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Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network 被引量:1
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作者 Yu Zhang Daoyu Zhang TiezhouWu 《Energy Engineering》 EI 2025年第1期203-220,共18页
Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,curr... Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery systems.However,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity degradation.Additionally,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model performance.To address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural network.Firstly,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity curves.Next,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network model.To validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging dataset.The experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%. 展开更多
关键词 Lithium-ion battery state of health differential thermal voltammetry Sparrow Search algorithm
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Robustness Optimization Algorithm with Multi-Granularity Integration for Scale-Free Networks Against Malicious Attacks 被引量:1
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作者 ZHANG Yiheng LI Jinhai 《昆明理工大学学报(自然科学版)》 北大核心 2025年第1期54-71,共18页
Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently... Complex network models are frequently employed for simulating and studyingdiverse real-world complex systems.Among these models,scale-free networks typically exhibit greater fragility to malicious attacks.Consequently,enhancing the robustness of scale-free networks has become a pressing issue.To address this problem,this paper proposes a Multi-Granularity Integration Algorithm(MGIA),which aims to improve the robustness of scale-free networks while keeping the initial degree of each node unchanged,ensuring network connectivity and avoiding the generation of multiple edges.The algorithm generates a multi-granularity structure from the initial network to be optimized,then uses different optimization strategies to optimize the networks at various granular layers in this structure,and finally realizes the information exchange between different granular layers,thereby further enhancing the optimization effect.We propose new network refresh,crossover,and mutation operators to ensure that the optimized network satisfies the given constraints.Meanwhile,we propose new network similarity and network dissimilarity evaluation metrics to improve the effectiveness of the optimization operators in the algorithm.In the experiments,the MGIA enhances the robustness of the scale-free network by 67.6%.This improvement is approximately 17.2%higher than the optimization effects achieved by eight currently existing complex network robustness optimization algorithms. 展开更多
关键词 complex network model MULtI-GRANULARItY scale-free networks ROBUStNESS algorithm integration
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Short-TermWind Power Forecast Based on STL-IAOA-iTransformer Algorithm:A Case Study in Northwest China 被引量:2
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作者 Zhaowei Yang Bo Yang +5 位作者 Wenqi Liu Miwei Li Jiarong Wang Lin Jiang Yiyan Sang Zhenning Pan 《Energy Engineering》 2025年第2期405-430,共26页
Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids.Although numerous studies have employed various methods to forecast wind power,th... Accurate short-term wind power forecast technique plays a crucial role in maintaining the safety and economic efficiency of smart grids.Although numerous studies have employed various methods to forecast wind power,there remains a research gap in leveraging swarm intelligence algorithms to optimize the hyperparameters of the Transformer model for wind power prediction.To improve the accuracy of short-term wind power forecast,this paper proposes a hybrid short-term wind power forecast approach named STL-IAOA-iTransformer,which is based on seasonal and trend decomposition using LOESS(STL)and iTransformer model optimized by improved arithmetic optimization algorithm(IAOA).First,to fully extract the power data features,STL is used to decompose the original data into components with less redundant information.The extracted components as well as the weather data are then input into iTransformer for short-term wind power forecast.The final predicted short-term wind power curve is obtained by combining the predicted components.To improve the model accuracy,IAOA is employed to optimize the hyperparameters of iTransformer.The proposed approach is validated using real-generation data from different seasons and different power stations inNorthwest China,and ablation experiments have been conducted.Furthermore,to validate the superiority of the proposed approach under different wind characteristics,real power generation data fromsouthwestChina are utilized for experiments.Thecomparative results with the other six state-of-the-art prediction models in experiments show that the proposed model well fits the true value of generation series and achieves high prediction accuracy. 展开更多
关键词 Short-termwind power forecast improved arithmetic optimization algorithm itransformer algorithm SimuNPS
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基于改进POT模型的土石坝渗流监控指标拟定方法
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作者 周扬 李初寅 +1 位作者 庞锐 徐斌 《大连理工大学学报》 北大核心 2026年第1期103-110,共8页
针对现有土石坝渗流监控指标拟定方法存在主观性较强和精度较低的不足,基于智能算法改进的超阈值(peaks over threshold,POT)模型,提出了优化的土石坝渗流监控指标拟定方法.以3σ准则为确定最优阈值的理论基础,采用基于混沌映射、结合L... 针对现有土石坝渗流监控指标拟定方法存在主观性较强和精度较低的不足,基于智能算法改进的超阈值(peaks over threshold,POT)模型,提出了优化的土石坝渗流监控指标拟定方法.以3σ准则为确定最优阈值的理论基础,采用基于混沌映射、结合Levy飞行和逆向学习的动态选择策略改进的麻雀搜索算法(improved chaos sparrow search algorithm,ICSSA),对POT模型中阈值的选取方法进行优化.建立了ICSSA-POT模型,实现对监测资料尾部数据的拟合,从而得到更为合理的土石坝渗流监控指标.研究表明,相比于传统方法,所提方法可有效避免主观性与随机误差,得到的监测资料尾部数据的拟合决定系数提高了5%,具有更高的计算精度,拟定的渗流监控指标更偏于安全,对防范土石坝渗流破坏、确保土石坝安全长效运行具有较强的指导意义. 展开更多
关键词 土石坝 渗流监测 POt模型 麻雀搜索算法 参数优化
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百合固金汤联合莫西沙星对耐多药肺结核肺肾阴虚证患者T淋巴细胞亚群及中医证候积分的影响
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作者 潘静洁 刘堂营 +2 位作者 黄晋 黄婷婷 陈亮 《当代医药论丛》 2026年第1期141-144,共4页
目的:探讨百合固金汤联合莫西沙星对耐多药肺结核肺肾阴虚证患者的治疗效果。方法:以随机数字表法将2022年4月—2025年1月广州市胸科医院收治的86例耐多药肺结核肺肾阴虚证患者分为两组,对照组(43例)予以莫西沙星治疗,在对照组基础上为... 目的:探讨百合固金汤联合莫西沙星对耐多药肺结核肺肾阴虚证患者的治疗效果。方法:以随机数字表法将2022年4月—2025年1月广州市胸科医院收治的86例耐多药肺结核肺肾阴虚证患者分为两组,对照组(43例)予以莫西沙星治疗,在对照组基础上为观察组(43例)加用百合固金汤治疗。对比两组临床疗效、中医证候积分、血清T淋巴细胞亚群水平及不良反应发生率。结果:观察组总有效率为93.02%,对照组总有效率为74.42%,组间对比,观察组更高(P<0.05);观察组治疗后的中医证候积分低于对照组,血清T淋巴细胞亚群水平优于对照组(P<0.05);两组不良反应发生率对比,差异无统计学意义(P > 0.05)。结论:百合固金汤联合莫西沙星治疗耐多药肺结核肺肾阴虚证,可有效改善患者的临床症状,调节其血清T淋巴细胞亚群水平,提高免疫功能,且不会增加不良反应。 展开更多
关键词 耐多药肺结核 肺肾阴虚证 莫西沙星 百合固金汤 t淋巴细胞亚群
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A LODBO algorithm for multi-UAV search and rescue path planning in disaster areas 被引量:1
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作者 Liman Yang Xiangyu Zhang +2 位作者 Zhiping Li Lei Li Yan Shi 《Chinese Journal of Aeronautics》 2025年第2期200-213,共14页
