Frequency hopping(FH)communication has good anti-fading,anti-jamming and anti-eavesdropping capabilities,so it is one of the main ways to combat electronic jamming.In order to further improve the anti-jamming capabili...Frequency hopping(FH)communication has good anti-fading,anti-jamming and anti-eavesdropping capabilities,so it is one of the main ways to combat electronic jamming.In order to further improve the anti-jamming capability of FH communication,the parameters such as fixed frequency interval,hopping rate and hopping frequency in conventional FH can be assigned with time-varying characteristics.In order to set appropriate hopping parameters to improve the performance of the system in the electromagnetic environment with various types of jamming,a heuristically accelerated Q-learning(HAQL)method is proposed in this paper.Firstly,a theoretical model for the parameter decision-making of FH system is made,and the key parameters affecting the energy efficiency of the system are analyzed.Secondly,a Q-learning model in complex electromagnetic environment is proposed,which includes setting states,actions and rewards,as well as a HAQL-based decisionmaking algorithm is put forward.Lastly,simulations are carried out under different jamming environments,and simulation results show that the average energy efficiency of HAQL algorithm is higher than that of the SARSA algorithm,the e-greedy QL algorithm and the HQL-OSGM algorithm,respectively.展开更多
Aircraft assembly is characterized by stringent precedence constraints,limited resource availability,spatial restrictions,and a high degree of manual intervention.These factors lead to considerable variability in oper...Aircraft assembly is characterized by stringent precedence constraints,limited resource availability,spatial restrictions,and a high degree of manual intervention.These factors lead to considerable variability in operator workloads and significantly increase the complexity of scheduling.To address this challenge,this study investigates the Aircraft Pulsating Assembly Line Scheduling Problem(APALSP)under skilled operator allocation,with the objective of minimizing assembly completion time.A mathematical model considering skilled operator allocation is developed,and a Q-Learning improved Particle Swarm Optimization algorithm(QLPSO)is proposed.In the algorithm design,a reverse scheduling strategy is adopted to effectively manage large-scale precedence constraints.Moreover,a reverse sequence encoding method is introduced to generate operation sequences,while a time decoding mechanism is employed to determine completion times.The problem is further reformulated as a Markov Decision Process(MDP)with explicitly defined state and action spaces.Within QLPSO,the Q-learning mechanism adaptively adjusts inertia weights and learning factors,thereby achieving a balance between exploration capability and convergence performance.To validate the effectiveness of the proposed approach,extensive computational experiments are conducted on benchmark instances of different scales,including small,medium,large,and ultra-large cases.The results demonstrate that QLPSO consistently delivers stable and high-quality solutions across all scenarios.In ultra-large-scale instances,it improves the best solution by 25.2%compared with the Genetic Algorithm(GA)and enhances the average solution by 16.9%over the Q-learning algorithm,showing clear advantages over the comparative methods.These findings not only confirm the effectiveness of the proposed algorithm but also provide valuable theoretical references and practical guidance for the intelligent scheduling optimization of aircraft pulsating assembly lines.展开更多
The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combi...The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combines numerical simulation with machine learning techniques to explore this issue.It presents a summary of special-shaped tunnel geometries and introduces a shape coefficient.Through the finite element software,Plaxis3D,the study simulates six key parameters—shape coefficient,burial depth ratio,tunnel’s longest horizontal length,internal friction angle,cohesion,and soil submerged bulk density—that impact uplift resistance across different conditions.Employing XGBoost and ANN methods,the feature importance of each parameter was analyzed based on the numerical simulation results.The findings demonstrate that a tunnel shape more closely resembling a circle leads to reduced uplift resistance in the overlying soil,whereas other parameters exhibit the contrary effects.Furthermore,the study reveals a diminishing trend in the feature importance of buried depth ratio,internal friction angle,tunnel longest horizontal length,cohesion,soil submerged bulk density,and shape coefficient in influencing uplift resistance.展开更多
Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model versi...Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model version 6 with a machine-learning-integrated four-mode version of the Modal Aerosol Module, we quantify global BC aging responses to emission reductions for 2011–2018 and for 2050 and 2100 under carbon neutrality. During 2011–18, global trends in BC aging degree(mass ratio of coatings to BC, R_(BC)) exhibited marked regional disparities, with a significant increase in China(5.4% yr^(-1)), which contrasts with minimal changes in the USA, Europe, and India. The divergence is attributed to opposing trends in secondary organic aerosol(SOA) and sulfate coatings, driven by regional changes in the emission ratios of corresponding coating precursors to BC(volatile organic compounds-VOCs/BC and SO_(2)/BC). Projections under carbon neutrality reveal that R_(BC) will increase globally by 47%(118%) in 2050(2100), with strong convergent increases expected across major source regions. The R_(BC) increase, primarily driven by enhanced SOA coatings due to sharper BC reductions relative to VOCs, will enhance the global BC mass absorption cross-section(MAC) by 11%(17%) in 2050(2100).Consequently, although the global BC burden will decline sharply by 60%(76%), the enhanced MAC partially offsets the magnitude of the decline in the BC direct radiative effect, resulting in the moderation of global BC DRE decreases to 88%(92%) of the BC burden reductions in 2050(2100). This study highlights the globally enhanced BC aging and light absorption capacity under carbon neutrality, thereby partly offsetting the impact of BC direct emission reductions on future changes in BC radiative effects globally.展开更多
Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalize...Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalized Learning Ecosystem,which integrates 3D/VR environments,as well as machine learning algorithms,and business intelligence frameworks to enhance learner-centered education and inferenced decision-making.This Learning System makes use of immersive,analytically assessed virtual learning spaces,therefore facilitating real-time monitoring of not just learning performance,but also overall engagement and behavioral patterns,via a comprehensive set of sustainability-oriented ESG-aligned Key Performance Indicators(KPIs).Machine learning models support predictive analysis,personalized feedback,and hybrid recommendation mechanisms,whilst dedicated dashboards translate complex educational data into actionable insights for all Use Cases of the System(Educational Institutions,Educators and Learners).Additionally,the presented Learning System introduces a structured Mentoring and Consulting Subsystem,thence reinforcing human-centered guidance alongside automated intelligence.The Platform’s modular architecture and simulation-centered evaluation approach actively support personalized,and continuously optimized learning pathways.Thence,it exemplifies a mature,adaptive Learning Ecosystem,supporting immersive technologies,analytics,and pedagogical support,hence,contributing to contemporary digital learning innovation and sociotechnical transformation in education.展开更多
As urbanization continues to accelerate,the challenges associated with managing transportation in metropolitan areas become increasingly complex.The surge in population density contributes to traffic congestion,impact...As urbanization continues to accelerate,the challenges associated with managing transportation in metropolitan areas become increasingly complex.The surge in population density contributes to traffic congestion,impacting travel experiences and posing safety risks.Smart urban transportation management emerges as a strategic solution,conceptualized here as a multidimensional big data problem.The success of this strategy hinges on the effective collection of information from diverse,extensive,and heterogeneous data sources,necessitating the implementation of full⁃stack Information and Communication Technology(ICT)solutions.The main idea of the work is to investigate the current technologies of Intelligent Transportation Systems(ITS)and enhance the safety of urban transportation systems.Machine learning models,trained on historical data,can predict traffic congestion,allowing for the implementation of preventive measures.Deep learning architectures,with their ability to handle complex data representations,further refine traffic predictions,contributing to more accurate and dynamic transportation management.The background of this research underscores the challenges posed by traffic congestion in metropolitan areas and emphasizes the need for advanced technological solutions.By integrating GPS and GIS technologies with machine learning algorithms,this work aims to pay attention to the development of intelligent transportation systems that not only address current challenges but also pave the way for future advancements in urban transportation management.展开更多
