Alkynyl selenides were prepared under very mild conditions by reacting terminal alkynes with respective diorganic diselenides in the presence of potassium t-butoxide. The advantages of this protocol include the use of...Alkynyl selenides were prepared under very mild conditions by reacting terminal alkynes with respective diorganic diselenides in the presence of potassium t-butoxide. The advantages of this protocol include the use of readily available substrates and reagent and good yield of the products.展开更多
A highly efficient and regio-/stereoselective method of hydrosilylating terminal alkynes was developed using Pt(DVDS)-tri(t-butyl) phosphine catalyst system at room temperature.Trans-products or alpha-products were ob...A highly efficient and regio-/stereoselective method of hydrosilylating terminal alkynes was developed using Pt(DVDS)-tri(t-butyl) phosphine catalyst system at room temperature.Trans-products or alpha-products were obtained almost exclusively depending on the alkynes and silanes employed.展开更多
Bottom-up approach to constructing low-dimensional nanostructures on surfaces with terminal alkynes has drawn great interest because of its potential applications in fabricating advanced functional nanomaterials. The ...Bottom-up approach to constructing low-dimensional nanostructures on surfaces with terminal alkynes has drawn great interest because of its potential applications in fabricating advanced functional nanomaterials. The diversity of the achieved products manifests rich chemistry of terminal alkynes and hence careful linking strategies and proper controlling methodologies are required for selective preparations of high-quality target nanoarchitectures. This review summarizes various on-surface linking strategies for terminal alkynes, including non-bonding interactions as well as organometallic and covalent bonds, and presents examples to show effective control of surface assemblies and reactions of terminal alkynes by variations of the precursor structures, substrates and activation modes. Systematic studies of the on-surface linkage of terminal alkynes may help efficient and predictable preparations of surface nanomaterials and further understanding of surface chemistry.展开更多
A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly u...A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly under mild conditions, and provided a practical approach for the synthesis of a wide range of 5‐alkynyl‐2‐pyrrolidinones in moderate to good yields （45%–76%）.展开更多
The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low(400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multigram scale. It ...The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low(400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multigram scale. It is suitable for the synthesis of alkenes labeled with deuterium, and for the late-stage modification of bioactive molecules.展开更多
The stereospecific carbocupration of terminal alkynes via higher order cuprates to give 1,1'-disubstituted olefins with 99% configuration purity is described. Its synthetic utility as a general method for the prep...The stereospecific carbocupration of terminal alkynes via higher order cuprates to give 1,1'-disubstituted olefins with 99% configuration purity is described. Its synthetic utility as a general method for the preparation of substituted olefins is further illustrated by the direct synthesis of (±)-ipsenol and (E)-β-farnesene with highly geometric purity of the carbon-carbon double bond.展开更多
Readily prepared chiral bis(imidazoline)NCN pincer iridium(III)complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes to trifluoropyruvates...Readily prepared chiral bis(imidazoline)NCN pincer iridium(III)complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes to trifluoropyruvates.With a catalyst loading of 5 mol%,a variety of optically activeα-trifluoromethylated tertiary propargylic alcohols were thus produced in good yields with high enantioselectivity(27 examples,74%–96%ee).Both enantiomers of the catalysis products were obtained by using enantiomeric Ir(III)catalysts.In addition,gram scale synthesis of the product and its transformation to a potentially very useful 2H-1,2,3-triazole compound were accomplished.Control experiments suggested that the alkynylide Ir(III)intermediates were involved in the reactions.展开更多
