Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the J...Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.展开更多
Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased ph...Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased physical activity(PA)are important contributors to the rising prevalence of DM.This article reviews the research progress on the pathogenesis of DM,the effects of SB and PA on the risk of DM,aiming to explore the influence of different PA intensities,amounts,frequencies,durations and types on the incidence of DM.Research has shown that blood glucose levels tend to increase with the prolongation of SB.Within a certain range,PA intensity and PA amount are negatively correlated with the risk of DM;Performing PA for more than 3 days per week maintains normal glucose tolerance and lower blood pressure;Engaging in 150–300 min of moderate intensity exercise or 75–150 min of high-intensity exercise per week reduces the risk of DM;PA during leisure time reduces the risk of DM,while PA during work increases the risk of DM;Both aerobic training and resistance training reduce the risk of DM,and the combination of the two training methods produces better benefits;Various types of exercises,such as cycling,soccer,aerobics,yoga,tai chi,all reduce the risk of DM.In summary,prolonged SB increases the risk of DM,while appropriate PA reduces the risk of DM.As the intensity,amount,and frequency of PA increase,the effect of reducing DM risk becomes more significant.Different exercise methods have different effects on reducing DM risk.展开更多
Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(...Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and sleep.In particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely addressed.Methods:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank participants.Incident cases were determined by self-report or health care data according to RomeⅣcriteria.Results:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were recorded.When examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS risk.The isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS risk.Among people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,respectively.For people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,respectively.These benefits were mostly independent of genetic risk for IBS.Conclusion:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.展开更多
A new health concern in recent periods has seen the evolution of uncertain sedentary behavior.Remaining sedentary for extended durations is regarded as a notable hazard across various adult age brackets,especially the...A new health concern in recent periods has seen the evolution of uncertain sedentary behavior.Remaining sedentary for extended durations is regarded as a notable hazard across various adult age brackets,especially the excessive dependence on automobiles for transportation.Throughout the active period,monitoring seating habits has been made easier by sensors.Nevertheless,there exists a disagreement among professionals regarding the most suitable quantifiable criteria for encompassing the comprehensive data on sedentary behavior throughout the day.Owing to variations in measurement methodologies,data analysis approaches,and the lack of essential outcome indicators such as the total sedentary duration,the assessment of sedentary patterns in numerous research investigations was considered unfeasible.The research suggested fleeting granularity distinguish occurrences of regular human activities.Sophisticated units(essential cells) acquire multivariate transitory information.Frequent Behavior Patterns(FBPs) can be identified with a estimation of timeframe using our proposed scalable algorithms that employ collected widespread multivariate data(fleeting granularity).The research outcome,supported by rigorous analyses on two validated datasets,mark a significant progression.In the final stages of the study,a stacked Long Short-Term Memory(LSTM) model was utilized to replicate and forecast repetitive sedentary behavior patterns,leveraging data from the preceding six-hour window blocks of sedentary activity.The model effectively replicated state traits,previous action sequences,and duration,attaining an impressive 99% accuracy level as assessed through RMSE,MSE,MAPE,and r-correlation metrics.展开更多
Objective This study was aimed at examining the trends and correlates of physical activity(PA)and sedentary behaviors among Chinese children.Methods A total of 4,341 subjects(6,936 observations)aged 6–17 years who pa...Objective This study was aimed at examining the trends and correlates of physical activity(PA)and sedentary behaviors among Chinese children.Methods A total of 4,341 subjects(6,936 observations)aged 6–17 years who participated in the China Health and Nutrition Survey(2004–2015)were included.Of the subjects,41%participated in the survey twice or more.Random-effects ordinal regression models and repeated-measures mixed-effects models were used to examine the PA trends.Quantile regression models were applied to examine the factors influencing PA and sedentary behaviors.Results From 2004 to 2015,the prevalence of physical inactivity among Chinese children aged 6–17 years increased by 5.5%[odds ratio(OR),1.51;95%confidence interval(CI),1.19–1.90;P<0.001].The PA volume declined by 5.8 metabolic equivalent of task-hr/week(P<0.001),and the time spent in sedentary behaviors increased by 1.8 hr/week(P<0.001).Age,ethnicity,and region showed significant effects on the PA volume across the quartiles(P<0.001).Across the quartiles,sedentary time was significantly higher in the children residing in urban areas(P<0.001)or areas with high urbanization levels(P≤0.005)than in their counterparts.Conclusions A declining PA trend among Chinese children aged 6–17 years was observed from 2004 to2015,and certain subgroups and geographical areas are at higher risk of physical inactivity.展开更多
Diabetes is a leading chronic disease of childhood and adolescence. In addition to the well-known auto-immune, insulin-dependent diabetes mellitus （type 1 diabetes （T 1D））, the past two decades have witnessed the ...Diabetes is a leading chronic disease of childhood and adolescence. In addition to the well-known auto-immune, insulin-dependent diabetes mellitus （type 1 diabetes （T 1D））, the past two decades have witnessed the emergence of type 2 diabetes （T2D） in children and adolescents, which previously was only seen in middle-aged or older adults. One of the key components of diabetes management is physical activity （PA）. The beneficial effects of increased PA and decreased sedentary behavior are extremely important in youth with diabetes because of the markedly increased long-term risk of cardiovascular disease in this population compared to persons without diabetes. This review aims to comprehensively summarize the epidemiologic, observational research published and listed in PubMed between 1970 and 2012 on PA and sedentary behaviors, as well as physical fitness in children and adolescents with T1D and T2D. Additionally, we describe briefly the state of knowledge on perceived barriers of PA in persons with diabetes, with a focus on hypoglycemia. Finally, we provide an overview of the epidemiological literature pertaining to health benefits of increased PA in youth with TID and T2D and briefly discuss the topic of exercise-related hypoglycemia, Copyright ~ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.展开更多
Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study a...Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death.展开更多
Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined th...Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and mortality.We further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical activities.Methods:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to evaluation.Apolipoprotein E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this study.Results:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were recorded.In comparison to participants with leisure-time SB<5 h/day,the hazard ratio((HR),95%confidence interval(95%CI))of dementia incidence was 1.07(1.02-1.13)for 5-8 h/day and 1.25(1.13-1.38)for>8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects<60 years than in those>60 years(HR=1.26,95%CI:1.00-1.58 vs.HR=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk and 9%decreased mortality from dementia,with exercise(e.g.,swimming,cycling,aerobics,bowling)showing the strongest benefit(HR=0.82,95%CI:0.78-0.86 and HR=0.79,95%CI:0.72-0.86).Compared with APOEε4 noncarriers,APOEε4 carriers are more likely to see a decrease in Alzheimer’s disease incidence and mortality when PA is substituted for SB.Conclusion:Leisure-time SB was positively associated with the risk of dementia incidence and mortality.Replacing sedentary time with equal time spent doing PA may be associated with a significant reduction in dementia incidence and mortality risk.展开更多
Regular physical activity benefits the health of the general population, more in those with sedentary behaviors. PURPOSE： To verify the impact of adding leisure-time activities to the existed sedentary behaviors. MET...Regular physical activity benefits the health of the general population, more in those with sedentary behaviors. PURPOSE： To verify the impact of adding leisure-time activities to the existed sedentary behaviors. METHODS： A cross-sectional and a longitudinal analysis were undertaken in an ongoing epidemiological study （＂Move for Health＂） conducted by this Institution. The longitudinal study comprised 1572 subjects older than 35 yrs （53.8 ± 11.1 yrs, 76% women） enrolled during the period of 2004 to 2015. After a baseline assessment, the participants were submitted to a 10-week program of supervised physical exercises training and dietary counseling. The physical exercise protocol was composed by daily sessions （100 min）, 3-5x/wk, including warm up/stretching （20min）, 30 rain walking （60%-80% VO2max）, 40min strength in academy （3x 8-12 rep, 60%-70% 1RM） and stretching and cool down （10 min）. By using the International Physical Activity Questionnaire （IPAQ-way long-version 8）, it was evaluated the time spent on sedentary activities during the week and on weekends （h/day）, in the domains of sedentary transport （h/week） and physical leisure activities （h/week） at baseline （M0） and after 10 weeks （MI） of physical intervention. The Student＇s t test was used to compare moments with a significance level of 5%. RESULTS： I was shown that 18.3% presented lower values than 150 min/wk of physical activity. Lower quartile of leisure domain on weekdays along with more sedentary behavior on weekends were determined by socioeconomic characteristics such as lower income and schooling. The sample referred low income （71% earning less than 5 minimum salary wage）, low schooling （52.6% uncompleted elementary school） but in a good-excellent status of health, according their self-perception. Leisure time-physical activity increased 2.12 （P 〈 0.001）. Behaviors of sedentary transport and sitting time either weekdays or weekends did not change significantly （P 〉 0.05）. CONCLUSION： An inexpensive and institutional-conducted lifestyle modification program like the ＂Move for Health＂ can provide extra energy expenditure, as leisure time, to a low socioeconomic community. However, it has been unsuccessfully proved to change other existing sedentary behavior.展开更多
Summary What is already known on this topic?Physical activity(PA)and sedentary behavior(SB)are crucial determinants of both physical and mental health outcomes.However,large-scale studies using objective measurements ...Summary What is already known on this topic?Physical activity(PA)and sedentary behavior(SB)are crucial determinants of both physical and mental health outcomes.However,large-scale studies using objective measurements of these behaviors have not been widely implemented across China.展开更多
Background:Physical activity,sedentary behavior(SB),and sleep duration are associated with brain health.Effects of those on developing Parkinson’s disease(PD)are poorly investigated.This study aimed to examine the in...Background:Physical activity,sedentary behavior(SB),and sleep duration are associated with brain health.Effects of those on developing Parkinson’s disease(PD)are poorly investigated.This study aimed to examine the independent and joint associations of physical activity,SB,sleep with PD risk.Methods:We analyzed data on 401,697 participants from the UK Biobank cohort,which was enrolled in 2006–2010.Physical activities were measured based on a questionnaire.Sleep and SB time were defined through self-reported total number of hours.Models fitted with restricted cubic spline were conducted to test for linear and non-linear shapes of each association.Cox proportional hazards regression models were used to estimate the association of three modifiable behaviors.Results:Our analytic sample included 401,697 participants with 3030 identified cases of PD(mean age,63 years;62.9%male).PD risk was 18%lower in the high total physical activity group(95%CI,0.75–0.90),22%lower in the high leisure-time physical activity(LTPA)group(95%CI,0.71–0.86)compared with the low level and 14%higher in the high sleep duration group(95%CI,1.05–1.24)compared to moderate group.Total SB time was irrelevant with PD risk,while high TV viewing showed a 12%increase of PD risk compared to the low group(95%CI,1.02–1.22).Low computer use(0 h/day)was associated with a 14%higher risk compared to 1 h/day use(95%CI,1.04–1.26).Those associations were independent.A combination of 7 h/day sleep,moderate-to-high computer use,and moderate-to-vigorous intensity of LTPA showed lowest PD risk(HR,0.70;95%CI,0.57–0.85).Conclusions:Physical activity,SB,and sleep were associated with PD risks separately.Our findings emphasize the possibility for changing these three daily activities concurrently to lower the risk of PD.These findings may promote an active lifestyle for PD prevention.展开更多
Summary What is already known about this topic?The prevalence of insufficient physical activity(PA)among Chinese adults has shown an upward trend,reaching 22.3%in 2018.Leisure time PA(LTPA)constitutes a minimal propor...Summary What is already known about this topic?The prevalence of insufficient physical activity(PA)among Chinese adults has shown an upward trend,reaching 22.3%in 2018.Leisure time PA(LTPA)constitutes a minimal proportion of total physical activity patterns.展开更多
