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OBSERVATION OF SELF-PUMPED PHASE CONJUGATION WITH HIGH REFLECTIVITY AND FAST RESPONSE IN Cu-DOPED KNSBN CRYSTAL
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作者 吕新亮 岳学锋 +7 位作者 宋永远 孙大亮 姜全中 陈焕矗 许京军 武元庆 刘思敏 张光寅 《Chinese Science Bulletin》 SCIE EI CAS 1992年第24期2038-2042,共5页
Self-pumped phase conjugation (SPPC) is completely self-contained and requires no external mirrors, pumping beams or applied electric fields. Because of its simplicity and high reflectivity, SPPC has a host of poten... Self-pumped phase conjugation (SPPC) is completely self-contained and requires no external mirrors, pumping beams or applied electric fields. Because of its simplicity and high reflectivity, SPPC has a host of potential applications including correcting spatial phase distortion, and optical image processing. At the present time, SPPC has been realized in BaTiO<sub>3</sub>, KNbO<sub>3</sub>, Ce-doped SBN and KNSBN single crystals. The KNSBN 展开更多
关键词 photorefracfive effect KNSBN CRYSTAL self-pumped phase conjugation
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Crystal growth and high reflectivity self-pumped phase conjugation of (Cu, Ce)-doped (KNa)_(0.1)(Sr_(0.6)Ba_(0.4))_(0.9)Nb_2O_6 crystal
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作者 张日理 谢祥寿 +4 位作者 莫党 窦硕星 廉英武 张家森 叶佩弦 《Chinese Science Bulletin》 SCIE EI CAS 1995年第4期295-299,共5页
Potassium sodium strontium barium niobate (KNSBN) crystal is one of the important photorefractive ferroelectric crystal materials, not only having good photorefractive properties, but also many advantages over other p... Potassium sodium strontium barium niobate (KNSBN) crystal is one of the important photorefractive ferroelectric crystal materials, not only having good photorefractive properties, but also many advantages over other photorefractive crystal materials: (ⅰ) it is easy to grow in large size, (ⅱ) neither twinning nor poling problems exist; (ⅲ) it can accommodate a wide range of solution; (ⅳ) it is easy to be doped with many kinds of dopants. 展开更多
关键词 KNSBN CRYSTAL PHOTOREFRACTIVE effect self-pumped phase conjugation.
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OPTICAL PHASE CONJUGATION RESPONSE OF PHOTOINDUCED POLYMER FILMS CONTAINING AZOBENZENE MOIETIES WITH CHIRAL GROUP 被引量:1
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作者 范星河 周其凤 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2002年第2期99-104,共6页
An optically active monomer containing azobenzene moieties with chiral group (s-2-methyl-butyl), 4-[2-(methacryloyloxy)ethyloxy] -4'-(s-2-methyl-1-butyloxycarbonyl) azobenzene (M1) was synthesized. Polymer (PM1) p... An optically active monomer containing azobenzene moieties with chiral group (s-2-methyl-butyl), 4-[2-(methacryloyloxy)ethyloxy] -4'-(s-2-methyl-1-butyloxycarbonyl) azobenzene (M1) was synthesized. Polymer (PM1) possessing optical phase conjugated response was obtained by homopolymerization of the optically active monomer (M1) using free radical polymerization. The polymer was very soluble in common solvents and good optical quality films could be easily fabricated by spin coating. The optical phase conjugated responses of the polymer PM1 were measured by degenerate four-wave mixing (DFWM). In comparison with polymer containing no chiral group, it was found from the preliminary measurement of photoisomeric change that optical phase conjugated response of the PM1 in the long-range order hexagonal symmetry microstructure could be easily controlled by choosing the appropriate polarization direction of the irradiating beams (514.5 nm) and the irradiating number, presumably due to the chiral group in the PM1 molecular structure. For the case of the polymer investigated here, a chiral group side chain was introduced to increase optical phase conjugated response intensity with different polarization directions of the irradiating beams, which aims originally at searching for a new photoactive material. 展开更多
关键词 azobenzene polymer chiral groups degenerate four-wave mixing optical phase conjugation