In disaster relief operations,multiple UAVs can be used to search for trapped people.In recent years,many researchers have proposed machine le arning-based algorithms,sampling-based algorithms,and heuristic algorithms... In disaster relief operations,multiple UAVs can be used to search for trapped people.In recent years,many researchers have proposed machine le arning-based algorithms,sampling-based algorithms,and heuristic algorithms to solve the problem of multi-UAV path planning.The Dung Beetle Optimization(DBO)algorithm has been widely applied due to its diverse search patterns in the above algorithms.However,the update strategies for the rolling and thieving dung beetles of the DBO algorithm are overly simplistic,potentially leading to an inability to fully explore the search space and a tendency to converge to local optima,thereby not guaranteeing the discovery of the optimal path.To address these issues,we propose an improved DBO algorithm guided by the Landmark Operator(LODBO).Specifically,we first use tent mapping to update the population strategy,which enables the algorithm to generate initial solutions with enhanced diversity within the search space.Second,we expand the search range of the rolling ball dung beetle by using the landmark factor.Finally,by using the adaptive factor that changes with the number of iterations.,we improve the global search ability of the stealing dung beetle,making it more likely to escape from local optima.To verify the effectiveness of the proposed method,extensive simulation experiments are conducted,and the result shows that the LODBO algorithm can obtain the optimal path using the shortest time compared with the Genetic Algorithm(GA),the Gray Wolf Optimizer(GWO),the Whale Optimization Algorithm(WOA)and the original DBO algorithm in the disaster search and rescue task set. 展开更多
关键词 Unmanned aerial vehicle Path planning Meta heuristic algorithm DBO algorithm NP-hard problems
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基于三维集成的Ku波段双面引出高功率T/R模块
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作者 程玺琮 周彪 +1 位作者 许向前 王子杰 《半导体技术》 北大核心 2026年第1期57-62,76,共7页
面向低剖面有源相控阵天线系统,基于三维集成技术研制了一款Ku波段双面引出四通道高功率收发(T/R)模块。模块通过多功能芯片集成技术实现大功率、高密度单层瓦式集成;设计了类同轴垂直互连结构,可通过球栅阵列实现双面对外信号互连,解... 面向低剖面有源相控阵天线系统,基于三维集成技术研制了一款Ku波段双面引出四通道高功率收发(T/R)模块。模块通过多功能芯片集成技术实现大功率、高密度单层瓦式集成;设计了类同轴垂直互连结构,可通过球栅阵列实现双面对外信号互连,解决了当前模块仅能单面互连的问题,并对关键结构进行电路分析及电磁仿真;为确保高输出功率工作,进行了散热设计和仿真验证。测试结果表明,在Ku波段发射通道饱和输出功率大于40 dBm,接收通道增益大于25 dB,噪声系数小于3.5 dB,模块尺寸仅为16.0 mm×16.0 mm×2.2 mm。 展开更多
关键词 收发(t/R)模块 KU波段 双面引出 高功率 三维集成
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Research on Euclidean Algorithm and Reection on Its Teaching
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作者 ZHANG Shaohua 《应用数学》 北大核心 2025年第1期308-310,共3页
In this paper,we prove that Euclid's algorithm,Bezout's equation and Divi-sion algorithm are equivalent to each other.Our result shows that Euclid has preliminarily established the theory of divisibility and t... In this paper,we prove that Euclid's algorithm,Bezout's equation and Divi-sion algorithm are equivalent to each other.Our result shows that Euclid has preliminarily established the theory of divisibility and the greatest common divisor.We further provided several suggestions for teaching. 展开更多
关键词 Euclid's algorithm Division algorithm Bezout's equation
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DDoS Attack Autonomous Detection Model Based on Multi-Strategy Integrate Zebra Optimization Algorithm
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作者 Chunhui Li Xiaoying Wang +2 位作者 Qingjie Zhang Jiaye Liang Aijing Zhang 《Computers, Materials & Continua》 SCIE EI 2025年第1期645-674,共30页
Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convol... Previous studies have shown that deep learning is very effective in detecting known attacks.However,when facing unknown attacks,models such as Deep Neural Networks(DNN)combined with Long Short-Term Memory(LSTM),Convolutional Neural Networks(CNN)combined with LSTM,and so on are built by simple stacking,which has the problems of feature loss,low efficiency,and low accuracy.Therefore,this paper proposes an autonomous detectionmodel for Distributed Denial of Service attacks,Multi-Scale Convolutional Neural Network-Bidirectional Gated Recurrent Units-Single Headed Attention(MSCNN-BiGRU-SHA),which is based on a Multistrategy Integrated Zebra Optimization Algorithm(MI-ZOA).The model undergoes training and testing with the CICDDoS2019 dataset,and its performance is evaluated on a new GINKS2023 dataset.The hyperparameters for Conv_filter and GRU_unit are optimized using the Multi-strategy Integrated Zebra Optimization Algorithm(MIZOA).The experimental results show that the test accuracy of the MSCNN-BiGRU-SHA model based on the MIZOA proposed in this paper is as high as 0.9971 in the CICDDoS 2019 dataset.The evaluation accuracy of the new dataset GINKS2023 created in this paper is 0.9386.Compared to the MSCNN-BiGRU-SHA model based on the Zebra Optimization Algorithm(ZOA),the detection accuracy on the GINKS2023 dataset has improved by 5.81%,precisionhas increasedby 1.35%,the recallhas improvedby 9%,and theF1scorehas increasedby 5.55%.Compared to the MSCNN-BiGRU-SHA models developed using Grid Search,Random Search,and Bayesian Optimization,the MSCNN-BiGRU-SHA model optimized with the MI-ZOA exhibits better performance in terms of accuracy,precision,recall,and F1 score. 展开更多
关键词 Distributed denial of service attack intrusion detection deep learning zebra optimization algorithm multi-strategy integrated zebra optimization algorithm
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Bearing capacity prediction of open caissons in two-layered clays using five tree-based machine learning algorithms 被引量:1
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作者 Rungroad Suppakul Kongtawan Sangjinda +3 位作者 Wittaya Jitchaijaroen Natakorn Phuksuksakul Suraparb Keawsawasvong Peem Nuaklong 《Intelligent Geoengineering》 2025年第2期55-65,共11页
Open caissons are widely used in foundation engineering because of their load-bearing efficiency and adaptability in diverse soil conditions.However,accurately predicting their undrained bearing capacity in layered so... Open caissons are widely used in foundation engineering because of their load-bearing efficiency and adaptability in diverse soil conditions.However,accurately predicting their undrained bearing capacity in layered soils remains a complex challenge.This study presents a novel application of five ensemble machine(ML)algorithms-random forest(RF),gradient boosting machine(GBM),extreme gradient boosting(XGBoost),adaptive boosting(AdaBoost),and categorical boosting(CatBoost)-to predict the undrained bearing capacity factor(Nc)of circular open caissons embedded in two-layered clay on the basis of results from finite element limit analysis(FELA).The input dataset consists of 1188 numerical simulations using the Tresca failure criterion,varying in geometrical and soil parameters.The FELA was performed via OptumG2 software with adaptive meshing techniques and verified against existing benchmark studies.The ML models were trained on 70% of the dataset and tested on the remaining 30%.Their performance was evaluated using six statistical metrics:coefficient of determination(R²),mean absolute error(MAE),root mean squared error(RMSE),index of scatter(IOS),RMSE-to-standard deviation ratio(RSR),and variance explained factor(VAF).The results indicate that all the models achieved high accuracy,with R²values exceeding 97.6%and RMSE values below 0.02.Among them,AdaBoost and CatBoost consistently outperformed the other methods across both the training and testing datasets,demonstrating superior generalizability and robustness.The proposed ML framework offers an efficient,accurate,and data-driven alternative to traditional methods for estimating caisson capacity in stratified soils.This approach can aid in reducing computational costs while improving reliability in the early stages of foundation design. 展开更多
