The current various proposals at the International Maritime Organisation （IMO） for the s factor （probability of surviving a given flooding） make no reference to survival time. The paper shows a direct link of the ...The current various proposals at the International Maritime Organisation （IMO） for the s factor （probability of surviving a given flooding） make no reference to survival time. The paper shows a direct link of the ＂prime＂ s factor with the time to capsize and shows how to utilise experimental data from 30-minute test runs for the s factor based on longer duration of tests. Unexpectedly, the extension of tests has a modest effect on the survival factor, and hence-modest effect on subdivision index A. Much more important is improving a deficient formulation for the required index R, as flooding cases with si = 1 have an infinite survival time.展开更多
Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemo...Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent assay.In selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of phagocytosis.Results:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these results.Additionally,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by 4-hydroxynonenal.Conclusions:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator.展开更多
AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha...AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha(TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis(UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants(R702W, G908 R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype. Also, production of TNF-α was correlated to plasmatic levels of LPS Binding Protein(LBP), soluble(s) CD14 and to the activity state of the disease.RESULTS The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-αcompared with healthy subjects and UC patients, and after stimulation with Pam3CSK4(ligand of TLR2/1) and MDP-L18(ligand of NOD2) this difference was maintained, while other microbial stimuli(LPS, ligand of TLR4 and Poly I:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells. There was no significant difference in the production of TNF- α between patients who carried CD-associated heterozygous or homozygous variants in NOD2 and patients with wild type NOD2 genotype. Although serum LBP levels have been shown to correlate positively with the state of activity of the disease, TNF-α production did not show a clear correlation with either LBP or s CD14 levels in plasma. Moreover, no clear correlation was seen between TNF-α production and activity indices in either CD or UC.CONCLUSION Peripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of NOD2 genotype and without a clear correlation with disease activity.展开更多
研究了单个线性关系是可闭线性关系的充分必要条件;并对L0=(A B C D),其中A,B,C,D是相应Hilbert空间上的线性关系,利用C相对A的有界性与B相对D的有界性及A,D的可闭性,推出了L_(0)也是可闭线性关系;同时,对于有界线性算子S=(S_(1) S_(2) ...研究了单个线性关系是可闭线性关系的充分必要条件;并对L0=(A B C D),其中A,B,C,D是相应Hilbert空间上的线性关系,利用C相对A的有界性与B相对D的有界性及A,D的可闭性,推出了L_(0)也是可闭线性关系;同时,对于有界线性算子S=(S_(1) S_(2) S_(3) S_(4)),得到当满足一定条件时L_(0)-μS的Frobenius-Schur分解公式,并得到了当L_(0)可闭时L_(0)的表达式,最后研究了L_(0)的S-本质谱。展开更多
As one of the first coastal open cities in China,Yantai City is situated in the eastern Shandong Peninsula,bordered by the Yellow Sea and Bohai Sea.With the continuous improvement of tourism infrastructure,public enth...As one of the first coastal open cities in China,Yantai City is situated in the eastern Shandong Peninsula,bordered by the Yellow Sea and Bohai Sea.With the continuous improvement of tourism infrastructure,public enthusiasm for tourism in Yantai has been growing.To formulate more effective tourism development policies tailored to the local context,this study examines Yantai City using a multiple linear regression model to identify the primary factors influencing domestic tourism income.Based on the findings,this paper proposes scientifically grounded and actionable strategies to further optimize the development of tourism in Yantai City.展开更多
The large dynamic range and high performance of temperature and humidity profile lidar made it a popular tool for monitoring the atmospheric environment.In this study,we carried out an accurate analysis of the key com...The large dynamic range and high performance of temperature and humidity profile lidar made it a popular tool for monitoring the atmospheric environment.In this study,we carried out an accurate analysis of the key components of the lidar system,including lasers,the emitting and receiving light paths,and photodetectors.We combined the validation of simulations with experimental testing,and then the applicability indicators and necessary conditions in accordance were suggested.For the frequency stability of the laser,when the wavelength shift is less than 0.15%,the measurement accuracy of the system can be guaranteed to be less than 5%.The degree of near-field signal distortion will be significantly impacted by the size of the geometric factor’s transition zone.The introduced measurement error is less than 2%when the deviation angle of the emission axis is less than 0.1 mrad.It has been tested that selecting a low-sensitivity detector can help to improve the sensitivity of temperature detection since this channel is sensitive to the detector’s nonlinearity.To enhance lidar’s detection capabilities and direct the lidar system design process,it is beneficial to analyze the precision of the key components.展开更多
为更好地对S/X波段天气雷达组网融合在广西区域的应用能力进行评估,利用雷达观测资料,依次进行基数据解析、Z_(H)-K_(DP)综合法衰减订正、单站雷达网格化及多部雷达组网拼图,最终利用组合反射率、等高平面反射率对广西现有雷达组网覆盖...为更好地对S/X波段天气雷达组网融合在广西区域的应用能力进行评估,利用雷达观测资料,依次进行基数据解析、Z_(H)-K_(DP)综合法衰减订正、单站雷达网格化及多部雷达组网拼图,最终利用组合反射率、等高平面反射率对广西现有雷达组网覆盖能力在2023年第4号台风“泰利”影响过程进行初步应用分析。结果显示:结合径向廓线对比、网格化对比及多个连续体扫得到的反射率对比分析,经过Z_(H)-K_(DP)综合法订正后的X波段天气雷达反射率在一定范围内具有较高的可靠性;将组网拼图结果应用于台风“泰利”暴雨过程分析,对比S波段和S/X波段天气雷达组网后的0.5 km、0.75 km、1.0 km和2.0 km CAPPI(Constant Altitude Plan Position Indicator)组网反射率因子覆盖区域,结果显示X波段加入雷达组网后,得到了空间结构连续、覆盖更广的资料,有效补充了广西新一代天气雷达的低层盲区、阻挡空缺区等。展开更多