Transition metal-catalyzed hydrostannylation of alkynes is an atom-economic way towards valuableα-vinylstannanes.However,directing-group-free examples for the construction ofα-adducts are rare and mostly undergo the...Transition metal-catalyzed hydrostannylation of alkynes is an atom-economic way towards valuableα-vinylstannanes.However,directing-group-free examples for the construction ofα-adducts are rare and mostly undergo the M-Sn species insertion process.Here,we report an efficient cobalt-catalyzed highlyα-selective hydrostannylation of terminal alkynes via M-H species,using readily available Bu3Sn H and easily accessible as well as bench-stable ligand.The robust catalytic system,bearing good functional group tolerance and operational simplicity,provides theα-vinylstannanes in moderate to excellent yields with≥97:3 rr averagely.The efficiency of the reaction is investigated with turnover number(TON)up to 10,000 and turnover frequency(TOF)up to 144,000 h^(-1),respectively.The synthetic utility of theα-vinylstannanes is proved by further derivatizations towards the 1,1-disubstituted alkenes via Kosugi-Migita-Stille cross-coupling,conjugated alkene,α-vinyliodine,α-vinylazide,and allyl alcohol.Several control experiments,deuterium-labeling experiment and density functional theory(DFT)calculations are conducted to reveal the preliminary mechanism.展开更多
Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make ...Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign.Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign.展开更多
The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,...The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,and organic functional materials,etc.However,due to the inherent issues of the stereo-,regio-,and chemoselectivity,the strategy is less explored and remains problematic in substrate scope,selectivity,and screening of catalytic system,etc.Herein,a specific cross-dimerization of terminal alkynes is developed under Pd/TMEDA catalysis,which produces a series of gem-1,3-enynes(58 examples)in totally moderate to high yields with outstanding functional group tolerance.A cyclopalladium compound might be the key imtermediate,which performs anti-addition-carbometallation,and leads to the exclusive cross-selectivity.The unprecedented features of the reaction,such as anti-addition-carbometallation,easy control of selectivity,wide range of the donor alkynes,and very simple catalytic conditions,allow it not only a facile and functionally diverse synthesis of 1,3-enynes,but also a substantial progress for the textbook reaction.展开更多
The efficient utilization of visible light catalysts for organic reactions necessitates not only the effective separation of photogenerated electrons and holes to participate in the reaction,but also their ability to ...The efficient utilization of visible light catalysts for organic reactions necessitates not only the effective separation of photogenerated electrons and holes to participate in the reaction,but also their ability to form key intermediates with reactant molecules.The present study successfully synthesized a crusiform-like mesoporous structure of nitrogen-doped carbon-coated Cu_(2)O/Cu(Cu_(2)O/Cu/N-C)with a Cu_(2)O/dual electron acceptor interface using etched HKUST-1 as the precursor.A series of theoretical and experimental studies have demonstrated that the Cu_(2)O/Cu/N-C interface in the photocatalytic homo-coupling of terminal alkynes not only effectively enhances the separation of photogenerated electron−hole pairs,but also facilitates the formation of the key intermediate[Cu_(2)O/Cu/N-C]-phenylacetylide and promotes the rearrangement of its internal charges.As a result,the homo-coupling reaction can be effectively facilitated.The primary reason for the functional role of Cu_(2)O/Cu/N-C interface lies in the downward bending of energy band from Cu_(2)O to N-doped C layers,induced by the different work functions of Cu_(2)O,Cu and N-doped C layers.Consequently,Cu_(2)O/Cu/N-C photocatalysts demonstrate exceptional photocatalytic activity in the homo-coupling reaction of terminal alkynes under blue-light irradiation and air atmosphere.The present study presents a novel research methodology for the development of highly efficient visible light catalysts to facilitate organic reactions in future applications.展开更多
Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantiose...Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantioselective annulation of SCBs with terminal alkynes remains a challenge.Herein,we report a rhodium-catalyzed asymmetric annulation reaction of SCBs with terminal alkynes,which relies on the newly identified chiral sulfinamide phosphine ligand Ming-Phos.This catalytic system exhibits unique effects under mild conditions,leading to the direct synthesis of structurally diverse chiral silacycles in moderate to good yields with high enantioselectivities(up to 95%ee).展开更多
Mercurous chloride catalyzed Mannich condensation of terminal alkynes with secondary amines and aldehydes has been developed. The reaction generated β-aminoalkynes in good yields.
