Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can...The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.展开更多
Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimati...Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimating settling-time function (STF) of the hybrid systems.When switching dynamics are FTS and impulsive dynamics involve destabilizing delay-dependent impulses, the FTS is retained if the impulses occur infrequently.展开更多
Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectiv...Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.展开更多
Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems...Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems are among these application domains.Data Distribution Service(DDS)is a communication mechanism based on Data-Centric Publish-Subscribe(DCPS)model.It is used for distributed systems with real-time operational constraints.Java Message Service(JMS)is a messaging standard for enterprise systems using Service Oriented Architecture(SOA)for non-real-time operations.JMS allows Java programs to exchange messages in a loosely coupled fashion.JMS also supports sending and receiving messages using a messaging queue and a publish-subscribe interface.In this article,we propose an architecture enabling the automated integration of distributed real-time and non-real-time systems.We test our proposed architecture using a distributed Command,Control,Communications,Computers,and Intelligence(C4I)system.The system has DDS-based real-time Combat Management System components deployed to naval warships,and SOA-based non-real-time Command and Control components used at headquarters.The proposed solution enables the exchange of data between these two systems efficiently.We compare the proposed solution with a similar study.Our solution is superior in terms of automation support,ease of implementation,scalability,and performance.展开更多
The intricate interplay between neurotransmitter systems,neural circuits,and neuroendocrine pathways underpins brain function and dysfunction in neurological and psychiatric disorders.This review synthesizes contempor...The intricate interplay between neurotransmitter systems,neural circuits,and neuroendocrine pathways underpins brain function and dysfunction in neurological and psychiatric disorders.This review synthesizes contemporary advances in neuropharmacology,focusing on dopaminergic,serotonergic,glutamatergic,and GABAergic systems,and their roles in regulating motor control,cognition,emotion,and stress responses.Dopaminergic pathways,including the nigrostriatal,mesolimbic,and mesocortical circuits,are explored in the context of Parkinson’s disease,schizophrenia,and addiction,with emphasis on pharmacological agents such as L-DOPA,antipsychotics,and amphetamines.Serotonergic modulation through SSRIs and psychedelics is examined for its impact on mood and neuroplasticity,while glutamatergic and GABAergic systems are discussed in relation to synaptic plasticity,excitotoxicity,and therapeutic innovations like ketamine and benzodiazepines.The neuroendocrine system,particularly the hypothalamic-pituitary-adrenal(HPA)axis,is highlighted for its role in stress-related disorders and interactions with neurotransmitter networks.Despite progress,significant challenges persist,including translational gaps between preclinical models and human trials,species-specifi c receptor disparities,and ethical dilemmas surrounding cognitive enhancers and genetic manipulation.Emerging frontiers such as nanotechnology-enabled drug delivery,optogenetics,and gut-brain axis modulation are reviewed as transformative approaches to overcome these barriers.Personalized medicine,integrating neuroimaging biomarkers and pharmacogenomics,promises to tailor therapies to individual neural and genetic profi les,while biased agonists and closed-loop systems exemplify the shift toward circuit-specifi c interventions.Ethical considerations,including equitable access to advanced therapies and responsible innovation,are underscored as critical to ensuring societal benefi t.By harmonizing molecular precision with systems neuroscience,this review advocates for interdisciplinary strategies to advance neuropharmacology,ultimately aiming to restore dynamic neural and neuroendocrine homeostasis in health and disease.展开更多
A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,...A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,social network)in the corresponding social-environmental systems(SES).To address these challenges,we need to understand decisions made and actions taken by agents,the outcomes of their actions,including the feedbacks on the corresponding agents and environment.The science of complex adaptive systems-complex adaptive sys tems(CAS)science-has a significant potential to handle such challenges.We address the advantages of CAS science for sustainability by identifying the key elements and challenges in sustainability science,the generic features of CAS,and the key advances and challenges in modeling CAS.Artificial intelligence and data science combined with agent-based modeling promise to improve understanding of agents’behaviors,detect SES struc tures,and formulate SES mechanisms.展开更多