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Wavefront correction of Ti:sapphire terawatt laser with varying precision of phase conjugation between deformable mirror and wavefront sensor 被引量:1
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作者 Yu Liang-Hong Liang Xiao-Yan +4 位作者 Ren Zhi-Jun Wang Li Xu Yi Lu Xiao-Ming Yu Guo-Hao 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第1期192-198,共7页
The phase conjugation between the deformable mirror and the wavefront sensor in the aberration correction of a terawatt Ti:sapphire laser is studied experimentally and theoretically in this paper. At varying values o... The phase conjugation between the deformable mirror and the wavefront sensor in the aberration correction of a terawatt Ti:sapphire laser is studied experimentally and theoretically in this paper. At varying values of phase- conjugation precision, we focus the corresponding beams into spots of the same size of 5.1 μm × 5.3 μm with a f/4 parabola in the 32 TW/36 fs Ti:sapphire laser system. The results show that the precision of conjugation can induce an intensity modulation but does not significantly affect the wavefront correction. 展开更多
关键词 adaptive optics wave front correction phase conjugation deformable mirror
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Theoretical study on phase conjugation in weakly injected vertical-cavity surface-emitting lasers
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作者 张伟利 潘炜 +3 位作者 罗斌 李孝峰 邹喜华 王梦遥 《Chinese Physics B》 SCIE EI CAS CSCD 2008年第5期1821-1825,共5页
This paper gives a detailed theoretical investigation on phase conjugation induced by nearly degenerate fourwave mixing in single mode vertical-cavity surface-emitting lasers (VCSELs) with weak optical injection. Co... This paper gives a detailed theoretical investigation on phase conjugation induced by nearly degenerate fourwave mixing in single mode vertical-cavity surface-emitting lasers (VCSELs) with weak optical injection. Considering VCSELs that can work in linearly polarized or elliptically polarized states, it derives the theoretical expression of the conjugated field by small signal analysis based on the vectoral rate equations-the spin-flip model. For linearly polarized state, VCSELs show similar conjugate spectra to edge-emitting semiconductor lasers. For the elliptically polarized state, dichroism and birefringence parameters as well as the spin-flip rate can change the conjugate spectra. Especially, when frequency detuning of the probe and pump waves is between the positive and negative relaxation oscillation frequency, changes are evident. For specific values of parameters, conjugate efficiency between 20 dB to 40 dB are obtained. 展开更多
关键词 phase conjugate VCSELS POLARIZATION four-wave mixing
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Orientation-enhanced nonlinear optical properties and phase-conjugate reflective system of a novel Azobenzene doped polymer film 被引量:1
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作者 谢茹胜 范文彬 +1 位作者 陆明 赵有源 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第9期2725-2730,共6页
This paper reports that the nonlinear refractive index of a novel organic optical storage film doped azodiphenylamine polymer is measured by using the Z-scan technique. The nonlinear refractive index up to 3.7× 1... This paper reports that the nonlinear refractive index of a novel organic optical storage film doped azodiphenylamine polymer is measured by using the Z-scan technique. The nonlinear refractive index up to 3.7× 10^-6 cm^2/W induced by thermo-optical effect is obtained. It indicates that the sample has excellent optical non- linear properties. The physical mechanism of the great nonlinear optical effect is analysed and the optical conjugate characteristic is also discussed with degenerate four-wave-mixing. The phase conjugate wave diffracted from the formative refractive index grating in the sample is acquired and its equivalent reflectivity reaches about 22%. On this basis, the reflective wave phase-conjugated mirror system was designed, and the image aberration experienced in propagation in the storage experiment is corrected by using the system. 展开更多
