The multiple roles of the tumor necrosis factor(TNF)-α-inducible protein 8(TNFAIP8),also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and ap...The multiple roles of the tumor necrosis factor(TNF)-α-inducible protein 8(TNFAIP8),also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis.In this review,we found that the TIPE family showed highly homologous sequences and conserved functional domains,such as the death effector domain(DED)-like domain but displayed different roles and mechanisms in different biological activities.For example,while TIPE is primarily associated with tumor progression and antitumor drug resistance,TIPE1 suppresses tumor progression in most instances.TIPE2 has multiple roles in tumor progression regulation,and antitumor drug resistance.Moreover,TIPE2 was also involved in inflammatory response regulation,tumor typing,and staging.A few studies reported that TIPE3 was engaged in tumor development by activating the phosphatidylinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling pathway.The structure,function,and mechanism of the TIPE family in cancer and inflammation have been summarized in this review.This might serve as a reference for further research on the TIPE family and shed new light on the crosstalk among antitumor responses,inflammation,and immunology.展开更多
TIPE(Tumor necrosis factor-alpha-induced protein 8-like)家族是新近报道的免疫和肿瘤调节因子。该家族拥有四个高度同源的成员:TNFAIP8(Tumor necrosis factor-α-induced protein 8),TIPE1(TNFAIP8L1),TIPE2(TNFAIP8L2)和TIPE3(TNF...TIPE(Tumor necrosis factor-alpha-induced protein 8-like)家族是新近报道的免疫和肿瘤调节因子。该家族拥有四个高度同源的成员:TNFAIP8(Tumor necrosis factor-α-induced protein 8),TIPE1(TNFAIP8L1),TIPE2(TNFAIP8L2)和TIPE3(TNFAIP8L3)。它们虽然结构相似,但在组织、器官上的表达不同,在生物学功能及疾病中的作用存在较大的差别。TNFAIP8具有抑制细菌感染与促肿瘤迁移的作用;TIPE2是一种免疫和炎症负调控因子,可抑制某些肿瘤的生长;TIPE1可诱导细胞凋亡具有抑瘤效应;TIPE3可特异性结合磷脂第二信使,促进肿瘤生成。随着研究的深入,TIPE家族在多种疾病的发生发展过程中表现出重要的调控作用,然而其具体生物活性与分子机制有待进一步的研究。展开更多
基金supported by the Medical Scientific Research Foundation of Guangdong Province of China(No.A2021236)2022 Guangdong Provincial Education Science Planning Project(Higher Education Special Project,No.2022GXJK221)+4 种基金the 2021 Open Project Fund of Guangdong Provincial Key Laboratory of Medicinal Functional Gene Research,the National Key Clinical Specialty Construction Project(Clinical Pharmacy)and High-Level Clinical Key Specialty(Clinical Pharmacy)in Guangdong Province,Science and Technology Program of Guangzhou,China(No.202201010154)the Special Fund for the Cultivation of Scientific and Technological Innovation of College Students in Guangdong Province of China(No.pdjh2022b0270)the College Students’Innovation and Entrepreneurship Training Project of Guangdong Province(Nos.202210573054,202210573041)Special Fund for the Cultivation of National Natural Science Foundation of China in School of Clinical Pharmacy,Guangdong Pharmaceutical University(No.SCP2022-03)Jinghua(Zhejiang Province)Science and Technology Research Program Project(No.2021-4-135).
文摘The multiple roles of the tumor necrosis factor(TNF)-α-inducible protein 8(TNFAIP8),also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis.In this review,we found that the TIPE family showed highly homologous sequences and conserved functional domains,such as the death effector domain(DED)-like domain but displayed different roles and mechanisms in different biological activities.For example,while TIPE is primarily associated with tumor progression and antitumor drug resistance,TIPE1 suppresses tumor progression in most instances.TIPE2 has multiple roles in tumor progression regulation,and antitumor drug resistance.Moreover,TIPE2 was also involved in inflammatory response regulation,tumor typing,and staging.A few studies reported that TIPE3 was engaged in tumor development by activating the phosphatidylinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling pathway.The structure,function,and mechanism of the TIPE family in cancer and inflammation have been summarized in this review.This might serve as a reference for further research on the TIPE family and shed new light on the crosstalk among antitumor responses,inflammation,and immunology.
文摘TIPE(Tumor necrosis factor-alpha-induced protein 8-like)家族是新近报道的免疫和肿瘤调节因子。该家族拥有四个高度同源的成员:TNFAIP8(Tumor necrosis factor-α-induced protein 8),TIPE1(TNFAIP8L1),TIPE2(TNFAIP8L2)和TIPE3(TNFAIP8L3)。它们虽然结构相似,但在组织、器官上的表达不同,在生物学功能及疾病中的作用存在较大的差别。TNFAIP8具有抑制细菌感染与促肿瘤迁移的作用;TIPE2是一种免疫和炎症负调控因子,可抑制某些肿瘤的生长;TIPE1可诱导细胞凋亡具有抑瘤效应;TIPE3可特异性结合磷脂第二信使,促进肿瘤生成。随着研究的深入,TIPE家族在多种疾病的发生发展过程中表现出重要的调控作用,然而其具体生物活性与分子机制有待进一步的研究。
