The development of low-energy consumption and environmentally friendly electrodeposition of metal/alloy films or coatings is presently one of the primary topics for the research community.For this purpose,deep eutecti...The development of low-energy consumption and environmentally friendly electrodeposition of metal/alloy films or coatings is presently one of the primary topics for the research community.For this purpose,deep eutectic solvents(DESs)are valued as electrolytes for their advantages of low operating temperature and wide electrochemical windows.At present,there is large amount of literature on this emerging field,but there are no specialized reviews of these studies.Here,after a brief introduction of DESs’concept and history,we comprehensively reviewed the lastest progress on the metal/alloy electrodeposition in DESs.Additionally,we discussed the key influence factors of the electrodeposition process and analyzed the corresponding mechanisms.Based on these,we emphasized the importance of the establishment of predictive models for dealing with the challenges in large-scale applications.展开更多
Intratumoral bacteria have been proven to be widely exist in tumors,different tumors of different systems have different types of characteristic bacteria.Intratumoral bacteria will become a new and important biomarker...Intratumoral bacteria have been proven to be widely exist in tumors,different tumors of different systems have different types of characteristic bacteria.Intratumoral bacteria will become a new and important biomarker in the full cycle of tumor development.This article emphasizes the key role of intratumoral bacteria in the occurrence and progress of tumors,including promoting tumor development,accelerating tumor metastasis and promoting tumor cell resistance.In addition,this article also summarizes the application of intratumoral bacteria in tumor diagnosis and prognosis.Especially,this article outlines the treatment strategies of intratumoral bacteria,including non-nanodelivery therapy strategies and nanodelivery therapy strategies,such as antibiotic,macromolecular,inflammatory factor inhibitors,near-infrared-photothermal therapy,inorganic antibacterial agents,reactive species and microbes therapy,in these strategies,nano delivery system provides a promising treatment that solves the problem of drug resistance,reducing toxicity and improving patient compliance.This article is hoped to guide future research on intratumoral bacteria on tumors.展开更多
Laminated metal composites(LMCs)have widespread application prospects and are set to become indispensable in addressing modern engineering challenges owing to their capability of leveraging the synergy between differe...Laminated metal composites(LMCs)have widespread application prospects and are set to become indispensable in addressing modern engineering challenges owing to their capability of leveraging the synergy between different metals and tailoring performance by flexibly regulating the layered configuration.The plastic forming process,as a promising advanced manufacturing technology,has been increasingly adopted for the fabrication of LMC components due to its advantages of high material utilization rate,high production efficiency,and excellent mechanical properties of the product.This review delved into the research progress on the plastic-forming process of LMCs,including rolling,extrusion,spinning,etc.It outlined the forming principles,unique characteristics,bonding mechanisms,and the influence of key process parameters on deformation,microstructure,and property.This review focused on the heterogeneous deformation and interfacial regulation of LMCs,providing insights into the mechanisms of heterogeneous deformation,damage and fracture,and formation mechanisms of intermetallic compounds.It also delineated the experimental characterization and numerical modeling methods to elucidate the heterogeneous deformation behavior,as well as the approaches to evaluating and enhancing the performance of LMCs.Finally,the challenges and prospects of manufacturing high-performance LMCs by plastic forming process are orchestrated.展开更多
Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly ...Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.展开更多
On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyo...On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.展开更多
AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on diseas...AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.展开更多
Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge percep...Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.展开更多
Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory v...Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.展开更多
Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemot...Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.展开更多
Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By...Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.展开更多
The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and pro...The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.展开更多
Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the ten...Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.展开更多
This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the ...This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.展开更多
AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:...AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:Totally 716 eyes of 716 patients with primary open angle glaucoma(POAG)with at least 5 reliable 24-2 test results and 2y of follow-up were selected.The functional GEE model was used to detect perimetric progression in the training dataset(501 eyes).In the testing dataset(215 eyes),progression was evaluated the functional GEE model,mean deviation(MD)and visual field index(VFI)rates of change,Advanced Glaucoma Intervention Study(AGIS)and Collaborative Initial Glaucoma Treatment Study(CIGTS)scores,and pointwise linear regression(PLR).RESULTS:The proposed method showed the highest proportion of eyes detected as progression(54.4%),followed by the VFI rate(34.4%),PLR(23.3%),and MD rate(21.4%).The CIGTS and AGIS scores had a lower proportion of eyes detected as progression(7.9%and 5.1%,respectively).The time to detection of progression was significantly shorter for the proposed method than that of other algorithms(adjusted P≤0.019).The VFI rate displayed moderate pairwise agreement with the proposed method(k=0.47).CONCLUSION:The functional GEE model shows the highest proportion of eyes detected as perimetric progression and the shortest time to detect perimetric progression in patients with POAG.展开更多
Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functiona...Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functional interplay in PC remain unclear.This study aimed to define the role of S100A14 in PC progression.Methods:Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes.Prognostic relevance was assessed via Kaplan-Meier and ROC analyses.Functional experiments were performed in PANC-1 and BxPC-3 cells,including qRT-PCR,CCK-8 assay,Western blotting,Transwell assay,and apoptosis assay.Co-immunoprecipitation(Co-IP)was used to verify S100A14-S100A16 interaction.CHX chase and dual-luciferase assays were employed to assess protein stability and transcriptional activity.Results:S100A14 was markedly upregulated in PC tissues and cell lines and identified as a key prognostic gene.Silencing S100A14 suppressed EMT,proliferation,invasion,and migration,while reversing S100A16-mediated p53 inhibition and enhancing apoptosis.Mechanistically,Co-IP assay confirmed the protein interaction between S100A14 and S100A16;S100A14 stabilized S100A16 protein through post-translational modification without transcriptional regulation;the S100A14/S100A16 axis reduced p53 protein stability and inhibited its transcriptional activity as well as the downstream p21 expression.Critically,knockdown of S100A14 abrogated the pro-metastatic phenotype of cancer cells.Conclusion:This study identifies S100A14 promotes PC progression by stabilizing S100A16 and suppressing the tumor-suppressive p53/p21 pathway;knockdown of S100A14 can reverse the above effects,restore p53 function,and enhance cancer cell apoptosis.Targeting the S100A14/S100A16/p53 regulatory axis could represent a promising therapeutic approach for PC.展开更多
Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities...Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities,defense capabilities,and composite national strength all reached new heights.”declared President Xi Jinping in his 2026 New Year message on De-By CHINA TODAY cember 31,2025,offering a succinct summary of China’s development over the past year,marked by resilience,progress,and renewed confidence as the country stands at the threshold of a new development phase.展开更多
From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological p...From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological practice and lived rural experience.展开更多
The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a...The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.展开更多
Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 ...Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades.展开更多
With the emergence and development of wearable devices,the novel ene rgy storage systems with flexible feature and high energy density are urgently needed.As we all know,for next generation high energystorage systems,...With the emergence and development of wearable devices,the novel ene rgy storage systems with flexible feature and high energy density are urgently needed.As we all know,for next generation high energystorage systems,lithium-sulfur(Li-S) batteries with a high theoretical capacity are regarded as one of the most promising candidates.In addition,the flexible Li-S batteries have received more and more attention.The determined factor in the flexible Li-S batteries is how to design the foldable electrodes including both anode and cathode.As for the flexible sulfur cathode,it could be obtained by integrating the electroactive sulfur with a flexible substrate,generally.In recent years,the flexible cathode of Li-S batteries have made considerable progress,however there are also many huge challenges needing to overcome,such as low content of sulfur,fast decrease of capacity and short cycle life.In this paper,the current develop status of flexible cathodes of Li-S batteries have been summarized,and the future trend also be pointed out.展开更多
基金financially supported from the National Natural Science Foundation of China(Nos.52274291,52204305)Beijing Institute of Technology Research Fund Program for Young Scholars,China(No.1740011182102).
文摘The development of low-energy consumption and environmentally friendly electrodeposition of metal/alloy films or coatings is presently one of the primary topics for the research community.For this purpose,deep eutectic solvents(DESs)are valued as electrolytes for their advantages of low operating temperature and wide electrochemical windows.At present,there is large amount of literature on this emerging field,but there are no specialized reviews of these studies.Here,after a brief introduction of DESs’concept and history,we comprehensively reviewed the lastest progress on the metal/alloy electrodeposition in DESs.Additionally,we discussed the key influence factors of the electrodeposition process and analyzed the corresponding mechanisms.Based on these,we emphasized the importance of the establishment of predictive models for dealing with the challenges in large-scale applications.
