There are major concerns over both the security of energy supplies （declining supplies and political control） and the en- vironmental costs associated with energy generation and use. The global consumption of carbon...There are major concerns over both the security of energy supplies （declining supplies and political control） and the en- vironmental costs associated with energy generation and use. The global consumption of carbon-containing fossil fuels for heat, electricity, transport and the manufacture of chemicals is not sustainable. This has promulgated a great interest in various forms of renewable energy and the imposition,展开更多
Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenn...Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.展开更多
BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gas...BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.展开更多
Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institut...Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.展开更多
Since the beginning of the 21st century,advances in big data and artificial intelligence have driven a paradigm shift in the geosciences,moving the field from qualitative descriptions toward quantitative analysis,from...Since the beginning of the 21st century,advances in big data and artificial intelligence have driven a paradigm shift in the geosciences,moving the field from qualitative descriptions toward quantitative analysis,from observing phenomena to uncovering underlying mechanisms,from regional-scale investigations to global perspectives,and from experience-based inference toward data-and model-enabled intelligent prediction.AlphaEarth Foundations(AEF)is a next-generation geospatial intelligence platform that addresses these changes by introducing a unified 64-dimensional shared embedding space,enabling-for the first time-standardized representation and seamless integration of 12 distinct types of Earth observation data,including optical,radar,and lidar.This framework significantly improves data assimilation efficiency and resolves the persistent problem of“data silos”in geoscience research.AEF is helping redefine research methodologies and fostering breakthroughs,particularly in quantitative Earth system science.This paper systematically examines how AEF’s innovative architecture-featuring multi-source data fusion,high-dimensional feature representation learning,and a scalable computational framework-facilitates intelligent,precise,and realtime data-driven geoscientific research.Using case studies from resource and environmental applications,we demonstrate AEF’s broad potential and identify emerging innovation needs.Our findings show that AEF not only enhances the efficiency of solving traditional geoscientific problems but also stimulates novel research directions and methodological approaches.展开更多
The Langrial iron ore deposits,located in the villages of Dubran and Darkot in Hazara,Pakistan,were evaluated using remote sensing,magnetic,and geochemical investigations.Data from ASTER,Landsat-8,and Sentinel-2 satel...The Langrial iron ore deposits,located in the villages of Dubran and Darkot in Hazara,Pakistan,were evaluated using remote sensing,magnetic,and geochemical investigations.Data from ASTER,Landsat-8,and Sentinel-2 satellites were utilized and processed through techniques such as band ratio analysis,band compositing,and NDVI masking to reduce vegetation effects and to delineate various lithological units and mineralogical signatures within the study area.Magnetic anomalies revealed multiple levels of iron mineralization,with the hematite zone showing the most significant potential for high-grade iron ore.Geochemical analyses confirmed the presence of iron,along with minerals such as chromium,calcium,magnesium,and lead.In Dubran,mean iron concentrations are recorded at 370.94 mg/kg,whereas in Darkot,they reach up to 2052 mg/kg.The integration of remote sensing,magnetic,and geochemical data delineates key mineralized zones in the various parts of the study area.This research highlights the importance of combining geophysical and geochemical methodologies to refine mineral exploration efforts.The findings enhance our understanding of the Langrial iron ore deposits and highlight their economic potential for sustainable mining practices.This study will contribute to meeting the growing demand for iron ore resources and reducing Pakistan's reliance on imports,thereby promoting the sustainable development of local industries.展开更多
BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related co...BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma creation.METHODS Patients with stoma was prospectively recorded in the established stoma system.Data was collected from this stoma management system from November 2021 through May 2024.The rates of stoma-related complications were assessed,and potential risk factors were analyzed using univariate and multivariate logistic regression models.RESULTS A total of 734 patients were included in the analysis.The results showed that 12.3%of patients experienced stoma-related complications,with mucocutaneous separation,edema,and skin excoriation being the most common complications.The majority(90%)of complications were classified as grade 2 according to the Clavien-Dindo classification.Surgical factors,such as blood loss volume greater than 500 mL and open surgery,were significantly associated with stoma complications.Additionally,stoma features like location,shape,color,height,and edema were important factors in the association with complications.Body mass index over 30 kg/m²was also found to be a significant risk factor.CONCLUSION These findings highlight the need for a holistic approach to preventing and managing stoma complications,considering both patient-related and surgical factors.展开更多
Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the co...Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the continuous increase in the cost of LIBs.Along with the rapid development of electric transportation,it has become inevitable to trigger a new round of competition in alternative energy storage systems.Some monovalent rechargeable metal ion batteries(sodium ion batteries(SIBs)and potassium ion batteries(PIBs),etc.)and multi-valent rechargeable metal-ion batteries(magnesium ion batteries(MIBs),calcium ion batteries(CIBs),zinc ion batteries(ZIBs),and aluminum ion batteries(AIBs),etc.)are potential candidates,which can replace LIBs in some of the scenarios to alleviate the pressure on supply.The cathode material plays a crucial role in determining the battery capacity.Transition metal compounds dominated by layered transition metal oxides as key cathode materials for secondary batteries play an important role in the advancement of various battery energy storage systems.In summary,this manuscript aims to review and summarize the research progress on transition metal compounds used as cathodes in different metal ion batteries,with the aim of providing valuable guidance for the exploration and design of high-performance integrated battery systems.展开更多
Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation ar...Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation are necessary.Although great progress has been achieved in H-storage by using high-pressure cylinder up to 70 MPa.展开更多
As an old Chinese saying goes,knowledge changes fate.An ordinary college student carries expectations of several generations of his or her family.Consequently,a vast majority of high school graduates applying for coll...As an old Chinese saying goes,knowledge changes fate.An ordinary college student carries expectations of several generations of his or her family.Consequently,a vast majority of high school graduates applying for college prefer to choose colleges and majors with good employment prospects.Two years ago,facing hundreds of majors,I was caught in a dilemma.Law seemed appealing,as it could offer a high income and a worry-free life.展开更多
Force feedback bilateral teleoperation represents a pivotal advancement in control technology,finding widespread application in hazardous material transportation,perilous environments,space and deep-sea exploration,an...Force feedback bilateral teleoperation represents a pivotal advancement in control technology,finding widespread application in hazardous material transportation,perilous environments,space and deep-sea exploration,and healthcare domains.This paper traces the evolutionary trajectory of force feedback bilateral teleoperation from its conceptual inception to its current complexity.It elucidates the fundamental principles underpinning interaction forces and tactile exchanges,with a specific emphasis on the crucial role of tactile devices.In this review,a quantitative analysis of force feedback bilateral teleoperation development trends from 2011 to 2024 has been conducted,utilizing published journal article data as the primary source of information.The review accentuates classical control frameworks and algorithms,while also delving into existing research advancements and prospec-tive breakthrough directions.Moreover,it explores specific practical scenarios ranging from intricate surgeries to hazardous environment exploration,underscoring the technology’s potential to revolutionize industries by augmenting human manipulation of remote systems.This underscores the pivotal role of force feedback bilateral teleoperation as a transformative human-machine interface,capable of shaping flexible control strategies and addressing technological bottlenecks.Future research endeavors in force feedback bilateral teleoperation are expected to prioritize the creation of more immersive experiences,overcoming technical hurdles,fortifying human-machine collaboration,and broadening application domains,particularly within the realms of medical intervention and hazardous environments.With the continuous progression of technology,the integration of human intelligence and robotic capabilities is expected to produce more innovations and breakthroughs in the field of automatic control.展开更多
BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health impact.Precise fore...BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health impact.Precise forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this malignancy.AIM To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric carcinoma.METHODS Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and 2020.Least absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient outcomes.The model's predictability and discriminative ability were evaluated via receiver operating characteristic curves.To evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were performed.RESULTS A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte ratio.The area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,respectively.The AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,respectively.The model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding 0.75.Compared with TNM staging,the model demonstrated superior clinical utility.Ultimately,a nomogram was developed via a web-based interface.CONCLUSION This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrated strong predictive ability.Based on these findings,this model can aid clinicians in implementing personalized interventions for patients with gastric cancer.展开更多
The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helpi...The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.展开更多
Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospe...Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.展开更多
China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the ma...China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the market surged from 11.4 billion yuan in 2018 to 22.9 billion yuan in 2023,achieving a compound annual growth rate(CAGR) of 15%.With projections estimating a rise to 44 billion yuan by 2028 at a 14% CAGR,the sector's long-term growth prospects remain strong.展开更多
Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primaril...Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.展开更多
The Polar Regions host one of the harshest and most unique ecosystems on Earth,harboring a diverse array of micro-and macro-organisms.These inhabitants showcase remarkable taxonomic and genetic originality,presenting ...The Polar Regions host one of the harshest and most unique ecosystems on Earth,harboring a diverse array of micro-and macro-organisms.These inhabitants showcase remarkable taxonomic and genetic originality,presenting unparalleled opportunities for bioprospecting,alongside demonstrating extraordinary adaptation mechanisms for survival.展开更多
Vietnam's manufacturing and processing companies areop timistic about business prospects in the second quarter(Q2)of this year,according to a recent survey by the National Statis-tics Office(Gso).The results of th...Vietnam's manufacturing and processing companies areop timistic about business prospects in the second quarter(Q2)of this year,according to a recent survey by the National Statis-tics Office(Gso).The results of the survey indicate that 45.8%of bustnesses anticipate improved business performance in Q22025 compared to Ql while 39.2%expect stability and l5%foresee encountering more difficulties ahead.展开更多
In recent years,magnesium(Mg)alloys and magnesium matrix composites(MMCs)have made significant progress in the application of advanced equipment,lightweighting and biomedical engineering.Additive manufacturing(AM),wit...In recent years,magnesium(Mg)alloys and magnesium matrix composites(MMCs)have made significant progress in the application of advanced equipment,lightweighting and biomedical engineering.Additive manufacturing(AM),with high flexibility and design freedom,is of great significance for the rapid prototyping of high-performance Mg alloy components with complex structures.Due to the layerby-layer deposition characteristics of additive manufactured Mg alloys and MMCs,the components exhibit distinct microstructures and properties compared to those manufactured via traditional technologies.AM technology for Mg alloys and MMCs still faces challenges in practical applications,including raw materials,processing conditions,post-processing,and selection of process parameters.This paper presents an overview of recent progress in Mg alloys and MMCs fabricated using various AM technologies,including wire-arc directed energy deposition(WA-DED),laser powder bed fusion(LPBF)and solid-state additive manufacturing(SSAM).The relationships between process parameters,forming quality,microstructure and properties are systematically discussed.In particular,the influence of manufacturing processes and material composition on corrosion behavior and biocompatibility is investigated.Additionally,mechanisms and applications of field-assisted additive manufacturing and post-treatment in defect suppression,microstructure evolution,and performance improvement in Mg alloys and MMCs are summarized.Finally,the potential applications of AM Mg alloys and MMCs are prospected,and future development trends are proposed.展开更多