To integrate traditional culture and modern technology,Shandong University’s School of Software has promoted an interdisciplinary teaching project called IYAN&ITAN,the I Ching Knowledge Graph.The project,driven b...To integrate traditional culture and modern technology,Shandong University’s School of Software has promoted an interdisciplinary teaching project called IYAN&ITAN,the I Ching Knowledge Graph.The project,driven by I Ching texts,guides students to practice natural language processing(NLP)and knowledge graph technology in a task-oriented curriculum,based on constructivism,situated learning,and inquiry-based pedagogy,with a progressive and task-oriented teaching model.The platform established enables the retrieval of knowledge,parsing of text,symbolic-numeric analysis,and historical commentary integration,making possible multidimensional,structured representation of I Ching knowledge,and offering an extensible reference for interdisciplinary learning in the context of New Engineering Education.展开更多
BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning ofte...BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.展开更多
In the rapidly evolving landscape of digital transformation and industrial integration,higher education faces the challenge of cultivating applied talents equipped with interdisciplinary knowledge,engineering skills,a...In the rapidly evolving landscape of digital transformation and industrial integration,higher education faces the challenge of cultivating applied talents equipped with interdisciplinary knowledge,engineering skills,and innovative thinking.Traditional teaching models often fail to bridge the gap between theoretical knowledge and practical application,resulting in passive learning and limited problem-solving capabilities.This paper proposes a three-dimensional integrated teaching model centered on“Information Technology-Domain Knowledge-Outcome Production”(the“2+2+2”credit framework)to address these challenges.Drawing on constructivist theories,Bloom’s Taxonomy,and the CDIO model,the framework uses real projects to drive learning,facilitating the seamless integration of theoretical teaching and practical innovation.The model emphasizes tiered teaching objectives and interdisciplinary pathways,supported by dynamic assessment systems that track students’growth in knowledge,skills,and abilities.Applied in smart health and financial technology domains,this approach enhances students’comprehensive capabilities,aligning educational outcomes with industry demands.This study offers replicable strategies for educational reform in new engineering disciplines,aiming to transform students into proactive innovators and versatile talents.展开更多
针对无监督环境下传统网络异常诊断算法存在异常点定位和异常数据分类准确率低等不足,通过设计一种基于改进Q-learning算法的无线网络异常诊断方法:首先基于ADU(Asynchronous Data Unit异步数据单元)单元采集无线网络的数据流,并提取数...针对无监督环境下传统网络异常诊断算法存在异常点定位和异常数据分类准确率低等不足,通过设计一种基于改进Q-learning算法的无线网络异常诊断方法:首先基于ADU(Asynchronous Data Unit异步数据单元)单元采集无线网络的数据流,并提取数据包特征;然后构建Q-learning算法模型探索状态值和奖励值的平衡点,利用SA(Simulated Annealing模拟退火)算法从全局视角对下一时刻状态进行精确识别;最后确定训练样本的联合分布概率,提升输出值的逼近性能以达到平衡探索与代价之间的均衡。测试结果显示:改进Q-learning算法的网络异常定位准确率均值达99.4%,在不同类型网络异常的分类精度和分类效率等方面,也优于三种传统网络异常诊断方法。展开更多
This study aimed to integrate Monte Carlo(MC)simulation with deep learning(DL)-based denoising techniques to achieve fast and accurate prediction of high-quality electronic portal imaging device(EPID)transmission dose...This study aimed to integrate Monte Carlo(MC)simulation with deep learning(DL)-based denoising techniques to achieve fast and accurate prediction of high-quality electronic portal imaging device(EPID)transmission dose(TD)for patientspecific quality assurance(PSQA).A total of 100 lung cases were used to obtain the noisy EPID TD by the ARCHER MC code under four kinds of particle numbers(1×10^(6),1×10^(7),1×10^(8)and 1×10^(9)),and the original EPID TD was denoised by the SUNet neural network.The denoised EPID TD was assessed both qualitatively and quantitatively using the structural similarity(SSIM),peak signal-to-noise ratio(PSNR),and gamma passing rate(GPR)with respect to 1×10^(9)as