基金supported by CAMS Innovation Fund for Medical Sciences(CIFMS),China(No.2021-I2M-1-026)。
文摘Intratumoral bacteria have been proven to be widely exist in tumors,different tumors of different systems have different types of characteristic bacteria.Intratumoral bacteria will become a new and important biomarker in the full cycle of tumor development.This article emphasizes the key role of intratumoral bacteria in the occurrence and progress of tumors,including promoting tumor development,accelerating tumor metastasis and promoting tumor cell resistance.In addition,this article also summarizes the application of intratumoral bacteria in tumor diagnosis and prognosis.Especially,this article outlines the treatment strategies of intratumoral bacteria,including non-nanodelivery therapy strategies and nanodelivery therapy strategies,such as antibiotic,macromolecular,inflammatory factor inhibitors,near-infrared-photothermal therapy,inorganic antibacterial agents,reactive species and microbes therapy,in these strategies,nano delivery system provides a promising treatment that solves the problem of drug resistance,reducing toxicity and improving patient compliance.This article is hoped to guide future research on intratumoral bacteria on tumors.
基金supported by the National Natural Science Foundation of China(Grant Nos.52305361,52105337,52475354,and 52090043)the BK21 Four program(SNU Materials Education/Research Division for Creative Global Leaders)+1 种基金the China Postdoctoral Science Foundation(Grant No.2023M741245),and the National Key Research and Development Program of China(Grant No.2022YFB3706903)support from the Ko-rean Ministry of Trade,Industry and Energy(MOTIE,Korea)(Grant No.20022438).
文摘Laminated metal composites(LMCs)have widespread application prospects and are set to become indispensable in addressing modern engineering challenges owing to their capability of leveraging the synergy between different metals and tailoring performance by flexibly regulating the layered configuration.The plastic forming process,as a promising advanced manufacturing technology,has been increasingly adopted for the fabrication of LMC components due to its advantages of high material utilization rate,high production efficiency,and excellent mechanical properties of the product.This review delved into the research progress on the plastic-forming process of LMCs,including rolling,extrusion,spinning,etc.It outlined the forming principles,unique characteristics,bonding mechanisms,and the influence of key process parameters on deformation,microstructure,and property.This review focused on the heterogeneous deformation and interfacial regulation of LMCs,providing insights into the mechanisms of heterogeneous deformation,damage and fracture,and formation mechanisms of intermetallic compounds.It also delineated the experimental characterization and numerical modeling methods to elucidate the heterogeneous deformation behavior,as well as the approaches to evaluating and enhancing the performance of LMCs.Finally,the challenges and prospects of manufacturing high-performance LMCs by plastic forming process are orchestrated.
文摘Far from being mere rhetoric or abstract theory,Chinese-style modernisation is a concrete reality best grasped through direct experience.Before arriving in China,my knowledge of Chinese modernisation was based mainly on reading,classroom education,and accounts from colleagues who had already travelled around the country.
文摘On November 28th,the 2025 China National Textile and Apparel Council Science and Technology Awards Ceremony was held in Beijing.The project"Key Technologies and Systems for Green and Intelligent Production of Lyocell Fibers,"in which Zhengzhou Textile Machinery Co.,Ltd.(ZFJ)participated,won the first prize for scientific and technological progress.
基金Supported by The Eye Hospital of Wenzhou Medical University(No.KYQD20220304)The Fifth Batch of Provincial Ten Thousand Personnel Program Outstanding Talents Funding(No.474092204)+1 种基金Innovative Talents and Teams(2024)-The Fifth Batch of Funding Funds for Scientific and Technological Innovation Leading Talents Under the Provincial Ten Thousand Personnel Program(No.4240924003G)The Key R&D Program of Zhejiang(No.2022C03112).