Reaction of perfluoroalkyl iodides with a series of alkynes under sulfinatodehalogenation condition gave a mixture of E/Z adducts very readily in high yield, thus constituted a mild, convenient and effective new metho...Reaction of perfluoroalkyl iodides with a series of alkynes under sulfinatodehalogenation condition gave a mixture of E/Z adducts very readily in high yield, thus constituted a mild, convenient and effective new method for the addition of perfluoroalkyl iodides to alkynes. Under the same con- dition, in the presence of 1-hexyne perfluoroalkyl bromide and 1,1,1-trichlorotrifluoroethane reacted only to give sulfinates as the major products. A radical mechanism was proposed for the addition reaction.展开更多
A novel platinum-catalyzed asymmetric ring-opening reaction of oxabenzonorbornadiene with terminal alkynes is described.The reaction affords optically active cis-2-alkynyl-1,2-dihydronaphthalen-1-ols in moderate yield...A novel platinum-catalyzed asymmetric ring-opening reaction of oxabenzonorbornadiene with terminal alkynes is described.The reaction affords optically active cis-2-alkynyl-1,2-dihydronaphthalen-1-ols in moderate yields with good enantioselectivity in the presence of catalytic amounts of Pt(COD)Cl_(2)/(S)-BINAP and an excess of zinc powder.The products were obtained exclusively with the relative cis-configuration of the ring substituents and the prevalent(1R,2S)-configuration of the stereocenters,as determined by single crystal X-ray diffraction analysis.展开更多
A facile and efficient synthesis of N-sulfonyl-N,N-disubstituted amidines has been achieved via a CuI-catalyzed three-component free-radical coupling reaction of tertiary amines and arenesulfonyl azides with terminal ...A facile and efficient synthesis of N-sulfonyl-N,N-disubstituted amidines has been achieved via a CuI-catalyzed three-component free-radical coupling reaction of tertiary amines and arenesulfonyl azides with terminal alkynes in the presence of azodiisobutyronitrile(AIBN).The reaction mechanism of this reaction has also been studied.展开更多
A microwave enhanced, solventless Mannich condensation of terminal alkynes, primary amines with paraformaldehyde on cuprous iodide doped alumina has been investigated. The structures of products depend on the ratio o...A microwave enhanced, solventless Mannich condensation of terminal alkynes, primary amines with paraformaldehyde on cuprous iodide doped alumina has been investigated. The structures of products depend on the ratio of alkyne to amine and paraformaldehyde.展开更多
FeCl3- and GaCl3-catalyzed dehydrative coupling reactions of chromone-derived Morita-Baylis-Hillman （MBH） alcohols with terminal alkynes were developed. The reactions provided exclusively a-regioselective and acetyl...FeCl3- and GaCl3-catalyzed dehydrative coupling reactions of chromone-derived Morita-Baylis-Hillman （MBH） alcohols with terminal alkynes were developed. The reactions provided exclusively a-regioselective and acetylene-substituted products in good yields.展开更多
A facile and practical synthetic route of unsymmetrical 1,3-diynes via the PdC1/CuI catalyzed oxidative coupling of two different terminal alkynes has been developed by using 3-（diphenylphosphino）propanoic acid as a...A facile and practical synthetic route of unsymmetrical 1,3-diynes via the PdC1/CuI catalyzed oxidative coupling of two different terminal alkynes has been developed by using 3-（diphenylphosphino）propanoic acid as a ligand in the presence of oxygen. This system is suitable for not only aromatic alkynes but also heteroaromatic and aliphatic alkynes which were transformed into the corresponding unsymmetrical 1,3-diynes in moderate to good yields at room temperature. Moreover, the unsymmetrical 1,3-diynes were also obtained on a multi-gram scale. Mechanistic studies suggest that oxygen plays a key role in the catalytic cycles.展开更多
基金the K.N.Toosi University of Technology Research Council for financial assistance
文摘Alkynyl selenides were prepared under very mild conditions by reacting terminal alkynes with respective diorganic diselenides in the presence of potassium t-butoxide. The advantages of this protocol include the use of readily available substrates and reagent and good yield of the products.
文摘A highly efficient and regio-/stereoselective method of hydrosilylating terminal alkynes was developed using Pt(DVDS)-tri(t-butyl) phosphine catalyst system at room temperature.Trans-products or alpha-products were obtained almost exclusively depending on the alkynes and silanes employed.