文摘There are major concerns over both the security of energy supplies （declining supplies and political control） and the en- vironmental costs associated with energy generation and use. The global consumption of carbon-containing fossil fuels for heat, electricity, transport and the manufacture of chemicals is not sustainable. This has promulgated a great interest in various forms of renewable energy and the imposition,
基金supported by the High-level Talents Introduction Plan from Central South University(No.502045003)the National Natural Science Foundation of China(No.42277438)Hunan Provincial Natural Science Foundation for Distinguished Young Scholars(No.2024JJ2082)to Fang Xiao,and the Postgraduate Independent Exploration and Innovation Project of Central South University,China(Nos.2024ZZTS0557 and 2023ZZTS0993)。
文摘Existing evidence suggests residential greenness is beneficial to human,while no research to date explored the associations of greenness with age-related macular degeneration(AMD).To evaluate the association of greenness with AMD,modification and mediation effect of air pollution,we conducted this prospective study.We con-structed weighted quantile sum(WQS)index as co-exposure to nitrogen oxides(NO_(x)),particulate matter<2.5μm(PM_(2.5)),particulate matter<10μm(PM10).Stratified Cox regression models were applied to test the effect of exposure.Effect modification of air pollution was assessed.Stratified Cox models through the indirect method and Aalen additive risk models were used in mediation analysis.Over median follow-up of 11.67 years,4596 AMD events were ascertained.Hazard ratios(HRs)and 95%confidence intervals(95%CIs)of incident AMD for pollution per interquartile range(IQR)increment were 1.10(1.04–1.16)for nitrogen dioxide(NO_(2)),1.09(1.03–1.15)for NO_(x),1.14(1.05–1.24)for PM_(2.5),1.13(1.05–1.21)for PM10.The HR(95%CI)of AMD associated with greenness 1000 m buffer per IQR increment was 0.91(0.86–0.97),300 m buffer was 0.94(0.89–0.99).The as-sociation between greenness 1000 m and AMD was 28.59%,44.77%,35.59%,32.31%and 27.08%mediated by the decreased WQS index,NO_(2),NO_(x),PM_(2.5) and PM10,respectively.Increased greenness was associated with lower AMD incidence,and air pollution partly mediate it,which implies that interventions aimed at improving air quality and increasing greenness could have a dual benefit in mitigating AMD risk.
基金the Research Project of the Chinese Digestive Early Cancer Physicians’Joint Growth Program,No.GTCZ-2021-AH-34-0012.
文摘BACKGROUND Gastric cancer is one of the most common cancers worldwide,especially in East Asia.AIM To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia(LGIN)in the gastric mucosa and provide valuable guidance for improving treatment efficacy.METHODS A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included.Among them,296 patients were followed up with endoscopic and biopsy pathology.Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.RESULTS The distribution sites of LGIN among the 357 patients were as follows:Gastric antrum(54.6%),gastric cardia(24.1%),gastric angulus(8.7%),gastric body(4.8%),gastric fundus(4.8%),and multiple sites(3.1%).Additionally,of the 357 patients with LGIN,112(31.4%)developed ulceration and 59(16.5%)experienced gastric polyps.Furthermore,231 of the 357(64.71%)patients with LGIN tested positive for Helicobacter pylori(H.pylori)infection.The H.pylori infection rates of the patients with LGIN with accompanying atrophy,intestinal metaplasia,and gastric ulcer were 51.95%,59.31%,and 28.57%,respectively.Multivariate logistic regression analysis showed that age≥60 years[odds ratio(OR)=3.063,95%confidence interval(CI):1.351-6.945,P=0.007],H.pylori infection(OR=3.560,95%CI:1.158-10.949,P=0.027),multiple locations(OR=10.136,95%CI:2.045-50.237,P=0.005),lesion size≥2 cm(OR=3.921,95%CI:1.664-9.237,P=0.002),and gastric ulcer(OR=2.730,95%CI:1.197-6.223,P=0.017)were predictive factors for LGIN progression.CONCLUSION LGIN progression is closely related to age,H.pylori positivity,multiple locations,lesion size≥2 cm,and gastric ulcer.Thus,actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.