文摘AIM:To identify early biomarkers associated with glaucomatous visual field(VF)progression in patients with normal-tension glaucoma(NTG).METHODS:This study included patients were divided into two groups based on disease progression status.Tear samples were collected for proteomic analysis.Dataindependent acquisition(DIA)mass spectrometry combined with bioinformatic analyses was performed to identify and validate potential protein biomarkers for NTG progression.Additionally,differentially expressed proteins(DEPs)were evaluated using mediating effect models and receiver operating characteristic(ROC)curve analysis.RESULTS:A total of 19 patients(20 eyes)with NTG participated in this study,including 10 patients(4 males and 6 females;10 eyes)in the progression group with mean age of 67.70±9.03y and 10 patients(4 males and 6 females;10 eyes)in the non-progression group with mean age of 68.60±7.58y.A total of 158 significantly differentially expressed proteins were detected.UniProt database annotation identified 3 upregulated proteins and 12 downregulated proteins.Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis showed that these DEPs were mainly enriched in pathways such as oocyte meiosis.Gene Ontology(GO)enrichment analysis revealed functional clusters related to cellular processes.Weighted gene coexpression network analysis(WGCNA)indicated that the core proteins were primarily involved in the neurodegenerationmultiple diseases pathway and cellular processes.Mediating effect analysis identified PRDX4(L)as a potential protein biomarker.ROC curve analysis showed that GNAI1 had the largest area under the curve(AUC=0.889).CONCLUSION:This study identifies 15 differentially expressed proteins in the tear fluid of NTG patients,including PRDX4(L).PRDX4(L)plays a key role in oxidative stress.
基金funded by Qinghai University Postgraduate Research and Practice Innovation Program of Funder,grant number 2025-GMKY-42.
文摘Recent advances in deep learning have significantly improved image deblurring;however,existing approaches still suffer from limited global context modeling,inadequate detail restoration,and poor texture or edge perception,especially under complex dynamic blur.To address these challenges,we propose the Multi-Resolution Fusion Network(MRFNet),a blind multi-scale deblurring framework that integrates progressive residual connectivity for hierarchical feature fusion.The network employs a three-stage design:(1)TransformerBlocks capture long-range dependencies and reconstruct coarse global structures;(2)Nonlinear Activation Free Blocks(NAFBlocks)enhance local detail representation and mid-level feature fusion;and(3)an optimized residual subnetwork based on gated feature modulation refines texture and edge details for high-fidelity restoration.Extensive experiments demonstrate that MRFNet achieves superior performance compared to state-of-the-art methods.On GoPro,it attains 32.52 dB Peak Signal-to-Noise Ratio(PSNR)and 0.071 Learned Perceptual Image Patch Similarity(LPIPS),outperforming MIMOWNet(32.50 dB,0.075).On HIDE,it achieves 30.25 dB PSNR and 0.945 Structural Similarity Index Measure(SSIM),representing gains of+0.26 dB and+0.015 SSIM over MIMO-UNet(29.99 dB,0.930).On RealBlur-J,it reaches 28.82 dB PSNR and 0.872 SSIM,surpassing MIMO-UNet by+1.19 dB and+0.035 SSIM(27.63 dB,0.837).These results validate the effectiveness of the proposed progressive residual fusion and hybrid attention mechanisms in balancing global context understanding and local detail recovery for blind image deblurring.
文摘Active inflammation in“inactive”progressive multiple sclerosis:Traditionally,the distinction between relapsing-remitting multiple sclerosis and progressive multiple sclerosis(PMS)has been framed as an inflammatory versus degenerative dichotomy.This was based on a broad misconception regarding essentially all neurodegenerative conditions,depicting the degenerative process as passive and immune-independent occurring as a late byproduct of active inflammation in the central nervous system(CNS),which is(solely)systemically driven.
文摘Colorectal cancer remains one of the leading causes of morbidity and mortality worldwide.Despite notable advances in early detection and therapeutic strategies,the molecular mechanisms underlying tumor survival,chemotherapy resistance,and metastasis are not yet fully understood.MicroRNAs(miRNAs)have emerged as pivotal regulators of cancer development,as they modulate gene expression and orchestrate key signaling pathways.However,the epigenetic mechanisms that control miRNA expression and their downstream gene targets remain largely unclear.In this review,we highlight the critical role of the colorectal cancer microenvironment in influencing miRNA expression and discuss how this regulation contributes to tumorigenesis.A better understanding of these processes may lead to the identification of novel therapeutic targets and strategies to prevent recurrence.