a reference.The computation times for both the MC simulation and DL-based denoising were recorded.As the number of particles increased,both the quality of the noisy EPID TD and computation time increased significantly(1×10^(6):1.12 s,1×10^(7):1.72 s,1×10^(8):8.62 s,and 1×10^(9):73.89 s).In contrast,the DL-based denoising time remained at 0.13-0.16 s.The denoised EPID TD shows a smoother visual appearance and profile curves,but differences between 1×10^(6)and 1×10^(9)still remain.SSIM improves from 0.61 to 0.95 for 1×10^(6),0.70 to 0.96 for 1×10^(7),and 0.90 to 0.97 for 1×10^(8).PSNR increases by>20%for 1×10^(6)and 1×10^(7),and>10%for 1×10^(8).GPR improves from 48.47%to 89.10%for 1×10^(6),61.04%to 94.35%for 1×10^(7),and 91.88%to 99.55%for 1×10^(8).The method that combines MC simulation with DL-based denoising for EPID TD generation can accelerate TD prediction and maintain high accuracy,offering a promising solution for efficient PSQA.展开更多
基金State Key Program of National Natural Science of China under grant nos.U19B2016。
文摘Frequency hopping(FH)communication has good anti-fading,anti-jamming and anti-eavesdropping capabilities,so it is one of the main ways to combat electronic jamming.In order to further improve the anti-jamming capability of FH communication,the parameters such as fixed frequency interval,hopping rate and hopping frequency in conventional FH can be assigned with time-varying characteristics.In order to set appropriate hopping parameters to improve the performance of the system in the electromagnetic environment with various types of jamming,a heuristically accelerated Q-learning(HAQL)method is proposed in this paper.Firstly,a theoretical model for the parameter decision-making of FH system is made,and the key parameters affecting the energy efficiency of the system are analyzed.Secondly,a Q-learning model in complex electromagnetic environment is proposed,which includes setting states,actions and rewards,as well as a HAQL-based decisionmaking algorithm is put forward.Lastly,simulations are carried out under different jamming environments,and simulation results show that the average energy efficiency of HAQL algorithm is higher than that of the SARSA algorithm,the e-greedy QL algorithm and the HQL-OSGM algorithm,respectively.
基金supported by the National Natural Science Foundation of China(Grant No.52475543)Natural Science Foundation of Henan(Grant No.252300421101)+1 种基金Henan Province University Science and Technology Innovation Talent Support Plan(Grant No.24HASTIT048)Science and Technology Innovation Team Project of Zhengzhou University of Light Industry(Grant No.23XNKJTD0101).
文摘Aircraft assembly is characterized by stringent precedence constraints,limited resource availability,spatial restrictions,and a high degree of manual intervention.These factors lead to considerable variability in operator workloads and significantly increase the complexity of scheduling.To address this challenge,this study investigates the Aircraft Pulsating Assembly Line Scheduling Problem(APALSP)under skilled operator allocation,with the objective of minimizing assembly completion time.A mathematical model considering skilled operator allocation is developed,and a Q-Learning improved Particle Swarm Optimization algorithm(QLPSO)is proposed.In the algorithm design,a reverse scheduling strategy is adopted to effectively manage large-scale precedence constraints.Moreover,a reverse sequence encoding method is introduced to generate operation sequences,while a time decoding mechanism is employed to determine completion times.The problem is further reformulated as a Markov Decision Process(MDP)with explicitly defined state and action spaces.Within QLPSO,the Q-learning mechanism adaptively adjusts inertia weights and learning factors,thereby achieving a balance between exploration capability and convergence performance.To validate the effectiveness of the proposed approach,extensive computational experiments are conducted on benchmark instances of different scales,including small,medium,large,and ultra-large cases.The results demonstrate that QLPSO consistently delivers stable and high-quality solutions across all scenarios.In ultra-large-scale instances,it improves the best solution by 25.2%compared with the Genetic Algorithm(GA)and enhances the average solution by 16.9%over the Q-learning algorithm,showing clear advantages over the comparative methods.These findings not only confirm the effectiveness of the proposed algorithm but also provide valuable theoretical references and practical guidance for the intelligent scheduling optimization of aircraft pulsating assembly lines.