文摘Purpose–This study summarizes the overall situation of the resources of the national science and technology innovation platform in the railway industry,including the distribution of platform types,supporting institutions,construction sites,professional fields,etc.,to provide a reference for the further improvement and optimization of the national science and technology innovation platform system in the railway industry.Design/methodology/approach–Through literature review,field investigation,expert consultation and other methods,this paper systematically investigates and analyzes the development status of the national science and technology innovation platform in the railway industry.Findings–Taking the national science and technology innovation platform of the railway industry as the research object,this paper investigates and analyzes the construction,development and distribution of the national science and technology innovation platform of railway industry over the years.And the National Engineering Research Center of High-speed Railway and Urban Rail Transit System Technology was taken as an example to introduce its operation effect.Originality/value–China Railway has made great development achievements,with the construction and development of national science and technology innovation platform in the railway industry.In recent years,a large number of national science and technology innovation platforms have been built in the railway industry,which play an important role in railway technological innovation,standard setting and commodification,and Railway Sciences provide strong support for railway technology development.
基金National Natural Science Foundation of China Key Project(No.42050103)Higher Education Disciplinary Innovation Program(No.B25052)+2 种基金the Guangdong Pearl River Talent Program Innovative and Entrepreneurial Team Project(No.2021ZT09H399)the Ministry of Education’s Frontiers Science Center for Deep-Time Digital Earth(DDE)(No.2652023001)Geological Survey Project of China Geological Survey(DD20240206201)。
文摘Since the beginning of the 21st century,advances in big data and artificial intelligence have driven a paradigm shift in the geosciences,moving the field from qualitative descriptions toward quantitative analysis,from observing phenomena to uncovering underlying mechanisms,from regional-scale investigations to global perspectives,and from experience-based inference toward data-and model-enabled intelligent prediction.AlphaEarth Foundations(AEF)is a next-generation geospatial intelligence platform that addresses these changes by introducing a unified 64-dimensional shared embedding space,enabling-for the first time-standardized representation and seamless integration of 12 distinct types of Earth observation data,including optical,radar,and lidar.This framework significantly improves data assimilation efficiency and resolves the persistent problem of“data silos”in geoscience research.AEF is helping redefine research methodologies and fostering breakthroughs,particularly in quantitative Earth system science.This paper systematically examines how AEF’s innovative architecture-featuring multi-source data fusion,high-dimensional feature representation learning,and a scalable computational framework-facilitates intelligent,precise,and realtime data-driven geoscientific research.Using case studies from resource and environmental applications,we demonstrate AEF’s broad potential and identify emerging innovation needs.Our findings show that AEF not only enhances the efficiency of solving traditional geoscientific problems but also stimulates novel research directions and methodological approaches.
文摘The Langrial iron ore deposits,located in the villages of Dubran and Darkot in Hazara,Pakistan,were evaluated using remote sensing,magnetic,and geochemical investigations.Data from ASTER,Landsat-8,and Sentinel-2 satellites were utilized and processed through techniques such as band ratio analysis,band compositing,and NDVI masking to reduce vegetation effects and to delineate various lithological units and mineralogical signatures within the study area.Magnetic anomalies revealed multiple levels of iron mineralization,with the hematite zone showing the most significant potential for high-grade iron ore.Geochemical analyses confirmed the presence of iron,along with minerals such as chromium,calcium,magnesium,and lead.In Dubran,mean iron concentrations are recorded at 370.94 mg/kg,whereas in Darkot,they reach up to 2052 mg/kg.The integration of remote sensing,magnetic,and geochemical data delineates key mineralized zones in the various parts of the study area.This research highlights the importance of combining geophysical and geochemical methodologies to refine mineral exploration efforts.The findings enhance our understanding of the Langrial iron ore deposits and highlight their economic potential for sustainable mining practices.This study will contribute to meeting the growing demand for iron ore resources and reducing Pakistan's reliance on imports,thereby promoting the sustainable development of local industries.
基金Beijing Municipal Administration of Hospitals Incubating Program,No.PZ20200272018 Beijing Talent Incubating Funding,No.2018-4+3 种基金National Natural Science Foundation of China,No.81773214Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support,No.ZYLX202116the National Key R&D Program of China,No.2021YFF1201104Science Foundation of Peking University Cancer Hospital-2023,No.JC202310.
