OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,tradit...OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,traditional Chinese medicine(TCM)herbs exhibit significant bioactivity and therapeutic effect.This study is aimed to evaluate the efficacy of four TCM preparations on 28-day mortality risk of patients and changes of the laboratory indicators.METHODS The retrospective cohort study included patients with COVID-19 who were admitted to the Jiangsu Province Hospital of Chinese Medicine from December 15,2022 to January 15,2023,and those died within 48 hours of admission or cannot be tracked for outcomes were excluded.The primary outcome was survival status in 28 days(death or survival)starting from the day of admission.The second outcomes were laboratory indicators,including absolute lymphocyte count,lactate dehydrogenase,creatinine,and blood urea nitrogen.Binary logistic regressions were used to estimate the effect of TCM preparations on the primary and secondary outcomes in main analysis.Meanwhile,heterogeneity and robustness of results from main analysis were assessed by subgroup analyses and multiple sensitivity analyses.RESULTS 1816 eligible patients were included in analysis dataset,including 573 patients received standard care(control group)and 1243 patients received TCM preparations(hospital preparation group).The 28-day mortality rate of hospital preparation group was lower than that of control group(4.75%vs.14.83%),and the difference was statistically significant(χ^(2)=54.666,P<0.001).The risk of 28-day mortality was 0.535 times lower in the hospital preparation group as compared with the control group(OR=0.46,95%CI:0.305-0.708,P<0.001)showed by multivariable binary logistic regressions.Subgroup analyses showed that taking TCM preparations reduced the 28-day mortality risk.Sensitivity analyses demonstrated that the results of the main analysis for primary outcomes were robust.For secondary outcomes,the risk of abnormal absolute lymphocyte counts at discharge in the hospital preparation group decreased by 0.284 times(OR=0.703,95%CI:0.515-0.961,P=0.027).CONCLUSION Compared with standard of care,taking four hospital preparations including Kanggan Heji,Feining Heji,Qishen Gubiao Keli,and Qianghuo Qushi Qingwen Heji decreased risk of 28-day mortality among hospitalized COVID-19 patients.TCM therapy achieves adequate therapeutic effects in COVID-19.展开更多
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor...BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.展开更多
Heterostructures of organic semi-conductors and transition metal dichalcogenides(TMDs)are viable candidates for superior optoelec-tronic devices.Photoinduced inter-facial charge transfer is crucial for the performance...Heterostructures of organic semi-conductors and transition metal dichalcogenides(TMDs)are viable candidates for superior optoelec-tronic devices.Photoinduced inter-facial charge transfer is crucial for the performance efficiency of such devices,yet the underlying mecha-nism,especially the roles of optical-ly dark triplets and spatially sepa-rated charge transfer states,is poorly understood.In the present work,we obtain the struc-tures of distinct excited states and investigate how they are involved in the charge transfer process at the Pd-octaethylporphyrin(PdOEP)and WS_(2) interface in terms of their energies and couplings.The results show that electron transfer from the triplet PdOEP formed via intersystem crossing prevails over direct electron transfer from the singlet(two orders of magnitude faster).Further analysis reveals that the relatively higher rate of triplet electron transfer compared to singlet electron transfer is mainly attributed to a smaller reorganization energy,which is dominated by the out-of-plane vibrations of the organic component.The work emphasizes the important roles of the optically dark triplets in the electron transfer of the PdOEP@WS_(2) heterostructure,and provides valuable theoretical insights for further improv-ing the optoelectronic performance of TMD-based devices.展开更多
AIM:To establish a risk prediction model for secondary cataract within 2y after pars plana vitrectomy(PPV)in patients with primary rhegmatogenous retinal detachment(RRD).METHODS:Clinical data of patients with primary ...AIM:To establish a risk prediction model for secondary cataract within 2y after pars plana vitrectomy(PPV)in patients with primary rhegmatogenous retinal detachment(RRD).METHODS:Clinical data of patients with primary RRD treated at the Shenzhen Eye Hospital were retrospectively collected.Twenty-four potential influencing factors,including patient characteristics and surgical factors,were selected for analysis.Independent risk factors for secondary cataract were identified through univariate comparisons and multivariate logistic regression analysis.A risk prediction model was constructed and evaluated using receiver operating characteristic(ROC)curves,area under the ROC curve(AUC),calibration plots,and decision curve analysis(DCA)curves.RESULTS:The 386 cases(389 eyes)of patients who underwent PPV and had complete surgical records were ultimately included.Within a 2-year longitudinal observation,41.39%of patients developed cataract secondary to PPV.Logistic regression results identified a history of hypertension[odds ratio(OR)=1.78,95%CI:1.002–3.163,P=0.049],silicone oil tamponade(OR=3.667,95%CI:2.373–5.667,P=0.000),and lens thickness(OR=1.978,95%CI:1.129–3.464,P=0.017)as independent risk factors for cataract secondary to PPV.The constructed nomogram achieved AUC=0.6974.Calibration plots indicated good agreement between predicted and observed outcomes,while DCA curves demonstrated the model’s clinical utility.CONCLUSION:By incorporating a history of hypertension,vitreous substitute type,and lens thickness,this study constructs a prediction model with moderate discriminative ability.This model offers a valuable tool for clinicians to identify high-risk patients early,potentially allowing for more timely interventions and improved patient outcomes.展开更多
