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基于转录组学和细胞实验验证探究药根碱对结直肠癌细胞SAT1介导的铁死亡的调控作用
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作者 李智育 王松玲 +3 位作者 张雯 代欣宇 周明明 彭海燕 《中国中药杂志》 北大核心 2026年第1期153-162,共10页
探讨黄连提取物药根碱(JAT)通过亚精胺/精胺N1-乙酰转移酶1(SAT1)对人结直肠癌(CRC)HT29和HCT116细胞诱导P53介导的铁死亡的影响。采用cell counting kit-8 (CCK-8)法检测细胞活力;平板克隆实验检测细胞增殖能力;流式细胞术检测细胞周期... 探讨黄连提取物药根碱(JAT)通过亚精胺/精胺N1-乙酰转移酶1(SAT1)对人结直肠癌(CRC)HT29和HCT116细胞诱导P53介导的铁死亡的影响。采用cell counting kit-8 (CCK-8)法检测细胞活力;平板克隆实验检测细胞增殖能力;流式细胞术检测细胞周期;JC-1染料检测线粒体膜电位;用高通量转录组测序(RNA-seq)技术分析JAT处理后HT29和HCT116细胞基因变化。利用慢病毒转染技术构建SAT1过表达HCT116和HT29细胞株,实时荧光定量聚合酶链式反应(real-time qPCR)实验检测转染效率。Fe^(2+)、活性氧(ROS)、脂质氧化(MDA)、谷胱甘肽(GSH)检测试剂盒检测CRC细胞株中Fe^(2+)、ROS、MDA、GSH表达,蛋白免疫印迹(WB)和qPCR检测胱氨酸/谷氨酸反向转运蛋白(SLC7A11)、谷胱甘肽过氧化物酶4(GPX4)、酰基辅酶A合成酶长链家族成员4(ACSL4)、肿瘤蛋白P53(P53)、SAT1蛋白和mRNA在CRC细胞株中的表达。结果显示,JAT可以抑制HCT116和HT29细胞活力和增殖,诱导细胞周期停滞,降低线粒体膜电位。转录组测序可知JAT对HCT116和HT29细胞主要富集的KEGG通路有蛋白质消化和吸收,精氨酸和脯氨酸代谢,甘氨酸、丝氨酸和苏氨酸代谢,铁死亡等。其中精氨酸代谢途径中的SAT1经JAT处理后mRNA显著上调。且JAT处理后各剂量组在HCT116和HT29细胞中Fe^(2+)、ROS、MDA水平升高,GSH含量明显降低,SLC7A11、GPX4蛋白表达降低,ACSL4、SAT1、P53蛋白表达升高。SAT1过表达后的2种CRC细胞株可抑制细胞的增殖,并可激活P53诱导的铁死亡信号通路,而转染SAT1过表达慢病毒(oveSAT1)+JAT组相较于oveSAT1组有更好的效果。综上,JAT可通过上调脯氨酸代谢中SAT1关键分子蛋白激活P53诱导的铁死亡信号通路。 展开更多
关键词 药根碱 结直肠癌 铁死亡 sat1
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优化概率选择求解SAT问题
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作者 贾书恒 付慧敏 《计算机科学》 北大核心 2026年第3期366-374,共9页
在SAT问题的随机局部搜索算法中,主流变量决策策略基于概率选择变量,如probSAT求解器通过计算变量的break值确定选择概率。然而,该方法易陷入局部最优,尤其在应用类问题中表现不佳。为此,提出了一种结合配置检测策略的变量决策方法,动... 在SAT问题的随机局部搜索算法中,主流变量决策策略基于概率选择变量,如probSAT求解器通过计算变量的break值确定选择概率。然而,该方法易陷入局部最优,尤其在应用类问题中表现不佳。为此,提出了一种结合配置检测策略的变量决策方法,动态调整变量选择概率函数。当环境不变时,优先选择break值较低的变量,增强全局优化能力。针对长子句的高扫描开销问题,引入重要邻居数组策略,将高活跃度变量纳入数组,降低计算复杂度。同时,设计了重启机制,利用probSAT在初期快速降低不可满足子句数量的优势,避免后期全局重复翻转现象,提升求解效率。改进后的probSAT_PCCR求解器在长期未解决的数学应用问题测试中表现显著提升,比原始probSAT多解决了142个案例,性能提升546.1%。在美国联邦通信委员会(FCC)的实际应用问题测试中,多解决了1596个案例,性能提升33.5%。结果表明,通过多种策略改进的probSAT求解器在解决SAT问题的应用类问题上性能大幅提升,具有重要应用价值。 展开更多
关键词 配置检测 重要邻居数组 可满足性问题 sat求解器 变量决策策略
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Context Patch Fusion with Class Token Enhancement for Weakly Supervised Semantic Segmentation
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作者 Yiyang Fu Hui Li Wangyu Wu 《Computer Modeling in Engineering & Sciences》 2026年第1期1130-1150,共21页
Weakly Supervised Semantic Segmentation(WSSS),which relies only on image-level labels,has attracted significant attention for its cost-effectiveness and scalability.Existing methods mainly enhance inter-class distinct... Weakly Supervised Semantic Segmentation(WSSS),which relies only on image-level labels,has attracted significant attention for its cost-effectiveness and scalability.Existing methods mainly enhance inter-class distinctions and employ data augmentation to mitigate semantic ambiguity and reduce spurious activations.However,they often neglect the complex contextual dependencies among image patches,resulting in incomplete local representations and limited segmentation accuracy.To address these issues,we propose the Context Patch