1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established...1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established in the mid-20th century,blunt body theories led to the creation of ablative heat shields that effectively manage thermal loads through thermo-chemo-mechanical decomposition.This paper revisits the development and application of ablative TPS materials,which are single-mission solutions capable of withstanding entry velocities surpassing 10 km/s.展开更多
Electric Vehicle Charging Systems(EVCS)are increasingly vulnerable to cybersecurity threats as they integrate deeply into smart grids and Internet ofThings(IoT)environments,raising significant security challenges.Most...Electric Vehicle Charging Systems(EVCS)are increasingly vulnerable to cybersecurity threats as they integrate deeply into smart grids and Internet ofThings(IoT)environments,raising significant security challenges.Most existing research primarily emphasizes network-level anomaly detection,leaving critical vulnerabilities at the host level underexplored.This study introduces a novel forensic analysis framework leveraging host-level data,including system logs,kernel events,and Hardware Performance Counters(HPC),to detect and analyze sophisticated cyberattacks such as cryptojacking,Denial-of-Service(DoS),and reconnaissance activities targeting EVCS.Using comprehensive forensic analysis and machine learning models,the proposed framework significantly outperforms existing methods,achieving an accuracy of 98.81%.The findings offer insights into distinct behavioral signatures associated with specific cyber threats,enabling improved cybersecurity strategies and actionable recommendations for robust EVCS infrastructure protection.展开更多
Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present so...Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.展开更多
Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportatio...Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportation systems (ITS) and Advanced Driver Assistance Systems (ADAS), the development of efficient and reliable traffic light detection mechanisms is crucial for enhancing road safety and traffic management. This paper presents an optimized convolutional neural network (CNN) framework designed to detect traffic lights in real-time within complex urban environments. Leveraging multi-scale pyramid feature maps, the proposed model addresses key challenges such as the detection of small, occluded, and low-resolution traffic lights amidst complex backgrounds. The integration of dilated convolutions, Region of Interest (ROI) alignment, and Soft Non-Maximum Suppression (Soft-NMS) further improves detection accuracy and reduces false positives. By optimizing computational efficiency and parameter complexity, the framework is designed to operate seamlessly on embedded systems, ensuring robust performance in real-world applications. Extensive experiments using real-world datasets demonstrate that our model significantly outperforms existing methods, providing a scalable solution for ITS and ADAS applications. This research contributes to the advancement of Artificial Intelligence-driven (AI-driven) pattern recognition in transportation systems and offers a mathematical approach to improving efficiency and safety in logistics and transportation networks.展开更多
This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates senso...This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates sensor and actuator disturbances within the dynamics of follower robots.Each follower robot has unknown dynamics and control inputs,which expose it to the risks of both sensor and actuator attacks.The leader robot,described by a secondorder,time-varying nonlinear model,transmits its position,velocity,and acceleration information to follower robots through a wireless connection.To handle the complex setup and communication among robots in the network,we design a robust hybrid distributed adaptive control strategy combining the effect of sensor and actuator attack,which ensures asymptotic consensus,extending beyond conventional bounded consensus results.The proposed framework employs fuzzy logic systems(FLSs)as proactive controllers to estimate unknown nonlinear behaviors,while also effectively managing sensor and actuator attacks,ensuring stable consensus among all agents.To counter the impact of the combined signal attack on follower dynamics,a specialized robust control mechanism is designed,sustaining system stability and performance under adversarial conditions.The efficiency of this control strategy is demonstrated through simulations conducted across two different directed communication topologies,underscoring the protocol’s adaptability,resilience,and effectiveness in maintaining global consensus under complex attack scenarios.展开更多
Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses si...Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses significant challenges and requires an integrated approach.In this study,a unified requirement modeling approach is proposed based on unified architecture framework(UAF).Theoretical models are proposed which compose formalized descriptions from both topdown and bottom-up perspectives.Based on the description,the UAF profile is proposed to represent the SoS mission and constituent systems(CS)goal.Moreover,the agent-based simulation information is also described based on the overview,design concepts,and details(ODD)protocol as the complement part of the SoS profile,which can be transformed into different simulation platforms based on the eXtensible markup language(XML)technology and model-to-text method.In this way,the design of the SoS is simulated automatically in the early design stage.Finally,the method is implemented and an example is given to illustrate the whole process.展开更多
Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the...Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.展开更多
There has been an increasing interest in integrating decision support systems (DSS) and expert systems (ES) to provide decision makers a more accessible, productive and domain-independent information and computing env...There has been an increasing interest in integrating decision support systems (DSS) and expert systems (ES) to provide decision makers a more accessible, productive and domain-independent information and computing environment. This paper is aimed at designing a multiple expert systems integrated decision support system (MESIDSS) to enhance decision makers' ability in more complex cases. The basic framework, management system of multiple ESs, and functions of MESIDSS are presented. The applications of MESIDSS in large-scale decision making processes are discussed from the following aspects of problem decomposing, dynamic combination of multiple ESs, link of multiple bases and decision coordinating. Finally, a summary and some ideas for the future are presented.展开更多
Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population. It is the primary known cause of gast...Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金Hongguang Wu,Both authors contributed equally to this work and share first authorshipLing Dong,Both authors contributed equally to this work and share first authorship。
文摘The human retina,a complex and highly specialized structure,includes multiple cell types that work synergistically to generate and transmit visual signals.However,genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness.Treatment options for retinal diseases are limited,and there is an urgent need for innovative therapeutic strategies.Cell and gene therapies are promising because of the efficacy of delivery systems that transport therapeutic genes to targeted retinal cells.Gene delivery systems hold great promise for treating retinal diseases by enabling the targeted delivery of therapeutic genes to affected cells or by converting endogenous cells into functional ones to facilitate nerve regeneration,potentially restoring vision.This review focuses on two principal categories of gene delivery vectors used in the treatment of retinal diseases:viral and non-viral systems.Viral vectors,including lentiviruses and adeno-associated viruses,exploit the innate ability of viruses to infiltrate cells,which is followed by the introduction of therapeutic genetic material into target cells for gene correction.Lentiviruses can accommodate exogenous genes up to 8 kb in length,but their mechanism of integration into the host genome presents insertion mutation risks.Conversely,adeno-associated viruses are safer,as they exist as episomes in the nucleus,yet their limited packaging capacity constrains their application to a narrower spectrum of diseases,which necessitates the exploration of alternative delivery methods.In parallel,progress has also occurred in the development of novel non-viral delivery systems,particularly those based on liposomal technology.Manipulation of the ratios of hydrophilic and hydrophobic molecules within liposomes and the development of new lipid formulations have led to the creation of advanced non-viral vectors.These innovative systems include solid lipid nanoparticles,polymer nanoparticles,dendrimers,polymeric micelles,and polymeric nanoparticles.Compared with their viral counterparts,non-viral delivery systems offer markedly enhanced loading capacities that enable the direct delivery of nucleic acids,mRNA,or protein molecules into cells.This bypasses the need for DNA transcription and processing,which significantly enhances therapeutic efficiency.Nevertheless,the immunogenic potential and accumulation toxicity associated with non-viral particulate systems necessitates continued optimization to reduce adverse effects in vivo.This review explores the various delivery systems for retinal therapies and retinal nerve regeneration,and details the characteristics,advantages,limitations,and clinical applications of each vector type.By systematically outlining these factors,our goal is to guide the selection of the optimal delivery tool for a specific retinal disease,which will enhance treatment efficacy and improve patient outcomes while paving the way for more effective and targeted therapeutic interventions.
基金supported by the National Natural Science Foundation of China(61833005)
文摘Dear Editor,This letter studies finite-time stability (FTS) of impulsive and switched hybrid systems with delay-dependent impulses. Some conditions, based on Lyapunov method, are proposed for ensuring FTS and estimating settling-time function (STF) of the hybrid systems.When switching dynamics are FTS and impulsive dynamics involve destabilizing delay-dependent impulses, the FTS is retained if the impulses occur infrequently.