基金Guangzhou Metro Scientific Research Project(No.JT204-100111-23001)Chongqing Municipal Special Project for Technological Innovation and Application Development(No.CSTB2022TIAD-KPX0101)Science and Technology Research and Development Program of China State Railway Group Co.,Ltd.(No.N2023G045)。
文摘The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combines numerical simulation with machine learning techniques to explore this issue.It presents a summary of special-shaped tunnel geometries and introduces a shape coefficient.Through the finite element software,Plaxis3D,the study simulates six key parameters—shape coefficient,burial depth ratio,tunnel’s longest horizontal length,internal friction angle,cohesion,and soil submerged bulk density—that impact uplift resistance across different conditions.Employing XGBoost and ANN methods,the feature importance of each parameter was analyzed based on the numerical simulation results.The findings demonstrate that a tunnel shape more closely resembling a circle leads to reduced uplift resistance in the overlying soil,whereas other parameters exhibit the contrary effects.Furthermore,the study reveals a diminishing trend in the feature importance of buried depth ratio,internal friction angle,tunnel longest horizontal length,cohesion,soil submerged bulk density,and shape coefficient in influencing uplift resistance.
基金supported by the National Natural Science Foundation of China (42505149,41925023,U2342223,42105069,and 91744208)the China Postdoctoral Science Foundation (2025M770303)+1 种基金the Fundamental Research Funds for the Central Universities (14380230)the Jiangsu Funding Program for Excellent Postdoctoral Talent,and Jiangsu Collaborative Innovation Center of Climate Change。
文摘Countries around the world have been making efforts to reduce pollutant emissions. However, the response of global black carbon(BC) aging to emission changes remains unclear. Using the Community Atmosphere Model version 6 with a machine-learning-integrated four-mode version of the Modal Aerosol Module, we quantify global BC aging responses to emission reductions for 2011–2018 and for 2050 and 2100 under carbon neutrality. During 2011–18, global trends in BC aging degree(mass ratio of coatings to BC, R_(BC)) exhibited marked regional disparities, with a significant increase in China(5.4% yr^(-1)), which contrasts with minimal changes in the USA, Europe, and India. The divergence is attributed to opposing trends in secondary organic aerosol(SOA) and sulfate coatings, driven by regional changes in the emission ratios of corresponding coating precursors to BC(volatile organic compounds-VOCs/BC and SO_(2)/BC). Projections under carbon neutrality reveal that R_(BC) will increase globally by 47%(118%) in 2050(2100), with strong convergent increases expected across major source regions. The R_(BC) increase, primarily driven by enhanced SOA coatings due to sharper BC reductions relative to VOCs, will enhance the global BC mass absorption cross-section(MAC) by 11%(17%) in 2050(2100).Consequently, although the global BC burden will decline sharply by 60%(76%), the enhanced MAC partially offsets the magnitude of the decline in the BC direct radiative effect, resulting in the moderation of global BC DRE decreases to 88%(92%) of the BC burden reductions in 2050(2100). This study highlights the globally enhanced BC aging and light absorption capacity under carbon neutrality, thereby partly offsetting the impact of BC direct emission reductions on future changes in BC radiative effects globally.
文摘Latest digital advancements have intensified the necessity for adaptive,data-driven and socially-centered learning ecosystems.This paper presents the formulation of a cross-platform,innovative,gamified and personalized Learning Ecosystem,which integrates 3D/VR environments,as well as machine learning algorithms,and business intelligence frameworks to enhance learner-centered education and inferenced decision-making.This Learning System makes use of immersive,analytically assessed virtual learning spaces,therefore facilitating real-time monitoring of not just learning performance,but also overall engagement and behavioral patterns,via a comprehensive set of sustainability-oriented ESG-aligned Key Performance Indicators(KPIs).Machine learning models support predictive analysis,personalized feedback,and hybrid recommendation mechanisms,whilst dedicated dashboards translate complex educational data into actionable insights for all Use Cases of the System(Educational Institutions,Educators and Learners).Additionally,the presented Learning System introduces a structured Mentoring and Consulting Subsystem,thence reinforcing human-centered guidance alongside automated intelligence.The Platform’s modular architecture and simulation-centered evaluation approach actively support personalized,and continuously optimized learning pathways.Thence,it exemplifies a mature,adaptive Learning Ecosystem,supporting immersive technologies,analytics,and pedagogical support,hence,contributing to contemporary digital learning innovation and sociotechnical transformation in education.