Fusion with Class Token Enhancement(CPF-CTE)framework,which exploits contextual relations among patches to enrich feature repre-sentations and improve segmentation.At its core,the Contextual-Fusion Bidirectional Long Short-Term Memory(CF-BiLSTM)module captures spatial dependencies between patches and enables bidirectional information flow,yield-ing a more comprehensive understanding of spatial correlations.This strengthens feature learning and segmentation robustness.Moreover,we introduce learnable class tokens that dynamically encode and refine class-specific semantics,enhancing discriminative capability.By effectively integrating spatial and semantic cues,CPF-CTE produces richer and more accurate representations of image content.Extensive experiments on PASCAL VOC 2012 and MS COCO 2014 validate that CPF-CTE consistently surpasses prior WSSS methods. 展开更多
关键词 Weakly supervised semantic segmentation context-fusion class enhancement
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Cascading Class Activation Mapping:A Counterfactual Reasoning-Based Explainable Method for Comprehensive Feature Discovery
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作者 Seoyeon Choi Hayoung Kim Guebin Choi 《Computer Modeling in Engineering & Sciences》 2026年第2期1043-1069,共27页
Most Convolutional Neural Network(CNN)interpretation techniques visualize only the dominant cues that the model relies on,but there is no guarantee that these represent all the evidence the model uses for classificati... Most Convolutional Neural Network(CNN)interpretation techniques visualize only the dominant cues that the model relies on,but there is no guarantee that these represent all the evidence the model uses for classification.This limitation becomes critical when hidden secondary cues—potentially more meaningful than the visualized ones—remain undiscovered.This study introduces CasCAM(Cascaded Class Activation Mapping)to address this fundamental limitation through counterfactual reasoning.By asking“if this dominant cue were absent,what other evidence would the model use?”,CasCAM progressively masks the most salient features and systematically uncovers the hierarchy of classification evidence hidden beneath them.Experimental results demonstrate that CasCAM effectively discovers the full spectrum of reasoning evidence and can be universally applied with nine existing interpretation methods. 展开更多
关键词 Explainable AI class activation mapping counterfactual reasoning shortcut learning feature discovery
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Flood predictions from metrics to classes by multiple machine learning algorithms coupling with clustering-deduced membership degree
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作者 ZHAI Xiaoyan ZHANG Yongyong +5 位作者 XIA Jun ZHANG Yongqiang TANG Qiuhong SHAO Quanxi CHEN Junxu ZHANG Fan 《Journal of Geographical Sciences》 2026年第1期149-176,共28页