The γ-rays and protons from an Ed = 20 keV deuteron beam incident on a D-Ti target were measured. A branching ratio of the 2H（d,γ）^4He reaction versus the ^2H（d,p）^3H reaction of Гγ/Гp = （1.061 0.34） x 10.7...The γ-rays and protons from an Ed = 20 keV deuteron beam incident on a D-Ti target were measured. A branching ratio of the 2H（d,γ）^4He reaction versus the ^2H（d,p）^3H reaction of Гγ/Гp = （1.061 0.34） x 10.7 has been obtained, and the astrophysical S factor of the ^2H（d,γ）He reaction at the center of mass energy Ecm ≈ 7 keV of （6.0±2.4） ×10^6 keV.b was deduced.展开更多
The growth of the software game development industry is enormous and is gaining importance day by day. This growth imposes severe pressure and a number of issues and challenges on the game development community. Game ...The growth of the software game development industry is enormous and is gaining importance day by day. This growth imposes severe pressure and a number of issues and challenges on the game development community. Game development is a complex process, and one important game development choice is to consider the developer＇s perspective to produce good-quality software games by improving the game development process. The objective of this study is to provide a better understanding of the developer＇s dimension as a factor in software game success. It focuses mainly on an empirical investigation of the effect of key developer＇s factors on the software game development process and eventually on the quality of the resulting game. A quantitative survey was developed and conducted to identify key developer＇s factors for an enhanced game development process. For this study, the developed survey was used to test the research model and hypotheses. The results provide evidence that game development organizations must deal with multiple key factors to remain competitive and to handle high pressure in the software game industry. The main contribution of this paper is to investigate empirically the influence of key developer＇s factors on the game development process.展开更多
文摘The current various proposals at the International Maritime Organisation （IMO） for the s factor （probability of surviving a given flooding） make no reference to survival time. The paper shows a direct link of the ＂prime＂ s factor with the time to capsize and shows how to utilise experimental data from 30-minute test runs for the s factor based on longer duration of tests. Unexpectedly, the extension of tests has a modest effect on the survival factor, and hence-modest effect on subdivision index A. Much more important is improving a deficient formulation for the required index R, as flooding cases with si = 1 have an infinite survival time.
基金supported in the context of the Italian Malaria Network by grants from Compagnia di San Paolo-IMI and from Regione Piemonte,Ricerca Sanitaria Finalizzata 2008bis to PA
文摘Objective:To investigate whether the increase of tumor necrosis factor alpha is dependent on lipidic component of malarial pigment.Methods:Adherent human monocytes were fed for 3 hours with different meals(native hemozoin;lipid free hemozoin;and control latex particles),then tumor necrosis factor alpha was monitored in cell supernatants up to 48 hours through western blotting or specific enzyme-linked immunoadsorbent assay.In selected experiments,unfed monocytes were treated with different doses of 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid or 4-hydroxynonenal instead of phagocytosis.Results:Hemozoin-fed monocytes produced higher levels of tumor necrosis factor alpha than unstimulated and latex-fed cells, while lipid-free hemozoin did not reproduce these results.Additionally,hemozoin effects were mimicked dose-dependently by 15(S,R)-hydroxy-6,8,11,13-eicosatetraenoic acid,but not by 4-hydroxynonenal.Conclusions:Present data suggest an essential role for lipids in hemozoindependent enhanced release of tumor necrosis factor alpha from monocytes,and 15(S,R)hydroxy -6,8,11,13-eicosatetraenoic acid could be one possible specific mediator.
基金Supported by Institute for Maternal and Child Health,IRCCS"Burlo Garofolo",No.RC 03/2009
文摘AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial spreading.METHODS By means of flow cytometry, production of tumor necrosis factor-alpha(TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis(UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants(R702W, G908 R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype. Also, production of TNF-α was correlated to plasmatic levels of LPS Binding Protein(LBP), soluble(s) CD14 and to the activity state of the disease.RESULTS The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-αcompared with healthy subjects and UC patients, and after stimulation with Pam3CSK4(ligand of TLR2/1) and MDP-L18(ligand of NOD2) this difference was maintained, while other microbial stimuli(LPS, ligand of TLR4 and Poly I:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells. There was no significant difference in the production of TNF- α between patients who carried CD-associated heterozygous or homozygous variants in NOD2 and patients with wild type NOD2 genotype. Although serum LBP levels have been shown to correlate positively with the state of activity of the disease, TNF-α production did not show a clear correlation with either LBP or s CD14 levels in plasma. Moreover, no clear correlation was seen between TNF-α production and activity indices in either CD or UC.CONCLUSION Peripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of NOD2 genotype and without a clear correlation with disease activity.
