Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limite...Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limited,and understanding of the variable“TikTok brain”is still in its infancy.Therefore,based on the Stimulus-Organism-Behavior-Consequence(SOBC)framework,we proposed six research hypotheses and constructed a model to explore the relationships between short video usage intensity,TikTok brain,short video addiction,and decreased attention control.Methods:Given that students are considered a high-risk group for excessive short video use,we collected 1086 valid participants from Chinese student users,including 609 males(56.1%)and 477 females(43.9%),with an average participant age of 19.84 years,to test the hypotheses.Results:(1)Short video usage intensity was positively related to short video addiction,TikTok brain,and decreased attention control;(2)TikTok brain was positively related to short video addiction and decreased attention control;and(3)Short video addiction was positively related to decreased attention control.Conclusions:These findings suggest that although excessive use of short video applications brings negative consequences,users still spend significant amounts of time on these platforms,indicating a need for strict self-regulation of usage time.展开更多
BACKGROUND Total hip arthroplasty(THA)has increased along with an increasing demand for improved quality of life.Combined with prolonged life expectancy,the number of revision surgeries is expected to increase.Stress ...BACKGROUND Total hip arthroplasty(THA)has increased along with an increasing demand for improved quality of life.Combined with prolonged life expectancy,the number of revision surgeries is expected to increase.Stress shielding is a significant issue with traditional femoral stems used in THA,making revision surgeries particularly challenging in younger patients.This has sparked renewed interest in studying safety and functional outcomes of short metaphyseal femoral stems,which have the potential to alleviate these challenges and simplify revision surgeries.AIM To evaluate the long-term outcomes of short-stem THA.METHODS A total of 124 hips that underwent THA using the short femoral stem(TRILOCK®Depuy)between May 2006 and November 2008 were included in this study.Patients were followed for a period of 15 years.Outcomes were assessed in terms of pain relief,hip joint range of motion,improvement in mobility,and functional outcomes using the modified Harris Hip Score,Oxford hip score,and Western Ontario and McMaster Universities Osteoarthritis index score.RESULTS A total of 124 hips in 98 patients were evaluated.Significant improvements in functional outcomes were observed over the 15-year follow-up period,with no cases of subsidence,implant loosening,or complications necessitating revision surgery.The only complication reported was heterotopic ossification in 1 patient.CONCLUSION Short metaphyseal stems provide better functional outcomes with early mobilization,and its long-term follow-up without subsidence,implant loosening,or proximal femoral bone loss simplifies revision surgery in younger patients.展开更多
Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’...Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.展开更多
Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This r...Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.展开更多
Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression...Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression in rice remains unclear.Here,we construct a map of 137,629 polymorphic STRs in the rice(Oryza sativa L.)genome using a population-scale resequencing dataset.A genome-wide survey encompassing 4726 accessions shows that the occurrence frequency,mutational patterns,chromosomal distribution,and functional properties of STRs are correlated with the sequences and lengths of repeat motifs.Leveraging a transcriptome dataset from 127 rice accessions,we identify 44,672 expression STRs(eSTRs)by modeling gene expression in response to the length variation of STRs.These eSTRs are notably enriched in the regulatory regions of genes with active transcriptional signatures.Population analysis identifies numerous STRs that have undergone genetic divergence among different rice groups and 1726 tagged STRs that may be associated with agronomic traits.By editing the(ACT)_(7) STR in OsFD1 promoter,we further experimentally validate its role in regulating gene expression and phenotype.Our study highlights the contribution of STRs to transcriptional regulation in plants and establishes the foundation for their potential use as alternative targets for genetic improvement.展开更多
In the wave of internet culture,short videos have become an indispensable medium for social communication.The metaphorical hot words contained within them serve as a unique linguistic phenomenon that leads topics and ...In the wave of internet culture,short videos have become an indispensable medium for social communication.The metaphorical hot words contained within them serve as a unique linguistic phenomenon that leads topics and focuses attention,greatly enriching the expressive layers and rhetorical charm of short videos,and significantly enhancing the video’s theme orientation and emotional identification.This research aims to explore the relationship between the use of metaphorical Internet buzzwords in short videos and the thematic and emotional orientation.The study adopts a combination of qualitative and quantitative methods,taking 10 videos with over 10,000 likes posted by a well-known blogger on Xiaohongshu in 2024 as the research object,transcribing the text,forming research corpora,and conducting multi-dimensional cognitive analysis on them.The study shows that about half of short videos contain metaphorical hot words.Different types of metaphorical hot words can trigger different emotional reactions from fans,especially humorous metaphorical hot words that can stimulate fans’emotional identification and resonance.In addition,in terms of fan participation,videos using metaphorical hot words tend to attract more fan attention than those that do not:these videos not only attract more fans to watch and like,but also trigger more comments and sharing behaviors.In summary,short videos cleverly use metaphors to create internet hot words,significantly enhancing the video’s thematic guidance and emotional resonance,manifested in creating popular topics,clarifying guiding themes,enhancing content attractiveness,and stimulating strong emotional identification,thereby promoting interactive behaviors such as likes and shares.These findings provide a reference for research in related fields such as metaphor,communication studies,and sociology.展开更多
Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance predicti...Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance prediction may be resolved by machine learning using weather datasets.This study emphasises the daily and monthly global solar radiation data predictions of three locations,Pretoria,Bloemfontein,and Vuwani,at different provinces in South Africa with various solar radiation distributions.The study evaluated five different machine learning models.Forecasting models were established to evaluate global solar radiation,focusing on input data.The selected forecast models are centered on their ability to perform with time series data.These models use five years of data from meteorological parameters,such as global horizontal irradiance(GHI),relative humidity,wind speed and ambient temperature between 1 January 2018 and 31 December 2022.The datasets from these meteorological parameters are utilised for training and testing the employed algorithms,which are examined using five statistical metrics.Moreover,the inconsistency of the solar irradiance time series was equally assessed using the clearness index.The results from this study demonstrate that the R2 value recording 0.866 datasets in Bloemfontein of random forest algorithm presents the highest performance during the training processes for all models studied,while the random tree in Vuwani showed the lowest performance of R2 of 0.210 with other algorithms in testing processes.Additionally,the maximum solar radiation was found in December for both Pretoria and Bloemfontein,recorded as 5.347 and 5.844 kWh/m2/day,respectively,while it was 4.692 kWh/m2/day at Vuwani in January.Similarly,the average clearness index of 0.605,0.657 and 0.533 are obtained at Pretoria,Bloemfontein,and Vuwani,respectively.Among the three sites under study,the solar radiation and clearness index are higher in Bloemfontein.Therefore,the proposed algorithms could be used conveniently for short-and long-term solar power plants in South Africa.展开更多
BACKGROUND Kidney transplantation is increasingly more common due to the ongoing shortage of deceased donors.However,anatomical challenges,such as a short renal artery,can complicate surgical procedures and increase c...BACKGROUND Kidney transplantation is increasingly more common due to the ongoing shortage of deceased donors.However,anatomical challenges,such as a short renal artery,can complicate surgical procedures and increase complication risk,including thrombosis and anastomotic stenosis.To address these issues and optimize graft outcomes,innovative surgical techniques are essential.CASE SUMMARY We present a case of kidney transplantation complicated by a short donor renal artery.To address the discrepancy between arterial length and diameter mismatch,the recipient’s inferior epigastric artery was used as a cuff interposition for arterial reconstruction.Following standard laparoscopic donor nephrectomy,vascular reconstruction was performed on the back table.The use of the inferior epigastric artery as a cuff allowed for successful elongation and size matching of the donor renal artery,enabling a tension-free anastomosis to the recipient’s external iliac artery.Postoperative Doppler ultrasound and angiography confirmed excellent graft perfusion.The patient experienced an uneventful recovery with immediate graft function and maintained stable renal function at 6 months post-transplant.To our knowledge,this is the first reported use of the inferior epigastric artery as a cuff interposition in renal artery reconstruction,offering a novel and effective technique for managing short renal arteries in kidney transplantation.CONCLUSION Interposition of the epigastric artery offers an innovative technique for managing short donor renal arteries,reducing the risk of early thrombosis and long-term complications as size mismatch and intimal hyperplasia.展开更多
The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore how we can cope with the influence of short videos.
Short videos on social media have rapidly emerged as a powerful marketing tool for shaping consumer behavior.This comparative study investigates the impact of short videos on the purchasing behavior of young consumers...Short videos on social media have rapidly emerged as a powerful marketing tool for shaping consumer behavior.This comparative study investigates the impact of short videos on the purchasing behavior of young consumers(aged 18-35)in Hanoi and Taipei.Quantitative methods,including surveys,and experimental design,were employed in both cities,with a sample size of 200 respondents per location.Key influencing factors-including video content,product information,celebrity endorsement,viewer interaction,and perceived value-were systematically analyzed.The findings highlight both commonalities and contextual differences in how short videos influence purchasing behavior.This study offers practical implications for businesses and marketers targeting young consumers in Vietnam and Taiwan.展开更多
As a World Cultural Heritage site,the Beijing-Hangzhou Grand Canal has rich intangible cultural heritage(ICH)along its route.In the era of globalization and media convergence,using short videos to promote the canal’s...As a World Cultural Heritage site,the Beijing-Hangzhou Grand Canal has rich intangible cultural heritage(ICH)along its route.In the era of globalization and media convergence,using short videos to promote the canal’s ICH globally is important for internationalizing Chinese culture.This study uses cross-cultural communication theory,case analysis,and data research to examine the current status of short video dissemination of the canal’s ICH.It identifies core challenges in narrative techniques and cultural translation,and proposes a systematic optimization framework with five dimensions including content and platform.The findings offer both theoretical insights and practical guidance for the international promotion of ICH.展开更多