文摘BACKGROUND Stoma creation is a common procedure in colorectal cancer surgery,however,stoma-related complications remain a significant concern.AIM To investigate the incidence,types,and risk factors of stoma-related complications in colorectal cancer patients who underwent stoma creation.METHODS Patients with stoma was prospectively recorded in the established stoma system.Data was collected from this stoma management system from November 2021 through May 2024.The rates of stoma-related complications were assessed,and potential risk factors were analyzed using univariate and multivariate logistic regression models.RESULTS A total of 734 patients were included in the analysis.The results showed that 12.3%of patients experienced stoma-related complications,with mucocutaneous separation,edema,and skin excoriation being the most common complications.The majority(90%)of complications were classified as grade 2 according to the Clavien-Dindo classification.Surgical factors,such as blood loss volume greater than 500 mL and open surgery,were significantly associated with stoma complications.Additionally,stoma features like location,shape,color,height,and edema were important factors in the association with complications.Body mass index over 30 kg/m²was also found to be a significant risk factor.CONCLUSION These findings highlight the need for a holistic approach to preventing and managing stoma complications,considering both patient-related and surgical factors.
基金support from the Nuclear Fuel Pellet Appearance Quality Inspection Device Project(20190304 A).
文摘Thefield of energy storage devices is primarily dominated by lithium-ion batteries(LIBs)due to their mature manufacturing processes and stable performance.However,immature lithium recovery technology cannot stop the continuous increase in the cost of LIBs.Along with the rapid development of electric transportation,it has become inevitable to trigger a new round of competition in alternative energy storage systems.Some monovalent rechargeable metal ion batteries(sodium ion batteries(SIBs)and potassium ion batteries(PIBs),etc.)and multi-valent rechargeable metal-ion batteries(magnesium ion batteries(MIBs),calcium ion batteries(CIBs),zinc ion batteries(ZIBs),and aluminum ion batteries(AIBs),etc.)are potential candidates,which can replace LIBs in some of the scenarios to alleviate the pressure on supply.The cathode material plays a crucial role in determining the battery capacity.Transition metal compounds dominated by layered transition metal oxides as key cathode materials for secondary batteries play an important role in the advancement of various battery energy storage systems.In summary,this manuscript aims to review and summarize the research progress on transition metal compounds used as cathodes in different metal ion batteries,with the aim of providing valuable guidance for the exploration and design of high-performance integrated battery systems.
文摘Hydrogen energy has long been considered an ideal green energy,and in particular,developed with great enthusiasm in recent years[1].To utilize hydrogen energy,efficient hydrogen storage(H-storage)and transportation are necessary.Although great progress has been achieved in H-storage by using high-pressure cylinder up to 70 MPa.
文摘As an old Chinese saying goes,knowledge changes fate.An ordinary college student carries expectations of several generations of his or her family.Consequently,a vast majority of high school graduates applying for college prefer to choose colleges and majors with good employment prospects.Two years ago,facing hundreds of majors,I was caught in a dilemma.Law seemed appealing,as it could offer a high income and a worry-free life.
基金supported by the MSIT(Ministry of Science and ICT),Republic of Korea,under the Convergence Security Core Talent Training Business Support Program(IITP-2024-RS-2024-00423071)supervised by the IITP(Institute of Information&Communications Technology Planning&Evaluation)supported by Sichuan Science and Technology Program(2023YFSY0026,2023YFH0004).