基金supported in part by the National Natural Science Foundation of China(62173255,62188101)Shenzhen Key Laboratory of Control Theory and Intelligent Systems(ZDSYS20220330161800001)
文摘Dear Editor,In this letter,a constrained networked predictive control strategy is proposed for the optimal control problem of complex nonlinear highorder fully actuated(HOFA)systems with noises.The method can effectively deal with nonlinearities,constraints,and noises in the system,optimize the performance metric,and present an upper bound on the stable output of the system.
文摘Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems are among these application domains.Data Distribution Service(DDS)is a communication mechanism based on Data-Centric Publish-Subscribe(DCPS)model.It is used for distributed systems with real-time operational constraints.Java Message Service(JMS)is a messaging standard for enterprise systems using Service Oriented Architecture(SOA)for non-real-time operations.JMS allows Java programs to exchange messages in a loosely coupled fashion.JMS also supports sending and receiving messages using a messaging queue and a publish-subscribe interface.In this article,we propose an architecture enabling the automated integration of distributed real-time and non-real-time systems.We test our proposed architecture using a distributed Command,Control,Communications,Computers,and Intelligence(C4I)system.The system has DDS-based real-time Combat Management System components deployed to naval warships,and SOA-based non-real-time Command and Control components used at headquarters.The proposed solution enables the exchange of data between these two systems efficiently.We compare the proposed solution with a similar study.Our solution is superior in terms of automation support,ease of implementation,scalability,and performance.
文摘The intricate interplay between neurotransmitter systems,neural circuits,and neuroendocrine pathways underpins brain function and dysfunction in neurological and psychiatric disorders.This review synthesizes contemporary advances in neuropharmacology,focusing on dopaminergic,serotonergic,glutamatergic,and GABAergic systems,and their roles in regulating motor control,cognition,emotion,and stress responses.Dopaminergic pathways,including the nigrostriatal,mesolimbic,and mesocortical circuits,are explored in the context of Parkinson’s disease,schizophrenia,and addiction,with emphasis on pharmacological agents such as L-DOPA,antipsychotics,and amphetamines.Serotonergic modulation through SSRIs and psychedelics is examined for its impact on mood and neuroplasticity,while glutamatergic and GABAergic systems are discussed in relation to synaptic plasticity,excitotoxicity,and therapeutic innovations like ketamine and benzodiazepines.The neuroendocrine system,particularly the hypothalamic-pituitary-adrenal(HPA)axis,is highlighted for its role in stress-related disorders and interactions with neurotransmitter networks.Despite progress,significant challenges persist,including translational gaps between preclinical models and human trials,species-specifi c receptor disparities,and ethical dilemmas surrounding cognitive enhancers and genetic manipulation.Emerging frontiers such as nanotechnology-enabled drug delivery,optogenetics,and gut-brain axis modulation are reviewed as transformative approaches to overcome these barriers.Personalized medicine,integrating neuroimaging biomarkers and pharmacogenomics,promises to tailor therapies to individual neural and genetic profi les,while biased agonists and closed-loop systems exemplify the shift toward circuit-specifi c interventions.Ethical considerations,including equitable access to advanced therapies and responsible innovation,are underscored as critical to ensuring societal benefi t.By harmonizing molecular precision with systems neuroscience,this review advocates for interdisciplinary strategies to advance neuropharmacology,ultimately aiming to restore dynamic neural and neuroendocrine homeostasis in health and disease.
基金The National Science Foundation funded this research under the Dy-namics of Coupled Natural and Human Systems program(Grants No.DEB-1212183 and BCS-1826839)support from San Diego State University and Auburn University.
文摘A significant number and range of challenges besetting sustainability can be traced to the actions and inter actions of multiple autonomous agents(people mostly)and the entities they create(e.g.,institutions,policies,social network)in the corresponding social-environmental systems(SES).To address these challenges,we need to understand decisions made and actions taken by agents,the outcomes of their actions,including the feedbacks on the corresponding agents and environment.The science of complex adaptive systems-complex adaptive sys tems(CAS)science-has a significant potential to handle such challenges.We address the advantages of CAS science for sustainability by identifying the key elements and challenges in sustainability science,the generic features of CAS,and the key advances and challenges in modeling CAS.Artificial intelligence and data science combined with agent-based modeling promise to improve understanding of agents’behaviors,detect SES struc tures,and formulate SES mechanisms.