The associations of volatile organic compounds(VOCs)exposure with short sleep duration(SSD)have rarely been studied.We aimed to evaluate the correlation between VOC exposure and SSD risk,while also exploring the poten...The associations of volatile organic compounds(VOCs)exposure with short sleep duration(SSD)have rarely been studied.We aimed to evaluate the correlation between VOC exposure and SSD risk,while also exploring the potential mediating influence of depressive symptoms.Blood concentrations of seven VOCs,namely benzene,toluene,ethylbenzene,m-/p-xylene,o-xylene,styrene(collectively known as BTEXS),and 1,4-dichlorobenzene,were analyzed in 2905 U.S.adults.Weighted logistic regression,quantile-based g-computation(QGC),and weighted quantile sum(WQS)regression were employed to investigate associations between selected VOCs and SSD risk.Mediation analyses were conducted to explore the potential mediating effects of depressive symptoms on these relationships.Increased blood levels of BTEXS were positively correlated with SSD risk,with odds ratios(OR)ranging from 1.130 to 1.212(all P<0.05).A nonlinear association between toluene concentration and SSD risk was observed(P for nonlinearity=0.028).Both QGC and WQS analyses indicated a positive association between co-exposure to VOCs and SSD,with styrene showing the highest positive weights(QGC:OR=1.313,95%confidence interval(CI):1.038–1.660;WQS:OR=1.386,95%CI:1.111–1.731).Furthermore,BTEXS exposure was positively linked to depressive symptoms,which in turn were significantly associated with SSD risk.Mediation analyses revealed that depressive symptoms partially mediated the relationships between individual and mixed VOCs and SSD risk,with mediation proportions ranging from 15.87%to 20.54%(all P<0.05).These findings indicated that exposure to VOCs increased SSD risk,with depressive symptoms playing a partial mediating role.展开更多
BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axia...BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axial T1 and T2 sequences;however,these may miss certain pathologies.The addition of coronal short tau inversion recovery(STIR)sequences offers the potential to enhance the detection of both spinal and extra-spinal abnormalities,thereby improving clinical decisionmaking and patient outcomes.AIM To evaluate the impact of adding coronal STIR sequences to routine lumbar MRI in diagnosing back pain and sciatica.METHODS We prospectively analyzed data from patients aged 6 and older presenting with back pain or sciatica who underwent lumbar spine MRI at our institution.The standardized MRI protocol utilized included sagittal and axial T1 and T2 sequences,complemented by a coronal STIR sequence.Data on structural abnormalities were collected,reviewed,and analyzed using counts,percentages,and Fisher's exact test for categorical variables.RESULTS Our cohort comprised 274 patients(115 males,159 females;mean age 44.91 years).Notably,39 patients exhibited abnormalities across all sequences,while 72.63%showed normal findings on the coronal STIR sequence.Importantly,30.29%of cases were diagnosed as normal without the coronal STIR,and 36 patients with normal T1 and T2 sequences presented abnormalities on the coronal STIR.The coronal STIR sequence successfully identified 26 spinal and 10 non-spinal pathologies,including 17 cases of sacroiliitis,with a significant association(P<0.0001)between sacroiliitis diagnosis and abnormalities visible solely on this sequence.CONCLUSION Integrating coronal STIR into routine lumbar MRI enhances detection of hidden spinal and extra-spinal pathologies,improves patient management,and offers a cost-effective,practical upgrade with significant diagnostic and clinical value.展开更多
The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins o...The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins of periodic signals in GPS observations makes it difficult to isolate the millimeter-levelMTE displacement from other signals and noises.In this study,to assess the diurnal and semidiurnalsignals induced by MTE,we processed 12 very short GPS baselines(VSGB)with length<150 m.Themonument pairs for each baseline differ in their heights,horizontal structure,or base foundations.Meanwhile,two zero-baselines were also processed as the control group.Results showed that the sea-sonal signals observed in VSGB time series in the horizontal and vertical directions,were mainly inducedby seasonal MTE.Time-varying diurnal and semidiurnal signals with amplitude up to 4 mm wereobserved in the vertical direction for baselines with monument height difference(MHD)larger than10 m.Horizontal diurnal signal with an amplitude of about 2 mm was also detected for baselines withnon-axisymmetric monument structure.The orientation of the detected horizontal displacement wascoherent with the direction of daily temperature variation(DTV)driven by direct solar radiation,whichindicates that the diurnal and semidiurnal signals are likely induced by MTE.The observed high-frequency MTE displacements,if not well modeled and removed,may propagate into spurious long-term signals and bias the velocity estimation in the daily GPS time series.展开更多
High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique a...High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique applications.This paper details the successful commissioning of the 1 PW experimental area at the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)facility in Romania,using both of the available laser arms.The experimental setup featured a short focal parabolic mirror to accelerate protons through the target normal sheath acceleration mechanism.Detailed experiments were conducted using various metallic and diamond-like carbon targets to investigate the dependence of the proton acceleration on different laser parameters.Furthermore,the paper discusses the critical role of the laser temporal profil in optimizing proton acceleration,supported by hydrodynamic simulations that are correlated with experimental outcomes.The finding underscore the potential of the ELI-NP facility to advance research in laser–plasma physics and contribute significantl to high-energy physics applications.The results of this commissioning establish a strong foundation for experiments by future users.展开更多