关键词 phase conjugated mirror azo-diphenylamine nonlinear refractive index orientation-enhanced Z-SCAN
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The signal synchronization transmission of a spatiotemporal chaos network constituted by a laser phase-conjugate wave 被引量:2
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作者 李文琳 李淑凤 李钢 《Chinese Physics B》 SCIE EI CAS CSCD 2012年第6期288-292,共5页
The signal synchronization transmission of a spatiotemporal chaos network is investigated. The structure of the coupling function between connected nodes of the complex network and the value range of the linear term c... The signal synchronization transmission of a spatiotemporal chaos network is investigated. The structure of the coupling function between connected nodes of the complex network and the value range of the linear term coefficient of the separated configuration in state equation of the node are obtained through constructing an appropriate Lyapunov function. Each node of the complex network is a laser spatiotemporal chaos model in which the phase-conjugate wave and the unilateral coupled map lattice are taken as a local function and a spatially extended system, respectively. The simulation results show the effectiveness of the signal synchronization transmission principle of the network. 展开更多
关键词 SYNCHRONIZATION complex network spatiotemporal chaos phase-conjugate wave
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Beam Coupling due to Self-Pumped Phase Conjugate Reflection in Photorefractive Crystals
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作者 孙秀冬 许克彬 +1 位作者 孙万钧 周忠祥 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 1995年第1期15-18,共4页
A novel configuration to produce bidirectional phase conjugate wave due to the self-pumping of one of two incident beams is experimentally investigated and analyzed with photorefractive KNSBN: Cu crystal. The phase co... A novel configuration to produce bidirectional phase conjugate wave due to the self-pumping of one of two incident beams is experimentally investigated and analyzed with photorefractive KNSBN: Cu crystal. The phase conjugate reflectivities and the response time are presented as functions of the ratio of input-beam intensities and the signal incident positions. 展开更多
关键词 ss: phase conjugation four-wave interaction dynamic volume grating
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Gas‐phase fluorination of conjugated microporous polymer microspheres for effective interfacial stabilization in lithium metal anodes
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作者 Zihao Li Lingchen Kong +1 位作者 Cong Peng Wei Feng 《Carbon Energy》 SCIE EI CAS CSCD 2023年第10期77-90,共14页
Lithium(Li)metal anodes have attracted extensive attention due to their ultrahigh theoretical capacity and low potential.However,the uneven deposition of Li near the unstable electrode/electrolyte interfaces leads to ... Lithium(Li)metal anodes have attracted extensive attention due to their ultrahigh theoretical capacity and low potential.However,the uneven deposition of Li near the unstable electrode/electrolyte interfaces leads to the growth of Li dendrites and the degradation of active electrodes.Herein,we directly fluorinate alkyne-containing conjugated microporous polymers(ACMPs)microspheres with fluorine gas(F_(2))to introduce a novel fluorinated interlayer as an interfacial stabilizer in lithium metal batteries.Using density functional theory methods,it is found that as-prepared fluorinated ACMP(FACMP)has abundant partially ionic C–F bonds.The C–F bonds with electrochemical lability yield remarkable lithiophilicity during cycling.The in situ reactions between the active C–F bonds and Li ions enable transfer of lithium fluoride microcrystals to the solid electrolyte interphase(SEI)layers,guaranteeing effective ionic distribution and smooth Li deposition.Consequently,Li metal electrodes with the fluorinated interlayers demonstrate excellent cycling performances in both half-batteries and full cells with a lithium bis(trifluoromethanesulfonyl)imide electrolyte as well as a nonfluorinated lithium bis(oxalate)borate electrolyte system.This strategy is highly significant in customizable SEI layers to stabilize electrode interfaces and ensure high utilization of Li metal anodes,especially in a nonfluorinated electrolyte. 展开更多
