OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with de...OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with deficiency-inducing factors,including irregular feeding and tail clamping.Mice were administered Fuling(Poria) and its extracts(raw/cooked powder,aqueous/alcohol extract) by gavage once a day for 21 d.The body weight,rectal temperature,and spleen and thymus organ coefficients were calculated.The levels of motilin(MTL),gastrin(GAS),aquaporin 2(AQP2),interleukin 2(IL-2),IL-4,and 5-hydroxytryptamine(5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.RESULTS:Fuling(Poria) and its extracts did not change the body weight,rectal temperature,and organ coefficients of the spleen and thymus.However,it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2.In addition,the levels of IL-4 and 5-HT showed no significant alteration.CONCLUSIONS:These results suggested the crucial function of Fuling(Poria) in SDSP,especially promoting digestive function and water metabolism.展开更多
Objective:To observe the effects of point application combined with abdominal Tuina(Chinese therapeutic massage)on epigastric pain due to deficient cold of spleen and stomach.Methods:A total of 182 patients with epiga...Objective:To observe the effects of point application combined with abdominal Tuina(Chinese therapeutic massage)on epigastric pain due to deficient cold of spleen and stomach.Methods:A total of 182 patients with epigastric pain due to deficient cold of spleen and stomach were randomly divided into a control group and a combined group using the random number table method,with 91 cases in each group.Both groups received identical standard interventions.Patients in the control group were treated with abdominal Tuina therapy,while patients in the combined group were treated with point application therapy in addition to the intervention in the control group.The clinical efficacy was compared,and changes in the visual analog scale(VAS),quality of life(QOL),traditional Chinese medicine(TCM)symptom score,serum motilin(MTL),gastrin(GAS),and epidermal growth factor(EGF),and serum inflammatory factors[interleukin(IL)-4 and IL-6]were observed after 4 weeks of treatment.Results:After 4 weeks of treatment,the total effective rate of the combined group was higher than that of the control group(P<0.05).The VAS score,serum IL-4 and IL-6 levels,and TCM symptom score decreased in both groups(P<0.05)and were lower in the combined group than in the control group(P<0.05).The levels of MTL,GAS,and EGF,and QOL score increased in both groups(P<0.05)and were higher in the combined group than in the control group(P<0.05).Conclusion:In addition to standard interventions,the efficacy of abdominal Tuina combined with point application in the treatment of epigastric pain due to deficient cold of spleen and stomach is better than that of abdominal Tuina alone;this combined method is more effective in alleviating pain and clinical symptoms,reducing serum inflammatory factor levels,and regulating gastrointestinal hormones.展开更多
Objective:To evaluate the clinical efficacy of umbilical herbal application combined with pestle needle therapy in the treatment of functional diarrhea(FD)due to deficient cold of the spleen and stomach.Methods:A tota...Objective:To evaluate the clinical efficacy of umbilical herbal application combined with pestle needle therapy in the treatment of functional diarrhea(FD)due to deficient cold of the spleen and stomach.Methods:A total of 72 patients with FD were enrolled and randomly assigned to two groups using the random number table method,with 36 patients in each group.Both groups received conventional Western medication treatment.The observation group additionally received umbilical application of Wen Yang Bu Pi Gao(Yang-warming and spleenstrengthening herbal paste)combined with pestle needle therapy.After 7 d of treatment,the clinical efficacy was assessed.Traditional Chinese medicine(TCM)symptom scores,irritable bowel syndrome-quality of life(IBS-QOL)score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 91.7%,which was significantly higher than 69.4%in the control group(P<0.05).After treatment,TCM symptom and IBS-QOL scores in both groups were significantly reduced compared to those before treatment(P<0.05),and the scores in the observation group were significantly lower than those in the control group(P<0.05).No adverse reactions occurred in either group during the treatment period.Conclusion:Compared to conventional Western medication treatment alone,the addition of umbilical application of Wen Yang Bu Pi Gao combined with pestle needle therapy can more effectively alleviate clinical symptoms and improve the quality of life in patients with FD due to deficient cold of the spleen and stomach.展开更多