关键词 two-layered clay Open caisson tree-based algorithms FELA Machine learning
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Path Planning for Thermal Power Plant Fan Inspection Robot Based on Improved A^(*)Algorithm 被引量:1
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作者 Wei Zhang Tingfeng Zhang 《Journal of Electronic Research and Application》 2025年第1期233-239,共7页
To improve the efficiency and accuracy of path planning for fan inspection tasks in thermal power plants,this paper proposes an intelligent inspection robot path planning scheme based on an improved A^(*)algorithm.The... To improve the efficiency and accuracy of path planning for fan inspection tasks in thermal power plants,this paper proposes an intelligent inspection robot path planning scheme based on an improved A^(*)algorithm.The inspection robot utilizes multiple sensors to monitor key parameters of the fans,such as vibration,noise,and bearing temperature,and upload the data to the monitoring center.The robot’s inspection path employs the improved A^(*)algorithm,incorporating obstacle penalty terms,path reconstruction,and smoothing optimization techniques,thereby achieving optimal path planning for the inspection robot in complex environments.Simulation results demonstrate that the improved A^(*)algorithm significantly outperforms the traditional A^(*)algorithm in terms of total path distance,smoothness,and detour rate,effectively improving the execution efficiency of inspection tasks. 展开更多
关键词 Power plant fans Inspection robot Path planning Improved A^(*)algorithm
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Rapid pathologic grading-based diagnosis of esophageal squamous cell carcinoma via Raman spectroscopy and a deep learning algorithm 被引量:1
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作者 Xin-Ying Yu Jian Chen +2 位作者 Lian-Yu Li Feng-En Chen Qiang He 《World Journal of Gastroenterology》 2025年第14期32-46,共15页
BACKGROUND Esophageal squamous cell carcinoma is a major histological subtype of esophageal cancer.Many molecular genetic changes are associated with its occurrence.Raman spectroscopy has become a new method for the e... BACKGROUND Esophageal squamous cell carcinoma is a major histological subtype of esophageal cancer.Many molecular genetic changes are associated with its occurrence.Raman spectroscopy has become a new method for the early diagnosis of tumors because it can reflect the structures of substances and their changes at the molecular level.AIM To detect alterations in Raman spectral information across different stages of esophageal neoplasia.METHODS Different grades of esophageal lesions were collected,and a total of 360 groups of Raman spectrum data were collected.A 1D-transformer network model was proposed to handle the task of classifying the spectral data of esophageal squamous cell carcinoma.In addition,a deep learning model was applied to visualize the Raman spectral data and interpret their molecular characteristics.RESULTS A comparison among Raman spectral data with different pathological grades and a visual analysis revealed that the Raman peaks with significant differences were concentrated mainly at 1095 cm^(-1)(DNA,symmetric PO,and stretching vibration),1132 cm^(-1)(cytochrome c),1171 cm^(-1)(acetoacetate),1216 cm^(-1)(amide III),and 1315 cm^(-1)(glycerol).A comparison among the training results of different models revealed that the 1Dtransformer network performed best.A 93.30%accuracy value,a 96.65%specificity value,a 93.30%sensitivity value,and a 93.17%F1 score were achieved.CONCLUSION Raman spectroscopy revealed significantly different waveforms for the different stages of esophageal neoplasia.The combination of Raman spectroscopy and deep learning methods could significantly improve the accuracy of classification. 展开更多