文摘1.Introduction to ablative TPS The Mars 2020 mission underscored the critical role of ablative Thermal Protection Systems(TPS)during atmospheric entry,where spacecraft encounter extreme aerodynamic heating.Established in the mid-20th century,blunt body theories led to the creation of ablative heat shields that effectively manage thermal loads through thermo-chemo-mechanical decomposition.This paper revisits the development and application of ablative TPS materials,which are single-mission solutions capable of withstanding entry velocities surpassing 10 km/s.
文摘Electric Vehicle Charging Systems(EVCS)are increasingly vulnerable to cybersecurity threats as they integrate deeply into smart grids and Internet ofThings(IoT)environments,raising significant security challenges.Most existing research primarily emphasizes network-level anomaly detection,leaving critical vulnerabilities at the host level underexplored.This study introduces a novel forensic analysis framework leveraging host-level data,including system logs,kernel events,and Hardware Performance Counters(HPC),to detect and analyze sophisticated cyberattacks such as cryptojacking,Denial-of-Service(DoS),and reconnaissance activities targeting EVCS.Using comprehensive forensic analysis and machine learning models,the proposed framework significantly outperforms existing methods,achieving an accuracy of 98.81%.The findings offer insights into distinct behavioral signatures associated with specific cyber threats,enabling improved cybersecurity strategies and actionable recommendations for robust EVCS infrastructure protection.
基金supported in part by the National Natural Science Foundation of China(62273255,62350003,62088101)the Shanghai Science and Technology Cooperation Project(22510712000,21550760900)+1 种基金the Shanghai Municipal Science and Technology Major Project(2021SHZDZX0100)the Fundamental Research Funds for the Central Universities
文摘Dear Editor,This letter is concerned with the problem of time-varying formation tracking for heterogeneous multi-agent systems(MASs) under directed switching networks. For this purpose, our first step is to present some sufficient conditions for the exponential stability of a particular category of switched systems.
基金funded by the Deanship of Scientific Research at Northern Border University,Arar,Saudi Arabia through research group No.(RG-NBU-2022-1234).
文摘Transportation systems are experiencing a significant transformation due to the integration of advanced technologies, including artificial intelligence and machine learning. In the context of intelligent transportation systems (ITS) and Advanced Driver Assistance Systems (ADAS), the development of efficient and reliable traffic light detection mechanisms is crucial for enhancing road safety and traffic management. This paper presents an optimized convolutional neural network (CNN) framework designed to detect traffic lights in real-time within complex urban environments. Leveraging multi-scale pyramid feature maps, the proposed model addresses key challenges such as the detection of small, occluded, and low-resolution traffic lights amidst complex backgrounds. The integration of dilated convolutions, Region of Interest (ROI) alignment, and Soft Non-Maximum Suppression (Soft-NMS) further improves detection accuracy and reduces false positives. By optimizing computational efficiency and parameter complexity, the framework is designed to operate seamlessly on embedded systems, ensuring robust performance in real-world applications. Extensive experiments using real-world datasets demonstrate that our model significantly outperforms existing methods, providing a scalable solution for ITS and ADAS applications. This research contributes to the advancement of Artificial Intelligence-driven (AI-driven) pattern recognition in transportation systems and offers a mathematical approach to improving efficiency and safety in logistics and transportation networks.
文摘This research paper tackles the complexities of achieving global fuzzy consensus in leader-follower systems in robotic systems,focusing on robust control systems against an advanced signal attack that integrates sensor and actuator disturbances within the dynamics of follower robots.Each follower robot has unknown dynamics and control inputs,which expose it to the risks of both sensor and actuator attacks.The leader robot,described by a secondorder,time-varying nonlinear model,transmits its position,velocity,and acceleration information to follower robots through a wireless connection.To handle the complex setup and communication among robots in the network,we design a robust hybrid distributed adaptive control strategy combining the effect of sensor and actuator attack,which ensures asymptotic consensus,extending beyond conventional bounded consensus results.The proposed framework employs fuzzy logic systems(FLSs)as proactive controllers to estimate unknown nonlinear behaviors,while also effectively managing sensor and actuator attacks,ensuring stable consensus among all agents.To counter the impact of the combined signal attack on follower dynamics,a specialized robust control mechanism is designed,sustaining system stability and performance under adversarial conditions.The efficiency of this control strategy is demonstrated through simulations conducted across two different directed communication topologies,underscoring the protocol’s adaptability,resilience,and effectiveness in maintaining global consensus under complex attack scenarios.