基金jointly supported by National Natural Science Foundation of China (NSFC) (Nos. 91527303, 21333001)
文摘Bottom-up approach to constructing low-dimensional nanostructures on surfaces with terminal alkynes has drawn great interest because of its potential applications in fabricating advanced functional nanomaterials. The diversity of the achieved products manifests rich chemistry of terminal alkynes and hence careful linking strategies and proper controlling methodologies are required for selective preparations of high-quality target nanoarchitectures. This review summarizes various on-surface linking strategies for terminal alkynes, including non-bonding interactions as well as organometallic and covalent bonds, and presents examples to show effective control of surface assemblies and reactions of terminal alkynes by variations of the precursor structures, substrates and activation modes. Systematic studies of the on-surface linkage of terminal alkynes may help efficient and predictable preparations of surface nanomaterials and further understanding of surface chemistry.
基金supported by the National Natural Science Foundation of China(21222203,21172226,21133011)
文摘A novel catalytic reaction has been developed for the nucleophilic addition of terminal alkynes toα,β‐unsaturated‐γ‐lactams via a cyclic N‐acyliminium ion intermediate. This simple reaction pro‐ceeds rapidly under mild conditions, and provided a practical approach for the synthesis of a wide range of 5‐alkynyl‐2‐pyrrolidinones in moderate to good yields （45%–76%）.
基金financial support from the National Natural Science Foundation of China (No. 21472033)the National Key R&D Program of China (No. 2018YFB1501604)the Fundamental Research Funds for the Central Universities (No. PA2020GDKC0021)。
文摘The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low(400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multigram scale. It is suitable for the synthesis of alkenes labeled with deuterium, and for the late-stage modification of bioactive molecules.
基金Supported by the National Natural Science Foundation of China
文摘The stereospecific carbocupration of terminal alkynes via higher order cuprates to give 1,1'-disubstituted olefins with 99% configuration purity is described. Its synthetic utility as a general method for the preparation of substituted olefins is further illustrated by the direct synthesis of (±)-ipsenol and (E)-β-farnesene with highly geometric purity of the carbon-carbon double bond.
基金supported by grants from the National Natural Science Foundation of China(Nos.21472176 and U1904212)the Natural Science Foundation of Henan Province(No.222300420294)the China Postdoctoral Science Foundation(No.2020M672260).
文摘Readily prepared chiral bis(imidazoline)NCN pincer iridium(III)complexes have been developed as the new and highly stereoselective catalysts for the direct asymmetric addition of terminal alkynes to trifluoropyruvates.With a catalyst loading of 5 mol%,a variety of optically activeα-trifluoromethylated tertiary propargylic alcohols were thus produced in good yields with high enantioselectivity(27 examples,74%–96%ee).Both enantiomers of the catalysis products were obtained by using enantiomeric Ir(III)catalysts.In addition,gram scale synthesis of the product and its transformation to a potentially very useful 2H-1,2,3-triazole compound were accomplished.Control experiments suggested that the alkynylide Ir(III)intermediates were involved in the reactions.
基金supported by the National Key R&D Program of China(2021YFF0701600,2021YFA1500200)the National Natural Science Foundation of China(22271249)+2 种基金the Zhejiang Provincial Natural Science Foundation of China(LR19B020001)the Fundamental Research Funds for the Central Universities(226-2022-00224,226-202400003)the Center of Chemistry for Frontier Technologies,Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province(PSFM 2021-05)。
文摘Transition metal-catalyzed hydrostannylation of alkynes is an atom-economic way towards valuableα-vinylstannanes.However,directing-group-free examples for the construction ofα-adducts are rare and mostly undergo the M-Sn species insertion process.Here,we report an efficient cobalt-catalyzed highlyα-selective hydrostannylation of terminal alkynes via M-H species,using readily available Bu3Sn H and easily accessible as well as bench-stable ligand.The robust catalytic system,bearing good functional group tolerance and operational simplicity,provides theα-vinylstannanes in moderate to excellent yields with≥97:3 rr averagely.The efficiency of the reaction is investigated with turnover number(TON)up to 10,000 and turnover frequency(TOF)up to 144,000 h^(-1),respectively.The synthetic utility of theα-vinylstannanes is proved by further derivatizations towards the 1,1-disubstituted alkenes via Kosugi-Migita-Stille cross-coupling,conjugated alkene,α-vinyliodine,α-vinylazide,and allyl alcohol.Several control experiments,deuterium-labeling experiment and density functional theory(DFT)calculations are conducted to reveal the preliminary mechanism.