Background Physical activity(PA)is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus(T2DM)and prediabetes,but existing evidence relies mainly on self-reported measurements.We a...Background Physical activity(PA)is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus(T2DM)and prediabetes,but existing evidence relies mainly on self-reported measurements.We aimed to describe the intensity-specific dose-response associations of PA and sedentary behavior(SB)with macrovascular and microvascular events among individuals with T2DM and prediabetes.Methods This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank.PA,including total PA,moderate-to-vigorous intensity PA(MVPA),light-intensity PA(LPA),and SB,were measured by accelerometers over 7 days.MVPA was categorized according to the American Diabetes Association guideline-recommended level(at least 150 min/week),and total PA,LPA,and SB were grouped by tertiles.The outcomes were incidences of macrovascular events,microvascular events,heart failure(HF),and their combination(composite events).The events were ascertained using the International Classification of Diseases-10(ICD-10)codes on the hospital or death records.Results During a median follow-up of 6.8 years,1680 cases were documented,including 969 macrovascular events,839 microvascular events,and 284 incidents of HF.Accelerometer-measured PA,irrespective of intensity,was inversely associated with the risk of composite events and each outcome in the dose-response patterns.Regarding categorized PA,engagement in total PA(high vs.low)was associated with decreased risk of macrovascular events(hazard ratio(HR)=0.80;95%confidence interval(95%CI):0.67-0.95),microvascular events(HR=0.76;95%CI:0.63-0.93),and HF(HR=0.46;95%CI:0.32-0.66).Adherence to MVPA,but not LPA,above the guideline-recommended level(at least 150 min/week)was associated with reduced risk of macrovascular events(HR=0.80;95%CI:0.68-0.95),microvascular events(HR=0.76;95%CI:0.63-0.92),and HF(HR=0.65;95%CI:0.46-0.92).The minimum dose of MVPA for lowering the risk of composite events was approximately 59.0 min/week.More time spent in SB was associated with an increased risk of composite events(high vs.low,HR=1.17;95%CI:1.02-1.35)and HF(high vs.low,HR=1.54;95%CI:1.09-2.20).Replacement of 30 min of SB(HR=0.73;95%CI:0.65-0.81)and LPA(HR=0.74;95%CI:0.66-0.83)with MVPA dramatically reduced the risk of composite events.Conclusion Adherence to a higher amount of accelerometer-measured PA,especially MVPA at least 59 min/week,is associated with reduced risks of macrovascular and microvascular events among individuals with T2DM and prediabetes.Replacement of SB and LPA with MVPA helped lower the risk of diabetic vascular events.展开更多
Vasovagal syncope(VVS),which is triggered by physical exertion,is typically observed in athletes or patients with structural heart disease.There have been few reported cases among sedentary individuals.This case repor...Vasovagal syncope(VVS),which is triggered by physical exertion,is typically observed in athletes or patients with structural heart disease.There have been few reported cases among sedentary individuals.This case report details the experience of a 42-year-old sedentary woman who fainted during a treadmill stress test.Despite the absence of abnormalities in baseline cardiac and neurological evaluations,the patient exhibited sinus arrest(lasting 5–12 seconds)with significant ST-segment depression during haemodynamic collapse.Comprehensive assessments,incorporating coronary angiography,echocardiography,cranial computed tomography(CT),and biochemical testing,excluded the presence of structural or ischemic heart disease,arrhythmogenic syndromes,and cerebrovascular disorders.A Calgary Syncope Symptom Score of 3 confirmed the diagnosis of VVS,a diagnosis that was further substantiated by the patient’s symptoms resolving spontaneously when she was positioned supine.This case demonstrates that exercise-induced syncope can occur in individuals who are physically unfit and have no cardiac abnormalities.Transient ST-segment changes in such cases reflect autonomic nervous system dysfunction rather than myocardial ischaemia.It is incumbent upon clinicians to consider a neurocardiogenic mechanism in sedentary patients presenting with exertional syncope despite a negative standard cardiac evaluation.展开更多
Although emerging studies from high-income countries investigated the relationship between sedentary behavior(SB) and cardiovascular risk,little evidence came from developing countries.Moreover,the benefits of realloc...Although emerging studies from high-income countries investigated the relationship between sedentary behavior(SB) and cardiovascular risk,little evidence came from developing countries.Moreover,the benefits of reallocating time from SB to physical activity(PA) on incident cardiovascular disease(CVD) are unknown.Using three cohorts from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project,we included 93 110 adults who were free from CVD at baseline.Cox proportional hazards models were used to calculate the hazard ratios(HRs) and 95% confidence intervals(CIs) for CVD,including stroke,coronary heart disease,and CVD death.Isotemporal substitution models were applied to estimate the per-hour effects of replacing SB with PA.After 5.8 years follow-up,3799 CVD cases were identified.A gradient positive association between sedentary time and incident CVD was observed.Relative to those with <5 h/d sedentary time,the multivariable-adjusted HRs(95% CIs) of CVD incidence were 1.07(0.96-1.20),1.27(1.13-1.43) and 1.51(1.34-1.70) for those having 5-<8,8-<10,and> 10 h/d sedentary time,respectively.When participants were cross-classified by SB and moderate to vigorous physical activity(MVPA) level,the CVD risk was highest in those with> 10 h/d SB and <150 min/week MVPA.Among those who reported> 5 h/d sedentary time,per-hour substitution of SB with light,moderate,and vigorous PA reduced incident CVD risk by 5%,6%,and 8%,respectively.The study first found that sedentary time was associated with increased incident CVD risk among Chinese adults and that substitution of SB with PA of any intensity could convey cardiovascular benefits among those with> 5 h/d SB.展开更多
The aim of the present study was to investigate the relationship of dynapenia combined with sedentary behavior(SB)on the risk of mortality in older adults living in a Brazilian community.A total of 322 participants ag...The aim of the present study was to investigate the relationship of dynapenia combined with sedentary behavior(SB)on the risk of mortality in older adults living in a Brazilian community.A total of 322 participants aged60 years from the ELSIA(Longitudinal Study of Elderly Health in Alcobaça)prospective cohort were included.Dynapenia was diagnosed when the handgrip strength was<27 kg for men and<16 kg for women.The exposure time to SB was assessed considering the total time spent sitting during one day in the week and one day on the weekend.When combined with dynapenia,we derived the construction of four groups:best behavior(absence of dynapenia and low SB),intermediate behavior(absence of dynapenia and high SB;presence of dynapenia and low SB)and worst behavior(presence of dynapenia and high SB).Mortality was assessed by the follow-up time until death and/or censorship.During the 5-year follow-up of the study,55 participants progressed to death.In the adjusted models,the dynapenia and the time spent exposed to SB were analyzed in a combined way,the older adults with worse behavior(high SB and dynapenia)had higher risk ratios for mortality(hazard ratio 2.46;95%confidence interval 1.01–5.97)than the best behavior group.Older adults with dynapenia are at greater risk for all-cause mortality,which is aggravated by the addition of longer exposure to SB.展开更多
Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent...Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern China.Methods:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 years.Baseline self-reported PA and SB were collected via the questionnaire.Kaplan–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause mortality.Results:A total of 11,744 eligible participants were included in the analysis.Over an average of 5.4 years of follow-up,796 deaths occurred.The risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause mortality.Participants with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.展开更多
Objective:This study was conducted to explore the relationships among sedentary behavior(SB),electronic product addiction(EPA),and depression(D)in adolescents during the COVID-19 epidemic.Methods:A total of 604 adoles...Objective:This study was conducted to explore the relationships among sedentary behavior(SB),electronic product addiction(EPA),and depression(D)in adolescents during the COVID-19 epidemic.Methods:A total of 604 adolescents(including 309 girls and 295 boys aged 12-18)were selected from Qufu City,Shandong Province,China for three rounds of investigation.The model was constructed using AMOS 23.0 software,and cross-lagged analysis was conducted.Results:SB at T1 can significantly positively predict SB and EPA at T2(p<0.05).EPA at T1 can significantly positively predict SB and D at T2(p<0.05).Physical activity level and SB at T2 can significantly predict SB and EPA at T3(p<0.05).EPA at T2 can significantly predict SB,EPA,and D at T3(p<0.05).Conclusions:SB and EPA are predictive factors for D.Moreover,SB can significantly positively predict D and indirectly predict D through the mediating effect of EPA.展开更多
Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting dis...Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting disrupts the circulation of qi and blood,damages muscles,impairs spleen function,and ultimately leads to diseases.Modern biomedical evidence shows that sedentary behavior,including prolonged sitting,affects endocrine,metabolic,and physiological functions,increasing the risk of chronic diseases.This article systematically reviews TCM records of the health impacts of long-time sitting and biomedical findings,to explore the pathophysiological mechanisms underlying the health risks of prolonged sitting.By integrating TCM's preventative philosophy,namely Zhi Wei Bing(治未病preventing a disease before it arises),with modern preventive medicine,this study offers insights into strategies for mitigating the health risks associated with sedentary behavior.展开更多
Background:Grounded in intersectionality theory,this study examined the 6-year prevalence trend and correlates in meeting Canada’s 24-Hour Movement Guidelines(Guidelines hereafter)in a nationally representative adole...Background:Grounded in intersectionality theory,this study examined the 6-year prevalence trend and correlates in meeting Canada’s 24-Hour Movement Guidelines(Guidelines hereafter)in a nationally representative adolescent samples of South Korea(officially the Republic of Korea).Methods:Self-reported,annually repeated cross-sectional data collected between 2013 and 2018 were used(n=372,433,12-17 years old,47.9%females).Adolescents were categorized as meeting or not meeting different sets of physical activity,screen time(ST),and sleep recommendations within the Guidelines,separately for weekdays and weekend days.Intersectional correlates included sex and social class(i.e.,family economic status,parental education level,and academic performance).Multiple logistic regression analyses were performed.Results:Overall,the proportion of adolescents meeting physical activity,ST,and sleep recommendations were 5.3%,60.3%,and 10.2%on weekdays and 5.3%,28.2%,and 46.4%on weekend days,respectively.Between 2013 and 2018,no substantial changes were observed for meeting the physical activity or sleep recommendation,while meeting the ST recommendation was markedly lower in 2018.The proportion of meeting all 3 recommendations were 0.5%for weekdays and 0.8%for weekend days.Overall,compared to female adolescents,male adolescents were consistently associated with more favorable patterns of meeting different sets of recommendations,regardless of social class.Among females only,social class appeared to be not important or even detrimental in meeting different sets of recommendations.Being male,compounded with social class,was associated with meeting the ST recommendation.Conclusion:Less than 1%of Korean adolescents met the overall Guidelines.Intersectionality-based analysis and intervention may be important in promoting healthy active lifestyles among South Korean adolescents.展开更多
文摘Type 2 diabetes(T2D)is an insidious disease associated with neural and vascular complications,acceleration of cardiovascular disease,changes in heart function,and premature death.In the newly released article of the Journal of Sport and Health Science,Liang et al.1 describe results from the UK Biobank data showing the benefits of moderate-to-vigorous intensity physical activity(MVPA)on reducing the risks for vascular events in 11,474 adults with T2D and prediabetes.
基金Key Project of Undergraduate Teaching Reform Research of Shandong Normal University(No.2024ZJ12)sixth batch of"Sports and Health"special topic of Education Research of Chinese Society of Education。
文摘Diabetes mellitus(DM)has become one of the most serious and common chronic diseases around the world,leading to various complications and a reduction in life expectancy.Increased sedentary behavior(SB)and decreased physical activity(PA)are important contributors to the rising prevalence of DM.This article reviews the research progress on the pathogenesis of DM,the effects of SB and PA on the risk of DM,aiming to explore the influence of different PA intensities,amounts,frequencies,durations and types on the incidence of DM.Research has shown that blood glucose levels tend to increase with the prolongation of SB.Within a certain range,PA intensity and PA amount are negatively correlated with the risk of DM;Performing PA for more than 3 days per week maintains normal glucose tolerance and lower blood pressure;Engaging in 150–300 min of moderate intensity exercise or 75–150 min of high-intensity exercise per week reduces the risk of DM;PA during leisure time reduces the risk of DM,while PA during work increases the risk of DM;Both aerobic training and resistance training reduce the risk of DM,and the combination of the two training methods produces better benefits;Various types of exercises,such as cycling,soccer,aerobics,yoga,tai chi,all reduce the risk of DM.In summary,prolonged SB increases the risk of DM,while appropriate PA reduces the risk of DM.As the intensity,amount,and frequency of PA increase,the effect of reducing DM risk becomes more significant.Different exercise methods have different effects on reducing DM risk.