文摘Objective:To systematically sort out the application forms and effects of digital health intervention technologies in oral health management,and provide references for the digital development of stomatology.Methods:By reviewing relevant domestic and foreign studies and clinical practices,this paper summarizes and analyzes the main application forms of digital health interventions,including digital health education,intelligent detection equipment,telemedicine platforms,oral health big data platforms,and school-hospital collaborative screening robots.Results:Studies have shown that digital health interventions can effectively improve the public’s oral health knowledge level,optimize personal health behaviors,enhance clinical diagnosis efficiency,reduce overall medical costs,and promote the innovation and upgrading of oral health management models.Conclusion:Digital health intervention represents an inevitable trend in the future development of stomatology.In the future,it is still necessary to improve data security and privacy protection,technology adaptability and popularity,as well as relevant policies and norms,to give full play to its potential value.
基金supported by the National Natural Science Foundation of China(Grant Nos.52225404 and 52404121)the Key Research and Development Program Projects of Xinjiang Uygur Autonomous Region(Grant No.2024B03017).
文摘The mining industry is frequently subjected to various disasters,one of the major concerns is water-related disasters,particularly seam floor water inrush.These disasters pose significant threats to the safety and production of deep coal mines.The primary reason for this is that the fracturing of the rock mass induces the formation of a fluid(water)with both kinetic and potential energy.In this paper,a novel water inrush mechanism for deep floor failure due to water hammer effects is proposed based on the Xingdong coal mine in China.The water hammer pressure within rock pore channels has a different impact on the surrounding rock,leading to the degradation of the rock mass channel through repeated conduction and instantaneous cutoff.To further investigate this phenomenon,a progressive corrosion fracture mechanics(PCFM)model induced by a water hammer is established.The results show that the water hammer pressure caused by instantaneous channel truncation increases with increasing water flow velocity.The chemical damage factor(i.e.,stress corrosion fracture)is also incorporated into the Dugdale-Barenblatt(D-B)model to analyze the factors influencing the PCFM.These findings indicate that the greater the degree of damage is,the more likely the concealed fault is to experience water inrush.Finally,methods for controlling water inrush caused by the water hammer effects of deep floors are proposed.The failure mechanisms of the water hammer and the PCFM provide theoretical and practical guidance for controlling water inrush from the deep floor.
基金supported by the Major Program of National Natural Science Foundation of China(Grant No.42090055)the National Key ScientificInstruments and Equipment Development Projects of China(Grant No.41827808)the National Nature Science Foundation of China(Grant No.42207216).
文摘Reservoir-induced landslides in China's Three Gorges Reservoir area are prone to tensile cracks due to the influenceof their own weight and fluctuationsin water levels.The presence of cracks indicates that the tensile stress in the area has exceeded the tensile strength of the soil,leading to local instability.To explore the impact of tensile failure behavior on the stability and failure modes of reservoir landslides,the Huangtupo Riverside Slump#1 is taken as a case study.By considering local tensile failure,potential tensile cracks are incorporated into the analysis via the limit equilibrium method and reliability theory.The reliability of landslides under different tensile failure scenarios is quantified.Strain-softening characteristics of the soil are combined to further analyze the failure transmission path of the landslide.Finally,these potential failure modes were validated through physical model tests.The results show that cracks developing at rear positions reduce the stability of the slope and increase the probability of instability.During the destruction process,retrogressive failures with multiple sliding surfaces are likely to occur.However,tensile failure at the forefront reduces the likelihood of an individual slide mass descending.Progressive failure results in both regular and skip transmission patterns.Additionally,cracks and water level changes can also lead to shifts in the positions of the most dangerous blocks.Therefore,in practical landslide analysis and prevention,it is necessary to consider local tensile damage and identify potential tensile crack locations in advance to optimize prevention measures and accurately evaluate landslide risk.