Accurate prediction of flood events is important for flood control and risk management.Machine learning techniques contributed greatly to advances in flood predictions,and existing studies mainly focused on predicting... Accurate prediction of flood events is important for flood control and risk management.Machine learning techniques contributed greatly to advances in flood predictions,and existing studies mainly focused on predicting flood resource variables using single or hybrid machine learning techniques.However,class-based flood predictions have rarely been investigated,which can aid in quickly diagnosing comprehensive flood characteristics and proposing targeted management strategies.This study proposed a prediction approach of flood regime metrics and event classes coupling machine learning algorithms with clustering-deduced membership degrees.Five algorithms were adopted for this exploration.Results showed that the class membership degrees accurately determined event classes with class hit rates up to 100%,compared with the four classes clustered from nine regime metrics.The nonlinear algorithms(Multiple Linear Regression,Random Forest,and least squares-Support Vector Machine)outperformed the linear techniques(Multiple Linear Regression and Stepwise Regression)in predicting flood regime metrics.The proposed approach well predicted flood event classes with average class hit rates of 66.0%-85.4%and 47.2%-76.0%in calibration and validation periods,respectively,particularly for the slow and late flood events.The predictive capability of the proposed prediction approach for flood regime metrics and classes was considerably stronger than that of hydrological modeling approach. 展开更多
关键词 flood regime metrics class prediction machine learning algorithms hydrological model
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CAWASeg:Class Activation Graph Driven Adaptive Weight Adjustment for Semantic Segmentation
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作者 Hailong Wang Minglei Duan +1 位作者 Lu Yao Hao Li 《Computers, Materials & Continua》 2026年第3期1071-1091,共21页
In image analysis,high-precision semantic segmentation predominantly relies on supervised learning.Despite significant advancements driven by deep learning techniques,challenges such as class imbalance and dynamic per... In image analysis,high-precision semantic segmentation predominantly relies on supervised learning.Despite significant advancements driven by deep learning techniques,challenges such as class imbalance and dynamic performance evaluation persist.Traditional weighting methods,often based on pre-statistical class counting,tend to overemphasize certain classes while neglecting others,particularly rare sample categories.Approaches like focal loss and other rare-sample segmentation techniques introduce multiple hyperparameters that require manual tuning,leading to increased experimental costs due to their instability.This paper proposes a novel CAWASeg framework to address these limitations.Our approach leverages Grad-CAM technology to generate class activation maps,identifying key feature regions that the model focuses on during decision-making.We introduce a