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TIM-3基因多态性及慢性HBV感染患者25(OH)D、PDCD4 mRNA、miRNA水平与病情程度的关联
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作者 付涵 卢宣霖 +2 位作者 叶恩兰 罗敏 冉海敬 《中华医院感染学杂志》 北大核心 2025年第4期495-500,共6页
目的 探究慢性乙型肝炎病毒(HBV)感染患者25羟维生素D[25(OH)D]、程序性细胞死亡因子4(PDCD4)mRNA、微小核糖核酸(miRNA)水平,T细胞免疫球蛋白黏蛋白分子-3(TIM-3)基因多态性和各指标与病情程度的关联。方法 选取重庆市涪陵区中医院2022... 目的 探究慢性乙型肝炎病毒(HBV)感染患者25羟维生素D[25(OH)D]、程序性细胞死亡因子4(PDCD4)mRNA、微小核糖核酸(miRNA)水平,T细胞免疫球蛋白黏蛋白分子-3(TIM-3)基因多态性和各指标与病情程度的关联。方法 选取重庆市涪陵区中医院2022年6月-2023年12月收治的149例慢性HBV感染患者为研究组,研究组患者按照病情程度分为慢性乙肝组75例、肝硬化组43例、肝癌组31例;另选取150名健康体检者为健康组。统计研究组、健康组TIM-3基因多态性分布,比较研究组、健康组及不同病情程度组25(OH)D、PDCD4 mRNA、miR-122、miR-155水平,采用Spearman分析25 (OH)D、PDCD4 mRNA、miR-122、miR-155水平与病情程度的相关性。结果 研究组和健康组均符合Hardy-Weinb urg平衡(P=0.281、0.697);研究组TIM-3 rs10053538位点GG基因型与G等位基因频率分别为79.87%与89.60%低于健康组,而GT基因型与T等位基因频率分别为19.46%与10.40%高于健康组(P<0.05)。研究组25(OH)D、PDCD4 mRNA水平分别为(16.62±5.04)ng/ml、(1.63±0.49)低于健康组,miR-122和miR-155水平分别为(6.94±2.01)和(8.47±2.08)高于健康组(P<0.05)。肝硬化组和肝癌组25(OH)D、PDCD4 mRNA水平低于慢性乙肝组,且肝癌组低于肝硬化组,肝硬化组和肝癌组miR-122和miR-155水平高于慢性乙肝组,且肝癌组高于肝硬化组(P<0.05)。25(OH)D、PDCD4 mRNA水平与病情程度呈负相关(r=-0.627、-0.608,P均<0.05);miR-122、miR-155水平与病情严重程度呈正相关(r-0.719、0.652,P均<0.05)。结论 慢性HBV感染患者25 (OH) D、PDCD4mRNA、miR-122、miR-155表达异常,TIM-3rs10053538位点基因多态性与慢性HBV感染患者的易感染性有关。 展开更多
关键词 慢性乙型肝炎病毒感染 T细胞免疫球蛋白黏蛋白分子-3 基因多态性 25羟维生素d 程序性细胞死亡因子4 微小核糖核酸 病情程度 关联
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Islay3D—A Programming Environment for Authoring Interactive 3D Animations in Terms of State-Transition Diagram
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作者 Dandy Ling Kwong Michitoshi Niibori +2 位作者 Shusuke Okamoto Masaru Kamada Tatsuhiro Yonekura 《Journal of Software Engineering and Applications》 2014年第3期177-186,共10页
An educational programming language is a programming language that is designed primarily as a learning instrument and not so much as a tool for writing programs for production. Three-dimensional (3D) interactive anima... An educational programming language is a programming language that is designed primarily as a learning instrument and not so much as a tool for writing programs for production. Three-dimensional (3D) interactive animations provide an effective means to engage the attention of the audience to learn programming language. Traditionally, creating 3D games had been difficult as it requires specialized programming skills. However, it had been proven that the state-transition diagram, which is the most fundamental principle for automata, is intuitively so comprehensive that even children can create programs for interactive animations and video games in the two-dimensional world. Islay3D is a programming environment for authoring interactive 3D animations based on this concept. In this paper, the Islay3D animation language is introduced, where a character is modeled as an object, and its behavior is defined in term of a set of state-transition diagrams. The interpretation of the state-transition diagrams to JavaScript is also presented. Finally, the web-based programming environment is introduced. With the web-based platform, the public will be able express their creativity in creating interactive 3D animations and video games easily from within their browser. 展开更多
关键词 3d Visual programming Language Computer GAMES State TRANSITION dIAGRAM Web Service
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The parallel 3D magnetotelluric forward modeling algorithm 被引量:28