关键词 Raman spectroscopy Esophageal neoplasia Early diagnosis Deep learning algorithm Rapid pathologic grading
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An Algorithm for Cloud-based Web Service Combination Optimization Through Plant Growth Simulation
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作者 Li Qiang Qin Huawei +1 位作者 Qiao Bingqin Wu Ruifang 《系统仿真学报》 北大核心 2025年第2期462-473,共12页
In order to improve the efficiency of cloud-based web services,an improved plant growth simulation algorithm scheduling model.This model first used mathematical methods to describe the relationships between cloud-base... In order to improve the efficiency of cloud-based web services,an improved plant growth simulation algorithm scheduling model.This model first used mathematical methods to describe the relationships between cloud-based web services and the constraints of system resources.Then,a light-induced plant growth simulation algorithm was established.The performance of the algorithm was compared through several plant types,and the best plant model was selected as the setting for the system.Experimental results show that when the number of test cloud-based web services reaches 2048,the model being 2.14 times faster than PSO,2.8 times faster than the ant colony algorithm,2.9 times faster than the bee colony algorithm,and a remarkable 8.38 times faster than the genetic algorithm. 展开更多
关键词 cloud-based service scheduling algorithm resource constraint load optimization cloud computing plant growth simulation algorithm
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组蛋白去乙酰化酶抑制剂联合维奈克拉和阿扎胞苷治疗成人急性T淋巴细胞白血病的疗效及安全性研究
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作者 付积艺 郑博月 +2 位作者 吴佳霏 王珺 李慧 《中国全科医学》 北大核心 2026年第4期483-489,524,共8页
背景急性T淋巴细胞白血病(T-ALL)易产生原发耐药、诱导失败、中枢浸润、早期复发等,目前传统化疗方案缓解率低、复发率高、不良反应发生率高,成人T-ALL患者总体预后差、远期生存率低。目的采用靶向表观遗传通路的联合方案[DNA甲基转移... 背景急性T淋巴细胞白血病(T-ALL)易产生原发耐药、诱导失败、中枢浸润、早期复发等,目前传统化疗方案缓解率低、复发率高、不良反应发生率高,成人T-ALL患者总体预后差、远期生存率低。目的采用靶向表观遗传通路的联合方案[DNA甲基转移酶抑制剂阿扎胞苷+组蛋白去乙酰化酶(HDAC)抑制剂]与凋亡通路抑制剂维奈克拉,通过多靶点协同作用治疗T-ALL患者,评估HDAC抑制剂联合维奈克拉及阿扎胞苷在T-ALL患者中的疗效与安全性。方法本研究是一项探索性、单中心、单臂研究,纳入2023年6月—2025年1月四川省人民医院血液科收治的12例T-ALL患者为研究对象,收集患者的基线资料(临床特征及分子遗传学特征),患者均接受HDAC抑制剂、阿扎胞苷、维奈克拉及地塞米松联合治疗,每半月为1个疗程。治疗1~2个疗程后进行疗效评估,并通过门诊复查、住院复查、电话随访或病历系统随访完成患者随访。根据患者白血病分型分为早期前体T淋巴母细胞白血病(ETP)组、非早期前体T淋巴母细胞白血病(non-ETP)组,记录完全缓解(CR)率、总反应率(ORR)、微小残留病(MRD)阴性率、总生存率(OS)、无事件生存期(EFS),并进行亚组间分析;采用Kaplan-Meier法绘制患者生存曲线,Log-rank检验进行比较。采用单因素Cox回归分析探讨T-ALL患者预后相关因素。记录患者不良事件发生情况。结果治疗1个疗程后,12例患者中ORR为83.3%(10/12),其中CR为5例(41.7%),MRD阴性为2例(16.7%)。治疗2个疗程后,12例患者中ORR为91.7%(11/12),MRD阴性为8例(66.7%)。7例患者在接受2或3个疗程化疗后成功桥接骨髓移植,移植后目前患者全部存活。3例患者因自行停药死亡。中位随访时间为6.5(2.0,22.0)个月,中位OS及中位EFS均未达到。ETP组、non-ETP组临床疗效相比差异无统计学意义(P>0.05)。Logrank检验结果显示ETP组预后较non-ETP组更差(χ^(2)=4.830,P=0.028);移植患者预后较未移植患者更好(χ^(2)=6.545,P=0.011)。2个疗程治疗后CR患者预后较未达CR患者更好(χ^(2)=4.571,P=0.033);MRD阴性患者预后较未达MRD阴性患者更好(χ^(2)=4.571,P=0.033)。骨髓原始细胞占比>50%与<50%患者预后情况比较,差异无统计学意义(χ^(2)=0.171,P=0.67)。单因素Cox分析结果显示,性别、年龄、T-ALL类型、突变基因数量、染色体核型、疗效、MRD、移植均不是患者OS的影响因素(P>0.05)。患者均发生至少1起不良事件,较常报道的≥3级血液学不良事件包括中性粒细胞减少(50.0%)、血小板减少(41.7%)和贫血(25.0%);肝功能损害、肾功能损害发生率较低,分别为16.7%、8.3%;胃肠道不良事件主要是恶心呕吐(83.3%);共有5例患者发生肺炎(41.7%),其中ETP组的1例患者发生≥3级肺炎及≥3级脓毒血症;未报道心血管系统不良事件。结论HDAC抑制剂联合维奈克拉和阿扎胞苷方案对T-ALL患者是一种有效的诱导治疗策略,可实现更高和更深的缓解,且具有良好的安全性和耐受性,为进一步行异基因造血干细胞移植争取最大机会,值得进一步开展大样本研究验证。 展开更多
关键词 白血病 t细胞 组蛋白去乙酰化酶抑制剂 阿扎胞苷 维奈克拉 联合用药 预后
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Improved algorithm of multi-mainlobe interference suppression under uncorrelated and coherent conditions 被引量:1