文摘As urbanization continues to accelerate,the challenges associated with managing transportation in metropolitan areas become increasingly complex.The surge in population density contributes to traffic congestion,impacting travel experiences and posing safety risks.Smart urban transportation management emerges as a strategic solution,conceptualized here as a multidimensional big data problem.The success of this strategy hinges on the effective collection of information from diverse,extensive,and heterogeneous data sources,necessitating the implementation of full⁃stack Information and Communication Technology(ICT)solutions.The main idea of the work is to investigate the current technologies of Intelligent Transportation Systems(ITS)and enhance the safety of urban transportation systems.Machine learning models,trained on historical data,can predict traffic congestion,allowing for the implementation of preventive measures.Deep learning architectures,with their ability to handle complex data representations,further refine traffic predictions,contributing to more accurate and dynamic transportation management.The background of this research underscores the challenges posed by traffic congestion in metropolitan areas and emphasizes the need for advanced technological solutions.By integrating GPS and GIS technologies with machine learning algorithms,this work aims to pay attention to the development of intelligent transportation systems that not only address current challenges but also pave the way for future advancements in urban transportation management.
基金support provided by the Shandong University Education and Teaching Reform Research Project(2024Y232)the“New 20 Regulations for Universities”funding program of Jinan(202228089).
文摘To integrate traditional culture and modern technology,Shandong University’s School of Software has promoted an interdisciplinary teaching project called IYAN&ITAN,the I Ching Knowledge Graph.The project,driven by I Ching texts,guides students to practice natural language processing(NLP)and knowledge graph technology in a task-oriented curriculum,based on constructivism,situated learning,and inquiry-based pedagogy,with a progressive and task-oriented teaching model.The platform established enables the retrieval of knowledge,parsing of text,symbolic-numeric analysis,and historical commentary integration,making possible multidimensional,structured representation of I Ching knowledge,and offering an extensible reference for interdisciplinary learning in the context of New Engineering Education.
基金Supported by Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau),No.2023MSXM060.
文摘BACKGROUND The accurate prediction of lymph node metastasis(LNM)is crucial for managing locally advanced(T3/T4)colorectal cancer(CRC).However,both traditional histopathology and standard slide-level deep learning often fail to capture the sparse and diagnostically critical features of metastatic potential.AIM To develop and validate a case-level multiple-instance learning(MIL)framework mimicking a pathologist's comprehensive review and improve T3/T4 CRC LNM prediction.METHODS The whole-slide images of 130 patients with T3/T4 CRC were retrospectively collected.A case-level MIL framework utilising the CONCH v1.5 and UNI2-h deep learning models was trained on features from all haematoxylin and eosinstained primary tumour slides for each patient.These pathological features were subsequently integrated with clinical data,and model performance was evaluated using the area under the curve(AUC).RESULTS The case-level framework demonstrated superior LNM prediction over slide-level training,with the CONCH v1.5 model achieving a mean AUC(±SD)of 0.899±0.033 vs 0.814±0.083,respectively.Integrating pathology features with clinical data further enhanced performance,yielding a top model with a mean AUC of 0.904±0.047,in sharp contrast to a clinical-only model(mean AUC 0.584±0.084).Crucially,a pathologist’s review confirmed that the model-identified high-attention regions correspond to known high-risk histopathological features.CONCLUSION A case-level MIL framework provides a superior approach for predicting LNM in advanced CRC.This method shows promise for risk stratification and therapy decisions,requiring further validation.