基金supported by Peking University,the National Natural Science Foundation of China(20872003)National Basic Research Program of China(973 program)(2009CB825300)
文摘Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign.Iron-mediated sp-sp3 C-C bond formation through the cross dehydrogenative coupling(CDC) of terminal alkynes with benzylic ethers or alkanes has been developed.The inexpensive iron salt is used as the catalyst to make this transformation environmentally benign.
基金supported by the National Natural Science Foundation of China(21878072,21706058,22102062,21725602)the Hunan Provincial Natural Science Foundation of China(2020JJ2011)the China Postdoctoral Science Foundation(2019M662774).
文摘The cross-dimerization of terminal alkynes is the most straightforward and attractive approach to differently substituted 1,3-enynes,which are vital structural motifs in natural products,biologically active compounds,and organic functional materials,etc.However,due to the inherent issues of the stereo-,regio-,and chemoselectivity,the strategy is less explored and remains problematic in substrate scope,selectivity,and screening of catalytic system,etc.Herein,a specific cross-dimerization of terminal alkynes is developed under Pd/TMEDA catalysis,which produces a series of gem-1,3-enynes(58 examples)in totally moderate to high yields with outstanding functional group tolerance.A cyclopalladium compound might be the key imtermediate,which performs anti-addition-carbometallation,and leads to the exclusive cross-selectivity.The unprecedented features of the reaction,such as anti-addition-carbometallation,easy control of selectivity,wide range of the donor alkynes,and very simple catalytic conditions,allow it not only a facile and functionally diverse synthesis of 1,3-enynes,but also a substantial progress for the textbook reaction.
基金supported by the Xuzhou Key Research and Development Program(Social Development)(No.KC23298)the National Natural Science Foundation of China(No.22271122)+1 种基金the Natural Science Foundation of Jiangsu Province(No.BK20211549)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX23_2903).
文摘The efficient utilization of visible light catalysts for organic reactions necessitates not only the effective separation of photogenerated electrons and holes to participate in the reaction,but also their ability to form key intermediates with reactant molecules.The present study successfully synthesized a crusiform-like mesoporous structure of nitrogen-doped carbon-coated Cu_(2)O/Cu(Cu_(2)O/Cu/N-C)with a Cu_(2)O/dual electron acceptor interface using etched HKUST-1 as the precursor.A series of theoretical and experimental studies have demonstrated that the Cu_(2)O/Cu/N-C interface in the photocatalytic homo-coupling of terminal alkynes not only effectively enhances the separation of photogenerated electron−hole pairs,but also facilitates the formation of the key intermediate[Cu_(2)O/Cu/N-C]-phenylacetylide and promotes the rearrangement of its internal charges.As a result,the homo-coupling reaction can be effectively facilitated.The primary reason for the functional role of Cu_(2)O/Cu/N-C interface lies in the downward bending of energy band from Cu_(2)O to N-doped C layers,induced by the different work functions of Cu_(2)O,Cu and N-doped C layers.Consequently,Cu_(2)O/Cu/N-C photocatalysts demonstrate exceptional photocatalytic activity in the homo-coupling reaction of terminal alkynes under blue-light irradiation and air atmosphere.The present study presents a novel research methodology for the development of highly efficient visible light catalysts to facilitate organic reactions in future applications.
基金the funding support of the National Key R&D Program of China(No.2021YFF0701601)NSFC(Nos.22031004 and 21921003)+1 种基金Shanghai Municipal Education Commission(No.20212308)Science and Technology Commission of Shanghai Municipality(No.23ZR1404800).
文摘Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantioselective annulation of SCBs with terminal alkynes remains a challenge.Herein,we report a rhodium-catalyzed asymmetric annulation reaction of SCBs with terminal alkynes,which relies on the newly identified chiral sulfinamide phosphine ligand Ming-Phos.This catalytic system exhibits unique effects under mild conditions,leading to the direct synthesis of structurally diverse chiral silacycles in moderate to good yields with high enantioselectivities(up to 95%ee).