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作者 Tan Handong Tong Tuo Lin Changhong 《Applied Geophysics》 SCIE CSCD 2006年第4期197-202,共6页
The workload of the 3D magnetotelluric forward modeling algorithm is so large that the traditional serial algorithm costs an extremely large compute time. However, the 3D forward modeling algorithm can process the dat... The workload of the 3D magnetotelluric forward modeling algorithm is so large that the traditional serial algorithm costs an extremely large compute time. However, the 3D forward modeling algorithm can process the data in the frequency domain, which is very suitable for parallel computation. With the advantage of MPI and based on an analysis of the flow of the 3D magnetotelluric serial forward algorithm, we suggest the idea of parallel computation and apply it. Three theoretical models are tested and the execution efficiency is compared in different situations. The results indicate that the parallel 3D forward modeling computation is correct and the efficiency is greatly improved. This method is suitable for large size geophysical computations. 展开更多
关键词 Magnetotelluric 3d forward modeling MPI parallel programming design 3d staggered-grid finite difference method parallel algorithm.
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Implementation and verification of interface constitutive model in FLAC^(3D) 被引量:6
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作者 Hai-min WU Yi-ming SHU Jun-gao ZHU 《Water Science and Engineering》 EI CAS 2011年第3期305-316,共12页
Due to the complexity of soil-structure interaction, simple constitutive models typically used for interface elements in general computer programs cannot satisfy the requirements of discontinuous deformation analysis ... Due to the complexity of soil-structure interaction, simple constitutive models typically used for interface elements in general computer programs cannot satisfy the requirements of discontinuous deformation analysis of structures that contain different interfaces. In order to simulate the strain-softening characteristics of interfaces, a nonlinear strain-softening interface constitutive model was incorporated into fast Lagrange analysis of continua in three dimensions (FLAC3D) through a user-defined program in the FISH environment. A numerical simulation of a direct shear test for geosynthetic interfaces was conducted to verify that the interface model was implemented correctly. Results of the numerical tests show good agreement with the results obtained from theoretical calculations, indicating that the model incorporated into FLAC3D can simulate the nonlinear strain-softening behavior of interfaces involving geosynthetic materials. The results confirmed the validity and reliability of the improved interface model. The procedure and method of implementing an interface constitutive model into a commercial computer program also provide a reference for implementation of a new interface constitutive model in FLAC3D. 展开更多
关键词 interface element constitutive model FLAC3d programming in FISH environment
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甲型流感病毒感染血清SFTPD、LDH、Tim-3、PDCD5表达及意义 被引量:1
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作者 李蕾 吉浩然 +1 位作者 赵晓赟 侯敏 《中华医院感染学杂志》 CSCD 北大核心 2024年第24期3702-3706,共5页