文摘In the rapidly evolving landscape of digital transformation and industrial integration,higher education faces the challenge of cultivating applied talents equipped with interdisciplinary knowledge,engineering skills,and innovative thinking.Traditional teaching models often fail to bridge the gap between theoretical knowledge and practical application,resulting in passive learning and limited problem-solving capabilities.This paper proposes a three-dimensional integrated teaching model centered on“Information Technology-Domain Knowledge-Outcome Production”(the“2+2+2”credit framework)to address these challenges.Drawing on constructivist theories,Bloom’s Taxonomy,and the CDIO model,the framework uses real projects to drive learning,facilitating the seamless integration of theoretical teaching and practical innovation.The model emphasizes tiered teaching objectives and interdisciplinary pathways,supported by dynamic assessment systems that track students’growth in knowledge,skills,and abilities.Applied in smart health and financial technology domains,this approach enhances students’comprehensive capabilities,aligning educational outcomes with industry demands.This study offers replicable strategies for educational reform in new engineering disciplines,aiming to transform students into proactive innovators and versatile talents.
文摘针对无监督环境下传统网络异常诊断算法存在异常点定位和异常数据分类准确率低等不足,通过设计一种基于改进Q-learning算法的无线网络异常诊断方法:首先基于ADU(Asynchronous Data Unit异步数据单元)单元采集无线网络的数据流,并提取数据包特征;然后构建Q-learning算法模型探索状态值和奖励值的平衡点,利用SA(Simulated Annealing模拟退火)算法从全局视角对下一时刻状态进行精确识别;最后确定训练样本的联合分布概率,提升输出值的逼近性能以达到平衡探索与代价之间的均衡。测试结果显示:改进Q-learning算法的网络异常定位准确率均值达99.4%,在不同类型网络异常的分类精度和分类效率等方面,也优于三种传统网络异常诊断方法。
基金supported by National Key R&D Program of China(No.2022YFC2404604)Chongqing Research Institution Performance Incentive Guidance Special Project(No.CSTB2023JXJL-YFX0080)Chongqing Medical Scientific Research Project(Joint project of Chongqing Health Commission and Science and Technology Bureau)(No.2022DBXM005)。
文摘This study aimed to integrate Monte Carlo(MC)simulation with deep learning(DL)-based denoising techniques to achieve fast and accurate prediction of high-quality electronic portal imaging device(EPID)transmission dose(TD)for patientspecific quality assurance(PSQA).A total of 100 lung cases were used to obtain the noisy EPID TD by the ARCHER MC code under four kinds of particle numbers(1×10^(6),1×10^(7),1×10^(8)and 1×10^(9)),and the original EPID TD was denoised by the SUNet neural network.The denoised EPID TD was assessed both qualitatively and quantitatively using the structural similarity(SSIM),peak signal-to-noise ratio(PSNR),and gamma passing rate(GPR)with respect to 1×10^(9)as a reference.The computation times for both the MC simulation and DL-based denoising were recorded.As the number of particles increased,both the quality of the noisy EPID TD and computation time increased significantly(1×10^(6):1.12 s,1×10^(7):1.72 s,1×10^(8):8.62 s,and 1×10^(9):73.89 s).In contrast,the DL-based denoising time remained at 0.13-0.16 s.The denoised EPID TD shows a smoother visual appearance and profile curves,but differences between 1×10^(6)and 1×10^(9)still remain.SSIM improves from 0.61 to 0.95 for 1×10^(6),0.70 to 0.96 for 1×10^(7),and 0.90 to 0.97 for 1×10^(8).PSNR increases by>20%for 1×10^(6)and 1×10^(7),and>10%for 1×10^(8).GPR improves from 48.47%to 89.10%for 1×10^(6),61.04%to 94.35%for 1×10^(7),and 91.88%to 99.55%for 1×10^(8).The method that combines MC simulation with DL-based denoising for EPID TD generation can accelerate TD prediction and maintain high accuracy,offering a promising solution for efficient PSQA.