基金supported by grants from China CDC Key Laboratory of Environment and Population Health(2022-CKL-03)Peking University(BMU2021YJ044)supported by the General Program of National Natural Science Foundation of China(32170898)。
文摘Background:Irritable bowel syndrome(IBS)substantially affects quality of life and requires early prevention.This study aimed to elucidate the relationships between IBS and daily behaviors,including sedentary behavior(SB),physical activity(PA),and sleep.In particular,it seeks to identify healthy behaviors to reduce IBS risk,which previous studies have rarely addressed.Methods:Daily behaviors were retrieved from self-reported data of 362,193 eligible UK Biobank participants.Incident cases were determined by self-report or health care data according to RomeⅣcriteria.Results:A total of 345,388 participants were IBS-free at baseline,during a median follow-up of 8.45 years,19,885 incident IBS cases were recorded.When examined individually,SB and shorter(≤7 h/day)or longer(>7 h/day)sleep duration were each positively associated with increased IBS risk,and PA was associated with lower IBS risk.The isotemporal substitution model suggested that replacing SB with other activities could provide further protective effects against IBS risk.Among people sleeping≤7 h/day,replacing 1 h of SB with equivalent light PA,vigorous PA,or sleep was associated with 8.1%(95%confidence interval(95%CI):0.901-0.937),5.8%(95%CI:0.896-0.991),and 9.2%(95%CI:0.885-0.932)reduced IBS risk,respectively.For people sleeping>7 h/day,light and vigorous PA were associated with a 4.8%(95%CI:0.926-0.978)and a 12.0%(95%CI:0.815-0.949)lower IBS risk,respectively.These benefits were mostly independent of genetic risk for IBS.Conclusion:SB and unhealthy sleep duration are risk factors for IBS.A promising way to mitigate IBS risk for individuals sleeping≤7 h/day and for those sleeping>7 h/day appears to be by replacing SB with adequate sleep or vigorous PA,respectively,regardless of the genetic predisposition of IBS.
文摘A new health concern in recent periods has seen the evolution of uncertain sedentary behavior.Remaining sedentary for extended durations is regarded as a notable hazard across various adult age brackets,especially the excessive dependence on automobiles for transportation.Throughout the active period,monitoring seating habits has been made easier by sensors.Nevertheless,there exists a disagreement among professionals regarding the most suitable quantifiable criteria for encompassing the comprehensive data on sedentary behavior throughout the day.Owing to variations in measurement methodologies,data analysis approaches,and the lack of essential outcome indicators such as the total sedentary duration,the assessment of sedentary patterns in numerous research investigations was considered unfeasible.The research suggested fleeting granularity distinguish occurrences of regular human activities.Sophisticated units(essential cells) acquire multivariate transitory information.Frequent Behavior Patterns(FBPs) can be identified with a estimation of timeframe using our proposed scalable algorithms that employ collected widespread multivariate data(fleeting granularity).The research outcome,supported by rigorous analyses on two validated datasets,mark a significant progression.In the final stages of the study,a stacked Long Short-Term Memory(LSTM) model was utilized to replicate and forecast repetitive sedentary behavior patterns,leveraging data from the preceding six-hour window blocks of sedentary activity.The model effectively replicated state traits,previous action sequences,and duration,attaining an impressive 99% accuracy level as assessed through RMSE,MSE,MAPE,and r-correlation metrics.
基金funded by the National Scientific and Technological Basic Resources Investigation Program"Research and application of nutrition and health system for children aged 0–18 years in China"[2017FY101100]。
文摘Objective This study was aimed at examining the trends and correlates of physical activity(PA)and sedentary behaviors among Chinese children.Methods A total of 4,341 subjects(6,936 observations)aged 6–17 years who participated in the China Health and Nutrition Survey(2004–2015)were included.Of the subjects,41%participated in the survey twice or more.Random-effects ordinal regression models and repeated-measures mixed-effects models were used to examine the PA trends.Quantile regression models were applied to examine the factors influencing PA and sedentary behaviors.Results From 2004 to 2015,the prevalence of physical inactivity among Chinese children aged 6–17 years increased by 5.5%[odds ratio(OR),1.51;95%confidence interval(CI),1.19–1.90;P<0.001].The PA volume declined by 5.8 metabolic equivalent of task-hr/week(P<0.001),and the time spent in sedentary behaviors increased by 1.8 hr/week(P<0.001).Age,ethnicity,and region showed significant effects on the PA volume across the quartiles(P<0.001).Across the quartiles,sedentary time was significantly higher in the children residing in urban areas(P<0.001)or areas with high urbanization levels(P≤0.005)than in their counterparts.Conclusions A declining PA trend among Chinese children aged 6–17 years was observed from 2004 to2015,and certain subgroups and geographical areas are at higher risk of physical inactivity.
文摘Diabetes is a leading chronic disease of childhood and adolescence. In addition to the well-known auto-immune, insulin-dependent diabetes mellitus （type 1 diabetes （T 1D））, the past two decades have witnessed the emergence of type 2 diabetes （T2D） in children and adolescents, which previously was only seen in middle-aged or older adults. One of the key components of diabetes management is physical activity （PA）. The beneficial effects of increased PA and decreased sedentary behavior are extremely important in youth with diabetes because of the markedly increased long-term risk of cardiovascular disease in this population compared to persons without diabetes. This review aims to comprehensively summarize the epidemiologic, observational research published and listed in PubMed between 1970 and 2012 on PA and sedentary behaviors, as well as physical fitness in children and adolescents with T1D and T2D. Additionally, we describe briefly the state of knowledge on perceived barriers of PA in persons with diabetes, with a focus on hypoglycemia. Finally, we provide an overview of the epidemiological literature pertaining to health benefits of increased PA in youth with TID and T2D and briefly discuss the topic of exercise-related hypoglycemia, Copyright ~ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.
基金supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-2-003,2017-I2M-1-004)National Key R&D Program of China(2017YFC0211700,2018YFE0115300)the National Natural Science Foundation of China(91643208).