Objective:To investigate the clinical efficacy and safety evaluation of Polyethylene Glycol Recombinant Human Growth Hormone Injection(PEG-rhGH)in the treatment of idiopathic short stature.Methods:A total of 1402 pati...Objective:To investigate the clinical efficacy and safety evaluation of Polyethylene Glycol Recombinant Human Growth Hormone Injection(PEG-rhGH)in the treatment of idiopathic short stature.Methods:A total of 1402 patients were enrolled from March 21,2024 to January 13,2025,including 778 males and 624 females,with ages mainly ranging from 5 to 13 years old.Follow-up visits were completed by 488 patients for the first time,174 patients for the second time,and 81 patients for the third time.All patients were treated with PEG-rhGH(Jin Sai Zeng)as the main therapy after admission.The changes in height information,IGF-1,and thyroid examination results of each patient at the initial diagnosis,6,9,and 12 months after treatment were observed and analyzed.Results:There was no statistical difference between the baseline and the initial diagnosis,as well as the second follow-up visit(P<0.05),while there was a statistical difference between the baseline and the first and third follow-up visits(P>0.05).There was a statistically significant difference in IGF-1 between the initial diagnosis and the first follow-up visit(P<0.05),but no statistical difference between the first,second,and third follow-up visits(P>0.05).Additionally,IGF-1 levels increased with time.There was no statistical difference in TSH between the initial diagnosis and the first,second,and third follow-up visits(P>0.05).There was a statistical difference in free T3 between the initial diagnosis and the first and second follow-up visits(P<0.05),but no statistical difference between the second and third follow-up visits(P>0.05).There was no statistical difference in free T4 between the initial diagnosis and the first and second follow-up visits(P>0.05),but there was a statistical difference between the second and third follow-up visits(P<0.05).Conclusion:PEG-rhGH(Jin Sai Zeng)is significantly effective in improving height and IGF-1 levels in patients with idiopathic short stature.展开更多
Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the cou...Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the country has a 6.5%prevalence of small-for-gestational-age(SGA),ranking fifth globally in total SGA birth numbers^([1,2]).展开更多
The pore size distribution is often an important parameter for transport processes in porous media.Cryoporometry experiments can provide such data in the meso and macropore size up to 1 mm providing the sample tempera...The pore size distribution is often an important parameter for transport processes in porous media.Cryoporometry experiments can provide such data in the meso and macropore size up to 1 mm providing the sample temperature is finely controlled.We use a Peltier based system inserted directly into the NMR probe to control the temperature within 0.05℃and impose temperature ramps down to 0.002℃/min,necessary to characterize the largest pore sizes.The pore size information in the macropore range cannot be obtained from gas adsorption techniques while mercury injection is questionable for the material considered here.For porous materials made of paramagnetic minerals such as lithium-iron phosphate(LiFePO_(4),LFP)or nickel-manganese-cobalt oxides(NMC)and saturated with octamethylcyclotetrasiloxane(OMCTS),the T_(2)relaxation times are very short such as protons from the liquid and frozen phases cannot be separated.Hence the usual cryoporometry experiment cannot be performed.Instead,we propose to use the T_(1)contrast to separate these phases.The method is studied in detail along with some temperature effects linked with the T_(1)variation of the bulk frozen OMCTS.We show an example on two cathode materials part of industrial battery product.展开更多
BACKGROUND Congenital short bowel syndrome(CSBS)is a rare disorder characterized by a congenital shortage in the length of the small intestines,resulting in compromised intestinal functionality,frequently accompanied ...BACKGROUND Congenital short bowel syndrome(CSBS)is a rare disorder characterized by a congenital shortage in the length of the small intestines,resulting in compromised intestinal functionality,frequently accompanied by congenital intestinal malrotation.This study summarizes the experience of enteral and parenteral nutrition(PN)schemes for two cases of CSBS accompanied by intestinal malrotation to provide a reference for this condition.CASE SUMMARY Case 1 underwent surgical intervention 23 days after birth,but experienced postoperative intolerance to oral feeding.Consequently,the patient was transitioned to nasal feeding for 6 months while concurrently receiving round-the-clock PN.Despite ongoing adjustments to the caloric intake of enteral and PN throughout the treatment,cholestatic liver injury persisted.Furthermore,this child developed malnutrition by the age of 1 year.Case 2 received surgical intervention on 2 days after birth,demonstrating favorable tolerance for enteral feeding and intermittent PN.The child exhibited satisfactory growth and development without any associated complications.CONCLUSION CSBS is rarely encountered in clinical practice and is often accompanied by congenital intestinal malrotation.It can be improved with early diagnosis and active surgical intervention.Thus,we recommend early initiation of total PN,which is a highly effective measure in promoting early growth and development.展开更多
基金supported by the International Joint Research Project of Huiyan International College,Faculty of Education,Beijing Normal University(Grant Number:ICER202102).
文摘Objectives:Short video addiction has emerged as a significant public health issue in recent years,with a growing trend toward severity.However,research on the causes and impacts of short video addiction remains limited,and understanding of the variable“TikTok brain”is still in its infancy.Therefore,based on the Stimulus-Organism-Behavior-Consequence(SOBC)framework,we proposed six research hypotheses and constructed a model to explore the relationships between short video usage intensity,TikTok brain,short video addiction,and decreased attention control.Methods:Given that students are considered a high-risk group for excessive short video use,we collected 1086 valid participants from Chinese student users,including 609 males(56.1%)and 477 females(43.9%),with an average participant age of 19.84 years,to test the hypotheses.Results:(1)Short video usage intensity was positively related to short video addiction,TikTok brain,and decreased attention control;(2)TikTok brain was positively related to short video addiction and decreased attention control;and(3)Short video addiction was positively related to decreased attention control.Conclusions:These findings suggest that although excessive use of short video applications brings negative consequences,users still spend significant amounts of time on these platforms,indicating a need for strict self-regulation of usage time.
