BACKGROUND Thyroid cartilage noncontiguous metastatic involvement is an extremely rare entity due to the absence of vessels within the cartilaginous tissue.A literature review revealed that metastasis from lung cancer...BACKGROUND Thyroid cartilage noncontiguous metastatic involvement is an extremely rare entity due to the absence of vessels within the cartilaginous tissue.A literature review revealed that metastasis from lung cancer is even rarer.CASE SUMMARY A 51-year-old male smoker presented with progressive,painful left upper neck lumps for 8 months,accompanied by 10 kg weight loss,poor appetite,and mentation.He had a 30-year history of chronic alcohol use.Following compre-hensive imaging studies and pathological examinations,we have identified metastatic lung adenocarcinoma with widespread dissemination to multiple sites including the thyroid cartilage.The final diagnosis is:Lung adenocarcinoma(pT3N3M1c,Stage IVb),epidermal growth factor receptor-mutated(p.E746_S752 delinsV).After multidisciplinary team discussion,the patient was initiated on targeted therapy with gefitinib(250 mg/day).At 6-month follow-up,the patient has shown significant clinical improvement with marked reduction in subcutaneous masses in both the cervical and abdominal regions.CONCLUSION Monitor for uncommon thyroid cartilage noncontiguous metastases;early detection improves outcomes.展开更多
基金Supported by Science and Technology Projects in Guangzhou,No.2024A03J0563 and No.2023A03J0521.
文摘BACKGROUND Thyroid cartilage noncontiguous metastatic involvement is an extremely rare entity due to the absence of vessels within the cartilaginous tissue.A literature review revealed that metastasis from lung cancer is even rarer.CASE SUMMARY A 51-year-old male smoker presented with progressive,painful left upper neck lumps for 8 months,accompanied by 10 kg weight loss,poor appetite,and mentation.He had a 30-year history of chronic alcohol use.Following compre-hensive imaging studies and pathological examinations,we have identified metastatic lung adenocarcinoma with widespread dissemination to multiple sites including the thyroid cartilage.The final diagnosis is:Lung adenocarcinoma(pT3N3M1c,Stage IVb),epidermal growth factor receptor-mutated(p.E746_S752 delinsV).After multidisciplinary team discussion,the patient was initiated on targeted therapy with gefitinib(250 mg/day).At 6-month follow-up,the patient has shown significant clinical improvement with marked reduction in subcutaneous masses in both the cervical and abdominal regions.CONCLUSION Monitor for uncommon thyroid cartilage noncontiguous metastases;early detection improves outcomes.
