针对电力领域文本数据分词准确性较低的问题,提出一种基于改进ADAM(adaptive moment estimation)算法的中文分词技术。选用Skip-Gram模型作为字嵌入模型,将字词转为分布式向量,搭建卷积神经网络-门控循环单元-条件随机场(CNN-Bi-GRU-CRF...针对电力领域文本数据分词准确性较低的问题,提出一种基于改进ADAM(adaptive moment estimation)算法的中文分词技术。选用Skip-Gram模型作为字嵌入模型,将字词转为分布式向量,搭建卷积神经网络-门控循环单元-条件随机场(CNN-Bi-GRU-CRF)模型实现电力领域文本语句的分割,提出一种改进的ADAM算法,通过控制不同时间窗口的学习率优化神经网络模型,提高模型训练速度。将所提算法运用于变电站SCD(system configuration description)文本数据分词的算例分析,通过与其他主流分词算法进行比较,验证所提分词技术的先进性与准确性。展开更多
Cancer stem cells(CSCs)are widely acknowledged as primary mediators to the initiation and progression of tumors.The association between microbial infection and cancer stemness has garnered considerable scholarly inter...Cancer stem cells(CSCs)are widely acknowledged as primary mediators to the initiation and progression of tumors.The association between microbial infection and cancer stemness has garnered considerable scholarly interest in recent years.Porphyromonas gingivalis(P.gingivalis)is increasingly considered to be closely related to the development of oral squamous cell carcinoma(OSCC).Nevertheless,the role of P.gingivalis in the stemness of OSCC cells remains uncertain.Herein,we showed that P.gingivalis was positively correlated with CSC markers expression in human OSCC specimens,promoted the stemness and tumorigenicity of OSCC cells,and enhanced tumor formation in nude mice.Mechanistically,P.gingivalis increased lipid synthesis in OSCC cells by upregulating the expression of stearoyl-CoA desaturase 1(SCD1)expression,a key enzyme involved in lipid metabolism,which ultimately resulted in enhanced acquisition of stemness.Moreover,SCD1 suppression attenuated P.gingivalis-induced stemness of OSCC cells,including CSCs markers expression,sphere formation ability,chemoresistance,and tumor growth,in OSCC cells both in vitro and in vivo.Additionally,upregulation of SCD1 in P.gingivalis-infected OSCC cells was associated with the expression of KLF5,and that was modulated by P.gingivalis-activated NOD1 signaling.Taken together,these findings highlight the importance of SCD1-dependent lipid synthesis in P.gingivalis-induced stemness acquisition in OSCC cells,suggest that the NOD1/KLF5 axis may play a key role in regulating SCD1 expression and provide a molecular basis for targeting SCD1 as a new option for attenuating OSCC cells stemness.展开更多
文摘针对电力领域文本数据分词准确性较低的问题,提出一种基于改进ADAM(adaptive moment estimation)算法的中文分词技术。选用Skip-Gram模型作为字嵌入模型,将字词转为分布式向量,搭建卷积神经网络-门控循环单元-条件随机场(CNN-Bi-GRU-CRF)模型实现电力领域文本语句的分割,提出一种改进的ADAM算法,通过控制不同时间窗口的学习率优化神经网络模型,提高模型训练速度。将所提算法运用于变电站SCD(system configuration description)文本数据分词的算例分析,通过与其他主流分词算法进行比较,验证所提分词技术的先进性与准确性。
基金supported by the National Natural Science Foundation of China(grant#82370975 and 82170969)。
文摘Cancer stem cells(CSCs)are widely acknowledged as primary mediators to the initiation and progression of tumors.The association between microbial infection and cancer stemness has garnered considerable scholarly interest in recent years.Porphyromonas gingivalis(P.gingivalis)is increasingly considered to be closely related to the development of oral squamous cell carcinoma(OSCC).Nevertheless,the role of P.gingivalis in the stemness of OSCC cells remains uncertain.Herein,we showed that P.gingivalis was positively correlated with CSC markers expression in human OSCC specimens,promoted the stemness and tumorigenicity of OSCC cells,and enhanced tumor formation in nude mice.Mechanistically,P.gingivalis increased lipid synthesis in OSCC cells by upregulating the expression of stearoyl-CoA desaturase 1(SCD1)expression,a key enzyme involved in lipid metabolism,which ultimately resulted in enhanced acquisition of stemness.Moreover,SCD1 suppression attenuated P.gingivalis-induced stemness of OSCC cells,including CSCs markers expression,sphere formation ability,chemoresistance,and tumor growth,in OSCC cells both in vitro and in vivo.Additionally,upregulation of SCD1 in P.gingivalis-infected OSCC cells was associated with the expression of KLF5,and that was modulated by P.gingivalis-activated NOD1 signaling.Taken together,these findings highlight the importance of SCD1-dependent lipid synthesis in P.gingivalis-induced stemness acquisition in OSCC cells,suggest that the NOD1/KLF5 axis may play a key role in regulating SCD1 expression and provide a molecular basis for targeting SCD1 as a new option for attenuating OSCC cells stemness.