Ultrahigh-performance concrete(UHPC)is a groundbreaking kind of concrete that distinguishes itself from conventional concrete through its unique material properties.Understanding and managing the time-dependent charac...Ultrahigh-performance concrete(UHPC)is a groundbreaking kind of concrete that distinguishes itself from conventional concrete through its unique material properties.Understanding and managing the time-dependent characteristics of these materials is essential for their effective use in various construction applications.This study presents an experimental evaluation of the compressive and bending properties of the UHPC incorporating polypropylene,steel,and glass fibers.Based on ACI-211 guidelines,the UHPC mix was designed by using three types of aggregates:limestone,andesite,and quartzite,along with 5%fiber content(at varying percentages of 0,5%,10%,15%,and 20%)relative to the cementitious materials,and three different water-to-cement(w/c)ratios(0.24,0.3,and 0.4)were used.In this research,the compressive and flexural strength tests were conducted.The results show that increasing the values of the fibers significantly enhances the compressive strength of the studied samples.Furthermore,the utilization of fibers markedly improves the bending strength of the samples,demonstrating a strong correlation with the yield resistance of the material.Also,findings show that using steel fibers increases the compressive and bending strength of the tested samples more than polypropylene and glass fibers.For instance,in UHPC samples with 0.4 w/c,the average compressive strength values are 82.2 MPa,70.3 MPa,and 67.1 MPa for steel,polypropylene,and glass fibers,respectively.Also,in the flexural strength test,the modulus of rupture is obtained as an average of 6.24 MPa,5.24 MPa and 4.83 MPa for UHPC samples with steel,polypropylene and glass fibers,respectively.展开更多
BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress an...BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress and anxiety levels,which may further affect their children's educational outcomes.This prospective study examined the relationship between parental anxiety and academic performance of children with ADHD over a 6-year period.AIM To investigate the longitudinal impact of parental anxiety on academic performance in children with ADHD and explore the mediating and moderating factors over a 6-year follow-up period.METHODS A longitudinal cohort study was conducted from 2018 to 2024,enrolling 118 children with ADHD(aged 6-12 years)and their parents from three specialized educational centers.Parental anxiety was assessed using the Parenting Stress Index-4(PSI-4)and Parental Anxiety Scale.Children's academic performance was measured using the Academic Performance Questionnaire and standardized achievement tests.Assessments were conducted at baseline and every 6 months for 3 years.RESULTS Higher parental anxiety scores were significantly associated with poorer academic performance in children with ADHD(β=-0.42,P<0.001).Children of parents with clinically significant anxiety(PSI-4 scores>85th percentile)showed 1.2 standard deviations lower academic achievement than children of parents with normal anxiety levels.The relationship was partially mediated by parent-child interaction quality(indirect effect=-0.18,95%CI:-0.26 to-0.10)and homework supervision practices(indirect effect=-0.15,95%CI:-0.22 to-0.08).CONCLUSION Parental anxiety could significantly affect the academic outcomes of children with ADHD via multiple pathways.Interventions targeting parental mental health may improve the educational outcomes of children with ADHD.展开更多
A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative ...A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.展开更多
The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strateg...The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strategy,the industry predominantly employs a semi-activated control strategy in existing tidal current energy converters.It is essential to identify the differences in predicted energy-harvesting performance between these two controlling strategies through experimental modeling or numerical studies.Furthermore,the suitability of the fully activated control strategy in predicting the energy-harvesting capabilities of oscillating hydrofoils is evaluated.The 2D numerical models of hydrofoil based on fully activated and semi-activated control strategies have been developed and validated.The amplitudes of heaving and pitching movements for the fully activated hydrofoil are determined to match those of the semi-activated hydrofoil.The results show that the main difference between the two control strategies lies in the phase shift occurring between the pitching and heaving motions.This phase shift affects the lift force and its coordination with the heaving velocity,which in turn affects the power output.Notably,the maximum relative efficiency difference obtained between the fully activated and semi-activated control strategies can reach 191%.展开更多
The usage characteristics of the large numerals in child language reflects both linguistic and cognitive development.The present study systematically examined Mandarin children’s naturalistic use of large numerals“...The usage characteristics of the large numerals in child language reflects both linguistic and cognitive development.The present study systematically examined Mandarin children’s naturalistic use of large numerals“bai”,“qian”,and“wan”and compared it with adult usage patterns based on a self-constructed corpus.The results revealed a significant preference for the use of“bai”over both“qian”and“wan”among children and adults alike.This shared pattern suggests that children’s acquisition of large numerals is strongly shaped by adult language input.This study addresses a critical gap in research on the acquisition of large numerals by Mandarin-speaking children,providing valuable insights for the broader theoretical framework of cross-linguistic numerical cognition.展开更多
This paper is committed to an empirical study on the application of common English discourse patterns in the English reading teaching for non-English major students at an average or lower proficiency level.A quantitat...This paper is committed to an empirical study on the application of common English discourse patterns in the English reading teaching for non-English major students at an average or lower proficiency level.A quantitative research method is adopted.The research results show that the application of discourse patterns in teaching in the network environment can help improve students’reading comprehension ability to a certain extent.展开更多
To the editor:The liver’s immune-privileged status allows for a unique microenvironment that supports tumour growth and metastasis.In hepatocellular carcinoma(HCC),the balance between cytotoxic T lymphocytes and regu...To the editor:The liver’s immune-privileged status allows for a unique microenvironment that supports tumour growth and metastasis.In hepatocellular carcinoma(HCC),the balance between cytotoxic T lymphocytes and regulatory T cells plays a crucial role in determining patient outcomes.The expression of programmed cell death ligand 1(PD-1)and other immune checkpoint molecules contributes to a pro-tumourigenic microenvironment and is associated with poor prognosis.Additionally,the heterogeneity of the immune microenvironment adds complexity to disease progression and treatment response.展开更多