Comprehensive Segmentation Performance Score(CSPS)to dynamically evaluate model performance by converting these activation maps into pseudo mask and comparing them with Ground Truth.Additionally,we design two adaptive weights for each class:a Basic Weight(BW)and a Ratio Weight(RW),which the model adjusts during training based on real-time feedback.Extensive experiments on the COCO-Stuff,CityScapes,and ADE20k datasets demonstrate that our CAWASeg framework significantly improves segmentation performance for rare sample categories while enhancing overall segmentation accuracy.The proposed method offers a robust and efficient solution for addressing class imbalance in semantic segmentation tasks. 展开更多
关键词 Semantic segmentation class activation graph adaptive weight adjustment pseudo mask
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Effective Token Masking Augmentation Using Term-Document Frequency for Language Model-Based Legal Case Classification
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作者 Ye-Chan Park Mohd Asyraf Zulkifley +1 位作者 Bong-Soo Sohn Jaesung Lee 《Computers, Materials & Continua》 2026年第4期928-945,共18页
Legal case classification involves the categorization of legal documents into predefined categories,which facilitates legal information retrieval and case management.However,real-world legal datasets often suffer from... Legal case classification involves the categorization of legal documents into predefined categories,which facilitates legal information retrieval and case management.However,real-world legal datasets often suffer from class imbalances due to the uneven distribution of case types across legal domains.This leads to biased model performance,in the form of high accuracy for overrepresented categories and underperformance for minority classes.To address this issue,in this study,we propose a data augmentation method that masks unimportant terms within a document selectively while preserving key terms fromthe perspective of the legal domain.This approach enhances data diversity and improves the generalization capability of conventional models.Our experiments demonstrate consistent improvements achieved by the proposed augmentation strategy in terms of accuracy and F1 score across all models,validating the effectiveness of the proposed method in legal case classification. 展开更多
关键词 Legal case classification class imbalance data augmentation token masking legal NLP
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随机正则3-(d,k)-SAT问题的可满足性相变
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作者 王晓峰 唐傲 +4 位作者 彭庆媛 颜冬 华盈盈 何飞 王军霞 《华中科技大学学报(自然科学版)》 北大核心 2025年第10期42-48,83,共8页
受随机正则恰当(d,k)-SAT(可满足性)问题的特征启发,提出了随机正则3-(d,k)-SAT问题.首先,引入了随机正则3-(d,k)-SAT问题实例生成模型,用于产生随机正则(d,k)-CNF(合取范式)公式.该模型采用完美匹配机制,每个随机完美匹配都对应一个随... 受随机正则恰当(d,k)-SAT(可满足性)问题的特征启发,提出了随机正则3-(d,k)-SAT问题.首先,引入了随机正则3-(d,k)-SAT问题实例生成模型,用于产生随机正则(d,k)-CNF(合取范式)公式.该模型采用完美匹配机制,每个随机完美匹配都对应一个随机正则3-(d,k)-SAT实例.然后,结合一阶矩方法、二阶矩方法和正则(d,k)-CNF公式的解空间结构,给出了当k>3时,随机正则3-(d,k)-SAT问题的可满足性相变点dk.当d>dk时,随机正则(d,k)-CNF实例公式高概率3-恰当不可满足;当d<dk时,随机正则(d,k)-CNF实例公式高概率3-恰当可满足.最后,分别取变元规模n=10,k=6和n=15,k=10的两组数据集进行实验.实验结果表明:随机正则3-(d,k)-SAT问题存在相变现象,分别发生在d_(6)=1.407 4和d_(10)=1.962 4附近,验证了理论证明所得相变点的正确性. 展开更多