关键词 conjugated microporous polymers fluorinated solid electrolyte interphase gas‐phase fluorination lithium metal anodes nonfluorinated electrolyte
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Optical patterns in spatially coupled phase-conjugate systems
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作者 岳立娟 桑金玉 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第11期187-193,共7页
Various pattern evolutions are presented in one- and two-dimensional spatially coupled phase-conjugate systems (SCPCSs). As the system parameters change, different patterns are obtained from the period-doubling of k... Various pattern evolutions are presented in one- and two-dimensional spatially coupled phase-conjugate systems (SCPCSs). As the system parameters change, different patterns are obtained from the period-doubling of kink-antikinks in space to the spatiotemporal chaos in a one-dimensional SCPCS. The homogeneous symmetric states induce symmetry breaking from the four corners and the boundaries, finally leading to spatiotemporal chaos with the increase of the iteration time in a two-dimensional SCPCS. Numerical simulations are very helpful for understanding the complex optical phenomena. 展开更多
关键词 pattern evolution phase-conjugate one- and two-dimensional spatially systems
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Lattice Anchoring Stabilizesα-FAPbI_(3) Perovskite for High-Performance X-Ray Detectors
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作者 Yu-Hua Huang Su-Yan Zou +5 位作者 Cong-Yi Sheng Yu-Chuang Fang Xu-Dong Wang Wei Wei Wen-Guang Li Dai-Bin Kuang 《Nano-Micro Letters》 2026年第1期337-354,共18页
Formamidinium lead iodide(FAPbI_(3))perovskite exhibits an impressive X-ray absorption coefficient and a large carrier mobility-lifetime product(μτ),making it as a highly promising candidate for X-ray detection appl... Formamidinium lead iodide(FAPbI_(3))perovskite exhibits an impressive X-ray absorption coefficient and a large carrier mobility-lifetime product(μτ),making it as a highly promising candidate for X-ray detection application.However,the presence of larger FA^(+)cation induces to an expansion of the Pb-I octahedral framework,which unfortunately affects both the stability and charge carrier mobility of the corresponding devices.To address this challenge,we develop a novel low-dimensional(HtrzT)PbI_(3) perovskite featuring a conjugated organic cation(1H-1,2,4-Triazole-3-thiol,HtrzT^(+))which matches well with theα-FAPbI_(3) lattices in two-dimensional plane.Benefiting from the matched lattice between(HtrzT)PbI_(3) andα-FAPbI_(3),the anchored lattice enhances the Pb-I bond strength and effectively mitigates the inherent tensile strain of theα-FAPbI_(3) crystal lattice.The X-ray detector based on(HtrzT)PbI_(3)(1.0)/FAPbI_(3) device achieves a remarkable sensitivity up to 1.83×10^(5)μC Gy_(air)^(−1) cm^(−2),along with a low detection limit of 27.6 nGy_(air) s^(−1),attributed to the release of residual stress,and the enhancement in carrier mobility-lifetime product.Furthermore,the detector exhibits outstanding stability under X-ray irradiation with tolerating doses equivalent to nearly 1.17×10^(6) chest imaging doses. 展开更多
关键词 α-FAPbI_(3)perovskite conjugated organic cation Lattice anchoring phase stability X-ray detectors
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A Hermitian Opetator Conjugate to Two-Mode Number-Difference Operator
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作者 FAN Hong-yi WANG Yi-hua 《Chinese Physics Letters》 SCIE CAS CSCD 1998年第6期391-392,共2页