With the development of vocational education,cultural study courses play an increasingly important role in cultivating students’overall competence and professional skills.However,many vocational colleges face challen...With the development of vocational education,cultural study courses play an increasingly important role in cultivating students’overall competence and professional skills.However,many vocational colleges face challenges such as outdated teaching content,low student engagement,and insufficient learning outcomes in their cultural study courses.To address these issues,this study introduces the Assurance of Learning(AOL)system,aiming to enhance course quality through a systematic approach.Using Shanghai Zhongqiao University of Technology and Vocational Education as a case study,this research explores the specific pathways for designing and implementing cultural study courses based on the AOL system.During the course design phase,specific and measurable learning objectives are set,and corresponding teaching content and assessment tools are developed to enhance the controllability of the study process.In the implementation phase,various teaching strategies such as project-based learning,case analysis,and field visits are adopted to promote active student participation and effective learning.Additionally,continuous monitoring and feedback mechanisms are employed to continuously adjust and optimize the course content and teaching methods.This study not only provides specific pathways for course improvement in vocational colleges but also verifies the effectiveness of the AOL system in enhancing the quality of cultural study courses.The research findings offer valuable references for other vocational colleges in curriculum reform and quality improvement.展开更多
The Russia-Ukraine conflict remains unresolved,while the armed conflict between Israel and Palestine continues to escalate,causing significant civilian casualties.To better protect the victims of war in armed conflict...The Russia-Ukraine conflict remains unresolved,while the armed conflict between Israel and Palestine continues to escalate,causing significant civilian casualties.To better protect the victims of war in armed conflicts,clarifying the applicability of international human rights law(IHRL)and international humanitarian law(IHL)in such contexts has become an urgent issue.A comparative study on the application of IHRL and IHL needs to address three key questions step by step:First,whether IHRL is applicable during armed conflicts;second,if applicable,how IHRL complements and interacts with IHL;and third,what methods should be adopted to resolve conflicts when IHRL and IHL are applied concurrently.In this context,an analysis of the historical development of IHRL and IHL reveals that the two share a common philosophical foundation,and thus they can be applied concurrently during armed conflicts.From an empirical perspective,IHRL engages with IHL through two approaches:interpreting IHL provisions and directly applying IHRL to armed conflicts,thereby fostering interactive development between the two.In cases where normative conflicts arise between IHRL and IHL,such as in the rules on the use of force and internment procedures,the principles of systemic integration and lex specialis can reconcile these conflicts during the application process.展开更多
This paper focuses on the issue of nurses’job burnout and conducts an in-depth analysis of its contributing factors from multiple dimensions,including organizational management,job characteristics,and individual attr...This paper focuses on the issue of nurses’job burnout and conducts an in-depth analysis of its contributing factors from multiple dimensions,including organizational management,job characteristics,and individual attributes.These factors include shortages in nursing human resources,lack of management support,excessive workload,and differences in coping strategies.Based on this analysis,targeted human resource management strategies are proposed,covering aspects such as optimizing human resource allocation,leadership development and organizational support,humanized management practices,and competency development with supporting systems.The aim is to alleviate nurses’job burnout,improve the quality of nursing work and nurses’professional well-being,and provide theoretical reference and practical guidance for human resource management in the nursing industry.展开更多
As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article ...As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article introduces Professor Fang Gang’s experience in treating obesity-type polycystic ovary syndrome(PCOS)with modified Zhuang Medicine Mao Xia Yin.Professor Fang Gang proposes that the etiology and pathogenesis of obesity-type polycystic ovary syndrome(PCOS)primarily stem from spleen deficiency,which impairs the transport of water and dampness.This dysfunction leads to the accumulation of dampness that transforms into phlegm.Over time,the stagnation of phlegm and dampness generates internal heat,resulting in the formation of“dampness toxin,”“phlegm toxin,”and“heat toxin.”These pathological toxins obstruct the circulation of Qi and blood,causing stasis and the emergence of“stasis toxin.”The buildup of these toxins ultimately blocks the three channels and two pathways,disrupting the harmony among the three Qi of heaven,earth,and man.This disharmony culminates in impaired uterine gland function.Therefore,the treatment mainly focuses on tonifying deficiency,detoxifying,and regulating Qi.展开更多
Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook...Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook integration was analyzed,followed by an explanation of the overall design scheme of textbook integration,and then a series of teaching resources were initially developed and used in teaching practice.Through testing,it was found that the integrative teaching of the two sets of textbooks under the ADDIE model achieved good teaching results,and promoted the three aspects of reading literacy,disciplinary literacy,and value leadership.展开更多