关键词 相变现象 随机正则3-(d k)-sat问题 矩方法 正则(d k)-CNF公式 生成模型
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Orthodontic camouflage versus orthognathic surgery: A comparative analysis of long-term stability and satisfaction in moderate skeletal Class III 被引量:1
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作者 Xueyan Xiong Yaxin Yu Fengshan Chen 《Open Journal of Stomatology》 2013年第1期89-93,共5页
Objective: The purpose of this study was to compare long-term stability and satisfaction between orthodontic camouflage and orthognathic surgery in treatment of moderate skeletal Class III adults. Materials and Method... Objective: The purpose of this study was to compare long-term stability and satisfaction between orthodontic camouflage and orthognathic surgery in treatment of moderate skeletal Class III adults. Materials and Methods: A total of 25 adults females who had been treated with orthodontic camouflage for Class III malocclusions were recalled at least 3 years post-treatment to evaluate stability and satisfaction with treatment outcomes. The data were compared with similar data for long-term outcomes in 21 patients with the same Class III problems who had bimaxillary surgical correction. Results: In the camouflage patients, small mean changes in skeletal landmark positions occurred over the long term, although the changes were generally much smaller than in the surgery patients. Dental changes in the surgery group were more severe than those in the camouflage group. The camouflage patients reported fewer functional or temporomandibular joint problems than did the surgery patients. Both groups reported similar levels of overall satisfaction with treatment. Conclusion: The results suggest that both camouflage and surgical treatment in moderate skeletal Class III adults can achieve satisfactory outcomes and provide long-term stability. If patients do not readily accept surgery because of potential surgical complications or financial difficulties, camouflage treatment may be an effective alternative treatment. 展开更多
关键词 MODERATE SKELETAL class III Adults ORTHODONTIC CAMOUFLAGE ORTHOGNATHIC Surgery
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基于SAT的WARP算法的代数攻击
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作者 郝春雨 徐洪 《密码学报(中英文)》 北大核心 2025年第2期283-296,共14页
WARP算法是由Banik等人在SAC2020会议上提出的一种轻量级分组密码算法,具有极低的硬件成本,可以作为AES-128算法的轻量级代替.本文基于SAT方法研究了对WARP算法的代数攻击,在代数攻击模型的构建上,提出WARP算法线性运算和非线性运算的... WARP算法是由Banik等人在SAC2020会议上提出的一种轻量级分组密码算法,具有极低的硬件成本,可以作为AES-128算法的轻量级代替.本文基于SAT方法研究了对WARP算法的代数攻击,在代数攻击模型的构建上,提出WARP算法线性运算和非线性运算的不同建模方式,并根据SAT模型的特点,利用多种预处理技术简化模型,提高求解效率.在求解SAT模型时,分析了当密钥变元重量、明密文对数和密钥穷举量不同时相应SAT模型的求解效率.利用这些方法,通过穷举40比特密钥,使用60对具有差分结构的明密文进行代数攻击,在约2^(53.28) s内,可以恢复15轮WARP算法的全部128比特密钥. 展开更多
关键词 WARP 轻量级分组密码 代数攻击 sat
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顺序编码方法优化与SAT搜索应用
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作者 颜国华 张凤荣 +2 位作者 崔笑 韦永壮 王保仓 《密码学报(中英文)》 北大核心 2025年第4期894-910,共17页