文摘This article systematically reviews the characteristics of gut microbiota dysbiosis in IBS-D and associated therapeutic modulation strategies.It elaborates on the biosynthetic and metabolic pathways of bile acids,the phenotypes of bile acid dysregulation in IBS-D patients,and the related pathogenic molecular mechanisms.A primary focus is placed on dissecting the interaction mechanisms between the gut microbiota and bile acids,specifically the regulatory role of the gut microbiota in bile acid transformation and the influence of bile acids on the structure of the gut microbiota.Based on current research evidence,this article proposes the gut microbiota-bile acid axis as a potential therapeutic target for IBS-D.It aims to provide theoretical insights and novel perspectives for exploring innovative treatment strategies for IBS-D and elucidating its pathogenesis.
基金Supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI),funded by the Ministry of Health&Welfare,Republic of Korea(No.HR20C0026)the National Research Foundation of Korea(NRF)(No.RS-2023-00247504)the Patient-Centered Clinical Research Coordinating Center,funded by the Ministry of Health&Welfare,Republic of Korea(No.HC19C0276).
文摘AIM:To build a functional generalized estimating equation(GEE)model to detect glaucomatous visual field progression and compare the performance of the proposed method with that of commonly employed algorithms.METHODS:Totally 716 eyes of 716 patients with primary open angle glaucoma(POAG)with at least 5 reliable 24-2 test results and 2y of follow-up were selected.The functional GEE model was used to detect perimetric progression in the training dataset(501 eyes).In the testing dataset(215 eyes),progression was evaluated the functional GEE model,mean deviation(MD)and visual field index(VFI)rates of change,Advanced Glaucoma Intervention Study(AGIS)and Collaborative Initial Glaucoma Treatment Study(CIGTS)scores,and pointwise linear regression(PLR).RESULTS:The proposed method showed the highest proportion of eyes detected as progression(54.4%),followed by the VFI rate(34.4%),PLR(23.3%),and MD rate(21.4%).The CIGTS and AGIS scores had a lower proportion of eyes detected as progression(7.9%and 5.1%,respectively).The time to detection of progression was significantly shorter for the proposed method than that of other algorithms(adjusted P≤0.019).The VFI rate displayed moderate pairwise agreement with the proposed method(k=0.47).CONCLUSION:The functional GEE model shows the highest proportion of eyes detected as perimetric progression and the shortest time to detect perimetric progression in patients with POAG.
基金supported by the Yunnan Province Liu Liang Expert Workstation(No.202305AF150148)Famous Doctor Projects of Yunnan Province(No.XDYC-MY-2022-0032)+1 种基金Yunnan Health Training Project of High Level Talents(No.L-2024029)Innovation Team Special Program of Yunnan(No.202505AS350004).
文摘Objectives:Pancreatic cancer(PC)is characterized by poor prognosis due to its limited treatment choices and delayed detection.S100A14 has been implicated in tumor progression,yet its regulatory hierarchy and functional interplay in PC remain unclear.This study aimed to define the role of S100A14 in PC progression.Methods:Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes.Prognostic relevance was assessed via Kaplan-Meier and ROC analyses.Functional experiments were performed in PANC-1 and BxPC-3 cells,including qRT-PCR,CCK-8 assay,Western blotting,Transwell assay,and apoptosis assay.Co-immunoprecipitation(Co-IP)was used to verify S100A14-S100A16 interaction.CHX chase and dual-luciferase assays were employed to assess protein stability and transcriptional activity.Results:S100A14 was markedly upregulated in PC tissues and cell lines and identified as a key prognostic gene.Silencing S100A14 suppressed EMT,proliferation,invasion,and migration,while reversing S100A16-mediated p53 inhibition and enhancing apoptosis.Mechanistically,Co-IP assay confirmed the protein interaction between S100A14 and S100A16;S100A14 stabilized S100A16 protein through post-translational modification without transcriptional regulation;the S100A14/S100A16 axis reduced p53 protein stability and inhibited its transcriptional activity as well as the downstream p21 expression.Critically,knockdown of S100A14 abrogated the pro-metastatic phenotype of cancer cells.Conclusion:This study identifies S100A14 promotes PC progression by stabilizing S100A16 and suppressing the tumor-suppressive p53/p21 pathway;knockdown of S100A14 can reverse the above effects,restore p53 function,and enhance cancer cell apoptosis.Targeting the S100A14/S100A16/p53 regulatory axis could represent a promising therapeutic approach for PC.