基金Fifth Electronic Research Institute of the Ministry of Industry and Information Technology(HK07202200877)Pre-research Project on Civil Aerospace Technologies of CNSA(D020101)+2 种基金Zhejiang Provincial Science and Technology Plan Project(2022C01052)Frontier Scientific Research Program of Deep Space Exploration Laboratory(2022-QYKYJHHXYF-018,2022-QYKYJH-GCXD-001)Zhiyuan Laboratory(ZYL2024001)。
文摘Model-based system-of-systems(SOS)engineering(MBSoSE)is becoming a promising solution for the design of SoS with increasing complexity.However,bridging the models from the design phase to the simulation phase poses significant challenges and requires an integrated approach.In this study,a unified requirement modeling approach is proposed based on unified architecture framework(UAF).Theoretical models are proposed which compose formalized descriptions from both topdown and bottom-up perspectives.Based on the description,the UAF profile is proposed to represent the SoS mission and constituent systems(CS)goal.Moreover,the agent-based simulation information is also described based on the overview,design concepts,and details(ODD)protocol as the complement part of the SoS profile,which can be transformed into different simulation platforms based on the eXtensible markup language(XML)technology and model-to-text method.In this way,the design of the SoS is simulated automatically in the early design stage.Finally,the method is implemented and an example is given to illustrate the whole process.
基金supported by the Liaoning Revitalization Talents Program(XLYC2203148)
文摘Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.
文摘There has been an increasing interest in integrating decision support systems (DSS) and expert systems (ES) to provide decision makers a more accessible, productive and domain-independent information and computing environment. This paper is aimed at designing a multiple expert systems integrated decision support system (MESIDSS) to enhance decision makers' ability in more complex cases. The basic framework, management system of multiple ESs, and functions of MESIDSS are presented. The applications of MESIDSS in large-scale decision making processes are discussed from the following aspects of problem decomposing, dynamic combination of multiple ESs, link of multiple bases and decision coordinating. Finally, a summary and some ideas for the future are presented.
基金supported by the Aerospace Science and Technology Innovation Foundation of China(CAST2014CH01)the Aeronautical Science Foundation of China(2015ZC560007)+1 种基金the Jiangxi Natural Science Foundation of China(20151BBE50026)National Natural Science Foundation of China(11462015)
基金supported by National Natural Science Foundation of China(61403149,61573298)Natural Science Foundation of Fujian Province(2015J01261,2016J05165)Foundation of Huaqiao University(Z14Y0002)
文摘Helicobacter pylori (H. pylori) is one of the most common pathogenic bacterial infections and is found in the stomachs of approximately half of the world’s population. It is the primary known cause of gastritis, gastroduodenal ulcer disease and gastric cancer. However, combined drug therapy as the general treatment in the clinic, the rise of antibiotic-resistant bacteria, adverse reactions and poor patient compliance are major obstacles to the eradication of H. pylori. Oral site-specific drug delivery systems that could increase the longevity of the treatment agent at the target site might improve the therapeutic effect and avoid side effects. Gastroretentive drug delivery systems potentially prolong the gastric retention time and controlled/sustained release of a drug, thereby increasing the concentration of the drug at the application site, potentially improving its bioavailability and reducing the necessary dosage. Recommended gastroretentive drug delivery systems for enhancing local drug delivery include floating systems, bioadhesive systems and expandable systems. In this review, we summarize the important physiological parameters of the gastrointestinal tract that affect the gastric residence time. We then focus on various aspects useful in the development of gastroretentive drug delivery systems, including current trends and the progress of novel forms, especially with respect to their application for the treatment of H. pylori infections.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