自动搜索技术在密码分析中起着越来越重要的作用,SAT搜索技术是目前常用的搜索技术之一.为了更好地使得SAT搜索方法应用于密码分析领域并提高搜索效率,本文提出新的构造SAT模型方法.首先,提出一种新的k输入异或模型,在产生4·(k−1)&... 自动搜索技术在密码分析中起着越来越重要的作用,SAT搜索技术是目前常用的搜索技术之一.为了更好地使得SAT搜索方法应用于密码分析领域并提高搜索效率,本文提出新的构造SAT模型方法.首先,提出一种新的k输入异或模型,在产生4·(k−1)·n个句子情况下,引入变量减少至[(k−3)2]·n.其次,对约束目标函数的顺序编码方法改进,提出了两种新的顺序编码方法,两种方法引入的辅助变量分别减少至(n−k−1/2)·k和(n−k)·k.进一步地,根据新的顺序编码方法提出新的定界条件编码方法,将Matsui定界条件引入SAT模型加速搜索.最后,本文将新的构造SAT模型方法应用于FBC、SMS4和PRESENT等密码算法的最小活跃S盒搜索,给出相应缩减轮密码算法的最小活跃S盒数量. 展开更多
关键词 分组密码 差分分析 自动搜索 sat方法
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Information System/Information Technology Strategic Planning in Order Information Technology Development Strategy Using TOGAF (The Open Group Architecture Framework) Methodology in Achieving World Class University in Satya Wacana Christian University
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作者 Augie David Manuputty Agustinus Fritz Wijaya 《Intelligent Information Management》 2013年第6期175-181,共7页
Information systems and information technology (IS/IT) play an important role in supporting the organization to conduct its business processes. The research was conducted at the University of Satya Christian Wacana (S... Information systems and information technology (IS/IT) play an important role in supporting the organization to conduct its business processes. The research was conducted at the University of Satya Christian Wacana (SWCU). Business processes in perceived walking SWCU are not optimal in using IS/IT in the organization. The planning process/IT has not been done in all business units and SWCU does not have an Executive Information System that can help in the decision making process. The process of strategic planning of information systems and information technology using The Open Group Architecture Framework (TOGAF) has compiled a few methods of strategic planning. The results obtained by the study of the needs of IS/IT in SWCU generating application portfolio will be implemented in the institution. 展开更多
关键词 INFORMATION Systems INFORMATION TECHNOLOGY Strategic Planning World class UNIVERSITY TOGAF
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基于CLASS的师幼互动质量评估研究 被引量:4
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作者 金芳 富建业 《贵州师范学院学报》 2025年第5期39-48,共10页
通过元分析对中国2017年1月至2024年4月期间的师幼互动质量进行了深入探讨,并基于CLASS工具对1389份样本数据进行了综合评估。研究发现,中国师幼互动在情感支持领域表现良好,尤其在积极氛围维度上得分较高,但在教育支持领域,尤其是认知... 通过元分析对中国2017年1月至2024年4月期间的师幼互动质量进行了深入探讨,并基于CLASS工具对1389份样本数据进行了综合评估。研究发现,中国师幼互动在情感支持领域表现良好,尤其在积极氛围维度上得分较高,但在教育支持领域,尤其是认知发展方面存在不足。研究还揭示了师幼互动质量在地区、年龄班及活动领域的显著差异:北部地区、大班及社会领域的师幼互动质量较高;而西部和南部地区、中班及艺术与语言领域的互动质量则相对较低。最后,提出了加强幼儿认知与创造性思维培养、优化教育氛围、强化幼儿主体性以及差异化优化师幼互动的策略。研究结果为改善幼儿园教育实践和政策制定提供了数据支持和方向指导。 展开更多
关键词 师幼互动质量 元分析 class评估
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AngⅡ激活p53/SAT1信号通路诱导白色脂肪细胞铁死亡
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作者 邓伟 刘喜燕 +9 位作者 郭丽媛 徐倩 周坤 赵元琴 王昭月 李想 邓新梅 秦昕怡 任重 姜志胜 《中国动脉硬化杂志》 2025年第5期385-394,共10页