文摘BACKGROUND Total hip arthroplasty(THA)has increased along with an increasing demand for improved quality of life.Combined with prolonged life expectancy,the number of revision surgeries is expected to increase.Stress shielding is a significant issue with traditional femoral stems used in THA,making revision surgeries particularly challenging in younger patients.This has sparked renewed interest in studying safety and functional outcomes of short metaphyseal femoral stems,which have the potential to alleviate these challenges and simplify revision surgeries.AIM To evaluate the long-term outcomes of short-stem THA.METHODS A total of 124 hips that underwent THA using the short femoral stem(TRILOCK®Depuy)between May 2006 and November 2008 were included in this study.Patients were followed for a period of 15 years.Outcomes were assessed in terms of pain relief,hip joint range of motion,improvement in mobility,and functional outcomes using the modified Harris Hip Score,Oxford hip score,and Western Ontario and McMaster Universities Osteoarthritis index score.RESULTS A total of 124 hips in 98 patients were evaluated.Significant improvements in functional outcomes were observed over the 15-year follow-up period,with no cases of subsidence,implant loosening,or complications necessitating revision surgery.The only complication reported was heterotopic ossification in 1 patient.CONCLUSION Short metaphyseal stems provide better functional outcomes with early mobilization,and its long-term follow-up without subsidence,implant loosening,or proximal femoral bone loss simplifies revision surgery in younger patients.
基金supported by the National Key R&D Program of China,No.2021YFC2501200(to PC).
文摘Short-chain fatty acids,metabolites produced by the fermentation of dietary fiber by gut microbiota,have garnered significant attention due to their correlation with neurodegenerative diseases,particularly Parkinson’s disease.In this review,we summarize the changes in short-chain fatty acid levels and the abundance of short-chain fatty acid-producing bacteria in various samples from patients with Parkinson’s disease,highlighting the critical role of gut homeostasis imbalance in the pathogenesis and progression of the disease.Focusing on the nervous system,we discuss the molecular mechanisms by which short-chain fatty acids influence the homeostasis of both the enteric nervous system and the central nervous system.We identify key processes,including the activation of G protein-coupled receptors and the inhibition of histone deacetylases by short-chain fatty acids.Importantly,structural or functional disruptions in the enteric nervous system mediated by these fatty acids may lead to abnormalα-synuclein expression and gastrointestinal dysmotility,which could serve as an initiating event in Parkinson’s disease.Furthermore,we propose that short-chain fatty acids help establish communication between the enteric nervous system and the central nervous system via the vagal nerve,immune circulation,and endocrine signaling.This communication may shed light on their potential role in the transmission ofα-synuclein from the gut to the brain.Finally,we elucidate novel treatment strategies for Parkinson’s disease that target short-chain fatty acids and examine the challenges associated with translating short-chain fatty acid-based therapies into clinical practice.In conclusion,this review emphasizes the pivotal role of short-chain fatty acids in regulating gut-brain axis integrity and their significance in the pathogenesis of Parkinson’s disease from the perspective of the nervous system.Moreover,it highlights the potential value of short-chain fatty acids in early intervention for Parkinson’s disease.Future research into the molecular mechanisms of short-chain fatty acids and their synergistic interactions with other gut metabolites is likely to advance the clinical translation of innovative short-chain fatty acid-based therapies for Parkinson’s disease.
基金National Key Research and Development Program(2021YFB3401101)。
文摘Short process forming techniques for brazing and soldering materials can shorten the process,improve product quality,and increase production efficiency,which has received much attention from welding researchers.This review mainly summarized the research reports on short process forming techniques for brazing and soldering materials.Firstly,the traditional process and its shortcomings were presented.Secondly,the latest research of short process forming technologies,such as continuous casting technique,atomization powder technique,solder ball forming technique,and rapid solidification technique,was summarized,and the traditional forming performance of several brazing and soldering materials was introduced.Finally,the current restrictions and research trends of short process forming technique for brazing and solder materials were put forward,providing theoretical guidance and reference for related research and technique development in brazing and soldering field.
基金supported by the National Natural Science Foundation of China(32172010)the Major Program of Guangdong Basic and Applied Basic Research(2019B030302006).
文摘Short tandem repeats(STRs)modulate gene expression and contribute to trait variation.However,a systematic evaluation of the genomic characteristics of STRs has not been conducted,and their influence on gene expression in rice remains unclear.Here,we construct a map of 137,629 polymorphic STRs in the rice(Oryza sativa L.)genome using a population-scale resequencing dataset.A genome-wide survey encompassing 4726 accessions shows that the occurrence frequency,mutational patterns,chromosomal distribution,and functional properties of STRs are correlated with the sequences and lengths of repeat motifs.Leveraging a transcriptome dataset from 127 rice accessions,we identify 44,672 expression STRs(eSTRs)by modeling gene expression in response to the length variation of STRs.These eSTRs are notably enriched in the regulatory regions of genes with active transcriptional signatures.Population analysis identifies numerous STRs that have undergone genetic divergence among different rice groups and 1726 tagged STRs that may be associated with agronomic traits.By editing the(ACT)_(7) STR in OsFD1 promoter,we further experimentally validate its role in regulating gene expression and phenotype.Our study highlights the contribution of STRs to transcriptional regulation in plants and establishes the foundation for their potential use as alternative targets for genetic improvement.