Density(p)and speed of sound(u)findings on the binary liquid mixtures consisting of cyclohexanol(CH—OH),with aniline(A),ortho-chloroaniline(o-CA),and meta-chloroaniline(m-CA)were gathered at the various temperatures ...Density(p)and speed of sound(u)findings on the binary liquid mixtures consisting of cyclohexanol(CH—OH),with aniline(A),ortho-chloroaniline(o-CA),and meta-chloroaniline(m-CA)were gathered at the various temperatures spanning the entire concentration range.303.15,308.15,313.15 and 318.15 K at atmospheric pressure.The information measured there was utilized to compute excess molar volume(V_(m)^(E)),excess isentropic compressibility(K_(S)^(E)),excess of speed of sound(u^(F)),excess intermolecular free length(L_(f)^(F))and excess acoustic impedance(Z^(F)).Further,the partial molar volumes(^(-)V°_(m,1).^(-)V°_(φ,1).^(-)V°_(m,2).^(-)V°_(φ,2)),partial molar compressibilities(K°_(m,1).^(-)K°_(φ,1).^(-)K°_(m,2).^(-)K°_(φ,2))and their excess values(^(-)V^(E)_(m,1).^(-)V^(°E)_(φ,1).^(-)V^(E)_(m,2).^(-)V^(°E)_(φ,2)),(K^(E)_(m,1).^(-)K^(°E)_(φ,1).^(-)K^(E)_(m,2).^(-)K^(°E)_(φ,2))were also computed to perceive more information on molecular interaction and structural effects in these mixtures.Applying the theory of Prigogine-Flory-Patterson(PFP)as a framework,the V_(m)^(E)data of the current liquid mixtures were examined.The analysis of the experimental data took into consideration the interactions that occur between the individual molecules that make up liquid mixtures.By using density functional theory DFT(B3LYP)of 6-31++G(d,P)to analyze the geometries,bond characteristics,interaction energies,and hydrogen bonded complexes in organic solvent phase,quantum chemical calculations were able to further confirm the hydrogen bonding that predominates between cyclohexanol with aniline and chlorosubstituted anilines.展开更多
In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audi...In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audience,imposes distinct requirements on children’s books,compelling translators to approach the text from a child’s perspective.“The Little Prince”has renowned both within and outside of China,and a careful reading of this work can provide us with much inspiration.To this end,the present study adopts the perspective of Gideon Toury’s Descriptive Translation Studies to conduct an in-depth analysis of the different English and Chinese translations in conjunction with the original French novel.This approach aims to better guide literary research and explores translation methods for children’s literature through the analysis of translation norms and rules.展开更多
The exotic Sonneratia apetala in Leizhou Peninsula, has shown outstanding fast-growing ability in restored mangrove forests, at the middle and high tide intertidal zone, with year-round fresh water input from drainage...The exotic Sonneratia apetala in Leizhou Peninsula, has shown outstanding fast-growing ability in restored mangrove forests, at the middle and high tide intertidal zone, with year-round fresh water input from drainage. By setting plot and selecting standard tree, investigation and measurement on height growth, diameter growth, biomass, productivity, and so on, were made in a S. apetala plantation at age of six at Lanbei, Fucheng, Leizhou Peninsula in May 2001. The investigating results showed that the mean annual height growth of plantation was 2.03 m and mean annual growth of diameter at breast height (DBH) was 2.35 cm. There exists a significant correlation between the diameter at ground surface (DGS) and DBH. The average biomass of a single standard tree in dry weight was 95.647 kg/m2. A ratio of above-ground biomass to under-ground biomass was 1.60. The stand biomass of unit area was 22.955 kg/m2, singletree wood volume was 88.23 dm3, and the annual wood volume productivity (PA) of the same year was 0.407. The forest energy accumulation was 424.851 MJ/m2, with annual solar energy fixing rate of 40.68 ×10-7%. It is concluded that S. apetala species had characteristics of outstanding high biomass accumulation and could be used as coastal planting tree species in southern China.展开更多
文摘OBJECTIVE The emergence of evolving variants of Coronavirus disease 2019(COVID-19)has fostered the need for change of newer and adaptive treatments for these infections.During the COVID-19 pandemic and persists,traditional Chinese medicine(TCM)herbs exhibit significant bioactivity and therapeutic effect.This study is aimed to evaluate the efficacy of four TCM preparations on 28-day mortality risk of patients and changes of the laboratory indicators.METHODS The retrospective cohort study included patients with COVID-19 who were admitted to the Jiangsu Province Hospital of Chinese Medicine from December 15,2022 to January 15,2023,and those died within 48 hours of admission or cannot be tracked for outcomes were excluded.The primary outcome was survival status in 28 days(death or survival)starting from the day of admission.The second outcomes were laboratory indicators,including absolute lymphocyte count,lactate dehydrogenase,creatinine,and blood urea nitrogen.Binary logistic regressions were used to estimate the effect of TCM preparations on the primary and secondary outcomes in main analysis.Meanwhile,heterogeneity and robustness of results from main analysis were assessed by subgroup analyses and multiple sensitivity analyses.RESULTS 1816 eligible patients were included in analysis dataset,including 573 patients received standard care(control group)and 1243 patients received TCM preparations(hospital preparation group).The 28-day mortality rate of hospital preparation group was lower than that of control group(4.75%vs.14.83%),and the difference was statistically significant(χ^(2)=54.666,P<0.001).The risk of 28-day mortality was 0.535 times lower in the hospital preparation group as compared with the control group(OR=0.46,95%CI:0.305-0.708,P<0.001)showed by multivariable binary logistic regressions.Subgroup analyses showed that taking TCM preparations reduced the 28-day mortality risk.Sensitivity analyses demonstrated that the results of the main analysis for primary outcomes were robust.For secondary outcomes,the risk of abnormal absolute lymphocyte counts at discharge in the hospital preparation group decreased by 0.284 times(OR=0.703,95%CI:0.515-0.961,P=0.027).CONCLUSION Compared with standard of care,taking four hospital preparations including Kanggan Heji,Feining Heji,Qishen Gubiao Keli,and Qianghuo Qushi Qingwen Heji decreased risk of 28-day mortality among hospitalized COVID-19 patients.TCM therapy achieves adequate therapeutic effects in COVID-19.
