个月后生长发育情况(身高、体质量及生长速率)、照顾者心理状况[汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)]、神经发育评估量表(GDS-C)5个领域发育商(运动领域、个人与社会领域、语言能力、手眼协调领域、表现领域)、口面部运动能力。结果:观察组护理有效率高于对照组(χ^(2)=4.183,P<0.05),差异有统计学意义;护理6个月后,两组患儿身高、体质量及生长速率均升高,且观察组高于对照组(t=2.321,2.607,2.087;P<0.05),差异有统计学意义;两组患儿HAMA、HAMD评分降低,且观察组低于对照组(t=-2.387,-2.503;P<0.05),差异有统计学意义;两组患儿运动领域、个人与社会领域、语言能力、手眼协调领域及表现领域评分均升高,且观察组高于对照组(t=2.503,2.371,2.028,2.602,3.045;P<0.05),差异有统计学意义;两组患儿口面部运动能力评分均升高,且观察组高于对照组(t=2.225,P<0.05),差异有统计学意义。结论:音乐疗法联合感觉统合训练在全面发育迟缓患儿中的应用效果良好,可改善患儿生长发育及照顾者心理状况。 展开更多
关键词 全面发育迟缓 音乐疗法 感觉统合训练 生长发育 心理状况
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不同治疗方案对6~9岁注意缺陷多动障碍患儿疗效的对比研究
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作者 朱才荣 江蕙芸 +2 位作者 蒙晓梅 沈榕 覃秋萍 《发育医学电子杂志》 2026年第1期20-27,共8页
目的探究不同治疗方案对6~9岁注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿的治疗效果。方法采用病例对照研究方法,选取2020年3月至2022年1月于广西壮族自治区妇幼保健院治疗的218例ADHD患儿为研究对象,按照... 目的探究不同治疗方案对6~9岁注意缺陷多动障碍(attention deficit hyperactivity disorder,ADHD)患儿的治疗效果。方法采用病例对照研究方法,选取2020年3月至2022年1月于广西壮族自治区妇幼保健院治疗的218例ADHD患儿为研究对象,按照治疗方法不同将其分为家长培训组(n=35)、联合执行功能训练组(n=40)、联合药物治疗组(n=75)、综合治疗组(n=68)。家长培训组:只对ADHD患儿的家长进行培训;联合执行功能训练组:在家长培训的基础上,再对ADHD患儿进行执行功能训练;联合药物治疗组:在家长培训的基础上,给予ADHD患儿盐酸哌甲酯缓释片(Methylphenidate sustained-release tablets,MPH)药物治疗;综合治疗组:在家长培训的基础上,联合MPH药物治疗和执行功能训练。比较4组患儿治疗前后在视听整合持续操作测验(Integrated Visual and Auditory Continuous Performance Test,IVA-CPT)、韦氏儿童智力量表第四版(Wechsler Intelligence Scale for Children-Fourth Edition,WISC-Ⅳ)、中文版SNAP-IV量表(Swanson,Nolan,and Pelham,SNAP-Ⅳ)父母版中的评分差异。统计学方法采用方差分析、LSD-t检验和χ^(2)检验。结果治疗后,IVA-CPT评分结果显示,联合执行功能训练组、联合药物治疗组及综合治疗组患儿的多动商数和注意商数均显著高于家长培训组[多动商数:(94.38±26.37)分、(94.48±18.02)分、(101.37±15.27)分与(67.03±16.03)分,F=28.927,P<0.001;注意商数:(80.08±19.28)分、(82.36±25.32)分、(86.69±20.99)分与(72.11±26.53)分,F=3.121,P=0.027)];联合药物治疗组及综合治疗组患儿的注意商数优于联合执行功能训练组,差异均有统计学意义(P值均<0.05)。治疗后,WISC-Ⅳ评分结果显示,联合执行功能训练组、联合药物治疗组和综合治疗组患儿的言语理解指数、知觉推理指数、加工速度指数和总智商均高于家长培训组[言语理解指数:(84.90±10.65)分、(89.76±12.80)分、(88.43±10.95)分与(77.89±10.47)分,F=9.446,P<0.001);知觉推理指数:(90.00±12.74)分、(96.52±11.10)分、(99.74±14.42)分与(84.40±15.00)分,F=12.612,P<0.001);加工速度指数:(90.95±10.53)分、(94.09±11.30)分、(95.43±11.03)分与(82.91±12.45)分,F=10.637,P<0.001);总智商:(86.80±8.51)分、(92.16±9.36)分、(95.29±10.78)分与(78.54±9.90)分,F=25.338,P<0.001)],且联合药物治疗组与综合治疗组患儿的上述指标均优于联合执行功能训练组,(P值均<0.05)。治疗后,SNAP-Ⅳ评分结果显示,联合执行功能训练组、联合药物治疗组和综合治疗组患儿的注意力、多动冲动、对立违抗症状改善程度均优于家长培训组[注意力:(1.29±0.53)分、(1.15±0.40)分、(1.08±0.51)分与(2.29±0.49)分,F=57.167,P<0.001);多动冲动:(1.15±0.49)分、(0.99±0.63)分、(1.01±0.40)分与(1.51±0.41)分,F=9.633,P<0.001);对立违抗:(1.24±0.42)分、(1.00±0.49)分、(0.86±0.50)分与(1.70±0.33),F=28.158,P<0.001)],且联合药物治疗组与综合治疗组患儿的上述指标均优于联合执行功能训练组,(P值均<0.05)。结论对于6~9岁ADHD患儿,综合治疗及MPH药物治疗效果最佳,执行功能训练效果中等。执行功能训练作为一种非药物治疗手段,为ADHD早期干预提供了新方向。 展开更多
关键词 注意缺陷多动障碍 家长培训 综合治疗 药物治疗 执行功能训练
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综合营养支持策略对慢性阻塞性肺疾病急性加重患者氧疗效果的影响
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作者 程清 许杰超 +2 位作者 吴雁 渠慎强 刘晓慧 《医学工程与医用气体》 2026年第1期35-38,共4页
目的探讨综合营养支持策略对经鼻高流量氧疗(HFNC)的慢性阻塞性肺疾病急性加重(AECOPD)患者临床预后的影响。方法选择2023年5月至2025年4月江苏省中西医结合医院收治的96例AECOPD患者,使用SPSS 23.0软件生成随机数字将患者分为试验组和... 目的探讨综合营养支持策略对经鼻高流量氧疗(HFNC)的慢性阻塞性肺疾病急性加重(AECOPD)患者临床预后的影响。方法选择2023年5月至2025年4月江苏省中西医结合医院收治的96例AECOPD患者,使用SPSS 23.0软件生成随机数字将患者分为试验组和对照组。两组均给予HFNC,对照组给予常规肠内营养,试验组给予肠内与肠外相结合的综合营养支持策略。对比两组血清白蛋白(ALB)、血红蛋白(Hb)、转铁蛋白(TF)、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、白介素10(IL-10)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)水平以及临床预后不良率。结果治疗7 d后,试验组Hb、ALB、TF、PaO_(2)水平均高于对照组(P<0.05),PaCO_(2)、IL-10、hs-CRP、TNF-α水平均低于对照组(P<0.05);随访3个月,试验组临床预后不良率低于对照组(P<0.05)。结论相比于单纯肠内营养,综合营养支持策略能进一步改善AECOPD患者营养状态,增强HFNC治疗效果,减轻炎症反应,改善临床预后。 展开更多
关键词 综合营养支持策略 经鼻高流量氧疗 慢性阻塞性肺疾病 临床预后
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