文摘Force feedback bilateral teleoperation represents a pivotal advancement in control technology,finding widespread application in hazardous material transportation,perilous environments,space and deep-sea exploration,and healthcare domains.This paper traces the evolutionary trajectory of force feedback bilateral teleoperation from its conceptual inception to its current complexity.It elucidates the fundamental principles underpinning interaction forces and tactile exchanges,with a specific emphasis on the crucial role of tactile devices.In this review,a quantitative analysis of force feedback bilateral teleoperation development trends from 2011 to 2024 has been conducted,utilizing published journal article data as the primary source of information.The review accentuates classical control frameworks and algorithms,while also delving into existing research advancements and prospec-tive breakthrough directions.Moreover,it explores specific practical scenarios ranging from intricate surgeries to hazardous environment exploration,underscoring the technology’s potential to revolutionize industries by augmenting human manipulation of remote systems.This underscores the pivotal role of force feedback bilateral teleoperation as a transformative human-machine interface,capable of shaping flexible control strategies and addressing technological bottlenecks.Future research endeavors in force feedback bilateral teleoperation are expected to prioritize the creation of more immersive experiences,overcoming technical hurdles,fortifying human-machine collaboration,and broadening application domains,particularly within the realms of medical intervention and hazardous environments.With the continuous progression of technology,the integration of human intelligence and robotic capabilities is expected to produce more innovations and breakthroughs in the field of automatic control.
文摘BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health impact.Precise forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this malignancy.AIM To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric carcinoma.METHODS Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and 2020.Least absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient outcomes.The model's predictability and discriminative ability were evaluated via receiver operating characteristic curves.To evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were performed.RESULTS A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte ratio.The area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,respectively.The AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,respectively.The model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding 0.75.Compared with TNM staging,the model demonstrated superior clinical utility.Ultimately,a nomogram was developed via a web-based interface.CONCLUSION This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrated strong predictive ability.Based on these findings,this model can aid clinicians in implementing personalized interventions for patients with gastric cancer.
文摘The tourism industry is one of the largest and fastest-growing sectors in the global market.It contributes towards complete growth and development of a country by bringing numerous economic value and benefit and helping in building country’s brand value,image and identity.Eritrea has huge tourism potential owing to its natural,historical and cultural endowments.However,the tourism industry in Eritrea is only in its nascent stage.This study,therefore,try to identify and examine the major challenges of sustainable tourism development and its prospects.Primary data were collected from interview with different Ministry of Tourism authorities,travel agencies and tour operators’managers and owners.Secondary data were retrieved from annual reports of international tourism organizations,Ministry of Tourism,the State of Eritrea and other documented sources including magazines and relevant research and papers.The research concludes that Eritrea has great potential for the development of tourism.However,the tourism growth is blocked by specific factors such as poor image,inadequate tourism infrastructural and technological facilities,absence of coordination among tourism stakeholders and lack of skilled man power.This study will assist policymakers to understand the present challenges of the tourism industry and provide necessary recommendations to adopt appropriate strategies and mechanisms.
基金supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)[grant number 2021-I2M-1-037]the National Natural Science Foundation of China[grant numbers 82373647,and 82473697].
文摘Objective This study aimed to explore the association between body mass index(BMI)and mortality based on the 10-year population-based multicenter prospective study.Methods A general population-based multicenter prospective study was conducted at four sites in rural China between 2013 and 2023.Multivariate Cox proportional hazards models and restricted cubic spline analyses were used to assess the association between BMI and mortality.Stratified analyses were performed based on the individual characteristics of the participants.Results Overall,19,107 participants with a sum of 163,095 person-years were included and 1,910 participants died.The underweight(<18.5 kg/m^(2))presented an increase in all-cause mortality(adjusted hazards ratio[aHR]=2.00,95%confidence interval[CI]:1.66–2.41),while overweight(≥24.0 to<28.0 kg/m^(2))and obesity(≥28.0 kg/m^(2))presented a decrease with an aHR of 0.61(95%CI:0.52–0.73)and 0.51(95%CI:0.37–0.70),respectively.Overweight(aHR=0.76,95%CI:0.67–0.86)and mild obesity(aHR=0.72,95%CI:0.59–0.87)had a positive impact on mortality in people older than 60 years.All-2 cause mortality decreased rapidly until reaching a BMI of 25.7 kg/m(aHR=0.95,95%CI:0.92–0.98)and increased slightly above that value,indicating a U-shaped association.The beneficial impact of being overweight on mortality was robust in most subgroups and sensitivity analyses.Conclusion This study provides additional evidence that overweight and mild obesity may be inversely related to the risk of death in individuals older than 60 years.Therefore,it is essential to consider age differences when formulating health and weight management strategies.