[目的]探讨血管紧张素Ⅱ(AngⅡ)对白色脂肪细胞铁死亡的影响及其机制。[方法]通过诱导物刺激的方法使3T3-L1脂肪前体细胞向白色脂肪细胞分化,实验分为对照组、AngⅡ组、AngⅡ+Fer-1(铁死亡抑制剂)组和AngⅡ+PFT-α(p53抑制剂)组。使用An... [目的]探讨血管紧张素Ⅱ(AngⅡ)对白色脂肪细胞铁死亡的影响及其机制。[方法]通过诱导物刺激的方法使3T3-L1脂肪前体细胞向白色脂肪细胞分化,实验分为对照组、AngⅡ组、AngⅡ+Fer-1(铁死亡抑制剂)组和AngⅡ+PFT-α(p53抑制剂)组。使用AngⅡ处理细胞,利用RT-qPCR和Western blot检测细胞铁死亡因子和脂肪因子表达水平,JC-1试剂盒检测线粒体膜电位(MMP)水平,铁离子试剂盒检测细胞内铁含量,谷胱甘肽(GSH)试剂盒检测GSH含量。加入Fer-1和AngⅡ处理细胞,检测细胞铁死亡水平变化。检测p53和亚精胺/精胺N1-乙酰转移酶1(SAT1)蛋白表达。随后加入PFT-α和AngⅡ共处理细胞,检测p53和SAT1蛋白表达变化,观察抑制p53表达对细胞铁死亡因子和脂肪因子表达水平的影响。[结果]通过刺激物诱导分化法成功将3T3-L1细胞分化为白色脂肪细胞。AngⅡ诱导白色脂肪细胞发生铁死亡。RT-qPCR结果显示,与对照组相比,AngⅡ组的抗铁死亡因子谷胱甘肽过氧化物酶4(GPX4)、溶质载体家族7成员11(SLC7A11)和铁调节蛋白1(IRP-1)的mRNA表达均下调,促铁死亡因子酯酰辅酶A合成酶长链家族成员4(ACSL4)的mRNA表达上调。Western blot结果显示,与对照组相比,AngⅡ组的SLC7A11和GPX4的蛋白表达均下调,ACSL4的蛋白表达上调。AngⅡ处理使细胞内铁离子的含量增加,GSH和MMP水平下降。与AngⅡ组相比,AngⅡ+Fer-1组的IRP-1和SLC7A11的mRNA表达均上调。AngⅡ诱导白色脂肪细胞的脂肪因子表达谱改变。Western blot结果显示,与对照组相比,AngⅡ组的促炎脂肪因子瘦素(LEP)、抵抗素(RETN)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)的蛋白表达均上调,抗炎脂肪因子脂联素(ADPN)和网膜素1(ITLN1)的蛋白表达下调。此外,AngⅡ使p53和SAT1蛋白表达增加。抑制p53表达可改善AngⅡ处理下白色脂肪细胞的铁死亡水平和脂肪因子表达水平。Western blot结果显示,与AngⅡ组相比,AngⅡ+PFT-α组的p53和SAT1蛋白表达下调,SLC7A11和GPX4蛋白表达上调,ACSL4蛋白表达下调;AngⅡ+PFT-α组的ADPN蛋白表达上调,TNF-α、LEP和RETN的蛋白表达均下调。[结论]AngⅡ通过激活p53/SAT1信号通路诱导白色脂肪细胞铁死亡。 展开更多
关键词 白色脂肪组织 血管紧张素Ⅱ 铁死亡 p53/sat1信号通路
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ON SATURATION CLASS FOR JACKSON SUMES OF BESSEL SERIES
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作者 Mu Lehua (Shandong University, China) 《Approximation Theory and Its Applications》 2002年第2期33-41,共9页
Let function f(z) be analytic in |z| <1 and continuous on |z |≤1. The saturation class for the Jackson sums of the Bessel series of f(z) is discussed.
关键词 ON satURATION class FOR JACKSON SUMES OF BESSEL SERIES ZN
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The Teaching Mode Research of“Internet Plus Flipped Class”——Taking the Course of Satellite Meteorology as Example
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作者 Xiehui Li Lei Wang 《Review of Educational Theory》 2020年第3期1-4,共4页
Based on the existing disadvantages of traditional teaching mode of Satellite Meteorology course in Chengdu University of Information Technology and the new teaching mode overview of“Internet Plus flipped class”,thi... Based on the existing disadvantages of traditional teaching mode of Satellite Meteorology course in Chengdu University of Information Technology and the new teaching mode overview of“Internet Plus flipped class”,this paper is mainly to construct flipped class teaching mode of Satellite Meteorology under the background of“Internet Plus”in Chengdu University of Information Technology.Through the Internet,it also tries to integrate this teaching mode into flipped class before class,in class,after class,which means to provide a new thought for the teaching of this course in colleges and universities. 展开更多
关键词 “Internet Plus” Flipped class satellite Meteorology The teaching mode research
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双相介质波动方程系数矩阵对称化及其SBP-SAT差分模拟
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作者 孙铖 刘泰玉 +2 位作者 蒋关希曦 张剑伟 杨在林 《振动与冲击》 北大核心 2025年第16期108-118,共11页