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作者 CAI Miaohong CHENG Qiang +1 位作者 MENG Jinli ZHAO Dehua 《Journal of Southeast University(English Edition)》 2025年第1期84-90,共7页
A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the s... A new method based on the iterative adaptive algorithm(IAA)and blocking matrix preprocessing(BMP)is proposed to study the suppression of multi-mainlobe interference.The algorithm is applied to precisely estimate the spatial spectrum and the directions of arrival(DOA)of interferences to overcome the drawbacks associated with conventional adaptive beamforming(ABF)methods.The mainlobe interferences are identified by calculating the correlation coefficients between direction steering vectors(SVs)and rejected by the BMP pretreatment.Then,IAA is subsequently employed to reconstruct a sidelobe interference-plus-noise covariance matrix for the preferable ABF and residual interference suppression.Simulation results demonstrate the excellence of the proposed method over normal methods based on BMP and eigen-projection matrix perprocessing(EMP)under both uncorrelated and coherent circumstances. 展开更多
关键词 mainlobe interference suppression adaptive beamforming spatial spectral estimation iterative adaptive algorithm blocking matrix preprocessing
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Intelligent sequential multi-impulse collision avoidance method for non-cooperative spacecraft based on an improved search tree algorithm 被引量:1
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作者 Xuyang CAO Xin NING +4 位作者 Zheng WANG Suyi LIU Fei CHENG Wenlong LI Xiaobin LIAN 《Chinese Journal of Aeronautics》 2025年第4期378-393,共16页
The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making co... The problem of collision avoidance for non-cooperative targets has received significant attention from researchers in recent years.Non-cooperative targets exhibit uncertain states and unpredictable behaviors,making collision avoidance significantly more challenging than that for space debris.Much existing research focuses on the continuous thrust model,whereas the impulsive maneuver model is more appropriate for long-duration and long-distance avoidance missions.Additionally,it is important to minimize the impact on the original mission while avoiding noncooperative targets.On the other hand,the existing avoidance algorithms are computationally complex and time-consuming especially with the limited computing capability of the on-board computer,posing challenges for practical engineering applications.To conquer these difficulties,this paper makes the following key contributions:(A)a turn-based(sequential decision-making)limited-area impulsive collision avoidance model considering the time delay of precision orbit determination is established for the first time;(B)a novel Selection Probability Learning Adaptive Search-depth Search Tree(SPL-ASST)algorithm is proposed for non-cooperative target avoidance,which improves the decision-making efficiency by introducing an adaptive-search-depth mechanism and a neural network into the traditional Monte Carlo Tree Search(MCTS).Numerical simulations confirm the effectiveness and efficiency of the proposed method. 展开更多
关键词 Non-cooperative target Collision avoidance Limited motion area Impulsive maneuver model Search tree algorithm Neural networks
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A Class of Parallel Algorithm for Solving Low-rank Tensor Completion
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作者 LIU Tingyan WEN Ruiping 《应用数学》 北大核心 2025年第4期1134-1144,共11页