文摘Background:Inconsistent results have been reported in developed countries for relationships between sedentary behavior and cancer incidence and mortality,and evidence from the Chinese population is scarce.This study aimed to investigate such relationships in large Chinese population-based prospective cohorts and to explore the joint effect and interaction of sedentary behavior and moderate-to-vigorous physical activity(MVPA)on these relationships.Methods:We included 95,319 Chinese adults without cancer from 3 large cohorts and assessed their sedentary behavior and physical activity with a unified questionnaire.Cancer incidence and mortality were confirmed by interviewing participants or their proxies and checking hospital records and death certificates.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)for cancer and mortality were estimated using Cox proportional hazards regression models.Results:During 559,002 person-years of follow-up,2388 cancer events,1571 cancer deaths,and 4562 all-cause deaths were recorded.Sedentary behavior was associated with increased risk of developing cancer and deaths in a doseresponse manner.The multivariable-adjusted HRs(95%CIs)were the following:HR=1.16,95%CI:1.01-1.33;HR=1.24,95%CI:1.04-1.48;and HR=1.15,95%CI:1.04-1.28 for cancer incidence,cancer mortality,and all-cause mortality,respectively,for those having≥10 h/day of sedentary time compared with those having<6 h/day of sedentary time.Sedentary populations(≥10 h/day)developed cancer or died 4.09 years and 2.79 years earlier,respectively,at the index age of 50 years.Failure to achieve the recommended level of MVPA may further aggravate the adverse associations,with the highest cancer and mortality risks being observed among participants with both≥10 h/day of sedentary time and<150 min/week of MVPA.Limitations of this study include the fact that physical activity information was obtained via questionnaire instead of objective measurement and that there were insufficient incident cases for the analysis of associations between sedentary behavior and site-specific cancers.Conclusion:Sedentary behavior was associated with an increased risk of cancer and all-cause mortality among Chinese adults,especially for those with≥10 h/day of sedentary time.It is necessary to reduce sedentary time,in addition to increasing MVPA levels,for the prevention of cancer and premature death.
基金supported by Shanghai Municipal Human Resources and Social Security Bureau(2020074)Clinical Research Plan of SHDC(SHDC2020CR4006)+2 种基金Shanghai Ninth People’s Hospital(YBKA201909)Innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20212501)Shanghai Municipal Health Commission(2022XD017)。
文摘Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing dementia.We examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and mortality.We further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical activities.Methods:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to evaluation.Apolipoprotein E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this study.Results:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were recorded.In comparison to participants with leisure-time SB<5 h/day,the hazard ratio((HR),95%confidence interval(95%CI))of dementia incidence was 1.07(1.02-1.13)for 5-8 h/day and 1.25(1.13-1.38)for>8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects<60 years than in those>60 years(HR=1.26,95%CI:1.00-1.58 vs.HR=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk and 9%decreased mortality from dementia,with exercise(e.g.,swimming,cycling,aerobics,bowling)showing the strongest benefit(HR=0.82,95%CI:0.78-0.86 and HR=0.79,95%CI:0.72-0.86).Compared with APOEε4 noncarriers,APOEε4 carriers are more likely to see a decrease in Alzheimer’s disease incidence and mortality when PA is substituted for SB.Conclusion:Leisure-time SB was positively associated with the risk of dementia incidence and mortality.Replacing sedentary time with equal time spent doing PA may be associated with a significant reduction in dementia incidence and mortality risk.
文摘Regular physical activity benefits the health of the general population, more in those with sedentary behaviors. PURPOSE： To verify the impact of adding leisure-time activities to the existed sedentary behaviors. METHODS： A cross-sectional and a longitudinal analysis were undertaken in an ongoing epidemiological study （＂Move for Health＂） conducted by this Institution. The longitudinal study comprised 1572 subjects older than 35 yrs （53.8 ± 11.1 yrs, 76% women） enrolled during the period of 2004 to 2015. After a baseline assessment, the participants were submitted to a 10-week program of supervised physical exercises training and dietary counseling. The physical exercise protocol was composed by daily sessions （100 min）, 3-5x/wk, including warm up/stretching （20min）, 30 rain walking （60%-80% VO2max）, 40min strength in academy （3x 8-12 rep, 60%-70% 1RM） and stretching and cool down （10 min）. By using the International Physical Activity Questionnaire （IPAQ-way long-version 8）, it was evaluated the time spent on sedentary activities during the week and on weekends （h/day）, in the domains of sedentary transport （h/week） and physical leisure activities （h/week） at baseline （M0） and after 10 weeks （MI） of physical intervention. The Student＇s t test was used to compare moments with a significance level of 5%. RESULTS： I was shown that 18.3% presented lower values than 150 min/wk of physical activity. Lower quartile of leisure domain on weekdays along with more sedentary behavior on weekends were determined by socioeconomic characteristics such as lower income and schooling. The sample referred low income （71% earning less than 5 minimum salary wage）, low schooling （52.6% uncompleted elementary school） but in a good-excellent status of health, according their self-perception. Leisure time-physical activity increased 2.12 （P 〈 0.001）. Behaviors of sedentary transport and sitting time either weekdays or weekends did not change significantly （P 〉 0.05）. CONCLUSION： An inexpensive and institutional-conducted lifestyle modification program like the ＂Move for Health＂ can provide extra energy expenditure, as leisure time, to a low socioeconomic community. However, it has been unsuccessfully proved to change other existing sedentary behavior.
基金Supported by the Fundamental Research Funds for the China Institute of Sport Science(Grant No.23-01).
文摘Summary What is already known on this topic?Physical activity(PA)and sedentary behavior(SB)are crucial determinants of both physical and mental health outcomes.However,large-scale studies using objective measurements of these behaviors have not been widely implemented across China.
基金supported by grants from the Science and Technology Innovation 2030 Major Projects(No.2022ZD0211600)National Key R&D Program of China(No.2021YFC2502200)+5 种基金the National Natural Science Foundation of China(Nos.82071201,81971032)Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)Research Start-up Fund of Huashan Hospital(No.2022QD002)Excellence 2025 Talent Cultivation Program at Fudan University(No.3030277001)supported by grants from the National Natural Sciences Foundation of China(No.82071997)the Shanghai Rising-Star Program(No.21QA1408700).