波动方程系数矩阵对称化是整合不同类别波动方程、降低波传播模拟难度的有效方法,目前已成功应用于声波方程、各向同性与各向异性介质弹性波动方程。该研究将推导出双项介质波动方程的系数矩阵对称式;随后,引入多轴完全匹配层,采用迎风... 波动方程系数矩阵对称化是整合不同类别波动方程、降低波传播模拟难度的有效方法,目前已成功应用于声波方程、各向同性与各向异性介质弹性波动方程。该研究将推导出双项介质波动方程的系数矩阵对称式;随后,引入多轴完全匹配层,采用迎风格式分部求和-一致逼近项(summation by parts-simultaneous approximation terms,SBP-SAT)有限差分方法离散波动方程,并通过能量法进行稳定性评估。通过数值仿真,表明所提出的离散框架具有整合度高,稳定性好和拓展性强等特点。此外,该方法可以稳定模拟曲线域中的波传播并降低其实现成本,表明了波动方程系数矩阵对称化方法及其离散框架在波传播模拟领域具有广泛的应用前景。 展开更多
关键词 双相介质波动方程 系数矩阵对称式 分部求和-一致逼近项(SBP-sat) 有限差分方法 能量法
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CLASS理论视域下师幼互动的关联逻辑、困境与创新路径 被引量:1
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作者 董玟鑫 《教育进展》 2025年第5期1398-1402,共5页
师幼互动质量不仅是幼儿园教育质量的关键要素,还是我国学前教育内涵式发展的重要方面。运用文献资料、逻辑分析等方法,从CLASS理论视域下探析师幼互动的关联逻辑、困境与创新路径。研究发现:CLASS理论与师幼互动的关联逻辑在于理论同... 师幼互动质量不仅是幼儿园教育质量的关键要素,还是我国学前教育内涵式发展的重要方面。运用文献资料、逻辑分析等方法,从CLASS理论视域下探析师幼互动的关联逻辑、困境与创新路径。研究发现:CLASS理论与师幼互动的关联逻辑在于理论同源性与实践契合性。CLASS视域下师幼互动面临情感支持的缺乏、课堂组织的失衡、教学支持的脱节的现实困境。基于此,提出情感交融,以情育情;协调秩序,灵活组织;回应需求,弥合引导的创新路径。The quality of teacher-child interaction is not only a key element of the quality of kindergarten education, but also an important aspect of the connotative development of pre-school education in China. Using literature, logical analysis and other methods, we analyze the associated logic, dilemma and innovative path of teacher-child interaction from the perspective of CLASS theory. The study found that the logic of CLASS theory and teacher-child interaction lies in the homology of the theory and the fit of practice, and that teacher-child interaction in the CLASS perspective faces the dilemmas of lack of emotional support, imbalance of classroom organization, and disconnection of pedagogical support. Based on this, we propose innovative paths of emotional integration, nurturing emotions with emotions, coordinating order, flexible organization, responding to needs, and bridging guidance. 展开更多
关键词 师幼互动 class理论 关联逻辑 现实困境 创新路径
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MALDI-TOF MS与TB-SAT联合检测在非结核分枝杆菌病诊断中的应用
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作者 任哲 冯建纯 +2 位作者 谢炯 田二朋 马伟立 《河北医学》 2025年第9期1563-1568,共6页
目的:探讨基体辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)与RNA恒温扩增实时荧光检测(TB-SAT)联合检测在非结核分枝杆菌(NTM)肺病诊断中的应用。方法:选取2020年1月至2024年12月河北省胸科医院收治的疑似152例NTM肺病患者,对支气管肺... 目的:探讨基体辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)与RNA恒温扩增实时荧光检测(TB-SAT)联合检测在非结核分枝杆菌(NTM)肺病诊断中的应用。方法:选取2020年1月至2024年12月河北省胸科医院收治的疑似152例NTM肺病患者,对支气管肺泡灌洗液(BALF)标本进行MALDI-TOF MS、TB-SAT检查,以NTM肺病诊断标准为金标准,分析MALDI-TOF MS、TB-SAT单一筛查NTM肺病的效能及与金标准的一致性,分析MALDI-TOF MS、TB-SAT联合诊断NTM肺病、NTM肺病菌种分布的效能。结果:以NTM肺病诊断标准为准,最终确诊80例(53.63%),其中46.51%胞内分枝杆菌为主;MALDI-TOF MS、TB-SAT检测NTM肺病阳性率81.25%、78.75%,2种检测技术与金标准的一致性Kappa值分别为0.533(95%CI:0.376~0.691)、0.538(95%CI:0.378~0.697);MALDI-TOF MS、TB-SAT联合诊断敏感性、特异性、准确性、阳性预测值、阴性预测值均高于单一筛查(P<0.05);MALDI-TOF MS、TB-SAT联合诊断NTM肺病菌种分布与金标准的一致性Kappa值为0.882(95%CI:0.757~1.007)。结论:MALDI-TOF MS、TB-SAT联合检测在NTM肺病中具有良好的诊断价值,可提高诊断准确性,为临床准确诊断NTM提供有力支持。 展开更多
关键词 MALDI-TOF MS TB-sat 非结核分枝杆菌病 诊断
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