目的探讨甲型流感病毒感染血清表面活性蛋白D(SFTPD)、乳酸脱氢酶(LDH)、免疫调节分子T细胞免疫球蛋白及黏蛋白域蛋白3(Tim-3)及程序化细胞死亡分子5(PDCD5)水平与机体炎症反应及病情程度的关系。方法选取2023年4月-2023年10月在天津市... 目的探讨甲型流感病毒感染血清表面活性蛋白D(SFTPD)、乳酸脱氢酶(LDH)、免疫调节分子T细胞免疫球蛋白及黏蛋白域蛋白3(Tim-3)及程序化细胞死亡分子5(PDCD5)水平与机体炎症反应及病情程度的关系。方法选取2023年4月-2023年10月在天津市胸科医院接受治疗的甲型流感病毒感染患者569例为研究对象,根据病情程度分为轻症甲流组429例和重症甲流组140例,同时选取575名同期健康体检者为对照组。比较三组炎症反应指标、血清SFTPD、LDH、Tim-3、PDCD5水平,采用Pearson相关性分析血清SFTPD、LDH、Tim-3、PDCD5水平与炎症反应指标、病情程度的相关性。结果重症甲流组血清淀粉样蛋白(SAA)、C-反应蛋白(CRP)、降钙素原(PCT)、白细胞介素(IL)-6、IL-17水平均高于轻症甲流组、对照组(P<0.05),相比于对照组,轻症甲流组更高(P<0.05)。重症甲流组血清SFTPD、LDH、Tim-3、PDCD5水平均高于轻症甲流组、对照组(P<0.05),相比于对照组,轻症甲流组更高(P<0.05)。血清SFTPD、LDH、Tim-3、PDCD5水平与SAA、CRP、PCT、IL-6、IL-17、病情程度均呈正相关(P<0.05)。结论血清SFTPD、LDH、Tim-3、PDCD5表达与甲型流感病毒感染的发生、发展有关,且与患者炎症反应及病情程度密切相关,临床可据此判断甲型流感病毒感染疾病病情进展。 展开更多
关键词 甲型流感病毒 表面活性蛋白d 乳酸脱氢酶 免疫调节分子T细胞免疫球蛋白及黏蛋白域蛋白3 程序化细胞死亡分子5 炎症反应
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The Comparison of Different Degree of Convexity and 3D Modeling of Involute Hyperbolic Arch Dam 被引量:3
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作者 DU Qi-lu DU Ting-na ZHAO Hai-feng 《Computer Aided Drafting,Design and Manufacturing》 2011年第2期7-12,共6页
Because of good quality of compressive resistance, the hyperbolic arch dam is being increasingly applied to engineering projects. In order to satisfy the needs of compressive resistance under the conditions of high wa... Because of good quality of compressive resistance, the hyperbolic arch dam is being increasingly applied to engineering projects. In order to satisfy the needs of compressive resistance under the conditions of high water pressure, a stress analysis is required for the dam. During the stress analysis process however, due to the complexity of the three-dimensional modeling, it is very hard to form a model. Therefore, the stress analysis process is a barrier for the arch dam. In this article, based on the research of the new line-type arch dam, a mathematical model in different degree of convexity conditions of the dam is established; using the C + + language program, a computer three-dimensional model simulation is realized on AutoCAD. The accurate three-dimensional model is providing a finite element optimization design of the involute hyperbolic arch dam for the next step. 展开更多
关键词 the involute hyperbolic arch dam arch axis upstream arch arc downstream arch arc 3d modelling C program design
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An object oriented multi-robotic graphic simulation environment for programming the welding tasks
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作者 崔泽 赵杰 +1 位作者 崔岩 蔡鹤皋 《China Welding》 EI CAS 2002年第1期77-83,共7页
An object oriented multi robotic graphic simulation environment is described in this paper. Object oriented programming is used to model the physical objects of the robotic workcell in the form of software objects ... An object oriented multi robotic graphic simulation environment is described in this paper. Object oriented programming is used to model the physical objects of the robotic workcell in the form of software objects or classes. The virtual objects are defined to provide the user with a user friendly interface including realistic graphic simulation and clarify the software architecture. The programming method of associating the task object with active object effectively increases the software reusability, maintainability and modifiability. Task level programming is also demonstrated through a multi robot welding task that allows the user to concentrate on the most important aspects of the tasks. The multi thread programming technique is used to simulate the interaction of multiple tasks. Finally, a virtual test is carried out in the graphic simulation environment to observe design and program errors and fix them before downloading the software to the real workcell. 展开更多