For the Shapiro-Wagner-Hradil phase detection description the canonical commutation relation between phase angleψand two-mode number-difference operator D=a^(†)a-b^(†)b is constructed.Departing from[ψ,D]=-i,the phas... For the Shapiro-Wagner-Hradil phase detection description the canonical commutation relation between phase angleψand two-mode number-difference operator D=a^(†)a-b^(†)b is constructed.Departing from[ψ,D]=-i,the phase angle Hermitian operator is derived in the newly obtained representation<ξ|,where|ξ>is the common eigenket of a+b^(†)and b+a^(†). 展开更多
关键词 OPERATOR conjugATE phase
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Research on Phase Detection of Liquid Crystal Optical Device
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作者 Mingliang Shi Ruofu Yang +2 位作者 Chunping Yang Mingwu Ao Hongzhou Dong 《Journal of Applied Mathematics and Physics》 2014年第12期1099-1104,共6页
The technology for phase detection of liquid crystal optical device is a difficult research in current domestic and overseas. However, for the existing liquid crystal optical device, aiming at the poor anti-vibration ... The technology for phase detection of liquid crystal optical device is a difficult research in current domestic and overseas. However, for the existing liquid crystal optical device, aiming at the poor anti-vibration capability and poor versatile of phase detection, the complexity of phase retrieval algorithm, we propose a new phase measurement principle and experimental methods of liquid crystal optical device. It is a phase measurement method based on the combination of phase- shifting interferometer and phase conjugation technology. The deflection characteristics of the liquid crystal device means the device can implement phase modulation to only one direction of polarized light while is completely transparent to orthogonal polarized light. We put forward the phase shift of the orthogonal polarization phase shift interferometer method, using phase shifting interference as well as the combination of phase conjugate means to achieve its phase measurement. So we can retrieves devices modulation phase simply and efficiently combines with phase- shifting interferometer technology. 展开更多
关键词 Liquid Crystal Optical Device Modulation phase Detection ORTHOGONAL phase SHIFTING conjugATE Interference phase RETRIEVAL Algorithm
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Highly Selective Molecular Recognition of Biologically Active Substances Using Liquid Phase Separation
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作者 MANO Nariyasu ASAKAWA Naoki +1 位作者 GOTO JunichiGraduate School of Pharmaceutical Sciences Tohoku University 《色谱》 CAS CSCD 北大核心 2003年第4期347-358,共12页
The development of new chiral stationary phases has been very important in the a ccurate analysis of drug enantiomers and their metabolites in biological samples during drug discovery and development. New chiral stati... The development of new chiral stationary phases has been very important in the a ccurate analysis of drug enantiomers and their metabolites in biological samples during drug discovery and development. New chiral stationary phases have been d eveloped using conalbumin and flavoprotein from chicken egg whites, which have b een applied to a broad range of drug enantiomers. The application and characteri zation of these two chiral columns for high-performance liquid chromatograp hy have been documented. Both specific and non-specific interactions, based on the silica gel surface and linker moiety, influenced retention and chiral separa tion of solutes. Interactions between drug enantiomers and proteins, as a pseudo chiral stationary phase, were investigated with affinity capillary electrophore sis, in order to avoid the effects of non-specific interactions. The chiral dis crimination region for ketoprofen on the flavoprotein surface was concluded to c onsist of an α-helix structure. Studies with chemically modified flavoprot ein indicated that two types of interactions at the chiral discrimination region were required for