文摘研究了单个线性关系是可闭线性关系的充分必要条件;并对L0=(A B C D),其中A,B,C,D是相应Hilbert空间上的线性关系,利用C相对A的有界性与B相对D的有界性及A,D的可闭性,推出了L_(0)也是可闭线性关系;同时,对于有界线性算子S=(S_(1) S_(2) S_(3) S_(4)),得到当满足一定条件时L_(0)-μS的Frobenius-Schur分解公式,并得到了当L_(0)可闭时L_(0)的表达式,最后研究了L_(0)的S-本质谱。
文摘As one of the first coastal open cities in China,Yantai City is situated in the eastern Shandong Peninsula,bordered by the Yellow Sea and Bohai Sea.With the continuous improvement of tourism infrastructure,public enthusiasm for tourism in Yantai has been growing.To formulate more effective tourism development policies tailored to the local context,this study examines Yantai City using a multiple linear regression model to identify the primary factors influencing domestic tourism income.Based on the findings,this paper proposes scientifically grounded and actionable strategies to further optimize the development of tourism in Yantai City.
基金supported by the National Key R&D Program of China(Nos.2022YFC3700400 and 2022YFC3704000).
文摘The large dynamic range and high performance of temperature and humidity profile lidar made it a popular tool for monitoring the atmospheric environment.In this study,we carried out an accurate analysis of the key components of the lidar system,including lasers,the emitting and receiving light paths,and photodetectors.We combined the validation of simulations with experimental testing,and then the applicability indicators and necessary conditions in accordance were suggested.For the frequency stability of the laser,when the wavelength shift is less than 0.15%,the measurement accuracy of the system can be guaranteed to be less than 5%.The degree of near-field signal distortion will be significantly impacted by the size of the geometric factor’s transition zone.The introduced measurement error is less than 2%when the deviation angle of the emission axis is less than 0.1 mrad.It has been tested that selecting a low-sensitivity detector can help to improve the sensitivity of temperature detection since this channel is sensitive to the detector’s nonlinearity.To enhance lidar’s detection capabilities and direct the lidar system design process,it is beneficial to analyze the precision of the key components.
文摘为更好地对S/X波段天气雷达组网融合在广西区域的应用能力进行评估,利用雷达观测资料,依次进行基数据解析、Z_(H)-K_(DP)综合法衰减订正、单站雷达网格化及多部雷达组网拼图,最终利用组合反射率、等高平面反射率对广西现有雷达组网覆盖能力在2023年第4号台风“泰利”影响过程进行初步应用分析。结果显示:结合径向廓线对比、网格化对比及多个连续体扫得到的反射率对比分析,经过Z_(H)-K_(DP)综合法订正后的X波段天气雷达反射率在一定范围内具有较高的可靠性;将组网拼图结果应用于台风“泰利”暴雨过程分析,对比S波段和S/X波段天气雷达组网后的0.5 km、0.75 km、1.0 km和2.0 km CAPPI(Constant Altitude Plan Position Indicator)组网反射率因子覆盖区域,结果显示X波段加入雷达组网后,得到了空间结构连续、覆盖更广的资料,有效补充了广西新一代天气雷达的低层盲区、阻挡空缺区等。
文摘The γ-rays and protons from an Ed = 20 keV deuteron beam incident on a D-Ti target were measured. A branching ratio of the 2H（d,γ）^4He reaction versus the ^2H（d,p）^3H reaction of Гγ/Гp = （1.061 0.34） x 10.7 has been obtained, and the astrophysical S factor of the ^2H（d,γ）He reaction at the center of mass energy Ecm ≈ 7 keV of （6.0±2.4） ×10^6 keV.b was deduced.
文摘The growth of the software game development industry is enormous and is gaining importance day by day. This growth imposes severe pressure and a number of issues and challenges on the game development community. Game development is a complex process, and one important game development choice is to consider the developer＇s perspective to produce good-quality software games by improving the game development process. The objective of this study is to provide a better understanding of the developer＇s dimension as a factor in software game success. It focuses mainly on an empirical investigation of the effect of key developer＇s factors on the software game development process and eventually on the quality of the resulting game. A quantitative survey was developed and conducted to identify key developer＇s factors for an enhanced game development process. For this study, the developed survey was used to test the research model and hypotheses. The results provide evidence that game development organizations must deal with multiple key factors to remain competitive and to handle high pressure in the software game industry. The main contribution of this paper is to investigate empirically the influence of key developer＇s factors on the game development process.