文摘In the wave of internet culture,short videos have become an indispensable medium for social communication.The metaphorical hot words contained within them serve as a unique linguistic phenomenon that leads topics and focuses attention,greatly enriching the expressive layers and rhetorical charm of short videos,and significantly enhancing the video’s theme orientation and emotional identification.This research aims to explore the relationship between the use of metaphorical Internet buzzwords in short videos and the thematic and emotional orientation.The study adopts a combination of qualitative and quantitative methods,taking 10 videos with over 10,000 likes posted by a well-known blogger on Xiaohongshu in 2024 as the research object,transcribing the text,forming research corpora,and conducting multi-dimensional cognitive analysis on them.The study shows that about half of short videos contain metaphorical hot words.Different types of metaphorical hot words can trigger different emotional reactions from fans,especially humorous metaphorical hot words that can stimulate fans’emotional identification and resonance.In addition,in terms of fan participation,videos using metaphorical hot words tend to attract more fan attention than those that do not:these videos not only attract more fans to watch and like,but also trigger more comments and sharing behaviors.In summary,short videos cleverly use metaphors to create internet hot words,significantly enhancing the video’s thematic guidance and emotional resonance,manifested in creating popular topics,clarifying guiding themes,enhancing content attractiveness,and stimulating strong emotional identification,thereby promoting interactive behaviors such as likes and shares.These findings provide a reference for research in related fields such as metaphor,communication studies,and sociology.
文摘Solar radiation data forecasting algorithms are important,especially in developing countries,as vast solar power plants cannot measure reliable and constant solar irradiance.The challenges of solar irradiance prediction may be resolved by machine learning using weather datasets.This study emphasises the daily and monthly global solar radiation data predictions of three locations,Pretoria,Bloemfontein,and Vuwani,at different provinces in South Africa with various solar radiation distributions.The study evaluated five different machine learning models.Forecasting models were established to evaluate global solar radiation,focusing on input data.The selected forecast models are centered on their ability to perform with time series data.These models use five years of data from meteorological parameters,such as global horizontal irradiance(GHI),relative humidity,wind speed and ambient temperature between 1 January 2018 and 31 December 2022.The datasets from these meteorological parameters are utilised for training and testing the employed algorithms,which are examined using five statistical metrics.Moreover,the inconsistency of the solar irradiance time series was equally assessed using the clearness index.The results from this study demonstrate that the R2 value recording 0.866 datasets in Bloemfontein of random forest algorithm presents the highest performance during the training processes for all models studied,while the random tree in Vuwani showed the lowest performance of R2 of 0.210 with other algorithms in testing processes.Additionally,the maximum solar radiation was found in December for both Pretoria and Bloemfontein,recorded as 5.347 and 5.844 kWh/m2/day,respectively,while it was 4.692 kWh/m2/day at Vuwani in January.Similarly,the average clearness index of 0.605,0.657 and 0.533 are obtained at Pretoria,Bloemfontein,and Vuwani,respectively.Among the three sites under study,the solar radiation and clearness index are higher in Bloemfontein.Therefore,the proposed algorithms could be used conveniently for short-and long-term solar power plants in South Africa.
文摘BACKGROUND Kidney transplantation is increasingly more common due to the ongoing shortage of deceased donors.However,anatomical challenges,such as a short renal artery,can complicate surgical procedures and increase complication risk,including thrombosis and anastomotic stenosis.To address these issues and optimize graft outcomes,innovative surgical techniques are essential.CASE SUMMARY We present a case of kidney transplantation complicated by a short donor renal artery.To address the discrepancy between arterial length and diameter mismatch,the recipient’s inferior epigastric artery was used as a cuff interposition for arterial reconstruction.Following standard laparoscopic donor nephrectomy,vascular reconstruction was performed on the back table.The use of the inferior epigastric artery as a cuff allowed for successful elongation and size matching of the donor renal artery,enabling a tension-free anastomosis to the recipient’s external iliac artery.Postoperative Doppler ultrasound and angiography confirmed excellent graft perfusion.The patient experienced an uneventful recovery with immediate graft function and maintained stable renal function at 6 months post-transplant.To our knowledge,this is the first reported use of the inferior epigastric artery as a cuff interposition in renal artery reconstruction,offering a novel and effective technique for managing short renal arteries in kidney transplantation.CONCLUSION Interposition of the epigastric artery offers an innovative technique for managing short donor renal arteries,reducing the risk of early thrombosis and long-term complications as size mismatch and intimal hyperplasia.
文摘The Double Take column looks at a single topic from an African and Chinese perspective.This month,we explore how we can cope with the influence of short videos.
文摘Short videos on social media have rapidly emerged as a powerful marketing tool for shaping consumer behavior.This comparative study investigates the impact of short videos on the purchasing behavior of young consumers(aged 18-35)in Hanoi and Taipei.Quantitative methods,including surveys,and experimental design,were employed in both cities,with a sample size of 200 respondents per location.Key influencing factors-including video content,product information,celebrity endorsement,viewer interaction,and perceived value-were systematically analyzed.The findings highlight both commonalities and contextual differences in how short videos influence purchasing behavior.This study offers practical implications for businesses and marketers targeting young consumers in Vietnam and Taiwan.
基金sponsored by the 2024 annual special research project on humanities exchange initiated by the Sino-Foreign Humanities Exchange Center of the Ministry of Education and the Sino-Foreign Humanities Exchange Research Institute in the cultural tourism industry(CCIPEWHLY2024034).
文摘As a World Cultural Heritage site,the Beijing-Hangzhou Grand Canal has rich intangible cultural heritage(ICH)along its route.In the era of globalization and media convergence,using short videos to promote the canal’s ICH globally is important for internationalizing Chinese culture.This study uses cross-cultural communication theory,case analysis,and data research to examine the current status of short video dissemination of the canal’s ICH.It identifies core challenges in narrative techniques and cultural translation,and proposes a systematic optimization framework with five dimensions including content and platform.The findings offer both theoretical insights and practical guidance for the international promotion of ICH.