chiral separation: a π-π interaction between a tryptophan residue and the aromatic ring of ketoprofen, and an ionic interaction between th e carboxyl group of ketoprofen and an amino and carboxyl group of the protein. I n the bod y, drugs and biologically active substances having a carboxyl group have been kn own to transform various metabolites such as acyl glucuronide. The acyl adenylat e has also been noted as a chemically active intermediate of coenzyme A ligation . Both the acyl adenylate and the acyl glucuronide produced protein adducts by r eacting with nucleophilic groups such as amino groups on protein molecules. To c haracterize both active intermediates and protein adducts, analytical techniques conferring highly selective molecular recognition, such as high-performance li quid chromatography and mass spectrometry, were required. 展开更多
关键词 液相分离法 生物活性材料 分子识别 共轭蛋白质手性稳定相 亲和毛细管电泳 手性识别
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计算光学框架下的抗散射成像技术研究(特邀) 被引量:1
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作者 程雪岷 罗烈玉 +1 位作者 张泽森 郝群 《红外与激光工程》 北大核心 2025年第1期26-44,共19页
抗散射成像一直是光学成像领域的一个挑战性问题。数十年来,研究人员对此问题进行了广泛而深入的研究,并发展了多种方法和技术。文中综述了抗散射成像的基本原理、研究现状、不同方法的优势和局限性,以及潜在的发展方向。文中从计算光... 抗散射成像一直是光学成像领域的一个挑战性问题。数十年来,研究人员对此问题进行了广泛而深入的研究,并发展了多种方法和技术。文中综述了抗散射成像的基本原理、研究现状、不同方法的优势和局限性,以及潜在的发展方向。文中从计算光学的视角出发,对散射成像系统中各个模块的功能进行了分类,并将现有的抗散射成像技术分为六类进行详细介绍:弹道光提取技术、散斑相关成像、光子计数成像、散射补偿技术、计算光学成像技术和深度学习技术。其中,弹道光提取技术是最早的研究方向,随后对于光信息的利用逐渐深入,散斑相关成像,以及光子计数成像进入人们视野。而随着光学元件的发展,基于空间光调制器的散射补偿技术也引起了人们的关注。近年来,计算鬼成像技术因其独特的成像机制而成为新的研究焦点,并与深度学习技术一同推动了抗散射成像技术的进步。文中的内容旨在帮助研究人员理解各种抗散射成像技术的原理和最新进展,明确不同技术的特点和应用场景,以促进抗散射成像技术的进一步发展。 展开更多
关键词 抗散射成像 弹道光 光学相位共轭 计算鬼成像 深度学习
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A new circulating two-cell structure for stimulated Brillouin scattering phase conjugation mirrors with 1-J load and 10-Hz repetition rate 被引量:6
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作者 王雨雷 吕志伟 +3 位作者 郭琦 武鹏 郑振兴 何伟明 《Chinese Optics Letters》 SCIE EI CAS CSCD 2010年第11期1064-1066,共3页
A new approach to realize high-energy and high-power stimulated Brillouin scattering phase conjugation mirrors (SBS-PCMs) is described.The reflectivity of SBS-PCM is investigated under a 10-Hz repetition rate and a ... A new approach to realize high-energy and high-power stimulated Brillouin scattering phase conjugation mirrors (SBS-PCMs) is described.The reflectivity of SBS-PCM is investigated under a 10-Hz repetition rate and a high energy load.The relationship between reflectivity and input energy is examined experimentally with different PCM structures,focus lengths,and medium cell structures.A medium cell with a circulating structure is designed,and its advantage is demonstrated through an experimental comparison with traditional PCM structures.The 30-cm focus lens and 150-cm collimation lens are optimized when the input energy reaches 1010 mJ at 10-Hz repetition rate.Therefore,a reflectivity of 84.7% and a higher energy load using the circulating two-cell structure are achieved. 展开更多
关键词 Dynamic loads High energy physics Lenses Light polarization Mirrors Optical instruments Optical phase conjugation REFLECTION ULTRASONICS
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Optimized optical phase conjugation conf iguration for f iber nonlinearity compensation in CO-OFDM systems 被引量:2
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作者 李炉焦 乔耀军 纪越峰 《Chinese Optics Letters》 SCIE EI CAS CSCD 2011年第6期31-35,共5页
The optimized optical phase conjugation (OPC) configuration is proposed for the 40-Gb/s CO-OFDM system. The proposed configuration for nonlinear cancellation is systematically depicted in transmission links with lum... The optimized optical phase conjugation (OPC) configuration is proposed for the 40-Gb/s CO-OFDM system. The proposed configuration for nonlinear cancellation is systematically depicted in transmission links with lumped amplification. Numerical simulations are performed to demonstrate effectiveness. Simulation results show that mid-span spectral inversion (MSSI) can partially compensate for nonlinear distortions. Moreover, its optimized configuration can further improve system performances and increase nonlinear compensation effectiveness. Compared with MSSI, the maximal Q factor, nonlinear threshold, and transmission distance of optimized OPC configuration increase by over 1.6 dB, 2 dB, and 2 times, respectively. 展开更多