Objective To observe the clinical efficacy of acupuncture and moxibustion for functional dyspepsia(FD)due to Yang deficiency of the spleen and stomach.Methods A total of 90 patients meeting the inclusion criteria of F...Objective To observe the clinical efficacy of acupuncture and moxibustion for functional dyspepsia(FD)due to Yang deficiency of the spleen and stomach.Methods A total of 90 patients meeting the inclusion criteria of FD due to Yang deficiency of the spleen and stomach were randomized into an acupuncture-moxibustion group,an electroacupuncture(EA)group,and a mosapride group by the random number table method,with 30 cases in each group.The mosapride group was treated with mosapride citrate dispersible tablets.The EA group was treated with EA treatment.The acupuncture-moxibustion group was treated with additional moxibustion therapy based on the treatment in the EA group.All three groups took 10 d as one treatment course and 2 courses in total,with a 2-day interval between two courses.The traditional Chinese medicine(TCM)symptoms score,functional digestive disorder quality of life questionnaire(FDDQL)score,oral-colon transit time(OCTT),and serum glucagon-like peptide-1(GLP-1)level was compared before and after treatment among the three groups.And the clinical efficacy was evaluated.Results The total effective rate in the acupuncture-moxibustion group was 96.7%,which was higher than 86.7%in the EA group and 73.3%in the mosapride group,and the total effective rate in the EA group was higher than that in the mosapride group;the inter-group differences were all statistically significant(P<0.05).After treatment,the TCM symptom score in the three groups was lower than that before treatment(P<0.05),and the FDDQL score was higher than that before treatment(P<0.05).The change after treatment in the TCM symptom score in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group,and the change in the acupuncture-moxibustion group was more significant than that in the EA group;the inter-group differences were statistically significant(P<0.05).The change after treatment in the FDDQL score in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group,and the change in the acupuncture-moxibustion group was larger than that in the EA group;the inter-group differences were all statistically significant(P<0.05).After treatment,the OCTT in all three groups was lower than that before treatment(P<0.05),and the serum GLP-1 level was higher than that before treatment(P<0.05);the change after treatment in the OCTT in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group,and the change in the acupuncture-moxibustion group was more significant than that in the EA group;the inter-group differences were statistically significant(P<0.05).The change after treatment in the serum GLP-1 level in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group,and the change in the acupuncture-moxibustion group was larger than that in the EA group;the inter-group differences were statistically significant(P<0.05).Conclusion Acupuncture and moxibustion can improve the clinical symptoms in patients with FD and enhance their quality of life,producing better effects than EA or mosapride alone.Shortening gastrointestinal movement time and increasing gastrointestinal hormone levels may be its mechanism.展开更多
基金Supported by National Key Research and Development Program of China:Study on the Core Efficacy Evaluation of Fuling(Poria)(No.2017YFC1703005)。
文摘OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with deficiency-inducing factors,including irregular feeding and tail clamping.Mice were administered Fuling(Poria) and its extracts(raw/cooked powder,aqueous/alcohol extract) by gavage once a day for 21 d.The body weight,rectal temperature,and spleen and thymus organ coefficients were calculated.The levels of motilin(MTL),gastrin(GAS),aquaporin 2(AQP2),interleukin 2(IL-2),IL-4,and 5-hydroxytryptamine(5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.RESULTS:Fuling(Poria) and its extracts did not change the body weight,rectal temperature,and organ coefficients of the spleen and thymus.However,it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2.In addition,the levels of IL-4 and 5-HT showed no significant alteration.CONCLUSIONS:These results suggested the crucial function of Fuling(Poria) in SDSP,especially promoting digestive function and water metabolism.
文摘Objective:To observe the effects of point application combined with abdominal Tuina(Chinese therapeutic massage)on epigastric pain due to deficient cold of spleen and stomach.Methods:A total of 182 patients with epigastric pain due to deficient cold of spleen and stomach were randomly divided into a control group and a combined group using the random number table method,with 91 cases in each group.Both groups received identical standard interventions.Patients in the control group were treated with abdominal Tuina therapy,while patients in the combined group were treated with point application therapy in addition to the intervention in the control group.The clinical efficacy was compared,and changes in the visual analog scale(VAS),quality of life(QOL),traditional Chinese medicine(TCM)symptom score,serum motilin(MTL),gastrin(GAS),and epidermal growth factor(EGF),and serum inflammatory factors[interleukin(IL)-4 and IL-6]were observed after 4 weeks of treatment.Results:After 4 weeks of treatment,the total effective rate of the combined group was higher than that of the control group(P<0.05).The VAS score,serum IL-4 and IL-6 levels,and TCM symptom score decreased in both groups(P<0.05)and were lower in the combined group than in the control group(P<0.05).The levels of MTL,GAS,and EGF,and QOL score increased in both groups(P<0.05)and were higher in the combined group than in the control group(P<0.05).Conclusion:In addition to standard interventions,the efficacy of abdominal Tuina combined with point application in the treatment of epigastric pain due to deficient cold of spleen and stomach is better than that of abdominal Tuina alone;this combined method is more effective in alleviating pain and clinical symptoms,reducing serum inflammatory factor levels,and regulating gastrointestinal hormones.