文摘The associations of volatile organic compounds(VOCs)exposure with short sleep duration(SSD)have rarely been studied.We aimed to evaluate the correlation between VOC exposure and SSD risk,while also exploring the potential mediating influence of depressive symptoms.Blood concentrations of seven VOCs,namely benzene,toluene,ethylbenzene,m-/p-xylene,o-xylene,styrene(collectively known as BTEXS),and 1,4-dichlorobenzene,were analyzed in 2905 U.S.adults.Weighted logistic regression,quantile-based g-computation(QGC),and weighted quantile sum(WQS)regression were employed to investigate associations between selected VOCs and SSD risk.Mediation analyses were conducted to explore the potential mediating effects of depressive symptoms on these relationships.Increased blood levels of BTEXS were positively correlated with SSD risk,with odds ratios(OR)ranging from 1.130 to 1.212(all P<0.05).A nonlinear association between toluene concentration and SSD risk was observed(P for nonlinearity=0.028).Both QGC and WQS analyses indicated a positive association between co-exposure to VOCs and SSD,with styrene showing the highest positive weights(QGC:OR=1.313,95%confidence interval(CI):1.038–1.660;WQS:OR=1.386,95%CI:1.111–1.731).Furthermore,BTEXS exposure was positively linked to depressive symptoms,which in turn were significantly associated with SSD risk.Mediation analyses revealed that depressive symptoms partially mediated the relationships between individual and mixed VOCs and SSD risk,with mediation proportions ranging from 15.87%to 20.54%(all P<0.05).These findings indicated that exposure to VOCs increased SSD risk,with depressive symptoms playing a partial mediating role.
文摘BACKGROUND Back pain and sciatica are common complaints that often require imaging for accurate diagnosis and management.Conventional lumbar magnetic resonance imaging(MRI)protocols typically include sagittal and axial T1 and T2 sequences;however,these may miss certain pathologies.The addition of coronal short tau inversion recovery(STIR)sequences offers the potential to enhance the detection of both spinal and extra-spinal abnormalities,thereby improving clinical decisionmaking and patient outcomes.AIM To evaluate the impact of adding coronal STIR sequences to routine lumbar MRI in diagnosing back pain and sciatica.METHODS We prospectively analyzed data from patients aged 6 and older presenting with back pain or sciatica who underwent lumbar spine MRI at our institution.The standardized MRI protocol utilized included sagittal and axial T1 and T2 sequences,complemented by a coronal STIR sequence.Data on structural abnormalities were collected,reviewed,and analyzed using counts,percentages,and Fisher's exact test for categorical variables.RESULTS Our cohort comprised 274 patients(115 males,159 females;mean age 44.91 years).Notably,39 patients exhibited abnormalities across all sequences,while 72.63%showed normal findings on the coronal STIR sequence.Importantly,30.29%of cases were diagnosed as normal without the coronal STIR,and 36 patients with normal T1 and T2 sequences presented abnormalities on the coronal STIR.The coronal STIR sequence successfully identified 26 spinal and 10 non-spinal pathologies,including 17 cases of sacroiliitis,with a significant association(P<0.0001)between sacroiliitis diagnosis and abnormalities visible solely on this sequence.CONCLUSION Integrating coronal STIR into routine lumbar MRI enhances detection of hidden spinal and extra-spinal pathologies,improves patient management,and offers a cost-effective,practical upgrade with significant diagnostic and clinical value.
基金funded by the Independent Innovation Project of Changjiang Institute of Survey,Planning,Design and Research Corporation (CX2020Z32)supported by the National Natural Science Foundation of China (Grant Numbers42204006 and 42104028)the Open Fund of Hubei Luojia Laboratory (Grant Numbers 230100020 and 230100019)
文摘The monument thermal effect(MTE)displacements could result in periodical signals with several mil-limeters magnitudes in the vertical and horizontal GPS position time series.However,the interaction ofvarious origins of periodic signals in GPS observations makes it difficult to isolate the millimeter-levelMTE displacement from other signals and noises.In this study,to assess the diurnal and semidiurnalsignals induced by MTE,we processed 12 very short GPS baselines(VSGB)with length<150 m.Themonument pairs for each baseline differ in their heights,horizontal structure,or base foundations.Meanwhile,two zero-baselines were also processed as the control group.Results showed that the sea-sonal signals observed in VSGB time series in the horizontal and vertical directions,were mainly inducedby seasonal MTE.Time-varying diurnal and semidiurnal signals with amplitude up to 4 mm wereobserved in the vertical direction for baselines with monument height difference(MHD)larger than10 m.Horizontal diurnal signal with an amplitude of about 2 mm was also detected for baselines withnon-axisymmetric monument structure.The orientation of the detected horizontal displacement wascoherent with the direction of daily temperature variation(DTV)driven by direct solar radiation,whichindicates that the diurnal and semidiurnal signals are likely induced by MTE.The observed high-frequency MTE displacements,if not well modeled and removed,may propagate into spurious long-term signals and bias the velocity estimation in the daily GPS time series.