文摘Background:Physical activity,sedentary behavior(SB),and sleep duration are associated with brain health.Effects of those on developing Parkinson’s disease(PD)are poorly investigated.This study aimed to examine the independent and joint associations of physical activity,SB,sleep with PD risk.Methods:We analyzed data on 401,697 participants from the UK Biobank cohort,which was enrolled in 2006–2010.Physical activities were measured based on a questionnaire.Sleep and SB time were defined through self-reported total number of hours.Models fitted with restricted cubic spline were conducted to test for linear and non-linear shapes of each association.Cox proportional hazards regression models were used to estimate the association of three modifiable behaviors.Results:Our analytic sample included 401,697 participants with 3030 identified cases of PD(mean age,63 years;62.9%male).PD risk was 18%lower in the high total physical activity group(95%CI,0.75–0.90),22%lower in the high leisure-time physical activity(LTPA)group(95%CI,0.71–0.86)compared with the low level and 14%higher in the high sleep duration group(95%CI,1.05–1.24)compared to moderate group.Total SB time was irrelevant with PD risk,while high TV viewing showed a 12%increase of PD risk compared to the low group(95%CI,1.02–1.22).Low computer use(0 h/day)was associated with a 14%higher risk compared to 1 h/day use(95%CI,1.04–1.26).Those associations were independent.A combination of 7 h/day sleep,moderate-to-high computer use,and moderate-to-vigorous intensity of LTPA showed lowest PD risk(HR,0.70;95%CI,0.57–0.85).Conclusions:Physical activity,SB,and sleep were associated with PD risks separately.Our findings emphasize the possibility for changing these three daily activities concurrently to lower the risk of PD.These findings may promote an active lifestyle for PD prevention.
基金Supported by the National Natural Science Foundation of China(No.82103848)the Ministry of Finance of the People’s Republic of China(No.102393220020070000016).
文摘Summary What is already known about this topic?The prevalence of insufficient physical activity(PA)among Chinese adults has shown an upward trend,reaching 22.3%in 2018.Leisure time PA(LTPA)constitutes a minimal proportion of total physical activity patterns.
基金supported by the National Natural Science Foundation of China(Grant No.32100880)Guangzhou Research-oriented Hospital。
文摘Background Physical activity(PA)is considered beneficial for lowering cardiovascular risks following type 2 diabetes mellitus(T2DM)and prediabetes,but existing evidence relies mainly on self-reported measurements.We aimed to describe the intensity-specific dose-response associations of PA and sedentary behavior(SB)with macrovascular and microvascular events among individuals with T2DM and prediabetes.Methods This study included 11,474 individuals with T2DM and prediabetes from the UK Biobank.PA,including total PA,moderate-to-vigorous intensity PA(MVPA),light-intensity PA(LPA),and SB,were measured by accelerometers over 7 days.MVPA was categorized according to the American Diabetes Association guideline-recommended level(at least 150 min/week),and total PA,LPA,and SB were grouped by tertiles.The outcomes were incidences of macrovascular events,microvascular events,heart failure(HF),and their combination(composite events).The events were ascertained using the International Classification of Diseases-10(ICD-10)codes on the hospital or death records.Results During a median follow-up of 6.8 years,1680 cases were documented,including 969 macrovascular events,839 microvascular events,and 284 incidents of HF.Accelerometer-measured PA,irrespective of intensity,was inversely associated with the risk of composite events and each outcome in the dose-response patterns.Regarding categorized PA,engagement in total PA(high vs.low)was associated with decreased risk of macrovascular events(hazard ratio(HR)=0.80;95%confidence interval(95%CI):0.67-0.95),microvascular events(HR=0.76;95%CI:0.63-0.93),and HF(HR=0.46;95%CI:0.32-0.66).Adherence to MVPA,but not LPA,above the guideline-recommended level(at least 150 min/week)was associated with reduced risk of macrovascular events(HR=0.80;95%CI:0.68-0.95),microvascular events(HR=0.76;95%CI:0.63-0.92),and HF(HR=0.65;95%CI:0.46-0.92).The minimum dose of MVPA for lowering the risk of composite events was approximately 59.0 min/week.More time spent in SB was associated with an increased risk of composite events(high vs.low,HR=1.17;95%CI:1.02-1.35)and HF(high vs.low,HR=1.54;95%CI:1.09-2.20).Replacement of 30 min of SB(HR=0.73;95%CI:0.65-0.81)and LPA(HR=0.74;95%CI:0.66-0.83)with MVPA dramatically reduced the risk of composite events.Conclusion Adherence to a higher amount of accelerometer-measured PA,especially MVPA at least 59 min/week,is associated with reduced risks of macrovascular and microvascular events among individuals with T2DM and prediabetes.Replacement of SB and LPA with MVPA helped lower the risk of diabetic vascular events.
文摘Vasovagal syncope(VVS),which is triggered by physical exertion,is typically observed in athletes or patients with structural heart disease.There have been few reported cases among sedentary individuals.This case report details the experience of a 42-year-old sedentary woman who fainted during a treadmill stress test.Despite the absence of abnormalities in baseline cardiac and neurological evaluations,the patient exhibited sinus arrest(lasting 5–12 seconds)with significant ST-segment depression during haemodynamic collapse.Comprehensive assessments,incorporating coronary angiography,echocardiography,cranial computed tomography(CT),and biochemical testing,excluded the presence of structural or ischemic heart disease,arrhythmogenic syndromes,and cerebrovascular disorders.A Calgary Syncope Symptom Score of 3 confirmed the diagnosis of VVS,a diagnosis that was further substantiated by the patient’s symptoms resolving spontaneously when she was positioned supine.This case demonstrates that exercise-induced syncope can occur in individuals who are physically unfit and have no cardiac abnormalities.Transient ST-segment changes in such cases reflect autonomic nervous system dysfunction rather than myocardial ischaemia.It is incumbent upon clinicians to consider a neurocardiogenic mechanism in sedentary patients presenting with exertional syncope despite a negative standard cardiac evaluation.
基金supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2019-I2M-2-003, 2017-I2M-1-004)National Key R&D Program of China (2017YFC0211700 and 2018YFE0115300)the National Natural Science Foundation of China (91643208)。
文摘Although emerging studies from high-income countries investigated the relationship between sedentary behavior(SB) and cardiovascular risk,little evidence came from developing countries.Moreover,the benefits of reallocating time from SB to physical activity(PA) on incident cardiovascular disease(CVD) are unknown.Using three cohorts from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project,we included 93 110 adults who were free from CVD at baseline.Cox proportional hazards models were used to calculate the hazard ratios(HRs) and 95% confidence intervals(CIs) for CVD,including stroke,coronary heart disease,and CVD death.Isotemporal substitution models were applied to estimate the per-hour effects of replacing SB with PA.After 5.8 years follow-up,3799 CVD cases were identified.A gradient positive association between sedentary time and incident CVD was observed.Relative to those with <5 h/d sedentary time,the multivariable-adjusted HRs(95% CIs) of CVD incidence were 1.07(0.96-1.20),1.27(1.13-1.43) and 1.51(1.34-1.70) for those having 5-<8,8-<10,and> 10 h/d sedentary time,respectively.When participants were cross-classified by SB and moderate to vigorous physical activity(MVPA) level,the CVD risk was highest in those with> 10 h/d SB and <150 min/week MVPA.Among those who reported> 5 h/d sedentary time,per-hour substitution of SB with light,moderate,and vigorous PA reduced incident CVD risk by 5%,6%,and 8%,respectively.The study first found that sedentary time was associated with increased incident CVD risk among Chinese adults and that substitution of SB with PA of any intensity could convey cardiovascular benefits among those with> 5 h/d SB.
