In this paper, we consider the optimal problem of channels sharing with het-erogeneous traffic （real-time service and non-real-time service） to reduce the data conflict probability of users. Moreover, a multi-dimens...In this paper, we consider the optimal problem of channels sharing with het-erogeneous traffic （real-time service and non-real-time service） to reduce the data conflict probability of users. Moreover, a multi-dimensional Markov chain model is developed to analyze the performance of the proposed scheme. Meanwhile, performance metrics are derived. Numerical results show that the proposed scheme can effectively reduce the forced termination probability, blocking probability and spectrum utilization.展开更多
Background:The mechanism by which ibrutinib,a Bruton's tyrosine kinase inhibitor,can elevate the risk of arrhythmias is not fully elucidated.In this study,we explored how inhibition of off‐target kinases can cont...Background:The mechanism by which ibrutinib,a Bruton's tyrosine kinase inhibitor,can elevate the risk of arrhythmias is not fully elucidated.In this study,we explored how inhibition of off‐target kinases can contribute to this phenomenon.Methods:We performed a Mendelian randomization analysis to examine the causal associations between genetically proxied inhibition of six putative ibrutinib drug targets(ErbB2/HER2,CSK,JAK3,TEC,BLK,and PLCG2)and the atrial fibrillation(AF)risk,proarrhythmic ECG indices,and cardiometabolic traits and diseases.Inverse‐variance weighted random‐effects models and Wald ratio were used to examine the associations between genetically proxied inhibition of these drug targets and the risk of outcomes.Colocalization analyses were employed to examine the robustness of the causally significant findings.ELISAs were used to measure ErbB2 levels in intracardiac plasma samples.Results:Genetically proxied ErbB2 inhibition was associated with an increased AF risk,higher P wave terminal force,and prolonged QTc interval.Patients with AF had significantly higher intracardiac ErbB2 levels compared with patients with paroxysmal supraventricular tachycardia.CSK inhibition prolonged the QRS duration,decreased the QTc interval,and was potentially linked to conduction blocks.PLCG2 inhibition led to decreased P wave terminal force,shorter QTc interval,and increased risk of left bundle branch block.BLK inhibition shortened the QTc interval and was also associated with atrioventricular block.Conclusion:The off‐target effects and downstream targets of ibrutinib,including CSK,PLCG2,ERBB2,TEC,and BLK,may lead to cardiac electrical homeostasis imbalances and lethal cardiovascular diseases.Using drugs that inhibit these targets should be given extra caution.展开更多
The percentages of blocking and forced termination rates as parameters representing quality of services （QoS） requirements are presented. The relation between the connection statistics of mobile users in a cell and ...The percentages of blocking and forced termination rates as parameters representing quality of services （QoS） requirements are presented. The relation between the connection statistics of mobile users in a cell and the handoff number and new call number in next duration in each cell is explored. Based on the relation, statistic reservation tactics are raised. The amount of bandwidth for new calls and handoffs of each cell in next period is determined by using the strategy. Using this method can guarantee the communication system suits mobile connection request dynamic. The QoS parameters： forced termination rate and blocking rate can be maintained steadily though they may change with the offered load, Some numerical experiments demonstrate this is a practical method with affordable overhead.展开更多
基金supported in part by the National Natural Science Foundation of China(60972016,61231010)the Funds of Distinguished Young Scientists(2009CDA150)+1 种基金China-Finnish Cooperation Project(2010DFB10570)Specialized Research Fund for the Doctoral Program of Higher Education(20120142110015)
文摘In this paper, we consider the optimal problem of channels sharing with het-erogeneous traffic （real-time service and non-real-time service） to reduce the data conflict probability of users. Moreover, a multi-dimensional Markov chain model is developed to analyze the performance of the proposed scheme. Meanwhile, performance metrics are derived. Numerical results show that the proposed scheme can effectively reduce the forced termination probability, blocking probability and spectrum utilization.
基金funded by the National Natural Science Foundation of China(Grant Nos.81930105 and 82370312).
文摘Background:The mechanism by which ibrutinib,a Bruton's tyrosine kinase inhibitor,can elevate the risk of arrhythmias is not fully elucidated.In this study,we explored how inhibition of off‐target kinases can contribute to this phenomenon.Methods:We performed a Mendelian randomization analysis to examine the causal associations between genetically proxied inhibition of six putative ibrutinib drug targets(ErbB2/HER2,CSK,JAK3,TEC,BLK,and PLCG2)and the atrial fibrillation(AF)risk,proarrhythmic ECG indices,and cardiometabolic traits and diseases.Inverse‐variance weighted random‐effects models and Wald ratio were used to examine the associations between genetically proxied inhibition of these drug targets and the risk of outcomes.Colocalization analyses were employed to examine the robustness of the causally significant findings.ELISAs were used to measure ErbB2 levels in intracardiac plasma samples.Results:Genetically proxied ErbB2 inhibition was associated with an increased AF risk,higher P wave terminal force,and prolonged QTc interval.Patients with AF had significantly higher intracardiac ErbB2 levels compared with patients with paroxysmal supraventricular tachycardia.CSK inhibition prolonged the QRS duration,decreased the QTc interval,and was potentially linked to conduction blocks.PLCG2 inhibition led to decreased P wave terminal force,shorter QTc interval,and increased risk of left bundle branch block.BLK inhibition shortened the QTc interval and was also associated with atrioventricular block.Conclusion:The off‐target effects and downstream targets of ibrutinib,including CSK,PLCG2,ERBB2,TEC,and BLK,may lead to cardiac electrical homeostasis imbalances and lethal cardiovascular diseases.Using drugs that inhibit these targets should be given extra caution.
文摘The percentages of blocking and forced termination rates as parameters representing quality of services （QoS） requirements are presented. The relation between the connection statistics of mobile users in a cell and the handoff number and new call number in next duration in each cell is explored. Based on the relation, statistic reservation tactics are raised. The amount of bandwidth for new calls and handoffs of each cell in next period is determined by using the strategy. Using this method can guarantee the communication system suits mobile connection request dynamic. The QoS parameters： forced termination rate and blocking rate can be maintained steadily though they may change with the offered load, Some numerical experiments demonstrate this is a practical method with affordable overhead.