基金Supported by National Natural Science Foundation of China,No.82174461Hospital Capability Enhancement Project of Xiyuan Hospital,CACMS,No.XYZX0201-22Technology Innovation Project of China Academy of Chinese Medical Sciences,No.CI2021A01811.
文摘BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.
基金supported by the Fundamental Re-search Funds for the Central Universities(Ganglong Cui)and National Key Research and Development Pro-gram of China(No.2021YFA1500703 to Ganglong Cui)National Natural Science Foundation of China(No.22103067 to Xiao-Ying Xie)and Natural Science Foundation of Shandong Province(No.ZR2021QB105 to Xiao-Ying Xie).
文摘Heterostructures of organic semi-conductors and transition metal dichalcogenides(TMDs)are viable candidates for superior optoelec-tronic devices.Photoinduced inter-facial charge transfer is crucial for the performance efficiency of such devices,yet the underlying mecha-nism,especially the roles of optical-ly dark triplets and spatially sepa-rated charge transfer states,is poorly understood.In the present work,we obtain the struc-tures of distinct excited states and investigate how they are involved in the charge transfer process at the Pd-octaethylporphyrin(PdOEP)and WS_(2) interface in terms of their energies and couplings.The results show that electron transfer from the triplet PdOEP formed via intersystem crossing prevails over direct electron transfer from the singlet(two orders of magnitude faster).Further analysis reveals that the relatively higher rate of triplet electron transfer compared to singlet electron transfer is mainly attributed to a smaller reorganization energy,which is dominated by the out-of-plane vibrations of the organic component.The work emphasizes the important roles of the optically dark triplets in the electron transfer of the PdOEP@WS_(2) heterostructure,and provides valuable theoretical insights for further improv-ing the optoelectronic performance of TMD-based devices.
基金Supported by the Shenzhen Science and Technology Program(No.JCYJ20220818103207015)the SanMing Project of Medicine in Shenzhen(No.SZSM202311012).
文摘AIM:To establish a risk prediction model for secondary cataract within 2y after pars plana vitrectomy(PPV)in patients with primary rhegmatogenous retinal detachment(RRD).METHODS:Clinical data of patients with primary RRD treated at the Shenzhen Eye Hospital were retrospectively collected.Twenty-four potential influencing factors,including patient characteristics and surgical factors,were selected for analysis.Independent risk factors for secondary cataract were identified through univariate comparisons and multivariate logistic regression analysis.A risk prediction model was constructed and evaluated using receiver operating characteristic(ROC)curves,area under the ROC curve(AUC),calibration plots,and decision curve analysis(DCA)curves.RESULTS:The 386 cases(389 eyes)of patients who underwent PPV and had complete surgical records were ultimately included.Within a 2-year longitudinal observation,41.39%of patients developed cataract secondary to PPV.Logistic regression results identified a history of hypertension[odds ratio(OR)=1.78,95%CI:1.002–3.163,P=0.049],silicone oil tamponade(OR=3.667,95%CI:2.373–5.667,P=0.000),and lens thickness(OR=1.978,95%CI:1.129–3.464,P=0.017)as independent risk factors for cataract secondary to PPV.The constructed nomogram achieved AUC=0.6974.Calibration plots indicated good agreement between predicted and observed outcomes,while DCA curves demonstrated the model’s clinical utility.CONCLUSION:By incorporating a history of hypertension,vitreous substitute type,and lens thickness,this study constructs a prediction model with moderate discriminative ability.This model offers a valuable tool for clinicians to identify high-risk patients early,potentially allowing for more timely interventions and improved patient outcomes.
文摘Ultrahigh-performance concrete(UHPC)is a groundbreaking kind of concrete that distinguishes itself from conventional concrete through its unique material properties.Understanding and managing the time-dependent characteristics of these materials is essential for their effective use in various construction applications.This study presents an experimental evaluation of the compressive and bending properties of the UHPC incorporating polypropylene,steel,and glass fibers.Based on ACI-211 guidelines,the UHPC mix was designed by using three types of aggregates:limestone,andesite,and quartzite,along with 5%fiber content(at varying percentages of 0,5%,10%,15%,and 20%)relative to the cementitious materials,and three different water-to-cement(w/c)ratios(0.24,0.3,and 0.4)were used.In this research,the compressive and flexural strength tests were conducted.The results show that increasing the values of the fibers significantly enhances the compressive strength of the studied samples.Furthermore,the utilization of fibers markedly improves the bending strength of the samples,demonstrating a strong correlation with the yield resistance of the material.Also,findings show that using steel fibers increases the compressive and bending strength of the tested samples more than polypropylene and glass fibers.For instance,in UHPC samples with 0.4 w/c,the average compressive strength values are 82.2 MPa,70.3 MPa,and 67.1 MPa for steel,polypropylene,and glass fibers,respectively.Also,in the flexural strength test,the modulus of rupture is obtained as an average of 6.24 MPa,5.24 MPa and 4.83 MPa for UHPC samples with steel,polypropylene and glass fibers,respectively.