基金This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil(CAPES)-Finance Code 001.
文摘The aim of the present study was to investigate the relationship of dynapenia combined with sedentary behavior(SB)on the risk of mortality in older adults living in a Brazilian community.A total of 322 participants aged60 years from the ELSIA(Longitudinal Study of Elderly Health in Alcobaça)prospective cohort were included.Dynapenia was diagnosed when the handgrip strength was<27 kg for men and<16 kg for women.The exposure time to SB was assessed considering the total time spent sitting during one day in the week and one day on the weekend.When combined with dynapenia,we derived the construction of four groups:best behavior(absence of dynapenia and low SB),intermediate behavior(absence of dynapenia and high SB;presence of dynapenia and low SB)and worst behavior(presence of dynapenia and high SB).Mortality was assessed by the follow-up time until death and/or censorship.During the 5-year follow-up of the study,55 participants progressed to death.In the adjusted models,the dynapenia and the time spent exposed to SB were analyzed in a combined way,the older adults with worse behavior(high SB and dynapenia)had higher risk ratios for mortality(hazard ratio 2.46;95%confidence interval 1.01–5.97)than the best behavior group.Older adults with dynapenia are at greater risk for all-cause mortality,which is aggravated by the addition of longer exposure to SB.
基金the National Natural Science Foundation of China(No.81760049)the Jiangxi Science and Technology Innovation Platform Project(No.20165BCD41005)+2 种基金the National Key R&D Program of China(No.2018YFC1312902)the Science and Technology Plan of Health Commission of Jiangxi Province(No.20185215)the Key Project of Education Department of Jiangxi Province(No.GJJ170013).
文摘Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese population.We aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern China.Methods:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 years.Baseline self-reported PA and SB were collected via the questionnaire.Kaplan–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause mortality.Results:A total of 11,744 eligible participants were included in the analysis.Over an average of 5.4 years of follow-up,796 deaths occurred.The risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause mortality.Participants with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.
基金supported by Youth Fund of Humanities and Social Sciences Research Project of Education Ministry(22YJC890025).
文摘Objective:This study was conducted to explore the relationships among sedentary behavior(SB),electronic product addiction(EPA),and depression(D)in adolescents during the COVID-19 epidemic.Methods:A total of 604 adolescents(including 309 girls and 295 boys aged 12-18)were selected from Qufu City,Shandong Province,China for three rounds of investigation.The model was constructed using AMOS 23.0 software,and cross-lagged analysis was conducted.Results:SB at T1 can significantly positively predict SB and EPA at T2(p<0.05).EPA at T1 can significantly positively predict SB and D at T2(p<0.05).Physical activity level and SB at T2 can significantly predict SB and EPA at T3(p<0.05).EPA at T2 can significantly predict SB,EPA,and D at T3(p<0.05).Conclusions:SB and EPA are predictive factors for D.Moreover,SB can significantly positively predict D and indirectly predict D through the mediating effect of EPA.
基金financed by the grants from the Zhejiang Province Higher Education Research Fund Program(NO.JG20220766)National Natural Science Foundation of China(No.71774147)Innovation and Entrepreneurship Training Program for College Students in Zhejiang Province(No.S202010344012)。
文摘Thousands of years ago,the concept of Jiu Zuo Shang Rou(久坐伤肉long-time sitting damages muscles)was introduced in traditional Chinese medicine(TCM).It was clearly recorded in ancient books,that prolonged sitting disrupts the circulation of qi and blood,damages muscles,impairs spleen function,and ultimately leads to diseases.Modern biomedical evidence shows that sedentary behavior,including prolonged sitting,affects endocrine,metabolic,and physiological functions,increasing the risk of chronic diseases.This article systematically reviews TCM records of the health impacts of long-time sitting and biomedical findings,to explore the pathophysiological mechanisms underlying the health risks of prolonged sitting.By integrating TCM's preventative philosophy,namely Zhi Wei Bing(治未病preventing a disease before it arises),with modern preventive medicine,this study offers insights into strategies for mitigating the health risks associated with sedentary behavior.
文摘Background:Grounded in intersectionality theory,this study examined the 6-year prevalence trend and correlates in meeting Canada’s 24-Hour Movement Guidelines(Guidelines hereafter)in a nationally representative adolescent samples of South Korea(officially the Republic of Korea).Methods:Self-reported,annually repeated cross-sectional data collected between 2013 and 2018 were used(n=372,433,12-17 years old,47.9%females).Adolescents were categorized as meeting or not meeting different sets of physical activity,screen time(ST),and sleep recommendations within the Guidelines,separately for weekdays and weekend days.Intersectional correlates included sex and social class(i.e.,family economic status,parental education level,and academic performance).Multiple logistic regression analyses were performed.Results:Overall,the proportion of adolescents meeting physical activity,ST,and sleep recommendations were 5.3%,60.3%,and 10.2%on weekdays and 5.3%,28.2%,and 46.4%on weekend days,respectively.Between 2013 and 2018,no substantial changes were observed for meeting the physical activity or sleep recommendation,while meeting the ST recommendation was markedly lower in 2018.The proportion of meeting all 3 recommendations were 0.5%for weekdays and 0.8%for weekend days.Overall,compared to female adolescents,male adolescents were consistently associated with more favorable patterns of meeting different sets of recommendations,regardless of social class.Among females only,social class appeared to be not important or even detrimental in meeting different sets of recommendations.Being male,compounded with social class,was associated with meeting the ST recommendation.Conclusion:Less than 1%of Korean adolescents met the overall Guidelines.Intersectionality-based analysis and intervention may be important in promoting healthy active lifestyles among South Korean adolescents.