基金Project supported by the National Natural Science Foundation of China （No. 20372024）, the Excellent Scientist Foundation of Anhui Province （No.04046080）, the Natural Science Foundation of the Education Department of Anhui Province （No. 2002kj254zd）, the Scientific Research Foundation for the Returned 0verseas Chinese Scholars, the Ministry of Education of China （No. 2002247）, the Excellent Young Teacher Program of the Ministry of Education of China （No. 2024） and the Key Project of Science and Technology of the Ministry of Education of China （No. 0204069）.
文摘Mercurous chloride catalyzed Mannich condensation of terminal alkynes with secondary amines and aldehydes has been developed. The reaction generated β-aminoalkynes in good yields.
文摘Reaction of perfluoroalkyl iodides with a series of alkynes under sulfinatodehalogenation condition gave a mixture of E/Z adducts very readily in high yield, thus constituted a mild, convenient and effective new method for the addition of perfluoroalkyl iodides to alkynes. Under the same con- dition, in the presence of 1-hexyne perfluoroalkyl bromide and 1,1,1-trichlorotrifluoroethane reacted only to give sulfinates as the major products. A radical mechanism was proposed for the addition reaction.
基金the National Natural Science Foundation of China(No.41376149)the Guangzhou Pearl River New Star Plan of Science and Technology Program(No.2012J2200015).
文摘A novel platinum-catalyzed asymmetric ring-opening reaction of oxabenzonorbornadiene with terminal alkynes is described.The reaction affords optically active cis-2-alkynyl-1,2-dihydronaphthalen-1-ols in moderate yields with good enantioselectivity in the presence of catalytic amounts of Pt(COD)Cl_(2)/(S)-BINAP and an excess of zinc powder.The products were obtained exclusively with the relative cis-configuration of the ring substituents and the prevalent(1R,2S)-configuration of the stereocenters,as determined by single crystal X-ray diffraction analysis.
基金National Natural Science Foundation of China (20872001)the Anhui Education Department (TD200707 & KJ2008A064)+1 种基金the Program for the NCET (NCET-10-0004)the Research Culture Funds of Anhui Normal University (2010rcpy041) for their financial support
文摘A facile and efficient synthesis of N-sulfonyl-N,N-disubstituted amidines has been achieved via a CuI-catalyzed three-component free-radical coupling reaction of tertiary amines and arenesulfonyl azides with terminal alkynes in the presence of azodiisobutyronitrile(AIBN).The reaction mechanism of this reaction has also been studied.
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 172 0 18) theExcellentScientistFoundationofAnhuiProvince (No .2 0 0 10 40 ) +1 种基金theNaturalScienceFoundationoftheEducationDepartmentofAnhuiProvince (No .2 0 0 2kj2 5 4ZD) theSci e
文摘A microwave enhanced, solventless Mannich condensation of terminal alkynes, primary amines with paraformaldehyde on cuprous iodide doped alumina has been investigated. The structures of products depend on the ratio of alkyne to amine and paraformaldehyde.
基金Project supported by the National Natural Science Foundation of China, Ministry of Science and Technology （973 Program, No. 2011CB808600） and the Chinese Academy of Sciences.
文摘FeCl3- and GaCl3-catalyzed dehydrative coupling reactions of chromone-derived Morita-Baylis-Hillman （MBH） alcohols with terminal alkynes were developed. The reactions provided exclusively a-regioselective and acetylene-substituted products in good yields.
基金We gratefully acknowledge the financial support of this work by the National Natural Science Foundation of China （Nos. 21563025, 21463022）, Shihezi University Training Programme for Distinguished Youth Scholars （No. 2014ZRKXJQ05）, and Start-Up Foundation for Young Scientists of Shihezi University （No. RCZX201408）.
文摘A facile and practical synthetic route of unsymmetrical 1,3-diynes via the PdC1/CuI catalyzed oxidative coupling of two different terminal alkynes has been developed by using 3-（diphenylphosphino）propanoic acid as a ligand in the presence of oxygen. This system is suitable for not only aromatic alkynes but also heteroaromatic and aliphatic alkynes which were transformed into the corresponding unsymmetrical 1,3-diynes in moderate to good yields at room temperature. Moreover, the unsymmetrical 1,3-diynes were also obtained on a multi-gram scale. Mechanistic studies suggest that oxygen plays a key role in the catalytic cycles.