文摘BACKGROUND Attention deficit hyperactivity disorder(ADHD)affects approximately 5%of children worldwide and is associated with significant academic impairment.Parents of children with ADHD experience elevated stress and anxiety levels,which may further affect their children's educational outcomes.This prospective study examined the relationship between parental anxiety and academic performance of children with ADHD over a 6-year period.AIM To investigate the longitudinal impact of parental anxiety on academic performance in children with ADHD and explore the mediating and moderating factors over a 6-year follow-up period.METHODS A longitudinal cohort study was conducted from 2018 to 2024,enrolling 118 children with ADHD(aged 6-12 years)and their parents from three specialized educational centers.Parental anxiety was assessed using the Parenting Stress Index-4(PSI-4)and Parental Anxiety Scale.Children's academic performance was measured using the Academic Performance Questionnaire and standardized achievement tests.Assessments were conducted at baseline and every 6 months for 3 years.RESULTS Higher parental anxiety scores were significantly associated with poorer academic performance in children with ADHD(β=-0.42,P<0.001).Children of parents with clinically significant anxiety(PSI-4 scores>85th percentile)showed 1.2 standard deviations lower academic achievement than children of parents with normal anxiety levels.The relationship was partially mediated by parent-child interaction quality(indirect effect=-0.18,95%CI:-0.26 to-0.10)and homework supervision practices(indirect effect=-0.15,95%CI:-0.22 to-0.08).CONCLUSION Parental anxiety could significantly affect the academic outcomes of children with ADHD via multiple pathways.Interventions targeting parental mental health may improve the educational outcomes of children with ADHD.
基金Sponsored by Vocational Education Teaching Reform Research Project of Shandong Province“Research on Digital New-Form Curriculum Development Based on AI Knowledge Maps in the Context of Industry-Education Integration”(2023352)Vocational Education Teaching Reform Research Project of Shandong Province“Innovation and Practice in the Development Model of Vocational College Master Craftsman Studios under the Perspective of Industry-Education Integration”(2024375).
文摘A“smart course”denotes a learner-centered curriculum model that deeply integrates advanced technologies,including generative artificial intelligence(AI)and big data analytics,with ongoing optimization and iterative refinement.This paper examines the pathways of smart course development in higher vocational education by using the Study Tour Course Design course as a practical case study.The analysis is conducted from four perspectives:innovation in educational concepts,innovation in teaching models,transformation in learning paradigms,and enhancement in evaluation systems.By developing a threedimensional framework encompassing“knowledge,skills,and problems”,the focus of education shifts from“knowledge imparting”to“competency development”.This approach fosters a transformation in teaching interactions,moving beyond the traditional“teacher and student interaction”to a more integrated trinity collaboration of“teachers,students,and machines”,and promotes the transformation of students’learning from“passive receptive learning”to“autonomous inquiry-based learning”.Simultaneously,it facilitates the transition of evaluation methods from“outcome-based evaluation”to“multi-dimensional evaluation”.
基金supported by the Shandong Natural Science Foundation Youth Project(No.ZR2023QE075)the Open Project Program of Shandong Marine Aerospace Equipment Technological Innovation Center(No.MAETIC202210)the Shandong Natural Science Foundation Project(No.ZR2022ME145)。
文摘The oscillating hydrofoil represents a promising technology for harvesting energy from tidal currents.While previous research has primarily focused on oscillating hydrofoils utilizing a fully activated control strategy,the industry predominantly employs a semi-activated control strategy in existing tidal current energy converters.It is essential to identify the differences in predicted energy-harvesting performance between these two controlling strategies through experimental modeling or numerical studies.Furthermore,the suitability of the fully activated control strategy in predicting the energy-harvesting capabilities of oscillating hydrofoils is evaluated.The 2D numerical models of hydrofoil based on fully activated and semi-activated control strategies have been developed and validated.The amplitudes of heaving and pitching movements for the fully activated hydrofoil are determined to match those of the semi-activated hydrofoil.The results show that the main difference between the two control strategies lies in the phase shift occurring between the pitching and heaving motions.This phase shift affects the lift force and its coordination with the heaving velocity,which in turn affects the power output.Notably,the maximum relative efficiency difference obtained between the fully activated and semi-activated control strategies can reach 191%.
文摘The usage characteristics of the large numerals in child language reflects both linguistic and cognitive development.The present study systematically examined Mandarin children’s naturalistic use of large numerals“bai”,“qian”,and“wan”and compared it with adult usage patterns based on a self-constructed corpus.The results revealed a significant preference for the use of“bai”over both“qian”and“wan”among children and adults alike.This shared pattern suggests that children’s acquisition of large numerals is strongly shaped by adult language input.This study addresses a critical gap in research on the acquisition of large numerals by Mandarin-speaking children,providing valuable insights for the broader theoretical framework of cross-linguistic numerical cognition.