文摘Chinese President Xi Jinping’s New Year message summarized an important year of steady progress as the country prepares to launch its 15th Five-Year Plan.“Our economic strength,scientific and technological abilities,defense capabilities,and composite national strength all reached new heights.”declared President Xi Jinping in his 2026 New Year message on De-By CHINA TODAY cember 31,2025,offering a succinct summary of China’s development over the past year,marked by resilience,progress,and renewed confidence as the country stands at the threshold of a new development phase.
文摘From lecture halls in Beijing to villages in the mountains of southwest China,a group of young rural innovators from Global South countries recently embarked on a journey that connected policy thinking,technological practice and lived rural experience.
基金supported by the National Key Research and Development Program of China (2021YFB1507401)Qinghai Province Clean Energy Minerals Special Project(2022013004qj004)Geological Survey Project of China Geological Survey (DD20221676, DD20230019)。
文摘The available heat content (stored heat energy) of hot dry rock (HDR) at a depth of 1–10 km in the global land crust is estimated to be 5.06×10~8 EJ,attracting considerable global attention.This paper presents a comprehensive analysis of the geological framework,HDR resource potential,exploration advancements,and the development of enhanced geothermal systems (EGSs) in China.HDR resources are extensively distributed across China.Within the depth range of 3–10 km,China’s estimated potential approximates2.29×10~7 EJ,with a theoretical power generation capacity of approximately 1.67×10^(16) k Wh.Replacing coal power with HDR can help to achieve a net emission reduction of 1.34×10^(16) kg CO_(2) (approximately1.34×10^(13) t),representing an emission reduction efficiency of 94.4%.Based on a development cycle of100 years,the average annual emission reduction reaches 1.34×10^(10) t CO_(2),equivalent to 117%of China’s annual carbon emissions in 2022.Furthermore,in the context of global warming,the development and utilization of HDR,which is feasible in virtually any region worldwide,offers significant potential to support global carbon reduction efforts.China has made substantial progress in HDR exploration in recent years.This paper systematically classifies China’s HDR resources into four genetic types—highly radioactive heat-producing,sedimentary basin,active volcanic,and intensely tectonic zones—and offers detailed exploration insights for each category.Each classification exhibits distinct geological and tectonic characteristics that influence heat source mechanisms and resource distribution.Furthermore,this paper documents significant advances in EGS construction,particularly in the Gonghe Basin on the northeastern margin of the Qianghai-Xizang Plateau and the Matouying uplift in the North China Basin,where successful reservoir stimulation,microseismic monitoring,and experimental power generation have been achieved.Despite these developments,challenges persist,including technical adaptability under complex geological conditions and the economic viability of large-scale HDR development.This paper suggests that future initiatives should emphasize resource exploration,technological research,and policy support to foster sustainable HDR resource development in China,thereby contributing to the global energy transition and environmental sustainability.
基金funded by the National Natural Science Foundation of China(Grant No.91844000)。
文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades.
基金This work was financially supported by the National Natural Science Foundation of China(No.51771076)the Innovative Research Groups of the National Natural Science Foundation of China(No.NSFC51621001)+2 种基金the“1000 plan”from Chinese Governmentthe Guangdong“Pearl River Talents Plan”(No.2017GC010218)the Guangzhou Science and Technology Plan Projects(No.201804010104)。
文摘With the emergence and development of wearable devices,the novel ene rgy storage systems with flexible feature and high energy density are urgently needed.As we all know,for next generation high energystorage systems,lithium-sulfur(Li-S) batteries with a high theoretical capacity are regarded as one of the most promising candidates.In addition,the flexible Li-S batteries have received more and more attention.The determined factor in the flexible Li-S batteries is how to design the foldable electrodes including both anode and cathode.As for the flexible sulfur cathode,it could be obtained by integrating the electroactive sulfur with a flexible substrate,generally.In recent years,the flexible cathode of Li-S batteries have made considerable progress,however there are also many huge challenges needing to overcome,such as low content of sulfur,fast decrease of capacity and short cycle life.In this paper,the current develop status of flexible cathodes of Li-S batteries have been summarized,and the future trend also be pointed out.