In this paper,we established a class of parallel algorithm for solving low-rank tensor completion problem.The main idea is that N singular value decompositions are implemented in N different processors for each slice ... In this paper,we established a class of parallel algorithm for solving low-rank tensor completion problem.The main idea is that N singular value decompositions are implemented in N different processors for each slice matrix under unfold operator,and then the fold operator is used to form the next iteration tensor such that the computing time can be decreased.In theory,we analyze the global convergence of the algorithm.In numerical experiment,the simulation data and real image inpainting are carried out.Experiment results show the parallel algorithm outperform its original algorithm in CPU times under the same precision. 展开更多
关键词 tensor completion Low-rank CONVERGENCE Parallel algorithm
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非小细胞肺癌免疫治疗中的T细胞耗竭——从机制到临床的现状与展望
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作者 白杰 马晓梅 阿木尔札亚 《首都食品与医药》 2026年第1期28-30,共3页
T细胞耗竭是非小细胞肺癌(NSCLC)免疫治疗受限的主要原因,表现为效应功能丧失和抑制性受体高表达。其发生受TOX/TCF-1调控的转录与表观遗传重编程、多重抑制信号、代谢异常及免疫微环境共同影响。耗竭T细胞具有异质性,前体与终末亚群在... T细胞耗竭是非小细胞肺癌(NSCLC)免疫治疗受限的主要原因,表现为效应功能丧失和抑制性受体高表达。其发生受TOX/TCF-1调控的转录与表观遗传重编程、多重抑制信号、代谢异常及免疫微环境共同影响。耗竭T细胞具有异质性,前体与终末亚群在功能和治疗响应中作用不同。联合阻断、代谢和表观遗传干预等策略有望逆转耗竭。 展开更多
关键词 非小细胞肺癌 t细胞耗竭 免疫检查点抑制剂
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An Iterated Greedy Algorithm with Memory and Learning Mechanisms for the Distributed Permutation Flow Shop Scheduling Problem
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作者 Binhui Wang Hongfeng Wang 《Computers, Materials & Continua》 SCIE EI 2025年第1期371-388,共18页
The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because o... The distributed permutation flow shop scheduling problem(DPFSP)has received increasing attention in recent years.The iterated greedy algorithm(IGA)serves as a powerful optimizer for addressing such a problem because of its straightforward,single-solution evolution framework.However,a potential draw-back of IGA is the lack of utilization of historical information,which could lead to an imbalance between exploration and exploitation,especially in large-scale DPFSPs.As a consequence,this paper develops an IGA with memory and learning mechanisms(MLIGA)to efficiently solve the DPFSP targeted at the mini-malmakespan.InMLIGA,we incorporate a memory mechanism to make a more informed selection of the initial solution at each stage of the search,by extending,reconstructing,and reinforcing the information from previous solutions.In addition,we design a twolayer cooperative reinforcement learning approach to intelligently determine the key parameters of IGA and the operations of the memory mechanism.Meanwhile,to ensure that the experience generated by each perturbation operator is fully learned and to reduce the prior parameters of MLIGA,a probability curve-based acceptance criterion is proposed by combining a cube root function with custom rules.At last,a discrete adaptive learning rate is employed to enhance the stability of the memory and learningmechanisms.Complete ablation experiments are utilized to verify the effectiveness of the memory mechanism,and the results show that this mechanism is capable of improving the performance of IGA to a large extent.Furthermore,through comparative experiments involving MLIGA and five state-of-the-art algorithms on 720 benchmarks,we have discovered that MLI-GA demonstrates significant potential for solving large-scale DPFSPs.This indicates that MLIGA is well-suited for real-world distributed flow shop scheduling. 展开更多
关键词 Distributed permutation flow shop scheduling MAKESPAN iterated greedy algorithm memory mechanism cooperative reinforcement learning
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