关键词 Optical phase conjugation OPTIMIZATION Telecommunication systems
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Optimization of compensation for high spatial frequency in distorted wavefront using optical phase conjugation 被引量:2
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作者 Pan Zhang Dean Liu +1 位作者 Aihua Yang Jianqiang Zhu 《Chinese Optics Letters》 SCIE EI CAS CSCD 2019年第7期34-37,共4页
A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation.Based on the coupled-wave equ... A method is proposed to optimize the recording structure of the photorefractive volume grating to compensate high spatial frequency in the distorted wavefront by optical phase conjugation.Based on the coupled-wave equation, the diffraction efficiency of the recorded grating formed by the scattered beams in different recording structures is simulated.The theoretical results show that the recorded modulations with high spatial frequency can be significantly improved in the small recording angle.In the experiment, three recording structures with the recording angles of 7.5°, 30°, and 45° are chosen to verify the compensation effect.Compared with the reconstructed image in the large recording angle of 45°, the signal to noise ratio of the image recorded at 7.5° increases to 3.2 times of that at 45°. 展开更多
关键词 OPTIMIZATION of COMPENSATION HIGH SPATIAL frequency optical phase conjugation
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Control of polarization signal distortion by frequency domain phase conjugation in optical fiber systems 被引量:1
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作者 BU Yang WANG XiangZhao 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2008年第5期512-518,共7页
Optical frequency domain phase conjugation(FDPC) is based on phase conjuga-tion of spectrum of an input signal.It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signa... Optical frequency domain phase conjugation(FDPC) is based on phase conjuga-tion of spectrum of an input signal.It is equivalent to the phase conjugation and the time reversal of the temporal envelope of an input signal.The use of FDPC to con-trol polarization signal distortion in birefringent optical fiber systems is proposed.Evolution of polarization signals in the system using midway FDPC is analyzed theoretically and simulated numerically.It is shown that the distortion of polariza-tion signals can be controlled effectively by FDPC.The impairments due to disper-sion and nonlinear effects can be suppressed simultaneously. 展开更多
关键词 FREQUENCY DOMAIN phase conjugation POLARIZATION DISPERSION nonlinear effects
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“两步法”合成基于二硫键连接子的奥曲肽-阿霉素偶联物 被引量:1
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作者 于千尧 孟铭 +2 位作者 姚景方 杜姗姗 齐昀坤 《化学学报》 北大核心 2025年第4期341-353,共13页
癌症仍然是一个全球性的健康挑战,开发具有新骨架的新型抗癌药物具有重要意义.多肽-药物偶联物(PDCs)是新型靶向抗癌药物,具有对肿瘤组织穿透性强、生产成本低及易于结构改造等优势,可显著提高细胞毒性药物的靶向性和抗肿瘤活性.奥曲肽... 癌症仍然是一个全球性的健康挑战,开发具有新骨架的新型抗癌药物具有重要意义.多肽-药物偶联物(PDCs)是新型靶向抗癌药物,具有对肿瘤组织穿透性强、生产成本低及易于结构改造等优势,可显著提高细胞毒性药物的靶向性和抗肿瘤活性.奥曲肽是一种可特异性靶向肿瘤细胞表面生长抑素受体2(SSTR2)的环肽,在PDCs药物研发中得到广泛应用.二硫键是PDCs分子中常用的可裂解连接基团.以往合成含有二硫键连接子的奥曲肽-小分子药物偶联物一般采用“三步法”策略,但合成路线繁琐且产率较低.基于此,本研究开发了“两步法”合成策略,即先在固相上合成含有分子内二硫键和巯基末端的奥曲肽衍生物,再通过液相反应与含有巯基的小分子药物共价偶联.为了实现含巯基末端奥曲肽的高效合成,本研究探索了不同的固相缩合路线和切肽体系,综合考虑色谱纯度和分离收率等,筛选出最佳合成路线SPPS-2和最优切肽体系.为了进一步验证SPPS-2合成路线的普适性,探讨了不同树脂和切肽时间对合成效率的影响.固相高效合成巯基奥曲肽(OCT-SH)后,将化疗药物阿霉素(DOX)通过液相反应与OCT-SH共价偶联,形成奥曲肽-阿霉素偶联物.体外抗肿瘤实验表明,奥曲肽-阿霉素偶联物具有较强的抗肿瘤活性,可以显著降低阿霉素对正常细胞的毒性并实现对肿瘤细胞的高选择性.细胞摄取实验表明,阿霉素的共价偶联对奥曲肽的细胞摄取能力没有明显影响.本研究利用“两步法”合成策略,建立了最佳的固相缩合路线和切肽体系,实现了基于二硫键连接子的奥曲肽-阿霉素偶联物的高效合成.本研究为固相合成含有多对二硫键的PDCs分子提供了重要参考,为开发新型抗肿瘤药物提供了启发. 展开更多
关键词 固相多肽合成 二硫键 多肽-药物偶联物 奥曲肽 阿霉素 巯基
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