基金supported by the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)PhaseⅡa project co-finance by the Romanian Government and the European Union through the European Regional Development Fund,by the Romanian Ministry of Education and Research CNCS-UEFISCDI(Project No.PN-ⅡIP4-IDPCCF-2016-0164)+1 种基金Nucleu Projects(Grant No.PN 23210105 and 19060105)supports ELI-NP through IOSIN funds as a Facility of National Interest。
文摘High-power laser systems have opened new frontiers in scientifi research and have revolutionized various scientifi fields offering unprecedented capabilities for understanding fundamental physics and allowing unique applications.This paper details the successful commissioning of the 1 PW experimental area at the Extreme Light Infrastructure–Nuclear Physics(ELI-NP)facility in Romania,using both of the available laser arms.The experimental setup featured a short focal parabolic mirror to accelerate protons through the target normal sheath acceleration mechanism.Detailed experiments were conducted using various metallic and diamond-like carbon targets to investigate the dependence of the proton acceleration on different laser parameters.Furthermore,the paper discusses the critical role of the laser temporal profil in optimizing proton acceleration,supported by hydrodynamic simulations that are correlated with experimental outcomes.The finding underscore the potential of the ELI-NP facility to advance research in laser–plasma physics and contribute significantl to high-energy physics applications.The results of this commissioning establish a strong foundation for experiments by future users.
文摘Objective:To investigate the clinical efficacy and safety evaluation of Polyethylene Glycol Recombinant Human Growth Hormone Injection(PEG-rhGH)in the treatment of idiopathic short stature.Methods:A total of 1402 patients were enrolled from March 21,2024 to January 13,2025,including 778 males and 624 females,with ages mainly ranging from 5 to 13 years old.Follow-up visits were completed by 488 patients for the first time,174 patients for the second time,and 81 patients for the third time.All patients were treated with PEG-rhGH(Jin Sai Zeng)as the main therapy after admission.The changes in height information,IGF-1,and thyroid examination results of each patient at the initial diagnosis,6,9,and 12 months after treatment were observed and analyzed.Results:There was no statistical difference between the baseline and the initial diagnosis,as well as the second follow-up visit(P<0.05),while there was a statistical difference between the baseline and the first and third follow-up visits(P>0.05).There was a statistically significant difference in IGF-1 between the initial diagnosis and the first follow-up visit(P<0.05),but no statistical difference between the first,second,and third follow-up visits(P>0.05).Additionally,IGF-1 levels increased with time.There was no statistical difference in TSH between the initial diagnosis and the first,second,and third follow-up visits(P>0.05).There was a statistical difference in free T3 between the initial diagnosis and the first and second follow-up visits(P<0.05),but no statistical difference between the second and third follow-up visits(P>0.05).There was no statistical difference in free T4 between the initial diagnosis and the first and second follow-up visits(P>0.05),but there was a statistical difference between the second and third follow-up visits(P<0.05).Conclusion:PEG-rhGH(Jin Sai Zeng)is significantly effective in improving height and IGF-1 levels in patients with idiopathic short stature.
基金funded by the Natural Science Foundation of Hunan Province(grant number 2024JJ5283 to XH)。
文摘Preterm birth and suboptimal fetal growth remain significant perinatal challenges worldwide.Recent data indicate that China's perinatal profile has improved due to reductions in preterm birth rates.However,the country has a 6.5%prevalence of small-for-gestational-age(SGA),ranking fifth globally in total SGA birth numbers^([1,2]).
文摘The pore size distribution is often an important parameter for transport processes in porous media.Cryoporometry experiments can provide such data in the meso and macropore size up to 1 mm providing the sample temperature is finely controlled.We use a Peltier based system inserted directly into the NMR probe to control the temperature within 0.05℃and impose temperature ramps down to 0.002℃/min,necessary to characterize the largest pore sizes.The pore size information in the macropore range cannot be obtained from gas adsorption techniques while mercury injection is questionable for the material considered here.For porous materials made of paramagnetic minerals such as lithium-iron phosphate(LiFePO_(4),LFP)or nickel-manganese-cobalt oxides(NMC)and saturated with octamethylcyclotetrasiloxane(OMCTS),the T_(2)relaxation times are very short such as protons from the liquid and frozen phases cannot be separated.Hence the usual cryoporometry experiment cannot be performed.Instead,we propose to use the T_(1)contrast to separate these phases.The method is studied in detail along with some temperature effects linked with the T_(1)variation of the bulk frozen OMCTS.We show an example on two cathode materials part of industrial battery product.
文摘BACKGROUND Congenital short bowel syndrome(CSBS)is a rare disorder characterized by a congenital shortage in the length of the small intestines,resulting in compromised intestinal functionality,frequently accompanied by congenital intestinal malrotation.This study summarizes the experience of enteral and parenteral nutrition(PN)schemes for two cases of CSBS accompanied by intestinal malrotation to provide a reference for this condition.CASE SUMMARY Case 1 underwent surgical intervention 23 days after birth,but experienced postoperative intolerance to oral feeding.Consequently,the patient was transitioned to nasal feeding for 6 months while concurrently receiving round-the-clock PN.Despite ongoing adjustments to the caloric intake of enteral and PN throughout the treatment,cholestatic liver injury persisted.Furthermore,this child developed malnutrition by the age of 1 year.Case 2 received surgical intervention on 2 days after birth,demonstrating favorable tolerance for enteral feeding and intermittent PN.The child exhibited satisfactory growth and development without any associated complications.CONCLUSION CSBS is rarely encountered in clinical practice and is often accompanied by congenital intestinal malrotation.It can be improved with early diagnosis and active surgical intervention.Thus,we recommend early initiation of total PN,which is a highly effective measure in promoting early growth and development.