关键词 object oriented programming task level programming welding task 3d graphic simulation expert system
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Power Consumption Optimization for 3D Graphics Rendering
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作者 Lidong Xing Tao Li +1 位作者 Hucai Huang Jungang Han 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2019年第1期42-50,共9页
This paper studies some programming techniques for low power rendering for 3 D graphics. These techniques are derived from analysis and simulation results of hardware circuits of GPU. Although low power3 D graphics ha... This paper studies some programming techniques for low power rendering for 3 D graphics. These techniques are derived from analysis and simulation results of hardware circuits of GPU. Although low power3 D graphics hardware design has been studied by other researchers,low power programming techniques from hardware perspective have not been investigated in depth. There are many factors that affect 3 D graphics rendering performance,such as the number of vertices,vertex sharing,level of details,texture mapping,and rendering algorithms. An analytical study of graphics rendering workload is performed and the effect of a number of programming tips such as vertex sharing,clock gating and buffering of unmoving or translational objects is deeply studied. The results presented in this paper can be used to guide 3 D graphics programming for optimizing both power consumption and performance. 展开更多
关键词 GPU 3d GRAPHICS RENdERING low power WORKLOAd VERTEX SHARING GRAPHICS programMING
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A NEW METHOD FOR SOLUTION OF 3D ELASTIC-PLASTIC FRICTIONAL CONTACT PROBLEMS
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作者 张洪武 钟万勰 顾元宪 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2001年第7期756-765,共10页
The solution of 3 D elastic-plastic frictional contact problems belongs to the un specified boundary problems where the interaction between two kinds of nonlinearities should occur. Considering the difficulties for th... The solution of 3 D elastic-plastic frictional contact problems belongs to the un specified boundary problems where the interaction between two kinds of nonlinearities should occur. Considering the difficulties for the solution of 3 D frictional contact problems, the key part is the determination of the tangential slip states at the contact points, and a great amount of computing work is needed for a high accuracy result. A new method based on a combination of programming and iteration methods, which are respectively known as two main kinds of methods for contact analysis, was put forward to deal with 3 D elastic-plastic contact problems. Numerical results demonstrate the efficiency of the algorithm illustrated here. 展开更多
关键词 3d frictional contact ELASTO-PLASTICITY programming method iteration method the finite element method
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铝型材挤压模具的CAD技术 被引量:1
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作者 叶南海 刘子建 《机械科学与技术》 CSCD 北大核心 2004年第5期621-624,共4页