文摘China's perfume market has been experiencing significant growth.The “2024 China Perfume and Fragrance White Paper”,jointly published by Eternal Group,DSM-Firmenich,and Ipsos in September 2024,reveals that the market surged from 11.4 billion yuan in 2018 to 22.9 billion yuan in 2023,achieving a compound annual growth rate(CAGR) of 15%.With projections estimating a rise to 44 billion yuan by 2028 at a 14% CAGR,the sector's long-term growth prospects remain strong.
基金supported by the Higher Institution Centre of Excellence(HICoE)program(MO002-2019&TIDREC-2023)funded by the Bernhard Nocht Institute for Tropical Medicine,Hamburg,Germany[100-TNCPI/INT 16/6/2(005/2020)].
文摘Tick studies in Malaysia have experienced a dynamic evolution characterized by periods of growth,stagnation,and the potential for revival.Beginning during the colonial era in the early 1900s,tick studies were primarily conducted by European scientists and curators,establishing the foundation for tick taxonomy in the region.Pioneering works by George Henry Falknier Nuttall and Cecil Warburton introduced several new tick species,including Haemaphysalis(H.)calva,H.mjoebergi,H.vidua and H.wellingtoni[1].However,some records from this period are now considered doubtful,for instance Amblyomma(A.)breviscutatum,A.clypeolatum and A.integrum.The 1929 description of Ornithodoros batuensis by Stanley Hirst[2]marked the first documentation of a soft tick species in Malaysia,setting the stage for subsequent research endeavours.The Golden Age of tick studies(early 1950s-late 1980s)in Malaysia saw a surge in tick research activities.
文摘The Polar Regions host one of the harshest and most unique ecosystems on Earth,harboring a diverse array of micro-and macro-organisms.These inhabitants showcase remarkable taxonomic and genetic originality,presenting unparalleled opportunities for bioprospecting,alongside demonstrating extraordinary adaptation mechanisms for survival.
文摘Vietnam's manufacturing and processing companies areop timistic about business prospects in the second quarter(Q2)of this year,according to a recent survey by the National Statis-tics Office(Gso).The results of the survey indicate that 45.8%of bustnesses anticipate improved business performance in Q22025 compared to Ql while 39.2%expect stability and l5%foresee encountering more difficulties ahead.
基金supported by the Natural Science Foundation of Jiangsu Province(Grants No BK20232038).
文摘In recent years,magnesium(Mg)alloys and magnesium matrix composites(MMCs)have made significant progress in the application of advanced equipment,lightweighting and biomedical engineering.Additive manufacturing(AM),with high flexibility and design freedom,is of great significance for the rapid prototyping of high-performance Mg alloy components with complex structures.Due to the layerby-layer deposition characteristics of additive manufactured Mg alloys and MMCs,the components exhibit distinct microstructures and properties compared to those manufactured via traditional technologies.AM technology for Mg alloys and MMCs still faces challenges in practical applications,including raw materials,processing conditions,post-processing,and selection of process parameters.This paper presents an overview of recent progress in Mg alloys and MMCs fabricated using various AM technologies,including wire-arc directed energy deposition(WA-DED),laser powder bed fusion(LPBF)and solid-state additive manufacturing(SSAM).The relationships between process parameters,forming quality,microstructure and properties are systematically discussed.In particular,the influence of manufacturing processes and material composition on corrosion behavior and biocompatibility is investigated.Additionally,mechanisms and applications of field-assisted additive manufacturing and post-treatment in defect suppression,microstructure evolution,and performance improvement in Mg alloys and MMCs are summarized.Finally,the potential applications of AM Mg alloys and MMCs are prospected,and future development trends are proposed.