基金General Project for Educational and Teaching Reform of Xinjiang Yili Normal University,2022:Empirical Study on the Reform of College English Reading Teaching Based on Discourse Patterns in Network Environment.Funding amount:CNY 10,000.Duration:April 2022-April 2025(Project No.:YSYB202268).
文摘This paper is committed to an empirical study on the application of common English discourse patterns in the English reading teaching for non-English major students at an average or lower proficiency level.A quantitative research method is adopted.The research results show that the application of discourse patterns in teaching in the network environment can help improve students’reading comprehension ability to a certain extent.
基金supported by Jiangsu Commission of Health(No.x202308)The Suzhou Gusu Health Talents Scientific Research Project(No.GSWS2021052).
文摘To the editor:The liver’s immune-privileged status allows for a unique microenvironment that supports tumour growth and metastasis.In hepatocellular carcinoma(HCC),the balance between cytotoxic T lymphocytes and regulatory T cells plays a crucial role in determining patient outcomes.The expression of programmed cell death ligand 1(PD-1)and other immune checkpoint molecules contributes to a pro-tumourigenic microenvironment and is associated with poor prognosis.Additionally,the heterogeneity of the immune microenvironment adds complexity to disease progression and treatment response.
基金Phase achievements of the“Civilian Teacher Plan”project for Shanghai’s private universities in 2023Establishing the“Three Hundred Miles”Research and Learning Base to Promote Innovation in the“Great Ideological and Political Course”(2025 Private 06-01-15)。
文摘With the development of vocational education,cultural study courses play an increasingly important role in cultivating students’overall competence and professional skills.However,many vocational colleges face challenges such as outdated teaching content,low student engagement,and insufficient learning outcomes in their cultural study courses.To address these issues,this study introduces the Assurance of Learning(AOL)system,aiming to enhance course quality through a systematic approach.Using Shanghai Zhongqiao University of Technology and Vocational Education as a case study,this research explores the specific pathways for designing and implementing cultural study courses based on the AOL system.During the course design phase,specific and measurable learning objectives are set,and corresponding teaching content and assessment tools are developed to enhance the controllability of the study process.In the implementation phase,various teaching strategies such as project-based learning,case analysis,and field visits are adopted to promote active student participation and effective learning.Additionally,continuous monitoring and feedback mechanisms are employed to continuously adjust and optimize the course content and teaching methods.This study not only provides specific pathways for course improvement in vocational colleges but also verifies the effectiveness of the AOL system in enhancing the quality of cultural study courses.The research findings offer valuable references for other vocational colleges in curriculum reform and quality improvement.
文摘The Russia-Ukraine conflict remains unresolved,while the armed conflict between Israel and Palestine continues to escalate,causing significant civilian casualties.To better protect the victims of war in armed conflicts,clarifying the applicability of international human rights law(IHRL)and international humanitarian law(IHL)in such contexts has become an urgent issue.A comparative study on the application of IHRL and IHL needs to address three key questions step by step:First,whether IHRL is applicable during armed conflicts;second,if applicable,how IHRL complements and interacts with IHL;and third,what methods should be adopted to resolve conflicts when IHRL and IHL are applied concurrently.In this context,an analysis of the historical development of IHRL and IHL reveals that the two share a common philosophical foundation,and thus they can be applied concurrently during armed conflicts.From an empirical perspective,IHRL engages with IHL through two approaches:interpreting IHL provisions and directly applying IHRL to armed conflicts,thereby fostering interactive development between the two.In cases where normative conflicts arise between IHRL and IHL,such as in the rules on the use of force and internment procedures,the principles of systemic integration and lex specialis can reconcile these conflicts during the application process.
基金Zhejiang Provincial Medical and Health Science and Technology Projects(Project No:2024KY1339)。
文摘This paper focuses on the issue of nurses’job burnout and conducts an in-depth analysis of its contributing factors from multiple dimensions,including organizational management,job characteristics,and individual attributes.These factors include shortages in nursing human resources,lack of management support,excessive workload,and differences in coping strategies.Based on this analysis,targeted human resource management strategies are proposed,covering aspects such as optimizing human resource allocation,leadership development and organizational support,humanized management practices,and competency development with supporting systems.The aim is to alleviate nurses’job burnout,improve the quality of nursing work and nurses’professional well-being,and provide theoretical reference and practical guidance for human resource management in the nursing industry.
基金National Administration of Traditional Chinese Medicine high-level key discipline construction project on Ethnic Minority Medicine(Zhuang Medicine)(Project No.:zyyzdxk-2023164)Guangxi Higher Education Key Laboratory for Research on Toxin-related Diseases in Zhuang Medicine(Guijiao Keyan[2022]No.10).