UG是一个功能强大的CAD/CAE/CAM软件 ,其三维结构建模功能尤为突出 ;而DELPHI则为面向对象的可视化编程语言 ,界面友好。基于此 ,根据挤压模具的强度设计理论 ,建立约束目标函数 ,对模具的几何结构参数进行优化及其强度计算分析工作 ,... UG是一个功能强大的CAD/CAE/CAM软件 ,其三维结构建模功能尤为突出 ;而DELPHI则为面向对象的可视化编程语言 ,界面友好。基于此 ,根据挤压模具的强度设计理论 ,建立约束目标函数 ,对模具的几何结构参数进行优化及其强度计算分析工作 ,最后根据UG的二次开发语言GRIP ,对挤压模具进行参数化设计 ,实行三维结构实体建模。此举可为挤压模具后续的CAE、CAM打下坚实的基础 。 展开更多
关键词 模具结构优化 参数化设计 GRIP编程 三维结构建模
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采油平台三维建模CAD系统的开发与应用
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作者 初新杰 《装备制造技术》 2011年第5期73-76,82,共5页
主要讨论了采油平台三维建模CAD系统的开发,即针对国内采油平台设计的现状,按照结构化生命周期法的原理,开发了一套适合采油平台设计使用的软件,并将研究成果成功应用于海上平台的三维图设计,显著提高了海上平台设计水平,提高了设计品质... 主要讨论了采油平台三维建模CAD系统的开发,即针对国内采油平台设计的现状,按照结构化生命周期法的原理,开发了一套适合采油平台设计使用的软件,并将研究成果成功应用于海上平台的三维图设计,显著提高了海上平台设计水平,提高了设计品质;在开发方法、设计分析方法、参数化建模、信息化管理、版本管理等方面的技术研究,也能适用于其他工程领域的设计,具有一定的推广实用价值。 展开更多
关键词 采油平台 三维建模 工程数据库 程序设计 应用
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STAAD软件二次开发在栈桥整体计算中的应用 被引量:4
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作者 叶葱葱 《福建建筑》 2016年第2期106-108,共3页
STAAD软件,虽然至今尚未提供符合中国规范的配筋模块,但可以利用其公开的函数库进行二次开发。研究证明,二次开发的STAAD软件可以克服其他设计计算软件缺陷,提高设计工作人员工作效率和设计质量。文章提供了二次开发的STADD软件主要设... STAAD软件,虽然至今尚未提供符合中国规范的配筋模块,但可以利用其公开的函数库进行二次开发。研究证明,二次开发的STAAD软件可以克服其他设计计算软件缺陷,提高设计工作人员工作效率和设计质量。文章提供了二次开发的STADD软件主要设计思路。 展开更多
关键词 输煤栈桥 三维建模 STAAd 二次开发
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An Intelligent Design of Electron Lens System
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作者 Let Wei Tong Linsu & Wu Shengli (Electronic Engineering Department of Southeast University, Naming 210096, P. R. China) (Shenyang Aircraft Manufacture Company) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1996年第1期75-86,共12页
At present, the main work of electron optical system CAD is solving equations and calculating mumerical values. However, the design perhaps needs more inference and expertise than numerical calculations because the st... At present, the main work of electron optical system CAD is solving equations and calculating mumerical values. However, the design perhaps needs more inference and expertise than numerical calculations because the structure of electron lens system is complicated. In this paper, a primary expert system is applied to design the electron lens system intelligently. This expert system is combined with SEU-3D program which is used to simulate the electron optical system to optimize the electron lens systems. In spite of this, the expert system which is established in this paper can also be used to diagnose the electron lens system. Although the knowledge base is small and rules are not abundant, this paper has used this system to obtain some very useful results. The initial success with this system suggests that further work need to be done whether more rules and knowledge will be added to extend the ability of expert system. 展开更多
关键词 Intelligent design of electron lens system Expert system Knowledge base. SEU-3d program
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Customized Development of CAXASolid
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作者 YU Si-jia YAN Guang-rong LEI Yi 《Computer Aided Drafting,Design and Manufacturing》 2006年第2期30-37,共8页
CAXASolid, a 3D CAD innovation platform with open structure, provides users with kinds of customized development strategies at different levels. The whole theoretical framework of CAXASolid is introduced. Users can cu... CAXASolid, a 3D CAD innovation platform with open structure, provides users with kinds of customized development strategies at different levels. The whole theoretical framework of CAXASolid is introduced. Users can customize their system through application integration, data integration, integration by DLL or integration by COM. Focusing on the customization techniques with COM components, the development method and process are illustrated with some case studies. 展开更多