基金supported by 2023 Annual Public Welfare Technological Application Research Project of Jinhua City(2023年度金华市公益性技术应用研究项目,No.2023-4-256).
文摘Objective:To evaluate the clinical efficacy of umbilical herbal application combined with pestle needle therapy in the treatment of functional diarrhea(FD)due to deficient cold of the spleen and stomach.Methods:A total of 72 patients with FD were enrolled and randomly assigned to two groups using the random number table method,with 36 patients in each group.Both groups received conventional Western medication treatment.The observation group additionally received umbilical application of Wen Yang Bu Pi Gao(Yang-warming and spleenstrengthening herbal paste)combined with pestle needle therapy.After 7 d of treatment,the clinical efficacy was assessed.Traditional Chinese medicine(TCM)symptom scores,irritable bowel syndrome-quality of life(IBS-QOL)score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was 91.7%,which was significantly higher than 69.4%in the control group(P<0.05).After treatment,TCM symptom and IBS-QOL scores in both groups were significantly reduced compared to those before treatment(P<0.05),and the scores in the observation group were significantly lower than those in the control group(P<0.05).No adverse reactions occurred in either group during the treatment period.Conclusion:Compared to conventional Western medication treatment alone,the addition of umbilical application of Wen Yang Bu Pi Gao combined with pestle needle therapy can more effectively alleviate clinical symptoms and improve the quality of life in patients with FD due to deficient cold of the spleen and stomach.
基金This work was supported by the Project of Hunan Provincial Natural Science Foundation of China(湖南省自然科学基金项目,No.2022JJ40301)Fund Project of Hunan Province Education Office(湖南省教育厅科学研究项目,No.21B0369)Scientific Fund Project of Hunan University of Chinese Medicine(湖南中医药大学科研基金项目,No.2021XJJJ013).
文摘Objective To observe the clinical efficacy of acupuncture and moxibustion for functional dyspepsia(FD)due to Yang deficiency of the spleen and stomach.Methods A total of 90 patients meeting the inclusion criteria of FD due to Yang deficiency of the spleen and stomach were randomized into an acupuncture-moxibustion group,an electroacupuncture(EA)group,and a mosapride group by the random number table method,with 30 cases in each group.The mosapride group was treated with mosapride citrate dispersible tablets.The EA group was treated with EA treatment.The acupuncture-moxibustion group was treated with additional moxibustion therapy based on the treatment in the EA group.All three groups took 10 d as one treatment course and 2 courses in total,with a 2-day interval between two courses.The traditional Chinese medicine(TCM)symptoms score,functional digestive disorder quality of life questionnaire(FDDQL)score,oral-colon transit time(OCTT),and serum glucagon-like peptide-1(GLP-1)level was compared before and after treatment among the three groups.And the clinical efficacy was evaluated.Results The total effective rate in the acupuncture-moxibustion group was 96.7%,which was higher than 86.7%in the EA group and 73.3%in the mosapride group,and the total effective rate in the EA group was higher than that in the mosapride group;the inter-group differences were all statistically significant(P<0.05).After treatment,the TCM symptom score in the three groups was lower than that before treatment(P<0.05),and the FDDQL score was higher than that before treatment(P<0.05).The change after treatment in the TCM symptom score in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group,and the change in the acupuncture-moxibustion group was more significant than that in the EA group;the inter-group differences were statistically significant(P<0.05).The change after treatment in the FDDQL score in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group,and the change in the acupuncture-moxibustion group was larger than that in the EA group;the inter-group differences were all statistically significant(P<0.05).After treatment,the OCTT in all three groups was lower than that before treatment(P<0.05),and the serum GLP-1 level was higher than that before treatment(P<0.05);the change after treatment in the OCTT in the acupuncture-moxibustion group and the EA group was more significant than that in the mosapride group,and the change in the acupuncture-moxibustion group was more significant than that in the EA group;the inter-group differences were statistically significant(P<0.05).The change after treatment in the serum GLP-1 level in the acupuncture-moxibustion group and the EA group was greater than that in the mosapride group,and the change in the acupuncture-moxibustion group was larger than that in the EA group;the inter-group differences were statistically significant(P<0.05).Conclusion Acupuncture and moxibustion can improve the clinical symptoms in patients with FD and enhance their quality of life,producing better effects than EA or mosapride alone.Shortening gastrointestinal movement time and increasing gastrointestinal hormone levels may be its mechanism.