文摘As an important branch of traditional medicine,Zhuang Medicine is renowned for its unique prescriptions and techniques in clinical treatment,with significant therapeutic effects and widespread popularity.This article introduces Professor Fang Gang’s experience in treating obesity-type polycystic ovary syndrome(PCOS)with modified Zhuang Medicine Mao Xia Yin.Professor Fang Gang proposes that the etiology and pathogenesis of obesity-type polycystic ovary syndrome(PCOS)primarily stem from spleen deficiency,which impairs the transport of water and dampness.This dysfunction leads to the accumulation of dampness that transforms into phlegm.Over time,the stagnation of phlegm and dampness generates internal heat,resulting in the formation of“dampness toxin,”“phlegm toxin,”and“heat toxin.”These pathological toxins obstruct the circulation of Qi and blood,causing stasis and the emergence of“stasis toxin.”The buildup of these toxins ultimately blocks the three channels and two pathways,disrupting the harmony among the three Qi of heaven,earth,and man.This disharmony culminates in impaired uterine gland function.Therefore,the treatment mainly focuses on tonifying deficiency,detoxifying,and regulating Qi.
基金funded by Project Information:2022 Guangzhou Municipal Higher Education Teaching Research and Reform Key Research Project:“Innovation and Practice of English Reading Curriculum Ideological and Political in Colleges and Universities:A Study on the Integration of Understanding Contemporary China:An English Reading and Writing Textbook and English Reading Teaching”(2023JGZDXM001).
文摘Based on the ADDIE model,we explored the integration path between Understanding Contemporary China:An English Reading and Writing Textbook and the main textbook of college English reading.Firstly,the basis of textbook integration was analyzed,followed by an explanation of the overall design scheme of textbook integration,and then a series of teaching resources were initially developed and used in teaching practice.Through testing,it was found that the integrative teaching of the two sets of textbooks under the ADDIE model achieved good teaching results,and promoted the three aspects of reading literacy,disciplinary literacy,and value leadership.
文摘Density(p)and speed of sound(u)findings on the binary liquid mixtures consisting of cyclohexanol(CH—OH),with aniline(A),ortho-chloroaniline(o-CA),and meta-chloroaniline(m-CA)were gathered at the various temperatures spanning the entire concentration range.303.15,308.15,313.15 and 318.15 K at atmospheric pressure.The information measured there was utilized to compute excess molar volume(V_(m)^(E)),excess isentropic compressibility(K_(S)^(E)),excess of speed of sound(u^(F)),excess intermolecular free length(L_(f)^(F))and excess acoustic impedance(Z^(F)).Further,the partial molar volumes(^(-)V°_(m,1).^(-)V°_(φ,1).^(-)V°_(m,2).^(-)V°_(φ,2)),partial molar compressibilities(K°_(m,1).^(-)K°_(φ,1).^(-)K°_(m,2).^(-)K°_(φ,2))and their excess values(^(-)V^(E)_(m,1).^(-)V^(°E)_(φ,1).^(-)V^(E)_(m,2).^(-)V^(°E)_(φ,2)),(K^(E)_(m,1).^(-)K^(°E)_(φ,1).^(-)K^(E)_(m,2).^(-)K^(°E)_(φ,2))were also computed to perceive more information on molecular interaction and structural effects in these mixtures.Applying the theory of Prigogine-Flory-Patterson(PFP)as a framework,the V_(m)^(E)data of the current liquid mixtures were examined.The analysis of the experimental data took into consideration the interactions that occur between the individual molecules that make up liquid mixtures.By using density functional theory DFT(B3LYP)of 6-31++G(d,P)to analyze the geometries,bond characteristics,interaction energies,and hydrogen bonded complexes in organic solvent phase,quantum chemical calculations were able to further confirm the hydrogen bonding that predominates between cyclohexanol with aniline and chlorosubstituted anilines.
文摘In modern society,the globalization of literary works is evident,with exceptional literary pieces from various countries spreading worldwide.Among these,children’s literature,due to the specificity of its target audience,imposes distinct requirements on children’s books,compelling translators to approach the text from a child’s perspective.“The Little Prince”has renowned both within and outside of China,and a careful reading of this work can provide us with much inspiration.To this end,the present study adopts the perspective of Gideon Toury’s Descriptive Translation Studies to conduct an in-depth analysis of the different English and Chinese translations in conjunction with the original French novel.This approach aims to better guide literary research and explores translation methods for children’s literature through the analysis of translation norms and rules.
基金The paper was supported by the project of integrated mangrove management and coastal protection(IMMCP) in Leizhou Peninsula Guangdong Province.
文摘The exotic Sonneratia apetala in Leizhou Peninsula, has shown outstanding fast-growing ability in restored mangrove forests, at the middle and high tide intertidal zone, with year-round fresh water input from drainage. By setting plot and selecting standard tree, investigation and measurement on height growth, diameter growth, biomass, productivity, and so on, were made in a S. apetala plantation at age of six at Lanbei, Fucheng, Leizhou Peninsula in May 2001. The investigating results showed that the mean annual height growth of plantation was 2.03 m and mean annual growth of diameter at breast height (DBH) was 2.35 cm. There exists a significant correlation between the diameter at ground surface (DGS) and DBH. The average biomass of a single standard tree in dry weight was 95.647 kg/m2. A ratio of above-ground biomass to under-ground biomass was 1.60. The stand biomass of unit area was 22.955 kg/m2, singletree wood volume was 88.23 dm3, and the annual wood volume productivity (PA) of the same year was 0.407. The forest energy accumulation was 424.851 MJ/m2, with annual solar energy fixing rate of 40.68 ×10-7%. It is concluded that S. apetala species had characteristics of outstanding high biomass accumulation and could be used as coastal planting tree species in southern China.