关键词 3d CAd CAXASolid customized development IronCAd Application programming Interface (ICAPI)
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基于地球物理目标参数的三维观测系统优化设计 被引量:45
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作者 尹成 吕公河 +2 位作者 田继东 徐锦玺 尚应军 《石油物探》 EI CSCD 2006年第1期74-78,共5页
对于陆上三维地震采集的线束状观测系统优化设计,记录仪器的有效利用道数、观测系统总的覆盖次数、排列片的最大炮检距是最为重要的地球物理目标参数。针对这3个目标参数所论证的期望值的偏差最小化,提出了一套三维观测系统优化设计方法... 对于陆上三维地震采集的线束状观测系统优化设计,记录仪器的有效利用道数、观测系统总的覆盖次数、排列片的最大炮检距是最为重要的地球物理目标参数。针对这3个目标参数所论证的期望值的偏差最小化,提出了一套三维观测系统优化设计方法,即利用有约束的数学规划求解优化的目标函数,实现三维观测系统参数的最优化设计。应用该设计方法对胜利探区4个实际区块的观测系统参数进行了优化设计和对比分析,结果表明,在窄方位角采集、纵横向覆盖次数均匀分布等方面该方法的效果较好。 展开更多
关键词 三维地震 地震采集设计 观测系统 优化设计 数学规划
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中药注射剂三维荧光等高线图识别程序的设计与检验 被引量:10
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作者 徐永群 李兴旺 +1 位作者 黄冬兰 陈小康 《分析测试学报》 CAS CSCD 北大核心 2007年第4期484-487,共4页
用统计模式识别法设计了中药注射剂三维荧光指纹图谱的识别程序,对刺五加、红花、血栓通和香丹4种注射剂进行了识别,识别结果正确。研究表明:该程序分辨率高,便于自动化,可用于中药注射剂的真伪鉴别和质量监控。
关键词 中药注射剂 三维荧光等高线 程序设计 图像识别
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基于UG的模具三维设计与制造 被引量:15
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作者 蒋萌 葛正浩 +1 位作者 王文君 元庆凯 《塑料》 CAS CSCD 北大核心 2010年第2期20-22,共3页
随着现代生活节奏的加快,模具产业要求在更短的时间内实现产品设计与制造的高效、高质量,这就需要利用功能强大的设计与制造辅助软件开发产品。应用UG软件进行产品及其模具的三维设计,并利用UG强大的CAM技术对模具零件(型腔/型芯)进行加... 随着现代生活节奏的加快,模具产业要求在更短的时间内实现产品设计与制造的高效、高质量,这就需要利用功能强大的设计与制造辅助软件开发产品。应用UG软件进行产品及其模具的三维设计,并利用UG强大的CAM技术对模具零件(型腔/型芯)进行加工,生成加工程序,对于生产有现实指导意义。 展开更多
关键词 手机前盖 UG 三维模具设计 NC加工 程序
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基于PMAC的三维激光加工自动编程系统的研究 被引量:8
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作者 苏敏 石世宏 胡进 《激光与红外》 CAS CSCD 北大核心 2006年第6期433-435,共3页
针对三维激光加工的特点和具体要求,介绍了作者在开放式数控系统PMAC平台上,利用通用CAD/CAM软件Unigraphics(UG)的CAM模块,从CAD模型中提取5轴联动数控加工的刀轨数据,并经后置处理转化为激光三维加工的机床数据,然后在MATLAB中进行仿... 针对三维激光加工的特点和具体要求,介绍了作者在开放式数控系统PMAC平台上,利用通用CAD/CAM软件Unigraphics(UG)的CAM模块,从CAD模型中提取5轴联动数控加工的刀轨数据,并经后置处理转化为激光三维加工的机床数据,然后在MATLAB中进行仿真,最后生成PMAC数控代码进行加工。开发出的三维激光加工软件实用性强,可快速、高效地完成对三维复杂形状工件的激光加工。 展开更多
关键词 激光三维加工 开放式数控系统 自动编程
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发动机连杆精细有限元分析模型和算法的研究 被引量:21
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作者 戚刚 吴昌华 张南林 《中国机械工程》 EI CAS CSCD 北大核心 2001年第3期282-284,共3页
在总结大量连杆计算经验的基础上 ,分析了影响计算精度的各种因素 ,提出了一个精细有限元组合计算模型 :摒弃了各种近似处理方法 ,计算模型完全根据连杆实际结构确定 ,计入了连杆组装的全部零件以及活塞销、活塞和曲轴 ,其间所有配合关... 在总结大量连杆计算经验的基础上 ,分析了影响计算精度的各种因素 ,提出了一个精细有限元组合计算模型 :摒弃了各种近似处理方法 ,计算模型完全根据连杆实际结构确定 ,计入了连杆组装的全部零件以及活塞销、活塞和曲轴 ,其间所有配合关系用有摩擦的 3维弹性多体接触模型模拟。采用有限元参数二次规划算法 ,并结合多重多支的子结构技术求解。 展开更多
关键词 连杆 有限元 弹性多体接触 多重子结构 参数二次规划法 舰用高速柴油机
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三维姿态实时显示的小型无人机飞控仿真系统 被引量:8
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作者 张云洲 胡禹超 +1 位作者 吴成东 宋云宏 《实验室研究与探索》 CAS 北大核心 2015年第1期73-78,83,共7页
本文设计并实现了一种小型无人机飞行控制仿真系统,规划了合理的系统架构,由在环程序、飞行动力学模型、地面站程序及三维可视化显示等部分共同构成仿真系统。针对实际问题,提出了飞行姿态的三维直观显示、动力学仿真模拟的方法,结合硬... 本文设计并实现了一种小型无人机飞行控制仿真系统,规划了合理的系统架构,由在环程序、飞行动力学模型、地面站程序及三维可视化显示等部分共同构成仿真系统。针对实际问题,提出了飞行姿态的三维直观显示、动力学仿真模拟的方法,结合硬件在环和软件在环等两种方式建立了数据链路,构建了三维飞行器模型并导入仿真系统。仿真与实际飞行数据表明,所构建的仿真系统能够很好地满足小型无人机姿态控制和飞行仿真,实现了较高的精度和良好的实时性。 展开更多
关键词 无人机 飞行控制 仿真系统 三维姿态 数据链路 在环程序
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